<110>      Baum, James A.
           Christian, Allen T
           Evdokimov, Artem
           Moshiri, Farhad
           Weaver, Lisa M.
           Zhang, Haitao


<120>      COMPOSITIONS AND METHODS FOR THE PRODUCTION AND DELIVERY OF DOUBLE STRANDED RNA

<130>      P34118WO00

<140>      61/793,506
<141>      2013-03-15

<160>      23

<210>      1
<211>      379
<212>      DNA
<213>      Leptinotarsa decemlineata

<400>      1

cgtaaccgcg gtttgtttcc accctgaact acctgtggct ctcacaggca gcgaagatgg   60

taccgttaga gtttggcata cgaatacaca cagattagag aattgtttga attatgggtt  120

cgagagagtg tggaccattt gttgcttgaa gggttcgaat aatgtttctc tggggtatga  180

cgagggcagt atattagtga aagttggaag agaagaaccg gcagttagta tggatgccag  240

tggcggtaaa ataatttggg caaggcactc ggaattacaa caagctaatt tgaaggcgct  300

gccagaaggt ggagaaataa gagatgggga gcgtttacct gtctctgtaa aagatatggg  360

agcatgtgaa atataccct                                               379


<210>      2
<211>      713
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      2

gggtacctgt ggctctcaca ggcagcgaag atggtaccgt tagagtttgg catacgaata   60

cacacagatt agagaattgt ttgaattatg ggttcgagag agtgtggacc atttgttgct  120

tgaagggttc gaataatgtt tctctggggt atgacgaggg cagtatatta gtgaaagttg  180

gaagagaaga accggcagtt agtatggatg ccagtggcgg taaaataatt tgggcaaggc  240

actcggaatt acaacaagct aatttgaagg cgctgccaga aggaagtact gcgatcgcgt  300

taacgcttta tcacgatacc ttctaccaca tatcactaac aacatcaaca ctcatcactc  360

tcgacgacat ccactcgatc actactctca cacgaccgat taactcctca tccacgcggc  420

cgcctgcagg agcccttctg gcagcgcctt caaattagct tgttgtaatt ccgagtgcct  480

tgcccaaatt attttaccgc cactggcatc catactaact gccggttctt ctcttccaac  540

tttcactaat atactgccct cgtcataccc cagagaaaca ttattcgaac ccttcaagca  600

acaaatggtc cacactctct cgaacccata attcaaacaa ttctctaatc tgtgtgtatt  660

cgtatgccaa actctaacgg taccatcttc gctgcctgtg agagccacag gta         713


<210>      3
<211>      844
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      3

taatacgact cactataggg tacctgtggc tctcacaggc agcgaagatg gtaccgttag   60

agtttggcat acgaatacac acagattaga gaattgtttg aattatgggt tcgagagagt  120

gtggaccatt tgttgcttga agggttcgaa taatgtttct ctggggtatg acgagggcag  180

tatattagtg aaagttggaa gagaagaacc ggcagttagt atggatgcca gtggcggtaa  240

aataatttgg gcaaggcact cggaattaca acaagctaat ttgaaggcgc tgccagaagg  300

aagtactgcg atcgcgttaa cgctttatca cgataccttc taccacatat cactaacaac  360

atcaacactc atcactctcg acgacatcca ctcgatcact actctcacac gaccgattaa  420

ctcctcatcc acgcggccgc ctgcaggagc ccttctggca gcgccttcaa attagcttgt  480

tgtaattccg agtgccttgc ccaaattatt ttaccgccac tggcatccat actaactgcc  540

ggttcttctc ttccaacttt cactaatata ctgccctcgt cataccccag agaaacatta  600

ttcgaaccct tcaagcaaca aatggtccac actctctcga acccataatt caaacaattc  660

tctaatctgt gtgtattcgt atgccaaact ctaacggtac catcttcgct gcctgtgaga  720

gccacaggta aagcttgcca tctgttttct tgcaagatca gctgagcaat aactagcata  780

accccttggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc  840

cgga                                                               844


<210>      4
<211>      764
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      4

taatacgact cactataggg atccatgata tcgtgaacat catctacatt caaattctta   60

tgagctttct taagggcatc tgcagcattt ttcatagaat ctaatacagc agtatttgtg  120

ctagctcctt cgagggcttc cctctgcatt tcaatagttg taagggttcc atctatttgt  180

agttgggtct tttccaatcg tttcttcttt ttgagggctt ggagtgcaac tcttttattt  240

ttcgacgcat ttttctttgc aagtactgcg atcgcgttaa cgctttatca cgataccttc  300

taccacatat cactaacaac atcaacactc atcactctcg acgacatcca ctcgatcact  360

actctcacac gaccgattaa ctcctcatcc acgcggccgc ctgcaggagc gcaaagaaaa  420

atgcgtcgaa aaataaaaga gttgcactcc aagccctcaa aaagaagaaa cgattggaaa  480

agacccaact acaaatagat ggaaccctta caactattga aatgcagagg gaagccctcg  540

aaggagctag cacaaatact gctgtattag attctatgaa aaatgctgca gatgccctta  600

agaaagctca taagaatttg aatgtagatg atgttcacga tatcatggat aagcttgcca  660

tctgttttct tgcaagatca gctgagcaat aactagcata accccttggg gcctctaaac  720

gggtcttgag gggttttttg ctgaaaggag gaactatatc cgga                   764


<210>      5
<211>      48
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      5

ctagcataac cccttggggc ctctaaacgg gtcttgaggg gttttttg                48


<210>      6
<211>      10
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      6

catctgtttt                                                          10


<210>      7
<211>      39
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      7

ctcatgcttg ccatctgttt tcttgcaagt cagatggga                          39


<210>      8
<211>      65
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      8

ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt atctgttgtt   60

tgtcg                                                               65


<210>      9
<211>      45
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      9

ttaagcagaa ggccatcctg acggatggcc tttttgcgtt tctac                   45


<210>      10
<211>      34
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      10

ctgtgtccct atctgttaca gtctcctaaa gtat                               34


<210>      11
<211>      22
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      11

ccccgcttcg gcggggtttt tt                                            22


<210>      12
<211>      31
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      12

ccccgcccct gacagggcgg ggtttttttt t                                  31


<210>      13
<211>      106
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      13

catctgtttt cttgcaagat cagctgagca ataactagca taaccccttg gggcctctaa   60

acgggtcttg aggggttttt tgctgaaagg aggaactata tccgga                 106


<210>      14
<211>      65
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      14

ggggtcatag caacatctgg cattttgttc tcttgcagga acaaaatgcc agatgttgct   60

atgac                                                               65


<210>      15
<211>      633
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      15

gggatccatg atatcgtgaa catcatctac attcaaattc ttatgagctt tcttaagggc   60

atctgcagca tttttcatag aatctaatac agcagtattt gtgctagctc cttcgagggc  120

ttccctctgc atttcaatag ttgtaagggt tccatctatt tgtagttggg tcttttccaa  180

tcgtttcttc tttttgaggg cttggagtgc aactctttta tttttcgacg catttttctt  240

tgcaagtact gcgatcgcgt taacgcttta tcacgatacc ttctaccaca tatcactaac  300

aacatcaaca ctcatcactc tcgacgacat ccactcgatc actactctca cacgaccgat  360

taactcctca tccacgcggc cgcctgcagg agcgcaaaga aaaatgcgtc gaaaaataaa  420

agagttgcac tccaagccct caaaaagaag aaacgattgg aaaagaccca actacaaata  480

gatggaaccc ttacaactat tgaaatgcag agggaagccc tcgaaggagc tagcacaaat  540

actgctgtat tagattctat gaaaaatgct gcagatgccc ttaagaaagc tcataagaat  600

ttgaatgtag atgatgttca cgatatcatg gat                               633


<210>      16
<211>      106
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      16

catctgtttt cttgcaagat cagctgagca ataactagca taaccccttg gggcctctaa   60

acgggtcttg aggggttttt tgctgaaagg aggaactata tccgga                 106


<210>      17
<211>      209
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      17

aagcttgcct agcataaccc cttggggcct ctaaacgggt cttgaggggt tttttgttaa   60

gcagaaggcc atcctgacgg atggcctttt tgcgtttcta cgccatctgt tttcttgcaa  120

gatcagctga gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt  180

ttttgctgaa aggaggaact atatccgga                                    209


<210>      18
<211>      209
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      18

aagcttgctt aagcagaagg ccatcctgac ggatggcctt tttgcgtttc tacctagcat   60

aaccccttgg ggcctctaaa cgggtcttga ggggtttttt ggccatctgt tttcttgcaa  120

gatcagctga gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt  180

ttttgctgaa aggaggaact atatccgga                                    209


<210>      19
<211>      161
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      19

aagcttgctt aagcagaagg ccatcctgac ggatggcctt tttgcgtttc tacgccatct   60

gttttcttgc aagatcagct gagcaataac tagcataacc ccttggggcc tctaaacggg  120

tcttgagggg ttttttgctg aaaggaggaa ctatatccgg a                      161


<210>      20
<211>      944
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      20

gatgatgtcg gactttccta atttgtcttc gatgatttga ttgctagtga ttggcaccct   60

ttggccgttc accttggcga aacctctctt ataaatcagt tctctgacag atttcaagtt  120

agggtatccc caagtgatgt aaggttcgca tattctgagc atgttgatgg tagctttgtt  180

gagcttgaca aagacaccat tgttgatttg aaggagccgg aacaattgga gaaccttgcg  240

tactttagga gctactttgt tgataccctt tatacgaatt acgaatgcca acttggcttc  300

agcgggaacg taaaagtttc ctctggtttt agcttgtcgg atcaacctaa cttcatctct  360

ttctttgagc cggtattctt taacatactg ttcggccaag tactgcgatc gcgttaacgc  420

tttatcacga taccttctac cacatatcac taacaacatc aacactcatc atctagactc  480

tcgacgacat ccactcgatc actactctca cacgaccgat taactcctca tccacgcggc  540

cgcgagcggc cgaacagtat gttaaagaat accggctcaa agaaagagat gaagttaggt  600

tgatccgaca agctaaaacc agaggaaact tttacgttcc cgctgaagcc aagttggcat  660

tcgtaattcg tataaagggt atcaacaaag tagctcctaa agtacgcaag gttctccaat  720

tgttccggct ccttcaaatc aacaatggtg tctttgtcaa gctcaacaaa gctaccatca  780

acatgctcag aatatgcgaa ccttacatca cttggggata ccctaacttg aaatctgtca  840

gagaactgat ttataagaga ggtttcgcca aggtgaacgg ccaaagggtg ccaatcacta  900

gcaatcaaat catcgaagac aaattaggaa agtccgacat catc                   944


<210>      21
<211>      139
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      21

aagctttaac ccctcaggac ccctaaacgg gtcttgaggg gtttctcagc tgatcttgtt   60

ttcttgcaag atcagctgag caataactag cacaacccct caggacctct aaacgggtct  120

tgaggggttg tgctgaaag                                               139


<210>      22
<211>      169
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      22

ggaaacgaca ggtgctgaaa gcgagctttt tggcctctgt cgtttcccat tacgccacgg   60

tacataaagt aaccgtggcg taatgcctga aaaaaacggc ctgacgtgaa tcaagcaatt  120

tttttcaggg cgcactaaaa gggcatcatt tgatgccctt tttgcacgc              169


<210>      23
<211>      170
<212>      DNA
<213>      artificial sequence

<220>      
<223>      synthetic

<400>      23

ggcaccgaca ggggccagaa gcgagctttc tggcctctgt cggtgcccgc cacgccacgg   60

tacataaagt accgtggcgt ggcgcctggc gcgccggctt gacgtgaatc aagccggcgc  120

gccagggcgc actcgcgcgg gcatcatttg atgcccgcgc gagtgcacgc             170
