                         SEQUENCE LISTING

<110>  SAMIRA, Sarit
       RACHAMIM, Nurit
       TAL, Michael
       ELIAZ, Rom
       ELLIS, Ronald
       JONES, Timothy David
       CARR, Francis Joseph
       RAKOVER, Idan
       SOLOMON, Beka
       RABINOVICH-TOIDMAN, Polina
       SOOLIMAN, Meital
 
<120>  METHODS AND COMPOSITIONS WITH IMMUNE THERAPY FOR TREATMENT OF 
       DEMENTIA

<130>  SAMIRA2A PCT

<150>  US 60/790,557
<151>  2013-03-13

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 H chain

<400>  1
atgggaagga gctggatctt tctcttcctc ctgtcaggaa ctgcaggcgt ccactctgag       60

gtccagcttc agcagtcagg acctgagctg gtgaaacctg gggcctcagt gaagatatcc      120

tgcaaggctt ctggatacac attcactgac tacaacatgc actgggtgaa gcagagccat      180

ggaaagagac ttgagtggat tggatatatt tatcctcaca atggtggtac tggctacaac      240

cagaggttca agagcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      300

gagctccgca gcctgacatc tgaggactct gcagtctatt actgtgcaag acccgggacg      360

gaggcttact ggggccaagg gactctggtc actgtctctg cagccaaaac gacaccccca      420

tctgtctatc cactggcccc tggatctgct gcccaaacta actccatggt gaccctggga      480

tgcctggtca agggctattt ccctgagcca gtgacagtga cctggaactc tggatccctg      540

tccagcggtg tgcacacctt cccagctgtc ctgcagtctg acctctacac tctgagcagc      600

tcagtgactg tcccctccag cacctggccc agcgagaccg tcacctgcaa cgttgcccac      660

ccggccagca gcaccaaggt ggacaagaaa attgtgccca gggattgtgg ttgtaagcct      720

tgcatatgta cagtcccaga agtatcatct gtcttcatct tccccccaaa gcccaaggat      780

gtgctcacca ttactctgac tcctaaggtc acgtgtgttg tggtagacat cagcaaggat      840

gatcccgagg tccagttcag ctggtttgta gatgatgtgg aggtgcacac agctcagacg      900

caaccccggg aggagcagtt caacagcact ttccgctcag tcagtgaact tcccatcatg      960

caccaggact ggctcaatgg caaggagttc aaatgcaggg tcaacagtgc agctttccct     1020

gcccccatcg agaaaaccat ctccaaaacc aagggcagac cgaaggctcc acaggtgtac     1080

accattccac ctcccaagga gcagatggcc aaggataaag tcagtctgac ctgcatgata     1140

acagacttct tccctgaaga cattactgtg gagtggcagt ggaatgggca gccagcggag     1200

aactacaaga acactcagcc catcatggac acagatggct cttacttcgt ctacagcaag     1260

ctcaatgtgc agaagagcaa ctgggaggca ggaaatactt tcacctgctc tgtgttacac     1320

gagggcctgc acaaccacca tactgagaag agcctctccc actctcctgg taaatga        1377


<210>  2
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 H chain

<400>  2

Met Gly Arg Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met His Trp Val Lys Gln Ser His Gly Lys Arg Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Tyr Pro His Asn Gly Gly Thr Gly Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Pro Gly Thr Glu Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
225                 230                 235                 240 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
        275                 280                 285             


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
    290                 295                 300                 


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
                325                 330                 335     


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            340                 345                 350         


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
        355                 360                 365             


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
    370                 375                 380                 


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
385                 390                 395                 400 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
                405                 410                 415     


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
            420                 425                 430         


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
        435                 440                 445             


Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455             


<210>  3
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 L chain

<400>  3
atggagtcac agactcaggt ctttgtatac atgttgctgt ggttgtctgg tgttgatgga       60

gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc      120

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      180

gggcaatctc ctaaaccact gatttactcg gcatcctacc ggtacagtgg agtccctgat      240

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      300

gaagacttgg cagagtattt ctgtcagcaa tttaacagct atcctctcac gttcggtgct      360

gggaccaagc tggagctgaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      705


<210>  4
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 L chain

<400>  4

Met Glu Ser Gln Thr Gln Val Phe Val Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Pro Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asn 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  5
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VH

<400>  5
gaggtccagc ttcagcagtc aggacctgag ctggtgaaac ctggggcctc agtgaagata       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaagcagagc      120

catggaaaga gacttgagtg gattggatat atttatcctc acaatggtgg tactggctac      180

aaccagaggt tcaagagcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagacccggg      300

acggaggctt actggggcca agggactctg gtcactgtct ctgca                      345


<210>  6
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VH

<400>  6

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro His Asn Gly Gly Thr Gly Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Thr Glu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  7
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VL

<400>  7
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaaccact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tttaacagct atcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VL

<400>  8

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VH CDR1

<400>  9

Asp Tyr Asn Met His 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VH CDR2

<400>  10

Tyr Ile Tyr Pro His Asn Gly Gly Thr Gly Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VH CDR3

<400>  11

Pro Gly Thr Glu Ala Tyr 
1               5       


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VL CDR1

<400>  12

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VL CDR2

<400>  13

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.100 VL CDR3

<400>  14

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  half Swedish MAP peptide

<400>  15

Ile Ser Glu Val Lys Leu Asp Ala 
1               5               


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  another MAP peptide

<400>  16

Ile Ser Glu Val Lys Leu Asp Ala Lys Leu Asp Ala 
1               5                   10          


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Swedish MAP peptide

<400>  17

Ile Ser Glu Val Asn Leu Asp Ala 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  wild type MAP peptide

<400>  18

Ile Ser Glu Val Lys Met Asp Ala 
1               5               


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Glu Val Gln Leu Gln 
1               5   


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys 
        


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg 
        


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val 
1               5                   10                  15      


Gly Asp Arg 
            


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Asp Ile Val Met Thr 
1               5   


<210>  24
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
1               5                   10                  15      


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            20                  25                  30          


Thr Asp Tyr Asn Met His Trp Val Lys Arg Leu Glu Trp Ile Gly Tyr 
        35                  40                  45              


Ile Tyr Pro His Asn Gly Gly Thr Gly Tyr Asn Gln Arg Lys Ser Lys 
    50                  55                  60                  


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu 
65                  70                  75                  80  


Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Pro 
                85                  90                  95      


Gly Thr Glu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
        115                 120                 125             


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Val Thr Val Pro Ser Ser Thr 
                165                 170                 175     


Trp Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            180                 185                 190         


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        195                 200                 205             


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    210                 215                 220                 


Pro Arg Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
225                 230                 235                 240 


Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
                245                 250                 255     


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
            260                 265                 270         


Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
        275                 280                 285             


Val Ser Leu Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
    290                 295                 300                 


Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
305                 310                 315                 320 


Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
                325                 330                 335     


Val Leu His Glu Gly 
            340     


<210>  25
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr 
            20                  25                  30          


Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln 
65                  70                  75                  80  


Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asn Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser 
        115                 120                 125             


Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val 
145                 150                 155                 160 


Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser 
            180                 185                 190         


Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys 
        195                 200                 205             


Ser Phe Asn Arg Asn Glu Cys 
    210                 215 


<210>  26
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 VH

<400>  26

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Thr Val Arg Gly Gly Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 VL

<400>  27

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 VH CDR1

<400>  28

Asn Ala Trp Met Asp 
1               5   


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 VH CDR2

<400>  29

Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Gly Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 VH CDR3

<400>  30

Thr Val Arg Gly Gly Tyr 
1               5       


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 VL CDR1

<400>  31

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 VL CDR2

<400>  32

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 VL CDR3

<400>  33

Leu Gln Tyr Asp Glu Tyr Pro Tyr Thr 
1               5                   


<210>  34
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH1

<400>  34
gaggtccagc ttgtgcagtc aggacctgag ctgaagaaac ctggggcctc agtgaagata       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaagcaggcc      120

catggaaagg gacttgagtg gattggatat atttatcctc acaatggtgg tactggctac      180

aaccagaggt tcaagagcaa ggccacattg accgtagaca agtccaccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagacccggg      300

acggaggctt actggggcca agggactctg gtcactgtct cttcc                      345


<210>  35
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH1

<400>  35

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro His Asn Gly Gly Thr Gly Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Thr Glu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  36
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH2

<400>  36
gaggtccagc ttgtgcagtc aggagctgag gtgaagaaac ctggggcctc agtgaagata       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaagcaggcc      120

catggaaagg gacttgagtg gattggatat atttatcctc acaatggtgg tactggctac      180

aaccagaggt tcaagagcaa ggccacattg accgtagaca agtccaccag cacagcctac      240

atggagctct ccagcctgcg atctgaggac tctgcagtct attactgtgc aagacccggg      300

acggaggctt actggggcca agggactctg gtcactgtct cttcc                      345


<210>  37
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH2

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro His Asn Gly Gly Thr Gly Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Thr Glu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  38
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH3

<400>  38
gaggtccagc ttgtgcagtc aggagctgag gtgaagaaac ctggggcctc agtgaagata       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaagcaggcc      120

cctggaaagg gacttgagtg gattggatat atttatcctc acaatggtgg tactggctac      180

aaccagaggt tcaagagcaa ggccacattg accgtagaca agtccaccag cacagcctac      240

atggagctct ccagcctgcg atctgaggac actgcagtct attactgtgc aagacccggg      300

acggaggctt actggggcca agggactctg gtcactgtct cttcc                      345


<210>  39
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH3

<400>  39

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro His Asn Gly Gly Thr Gly Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Thr Glu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH4

<400>  40
gaggtccagc ttgtgcagtc aggagctgag gtgaagaaac ctggggcctc agtgaagata       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaggcaggcc      120

cctggaaagg gacttgagtg gattggatat atttatcctc acaatggtgg tactggctac      180

aaccagaggt tcaagagcaa ggccacattg accgtagaca agtccaccag cacagcctac      240

atggagctct ccagcctgcg atctgaggac actgcagtct attactgtgc aagacccggg      300

acggaggctt actggggcca agggactctg gtcactgtct cttcc                      345


<210>  41
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH4

<400>  41

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro His Asn Gly Gly Thr Gly Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Thr Glu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  42
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH5

<400>  42
gaggtccagc ttgtgcagtc aggagctgag gtgaagaaac ctggggcctc agtgaaggtg       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaggcaggcc      120

cctggaaagg gacttgagtg gattggatat atttatcctc acaatggtgg tactggctac      180

aaccagaggt tcaagagcaa ggccacaatc accgtagaca agtccaccag cacagcctac      240

atggagctct ccagcctgcg atctgaggac actgcagtct attactgtgc aagacccggg      300

acggaggctt actggggcca agggactctg gtcactgtct cttcc                      345


<210>  43
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VH5

<400>  43

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro His Asn Gly Gly Thr Gly Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Thr Glu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  44
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VL1

<400>  44
gacattgtga tgacccagtc tccatcattc atgtccgcct cagtaggaga cagggtcacc       60

atcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggaaggctc ctaaaccact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagctc tctgcagtct      240

gaagacgtgg cagagtattt ctgtcagcaa tttaacagct atcctctcac gttcggtggc      300

gggaccaagg tggagattaa a                                                321


<210>  45
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VL1

<400>  45

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Glu Tyr Phe Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  46
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VL2

<400>  46
gacattgtga tgacccagtc tccatcatcc atgtccgcct cagtaggaga cagggtcacc       60

atcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggaaggctc ctaaaccact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagctc tctgcaggct      240

gaagacgtgg cagagtattt ctgtcagcaa tttaacagct atcctctcac gttcggtggc      300

gggaccaagg tggagattaa a                                                321


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VL2

<400>  47

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Glu Tyr Phe Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  48
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VL3

<400>  48
gacattgtga tgacccagtc tccatcatcc atgtccgcct cagtaggaga cagggtcacc       60

atcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggaaggctc ctaaaccact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcagcg gcagtggatc tgggacagat ttcactctca ccatcagctc tctgcaggct      240

gaagacgtgg cagagtattt ctgtcagcaa tttaacagct atcctctcac gttcggtggc      300

gggaccaagg tggagattaa a                                                321


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VL3

<400>  49

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Glu Tyr Phe Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  50
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VL4

<400>  50
gacattcaga tgacccagtc tccatcatcc atgtccgcct cagtaggaga cagggtcacc       60

atcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggaaggctc ctaaaccact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcagcg gcagtggatc tgggacagat ttcactctca ccatcagctc tctgcaggct      240

gaagacgtgg cagagtattt ctgtcagcaa tttaacagct atcctctcac gttcggtggc      300

gggaccaagg tggagattaa a                                                321


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  VL4

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Glu Tyr Phe Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  52
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 H chain

<400>  52

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr 
65                  70                  75                  80  


Tyr Gly Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Ala Thr Val Arg Gly Gly Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
225                 230                 235                 240 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                325                 330                 335     


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        355                 360                 365             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    370                 375                 380                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
385                 390                 395                 400 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
                405                 410                 415     


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460 


<210>  53
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 H chain

<400>  53
atgtacttgg gactgaacta tgtattcata gtttttctct taaatggtgt ccagagtgaa       60

gtgaagcttg aggagtctgg aggaggcttg gtgcaacctg gaggatccat gaaactctct      120

tgtgctgcct ctggattcac ttttagtaac gcctggatgg actgggtccg ccagtctcca      180

gagaaggggc ttgagtgggt tgctgaaatt agaagcaaag ctaataatca tgcaacatac      240

tatggtgagt ctgtgaaagg gaggttcacc atctcaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacagttt aagagctgaa gacactggca tttattactg taccgcaact      360

gtgagagggg gctactgggg ccaaggcacc actctcacag tctcctcagc caaaacgaca      420

cccccatctg tctatccact ggcccctgga tctgctgccc aaactaactc catggtgacc      480

ctgggatgcc tggtcaaggg ctatttccct gagccagtga cagtgacctg gaactctgga      540

tccctgtcca gcggtgtgca caccttccca gctgtcctgc agtctgacct ctacactctg      600

agcagctcag tgactgtccc ctccagcacc tggcccagcg agaccgtcac ctgcaacgtt      660

gcccacccgg ccagcagcac caaggtggac aagaaaattg tgcccaggga ttgtggttgt      720

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc      780

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc      840

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      900

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      960

atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa cagtgcagct     1020

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag     1080

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc     1140

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca     1200

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac     1260

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg     1320

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa     1380

tga                                                                   1383


<210>  54
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 L chain

<400>  54

Met Asp Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Asp Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
                165                 170                 175     


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
        195                 200                 205             


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
    210                 215                 220                 


Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235     


<210>  55
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  F5.87 L chain

<400>  55
atggacatga ggacccctgc tcagtttctt ggaatcttgt tgctctggtt tccaggtatc       60

aaatgtgaca tcaagatgac ccagtctcca tcttccatgt atgcatctct aggagagaga      120

gtcactatca cttgcaaggc gagtcaggac attaatagct atttaagctg gttccagcag      180

aaaccaggga aatctcctaa gaccctgatc tatcgtgcaa acagattggt agatggggtc      240

ccatcaaggt tcagtggcag tggatctggg caagattatt ctctcaccat cagcagcctg      300

gagtatgaag atatgggaat ttattattgt ctacagtatg atgagtatcc gtacacattc      360

ggagggggga ccaagctgga aataaaacgg gctgatgctg caccaactgt atccatcttc      420

ccaccatcca gtgagcagtt aacatctgga ggtgcctcag tcgtgtgctt cttgaacaac      480

ttctacccca aagacatcaa tgtcaagtgg aagattgatg gcagtgaacg acaaaatggc      540

gtcctgaaca gttggactga tcaggacagc aaagacagca cctacagcat gagcagcacc      600

ctcacgttga ccaaggacga gtatgaacga cataacagct atacctgtga ggccactcac      660

aagacatcaa cttcacccat tgtcaagagc ttcaacagga atgagtgtta g               711


<210>  56
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Consensus mouse single sequences H chain

<400>  56

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser 
            


<210>  57
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Consensus mouse single sequences L chain

<400>  57

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys 
            20  


