                         SEQUENCE LISTING

<110>  Amgen Inc.
 
<120>  METHODS AND COMPOSITIONS RELATING TO ANTI-CCR7 ANTIGEN BINDING PROTEINS

<130>  A-1814-WO-PCT

<140>  
<141>  2014-03-13

<150>  US 61/962,296
<151>  2013-03-15

<160>  213   

<170>  PatentIn version 3.5

<210>  1
<211>  702
<212>  DNA
<213>  Human

<400>  1
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgttcct atgagctgac tcagccaccc tcagtgtccg tgtccccagg acagagagcc      120

agaatcacct gctctggaga taaattgggg gataaatatg cttcctggta tcagcagaag      180

ccaggccagt cccctctact ggtcatctat caagatagca agcggccctc agggatccct      240

gagcgattct ctggctccaa ctctggaaac acagccactc tgaccatcag cgggacccag      300

gctatggatg aggctgacta ttactgtcag gcgtggggca gcagcactgt gatattcggc      360

ggagggacca aactgaccgt cctaggtcag cccaaggcca accccactgt cactctgttc      420

ccgccctcct ctgaggagct ccaagccaac aaggccacac tagtgtgtct gatcagtgac      480

ttctacccgg gagctgtgac agtggcctgg aaggcagatg gcagccccgt caaggcggga      540

gtggagacca ccaaaccctc caaacagagc aacaacaagt acgcggccag cagctacctg      600

agcctgacgc ccgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  2
<211>  234
<212>  PRT
<213>  Human

<400>  2

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Arg Ala Arg Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Leu Gly Asp Lys Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Leu Leu Val Ile Tyr Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Gly Ser Ser Thr Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  3
<211>  33
<212>  DNA
<213>  Human

<400>  3
tctggagata aattggggga taaatatgct tcc                                    33


<210>  4
<211>  11
<212>  PRT
<213>  Human

<400>  4

Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Ser 
1               5                   10      


<210>  5
<211>  21
<212>  DNA
<213>  Human

<400>  5
caagatagca agcggccctc a                                                 21


<210>  6
<211>  7
<212>  PRT
<213>  Human

<400>  6

Gln Asp Ser Lys Arg Pro Ser 
1               5           


<210>  7
<211>  27
<212>  DNA
<213>  Human

<400>  7
caggcgtggg gcagcagcac tgtgata                                           27


<210>  8
<211>  9
<212>  PRT
<213>  Human

<400>  8

Gln Ala Trp Gly Ser Ser Thr Val Ile 
1               5                   


<210>  9
<211>  699
<212>  DNA
<213>  Human

<400>  9
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgttatg agctgactca gccaccctca gtgtccgtgt ccccaggaca gagagccaga      120

atcacctgct ctggagataa attgggggat aaatatgctt cctggtatca gcagaagcca      180

ggccagtccc ctctactggt catctatcaa gatagcaagc ggccctcagg gatccctgag      240

cgattctctg gctccaactc tggaaacaca gccactctga ccatcagcgg gacccaggct      300

atggatgagg ctgactatta ctgtcaggcg tggggcagca gcactgtgat attcggcgga      360

gggaccaaac tgaccgtcct aggtcagccc aaggccaacc ccactgtcac tctgttcccg      420

ccctcctctg aggagctcca agccaacaag gccacactag tgtgtctgat cagtgacttc      480

tacccgggag ctgtgacagt ggcctggaag gcagatggca gccccgtcaa ggcgggagtg      540

gagaccacca aaccctccaa acagagcaac aacaagtacg cggccagcag ctacctgagc      600

ctgacgcccg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      660

agcaccgtgg agaagacagt ggcccctaca gaatgttca                             699


<210>  10
<211>  233
<212>  PRT
<213>  Human

<400>  10

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Val Ser Pro Gly Gln Arg Ala Arg Ile Thr Cys Ser Gly Asp Lys Leu 
        35                  40                  45              


Gly Asp Lys Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Leu Leu Val Ile Tyr Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
                85                  90                  95      


Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Gly 
            100                 105                 110         


Ser Ser Thr Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
        115                 120                 125             


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
145                 150                 155                 160 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
                165                 170                 175     


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
            180                 185                 190         


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
        195                 200                 205             


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
    210                 215                 220                 


Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230             


<210>  11
<211>  33
<212>  DNA
<213>  Human

<400>  11
tctggagata aattggggga taaatatgct tcc                                    33


<210>  12
<211>  11
<212>  PRT
<213>  Human

<400>  12

Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Ser 
1               5                   10      


<210>  13
<211>  21
<212>  DNA
<213>  Human

<400>  13
caagatagca agcggccctc a                                                 21


<210>  14
<211>  7
<212>  PRT
<213>  Human

<400>  14

Gln Asp Ser Lys Arg Pro Ser 
1               5           


<210>  15
<211>  27
<212>  DNA
<213>  Human

<400>  15
caggcgtggg gcagcagcac tgtgata                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Human

<400>  16

Gln Ala Trp Gly Ser Ser Thr Val Ile 
1               5                   


<210>  17
<211>  702
<212>  DNA
<213>  Human

<400>  17
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgttcct atgagctgac tcagccaccc tcagtgtccg tgtccccagg acagagagcc      120

agcatcacct gctctggaga taaattgggg gataaatatg cttcctggta tcagcagaag      180

ccaggccagt cccctctact ggtcatctat caagatggca agcggccctc agggatccct      240

gagcgattct ctggctccaa ctctggaaac acagccactc tgaccatcag cgggacccag      300

gctatggatg aggctgacta ttactgtcag gcgtggggca gcagcactgt gatattcggc      360

ggagggacca aactgaccgt cctaggtcag cccaaggcca accccactgt cactctgttc      420

ccgccctcct ctgaggagct ccaagccaac aaggccacac tagtgtgtct gatcagtgac      480

ttctacccgg gagctgtgac agtggcctgg aaggcagatg gcagccccgt caaggcggga      540

gtggagacca ccaaaccctc caaacagagc aacaacaagt acgcggccag cagctacctg      600

agcctgacgc ccgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         702


<210>  18
<211>  234
<212>  PRT
<213>  Human

<400>  18

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Arg Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Leu Gly Asp Lys Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Leu Leu Val Ile Tyr Gln Asp Gly Lys Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Gly Ser Ser Thr Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  19
<211>  33
<212>  DNA
<213>  Human

<400>  19
tctggagata aattggggga taaatatgct tcc                                    33


<210>  20
<211>  11
<212>  PRT
<213>  Human

<400>  20

Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Ser 
1               5                   10      


<210>  21
<211>  21
<212>  DNA
<213>  Human

<400>  21
caagatggca agcggccctc a                                                 21


<210>  22
<211>  7
<212>  PRT
<213>  Human

<400>  22

Gln Asp Gly Lys Arg Pro Ser 
1               5           


<210>  23
<211>  27
<212>  DNA
<213>  Human

<400>  23
caggcgtggg gcagcagcac tgtgata                                           27


<210>  24
<211>  9
<212>  PRT
<213>  Human

<400>  24

Gln Ala Trp Gly Ser Ser Thr Val Ile 
1               5                   


<210>  25
<211>  699
<212>  DNA
<213>  Human

<400>  25
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgttcct atgagctgac tcagccaccc tcagtgtccg tgtccccagg acagacagcc      120

agcatcacct gctctggaaa taaattgggg gataaatatg cttcctggta tcatcagaag      180

ccaggccagt cccctgtgct ggtcatctat caagataaca agcggccctc agggatccct      240

gagcgattct ctggctccaa ctctgggaac acagccactc tgaccatcag cgggacccag      300

actatggatg aggctgacta tttctgtcag gcgtgggaca ggactgtggt attcggcgga      360

gggaccaaac tgaccgtcct aggtcagccc aaggccaacc ccactgtcac tctgttcccg      420

ccctcctctg aggagctcca agccaacaag gccacactag tgtgtctgat cagtgacttc      480

tacccgggag ctgtgacagt ggcctggaag gcagatggca gccccgtcaa ggcgggagtg      540

gagaccacca aaccctccaa acagagcaac aacaagtacg cggccagcag ctacctgagc      600

ctgacgcccg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      660

agcaccgtgg agaagacagt ggcccctaca gaatgttca                             699


<210>  26
<211>  233
<212>  PRT
<213>  Human

<400>  26

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asn Lys 
        35                  40                  45              


Leu Gly Asp Lys Tyr Ala Ser Trp Tyr His Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Thr Met Asp Glu Ala Asp Tyr Phe Cys Gln Ala Trp 
            100                 105                 110         


Asp Arg Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
        115                 120                 125             


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
145                 150                 155                 160 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
                165                 170                 175     


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
            180                 185                 190         


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
        195                 200                 205             


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
    210                 215                 220                 


Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230             


<210>  27
<211>  33
<212>  DNA
<213>  Human

<400>  27
tctggaaata aattggggga taaatatgct tcc                                    33


<210>  28
<211>  11
<212>  PRT
<213>  Human

<400>  28

Ser Gly Asn Lys Leu Gly Asp Lys Tyr Ala Ser 
1               5                   10      


<210>  29
<211>  21
<212>  DNA
<213>  Human

<400>  29
caagataaca agcggccctc a                                                 21


<210>  30
<211>  7
<212>  PRT
<213>  Human

<400>  30

Gln Asp Asn Lys Arg Pro Ser 
1               5           


<210>  31
<211>  24
<212>  DNA
<213>  Human

<400>  31
caggcgtggg acaggactgt ggta                                              24


<210>  32
<211>  8
<212>  PRT
<213>  Human

<400>  32

Gln Ala Trp Asp Arg Thr Val Val 
1               5               


<210>  33
<211>  699
<212>  DNA
<213>  Human

<400>  33
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgttcct atgagctgac tcagccaccc tcagtgtccg tgtccccagg acagacagcc      120

agcatcacct gctctggaaa taaattgggg gataaatatg cttcctggta tcagcagaag      180

ccaggccagt cccctgtgct ggtcatctat caagataaca agcggccctc agggatccct      240

gagcgattct ctggctccaa ctctgggaac acagccactc tgaccatcag cgggacccag      300

actatggatg aggctgacta tttctgtcag gcgtgggaca ggactgtggt attcggcgga      360

gggaccaaac tgaccgtcct aggtcagccc aaggccaacc ccactgtcac tctgttcccg      420

ccctcctctg aggagctcca agccaacaag gccacactag tgtgtctgat cagtgacttc      480

tacccgggag ctgtgacagt ggcctggaag gcagatggca gccccgtcaa ggcgggagtg      540

gagaccacca aaccctccaa acagagcaac aacaagtacg cggccagcag ctacctgagc      600

ctgacgcccg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      660

agcaccgtgg agaagacagt ggcccctaca gaatgttca                             699


<210>  34
<211>  233
<212>  PRT
<213>  Human

<400>  34

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asn Lys 
        35                  40                  45              


Leu Gly Asp Lys Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Thr Met Asp Glu Ala Asp Tyr Phe Cys Gln Ala Trp 
            100                 105                 110         


Asp Arg Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
        115                 120                 125             


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
145                 150                 155                 160 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
                165                 170                 175     


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
            180                 185                 190         


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
        195                 200                 205             


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
    210                 215                 220                 


Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230             


<210>  35
<211>  33
<212>  DNA
<213>  Human

<400>  35
tctggaaata aattggggga taaatatgct tcc                                    33


<210>  36
<211>  11
<212>  PRT
<213>  Human

<400>  36

Ser Gly Asn Lys Leu Gly Asp Lys Tyr Ala Ser 
1               5                   10      


<210>  37
<211>  21
<212>  DNA
<213>  Human

<400>  37
caagataaca agcggccctc a                                                 21


<210>  38
<211>  7
<212>  PRT
<213>  Human

<400>  38

Gln Asp Asn Lys Arg Pro Ser 
1               5           


<210>  39
<211>  24
<212>  DNA
<213>  Human

<400>  39
caggcgtggg acaggactgt ggta                                              24


<210>  40
<211>  8
<212>  PRT
<213>  Human

<400>  40

Gln Ala Trp Asp Arg Thr Val Val 
1               5               


<210>  41
<211>  1416
<212>  DNA
<213>  Human

<400>  41
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctggt ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcagtagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcagttatat ggtatgatgg aagtaaaaaa      240

tattatgcag actccgtgaa gggccgattc accatctcca gagacaattc caaaaacaca      300

ctgtatctgc aaatgaacag actgagagcc gaggacacgg ctgtgtatta ctgtgcgaga      360

gatgggggta tagcagtatt tttacaggac aattggttcg acccctgggg ccagggaacc      420

ctggtcaccg tctctagtgc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      480

tccaggagca cctccgagag cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gctctgacca gcggcgtgca caccttccca      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

aacttcggca cccagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      720

gacaagacag ttgagcgcaa atgttgtgtc gagtgcccac cgtgcccagc accacctgtg      780

gcaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacgtgcgt ggtggtggac gtgagccacg aagaccccga ggtccagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccacg ggaggagcag      960

ttcaacagca cgttccgtgt ggtcagcgtc ctcaccgttg tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cagcccccat cgagaaaacc     1080

atctccaaaa ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacacct     1260

cccatgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1416


<210>  42
<211>  472
<212>  PRT
<213>  Human

<400>  42

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Arg Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ile Ala Val Phe Leu 
        115                 120                 125             


Gln Asp Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  43
<211>  15
<212>  DNA
<213>  Human

<400>  43
agctatggca tgcac                                                        15


<210>  44
<211>  5
<212>  PRT
<213>  Human

<400>  44

Ser Tyr Gly Met His 
1               5   


<210>  45
<211>  51
<212>  DNA
<213>  Human

<400>  45
gttatatggt atgatggaag taaaaaatat tatgcagact ccgtgaaggg c                51


<210>  46
<211>  17
<212>  PRT
<213>  Human

<400>  46

Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  45
<212>  DNA
<213>  Human

<400>  47
gatgggggta tagcagtatt tttacaggac aattggttcg acccc                       45


<210>  48
<211>  15
<212>  PRT
<213>  Human

<400>  48

Asp Gly Gly Ile Ala Val Phe Leu Gln Asp Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  49
<211>  1416
<212>  DNA
<213>  Human

<400>  49
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctggt ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcagaagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcagttatat ggtatgatgg aagtaaaaaa      240

tattatgcag actccgtgaa gggccgattc accatctcca gagacaactc caaaaacaca      300

ctgtatctgc aaatgaacag actgagagcc gaggacacgg ctgtgtatta ctgtgcgaga      360

gatgggggta tagcagtatt tttagaggac aattggttcg acccctgggg ccagggaacc      420

ctggtcaccg tctctagtgc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      480

tccaggagca cctccgagag cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gctctgacca gcggcgtgca caccttccca      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

aacttcggca cccagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      720

gacaagacag ttgagcgcaa atgttgtgtc gagtgcccac cgtgcccagc accacctgtg      780

gcaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacgtgcgt ggtggtggac gtgagccacg aagaccccga ggtccagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccacg ggaggagcag      960

ttcaacagca cgttccgtgt ggtcagcgtc ctcaccgttg tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cagcccccat cgagaaaacc     1080

atctccaaaa ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacacct     1260

cccatgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1416


<210>  50
<211>  472
<212>  PRT
<213>  Human

<400>  50

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Arg Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ile Ala Val Phe Leu 
        115                 120                 125             


Glu Asp Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  51
<211>  15
<212>  DNA
<213>  Human

<400>  51
agctatggca tgcac                                                        15


<210>  52
<211>  5
<212>  PRT
<213>  Human

<400>  52

Ser Tyr Gly Met His 
1               5   


<210>  53
<211>  51
<212>  DNA
<213>  Human

<400>  53
gttatatggt atgatggaag taaaaaatat tatgcagact ccgtgaaggg c                51


<210>  54
<211>  17
<212>  PRT
<213>  Human

<400>  54

Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  45
<212>  DNA
<213>  Human

<400>  55
gatgggggta tagcagtatt tttagaggac aattggttcg acccc                       45


<210>  56
<211>  15
<212>  PRT
<213>  Human

<400>  56

Asp Gly Gly Ile Ala Val Phe Leu Glu Asp Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  57
<211>  1416
<212>  DNA
<213>  Human

<400>  57
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg ggcagctggt ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcaggagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcagttatat ggtatgatgg aagtaaaaaa      240

tactatgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtttctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaga      360

gatgggggta tagcagcatt tttacaggac aactggttcg acccctgggg ccagggaacc      420

ctggtcaccg tctctagtgc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      480

tccaggagca cctccgagag cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gctctgacca gcggcgtgca caccttccca      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

aacttcggca cccagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      720

gacaagacag ttgagcgcaa atgttgtgtc gagtgcccac cgtgcccagc accacctgtg      780

gcaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacgtgcgt ggtggtggac gtgagccacg aagaccccga ggtccagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccacg ggaggagcag      960

ttcaacagca cgttccgtgt ggtcagcgtc ctcaccgttg tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cagcccccat cgagaaaacc     1080

atctccaaaa ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacacct     1260

cccatgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1416


<210>  58
<211>  472
<212>  PRT
<213>  Human

<400>  58

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Gly Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ile Ala Ala Phe Leu 
        115                 120                 125             


Gln Asp Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  59
<211>  15
<212>  DNA
<213>  Human

<400>  59
agctatggca tgcac                                                        15


<210>  60
<211>  5
<212>  PRT
<213>  Human

<400>  60

Ser Tyr Gly Met His 
1               5   


<210>  61
<211>  51
<212>  DNA
<213>  Human

<400>  61
gttatatggt atgatggaag taaaaaatac tatgcagact ccgtgaaggg c                51


<210>  62
<211>  17
<212>  PRT
<213>  Human

<400>  62

Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  45
<212>  DNA
<213>  Human

<400>  63
gatgggggta tagcagcatt tttacaggac aactggttcg acccc                       45


<210>  64
<211>  15
<212>  PRT
<213>  Human

<400>  64

Asp Gly Gly Ile Ala Ala Phe Leu Gln Asp Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  65
<211>  1416
<212>  DNA
<213>  Human

<400>  65
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctggt ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcaggagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcagttatat ggtatgatgg aagtaaaaaa      240

tactatgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtttctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaga      360

gatgggggta tagcagcatt tttacaggac aactggttcg acccctgggg ccagggaacc      420

ctggtcaccg tctctagtgc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      480

tccaggagca cctccgagag cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gctctgacca gcggcgtgca caccttccca      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

aacttcggca cccagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      720

gacaagacag ttgagcgcaa atgttgtgtc gagtgcccac cgtgcccagc accacctgtg      780

gcaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacgtgcgt ggtggtggac gtgagccacg aagaccccga ggtccagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccacg ggaggagcag      960

ttcaacagca cgttccgtgt ggtcagcgtc ctcaccgttg tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cagcccccat cgagaaaacc     1080

atctccaaaa ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacacct     1260

cccatgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1416


<210>  66
<211>  472
<212>  PRT
<213>  Human

<400>  66

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ile Ala Ala Phe Leu 
        115                 120                 125             


Gln Asp Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  67
<211>  15
<212>  DNA
<213>  Human

<400>  67
agctatggca tgcac                                                        15


<210>  68
<211>  5
<212>  PRT
<213>  Human

<400>  68

Ser Tyr Gly Met His 
1               5   


<210>  69
<211>  51
<212>  DNA
<213>  Human

<400>  69
gttatatggt atgatggaag taaaaaatac tatgcagact ccgtgaaggg c                51


<210>  70
<211>  17
<212>  PRT
<213>  Human

<400>  70

Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  45
<212>  DNA
<213>  Human

<400>  71
gatgggggta tagcagcatt tttacaggac aactggttcg acccc                       45


<210>  72
<211>  15
<212>  PRT
<213>  Human

<400>  72

Asp Gly Gly Ile Ala Ala Phe Leu Gln Asp Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  73
<211>  1416
<212>  DNA
<213>  Human

<400>  73
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg ggcagctggt ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcaggagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcagttatat ggtatgatgg aagtaaaaaa      240

tactatgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaga      360

gatgggggta tagcagcatt tttacaggac aactggttcg acccctgggg ccagggaacc      420

ctggtcaccg tctctagtgc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      480

tccaggagca cctccgagag cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gctctgacca gcggcgtgca caccttccca      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

aacttcggca cccagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      720

gacaagacag ttgagcgcaa atgttgtgtc gagtgcccac cgtgcccagc accacctgtg      780

gcaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacgtgcgt ggtggtggac gtgagccacg aagaccccga ggtccagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccacg ggaggagcag      960

ttcaacagca cgttccgtgt ggtcagcgtc ctcaccgttg tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cagcccccat cgagaaaacc     1080

atctccaaaa ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacacct     1260

cccatgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1416


<210>  74
<211>  472
<212>  PRT
<213>  Human

<400>  74

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Gly Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ile Ala Ala Phe Leu 
        115                 120                 125             


Gln Asp Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  75
<211>  15
<212>  DNA
<213>  Human

<400>  75
agctatggca tgcac                                                        15


<210>  76
<211>  5
<212>  PRT
<213>  Human

<400>  76

Ser Tyr Gly Met His 
1               5   


<210>  77
<211>  51
<212>  DNA
<213>  Human

<400>  77
gttatatggt atgatggaag taaaaaatac tatgcagact ccgtgaaggg c                51


<210>  78
<211>  17
<212>  PRT
<213>  Human

<400>  78

Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  45
<212>  DNA
<213>  Human

<400>  79
gatgggggta tagcagcatt tttacaggac aactggttcg acccc                       45


<210>  80
<211>  15
<212>  PRT
<213>  Human

<400>  80

Asp Gly Gly Ile Ala Ala Phe Leu Gln Asp Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  81
<211>  1416
<212>  DNA
<213>  Human

<400>  81
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctggt ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcaggagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcagttatat ggtatgatgg aagtaaaaaa      240

tactatgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaga      360

gatgggggta tagcagcatt tttacaggac aactggttcg acccctgggg ccagggaacc      420

ctggtcaccg tctctagtgc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc      480

tccaggagca cctccgagag cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gctctgacca gcggcgtgca caccttccca      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

aacttcggca cccagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg      720

gacaagacag ttgagcgcaa atgttgtgtc gagtgcccac cgtgcccagc accacctgtg      780

gcaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacgtgcgt ggtggtggac gtgagccacg aagaccccga ggtccagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccacg ggaggagcag      960

ttcaacagca cgttccgtgt ggtcagcgtc ctcaccgttg tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cagcccccat cgagaaaacc     1080

atctccaaaa ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacacct     1260

cccatgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1416


<210>  82
<211>  472
<212>  PRT
<213>  Human

<400>  82

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ile Ala Ala Phe Leu 
        115                 120                 125             


Gln Asp Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  83
<211>  15
<212>  DNA
<213>  Human

<400>  83
agctatggca tgcac                                                        15


<210>  84
<211>  5
<212>  PRT
<213>  Human

<400>  84

Ser Tyr Gly Met His 
1               5   


<210>  85
<211>  51
<212>  DNA
<213>  Human

<400>  85
gttatatggt atgatggaag taaaaaatac tatgcagact ccgtgaaggg c                51


<210>  86
<211>  17
<212>  PRT
<213>  Human

<400>  86

Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  45
<212>  DNA
<213>  Human

<400>  87
gatgggggta tagcagcatt tttacaggac aactggttcg acccc                       45


<210>  88
<211>  15
<212>  PRT
<213>  Human

<400>  88

Asp Gly Gly Ile Ala Ala Phe Leu Gln Asp Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  89
<211>  990
<212>  DNA
<213>  Human

<400>  89
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccatcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cgcgggggca      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  90
<211>  330
<212>  PRT
<213>  Human

<400>  90

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  91
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  91
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagagccca tctagtctct ctgcttccgt gggagatcgg      120

gttaccatta catgtagggc ctctcaagac attgggtcaa atctgaattg gtatcagcag      180

aaacccgaga aagcacccaa atctctgatc tatgctacat cttctctgga ttccggggtc      240

ccctcacggt tctccggttc agggagcgga accgacttca cgcttacaat ctcaagcctt      300

cagccagagg attttgctac ctactactgt ctgcagtatg ccacaagccc tctcacattt      360

gggcagggaa ccaaggtcga gattaagcgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  92
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  92

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Gly Ser Asn Leu Asn Trp Tyr Gln Gln Lys Pro Glu Lys 
    50                  55                  60                  


Ala Pro Lys Ser Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Ala Thr Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  93
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  93
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagagccca tctagtctct ctgcttccgt gggagatcgg      120

gttaccatta catgtagggc ctctcaagac attgggtcaa atctgaattg gcttcaacag      180

acatcagatg gaagtattaa acgcctgatc tacgctacat cttctctgga ttccggggtc      240

ccctcacggt tctccggttc agggagcgga accgacttca cgcttacaat ctcaagcctt      300

cagccagagg attttgctac ctactactgt ctgcagtatg ccacaagccc tctcacattt      360

gggcagggaa ccaaggtcga gattaagcgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  94
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  94

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Gly Ser Asn Leu Asn Trp Leu Gln Gln Thr Ser Asp Gly 
    50                  55                  60                  


Ser Ile Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Ala Thr Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  95
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  95
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagagccca tctagtctct ctgcttccgt gggagatcgg      120

gttaccatta catgtagggc ctctcaagac attgggtcaa atctgaattg gctccagcag      180

aaacccgaga aagcacccaa atctctgatc tatgctacat cttctctgga ttccggggtc      240

ccctcacggt tctccggttc agggagcgga accgacttca cgcttacaat ctcaagcctt      300

cagccagagg attttgctac ctactactgt ctgcagtatg ccacaagccc tctcacattt      360

gggcagggaa ccaaggtcga gattaagcgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  96
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  96

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Gly Ser Asn Leu Asn Trp Leu Gln Gln Lys Pro Glu Lys 
    50                  55                  60                  


Ala Pro Lys Ser Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Ala Thr Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  97
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  97
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagagccca tctagtctct ctgcttccgt gggagatcgg      120

gttaccatta catgtagggc ctctcaagac attgggtcaa atctgaattg gtatcagcag      180

aaacccgaga aagcacccaa aagactgatc tatgctacat cttctctgga ttccggggtc      240

ccctcacggt tctccggttc agggagcgga accgacttca cgcttacaat ctcaagcctt      300

cagccagagg attttgctac ctactactgt ctgcagtatg ccacaagccc tctcacattt      360

gggcagggaa ccaaggtcga gattaagcgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  98
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anitbody Sequence

<400>  98

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Gly Ser Asn Leu Asn Trp Tyr Gln Gln Lys Pro Glu Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Ala Thr Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  99
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  99
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagagccca tctagtctct ctgcttccgt gggagatcgg      120

gttaccatta catgtagggc ctctcaagac attgggtcaa atctgaattg gctccagcag      180

aaacccgaga aagcacccaa aagactgatc tatgctacat cttctctgga ttccggggtc      240

ccctcacggt tctccggttc agggagcgga accgacttca cgcttacaat ctcaagcctt      300

cagccagagg attttgctac ctactactgt ctgcagtatg ccacaagccc tctcacattt      360

gggcagggaa ccaaggtcga gattaagcgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  100
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  100

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Gly Ser Asn Leu Asn Trp Leu Gln Gln Lys Pro Glu Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Ala Thr Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  101
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  101
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagagccca tctagtctct ctgcttccgt gggagatcgg      120

gttaccatta catgtagggc ctctcaagac attgggtcaa atctgaattg gctccagcag      180

aaacccggca aagcacccaa aagactgatc tatgctacat cttctctgga ttccggggtc      240

ccctcacggt tctccggttc agggagcgga accgacttca cgcttacaat ctcaagcctt      300

cagccagagg attttgctac ctactactgt ctgcagtatg ccacaagccc tctcacattt      360

gggcagggaa ccaaggtcga gattaagcgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  102
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  102

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Gly Ser Asn Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Ala Thr Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  103
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  103
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagagccca tctagtctct ctgcttccgt gggagatcgg      120

gttaccatta catgtagggc ctctcaagac attgggtcaa atctgaattg gctccagcag      180

aaacccgaga aagcacccaa aagactgatc tatgctacat cttctctgga ttccggggtc      240

ccctcacggt tctccggttc acggagcgga agcgactata cgcttacaat ctcaagcctt      300

cagccagagg attttgctac ctactactgt ctgcagtatg ccacaagccc tctcacattt      360

gggcagggaa ccaaggtcga gattaagcgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  104
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  104

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Gly Ser Asn Leu Asn Trp Leu Gln Gln Lys Pro Glu Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Ala Thr Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  105
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  105
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagagccca tctagtctct ctgcttccgt gggagatcgg      120

gttaccatta catgtagggc ctctcaagac attgggtcaa atctgaattg gctccagcag      180

aaacccggca aagcacccaa aagactgatc tatgctacat cttctctgga ttccggggtc      240

ccctcacggt tctccggttc acggagcgga agcgactata cgcttacaat ctcaagcctt      300

cagccagagg attttgctac ctactactgt ctgcagtatg ccacaagccc tctcacattt      360

gggcagggaa ccaaggtcga gattaagcgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  106
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  106

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Gly Ser Asn Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Ala Thr Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  107
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  107
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaag tgcagcttgt ggagagcggt ggcggtctgg tgaagcccgg aggctcattg      120

agactctcat gcgccgcctc cggtttctct ttctcacgct atgcaatgac ttgggtgcgc      180

caggcccctg gtaaagggct ggaatgggtg tctacgatct ccgatggcgg ctcatatacg      240

tactatccag actcagagaa gaatagattc actatcagca gagacaatgc caagaacagc      300

ctctatctcc aaatgaatag tctgagggcc gaagatacag ccgtctatta ctgcgcacgg      360

cgggccgggc atatggtgac gacagatgcc atggattact ggggccaagg aaccatggtg      420

accgtctcta gtgcctccac caagggccca tcggtcttcc ccctggcgcc ctgctccagg      480

agcacctccg agagcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      540

gtgacggtgt cgtggaactc aggcgctctg accagcggcg tgcacacctt cccagctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcaacttc      660

ggcacccaga cctacacctg caacgtagat cacaagccca gcaacaccaa ggtggacaag      720

acagttgagc gcaaatgttg tgtcgagtgc ccaccgtgcc cagcaccacc tgtggcagga      780

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacgt gcgtggtggt ggacgtgagc cacgaagacc ccgaggtcca gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cacgggagga gcagttcaac      960

agcacgttcc gtgtggtcag cgtcctcacc gttgtgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtctc caacaaaggc ctcccagccc ccatcgagaa aaccatctcc     1080

aaaaccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac acctcccatg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggtaaa                                      1410


<210>  108
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Sequence

<400>  108

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ser Phe Ser Arg Tyr Ala Met Thr Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Asp Gly Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Pro Asp Ser Glu Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Ala Gly His Met Val Thr Thr 
        115                 120                 125             


Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
305                 310                 315                 320 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  109
<211>  378
<212>  PRT
<213>  Human

<400>  109

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  110
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  110
gacgattaca tcggagagaa caccacagtg gacta                                  35


<210>  111
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  111
tagtccactg tggtgttctc tccgatgtaa tcgtc                                  35


<210>  112
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  112
cacagtggac tacactttgt atgagtcttt gtgctccaag aa                          42


<210>  113
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  113
ttcttggagc acaaagactc atacaaagtg tagtccactg tg                          42


<210>  114
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  114
tggactacac tttgttcgag tctgtgtgct ccaaga                                 36


<210>  115
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  115
tcttggagca cacagactcg aacaaagtgt agtcca                                 36


<210>  116
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  116
tcttggagca cacagactcg aacaaagtgt agtcca                                 36


<210>  117
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  117
ccgcacgtcc ttcttgaagc acaaagactc gaa                                    33


<210>  118
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  118
gggcctacag cgaggccaag tcctg                                             25


<210>  119
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  119
caggacttgg cctcgctgta ggccc                                             25


<210>  120
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  120
cggccaagtc ctggatcttc ggtgtccac                                         29


<210>  121
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  121
gtggacaccg aagatccagg acttggccg                                         29


<210>  122
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  122
gtcctgggtc ttcggtgtct atttttgcaa gctcatcttt g                           41


<210>  123
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  123
caaagatgag cttgcaaaaa tagacaccga agacccagga c                           41


<210>  124
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  124
gggtcttcgg tgtccactta tgcaagctca tctt                                   34


<210>  125
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  125
aagatgagct tgcataagtg gacaccgaag accc                                   34


<210>  126
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  126
gctcctgtac agtggcctcc agaggagca                                         29


<210>  127
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  127
tgctcctctg gaggccactg tacaggagc                                         29


<210>  128
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  128
cagtgacctc cagaagagca gcagtgagc                                         29


<210>  129
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  129
gctcactgct gctcttctgg aggtcactg                                         29


<210>  130
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  130
gtgacctcca gaggaacagc agtgagcaag c                                      31


<210>  131
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  131
gcttgctcac tgctgttcct ctggaggtca c                                      31


<210>  132
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  132
tccagaggag cagcggtgag caagcgatg                                         29


<210>  133
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  133
catcgcttgc tcaccgctgc tcctctgga                                         29


<210>  134
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  134
ggagcagcag tgaggatgcg atgcgatgct c                                      31


<210>  135
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  135
gagcatcgca tcgcatcctc actgctgctc c                                      31


<210>  136
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  136
aggagcagca gtgagcaaac gatgcgatcg                                        30


<210>  137
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  137
gcatcgcatc gtttgctcac tgctgctcct                                        30


<210>  138
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  138
gcagtgagca agcgttgcga tgctctctc                                         29


<210>  139
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  139
gagagagcat cgcaacgctt gctcactgc                                         29


<210>  140
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  140
gatgcgatgc tctctcgtca cagagcatgt gga                                    33


<210>  141
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  141
tccacatgct ctgtgacgag agagcatcgc atc                                    33


<210>  142
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  142
cgatgctctc tcatctcaga gcatgtggag g                                      31


<210>  143
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  143
cctccacatg ctctgagatg agagagcatc g                                      31


<210>  144
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  144
gctctctcat cacagcgcat gtggaggcct t                                      31


<210>  145
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  145
aaggcctcca catgcgctgt gatgagagag c                                      31


<210>  146
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  146
tctctcatca cagagcaggt ggaggccttt atcac                                  35


<210>  147
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  147
gtgataaagg cctccacctg ctctgtgatg agaga                                  35


<210>  148
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  148
caacttcaac atcaccaata gcacctgtga gctca                                  35


<210>  149
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  149
tgagctcaca ggtgctattg gtgatgttga agttg                                  35


<210>  150
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  150
caacatcacc agtagcagct gtgagctcag taagc                                  35


<210>  151
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  151
gcttactgag ctcacagctg ctactggtga tgttg                                  35


<210>  152
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  152
caccagtagc acctgtgaga ccagtaagca actcaacatc                             40


<210>  153
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  153
gatgttgagt tgcttactgg tctcacaggt gctactggtg                             40


<210>  154
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  154
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  155
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  155

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  156
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  156
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagagaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  157
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated hCCR7

<400>  157

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Glu Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  158
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  158
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt atgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  159
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  159

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Tyr Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  160
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  160
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtctgt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  161
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  161

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Val Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  162
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  162
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgcttcaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  163
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  163

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Phe Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  164
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  164
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgaggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  165
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  165

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Glu Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  166
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  166
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctggatct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  167
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  167

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Ile Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  168
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  168
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcta tttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  169
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  169

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val Tyr Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  170
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  170
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttatgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  171
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  171

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Leu 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  172
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  172
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tggcctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  173
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  173

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Gly Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  174
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  174
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aagagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  175
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  175

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Lys Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  176
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  176
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggaacagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  177
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  177

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Asn Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  178
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  178
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagcg gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  179
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  179

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Gly Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  180
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  180
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgaggatgc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  181
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  181

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Asp Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  182
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  182
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaaac gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  183
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  183

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Thr Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  184
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  184
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gttgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  185
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  185

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Leu 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  186
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  186
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcgtca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  187
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  187

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Val Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  188
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  188
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatct cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  189
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  189

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Ser Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  190
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  190
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagcgcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  191
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  191

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Ala His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  192
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  192
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcaggt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  193
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  193

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu Gln Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  194
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  194
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccaatagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  195
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  195

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Asn Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  196
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  196
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcag ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  197
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  197

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Ser Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  198
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  198
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagacc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210>  199
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated hCCR7

<400>  199

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Thr Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  200
<211>  1137
<212>  DNA
<213>  Murine CCR7

<400>  200
atggacccag ggaaacccag gaaaaacgtg ctggtggtgg ctctccttgt cattttccag       60

gtgtgcttct gccaagatga ggtcaccgat gactacatcg gcgagaatac cacggtggac      120

tacaccctgt acgagtcggt gtgcttcaag aaggatgtgc ggaactttaa ggcctggttc      180

ctgcctctca tgtattctgt catctgcttc gtgggcctgc tcggcaacgg gctggtgata      240

ctgacgtaca tctatttcaa gaggctcaag accatgacgg atacctacct gctcaacctg      300

gccgtggcag acatcctttt cctcctaatt cttcccttct gggcctacag cgaagccaag      360

tcctggatct ttggcgtcta cctgtgtaag ggcatctttg gcatctataa gttaagcttc      420

ttcagcggga tgctgctgct cctatgcatc agcattgacc gctacgtagc catcgtccag      480

gccgtgtcgg ctcatcgcca ccgcgcccgc gtgcttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tgctggccct cttcctctcc atcccggagc tgctctacag cggcctccag      600

aagaacagcg gcgaggacac gctgagatgc tcactggtca gtgcccaagt ggaggccttg      660

atcaccatcc aagtggccca gatggttttt gggttcctag tgcctatgct ggctatgagt      720

ttctgctacc tcattatcat ccgtaccttg ctccaggcac gcaactttga gcggaacaag      780

gccatcaagg tgatcattgc cgtggtggta gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggctcagac ggtggccaac ttcaacatca ccaatagcag ctgcgaaacc      900

agcaagcagc tcaacattgc ctatgacgtc acctacagcc tggcctccgt ccgctgctgc      960

gtcaaccctt tcttgtatgc cttcatcggc gtcaagttcc gcagcgacct cttcaagctc     1020

ttcaaggact tgggctgcct cagccaggaa cggctccggc actggtcttc ctgccggcat     1080

gtacggaacg cgtcggtgag catggaggcg gagaccacca caaccttctc cccgtag        1137


<210>  201
<211>  378
<212>  PRT
<213>  Murine CCR7

<400>  201

Met Asp Pro Gly Lys Pro Arg Lys Asn Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Phe Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Glu Asn Thr Thr Val Asp Tyr Thr Leu Tyr Glu Ser Val Cys 
        35                  40                  45              


Phe Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Leu Met 
    50                  55                  60                  


Tyr Ser Val Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Ile 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Ile Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Glu Ala Lys Ser Trp Ile Phe Gly Val Tyr Leu 
        115                 120                 125             


Cys Lys Gly Ile Phe Gly Ile Tyr Lys Leu Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Met Leu Ala Leu Phe Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Gly Leu Gln Lys Asn Ser Gly Glu Asp Thr Leu 
        195                 200                 205             


Arg Cys Ser Leu Val Ser Ala Gln Val Glu Ala Leu Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Phe Gly Phe Leu Val Pro Met Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Ile Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Asn Ser Ser Cys Glu Thr Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Ser Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Ser Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Arg Leu 
            340                 345                 350         


Arg His Trp Ser Ser Cys Arg His Val Arg Asn Ala Ser Val Ser Met 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  202
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  202
acggtggact acaccctgtt cgagtcgttg tgcttcaa                               38


<210>  203
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  203
ttgaagcaca acgactcgaa cagggtgtag tccaccgt                               38


<210>  204
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  204
cagcggcctc cagaggagca gcagcgagga cgcgatgaga tgctc                       45


<210>  205
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  205
gagcatctca tcgcgtcctc gctgctgctc ctctggaggc cgctg                       45


<210>  206
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated Murine CCR7

<400>  206
atggacccag ggaaacccag gaaaaacgtg ctggtggtgg ctctccttgt cattttccag       60

gtgtgcttct gccaagatga ggtcaccgat gactacatcg gcgagaatac cacggtggac      120

tacaccctgt tcgagtcgtt gtgcttcaag aaggatgtgc ggaactttaa ggcctggttc      180

ctgcctctca tgtattctgt catctgcttc gtgggcctgc tcggcaacgg gctggtgata      240

ctgacgtaca tctatttcaa gaggctcaag accatgacgg atacctacct gctcaacctg      300

gccgtggcag acatcctttt cctcctaatt cttcccttct gggcctacag cgaagccaag      360

tcctggatct ttggcgtcta cctgtgtaag ggcatctttg gcatctataa gttaagcttc      420

ttcagcggga tgctgctgct cctatgcatc agcattgacc gctacgtagc catcgtccag      480

gccgtgtcgg ctcatcgcca ccgcgcccgc gtgcttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tgctggccct cttcctctcc atcccggagc tgctctacag cggcctccag      600

aagaacagcg gcgaggacac gctgagatgc tcactggtca gtgcccaagt ggaggccttg      660

atcaccatcc aagtggccca gatggttttt gggttcctag tgcctatgct ggctatgagt      720

ttctgctacc tcattatcat ccgtaccttg ctccaggcac gcaactttga gcggaacaag      780

gccatcaagg tgatcattgc cgtggtggta gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggctcagac ggtggccaac ttcaacatca ccaatagcag ctgcgaaacc      900

agcaagcagc tcaacattgc ctatgacgtc acctacagcc tggcctccgt ccgctgctgc      960

gtcaaccctt tcttgtatgc cttcatcggc gtcaagttcc gcagcgacct cttcaagctc     1020

ttcaaggact tgggctgcct cagccaggaa cggctccggc actggtcttc ctgccggcat     1080

gtacggaacg cgtcggtgag catggaggcg gagaccacca caaccttctc cccgtag        1137


<210>  207
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated Murine CCR7

<400>  207

Met Asp Pro Gly Lys Pro Arg Lys Asn Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Phe Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Glu Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Phe Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Leu Met 
    50                  55                  60                  


Tyr Ser Val Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Ile 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Ile Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Glu Ala Lys Ser Trp Ile Phe Gly Val Tyr Leu 
        115                 120                 125             


Cys Lys Gly Ile Phe Gly Ile Tyr Lys Leu Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Met Leu Ala Leu Phe Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Gly Leu Gln Lys Asn Ser Gly Glu Asp Thr Leu 
        195                 200                 205             


Arg Cys Ser Leu Val Ser Ala Gln Val Glu Ala Leu Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Phe Gly Phe Leu Val Pro Met Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Ile Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Asn Ser Ser Cys Glu Thr Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Ser Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Ser Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Arg Leu 
            340                 345                 350         


Arg His Trp Ser Ser Cys Arg His Val Arg Asn Ala Ser Val Ser Met 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  208
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated Murine CCR7

<400>  208
atggacccag ggaaacccag gaaaaacgtg ctggtggtgg ctctccttgt cattttccag       60

gtgtgcttct gccaagatga ggtcaccgat gactacatcg gcgagaatac cacggtggac      120

tacaccctgt acgagtcggt gtgcttcaag aaggatgtgc ggaactttaa ggcctggttc      180

ctgcctctca tgtattctgt catctgcttc gtgggcctgc tcggcaacgg gctggtgata      240

ctgacgtaca tctatttcaa gaggctcaag accatgacgg atacctacct gctcaacctg      300

gccgtggcag acatcctttt cctcctaatt cttcccttct gggcctacag cgaagccaag      360

tcctggatct ttggcgtcta cctgtgtaag ggcatctttg gcatctataa gttaagcttc      420

ttcagcggga tgctgctgct cctatgcatc agcattgacc gctacgtagc catcgtccag      480

gccgtgtcgg ctcatcgcca ccgcgcccgc gtgcttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tgctggccct cttcctctcc atcccggagc tgctctacag cggcctccag      600

aggagcagca gcgaggacgc gatgagatgc tcactggtca gtgcccaagt ggaggccttg      660

atcaccatcc aagtggccca gatggttttt gggttcctag tgcctatgct ggctatgagt      720

ttctgctacc tcattatcat ccgtaccttg ctccaggcac gcaactttga gcggaacaag      780

gccatcaagg tgatcattgc cgtggtggta gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggctcagac ggtggccaac ttcaacatca ccaatagcag ctgcgaaacc      900

agcaagcagc tcaacattgc ctatgacgtc acctacagcc tggcctccgt ccgctgctgc      960

gtcaaccctt tcttgtatgc cttcatcggc gtcaagttcc gcagcgacct cttcaagctc     1020

ttcaaggact tgggctgcct cagccaggaa cggctccggc actggtcttc ctgccggcat     1080

gtacggaacg cgtcggtgag catggaggcg gagaccacca caaccttctc cccgtag        1137


<210>  209
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated Murine CCR7

<400>  209

Met Asp Pro Gly Lys Pro Arg Lys Asn Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Phe Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Glu Asn Thr Thr Val Asp Tyr Thr Leu Tyr Glu Ser Val Cys 
        35                  40                  45              


Phe Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Leu Met 
    50                  55                  60                  


Tyr Ser Val Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Ile 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Ile Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Glu Ala Lys Ser Trp Ile Phe Gly Val Tyr Leu 
        115                 120                 125             


Cys Lys Gly Ile Phe Gly Ile Tyr Lys Leu Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Met Leu Ala Leu Phe Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Gly Leu Gln Arg Ser Ser Ser Glu Asp Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Val Ser Ala Gln Val Glu Ala Leu Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Phe Gly Phe Leu Val Pro Met Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Ile Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Asn Ser Ser Cys Glu Thr Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Ser Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Ser Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Arg Leu 
            340                 345                 350         


Arg His Trp Ser Ser Cys Arg His Val Arg Asn Ala Ser Val Ser Met 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  210
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  210
acggtggact acaccctgtt cgagtcgttg tgcttcaa                               38


<210>  211
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligo

<400>  211
ttgaagcaca acgactcgaa cagggtgtag tccaccgt                               38


<210>  212
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated Murine CCR7

<400>  212
atggacccag ggaaacccag gaaaaacgtg ctggtggtgg ctctccttgt cattttccag       60

gtgtgcttct gccaagatga ggtcaccgat gactacatcg gcgagaatac cacggtggac      120

tacaccctgt tcgagtcgtt gtgcttcaag aaggatgtgc ggaactttaa ggcctggttc      180

ctgcctctca tgtattctgt catctgcttc gtgggcctgc tcggcaacgg gctggtgata      240

ctgacgtaca tctatttcaa gaggctcaag accatgacgg atacctacct gctcaacctg      300

gccgtggcag acatcctttt cctcctaatt cttcccttct gggcctacag cgaagccaag      360

tcctggatct ttggcgtcta cctgtgtaag ggcatctttg gcatctataa gttaagcttc      420

ttcagcggga tgctgctgct cctatgcatc agcattgacc gctacgtagc catcgtccag      480

gccgtgtcgg ctcatcgcca ccgcgcccgc gtgcttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tgctggccct cttcctctcc atcccggagc tgctctacag cggcctccag      600

aggagcagca gcgaggacgc gatgagatgc tcactggtca gtgcccaagt ggaggccttg      660

atcaccatcc aagtggccca gatggttttt gggttcctag tgcctatgct ggctatgagt      720

ttctgctacc tcattatcat ccgtaccttg ctccaggcac gcaactttga gcggaacaag      780

gccatcaagg tgatcattgc cgtggtggta gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggctcagac ggtggccaac ttcaacatca ccaatagcag ctgcgaaacc      900

agcaagcagc tcaacattgc ctatgacgtc acctacagcc tggcctccgt ccgctgctgc      960

gtcaaccctt tcttgtatgc cttcatcggc gtcaagttcc gcagcgacct cttcaagctc     1020

ttcaaggact tgggctgcct cagccaggaa cggctccggc actggtcttc ctgccggcat     1080

gtacggaacg cgtcggtgag catggaggcg gagaccacca caaccttctc cccgtag        1137


<210>  213
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated Murine CCR7

<400>  213

Met Asp Pro Gly Lys Pro Arg Lys Asn Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Phe Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Glu Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Phe Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Leu Met 
    50                  55                  60                  


Tyr Ser Val Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Ile 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Ile Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Glu Ala Lys Ser Trp Ile Phe Gly Val Tyr Leu 
        115                 120                 125             


Cys Lys Gly Ile Phe Gly Ile Tyr Lys Leu Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Met Leu Ala Leu Phe Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Gly Leu Gln Arg Ser Ser Ser Glu Asp Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Val Ser Ala Gln Val Glu Ala Leu Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Phe Gly Phe Leu Val Pro Met Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Ile Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Asn Ser Ser Cys Glu Thr Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Ser Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Ser Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Arg Leu 
            340                 345                 350         


Arg His Trp Ser Ser Cys Arg His Val Arg Asn Ala Ser Val Ser Met 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


