                               SEQUENCE LISTING

<110> AMGEN INC. 
 
<120> VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE 
      (TIMP-3), COMPOSITIONS AND METHODS

<130> A-1827-WO-PCT

<140>
<141>

<150> 61/940,673
<151> 2014-02-17

<150> 61/802,988
<151> 2013-03-18

<150> 61/798,160
<151> 2013-03-15

<150> 61/782,613
<151> 2013-03-14

<160> 99    

<170> PatentIn version 3.5

<210> 1
<211> 633
<212> DNA
<213> Homo sapiens

<400> 1
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccaca cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccc                                   633


<210> 2
<211> 211
<212> PRT
<213> Homo sapiens

<400> 2
Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 
1               5                   10                  15      


Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 3
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Lys, Glu, Asn or Ser

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Val or Thr

<220>
<221> MOD_RES
<222> (49)..(49) 
<223> Lys, Glu, Asn or Ser

<220>
<221> MOD_RES
<222> (50)..(50) 
<223> Lys or Asn

<220>
<221> MOD_RES
<222> (51)..(51) 
<223> Leu, Asn or Thr

<220>
<221> MOD_RES
<222> (52)..(52) 
<223> Val or Thr

<220>
<221> MOD_RES
<222> (53)..(53) 
<223> Lys or Thr

<220>
<221> MOD_RES
<222> (56)..(56) 
<223> Pro or Asn

<220>
<221> MOD_RES
<222> (57)..(57) 
<223> Phe or Asn

<220>
<221> MOD_RES
<222> (58)..(58) 
<223> Gly or Thr

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Thr, Glu or Asn

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Lys, Thr or Asn

<220>
<221> MOD_RES
<222> (67)..(67) 
<223> Met or Thr

<220>
<221> MOD_RES
<222> (68)..(68) 
<223> Lys or Ser

<220>
<221> MOD_RES
<222> (74)..(74) 
<223> Thr or Glu

<220>
<221> MOD_RES
<222> (75)..(75) 
<223> Lys or Asn

<220>
<221> MOD_RES
<222> (77)..(77) 
<223> Pro or Thr

<220>
<221> MOD_RES
<222> (78)..(78) 
<223> His, Asp, Glu or Asn

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Gln, Glu or Thr

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Lys or Asn

<220>
<221> MOD_RES
<222> (96)..(96) 
<223> Glu, Thr or Asn

<220>
<221> MOD_RES
<222> (97)..(97) 
<223> Val or Asn

<220>
<221> MOD_RES
<222> (98)..(98) 
<223> Asn or Thr

<220>
<221> MOD_RES
<222> (99)..(99) 
<223> Lys or Thr

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Asp or Asn 

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Lys or Thr

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Lys or Ser

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Arg, Asn or Thr

<220>
<221> MOD_RES
<222> (140)..(140)
<223> His or Thr

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Thr or Asn 

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Lys or Thr

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Thr or Asn

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Met or Thr

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Gly or Thr

<220>
<221> MOD_RES
<222> (181)..(181)
<223> His or Asn

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Ala or Thr

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Arg or Asn

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Lys or Thr

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Pro or Asn

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Lys or Thr

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Ala, Val or Tyr

<400> 3
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Xaa Val Xaa Gly 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Glu Gly Xaa Xaa Xaa Thr Leu Val Tyr Xaa Ile 
    50                  55                  60                  


Xaa Gln Xaa Xaa Met Tyr Arg Gly Phe Xaa Xaa Met Xaa Xaa Val Xaa 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Xaa Leu Xaa 
                85                  90                  95      


Xaa Xaa Xaa Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Xaa Gly Xaa 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Xaa Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Xaa Gly Leu Asn Tyr Xaa Tyr Xaa Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Xaa Ser Xaa 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Xaa Asp Xaa Leu Ser Asn Phe Xaa Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys Xaa Tyr Xaa Cys Ile Xaa Gln Xaa Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Xaa Asp Xaa Ser Ile Ile Asn Xaa 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 4
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Thr, His, Lys, Pro, Arg, Ser or Trp

<220>
<221> MOD_RES
<222> (27)..(27) 
<223> Ser or Ala

<220>
<221> MOD_RES
<222> (28)..(28) 
<223> Pro, Asp, Leu or Ser

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Gln or Asn

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Asp or Thr

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Arg, Thr, Phe, Ala or Asn

<220>
<221> MOD_RES
<222> (45)..(45) 
<223> Lys, Ile or Thr

<220>
<221> MOD_RES
<222> (46)..(46) 
<223> Val or Asp

<220>
<221> MOD_RES
<222> (48)..(48) 
<223> Gly or Ser

<220>
<221> MOD_RES
<222> (49)..(49) 
<223> Lys or Ser

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Leu or Thr

<220>
<221> MOD_RES
<222> (53)..(53) 
<223> Lys or Thr

<220>
<221> MOD_RES
<222> (54)..(54) 
<223> Glu or Tyr

<220>
<221> MOD_RES
<222> (67)..(67) 
<223> Met or Asn

<220>
<221> MOD_RES
<222> (68)..(68) 
<223> Lys or Ile

<220>
<221> MOD_RES
<222> (78)..(78)
<223> His, Asp or Trp

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Asp or Asn

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Asn or Ser

<400> 4
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Cys Xaa Xaa Ser His Pro Xaa 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Xaa Ile Val Ile Xaa Ala Xaa Xaa Val Xaa 
        35                  40                  45              


Xaa Lys Xaa Val Xaa Xaa Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Xaa Xaa Met Tyr Arg Gly Phe Thr Lys Met Pro Xaa Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Xaa Lys Ser Ile Ile Xaa Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 5
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 5
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 
        35                  40                  45              


Ser Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 6
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 6
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 
        35                  40                  45              


Glu Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 7
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 7
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 8
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 8
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Glu 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 9
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 9
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro Glu Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 10
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 10
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro Glu Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 11
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 11
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro Glu Val Glu 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 12
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 12
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro Glu Val Glu 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 13
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 13
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Glu Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 14
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 14
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 15
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 16
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 16
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Glu Val Glu 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 17
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 17
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Glu 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 18
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 18
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Asn Val Thr Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Glu Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 19
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 19
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Asn Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Glu Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 20
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 20
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 
        35                  40                  45              


Asn Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 21
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 21
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Asn Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Glu Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 22
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 22
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Ser Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 23
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 23
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Ser Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 24
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 24
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Ser Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Ser Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 25
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 25
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Glu 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 26
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 26
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Asn Val Thr Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 27
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 27
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Asn Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 28
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 28
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Ser Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 29
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 29
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Ser Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Ser Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 30
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 30
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Asn Leu Thr Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 31
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 31
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Asn Phe Thr Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 32
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 32
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Asn Phe Thr Thr Leu Val Tyr Asn Ile 
    50                  55                  60                  


Thr Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 33
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 33
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 34
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 34
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Ser Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 35
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 35
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Ser Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 36
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 36
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Asn Ile 
    50                  55                  60                  


Thr Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 37
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 37
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Asn Gln Thr Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 38
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 38
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Asn Met Thr His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 39
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 39
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro Asn Val Thr 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 40
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 40
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Asn Leu Thr 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 41
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 41
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Asn 
                85                  90                  95      


Val Thr Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 42
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 42
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Asn Asn Thr Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 43
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 43
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asn Gly Thr 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 44
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 44
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Asn Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 45
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 45
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Thr Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 46
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 46
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Asn Tyr Thr Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 47
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 47
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Asn Ser Thr 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 48
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 48
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Asn Asp Thr Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 49
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 49
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Thr Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 50
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 50
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys Asn Tyr Thr Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 51
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 51
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Asn Gln Thr Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 52
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 52
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Asn Asp Thr Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 53
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 53
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 54
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 54
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Asn Val Thr Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 55
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 55
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Tyr 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 56
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Met or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Thr or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Pro or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Ile or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Val or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (10)..(11) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Ser or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Leu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (18)..(18) 
<223> Asp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (19)..(19) 
<223> Trp or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> Gly or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (21)..(21) 
<223> Ala or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (22)..(22) 
<223> Glu or any amino acid from a heterologous signal peptide

<220>
<221> MOD_RES
<222> (23)..(23) 
<223> Ala or any amino acid from a heterologous signal peptide

<400> 56
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Val 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 57
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S, F57N, I205F, A208G)

<400> 57
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Phe Ile Asn Gly Thr Asp Pro 
            180                 185             


<210> 58
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S, F57N, A208G)

<400> 58
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Gly Thr Asp Pro 
            180                 185             


<210> 59
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S, F57N, I205Y)

<400> 59
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Tyr Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 60
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S, F57N, I205Y, A208G)

<400> 60
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Tyr Ile Asn Gly Thr Asp Pro 
            180                 185             


<210> 61
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T,F57N,K75N,P77T,K94N,E96T,R138T,G173T)

<400> 61
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Asn Met Thr His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 62
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T,F57N,K94N,E96T,R138T,G173T)

<400> 62
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 63
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T,K50N,V52T,F57N,V97N,K99T)

<400> 63
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 64
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S,K50N,V52T,F57N,V97N,K99T,R186N,K188T)

<400> 64
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 65
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S,F57N,K94N,E96T,D110N,K112T,R138T,G173T)

<400> 65
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 66
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S,F57N,T63N,K65T,K94N,E96T,G173T)

<400> 66
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Asn Ile Thr Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 67
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T,K50N,V52T,F57N,V97N,K99T,R138T,R186N,K188T)

<400> 67
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 68
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S,F57N,T63N,K65T,K94N,E96T,Q126N,R138T)

<400> 68
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Asn Ile Thr Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Asn Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 69
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T,K50N,V52T,F57N,V97N,K99T,R186N,K188T)

<400> 69
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 70
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T,K50N,V52T,V97N,K99T,R138T,R186N,K188T)

<400> 70
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 71
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S,F57N,H78N,Q80T,K94N,E96T,R138T,G173T)

<400> 71
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 72
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S,F57N,K75N,P77T,K94N,E96T,R138T,G173T)

<400> 72
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Asn Met Thr His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 73
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T,K50N,V52T,V97N,K99T,G173T,R186N,K188T)

<400> 73
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 74
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45E,F57N,Q126N,R138T,G173T)

<400> 74
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Asn Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 75
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S,F57N,T63N,K65T,K94N,E96T,R138T,G173T)

<400> 75
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Asn Ile Thr Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 76
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S,K50N,V52T,F57N,V97N,K99T,R138T,R186N,K188T)

<400> 76
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 77
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45S.K50N,V52T,F57N,V97N,K99T,G173T,R186N,K188T)

<400> 77
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 78
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T, F57N, K94N,E96T, G173T, R186N,K188T)

<400> 78
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 79
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T, F57N, K94N,E96T, D110N,K112T, R186N,K188T)

<400> 79
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 80
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T, F57N, V97N,K99T, R138T, G173T)

<400> 80
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 81
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T, F57N, K99E G173T, R186N,K188T)

<400> 81
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Glu Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 82
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45E, K49E, F57N, K94N,E96T, D110N,K112T, G173T, R186N,K188T)

<400> 82
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Glu Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 83
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K50N,V52T, K94N,E96T, R138T, G173T)

<400> 83
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 84
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45E, K50N,V52T, K94N,E96T, D110N,K112T, R138T, G173T)

<400> 84
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 85
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K50N,V52T, K94N,E96T, R138T, G173T, R186N,K188T)

<400> 85
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 86
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45E, F57N ,T63N,K65T, K94N,E96T ,G173T, R186N,K188T)

<400> 86
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Asn Ile Thr Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 87
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> huTIMP3(K45N,V47T, F57N, K94N,E96T, D110N,K112T, G173T, R186Q,K188Q)

<400> 87
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Gln Gln Gln Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 88
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45S, F57N, K94N, E96T, R138T, G173T)

<400> 88
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 89
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45E, F57N, K94N, E96T, R138T, G173T)

<400> 89
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 90
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45E, F57N, K94N, E96T, D110N, K112T, R138T, G173T)

<400> 90
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 91
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45E, F57N, K94N, E96T, R138T, G173T, R186Q, K188Q)

<400> 91
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Gln Gln Gln Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 92
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45E, F57N, K94N, E96T, R138T, G173T, R186E)

<400> 92
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Glu Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 93
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45E, F57N, K94N, E96T, R138T, G173T, K188E)

<400> 93
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Glu Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 94
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45E, F57N, K94N, E96T, R138T, G173T, R186N, K188T)

<400> 94
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 95
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45E, K50N, V52T, K94N, E96T, D110N, K112T, R138T, G173T)

<400> 95
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 96
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45E, K50N, V52T, K94N, E96T, R138T, G173T, K188E)

<400> 96
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Glu Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 97
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K50N, V52T, F57N, K94N, E96T, R138T, G173T)

<400> 97
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 98
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K50N, V52T, F57N, K94N, E96T, D110N, K112T, R138T)

<400> 98
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             


<210> 99
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<223> HuTIMP3(K45E, F57N, K94N, E96T, D110N, K112T, R138T)

<400> 99
Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 
1               5                   10                  15      


Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 
            20                  25                  30          


Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 
        35                  40                  45              


Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 
    50                  55                  60                  


Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 
65                  70                  75                  80  


Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 
                85                  90                  95      


Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 
            100                 105                 110         


Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 
        115                 120                 125             


Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 
    130                 135                 140                 


Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 
145                 150                 155                 160 


Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 
                165                 170                 175     


Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 
            180                 185             



