                               SEQUENCE LISTING

<110> THE JACKSON LABORATORY
      WA XIAN
 
<120> TREATMENT OF INFLAMMATORY DISEASES

<130> 122854-00220

<140> PCT/US2014/025776
<141> 2014-03-13

<150> 61/793,110
<151> 2013-03-15

<150> 61/788,602
<151> 2013-03-15

<160> 56    

<170> PatentIn version 3.5

<210> 1
<211> 209
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Ser Thr Ile Leu Leu Phe Cys Leu Leu Gly Ser Thr Arg Ser 
1               5                   10                  15      


Leu Pro Gln Leu Lys Pro Ala Leu Gly Leu Pro Pro Thr Lys Leu Ala 
            20                  25                  30          


Pro Asp Gln Gly Thr Leu Pro Asn Gln Gln Gln Ser Asn Gln Val Phe 
        35                  40                  45              


Pro Ser Leu Ser Leu Ile Pro Leu Thr Gln Met Leu Thr Leu Gly Pro 
    50                  55                  60                  


Asp Leu His Leu Leu Asn Pro Ala Ala Gly Met Thr Pro Gly Thr Gln 
65                  70                  75                  80  


Thr His Pro Leu Thr Leu Gly Gly Leu Asn Val Gln Gln Gln Leu His 
                85                  90                  95      


Pro His Val Leu Pro Ile Phe Val Thr Gln Leu Gly Ala Gln Gly Thr 
            100                 105                 110         


Ile Leu Ser Ser Glu Glu Leu Pro Gln Ile Phe Thr Ser Leu Ile Ile 
        115                 120                 125             


His Ser Leu Phe Pro Gly Gly Ile Leu Pro Thr Ser Gln Ala Gly Ala 
    130                 135                 140                 


Asn Pro Asp Val Gln Asp Gly Ser Leu Pro Ala Gly Gly Ala Gly Val 
145                 150                 155                 160 


Asn Pro Ala Thr Gln Gly Thr Pro Ala Gly Arg Leu Pro Thr Pro Ser 
                165                 170                 175     


Gly Thr Asp Asp Asp Phe Ala Val Thr Thr Pro Ala Gly Ile Gln Arg 
            180                 185                 190         


Ser Thr His Ala Ile Glu Glu Ala Thr Thr Glu Ser Ala Asn Gly Ile 
        195                 200                 205             


Gln 
    


<210> 2
<211> 1072
<212> DNA
<213> Homo sapiens

<400> 2
aatttttcac cagagtaaac ttgagaaacc aactggacct tgagtattgt acattttgcc       60

tcgtggaccc aaaggtagca atctgaaaca tgaggagtac gattctactg ttttgtcttc      120

taggatcaac tcggtcatta ccacagctca aacctgcttt gggactccct cccacaaaac      180

tggctccgga tcagggaaca ctaccaaacc aacagcagtc aaatcaggtc tttccttctt      240

taagtctgat accattaaca cagatgctca cactggggcc agatctgcat ctgttaaatc      300

ctgctgcagg aatgacacct ggtacccaga cccacccatt gaccctggga gggttgaatg      360

tacaacagca actgcaccca catgtgttac caatttttgt cacacaactt ggagcccagg      420

gcactatcct aagctcagag gaattgccac aaatcttcac gagcctcatc atccattcct      480

tgttcccggg aggcatcctg cccaccagtc aggcaggggc taatccagat gtccaggatg      540

gaagccttcc agcaggagga gcaggtgtaa atcctgccac ccagggaacc ccagcaggcc      600

gcctcccaac tcccagtggc acagatgacg actttgcagt gaccacccct gcaggcatcc      660

aaaggagcac acatgccatc gaggaagcca ccacagaatc agcaaatgga attcagtaag      720

ctgtttcaaa ttttttcaac taagctgcct cgaatttggt gatacatgtg aatctttatc      780

attgattata ttatggaata gattgagaca cattggatag tcttagaaga aattaattct      840

taatttacct gaaaatattc ttgaaatttc agaaaatatg ttctatgtag agaatcccaa      900

cttttaaaaa caataattca atggataaat ctgtctttga aatataacat tatgctgcct      960

ggatgatatg catattaaaa catatttgga aaactggaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1072


<210> 3
<211> 1075
<212> PRT
<213> Homo sapiens

<400> 3
Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu 
1               5                   10                  15      


Leu Cys Gly Ser Ile Thr Leu Ala Leu Gly Asn Ala Gln Lys Leu Pro 
            20                  25                  30          


Lys Gly Lys Arg Pro Asn Leu Lys Val His Ile Asn Thr Thr Ser Asp 
        35                  40                  45              


Ser Ile Leu Leu Lys Phe Leu Arg Pro Ser Pro Asn Val Lys Leu Glu 
    50                  55                  60                  


Gly Leu Leu Leu Gly Tyr Gly Ser Asn Val Ser Pro Asn Gln Tyr Phe 
65                  70                  75                  80  


Pro Leu Pro Ala Glu Gly Lys Phe Thr Glu Ala Ile Val Asp Ala Glu 
                85                  90                  95      


Pro Lys Tyr Leu Ile Val Val Arg Pro Ala Pro Pro Pro Ser Gln Lys 
            100                 105                 110         


Lys Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro Leu Gln Leu Val 
        115                 120                 125             


Val Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser Trp Gly Phe Leu 
    130                 135                 140                 


Ile Asn Pro His His Asp Trp Thr Leu Pro Ser His Cys Pro Asn Asp 
145                 150                 155                 160 


Arg Phe Tyr Thr Ile Arg Tyr Arg Glu Lys Asp Lys Glu Lys Lys Trp 
                165                 170                 175     


Ile Phe Gln Ile Cys Pro Ala Thr Glu Thr Ile Val Glu Asn Leu Lys 
            180                 185                 190         


Pro Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn Val Glu Gly Gly 
        195                 200                 205             


Ile Trp Ser Lys Ile Phe Asn His Lys Thr Val Val Gly Ser Lys Lys 
    210                 215                 220                 


Val Asn Gly Lys Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro 
225                 230                 235                 240 


Ala Tyr Val Pro Arg Lys Leu Ile Pro Ile Thr Ile Ile Lys Gln Val 
                245                 250                 255     


Ile Gln Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala 
            260                 265                 270         


Pro Leu Gly Gly Val Ile Leu Val His Leu Ile Ile Pro Gly Leu Asn 
        275                 280                 285             


Glu Thr Thr Val Lys Leu Pro Ala Ser Leu Met Phe Glu Ile Ser Asp 
    290                 295                 300                 


Ala Leu Lys Thr Gln Leu Ala Lys Asn Glu Thr Leu Ala Leu Pro Ala 
305                 310                 315                 320 


Glu Ser Lys Thr Pro Glu Val Glu Lys Ile Ser Ala Arg Pro Thr Thr 
                325                 330                 335     


Val Thr Pro Glu Thr Val Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser 
            340                 345                 350         


Ala Leu Asp Val Ser Glu Thr Thr Leu Ala Ser Ser Glu Lys Pro Trp 
        355                 360                 365             


Ile Val Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu Gln Pro 
    370                 375                 380                 


Gln Thr Ala Thr Tyr Asp Val Phe Ser Ser Pro Thr Thr Ser Asp Glu 
385                 390                 395                 400 


Pro Glu Ile Ser Asp Ser Tyr Thr Ala Thr Ser Asp Arg Ile Leu Asp 
                405                 410                 415     


Ser Ile Pro Pro Lys Thr Ser Arg Thr Leu Glu Gln Pro Arg Ala Thr 
            420                 425                 430         


Leu Ala Pro Ser Glu Thr Pro Phe Val Pro Gln Lys Leu Glu Ile Phe 
        435                 440                 445             


Thr Ser Pro Glu Met Gln Pro Thr Thr Pro Ala Pro Gln Gln Thr Thr 
    450                 455                 460                 


Ser Ile Pro Ser Thr Pro Lys Arg Arg Pro Arg Pro Lys Pro Pro Arg 
465                 470                 475                 480 


Thr Lys Pro Glu Arg Thr Thr Ser Ala Gly Thr Ile Thr Pro Lys Ile 
                485                 490                 495     


Ser Lys Ser Pro Glu Pro Thr Trp Thr Thr Pro Ala Pro Gly Lys Thr 
            500                 505                 510         


Gln Phe Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val Thr 
        515                 520                 525             


His Thr Lys Pro Ala Pro Lys Gln Thr Pro Arg Ala Pro Pro Lys Pro 
    530                 535                 540                 


Lys Thr Ser Pro Arg Pro Arg Ile Pro Gln Thr Gln Pro Val Pro Lys 
545                 550                 555                 560 


Val Pro Gln Arg Val Thr Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu 
                565                 570                 575     


Val Ser Tyr Thr Thr Pro Ala Pro Lys Asp Val Leu Leu Pro His Lys 
            580                 585                 590         


Pro Tyr Pro Glu Val Ser Gln Ser Glu Pro Ala Pro Leu Glu Thr Arg 
        595                 600                 605             


Gly Ile Pro Phe Ile Pro Met Ile Ser Pro Ser Pro Ser Gln Glu Glu 
    610                 615                 620                 


Leu Gln Thr Thr Leu Glu Glu Thr Asp Gln Ser Thr Gln Glu Pro Phe 
625                 630                 635                 640 


Thr Thr Lys Ile Pro Arg Thr Thr Glu Leu Ala Lys Thr Thr Gln Ala 
                645                 650                 655     


Pro His Arg Phe Tyr Thr Thr Val Arg Pro Arg Thr Ser Asp Lys Pro 
            660                 665                 670         


His Ile Arg Pro Gly Val Lys Gln Ala Pro Arg Pro Ser Gly Ala Asp 
        675                 680                 685             


Arg Asn Val Ser Val Asp Ser Thr His Pro Thr Lys Lys Pro Gly Thr 
    690                 695                 700                 


Arg Arg Pro Pro Leu Pro Pro Arg Pro Thr His Pro Arg Arg Lys Pro 
705                 710                 715                 720 


Leu Pro Pro Asn Asn Val Thr Gly Lys Pro Gly Ser Ala Gly Ile Ile 
                725                 730                 735     


Ser Ser Gly Pro Ile Thr Thr Pro Pro Leu Arg Ser Thr Pro Arg Pro 
            740                 745                 750         


Thr Gly Thr Pro Leu Glu Arg Ile Glu Thr Asp Ile Lys Gln Pro Thr 
        755                 760                 765             


Val Pro Ala Ser Gly Glu Glu Leu Glu Asn Ile Thr Asp Phe Ser Ser 
    770                 775                 780                 


Ser Pro Thr Arg Glu Thr Asp Pro Leu Gly Lys Pro Arg Phe Lys Gly 
785                 790                 795                 800 


Pro His Val Arg Tyr Ile Gln Lys Pro Asp Asn Ser Pro Cys Ser Ile 
                805                 810                 815     


Thr Asp Ser Val Lys Arg Phe Pro Lys Glu Glu Ala Thr Glu Gly Asn 
            820                 825                 830         


Ala Thr Ser Pro Pro Gln Asn Pro Pro Thr Asn Leu Thr Val Val Thr 
        835                 840                 845             


Val Glu Gly Cys Pro Ser Phe Val Ile Leu Asp Trp Glu Lys Pro Leu 
    850                 855                 860                 


Asn Asp Thr Val Thr Glu Tyr Glu Val Ile Ser Arg Glu Asn Gly Ser 
865                 870                 875                 880 


Phe Ser Gly Lys Asn Lys Ser Ile Gln Met Thr Asn Gln Thr Phe Ser 
                885                 890                 895     


Thr Val Glu Asn Leu Lys Pro Asn Thr Ser Tyr Glu Phe Gln Val Lys 
            900                 905                 910         


Pro Lys Asn Pro Leu Gly Glu Gly Pro Val Ser Asn Thr Val Ala Phe 
        915                 920                 925             


Ser Thr Glu Ser Ala Asp Pro Arg Val Ser Glu Pro Val Ser Ala Gly 
    930                 935                 940                 


Arg Asp Ala Ile Trp Thr Glu Arg Pro Phe Asn Ser Asp Ser Tyr Ser 
945                 950                 955                 960 


Glu Cys Lys Gly Lys Gln Tyr Val Lys Arg Thr Trp Tyr Lys Lys Phe 
                965                 970                 975     


Val Gly Val Gln Leu Cys Asn Ser Leu Arg Tyr Lys Ile Tyr Leu Ser 
            980                 985                 990         


Asp Ser Leu Thr Gly Lys Phe Tyr  Asn Ile Gly Asp Gln  Arg Gly His 
        995                 1000                 1005             


Gly Glu  Asp His Cys Gln Phe  Val Asp Ser Phe Leu  Asp Gly Arg 
    1010                 1015                 1020             


Thr Gly  Gln Gln Leu Thr Ser  Asp Gln Leu Pro Ile  Lys Glu Gly 
    1025                 1030                 1035             


Tyr Phe  Arg Ala Val Arg Gln  Glu Pro Val Gln Phe  Gly Glu Ile 
    1040                 1045                 1050             


Gly Gly  His Thr Gln Ile Asn  Tyr Val Gln Trp Tyr  Glu Cys Gly 
    1055                 1060                 1065             


Thr Thr  Ile Pro Gly Lys Trp  
    1070                 1075 


<210> 4
<211> 4488
<212> DNA
<213> Homo sapiens

<400> 4
gtgcagccgc ccgcctctgt cactgggaga cagtccactt aaatgcagct ccagggttgc       60

gaggcaccca ccagcatcat tccccatgcg aggtggcaaa tgcaacatgc tctccagttt      120

ggggtgtcta cttctctgtg gaagtattac actagccctg ggaaatgcac agaaattgcc      180

aaaaggtaaa aggccaaacc tcaaagtcca catcaatacc acaagtgact ccatcctctt      240

gaagttcttg cgtccaagtc caaatgtaaa gcttgaaggt cttctcctgg gatatggcag      300

caatgtatca ccaaaccagt acttccctct tcccgctgaa gggaaattca cagaagctat      360

agttgatgca gagccgaaat atctgatagt tgtgcgacct gctccacctc caagtcaaaa      420

gaagtcatgt tcaggtaaaa ctcgttctcg caaacctctg cagctggtgg ttggcactct      480

gacaccgagc tcggtcttcc tgtcctgggg tttcctcatc aacccacacc atgactggac      540

attgccaagt cactgtccca atgacagatt ttatacaatt cgctatcgag aaaaggataa      600

agaaaagaag tggatttttc aaatctgtcc agccactgaa acaattgtgg aaaacctaaa      660

gcccaacaca gtttatgaat ttggagtgaa agacaatgtg gaaggtggaa tttggagtaa      720

gattttcaat cacaagactg ttgttggaag taaaaaagta aatgggaaaa tccaaagtac      780

ctatgaccaa gaccacacag tgccagcata tgtcccaagg aaactaatcc caataacaat      840

catcaagcaa gtgattcaga atgttactca caaggattca gctaaatccc cagaaaaagc      900

tccactggga ggagtgatac tagtccacct tattattcca ggtcttaatg aaactactgt      960

aaaacttcct gcatccctaa tgtttgagat ttcagatgca ctcaagacac aattagctaa     1020

gaatgaaacc ttggcattac ctgccgaatc taaaacacca gaggttgaaa aaatctcagc     1080

acgacccaca acagtgactc ctgaaacagt tccaagaagc actaaaccca ctacgtctag     1140

tgcattagat gtttcagaaa caacactggc ttcaagtgaa aagccatgga ttgtgcctac     1200

agctaaaata tctgaagatt ccaaagttct gcagcctcaa actgcaactt atgatgtttt     1260

ctcaagccct acaacatcag atgagcctga gatatcagat tcctacacag caacaagtga     1320

tcgtattctg gattctatcc cacctaaaac ttctagaact cttgaacagc caagggcaac     1380

actggctcca agtgaaacac catttgttcc tcaaaaactg gaaatcttta ccagtccaga     1440

aatgcagcct acgacacctg ctccccagca aactacatct atcccttcta cacctaaacg     1500

acgcccccgg cccaaaccgc caagaaccaa acctgaaaga accacaagtg ccggaacaat     1560

tacacctaaa atttctaaaa gccctgaacc tacatggaca acaccggctc ccggtaaaac     1620

acaatttatt tctctgaaac ctaaaatccc tctcagccca gaagtgacac acaccaaacc     1680

tgctcccaag cagacaccac gtgctcctcc taagccaaaa acatcaccac gcccaagaat     1740

cccacaaaca caaccagttc ctaaggtgcc ccagcgtgtt actgcaaaac caaaaacgtc     1800

accaagtcca gaagtgtcat acaccacacc tgctccaaaa gatgtgctcc ttcctcataa     1860

accataccct gaggtctctc agagcgaacc tgctcctcta gagacacgag gcatcccttt     1920

tatacccatg atttccccaa gtcctagtca agaggaacta cagaccactc tggaagaaac     1980

agaccaatcc acccaagaac ctttcacaac taagattcca cgaacaactg aactagcaaa     2040

gacaactcag gcgccacaca gattttatac tactgtgagg cccagaacat ctgacaagcc     2100

acacatcaga cctggggtca agcaagcacc caggccatca ggtgctgata gaaatgtatc     2160

agtggactct acccacccca ctaaaaagcc agggactcgc cgcccaccct tgccacccag     2220

acctacacac ccacgaagaa aacctttacc accaaataat gtcactggaa agccaggaag     2280

tgcaggaatc atttcatcag gcccaataac tacaccaccc ctgaggtcaa cacccaggcc     2340

tactggaact cccttggaga gaatagagac agatataaag caaccaacag ttcctgcctc     2400

tggagaagaa ctggaaaata taactgactt tagctcaagc ccaacaagag aaactgatcc     2460

tcttgggaag ccaagattca aaggacctca tgtgcgatac atccaaaagc ctgacaacag     2520

tccctgctcc attactgact ctgtcaaacg gttccccaaa gaggaggcca cagaggggaa     2580

tgccaccagc ccaccacaga acccacccac caacctcact gtggtcaccg tggaagggtg     2640

cccctcattt gtcatcttgg actgggaaaa gccactaaat gacactgtca ctgaatatga     2700

agttatatcc agagaaaatg ggtcattcag tgggaagaac aagtccattc aaatgacaaa     2760

tcagacattt tccacagtag aaaatctgaa accaaacacg agttatgaat tccaggtgaa     2820

acccaaaaac ccgcttggtg aaggcccggt cagcaacaca gtggcattca gtactgaatc     2880

agcggaccca agagtgagtg agccagtttc tgcaggaaga gatgccatct ggactgaaag     2940

accctttaat tcagactctt actcagagtg taagggcaaa caatatgtca aaaggacatg     3000

gtataaaaaa tttgtaggag tgcagctgtg caactctctc agatacaaga tttacttgag     3060

cgactccctc acaggaaaat tttataacat aggtgatcag aggggccatg gagaagatca     3120

ctgccagttt gtggattcat ttttagatgg acgcactggg cagcaactca cttctgacca     3180

gttaccaatc aaagaaggtt atttcagagc agttcgccag gaacctgtcc aatttggaga     3240

aataggtggt cacacccaaa tcaattatgt tcagtggtat gaatgtggga ctacaattcc     3300

tggaaaatgg tagatgctgc acaaagttac cttctgtttc atcattgcaa acaaaaatca     3360

ttgaaaatac tatgccgcat tcatttaaag ctattttgtt tactatgtat aaaagtctac     3420

aatctaatta atagcaatac tagatgttta ttattagaaa agattgctga gagtatttat     3480

caggttttac aaagtcattt taagaaagca agatactgat gttaacagaa taacattttt     3540

ggggaagctg gctccctatt catggtattt taagagatca tttgtatatt atttatcaca     3600

ctgttgtaat gatgttttga gatactttta taacaaaatt aacatcaaaa aggtatatac     3660

tttttaaaaa aaatttactt ttattgatgt gtactcttcc tattgatgag ttaattccat     3720

aaatctctac ttagtttaac ttattggatc aaattatctt cagcatgtat atctggggaa     3780

aaaaggtccg aattttcaca tttatattta aacttcaatt ttttatattt aaacttcaat     3840

tttttagcaa cagctgaata gctttgcgga ggagtttaat agttacacat tcatgctaat     3900

atacatttcc tttaaacatc cacaaattct taaaaagatt gaatcagtaa atttcatttc     3960

agctaaaaat ggagtctaat atattgtttc aaaagataca tttttaccca ccataaatgt     4020

tacaatatct gaatatgctt tgtcaaacta tccctttatg caatcgtctt catattgttt     4080

ttatgattct aatcaagctg tatgtagaga ctgaatgtga agtcaagtct gagcacaaaa     4140

agataatgca cgatgagatt gcctaccatt ttataggata tttactatgt atttatacgt     4200

taagacctct atgaatgaat gtatcagaga atgtctttgt aactgtttaa ttcaatctgt     4260

aataaaaatc taactaacta actcatttat ttctattaaa aaggtattgt cctttaggcg     4320

gggaatggga atccttgctg cactgttgca gtcattctga aaggaccttt ccctgtactt     4380

acctttcaac atgcttcaat cttatcaacg ctacattttg tatttttcaa acaagtataa     4440

attctgcaat aaagagatgt agtttttttt taaaaaaaaa aaaaaaaa                  4488


<210> 5
<211> 189
<212> PRT
<213> Homo sapiens

<400> 5
Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 
        35                  40                  45              


Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala 
    50                  55                  60                  


Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 
65                  70                  75                  80  


Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro 
                85                  90                  95      


Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 
            100                 105                 110         


Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr 
        115                 120                 125             


Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp 
    130                 135                 140                 


Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val 
145                 150                 155                 160 


Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys 
                165                 170                 175     


Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys Leu Ser 
            180                 185                 


<210> 6
<211> 1148
<212> DNA
<213> Homo sapiens

<400> 6
tctctctcgc acacataccc acacacacac acacacacac acacgcgcgc gcgaaaacaa       60

tatctcattt cttcttcagg gagcagctgt gaaggaaatc gggggaggag gatggacaca      120

acatcccatc tttgtgtttc gatacagact aagcttttag gccaaccctc ctgactggat      180

gggggcggcg ggcgtggcat gcatgaaaag taaacatcag agacctgaag aagcttataa      240

aatagcttgg gagaggccag tcaccaagac aggcatctca aatcggctga ttctgcatct      300

ggaaactgcc ttcatcttga aagaaaagct ccaggtccct tctccagcca cccagcccca      360

agatggtgat gctgctgctg ctgctttccg cactggctgg cctcttcggt gcggcagagg      420

gacaagcatt tcatcttggg aagtgcccca atcctccggt gcaggagaat tttgacgtga      480

ataagtatct cggaagatgg tacgaaattg agaagatccc aacaaccttt gagaatggac      540

gctgcatcca ggccaactac tcactaatgg aaaacggaaa gatcaaagtg ttaaaccagg      600

agttgagagc tgatggaact gtgaatcaaa tcgaaggtga agccacccca gttaacctca      660

cagagcctgc caagctggaa gttaagtttt cctggtttat gccatcggca ccgtactgga      720

tcctggccac cgactatgag aactatgccc tcgtgtattc ctgtacctgc atcatccaac      780

tttttcacgt ggattttgct tggatcttgg caagaaaccc taatctccct ccagaaacag      840

tggactctct aaaaaatatc ctgacttcta ataacattga tgtcaagaaa atgacggtca      900

cagaccaggt gaactgcccc aagctctcgt aaccaggttc tacagggagg ctgcacccac      960

tccatgttac ttctgcttcg ctttccccta cccccccccc ataaagacaa accaatcaac     1020

cacgacaaag gaagttgacc tgaacatgta accatgccct accctgttac cttgctagct     1080

gcaaaataaa cttgttgctg acctgctgtg ctcgcagtag attccaagtt aaaaaaaaaa     1140

aaaaaaaa                                                              1148


<210> 7
<211> 402
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Ala Arg Pro Gly Pro Leu Trp Leu Leu Gly Leu Thr Leu Cys 
1               5                   10                  15      


Ala Leu Gly Gly Gly Gly Pro Gly Leu Arg Pro Pro Pro Gly Cys Pro 
            20                  25                  30          


Gln Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Val Gln Arg Glu Ile 
        35                  40                  45              


Leu Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Pro Pro 
    50                  55                  60                  


Ala Ala Ser Arg Leu Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu 
65                  70                  75                  80  


Tyr His Ala Met Ala Gly Asp Asp Asp Glu Asp Gly Ala Pro Ala Glu 
                85                  90                  95      


Gln Arg Leu Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val 
            100                 105                 110         


Glu Arg Asp Arg Ala Leu Gly His Gln Glu Pro His Trp Lys Glu Phe 
        115                 120                 125             


Arg Phe Asp Leu Thr Gln Ile Pro Ala Gly Glu Ala Val Thr Ala Ala 
    130                 135                 140                 


Glu Phe Arg Ile Tyr Lys Val Pro Ser Ile His Leu Leu Asn Arg Thr 
145                 150                 155                 160 


Leu His Val Ser Met Phe Gln Val Val Gln Glu Gln Ser Asn Arg Glu 
                165                 170                 175     


Ser Asp Leu Phe Phe Leu Asp Leu Gln Thr Leu Arg Ala Gly Asp Glu 
            180                 185                 190         


Gly Trp Leu Val Leu Asp Val Thr Ala Ala Ser Asp Cys Trp Leu Leu 
        195                 200                 205             


Lys Arg His Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Thr Glu Asp 
    210                 215                 220                 


Gly His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly Gln Arg Ala 
225                 230                 235                 240 


Pro Arg Ser Gln Gln Pro Phe Val Val Thr Phe Phe Arg Ala Ser Pro 
                245                 250                 255     


Ser Pro Ile Arg Thr Pro Arg Ala Val Arg Pro Leu Arg Arg Arg Gln 
            260                 265                 270         


Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu Pro Gly Ile 
        275                 280                 285             


Phe Asp Asp Val Arg Gly Ser His Gly Arg Gln Val Cys Arg Arg His 
    290                 295                 300                 


Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp Trp Val Ile 
305                 310                 315                 320 


Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu Cys Ser Phe 
                325                 330                 335     


Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala Ile Leu Gln Ser 
            340                 345                 350         


Leu Val His Leu Met Lys Pro Asn Ala Val Pro Lys Ala Cys Cys Ala 
        355                 360                 365             


Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr Asp Ser Ser Asn 
    370                 375                 380                 


Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys Ala Cys Gly 
385                 390                 395                 400 


Cys His 
        


<210> 8
<211> 5642
<212> DNA
<213> Homo sapiens

<400> 8
ggtcgctgcc ggagctcgcc ggtcgcccct gcgctgcgcg gaccgcagcc acagccggac       60

tggtgggaac ggcggcgaca gacggattgg ctgacagtcc cagccctcag aacagccccg      120

gcctcgaagc gttggcgtct gcgtccgcgt cagcgtccgc ttgtcccgga gccggggcag      180

gtgcgcgcgg ggggcgctcc agggaccgcg ctgaggccgc agacgccgcc cgccgagccc      240

cgccccctgc tcgccgaact cagctccccg ttcgccgtcg gggcgtcccc gggcccaggg      300

gcggcggcgg agctgatgtg cgcccgctga gcgcccccgg cccgccatgg ccgcgcgccc      360

cggaccgctc tggcttctgg gcctgacgtt gtgcgcgctg ggcgggggcg gccccggcct      420

gcgacccccg cccggctgtc cccagcgacg tctgggcgcg cgcgagcgcc gggacgtgca      480

gcgcgagatc ctggcggtgc tcgggctacc cgggcggccc cggccccgcg cgccacccgc      540

cgcctcccgg ctgcccgcgt ccgcgccgct cttcatgctg gacctgtacc acgccatggc      600

tggcgacgac gacgaggacg gcgcgcccgc ggagcagcgc ctgggccgcg ccgacctggt      660

catgagcttc gtcaacatgg tggagcgaga ccgtgccctg ggccaccagg agccccattg      720

gaaggagttc cgctttgacc tgacccagat cccggctggg gaggcggtca cagctgcgga      780

gttccggatt tacaaggtgc ccagcatcca cctgctcaac aggaccctcc acgtcagcat      840

gttccaggtg gtccaggagc agtccaacag ggagtctgac ttgttctttt tggatcttca      900

gacgctccga gctggagacg agggctggct ggtgctggat gtcacagcag ccagtgactg      960

ctggttgctg aagcgtcaca aggacctggg actccgcctc tatgtggaga ctgaggacgg     1020

gcacagcgtg gatcctggcc tggccggcct gctgggtcaa cgggccccac gctcccaaca     1080

gcctttcgtg gtcactttct tcagggccag tccgagtccc atccgcaccc ctcgggcagt     1140

gaggccactg aggaggaggc aaccgaagaa aagcaacgag ctgccgcagg ccaaccgact     1200

cccagggatc tttgatgacg tccgcggctc ccacggccgg caggtctgcc gtcggcacga     1260

gctctacgtc agcttccagg accttggctg gctggactgg gtcatcgccc cccaaggcta     1320

ctcagcctat tactgtgagg gggagtgctc cttcccgctg gactcctgca tgaacgccac     1380

caaccacgcc atcctgcagt ccctggtgca cctgatgaag ccaaacgcag tccccaaggc     1440

gtgctgtgca cccaccaagc tgagcgccac ctctgtgctc tactatgaca gcagcaacaa     1500

cgtcatcctg cgcaagcacc gcaacatggt ggtcaaggcc tgcggctgcc actgagtcag     1560

cccgcccagc cctactgcag ccacccttct catctggatc gggccctgca gaggcagaaa     1620

acccttaaat gctgtcacag ctcaagcagg agtgtcaggg gccctcactc tcggtgccta     1680

cttcctgtca ggcttctggt cctttctcgg tacctctgtg cccctcccct ggggtttgtg     1740

gctgtcactc tgcccgacac tttggtggcc taaggcacac agcagcctca gagcctgtgc     1800

tgactgcact gtctggagtc agcacagaag tcctatctta ggacctgtca gactgtggct     1860

ggccccggat ggtctgaggt tggctgaccc gagcttttct ccattcacca gagggtttag     1920

gtgtgaggag aagggctctg cctcttccca ggtacaacac tggccatttc tgggcaaaat     1980

tggacacgct tatgttctca gcacagtgtg ttctgggatt cttctcattt ggtccagggt     2040

gcagttagca tattagaaaa agaataagct ggacatcccc acgaagccac tggggatttt     2100

tttttttttt ttccagatag agtctcactc tgtcacccag gctggagtgc agtggtgcaa     2160

tcctggctca ctgcaacctc tgcctcccag gttcaagcaa ttctcgtgcc tcagcctcct     2220

gagtagctgg gattacaggg gcccaccacc acgcccagct cattcttgta tttttagtag     2280

agacggggtt tcaccatatc ggccaggctg gtcttgaact cctgacctca ggtgatccac     2340

ccgcccggcc tcccaaagtg ttgggatgac aggcatgagc caccgtgcct ggccactggg     2400

gatattttat gtcatgtgta ttcccttgcc ctgggcctgc cccttctcct gcctgggaaa     2460

gaggtatgac tcccacagga gcaaagaatc ctgggggctt ccagttccct ccaccatctc     2520

taccatgctg acccatttgg ggctcagcac tgagacagag gcaagaccag cagctccaac     2580

atgtagtgta ggctggcaca gagcaaatgc ccccgcagcc tgctcccctt gcccatggct     2640

catgtcagta atcaacctac gtacctttcc cactgaacca ggacagggcc tccaggcctc     2700

agcacagaac tgcagacagc caccaccagg cattgtcaat aagacctcag ttccccctcc     2760

tgccccactg cagagcaatc cattccatcc aaagcagggt gactggcagt ctccggccag     2820

gcatggggca agggtgggga ctgccagtgt ttgcttgtgt ctaggagtta tgaacaagct     2880

ggccaccaaa attggcgtca ccctgggtgc ccaccagcgc tgtcctgtgt cttgggtctg     2940

tgagtcaaag aaaaggtccc tgtcccaggg agtgacaggc agtaattagg ctgagttggg     3000

tggggaggtt tgtctcggcc tccactgttc ccggaaaccg ctgttctcct tggaacagcc     3060

actgggagtt ggagtgttta tttgatttct gacttgctaa gcctgtaatt tacctgctgg     3120

aacagacaga gtccagctgc ccaaaccgtg tcattaaaag cagatcctgg gcccgcccca     3180

tccacaggca cagcctggca gagtggttcc acctccccat gggcccaagg atgcgcctct     3240

ctggagttca cgtgctgcac ccccagggag gggcctgggg agagctggtc cagcagcagg     3300

ggtggaggct ggggccacac tgcgggacag cagcccctcc acctggacca gggagggcct     3360

ccatgtgcaa gcgcagagga agagaccctc tcatgtacat aaagggtggg cccaggctgt     3420

ctggaagatg gtgagttccc cactagtcta aggcttcaag ctcagctagc agagattgga     3480

agaggcaatg gcctgagtgt taggagacag gtattctggt tccaactcag ccactgactt     3540

ggtgtcagga caagtcccct ttcttattca cgcttcagtt tctcatctgc aacatgagga     3600

cataggactc tttaattcca aaggctcttc caacccagag aacccatctg cccccatgac     3660

cttctcccag agcttgagac atggcctgag ccccctgctg ccataggact tggggcctat     3720

ctgccattgc aggacctgat ttaacagctc tcttcttcca atactgggca gtagagtttc     3780

ggaaactgac aaatgtgtgg tctcttcagt gcccagtgtg taacctggca tggtttgggt     3840

gtgctaggag tttgtgaaat gaatgttttc aagacgcaaa cgctgctatg cccatcaggt     3900

gtgcacagca ggcctgagga tcatgatgag actccctttt tatgcagcaa agcacaaagt     3960

gtgacagtcg tggccttcct ggtggccaga cttctagcaa ctttagccac ccaccaaatg     4020

acatcacata cagaaggcct cagaaaggga ggaggtcgta aggacacaca gctgatgaag     4080

ggtcagtgct cagctatcaa ggtcatcttc tggcctggtt gcctcccaca gcccaggatg     4140

cattcaaggc tgcacatcag gagcataaat aagggtggtc agctcaggcc cactggctgc     4200

aacaagtagc cactgacagg gagtctgggg ccatttggtg cagaacaacc cccaacccag     4260

tggccatctt cacaactgca gcacagtgct ggccctaatg ccaggtgagc gtgcaaagtc     4320

ctgtttcttt gtctttacat agggaccggg cgatgcgctt tagagaaatt ccctattatt     4380

tcacaggaaa ggaggctgtg aaaaggagag ggcaggtttt ggagccaagt cgacctggca     4440

tcaggtcctg gctgcctttt tttttttttt tttaaagaca tacatggtct tgctttgtcg     4500

cccaggctgg agtgcagtgg cagtgtcatg gctcactgca gcctcaacct gctgggctca     4560

agcaatcctc ccacttcagc ccgagttgct gggatgacag gcacacgcca ccatacccag     4620

ctaattttta aattttttat agaaaccagg tctcactatg ttgcccaggc cggtcttaaa     4680

ctttgcccag gccagtcttg aactcctgag ctcaagcaat cctcctgcct cagcctccca     4740

aagtgctagg attacaggcg tgagccactt acccggcctc tgcctcttgt taatttgacc     4800

acatcatgta cctgctgtgc ccgttccttc ctccgtagaa gagggtgctg gtcctgccct     4860

tttgaggcct ccatgagggc caaatgtgcc atgggacact tagtgccatg cctgcgcaga     4920

cctgtggaat aaacagcaat tctgagcagg ctcattttaa agggacttgc aaatttgggc     4980

gttccttgtg tgccttcctc ataaaaccca ctcctcccag aatatgctta gaggtgctgc     5040

tgtatttacc tgagagctat gcttttcatc aaaaacctaa acgtgatcat ctcttggatg     5100

aggtgtggcc ctgcacactc gcctgctcgt ggaaggagtc tgggccagca gtgacccacg     5160

cgctagggtc tctgctgagg aagtggcagg tgtgcggccc tgccctggcc ccgtagtgag     5220

tgtggggccc acctgtgccc tcatgggcag ctgaaggggg agctttctac cccaggttcc     5280

tttccttact gaaaagtctt gagcaaacag ttgccgctct ccaccccctg ctttttaaaa     5340

aaaatttttt ctcacgtaag aaaatgttat ctgtgtgctg gggaaaattt tgaaaataac     5400

aaaaaccaga atacaaacac ccataatcaa tcacagagat aaccactgtt cataattcct     5460

tccagtcttc ttacttggca catatacatt tgtctttctt tatatatgac atatggatat     5520

tttacaaagt taggatccta ctctatgcac tgcttggtga tcggatctat tcaatgtaca     5580

aaatattttg aaagtttctg tgattaaatg ttctttgaaa acataaaaaa aaaaaaaaaa     5640

aa                                                                    5642


<210> 9
<211> 1663
<212> PRT
<213> Homo sapiens

<400> 9
Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210> 10
<211> 5101
<212> DNA
<213> Homo sapiens

<400> 10
cactcctccc catcctctcc ctctgtccct ctgtccctct gaccctgcac tgtcccagca       60

ccatgggacc cacctcaggt cccagcctgc tgctcctgct actaacccac ctccccctgg      120

ctctggggag tcccatgtac tctatcatca cccccaacat cttgcggctg gagagcgagg      180

agaccatggt gctggaggcc cacgacgcgc aaggggatgt tccagtcact gttactgtcc      240

acgacttccc aggcaaaaaa ctagtgctgt ccagtgagaa gactgtgctg acccctgcca      300

ccaaccacat gggcaacgtc accttcacga tcccagccaa cagggagttc aagtcagaaa      360

aggggcgcaa caagttcgtg accgtgcagg ccaccttcgg gacccaagtg gtggagaagg      420

tggtgctggt cagcctgcag agcgggtacc tcttcatcca gacagacaag accatctaca      480

cccctggctc cacagttctc tatcggatct tcaccgtcaa ccacaagctg ctacccgtgg      540

gccggacggt catggtcaac attgagaacc cggaaggcat cccggtcaag caggactcct      600

tgtcttctca gaaccagctt ggcgtcttgc ccttgtcttg ggacattccg gaactcgtca      660

acatgggcca gtggaagatc cgagcctact atgaaaactc accacagcag gtcttctcca      720

ctgagtttga ggtgaaggag tacgtgctgc ccagtttcga ggtcatagtg gagcctacag      780

agaaattcta ctacatctat aacgagaagg gcctggaggt caccatcacc gccaggttcc      840

tctacgggaa gaaagtggag ggaactgcct ttgtcatctt cgggatccag gatggcgaac      900

agaggatttc cctgcctgaa tccctcaagc gcattccgat tgaggatggc tcgggggagg      960

ttgtgctgag ccggaaggta ctgctggacg gggtgcagaa cccccgagca gaagacctgg     1020

tggggaagtc tttgtacgtg tctgccaccg tcatcttgca ctcaggcagt gacatggtgc     1080

aggcagagcg cagcgggatc cccatcgtga cctctcccta ccagatccac ttcaccaaga     1140

cacccaagta cttcaaacca ggaatgccct ttgacctcat ggtgttcgtg acgaaccctg     1200

atggctctcc agcctaccga gtccccgtgg cagtccaggg cgaggacact gtgcagtctc     1260

taacccaggg agatggcgtg gccaaactca gcatcaacac acaccccagc cagaagccct     1320

tgagcatcac ggtgcgcacg aagaagcagg agctctcgga ggcagagcag gctaccagga     1380

ccatgcaggc tctgccctac agcaccgtgg gcaactccaa caattacctg catctctcag     1440

tgctacgtac agagctcaga cccggggaga ccctcaacgt caacttcctc ctgcgaatgg     1500

accgcgccca cgaggccaag atccgctact acacctacct gatcatgaac aagggcaggc     1560

tgttgaaggc gggacgccag gtgcgagagc ccggccagga cctggtggtg ctgcccctgt     1620

ccatcaccac cgacttcatc ccttccttcc gcctggtggc gtactacacg ctgatcggtg     1680

ccagcggcca gagggaggtg gtggccgact ccgtgtgggt ggacgtcaag gactcctgcg     1740

tgggctcgct ggtggtaaaa agcggccagt cagaagaccg gcagcctgta cctgggcagc     1800

agatgaccct gaagatagag ggtgaccacg gggcccgggt ggtactggtg gccgtggaca     1860

agggcgtgtt cgtgctgaat aagaagaaca aactgacgca gagtaagatc tgggacgtgg     1920

tggagaaggc agacatcggc tgcaccccgg gcagtgggaa ggattacgcc ggtgtcttct     1980

ccgacgcagg gctgaccttc acgagcagca gtggccagca gaccgcccag agggcagaac     2040

ttcagtgccc gcagccagcc gcccgccgac gccgttccgt gcagctcacg gagaagcgaa     2100

tggacaaagt cggcaagtac cccaaggagc tgcgcaagtg ctgcgaggac ggcatgcggg     2160

agaaccccat gaggttctcg tgccagcgcc ggacccgttt catctccctg ggcgaggcgt     2220

gcaagaaggt cttcctggac tgctgcaact acatcacaga gctgcggcgg cagcacgcgc     2280

gggccagcca cctgggcctg gccaggagta acctggatga ggacatcatt gcagaagaga     2340

acatcgtttc ccgaagtgag ttcccagaga gctggctgtg gaacgttgag gacttgaaag     2400

agccaccgaa aaatggaatc tctacgaagc tcatgaatat atttttgaaa gactccatca     2460

ccacgtggga gattctggct gtgagcatgt cggacaagaa agggatctgt gtggcagacc     2520

ccttcgaggt cacagtaatg caggacttct tcatcgacct gcggctaccc tactctgttg     2580

ttcgaaacga gcaggtggaa atccgagccg ttctctacaa ttaccggcag aaccaagagc     2640

tcaaggtgag ggtggaacta ctccacaatc cagccttctg cagcctggcc accaccaaga     2700

ggcgtcacca gcagaccgta accatccccc ccaagtcctc gttgtccgtt ccatatgtca     2760

tcgtgccgct aaagaccggc ctgcaggaag tggaagtcaa ggctgctgtc taccatcatt     2820

tcatcagtga cggtgtcagg aagtccctga aggtcgtgcc ggaaggaatc agaatgaaca     2880

aaactgtggc tgttcgcacc ctggatccag aacgcctggg ccgtgaagga gtgcagaaag     2940

aggacatccc acctgcagac ctcagtgacc aagtcccgga caccgagtct gagaccagaa     3000

ttctcctgca agggacccca gtggcccaga tgacagagga tgccgtcgac gcggaacggc     3060

tgaagcacct cattgtgacc ccctcgggct gcggggaaca gaacatgatc ggcatgacgc     3120

ccacggtcat cgctgtgcat tacctggatg aaacggagca gtgggagaag ttcggcctag     3180

agaagcggca gggggccttg gagctcatca agaaggggta cacccagcag ctggccttca     3240

gacaacccag ctctgccttt gcggccttcg tgaaacgggc acccagcacc tggctgaccg     3300

cctacgtggt caaggtcttc tctctggctg tcaacctcat cgccatcgac tcccaagtcc     3360

tctgcggggc tgttaaatgg ctgatcctgg agaagcagaa gcccgacggg gtcttccagg     3420

aggatgcgcc cgtgatacac caagaaatga ttggtggatt acggaacaac aacgagaaag     3480

acatggccct cacggccttt gttctcatct cgctgcagga ggctaaagat atttgcgagg     3540

agcaggtcaa cagcctgcca ggcagcatca ctaaagcagg agacttcctt gaagccaact     3600

acatgaacct acagagatcc tacactgtgg ccattgctgg ctatgctctg gcccagatgg     3660

gcaggctgaa ggggcctctt cttaacaaat ttctgaccac agccaaagat aagaaccgct     3720

gggaggaccc tggtaagcag ctctacaacg tggaggccac atcctatgcc ctcttggccc     3780

tactgcagct aaaagacttt gactttgtgc ctcccgtcgt gcgttggctc aatgaacaga     3840

gatactacgg tggtggctat ggctctaccc aggccacctt catggtgttc caagccttgg     3900

ctcaatacca aaaggacgcc cctgaccacc aggaactgaa ccttgatgtg tccctccaac     3960

tgcccagccg cagctccaag atcacccacc gtatccactg ggaatctgcc agcctcctgc     4020

gatcagaaga gaccaaggaa aatgagggtt tcacagtcac agctgaagga aaaggccaag     4080

gcaccttgtc ggtggtgaca atgtaccatg ctaaggccaa agatcaactc acctgtaata     4140

aattcgacct caaggtcacc ataaaaccag caccggaaac agaaaagagg cctcaggatg     4200

ccaagaacac tatgatcctt gagatctgta ccaggtaccg gggagaccag gatgccacta     4260

tgtctatatt ggacatatcc atgatgactg gctttgctcc agacacagat gacctgaagc     4320

agctggccaa tggtgttgac agatacatct ccaagtatga gctggacaaa gccttctccg     4380

ataggaacac cctcatcatc tacctggaca aggtctcaca ctctgaggat gactgtctag     4440

ctttcaaagt tcaccaatac tttaatgtag agcttatcca gcctggagca gtcaaggtct     4500

acgcctatta caacctggag gaaagctgta cccggttcta ccatccggaa aaggaggatg     4560

gaaagctgaa caagctctgc cgtgatgaac tgtgccgctg tgctgaggag aattgcttca     4620

tacaaaagtc ggatgacaag gtcaccctgg aagaacggct ggacaaggcc tgtgagccag     4680

gagtggacta tgtgtacaag acccgactgg tcaaggttca gctgtccaat gactttgacg     4740

agtacatcat ggccattgag cagaccatca agtcaggctc ggatgaggtg caggttggac     4800

agcagcgcac gttcatcagc cccatcaagt gcagagaagc cctgaagctg gaggagaaga     4860

aacactacct catgtggggt ctctcctccg atttctgggg agagaagccc aacctcagct     4920

acatcatcgg gaaggacact tgggtggagc actggcccga ggaggacgaa tgccaagacg     4980

aagagaacca gaaacaatgc caggacctcg gcgccttcac cgagagcatg gttgtctttg     5040

ggtgccccaa ctgaccacac ccccattccc ccactccaga taaagcttca gttatatctc     5100

a                                                                     5101


<210> 11
<211> 99
<212> PRT
<213> Homo sapiens

<400> 11
Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210> 12
<211> 760
<212> DNA
<213> Homo sapiens

<400> 12
gaggaaccga gaggctgaga ctaacccaga aacatccaat tctcaaactg aagctcgcac       60

tctcgcctcc agcatgaaag tctctgccgc ccttctgtgc ctgctgctca tagcagccac      120

cttcattccc caagggctcg ctcagccaga tgcaatcaat gccccagtca cctgctgtta      180

taacttcacc aataggaaga tctcagtgca gaggctcgcg agctatagaa gaatcaccag      240

cagcaagtgt cccaaagaag ctgtgatctt caagaccatt gtggccaagg agatctgtgc      300

tgaccccaag cagaagtggg ttcaggattc catggaccac ctggacaagc aaacccaaac      360

tccgaagact tgaacactca ctccacaacc caagaatctg cagctaactt attttcccct      420

agctttcccc agacaccctg ttttatttta ttataatgaa ttttgtttgt tgatgtgaaa      480

cattatgcct taagtaatgt taattcttat ttaagttatt gatgttttaa gtttatcttt      540

catggtacta gtgtttttta gatacagaga cttggggaaa ttgcttttcc tcttgaacca      600

cagttctacc cctgggatgt tttgagggtc tttgcaagaa tcattaatac aaagaatttt      660

ttttaacatt ccaatgcatt gctaaaatat tattgtggaa atgaatattt tgtaactatt      720

acaccaaata aatatatttt tgtacaaaaa aaaaaaaaaa                            760


<210> 13
<211> 1065
<212> PRT
<213> Homo sapiens

<400> 13
Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr 
            20                  25                  30          


Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp 
        35                  40                  45              


Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly 
    50                  55                  60                  


Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe 
65                  70                  75                  80  


Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile 
                85                  90                  95      


Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu 
            100                 105                 110         


Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys 
        115                 120                 125             


Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 
    130                 135                 140                 


Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu 
145                 150                 155                 160 


Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr 
                165                 170                 175     


Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly 
            180                 185                 190         


Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu 
        195                 200                 205             


Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val 
    210                 215                 220                 


Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys 
225                 230                 235                 240 


Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser 
                245                 250                 255     


Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly 
            260                 265                 270         


Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met 
        275                 280                 285             


Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu 
    290                 295                 300                 


Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr 
305                 310                 315                 320 


Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu 
                325                 330                 335     


Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe 
            340                 345                 350         


Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly 
        355                 360                 365             


Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn 
    370                 375                 380                 


Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala 
385                 390                 395                 400 


Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile 
                405                 410                 415     


Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser 
            420                 425                 430         


Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile 
        435                 440                 445             


Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr 
    450                 455                 460                 


Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val 
465                 470                 475                 480 


Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn 
                485                 490                 495     


Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr 
            500                 505                 510         


Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr 
        515                 520                 525             


Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp 
    530                 535                 540                 


Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys 
545                 550                 555                 560 


Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys 
                565                 570                 575     


Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu 
            580                 585                 590         


Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp 
        595                 600                 605             


Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Ser Met Asn 
    610                 615                 620                 


Gly Phe Met Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp 
625                 630                 635                 640 


Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His 
                645                 650                 655     


Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg 
            660                 665                 670         


Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His Met Trp 
        675                 680                 685             


Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu Thr Thr Asp His 
    690                 695                 700                 


Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Arg 
705                 710                 715                 720 


Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile 
                725                 730                 735     


Ala Ala Val Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu 
            740                 745                 750         


Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu 
        755                 760                 765             


Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr 
    770                 775                 780                 


Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala 
785                 790                 795                 800 


Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His Ala Asp Val 
                805                 810                 815     


Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met Ala Thr Arg Pro Tyr 
            820                 825                 830         


Ser Ile His Ala His Gly Val Gln Thr Glu Ser Ser Thr Val Thr Pro 
        835                 840                 845             


Thr Leu Pro Gly Glu Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg 
    850                 855                 860                 


Ser Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr 
865                 870                 875                 880 


Ser Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro 
                885                 890                 895     


Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg 
            900                 905                 910         


Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser 
        915                 920                 925             


Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys 
    930                 935                 940                 


Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala 
945                 950                 955                 960 


Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val 
                965                 970                 975     


Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp 
            980                 985                 990         


Leu His Thr Val His Phe His Gly  His Ser Phe Gln Tyr  Lys His Arg 
        995                 1000                 1005             


Gly Val  Tyr Ser Ser Asp Val  Phe Asp Ile Phe Pro  Gly Thr Tyr 
    1010                 1015                 1020             


Gln Thr  Leu Glu Met Phe Pro  Arg Thr Pro Gly Ile  Trp Leu Leu 
    1025                 1030                 1035             


His Cys  His Val Thr Asp His  Ile His Ala Gly Met  Glu Thr Thr 
    1040                 1045                 1050             


Tyr Thr  Val Leu Gln Asn Glu  Asp Thr Lys Ser Gly  
    1055                 1060                 1065 


<210> 14
<211> 4674
<212> DNA
<213> Homo sapiens

<400> 14
acaccctaat gcctccaaca ataactgttg actttttatt ttcagtcaga gaagcctggc       60

aaccaagaac tgtttttttg gtggtttacg agaacttaac tgaattggaa aatatttgct      120

ttaatgaaac aatttactct tgtgcaacac taaattgtgt caatcaagca aataaggaag      180

aaagtcttat ttataaaatt gcctgctcct gattttactt catttcttct caggctccaa      240

gaaggggaaa aaaatgaaga ttttgatact tggtattttt ctgtttttat gtagtacccc      300

agcctgggcg aaagaaaagc attattacat tggaattatt gaaacgactt gggattatgc      360

ctctgaccat ggggaaaaga aacttatttc tgttgacacg gaacattcca atatctatct      420

tcaaaatggc ccagatagaa ttgggagact atataagaag gccctttatc ttcagtacac      480

agatgaaacc tttaggacaa ctatagaaaa accggtctgg cttgggtttt taggccctat      540

tatcaaagct gaaactggag ataaagttta tgtacactta aaaaaccttg cctctaggcc      600

ctacaccttt cattcacatg gaataactta ctataaggaa catgaggggg ccatctaccc      660

tgataacacc acagattttc aaagagcaga tgacaaagta tatccaggag agcagtatac      720

atacatgttg cttgccactg aagaacaaag tcctggggaa ggagatggca attgtgtgac      780

taggatttac cattcccaca ttgatgctcc aaaagatatt gcctcaggac tcatcggacc      840

tttaataatc tgtaaaaaag attctctaga taaagaaaaa gaaaaacata ttgaccgaga      900

atttgtggtg atgttttctg tggtggatga aaatttcagc tggtacctag aagacaacat      960

taaaacctac tgctcagaac cagagaaagt tgacaaagac aacgaagact tccaggagag     1020

taacagaatg tattctgtga atggatacac ttttggaagt ctcccaggac tctccatgtg     1080

tgctgaagac agagtaaaat ggtacctttt tggtatgggt aatgaagttg atgtgcacgc     1140

agctttcttt cacgggcaag cactgactaa caagaactac cgtattgaca caatcaacct     1200

ctttcctgct accctgtttg atgcttatat ggtggcccag aaccctggag aatggatgct     1260

cagctgtcag aatctaaacc atctgaaagc cggtttgcaa gcctttttcc aggtccagga     1320

gtgtaacaag tcttcatcaa aggataatat ccgtgggaag catgttagac actactacat     1380

tgccgctgag gaaatcatct ggaactatgc tccctctggt atagacatct tcactaaaga     1440

aaacttaaca gcacctggaa gtgactcagc ggtgtttttt gaacaaggta ccacaagaat     1500

tggaggctct tataaaaagc tggtttatcg tgagtacaca gatgcctcct tcacaaatcg     1560

aaaggagaga ggccctgaag aagagcatct tggcatcctg ggtcctgtca tttgggcaga     1620

ggtgggagac accatcagag taaccttcca taacaaagga gcatatcccc tcagtattga     1680

gccgattggg gtgagattca ataagaacaa cgagggcaca tactattccc caaattacaa     1740

cccccagagc agaagtgtgc ctccttcagc ctcccatgtg gcacccacag aaacattcac     1800

ctatgaatgg actgtcccca aagaagtagg acccactaat gcagatcctg tgtgtctagc     1860

taagatgtat tattctgctg tggatcccac taaagatata ttcactgggc ttattgggcc     1920

aatgaaaata tgcaagaaag gaagtttaca tgcaaatggg agacagaaag atgtagacaa     1980

ggaattctat ttgtttccta cagtatttga tgagaatgag agtttactcc tggaagataa     2040

tattagaatg tttacaactg cacctgatca ggtggataag gaagatgaag actttcagga     2100

atctaataaa atgcactcca tgaatggatt catgtatggg aatcagccgg gtctcactat     2160

gtgcaaagga gattcggtcg tgtggtactt attcagcgcc ggaaatgagg ccgatgtaca     2220

tggaatatac ttttcaggaa acacatatct gtggagagga gaacggagag acacagcaaa     2280

cctcttccct caaacaagtc ttacgctcca catgtggcct gacacagagg ggacttttaa     2340

tgttgaatgc cttacaactg atcattacac aggcggcatg aagcaaaaat atactgtgaa     2400

ccaatgcagg cggcagtctg aggattccac cttctacctg ggagagagga catactatat     2460

cgcagcagtg gaggtggaat gggattattc cccacaaagg gagtgggaaa aggagctgca     2520

tcatttacaa gagcagaatg tttcaaatgc atttttagat aagggagagt tttacatagg     2580

ctcaaagtac aagaaagttg tgtatcggca gtatactgat agcacattcc gtgttccagt     2640

ggagagaaaa gctgaagaag aacatctggg aattctaggt ccacaacttc atgcagatgt     2700

tggagacaaa gtcaaaatta tctttaaaaa catggccaca aggccctact caatacatgc     2760

ccatggggta caaacagaga gttctacagt tactccaaca ttaccaggtg aaactctcac     2820

ttacgtatgg aaaatcccag aaagatctgg agctggaaca gaggattctg cttgtattcc     2880

atgggcttat tattcaactg tggatcaagt taaggacctc tacagtggat taattggccc     2940

cctgattgtt tgtcgaagac cttacttgaa agtattcaat cccagaagga aactggaatt     3000

tgcccttctg tttctagttt ttgatgagaa tgaatcttgg tacttagatg acaacatcaa     3060

aacatactct gatcaccccg agaaagtaaa caaagatgat gaggaattca tagaaagcaa     3120

taaaatgcat gctattaatg gaagaatgtt tggaaaccta caaggcctca caatgcacgt     3180

gggagatgaa gtcaactggt atctgatggg aatgggcaat gaaatagact tacacactgt     3240

acattttcac ggccatagct tccaatacaa gcacagggga gtttatagtt ctgatgtctt     3300

tgacattttc cctggaacat accaaaccct agaaatgttt ccaagaacac ctggaatttg     3360

gttactccac tgccatgtga ccgaccacat tcatgctgga atggaaacca cttacaccgt     3420

tctacaaaat gaagacacca aatctggctg aatgaaataa attggtgata agtggaaaaa     3480

agagaaaaac caatgattca taacaatgta tgtgaaagtg taaaatagaa tgttactttg     3540

gaatgactat aaacattaaa agaagactgg aagcatacaa ctttgtacat ttgtggggga     3600

aaactattaa ttttttgcaa atggaaagat caacagacta tataatgata catgactgac     3660

acttgtacac taggtaataa aactgattca tacagtctaa tgatatcacc gctgttaggg     3720

ttttataaaa ctgcatttaa aaaaagatct atgaccagat attctcctgg gtgctcctca     3780

aaggaacact attaaggttc attgaaatgt tttcaatcat tgccttccca ttgatccttc     3840

taacatgctg ttgacatcac acctaatatt cagagggaat gggcaaggta tgagggaagg     3900

aaataaaaaa taaaataaat aaaatagaat gacacaaatt tgagttttgt gaacccctga     3960

acagatggtc ttaaggacgt tatctggaac tggagaaaag cagagttgag agacaattct     4020

atagattaaa tcctggtaag gacaaacatt gccattagaa gaaaagcttc aaaatagacc     4080

tgtggcagat gtcacatgag tagaatttct gcccagcctt aactgcattc agaggataat     4140

atcaatgaac taaacttgaa ctaaaaattt tttaaacaaa aagttataaa tgaagacaca     4200

tggttgtgaa tacaatgatg tatttcttta ttttcacata cactctagct aaaagagcaa     4260

gagtacacat caacaaaaat ggaaacaagg ctttggctga aaaaaacatg catttgacaa     4320

atcatgttaa tagctagaca agaagaaagt tagctttgta aacttctact tcatttgatt     4380

cagagaaaca gagcatgagt tttcttaaaa gtaacaagaa aaggaacaaa aaaaatgagg     4440

tttgaaatct tttaccatgg caaaacatta acatctttct caaaaacata gagaaatctg     4500

gaaaaatcaa gaagataaaa ttctggacca gttagtgaca ttctttcaag catacttgta     4560

aaatgtttcc ttaaagtgtt cttgggatga aaatgattgt catgtctcca acaacagtga     4620

actgatgttg ttccttggaa taaaagtcaa tccccacctt aaaaaaaaaa aaaa           4674


<210> 15
<211> 114
<212> PRT
<213> Homo sapiens

<400> 15
Met Ser Leu Leu Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Ser 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Val Leu Leu Leu Leu Leu Thr Gln Pro Gly 
            20                  25                  30          


Pro Ile Ala Ser Ala Gly Pro Ala Ala Ala Val Leu Arg Glu Leu Arg 
        35                  40                  45              


Cys Val Cys Leu Gln Thr Thr Gln Gly Val His Pro Lys Met Ile Ser 
    50                  55                  60                  


Asn Leu Gln Val Phe Ala Ile Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Glu Ile Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Gly Gly Asn Lys 
            100                 105                 110         


Glu Asn 
        


<210> 16
<211> 2475
<212> DNA
<213> Homo sapiens

<400> 16
gtgcagaagg cacgaggaag ccacagtgct ccggatcctc caatcttcgc tcctccaatc       60

tccgctcctc cacccagttc aggaacccgc gaccgctcgc agcgctctct tgaccactat      120

gagcctcctg tccagccgcg cggcccgtgt ccccggtcct tcgagctcct tgtgcgcgct      180

gttggtgctg ctgctgctgc tgacgcagcc agggcccatc gccagcgctg gtcctgccgc      240

tgctgtgttg agagagctgc gttgcgtttg tttacagacc acgcaaggag ttcatcccaa      300

aatgatcagt aatctgcaag tgttcgccat aggcccacag tgctccaagg tggaagtggt      360

agcctccctg aagaacggga aggaaatttg tcttgatcca gaagcccctt ttctaaagaa      420

agtcatccag aaaattttgg acggtggaaa caaggaaaac tgattaagag aaatgagcac      480

gcatggaaaa gtttcccagt cttcagcaga gaagttttct ggaggtctct gaacccaggg      540

aagacaagaa ggaaagattt tgttgttgtt tgtttatttg tttttccagt agttagcttt      600

cttcctggat tcctcacttt gaagagtgtg aggaaaacct atgtttgccg cttaagcttt      660

cagctcagct aatgaagtgt ttagcatagt acctctgcta tttgctgtta ttttatctgc      720

tatgctattg aagttttggc aattgactat agtgtgagcc aggaatcact ggctgttaat      780

ctttcaaagt gtcttgaatt gtaggtgact attatatttc caagaaatat tccttaagat      840

attaactgag aaggctgtgg atttaatgtg gaaatgatgt ttcataagaa ttctgttgat      900

ggaaatacac tgttatcttc acttttataa gaaataggaa atattttaat gtttcttggg      960

gaatatgtta gagaatttcc ttactcttga ttgtgggata ctatttaatt atttcacttt     1020

agaaagctga gtgtttcaca ccttatctat gtagaatata tttccttatt cagaatttct     1080

aaaagtttaa gttctatgag ggctaatatc ttatcttcct ataattttag acattcttta     1140

tctttttagt atggcaaact gccatcattt acttttaaac tttgatttta tatgctattt     1200

attaagtatt ttattaggag taccataatt ctggtagcta aatatatatt ttagatagat     1260

gaagaagcta gaaaacaggc aaattcctga ctgctagttt atatagaaat gtattctttt     1320

agtttttaaa gtaaaggcaa acttaacaat gacttgtact ctgaaagttt tggaaacgta     1380

ttcaaacaat ttgaatataa atttatcatt tagttataaa aatatatagc gacatcctcg     1440

aggccctagc atttctcctt ggatagggga ccagagagag cttggaatgt taaaaacaaa     1500

acaaaacaaa aaaaaacaag gagaagttgt ccaagggatg tcaatttttt atccctctgt     1560

atgggttaga ttttccaaaa tcataatttg aagaaggcca gcatttatgg tagaatatat     1620

aattatatat aaggtggcca cgctggggca agttccctcc ccactcacag ctttggcccc     1680

tttcacagag tagaacctgg gttagaggat tgcagaagac gagcggcagc ggggagggca     1740

gggaagatgc ctgtcgggtt tttagcacag ttcatttcac tgggattttg aagcatttct     1800

gtctgaatgt aaagcctgtt ctagtcctgg tgggacacac tggggttggg ggtgggggaa     1860

gatgcggtaa tgaaaccggt tagtcagtgt tgtcttaata tccttgataa tgctgtaaag     1920

tttattttta caaatatttc tgtttaagct atttcacctt tgtttggaaa tccttccctt     1980

ttaaagagaa aatgtgacac ttgtgaaaag gcttgtagga aagctcctcc ctttttttct     2040

ttaaaccttt aaatgacaaa cctaggtaat taatggttgt gaatttctat ttttgctttg     2100

tttttaatga acatttgtct ttcagaatag gattctgtga taatatttaa atggcaaaaa     2160

caaaacataa ttttgtgcaa ttaacaaagc tactgcaaga aaaataaaac atttcttggt     2220

aaaaacgtat gtatttatat attatatatt tatatataat atatattata tatttagcat     2280

tgctgagctt tttagatgcc tattgtgtat cttttaaagg ttttgaccat tttgttatga     2340

gtaattacat atatattaca ttcactatat taaaattgta cttttttact atgtgtctca     2400

ttggttcata gtctttattt tgtcctttga ataaacatta aaagatttct aaacttcaaa     2460

aaaaaaaaaa aaaaa                                                      2475


<210> 17
<211> 266
<212> PRT
<213> Homo sapiens

<400> 17
Met Arg Val Thr Leu Ala Thr Ile Ala Trp Met Val Ser Phe Val Ser 
1               5                   10                  15      


Asn Tyr Ser His Thr Ala Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp 
            20                  25                  30          


Phe Ile Lys Asp Cys Val Arg Ile His Asn Lys Phe Arg Ser Glu Val 
        35                  40                  45              


Lys Pro Thr Ala Ser Asp Met Leu Tyr Met Thr Trp Asp Pro Ala Leu 
    50                  55                  60                  


Ala Gln Ile Ala Lys Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn 
65                  70                  75                  80  


Thr Arg Leu Lys Pro Pro His Lys Leu His Pro Asn Phe Thr Ser Leu 
                85                  90                  95      


Gly Glu Asn Ile Trp Thr Gly Ser Val Pro Ile Phe Ser Val Ser Ser 
            100                 105                 110         


Ala Ile Thr Asn Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr 
        115                 120                 125             


Arg Ile Cys Lys Lys Val Cys Gly His Tyr Thr Gln Val Val Trp Ala 
    130                 135                 140                 


Asp Ser Tyr Lys Val Gly Cys Ala Val Gln Phe Cys Pro Lys Val Ser 
145                 150                 155                 160 


Gly Phe Asp Ala Leu Ser Asn Gly Ala His Phe Ile Cys Asn Tyr Gly 
                165                 170                 175     


Pro Gly Gly Asn Tyr Pro Thr Trp Pro Tyr Lys Arg Gly Ala Thr Cys 
            180                 185                 190         


Ser Ala Cys Pro Asn Asn Asp Lys Cys Leu Asp Asn Leu Cys Val Asn 
        195                 200                 205             


Arg Gln Arg Asp Gln Val Lys Arg Tyr Tyr Ser Val Val Tyr Pro Gly 
    210                 215                 220                 


Trp Pro Ile Tyr Pro Arg Asn Arg Tyr Thr Ser Leu Phe Leu Ile Val 
225                 230                 235                 240 


Asn Ser Val Ile Leu Ile Leu Ser Val Ile Ile Thr Ile Leu Val Gln 
                245                 250                 255     


His Lys Tyr Pro Asn Leu Val Leu Leu Asp 
            260                 265     


<210> 18
<211> 3924
<212> DNA
<213> Homo sapiens

<400> 18
agtgatgaac tcatgctctg ttctgttttc tcaaagctga agtcggctag gtttgcaaag       60

ctgtgggctg agcactcagg caatcacact ctcagaaact gcggcggctc tggactgcag      120

cctcccaagg ctccatgcca gacaaagcat gcgtgtcaca cttgctacaa tagcctggat      180

ggtttctttt gtctccaatt attcacacac agcaaatatt ttgccagata tcgaaaatga      240

agatttcatc aaagactgcg ttcgaatcca taacaagttc cgatcagagg tgaaaccaac      300

agccagtgat atgctataca tgacttggga cccagcacta gcccaaattg caaaagcatg      360

ggccagcaat tgccagtttt cacataatac acggctgaag ccaccccaca agctgcaccc      420

aaacttcact tcactgggag agaacatctg gactgggtct gtgcccattt tttctgtgtc      480

ttccgccatc acaaactggt atgacgaaat ccaggactat gacttcaaga ctcggatatg      540

caaaaaagtc tgtggccact acactcaggt tgtttgggca gatagttaca aagttggctg      600

cgcagttcaa ttttgcccta aagtttctgg ctttgacgct ctttccaatg gagcacattt      660

tatatgcaac tacggaccag gagggaatta cccaacttgg ccatataaga gaggagccac      720

ctgcagtgcc tgccccaata atgacaagtg tttggacaat ctctgtgtta accgacagcg      780

agaccaagtc aaacgttact actctgttgt atatccaggc tggcccatat atccacgtaa      840

cagatacact tctctctttc tcattgttaa ttcagtaatt ctaatactgt ctgttataat      900

taccattttg gtacagcaca agtaccctaa tttagttctt ttggactaat acaattcagg      960

aaagaaaaaa cccaaaaacc aacctcattc acatatggct ttttttttaa ccaataacaa     1020

ttaggtgtac ttctatttta aaacatttca gaaaaaaata tatgttatag caatactctt     1080

actcaaaaga agaaatttcc taactctatc agataaactc atctttagta taaataagca     1140

ttatttgcag gttgccacag gtggactttt agtaagtaac ctaacccatg tttcagcttc     1200

taaatctgca aaatgagcaa ggtacagtag cacattttta ggtgattctt agtaactcca     1260

gtagccttca ttagttaaaa acattattat tttttgcatg ctgcttcgac tctaaatatc     1320

tggttttccc tgtctttttg gtttactact tccccagatt cagaacagag gagtaactag     1380

gggatctgat tttagaggcc ttaattttct gttcatggac tgttaaaagt aaaaccaaac     1440

tttcaaaagg gataaaccta aatatttact tgttatcatt agagagggaa catcaaatgc     1500

tgggacatca ttactaacca atagcatcag acactggatt taatggataa tcacaatggt     1560

cgtaatgtat acaaagactt atataccact ttctcgtata aatttttcaa aaaatacaat     1620

aataatataa tttataaaga acactcttct atgaacaacc accaccacca aaaaaaaaaa     1680

aagccctcag aaaatttctc acaaataagg caactaatgc ctgatatctc aaaatccttt     1740

acaaaaggag atagttctag tcaaggagtt ttgggtatgt tacttttttt tcttcttttt     1800

cttttcatct gcctccatct taagtgcaat ttcttcagct gtaagagctc ccagtttctt     1860

attctttgct ttcttaacct tttccttgat gctggccaca tcaattttag tttcagtaga     1920

agctagacaa attaaaagca caacacatgt aatactttag attttaccaa gtaaaacaaa     1980

gaatatatgt ttaacaaaga atatatgttt aaggcagtta acttcagagt attcttataa     2040

ttgaataatt gaaaggtgat cacagtataa aatataaaaa cacttgccta aagcagttag     2100

aaatttcttc agattaagat aaaacaaatc ataaaatact ttatatatta gtacaagtat     2160

acataaaaat ggcataaatg gcataattga accaattact ggattcaact atattaagac     2220

tatttcctta aatcctactt cagactaaat tattttacct acattctttt ccatattttg     2280

gaacttctga gtcattattt tccatcttgc acattaaaat aatttaaaat tacatgtatc     2340

ccttctcaat aagtttaatc agctaaccct aagctagagg tcaaaatcta cttcctctaa     2400

tatcaaaacg aaaatttaaa gttttccaaa tattaattca atattaattg aatattcaat     2460

gaattaattc atttaatgtt agattaattc attgaatatt aattcaatga atgactaatt     2520

aatagtattt taacaagatt ttggtatatt taacaacatt ttggtaataa agacaataat     2580

ttgagagtgt gtggaagtcc ccctaataga agccaactat ctaatcaatg ccaaaagtgt     2640

gaacaaaata gagaaaggaa gcagtgaaaa agaatgcaac tttttcttac cattcaaagt     2700

acaggatcac agcataaaag aatcataaga taaaacatca aactacccag caacctgaga     2760

agcacagagt gttaaagcct ccaccgtgtg gagaaactaa attagggtaa ctagctattg     2820

agtatattga gtaccttcaa agcactcaac tgacaggttt tacagactgg aaattataat     2880

acttatgaca tttctacctt ttatataacc aataatctac catagaatgt agtattttta     2940

aagctattaa caagcaatat attaaaataa taatgtatta tatctgtttc tgacccagtc     3000

tatgtacaat attgctggtg agccctctcc cttcagtgtg tcactgttca ctttggaggg     3060

ttactttagg aagaggataa gtgttaccac aggggaaaaa aatgcagaag aggatgcatc     3120

agaagaaatg gcatgacaat gttttctctt agtgtctttt aaatactagg ttagtgcgaa     3180

agtgatttct gccatttaaa aaccacaatc actttcgcac taatagctcc tgaataagac     3240

ctgtcagcat cctttagtct aaggtgatga gaaatccatg ttaccgatat agaagccaaa     3300

ctctaagcca agatcacata aagagaagaa aaagtacaac ttctgataat tcctctttga     3360

gaggcatgac agcagagctc agggatcttc ttgcatttct acagaagatg cactggctgc     3420

cctgggtttg tatctttcac aacaaagagt cttttccaag cacagaccag aggtcaggag     3480

aggactgtca atccagtttg cactgaaata ggcattagct gcctctaaat tataaattat     3540

ctcagccatc ccttgtcctt aggattagta attaatgaaa tgctaagaga actgatgaaa     3600

agatacaact gtttcttaaa aagattcaga caaatttatt atgggtttac ttttcctaat     3660

taataaagac ttttacatca tagaaagcat taccttcctt aggtttcaca attggttttt     3720

ccttaggtgg aataaatgct ttgtttcttt cctcttgtct cttactgatg gcttctgctt     3780

gtttagccta cattaataaa taaaaaatat atcagttaaa tgtatttata gttaaataat     3840

tcaagtatct atgaactttg ctattcatgt gagccagaca taaagtgccg tacctttatt     3900

gcttccaaaa aaaaaaaaaa aaaa                                            3924


<210> 19
<211> 297
<212> PRT
<213> Homo sapiens

<400> 19
Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Glu Pro Pro Ala Pro Gly Asn Ala Ser 
    130                 135                 140                 


Glu Ser Glu Glu Asp Arg Ser Ala Gly Ser Val Glu Ser Pro Ser Val 
145                 150                 155                 160 


Ser Ser Thr His Arg Val Ser Asp Pro Lys Phe His Pro Leu His Ser 
                165                 170                 175     


Lys Ile Ile Ile Ile Lys Lys Gly His Ala Lys Asp Ser Gln Arg Tyr 
            180                 185                 190         


Lys Val Asp Tyr Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser 
        195                 200                 205             


Glu Ser Lys Arg Glu Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu 
    210                 215                 220                 


Asp Thr Leu Asn His Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly 
225                 230                 235                 240 


Val His Ile Pro Asn Cys Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln 
                245                 250                 255     


Cys Arg Pro Ser Lys Gly Arg Lys Arg Gly Phe Cys Trp Cys Val Asp 
            260                 265                 270         


Lys Tyr Gly Gln Pro Leu Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp 
        275                 280                 285             


Val His Cys Tyr Ser Met Gln Ser Lys 
    290                 295         


<210> 20
<211> 264
<212> PRT
<213> Homo sapiens

<400> 20
Gly Ala Ser Ser Ala Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys 
1               5                   10                  15      


Asp Ala Arg Ala Leu Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala 
            20                  25                  30          


Glu Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu 
        35                  40                  45              


Ser Glu Gly Gln Pro Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly 
    50                  55                  60                  


Leu Arg Cys Gln Pro Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu 
65                  70                  75                  80  


Leu Asp Gly Arg Gly Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu 
                85                  90                  95      


Arg Ala Tyr Leu Leu Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu 
            100                 105                 110         


Ser Glu Glu Asp Arg Ser Ala Gly Glu Val Glu Ser Pro Ser Val Ser 
        115                 120                 125             


Ser Thr His Arg Val Ser Asp Pro Lys Phe His Pro Leu His Ser Lys 
    130                 135                 140                 


Ile Ile Ile Ile Lys Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys 
145                 150                 155                 160 


Val Asp Tyr Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu 
                165                 170                 175     


Ser Lys Arg Glu Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp 
            180                 185                 190         


Thr Leu Asn His Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val 
        195                 200                 205             


His Ile Pro Asn Cys Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys 
    210                 215                 220                 


Arg Pro Ser Lys Gly Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys 
225                 230                 235                 240 


Tyr Gly Gln Pro Leu Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val 
                245                 250                 255     


His Cys Tyr Ser Met Gln Ser Lys 
            260                 


<210> 21
<211> 2638
<212> DNA
<213> Homo sapiens

<400> 21
agatgcgagc actgcggctg ggcgctgagg atcagccgct tcctgcctgg attccacagc       60

ttcgcgccgt gtactgtcgc cccatccctg cgcgcccagc ctgccaagca gcgtgccccg      120

gttgcaggcg tcatgcagcg ggcgcgaccc acgctctggg ccgctgcgct gactctgctg      180

gtgctgctcc gcgggccgcc ggtggcgcgg gctggcgcga gctcggcggg cttgggtccc      240

gtggtgcgct gcgagccgtg cgacgcgcgt gcactggccc agtgcgcgcc tccgcccgcc      300

gtgtgcgcgg agctggtgcg cgagccgggc tgcggctgct gcctgacgtg cgcactgagc      360

gagggccagc cgtgcggcat ctacaccgag cgctgtggct ccggccttcg ctgccagccg      420

tcgcccgacg aggcgcgacc gctgcaggcg ctgctggacg gccgcgggct ctgcgtcaac      480

gctagtgccg tcagccgcct gcgcgcctac ctgctgccag cgccgccagc tccaggtgag      540

ccgcccgcgc caggaaatgc tagtgagtcg gaggaagacc gcagcgccgg cagtgtggag      600

agcccgtccg tctccagcac gcaccgggtg tctgatccca agttccaccc cctccattca      660

aagataatca tcatcaagaa agggcatgct aaagacagcc agcgctacaa agttgactac      720

gagtctcaga gcacagatac ccagaacttc tcctccgagt ccaagcggga gacagaatat      780

ggtccctgcc gtagagaaat ggaagacaca ctgaatcacc tgaagttcct caatgtgctg      840

agtcccaggg gtgtacacat tcccaactgt gacaagaagg gattttataa gaaaaagcag      900

tgtcgccctt ccaaaggcag gaagcggggc ttctgctggt gtgtggataa gtatgggcag      960

cctctcccag gctacaccac caaggggaag gaggacgtgc actgctacag catgcagagc     1020

aagtagacgc ctgccgcaag gttaatgtgg agctcaaata tgccttattt tgcacaaaag     1080

actgccaagg acatgaccag cagctggcta cagcctcgat ttatatttct gtttgtggtg     1140

aactgatttt ttttaaacca aagtttagaa agaggttttt gaaatgccta tggtttcttt     1200

gaatggtaaa cttgagcatc ttttcacttt ccagtagtca gcaaagagca gtttgaattt     1260

tcttgtcgct tcctatcaaa atattcagag actcgagcac agcacccaga cttcatgcgc     1320

ccgtggaatg ctcaccacat gttggtcgaa gcggccgacc actgactttg tgacttaggc     1380

ggctgtgttg cctatgtaga gaacacgctt cacccccact ccccgtacag tgcgcacagg     1440

ctttatcgag aataggaaaa cctttaaacc ccggtcatcc ggacatccca acgcatgctc     1500

ctggagctca cagccttctg tggtgtcatt tctgaaacaa gggcgtggat ccctcaacca     1560

agaagaatgt ttatgtcttc aagtgacctg tactgcttgg ggactattgg agaaaataag     1620

gtggagtcct acttgtttaa aaaatatgta tctaagaatg ttctagggca ctctgggaac     1680

ctataaaggc aggtatttcg ggccctcctc ttcaggaatc ttcctgaaga catggcccag     1740

tcgaaggccc aggatggctt ttgctgcggc cccgtggggt aggagggaca gagagacagg     1800

gagagtcagc ctccacattc agaggcatca caagtaatgg cacaattctt cggatgactg     1860

cagaaaatag tgttttgtag ttcaacaact caagacgaag cttatttctg aggataagct     1920

ctttaaaggc aaagctttat tttcatctct catcttttgt cctccttagc acaatgtaaa     1980

aaagaatagt aatatcagaa caggaaggag gaatggcttg ctggggagcc catccaggac     2040

actgggagca catagagatt cacccatgtt tgttgaactt agagtcattc tcatgctttt     2100

ctttataatt cacacatata tgcagagaag atatgttctt gttaacattg tatacaacat     2160

agccccaaat atagtaagat ctatactaga taatcctaga tgaaatgtta gagatgctat     2220

atgatacaac tgtggccatg actgaggaaa ggagctcacg cccagagact gggctgctct     2280

cccggaggcc aaacccaaga aggtctggca aagtcaggct cagggagact ctgccctgct     2340

gcagacctcg gtgtggacac acgctgcata gagctctcct tgaaaacaga ggggtctcaa     2400

gacattctgc ctacctatta gcttttcttt atttttttaa ctttttgggg ggaaaagtat     2460

ttttgagaag tttgtcttgc aatgtattta taaatagtaa ataaagtttt taccattaaa     2520

aaaatatctt tccctttgtt attgaccatc tctgggcttt gtatcactaa ttattttatt     2580

ttattatata ataattattt tattataata aaatcctgaa aggggaaaat aaaaaaaa       2638


<210> 22
<211> 240
<212> PRT
<213> Homo sapiens

<400> 22
Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210> 23
<211> 980
<212> DNA
<213> Homo sapiens

<400> 23
gcggcggcgg gcagcagctg cgctgcgact gctctggaag gagaggacgg ggcacaaacc       60

ctgaccatga ccccccacag gctgctgcca ccgctgctgc tgctgctagc tctgctgctc      120

gctgccagcc caggaggcgc cttggcgcgg tgcccaggct gcgggcaagg ggtgcaggcg      180

ggttgtccag ggggctgcgt ggaggaggag gatggggggt cgccagccga gggctgcgcg      240

gaagctgagg gctgtctcag gagggagggg caggagtgcg gggtctacac ccctaactgc      300

gccccaggac tgcagtgcca tccgcccaag gacgacgagg cgcctttgcg ggcgctgctg      360

ctcggccgag gccgctgcct tccggcccgc gcgcctgctg ttgcagagga gaatcctaag      420

gagagtaaac cccaagcagg cactgcccgc ccacaggatg tgaaccgcag agaccaacag      480

aggaatccag gcacctctac cacgccctcc cagcccaatt ctgcgggtgt ccaagacact      540

gagatgggcc catgccgtag acatctggac tcagtgctgc agcaactcca gactgaggtc      600

taccgagggg ctcaaacact ctacgtgccc aattgtgacc atcgaggctt ctaccggaag      660

cggcagtgcc gctcctccca ggggcagcgc cgaggtccct gctggtgtgt ggatcggatg      720

ggcaagtccc tgccagggtc tccagatggc aatggaagct cctcctgccc cactgggagt      780

agcggctaaa gctgggggat agaggggctg cagggccact ggaaggaaca tggagctgtc      840

atcactcaac aaaaaaccga ggccctcaat ccaccttcag gccccgcccc atgggcccct      900

caccgctggt tggaaagagt gttggtgttg gctggggtgt caataaagct gtgcttgggg      960

tcgctgaaaa aaaaaaaaaa                                                  980


<210> 24
<211> 271
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              


Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  


Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  


Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      


Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         


Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     


<210> 25
<211> 159
<212> PRT
<213> Homo sapiens

<400> 25
Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
1               5                   10                  15      


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
            20                  25                  30          


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
        35                  40                  45              


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
    50                  55                  60                  


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
65                  70                  75                  80  


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
                85                  90                  95      


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
            100                 105                 110         


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
        115                 120                 125             


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
    130                 135                 140                 


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
145                 150                 155                 


<210> 26
<211> 2943
<212> DNA
<213> Homo sapiens

<400> 26
accaggcaac accattgaag gctcatatgt aaaaatccat gccttccttt ctcccaatct       60

ccattcccaa acttagccac tggcttctgg ctgaggcctt acgcatacct cccggggctt      120

gcacacacct tcttctacag aagacacacc ttgggcatat cctacagaag accaggcttc      180

tctctggtcc ttggtagagg gctactttac tgtaacaggg ccagggtgga gagttctctc      240

ctgaagctcc atcccctcta taggaaatgt gttgacaata ttcagaagag taagaggatc      300

aagacttctt tgtgctcaaa taccactgtt ctcttctcta ccctgcccta accaggagct      360

tgtcacccca aactctgagg tgatttatgc cttaatcaag caaacttccc tcttcagaaa      420

agatggctca ttttccctca aaagttgcca ggagctgcca agtattctgc caattcaccc      480

tggagcacaa tcaacaaatt cagccagaac acaactacag ctactattag aactattatt      540

attaataaat tcctctccaa atctagcccc ttgacttcgg atttcacgat ttctcccttc      600

ctcctagaaa cttgataagt ttcccgcgct tccctttttc taagactaca tgtttgtcat      660

cttataaagc aaaggggtga ataaatgaac caaatcaata acttctggaa tatctgcaaa      720

caacaataat atcagctatg ccatctttca ctattttagc cagtatcgag ttgaatgaac      780

atagaaaaat acaaaactga attcttccct gtaaattccc cgttttgacg acgcacttgt      840

agccacgtag ccacgcctac ttaagacaat tacaaaaggc gaagaagact gactcaggct      900

taagctgcca gccagagagg gagtcatttc attggcgttt gagtcagcaa agaagtcaag      960

atggccaaag ttccagacat gtttgaagac ctgaagaact gttacagtga aaatgaagaa     1020

gacagttcct ccattgatca tctgtctctg aatcagaaat ccttctatca tgtaagctat     1080

ggcccactcc atgaaggctg catggatcaa tctgtgtctc tgagtatctc tgaaacctct     1140

aaaacatcca agcttacctt caaggagagc atggtggtag tagcaaccaa cgggaaggtt     1200

ctgaagaaga gacggttgag tttaagccaa tccatcactg atgatgacct ggaggccatc     1260

gccaatgact cagaggaaga aatcatcaag cctaggtcag caccttttag cttcctgagc     1320

aatgtgaaat acaactttat gaggatcatc aaatacgaat tcatcctgaa tgacgccctc     1380

aatcaaagta taattcgagc caatgatcag tacctcacgg ctgctgcatt acataatctg     1440

gatgaagcag tgaaatttga catgggtgct tataagtcat caaaggatga tgctaaaatt     1500

accgtgattc taagaatctc aaaaactcaa ttgtatgtga ctgcccaaga tgaagaccaa     1560

ccagtgctgc tgaaggagat gcctgagata cccaaaacca tcacaggtag tgagaccaac     1620

ctcctcttct tctgggaaac tcacggcact aagaactatt tcacatcagt tgcccatcca     1680

aacttgttta ttgccacaaa gcaagactac tgggtgtgct tggcaggggg gccaccctct     1740

atcactgact ttcagatact ggaaaaccag gcgtaggtct ggagtctcac ttgtctcact     1800

tgtgcagtgt tgacagttca tatgtaccat gtacatgaag aagctaaatc ctttactgtt     1860

agtcatttgc tgagcatgta ctgagccttg taattctaaa tgaatgttta cactctttgt     1920

aagagtggaa ccaacactaa catataatgt tgttatttaa agaacaccct atattttgca     1980

tagtaccaat cattttaatt attattcttc ataacaattt taggaggacc agagctactg     2040

actatggcta ccaaaaagac tctacccata ttacagatgg gcaaattaag gcataagaaa     2100

actaagaaat atgcacaata gcagttgaaa caagaagcca cagacctagg atttcatgat     2160

ttcatttcaa ctgtttgcct tctactttta agttgctgat gaactcttaa tcaaatagca     2220

taagtttctg ggacctcagt tttatcattt tcaaaatgga gggaataata cctaagcctt     2280

cctgccgcaa cagtttttta tgctaatcag ggaggtcatt ttggtaaaat acttcttgaa     2340

gccgagcctc aagatgaagg caaagcacga aatgttattt tttaattatt atttatatat     2400

gtatttataa atatatttaa gataattata atatactata tttatgggaa ccccttcatc     2460

ctctgagtgt gaccaggcat cctccacaat agcagacagt gttttctggg ataagtaagt     2520

ttgatttcat taatacaggg cattttggtc caagttgtgc ttatcccata gccaggaaac     2580

tctgcattct agtacttggg agacctgtaa tcatataata aatgtacatt aattaccttg     2640

agccagtaat tggtccgatc tttgactctt ttgccattaa acttacctgg gcattcttgt     2700

ttcaattcca cctgcaatca agtcctacaa gctaaaatta gatgaactca actttgacaa     2760

ccatgagacc actgttatca aaactttctt ttctggaatg taatcaatgt ttcttctagg     2820

ttctaaaaat tgtgatcaga ccataatgtt acattattat caacaatagt gattgataga     2880

gtgttatcag tcataactaa ataaagcttg caacaaaatt ctctgacaaa aaaaaaaaaa     2940

aaa                                                                   2943


<210> 27
<211> 135
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210> 28
<211> 586
<212> DNA
<213> Homo sapiens

<400> 28
agttaaaagg gtgggagcgt ccgggggccc atctctctcg ggtggagtct tctgacagct       60

ggtgcgcctg cccgggaaca tcctcctgga ctcaatcatg gcttgtggtc tggtcgccag      120

caacctgaat ctcaaacctg gagagtgcct tcgagtgcga ggcgaggtgg ctcctgacgc      180

taagagcttc gtgctgaacc tgggcaaaga cagcaacaac ctgtgcctgc acttcaaccc      240

tcgcttcaac gcccacggcg acgccaacac catcgtgtgc aacagcaagg acggcggggc      300

ctgggggacc gagcagcggg aggctgtctt tcccttccag cctggaagtg ttgcagaggt      360

gtgcatcacc ttcgaccagg ccaacctgac cgtcaagctg ccagatggat acgaattcaa      420

gttccccaac cgcctcaacc tggaggccat caactacatg gcagctgacg gtgacttcaa      480

gatcaaatgt gtggcctttg actgaaatca gccagcccat ggcccccaat aaaggcagct      540

gcctctgctc cctctgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                     586


<210> 29
<211> 1721
<212> PRT
<213> Homo sapiens

<400> 29
Met Ala Gly Ala Trp Leu Arg Trp Gly Leu Leu Leu Trp Ala Gly Leu 
1               5                   10                  15      


Leu Ala Ser Ser Ala His Gly Arg Leu Arg Arg Ile Thr Tyr Val Val 
            20                  25                  30          


His Pro Gly Pro Gly Leu Ala Ala Gly Ala Leu Pro Leu Ser Gly Pro 
        35                  40                  45              


Pro Arg Ser Arg Thr Phe Asn Val Ala Leu Asn Ala Arg Tyr Ser Arg 
    50                  55                  60                  


Ser Ser Ala Ala Ala Gly Ala Pro Ser Arg Ala Ser Pro Gly Val Pro 
65                  70                  75                  80  


Ser Glu Arg Thr Arg Arg Thr Ser Lys Pro Gly Gly Ala Ala Leu Gln 
                85                  90                  95      


Gly Leu Arg Pro Pro Pro Pro Pro Pro Pro Glu Pro Ala Arg Pro Ala 
            100                 105                 110         


Val Pro Gly Gly Gln Leu His Pro Asn Pro Gly Gly His Pro Ala Ala 
        115                 120                 125             


Ala Pro Phe Thr Lys Gln Gly Arg Gln Val Val Arg Ser Lys Val Pro 
    130                 135                 140                 


Gln Glu Thr Gln Ser Gly Gly Gly Ser Arg Leu Gln Val His Gln Lys 
145                 150                 155                 160 


Gln Gln Leu Gln Gly Val Asn Val Cys Gly Gly Arg Cys Cys His Gly 
                165                 170                 175     


Trp Ser Lys Ala Pro Gly Ser Gln Arg Cys Thr Lys Pro Ser Cys Val 
            180                 185                 190         


Pro Pro Cys Gln Asn Gly Gly Met Cys Leu Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Lys Pro Gly Thr Lys Gly Lys Ala Cys Glu Thr Ile Ala Ala Gln 
    210                 215                 220                 


Asp Thr Ser Ser Pro Val Phe Gly Gly Gln Ser Pro Gly Ala Ala Ser 
225                 230                 235                 240 


Ser Trp Gly Pro Pro Glu Gln Ala Ala Lys His Thr Ser Ser Lys Lys 
                245                 250                 255     


Ala Asp Thr Leu Pro Arg Val Ser Pro Val Ala Gln Met Thr Leu Thr 
            260                 265                 270         


Leu Lys Pro Lys Pro Ser Val Gly Leu Pro Gln Gln Ile His Ser Gln 
        275                 280                 285             


Val Thr Pro Leu Ser Ser Gln Ser Val Val Ile His His Gly Gln Thr 
    290                 295                 300                 


Gln Glu Tyr Val Leu Lys Pro Lys Tyr Phe Pro Ala Gln Lys Gly Ile 
305                 310                 315                 320 


Ser Gly Glu Gln Ser Thr Glu Gly Ser Phe Pro Leu Arg Tyr Val Gln 
                325                 330                 335     


Asp Gln Val Ala Ala Pro Phe Gln Leu Ser Asn His Thr Gly Arg Ile 
            340                 345                 350         


Lys Val Val Phe Thr Pro Ser Ile Cys Lys Val Thr Cys Thr Lys Gly 
        355                 360                 365             


Ser Cys Gln Asn Ser Cys Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser 
    370                 375                 380                 


Glu Asn Gly His Ala Ala Asp Thr Leu Thr Ala Thr Asn Phe Arg Val 
385                 390                 395                 400 


Val Ile Cys His Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg 
                405                 410                 415     


Asp Lys Cys Gln Cys Pro Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile 
            420                 425                 430         


Pro Val His Gly Ala Ser Val Pro Lys Leu Tyr Gln His Ser Gln Gln 
        435                 440                 445             


Pro Gly Lys Ala Leu Gly Thr His Val Ile His Ser Thr His Thr Leu 
    450                 455                 460                 


Pro Leu Thr Val Thr Ser Gln Gln Gly Val Lys Val Lys Phe Pro Pro 
465                 470                 475                 480 


Asn Ile Val Asn Ile His Val Lys His Pro Pro Glu Ala Ser Val Gln 
                485                 490                 495     


Ile His Gln Val Ser Arg Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys 
            500                 505                 510         


Glu Ala Gln Pro Gly Gln Ser Gln Val Ser Tyr Gln Gly Leu Pro Val 
        515                 520                 525             


Gln Lys Thr Gln Thr Ile His Ser Thr Tyr Ser His Gln Gln Val Ile 
    530                 535                 540                 


Pro His Val Tyr Pro Val Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe 
545                 550                 555                 560 


Gln Glu Thr Ile Gly Ser Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser 
                565                 570                 575     


Lys Gln Glu Asp Cys Cys Gly Thr Val Gly Thr Ser Trp Gly Phe Asn 
            580                 585                 590         


Lys Cys Gln Lys Cys Pro Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln 
        595                 600                 605             


Met Met Glu Cys Leu Pro Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys 
    610                 615                 620                 


Gln Asp Ile Asn Glu Cys Gln Leu Gln Gly Val Cys Pro Asn Gly Glu 
625                 630                 635                 640 


Cys Leu Asn Thr Met Gly Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe 
                645                 650                 655     


Gly Pro Asp Pro Thr Phe Ser Ser Cys Val Pro Asp Pro Pro Val Ile 
            660                 665                 670         


Ser Glu Glu Lys Gly Pro Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln 
        675                 680                 685             


Cys Met His Pro Leu Ser Val His Leu Thr Lys Gln Leu Cys Cys Cys 
    690                 695                 700                 


Ser Val Gly Lys Ala Trp Gly Pro His Cys Glu Lys Cys Pro Leu Pro 
705                 710                 715                 720 


Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr 
                725                 730                 735     


Val Ser Gly Val His Arg Arg Arg Pro Ile His His His Val Gly Lys 
            740                 745                 750         


Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln Pro Val Ala Lys Ser 
        755                 760                 765             


Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu Pro Val Glu Ala Leu 
    770                 775                 780                 


Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala Glu Pro Glu Val Ala 
785                 790                 795                 800 


Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr 
                805                 810                 815     


Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile 
            820                 825                 830         


His Leu His Pro Gln Phe Pro Val Val Ile Glu Lys Thr Ser Pro Pro 
        835                 840                 845             


Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln 
    850                 855                 860                 


Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn Glu Cys Thr Val Asn 
865                 870                 875                 880 


Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn Leu Pro Val Arg Tyr 
                885                 890                 895     


Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys 
            900                 905                 910         


Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln His Leu Cys Ser Gln 
        915                 920                 925             


Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala 
    930                 935                 940                 


Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys Ile Asp Val Asp Glu 
945                 950                 955                 960 


Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His Cys Val Asn Thr Val 
                965                 970                 975     


Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln 
            980                 985                 990         


Arg Gly Arg Cys Glu Asp Ile Asp  Glu Cys Leu Asn Pro  Ser Thr Cys 
        995                 1000                 1005             


Pro Asp  Glu Gln Cys Val Asn  Ser Pro Gly Ser Tyr  Gln Cys Val 
    1010                 1015                 1020             


Pro Cys  Thr Glu Gly Phe Arg  Gly Trp Asn Gly Gln  Cys Leu Asp 
    1025                 1030                 1035             


Val Asp  Glu Cys Leu Glu Pro  Asn Val Cys Ala Asn  Gly Asp Cys 
    1040                 1045                 1050             


Ser Asn  Leu Glu Gly Ser Tyr  Met Cys Ser Cys His  Lys Gly Tyr 
    1055                 1060                 1065             


Thr Arg  Thr Pro Asp His Lys  His Cys Arg Asp Ile  Asp Glu Cys 
    1070                 1075                 1080             


Gln Gln  Gly Asn Leu Cys Val  Asn Gly Gln Cys Lys  Asn Thr Glu 
    1085                 1090                 1095             


Gly Ser  Phe Arg Cys Thr Cys  Gly Gln Gly Tyr Gln  Leu Ser Ala 
    1100                 1105                 1110             


Ala Lys  Asp Gln Cys Glu Asp  Ile Asp Glu Cys Gln  His Arg His 
    1115                 1120                 1125             


Leu Cys  Ala His Gly Gln Cys  Arg Asn Thr Glu Gly  Ser Phe Gln 
    1130                 1135                 1140             


Cys Val  Cys Asp Gln Gly Tyr  Arg Ala Ser Gly Leu  Gly Asp His 
    1145                 1150                 1155             


Cys Glu  Asp Ile Asn Glu Cys  Leu Glu Asp Lys Ser  Val Cys Gln 
    1160                 1165                 1170             


Arg Gly  Asp Cys Ile Asn Thr  Ala Gly Ser Tyr Asp  Cys Thr Cys 
    1175                 1180                 1185             


Pro Asp  Gly Phe Gln Leu Asp  Asp Asn Lys Thr Cys  Gln Asp Ile 
    1190                 1195                 1200             


Asn Glu  Cys Glu His Pro Gly  Leu Cys Gly Pro Gln  Gly Glu Cys 
    1205                 1210                 1215             


Leu Asn  Thr Glu Gly Ser Phe  His Cys Val Cys Gln  Gln Gly Phe 
    1220                 1225                 1230             


Ser Ile  Ser Ala Asp Gly Arg  Thr Cys Glu Asp Ile  Asp Glu Cys 
    1235                 1240                 1245             


Val Asn  Asn Thr Val Cys Asp  Ser His Gly Phe Cys  Asp Asn Thr 
    1250                 1255                 1260             


Ala Gly  Ser Phe Arg Cys Leu  Cys Tyr Gln Gly Phe  Gln Ala Pro 
    1265                 1270                 1275             


Gln Asp  Gly Gln Gly Cys Val  Asp Val Asn Glu Cys  Glu Leu Leu 
    1280                 1285                 1290             


Ser Gly  Val Cys Gly Glu Ala  Phe Cys Glu Asn Val  Glu Gly Ser 
    1295                 1300                 1305             


Phe Leu  Cys Val Cys Ala Asp  Glu Asn Gln Glu Tyr  Ser Pro Met 
    1310                 1315                 1320             


Thr Gly  Gln Cys Arg Ser Arg  Thr Ser Thr Asp Leu  Asp Val Asp 
    1325                 1330                 1335             


Val Asp  Gln Pro Lys Glu Glu  Lys Lys Glu Cys Tyr  Tyr Asn Leu 
    1340                 1345                 1350             


Asn Asp  Ala Ser Leu Cys Asp  Asn Val Leu Ala Pro  Asn Val Thr 
    1355                 1360                 1365             


Lys Gln  Glu Cys Cys Cys Thr  Ser Gly Ala Gly Trp  Gly Asp Asn 
    1370                 1375                 1380             


Cys Glu  Ile Phe Pro Cys Pro  Val Leu Gly Thr Ala  Glu Phe Thr 
    1385                 1390                 1395             


Glu Met  Cys Pro Lys Gly Lys  Gly Phe Val Pro Ala  Gly Glu Ser 
    1400                 1405                 1410             


Ser Ser  Glu Ala Gly Gly Glu  Asn Tyr Lys Asp Ala  Asp Glu Cys 
    1415                 1420                 1425             


Leu Leu  Phe Gly Gln Glu Ile  Cys Lys Asn Gly Phe  Cys Leu Asn 
    1430                 1435                 1440             


Thr Arg  Pro Gly Tyr Glu Cys  Tyr Cys Lys Gln Gly  Thr Tyr Tyr 
    1445                 1450                 1455             


Asp Pro  Val Lys Leu Gln Cys  Phe Asp Met Asp Glu  Cys Gln Asp 
    1460                 1465                 1470             


Pro Ser  Ser Cys Ile Asp Gly  Gln Cys Val Asn Thr  Glu Gly Ser 
    1475                 1480                 1485             


Tyr Asn  Cys Phe Cys Thr His  Pro Met Val Leu Asp  Ala Ser Glu 
    1490                 1495                 1500             


Lys Arg  Cys Ile Arg Pro Ala  Glu Ser Asn Glu Gln  Ile Glu Glu 
    1505                 1510                 1515             


Thr Asp  Val Tyr Gln Asp Leu  Cys Trp Glu His Leu  Ser Asp Glu 
    1520                 1525                 1530             


Tyr Val  Cys Ser Arg Pro Leu  Val Gly Lys Gln Thr  Thr Tyr Thr 
    1535                 1540                 1545             


Glu Cys  Cys Cys Leu Tyr Gly  Glu Ala Trp Gly Met  Gln Cys Ala 
    1550                 1555                 1560             


Leu Cys  Pro Leu Lys Asp Ser  Asp Asp Tyr Ala Gln  Leu Cys Asn 
    1565                 1570                 1575             


Ile Pro  Val Thr Gly Arg Arg  Gln Pro Tyr Gly Arg  Asp Ala Leu 
    1580                 1585                 1590             


Val Asp  Phe Ser Glu Gln Tyr  Thr Pro Glu Ala Asp  Pro Tyr Phe 
    1595                 1600                 1605             


Ile Gln  Asp Arg Phe Leu Asn  Ser Phe Glu Glu Leu  Gln Ala Glu 
    1610                 1615                 1620             


Glu Cys  Gly Ile Leu Asn Gly  Cys Glu Asn Gly Arg  Cys Val Arg 
    1625                 1630                 1635             


Val Gln  Glu Gly Tyr Thr Cys  Asp Cys Phe Asp Gly  Tyr His Leu 
    1640                 1645                 1650             


Asp Thr  Ala Lys Met Thr Cys  Val Asp Val Asn Glu  Cys Asp Glu 
    1655                 1660                 1665             


Leu Asn  Asn Arg Met Ser Leu  Cys Lys Asn Ala Lys  Cys Ile Asn 
    1670                 1675                 1680             


Thr Asp  Gly Ser Tyr Lys Cys  Leu Cys Leu Pro Gly  Tyr Val Pro 
    1685                 1690                 1695             


Ser Asp  Lys Pro Asn Tyr Cys  Thr Pro Leu Asn Thr  Ala Leu Asn 
    1700                 1705                 1710             


Leu Glu  Lys Asp Ser Asp Leu  Glu 
    1715                 1720     


<210> 30
<211> 6168
<212> DNA
<213> Homo sapiens

<400> 30
ggtcgcgccc gctggggccc gcgatggcgg gggcctggct caggtggggg ctcctgctct       60

gggcagggct cctcgcgtcc tcggcgcacg gccggctgcg gaggatcacc tacgtggtgc      120

acccgggccc cggcctggca gccggcgcct tgcccctgag cgggcccccg cgttcgcgga      180

cattcaacgt cgcgctcaac gccaggtaca gccgcagctc ggcggctgcc ggcgccccca      240

gccgtgcctc ccccggggtc ccctcggaga ggacccggcg cacgagcaag ccgggcggcg      300

cggccctgca ggggctcaga ccgccgccgc cgccgccgcc ggagcctgcg cgtcccgcgg      360

tccccggcgg gcagctccac cccaatcccg gcggccaccc ggcagccgcc ccgttcacca      420

aacaaggcag gcaagttgtg cgctccaagg tgccgcagga gacccagagc ggcggaggct      480

ctaggctgca ggttcaccag aagcagcagc tgcagggggt caatgtctgt ggagggcggt      540

gctgtcatgg ctggagtaag gcccctggct cccagaggtg caccaaacct agctgtgttc      600

cgccatgtca gaatggaggg atgtgtctcc ggccacaact ctgtgtgtgt aaaccaggga      660

ccaagggcaa agcctgtgaa acaatagctg cccaggacac ctcgtcacca gtctttggag      720

ggcagagtcc tggggctgct tcctcgtggg gccctcctga gcaagcagca aagcatactt      780

catctaagaa ggcagacact ctaccaagag tcagccctgt ggcccagatg accttaaccc      840

tcaagccgaa gccttcagtg ggactccccc agcagataca ttctcaagtg actcctcttt      900

cttcccagag tgtggtgatt caccatggcc agacccagga atacgtgctc aagcccaagt      960

actttccagc ccagaagggg atttcaggag agcagtccac tgaaggttct ttccctttaa     1020

gatatgtgca ggatcaagtt gcggcacctt ttcagctgag taaccacact ggccgcatca     1080

aggtggtctt tactccgagc atctgtaaag tgacctgcac caagggcagc tgtcagaaca     1140

gctgtgagaa ggggaacacc accactctca ttagtgagaa tggtcatgct gccgacaccc     1200

tgacggccac gaacttccga gtggtaattt gccatcttcc atgtatgaat ggtggccagt     1260

gcagttcaag ggacaaatgt cagtgccctc caaatttcac aggaaaactt tgtcagatcc     1320

cagtccatgg tgccagcgtg cctaaacttt atcagcattc ccagcagcca ggcaaggcgt     1380

tggggacgca tgtcatccat tcaacacata ccttgcctct gaccgtgact agccagcaag     1440

gagtcaaagt gaaatttcct cctaacatag tcaatatcca tgtgaaacat cctcctgaag     1500

cttccgtcca gatacatcag gtttcaagaa ttgatggccc aacaggccag aagacaaaag     1560

aagctcaacc aggccaatcc caagtctcgt accaagggct tcctgtccag aagacccaga     1620

ccatacattc cacatactcc caccagcagg tcattcctca cgtctacccc gtggctgcta     1680

agacacagct tggccggtgc ttccaggaaa ccattgggtc acagtgtggc aaagcgctcc     1740

ctggcctttc aaagcaagag gactgctgtg gaactgtggg tacctcctgg ggctttaaca     1800

aatgccagaa atgccccaag aaaccatctt atcatggata caaccaaatg atggaatgcc     1860

taccgggtta taagcgggtt aacaacacct tttgccaaga tattaatgaa tgtcagctac     1920

aaggtgtatg ccctaatggt gagtgtttga ataccatggg cagctatcga tgtacctgca     1980

aaataggatt tgggccggat cctacctttt caagttgtgt tcctgatccc cctgtgatct     2040

cggaagagaa agggccctgt taccgacttg tcagttctgg aagacagtgt atgcaccctc     2100

tgtctgttca cctcaccaag cagctctgct gttgtagtgt gggcaaggcc tggggcccac     2160

actgtgagaa atgtcccctt ccaggcacag ctgcttttaa ggaaatctgt cctggtggaa     2220

tgggttatac ggtttctggc gttcatagac gcaggccaat ccatcaccat gtaggtaaag     2280

gacctgtatt tgtcaagcca aagaacactc aacctgttgc taaaagtact catcctccac     2340

ctctcccagc caaggaagag ccagtggagg ccctgacctt ctcccgggaa cacgggccag     2400

gagtggcgga gccagaagtg gcaactgcac cccctgaaaa ggaaatacct tcattggatc     2460

aagagaaaac caaacttgag cctggtcaac cccagctgtc tccaggcatt tccactattc     2520

atctgcatcc acagtttcca gtagtgattg aaaaaacatc acctcctgtg cctgttgaag     2580

tagctcctga agcttctacg tctagtgcca gccaagtgat tgctcctact caagtgacag     2640

aaatcaatga atgtactgtg aaccctgata tctgtggagc aggacactgc attaacctac     2700

cagtgagata tacctgtata tgctacgagg gctacaggtt cagtgaacaa cagaggaaat     2760

gtgtggatat tgatgagtgt actcaggtcc aacacctctg ctcccagggc cgctgtgaaa     2820

acaccgaggg aagtttcttg tgcatttgcc cagcaggatt tatggccagt gaggagggta     2880

ctaactgcat agatgttgac gaatgcctga ggccggacgt ctgtggggag gggcactgtg     2940

tcaatactgt gggggccttc cggtgtgaat actgtgacag cgggtaccgc atgactcaga     3000

gaggccgttg tgaggatatt gatgaatgtt tgaatccaag cacttgtcca gatgagcagt     3060

gtgtgaattc tcctggatct taccagtgcg ttccctgcac agaaggattc cgaggctgga     3120

atggacagtg ccttgatgtg gacgagtgcc tggaaccaaa cgtctgcgca aatggtgatt     3180

gttccaacct tgaaggctcc tacatgtgtt catgccacaa aggctatacc cggactccgg     3240

accacaagca ctgtagagat attgatgaat gtcagcaagg gaatctatgt gtaaacgggc     3300

agtgcaaaaa taccgagggc tccttcaggt gcacctgtgg acaggggtac cagctgtcgg     3360

cagctaaaga ccagtgtgaa gacattgatg aatgccagca ccgtcatctc tgtgctcatg     3420

ggcagtgcag gaacactgag ggctcttttc aatgtgtgtg tgaccagggt tacagagcat     3480

ctgggcttgg agaccactgt gaagatatca atgaatgctt ggaggacaag agtgtttgcc     3540

agagaggaga ctgcattaat actgcagggt cctatgattg tacttgtccg gatggatttc     3600

agctagatga caataaaaca tgtcaagata ttaatgaatg tgaacatcca gggctctgtg     3660

gtccgcaagg ggagtgccta aacacagagg gttctttcca ttgtgtctgc cagcagggtt     3720

tctcaatctc tgcagatggc cgtacgtgtg aagatattga tgaatgtgta aacaacactg     3780

tttgtgacag tcacgggttt tgtgacaata cagctggctc cttccgctgc ctctgttatc     3840

agggctttca agccccacag gatgggcaag ggtgtgtgga tgtgaatgaa tgtgaactgc     3900

tcagtggggt gtgtggtgaa gccttctgtg aaaacgtgga agggtccttc ctgtgcgtgt     3960

gtgctgatga aaaccaagag tacagcccca tgactgggca gtgccgctcc cggacctcca     4020

cagatttaga tgtagatgta gatcaaccca aagaagaaaa gaaagaatgc tactataatc     4080

tcaatgacgc cagtctctgt gataatgtgt tggcccccaa tgtcacgaaa caagaatgct     4140

gctgtacatc aggcgcggga tggggagata actgcgaaat cttcccctgc ccggtcttgg     4200

gaactgctga gttcactgaa atgtgtccca aagggaaagg ttttgtgcct gctggagaat     4260

catcttctga agctggtggt gagaactata aagatgcaga tgaatgccta ctttttggac     4320

aagaaatctg caaaaatggt ttctgtttga acactcggcc tgggtatgaa tgctactgta     4380

agcaagggac gtactatgat cctgtgaaac tgcagtgctt tgatatggat gaatgtcaag     4440

accccagtag ttgtattgat ggccagtgtg ttaatacaga gggctcttac aactgcttct     4500

gtactcaccc catggtcctg gatgcgtcag aaaaaagatg tatacgaccg gctgagtcaa     4560

acgaacaaat agaagaaact gatgtctacc aagatttgtg ctgggaacat ctgagtgatg     4620

aatacgtgtg tagccggcct cttgtgggca agcagacaac gtacactgag tgctgctgtc     4680

tgtatggaga ggcctggggc atgcagtgtg ccctctgccc cctgaaggat tcagatgact     4740

atgctcagct gtgtaacatc cccgtgacgg gacgccggca gccatatgga cgggacgcct     4800

tggttgactt cagtgaacag tatactccag aagccgatcc ctacttcatc caagaccgtt     4860

ttctaaatag ctttgaggag ttacaggctg aggaatgcgg catcctcaat ggatgtgaaa     4920

atggtcgctg tgtgagggtc caggaaggtt acacctgcga ttgctttgat gggtatcact     4980

tggatacggc caagatgacc tgtgtcgatg taaatgaatg cgatgagttg aacaaccgga     5040

tgtctctctg caagaatgcc aagtgcatta acaccgatgg ttcctacaag tgtttgtgtc     5100

tgccaggcta cgtgccttct gacaagccaa actactgcac tccgttgaat accgccttga     5160

atttagagaa agacagtgac ctggagtgaa acagaatcta cataacctaa gcccatatac     5220

tctgcactgt gtaaaggaaa agggagaaat gtattatact tgagacattg cacctacccc     5280

ggaaggctgg aaatacagaa acagcatgga attgcaagtc ctctgaagac aatgagagga     5340

tttaggatga gcccgatagg tgtggcagac caaatggaca tttctctaaa aaaccagtat     5400

atatagtctg ttcatatgta aaattcaatg gaagagaggt ggaacagtgc tgttatttta     5460

aacagaaggt tgtattatta tgttgttttg tttttttact attgcttgat taaatttggc     5520

atttaaatag tggtggaaat attttatata attttcattt tttggttgtg cagttccttg     5580

gctactgttt ttcttttact tcagtttttt aaaaatctca aatgaaaaag tcttcgatac     5640

aatattgtta agctgtatta taagtattgt tacacagggt tatgcaattc ccggcctgga     5700

gcatttttga aattcaaatt gtctgtcctg tggagcaggc agtgattttg ttccaaaact     5760

ttgtatacac atttggagaa aagtacttta tattttcagt gttttgtctg attttaatgt     5820

ccgttcttag ccaagctgct agcaggtgtt aattggatcc ctttccttca ctgaaatgga     5880

agagtttata agcttacgtt agtattgtaa tatgtaaagt aagcccaaca aaaattttta     5940

aaaatttgat gatccccaat atatctacca ttgtatgtta aataaatcac catttttgta     6000

gaaaaaattc tacctgagag taattgtcaa tgagtacatg tgtataagtt gtatcccact     6060

ctccccactt ttatcttttc cagtggtctt ctgttaatgt agtgtctttt acaagttaat     6120

cattaaattt gttagatctt gttatgggct aaaaaaaaaa aaaaaaaa                  6168


<210> 31
<211> 114
<212> PRT
<213> Homo sapiens

<400> 31
Met Asn Val Leu Leu Gly Ser Val Val Ile Phe Ala Thr Phe Val Thr 
1               5                   10                  15      


Leu Cys Asn Ala Ser Cys Tyr Phe Ile Pro Asn Glu Gly Val Pro Gly 
            20                  25                  30          


Asp Ser Thr Arg Lys Cys Met Asp Leu Lys Gly Asn Lys His Pro Ile 
        35                  40                  45              


Asn Ser Glu Trp Gln Thr Asp Asn Cys Glu Thr Cys Thr Cys Tyr Glu 
    50                  55                  60                  


Thr Glu Ile Ser Cys Cys Thr Leu Val Ser Thr Pro Val Gly Tyr Asp 
65                  70                  75                  80  


Lys Asp Asn Cys Gln Arg Ile Phe Lys Lys Glu Asp Cys Lys Tyr Ile 
                85                  90                  95      


Val Val Glu Lys Lys Asp Pro Lys Lys Thr Cys Ser Val Ser Glu Trp 
            100                 105                 110         


Ile Ile 
        


<210> 32
<211> 76
<212> PRT
<213> Homo sapiens

<400> 32
Met Asn Val Leu Leu Gly Ser Val Val Ile Phe Ala Thr Phe Val Thr 
1               5                   10                  15      


Leu Cys Asn Ala Ser Cys Tyr Phe Ile Pro Asn Glu Gly Val Pro Gly 
            20                  25                  30          


Asp Ser Thr Arg Met Phe Leu His Leu Trp Val Met Thr Lys Thr Thr 
        35                  40                  45              


Ala Lys Glu Ser Ser Arg Arg Arg Thr Ala Ser Ile Ser Trp Trp Arg 
    50                  55                  60                  


Arg Arg Thr Gln Lys Arg Pro Val Leu Ser Val Asn 
65                  70                  75      


<210> 33
<211> 503
<212> DNA
<213> Homo sapiens

<400> 33
gtacctgtct ataaggagtc ctgcttatca caatgaatgt tctcctgggc agcgttgtga       60

tctttgccac cttcgtgact ttatgcaatg catcatgcta tttcatacct aatgagggag      120

ttccaggaga ttcaaccagg aaatgcatgg atctcaaagg aaacaaacac ccaataaact      180

cggagtggca gactgacaac tgtgagacat gcacttgcta cgaaacagaa atttcatgtt      240

gcacccttgt ttctacacct gtgggttatg acaaagacaa ctgccaaaga atcttcaaga      300

aggaggactg caagtatatc gtggtggaga agaaggaccc aaaaaagacc tgttctgtca      360

gtgaatggat aatctaatgt gcttctagta ggcacagggc tcccaggcca ggcctcattc      420

tcctctggcc tctaatagtc aatgattgtg tagccatgcc tatcagtaaa aagatttttg      480

agcaaacact tgaaaaaaaa aaa                                              503


<210> 34
<211> 397
<212> DNA
<213> Homo sapiens

<400> 34
gtacctgtct ataaggagtc ctgcttatca caatgaatgt tctcctgggc agcgttgtga       60

tctttgccac cttcgtgact ttatgcaatg catcatgcta tttcatacct aatgagggag      120

ttccaggaga ttcaaccagg atgtttctac acctgtgggt tatgacaaag acaactgcca      180

aagaatcttc aagaaggagg actgcaagta tatcgtggtg gagaagaagg acccaaaaaa      240

gacctgttct gtcagtgaat ggataatcta atgtgcttct agtaggcaca gggctcccag      300

gccaggcctc attctcctct ggcctctaat agtcaatgat tgtgtagcca tgcctatcag      360

taaaaagatt tttgagcaaa cacttgaaaa aaaaaaa                               397


<210> 35
<211> 510
<212> PRT
<213> Homo sapiens

<400> 35
Met Arg Pro Gly Leu Ser Phe Leu Leu Ala Leu Leu Phe Phe Leu Gly 
1               5                   10                  15      


Gln Ala Ala Gly Asp Leu Gly Asp Val Gly Pro Pro Ile Pro Ser Pro 
            20                  25                  30          


Gly Phe Ser Ser Phe Pro Gly Val Asp Ser Ser Ser Ser Phe Ser Ser 
        35                  40                  45              


Ser Ser Arg Ser Gly Ser Ser Ser Ser Arg Ser Leu Gly Ser Gly Gly 
    50                  55                  60                  


Ser Val Ser Gln Leu Phe Ser Asn Phe Thr Gly Ser Val Asp Asp Arg 
65                  70                  75                  80  


Gly Thr Cys Gln Cys Ser Val Ser Leu Pro Asp Thr Thr Phe Pro Val 
                85                  90                  95      


Asp Arg Val Glu Arg Leu Glu Phe Thr Ala His Val Leu Ser Gln Lys 
            100                 105                 110         


Phe Glu Lys Glu Leu Ser Lys Val Arg Glu Tyr Val Gln Leu Ile Ser 
        115                 120                 125             


Val Tyr Glu Lys Lys Leu Leu Asn Leu Thr Val Arg Ile Asp Ile Met 
    130                 135                 140                 


Glu Lys Asp Thr Ile Ser Tyr Thr Glu Leu Asp Phe Glu Leu Ile Lys 
145                 150                 155                 160 


Val Glu Val Lys Glu Met Glu Lys Leu Val Ile Gln Leu Lys Glu Ser 
                165                 170                 175     


Phe Gly Gly Ser Ser Glu Ile Val Asp Gln Leu Glu Val Glu Ile Arg 
            180                 185                 190         


Asn Met Thr Leu Leu Val Glu Lys Leu Glu Thr Leu Asp Lys Asn Asn 
        195                 200                 205             


Val Leu Ala Ile Arg Arg Glu Ile Val Ala Leu Lys Thr Lys Leu Lys 
    210                 215                 220                 


Glu Cys Glu Ala Ser Lys Asp Gln Asn Thr Pro Val Val His Pro Pro 
225                 230                 235                 240 


Pro Thr Pro Gly Ser Cys Gly His Gly Gly Val Val Asn Ile Ser Lys 
                245                 250                 255     


Pro Ser Val Val Gln Leu Asn Trp Arg Gly Phe Ser Tyr Leu Tyr Gly 
            260                 265                 270         


Ala Trp Gly Arg Asp Tyr Ser Pro Gln His Pro Asn Lys Gly Leu Tyr 
        275                 280                 285             


Trp Val Ala Pro Leu Asn Thr Asp Gly Arg Leu Leu Glu Tyr Tyr Arg 
    290                 295                 300                 


Leu Tyr Asn Thr Leu Asp Asp Leu Leu Leu Tyr Ile Asn Ala Arg Glu 
305                 310                 315                 320 


Leu Arg Ile Thr Tyr Gly Gln Gly Ser Gly Thr Ala Val Tyr Asn Asn 
                325                 330                 335     


Asn Met Tyr Val Asn Met Tyr Asn Thr Gly Asn Ile Ala Arg Val Asn 
            340                 345                 350         


Leu Thr Thr Asn Thr Ile Ala Val Thr Gln Thr Leu Pro Asn Ala Ala 
        355                 360                 365             


Tyr Asn Asn Arg Phe Ser Tyr Ala Asn Val Ala Trp Gln Asp Ile Asp 
    370                 375                 380                 


Phe Ala Val Asp Glu Asn Gly Leu Trp Val Ile Tyr Ser Thr Glu Ala 
385                 390                 395                 400 


Ser Thr Gly Asn Met Val Ile Ser Lys Leu Asn Asp Thr Thr Leu Gln 
                405                 410                 415     


Val Leu Asn Thr Trp Tyr Thr Lys Gln Tyr Lys Pro Ser Ala Ser Asn 
            420                 425                 430         


Ala Phe Met Val Cys Gly Val Leu Tyr Ala Thr Arg Thr Met Asn Thr 
        435                 440                 445             


Arg Thr Glu Glu Ile Phe Tyr Tyr Tyr Asp Thr Asn Thr Gly Lys Glu 
    450                 455                 460                 


Gly Lys Leu Asp Ile Val Met His Lys Met Gln Glu Lys Val Gln Ser 
465                 470                 475                 480 


Ile Asn Tyr Asn Pro Phe Asp Gln Lys Leu Tyr Val Tyr Asn Asp Gly 
                485                 490                 495     


Tyr Leu Leu Asn Tyr Asp Leu Ser Val Leu Gln Lys Pro Gln 
            500                 505                 510 


<210> 36
<211> 2935
<212> DNA
<213> Homo sapiens

<400> 36
ttttcctaca tgctggccat ggggaaatca ccactgggca ctataagaag cccctgggct       60

ctctgcagag ccagcggctc cagctaagag gacaagatga ggcccggcct ctcatttctc      120

ctagcccttc tgttcttcct tggccaagct gcaggggatt tgggggatgt gggacctcca      180

attcccagcc ccggcttcag ctctttccca ggtgttgact ccagctccag cttcagctcc      240

agctccaggt cgggctccag ctccagccgc agcttaggca gcggaggttc tgtgtcccag      300

ttgttttcca atttcaccgg ctccgtggat gaccgtggga cctgccagtg ctctgtttcc      360

ctgccagaca ccacctttcc cgtggacaga gtggaacgct tggaattcac agctcatgtt      420

ctttctcaga agtttgagaa agaactttcc aaagtgaggg aatatgtcca attaattagt      480

gtgtatgaaa agaaactgtt aaacctaact gtccgaattg acatcatgga gaaggatacc      540

atttcttaca ctgaactgga cttcgagctg atcaaggtag aagtgaagga gatggaaaaa      600

ctggtcatac agctgaagga gagttttggt ggaagctcag aaattgttga ccagctggag      660

gtggagataa gaaatatgac tctcttggta gagaagcttg agacactaga caaaaacaat      720

gtccttgcca ttcgccgaga aatcgtggct ctgaagacca agctgaaaga gtgtgaggcc      780

tctaaagatc aaaacacccc tgtcgtccac cctcctccca ctccagggag ctgtggtcat      840

ggtggtgtgg tgaacatcag caaaccgtct gtggttcagc tcaactggag agggttttct      900

tatctatatg gtgcttgggg tagggattac tctccccagc atccaaacaa aggactgtat      960

tgggtggcgc cattgaatac agatgggaga ctgttggagt attatagact gtacaacaca     1020

ctggatgatt tgctattgta tataaatgct cgagagttgc ggatcaccta tggccaaggt     1080

agtggtacag cagtttacaa caacaacatg tacgtcaaca tgtacaacac cgggaatatt     1140

gccagagtta acctgaccac caacacgatt gctgtgactc aaactctccc taatgctgcc     1200

tataataacc gcttttcata tgctaatgtt gcttggcaag atattgactt tgctgtggat     1260

gagaatggat tgtgggttat ttattcaact gaagccagca ctggtaacat ggtgattagt     1320

aaactcaatg acaccacact tcaggtgcta aacacttggt ataccaagca gtataaacca     1380

tctgcttcta acgccttcat ggtatgtggg gttctgtatg ccacccgtac tatgaacacc     1440

agaacagaag agatttttta ctattatgac acaaacacag ggaaagaggg caaactagac     1500

attgtaatgc ataagatgca ggaaaaagtg cagagcatta actataaccc ttttgaccag     1560

aaactttatg tctataacga tggttacctt ctgaattatg atctttctgt cttgcagaag     1620

ccccagtaag ctgtttagga gttagggtga aagagaaaat gtttgttgaa aaaatagtct     1680

tctccactta cttagatatc tgcaggggtg tctaaaagtg tgttcatttt gcagcaatgt     1740

ttaggtgcat agttctacca cactagagat ctaggacatt tgtcttgatt tggtgagttc     1800

tcttgggaat catctgcctc ttcaggcgca ttttgcaata aagtctgtct agggtgggat     1860

tgtcagaggt ctaggggcac tgtgggccta gtgaagccta ctgtgaggag gcttcactag     1920

aagccttaaa ttaggaatta aggaacttaa aactcagtat ggcgtctagg gattctttgt     1980

acaggaaata ttgcccaatg actagtcctc atccatgtag caccactaat tcttccatgc     2040

ctggaagaaa cctggggact tagttaggta gattaatatc tggagctcct cgagggacca     2100

aatctccaac ttttttttcc cctcactagc acctggaatg atgctttgta tgtggcagat     2160

aagtaaattt ggcatgctta tatattctac atctgtaaag tgctgagttt tatggagaga     2220

ggccttttta tgcattaaat tgtacatggc aaataaatcc cagaaggatc tgtagatgag     2280

gcacctgctt tttcttttct ctcattgtcc accttactaa aagtcagtag aatcttctac     2340

ctcataactt ccttccaaag gcagctcaga agattagaac cagacttact aaccaattcc     2400

accccccacc aacccccttc tactgcctac tttaaaaaaa ttaatagttt tctatggaac     2460

tgatctaaga ttagaaaaat taattttctt taatttcatt atgaactttt atttacatga     2520

ctctaagact ataagaaaat ctgatggcag tgacaaagtg ctagcattta ttgttatcta     2580

ataaagacct tggagcatat gtgcaactta tgagtgtatc agttgttgca tgtaattttt     2640

gcctttgttt aagcctggaa cttgtaagaa aatgaaaatt taattttttt ttctaggacg     2700

agctatagaa aagctattga gagtatctag ttaatcagtg cagtagttgg aaaccttgct     2760

ggtgtatgtg atgtgcttct gtgcttttga atgactttat catctagtct ttgtctattt     2820

ttcctttgat gttcaagtcc tagtctatag gattggcagt ttaaatgctt tactccccct     2880

tttaaaataa atgattaaaa tgtgctttga aaaaagtcaa aaaaaaaaaa aaaaa          2935


<210> 37
<211> 256
<212> PRT
<213> Homo sapiens

<400> 37
Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210> 38
<211> 256
<212> PRT
<213> Homo sapiens

<400> 38
Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210> 39
<211> 256
<212> PRT
<213> Homo sapiens

<400> 39
Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210> 40
<211> 1035
<212> DNA
<213> Homo sapiens

<400> 40
gagtggggga gagagaggag accaggacag ctgctgagac ctctaagaag tccagatact       60

aagagcaaag atgtttcaaa ctgggggcct cattgtcttc tacgggctgt tagcccagac      120

catggcccag tttggaggcc tgcccgtgcc cctggaccag accctgccct tgaatgtgaa      180

tccagccctg cccttgagtc ccacaggtct tgcaggaagc ttgacaaatg ccctcagcaa      240

tggcctgctg tctgggggcc tgttgggcat tctggaaaac cttccgctcc tggacatcct      300

gaagcctgga ggaggtactt ctggtggcct ccttggggga ctgcttggaa aagtgacgtc      360

agtgattcct ggcctgaaca acatcattga cataaaggtc actgaccccc agctgctgga      420

acttggcctt gtgcagagcc ctgatggcca ccgtctctat gtcaccatcc ctctcggcat      480

aaagctccaa gtgaatacgc ccctggtcgg tgcaagtctg ttgaggctgg ctgtgaagct      540

ggacatcact gcagaaatct tagctgtgag agataagcag gagaggatcc acctggtcct      600

tggtgactgc acccattccc ctggaagcct gcaaatttct ctgcttgatg gacttggccc      660

cctccccatt caaggtcttc tggacagcct cacagggatc ttgaataaag tcctgcctga      720

gttggttcag ggcaacgtgt gccctctggt caatgaggtt ctcagaggct tggacatcac      780

cctggtgcat gacattgtta acatgctgat ccacggacta cagtttgtca tcaaggtcta      840

agccttccag gaaggggctg gcctctgctg agctgcttcc cagtgctcac agatggctgg      900

cccatgtgct ggaagatgac acagttgcct tctctccgag gaacctgccc cctctccttt      960

cccaccaggc gtgtgtaaca tcccatgtgc ctcacctaat aaaatggctc ttcttctgca     1020

tcaaaaaaaa aaaaa                                                      1035


<210> 41
<211> 1090
<212> DNA
<213> Homo sapiens

<400> 41
gagtggggga gagagaggag accaggacag ctgctgagac ctctaagaag tccagatact       60

aagagcaaag atgtttcaaa ctgggggcct cattgtcttc tacgggctgt tagcccagac      120

catggcccag tttggaggcc tgcccgtgcc cctggaccag accctgccct tgaatgtgaa      180

tccagccctg cccttgagtc ccacaggtct tgcaggaagc ttgacaaatg ccctcagcaa      240

tggcctgctg tctgggggcc tgttgggcat tctggaaaac cttccgctcc tggacatcct      300

gaagcctgga ggaggtactt ctggtggcct ccttggggga ctgcttggaa aagtgacgtc      360

agtgattcct ggcctgaaca acatcattga cataaaggtc actgaccccc agctgctgga      420

acttggcctt gtgcagagcc ctgatggcca ccgtctctat gtcaccatcc ctctcggcat      480

aaagctccaa gtgaatacgc ccctggtcgg tgcaagtctg ttgaggctgg ctgtgaagct      540

ggacatcact gcagaaatct tagctgtgag agataagcag gagaggatcc acctggtcct      600

tggtgactgc acccattccc ctggaagcct gcaaatttct ctgcttgatg gacttggccc      660

cctccccatt caaggtcttc tggacagcct cacagggatc ttgaataaag tcctgcctga      720

gttggttcag ggcaacgtgt gccctctggt caatgaggtt ctcagaggct tggacatcac      780

cctggtgcat gacattgtta acatgctgat ccacggacta cagtttgtca tcaaggtcta      840

agccttccag gaaggggctg gcctctgctg agctgggtct tcccccaaca gaactatttc      900

ttgctgctca atccatttcc tctggcccag cttcccagtg ctcacagatg gctggcccat      960

gtgctggaag atgacacagt tgccttctct ccgaggaacc tgccccctct cctttcccac     1020

caggcgtgtg taacatccca tgtgcctcac ctaataaaat ggctcttctt ctgcatcaaa     1080

aaaaaaaaaa                                                            1090


<210> 42
<211> 1074
<212> DNA
<213> Homo sapiens

<400> 42
gagtggggga gagagaggag accaggacag ctgctgagac ctctaagaag tccagatact       60

aagagcaaag atgtttcaaa ctgggggcct cattgtcttc tacgggctgt tagcccagac      120

catggcccag tttggaggcc tgcccgtgcc cctggaccag accctgccct tgaatgtgaa      180

tccagccctg cccttgagtc ccacaggtct tgcaggaagc ttgacaaatg ccctcagcaa      240

tggcctgctg tctgggggcc tgttgggcat tctggaaaac cttccgctcc tggacatcct      300

gaagcctgga ggaggtactt ctggtggcct ccttggggga ctgcttggaa aagtgacgtc      360

agtgattcct ggcctgaaca acatcattga cataaaggtc actgaccccc agctgctgga      420

acttggcctt gtgcagagcc ctgatggcca ccgtctctat gtcaccatcc ctctcggcat      480

aaagctccaa gtgaatacgc ccctggtcgg tgcaagtctg ttgaggctgg ctgtgaagct      540

ggacatcact gcagaaatct tagctgtgag agataagcag gagaggatcc acctggtcct      600

tggtgactgc acccattccc ctggaagcct gcaaatttct ctgcttgatg gacttggccc      660

cctccccatt caaggtcttc tggacagcct cacagggatc ttgaataaag tcctgcctga      720

gttggttcag ggcaacgtgt gccctctggt caatgaggtt ctcagaggct tggacatcac      780

cctggtgcat gacattgtta acatgctgat ccacggacta cagtttgtca tcaaggtcta      840

agccttccag gaaggggctg gcctctgctg agctgaacta tttcttgctg ctcaatccat      900

ttcctctggc ccagcttccc agtgctcaca gatggctggc ccatgtgctg gaagatgaca      960

cagttgcctt ctctccgagg aacctgcccc ctctcctttc ccaccaggcg tgtgtaacat     1020

cccatgtgcc tcacctaata aaatggctct tcttctgcat caaaaaaaaa aaaa           1074


<210> 43
<211> 128
<212> PRT
<213> Homo sapiens

<400> 43
Met Ser Leu Arg Leu Asp Thr Thr Pro Ser Cys Asn Ser Ala Arg Pro 
1               5                   10                  15      


Leu His Ala Leu Gln Val Leu Leu Leu Leu Ser Leu Leu Leu Thr Ala 
            20                  25                  30          


Leu Ala Ser Ser Thr Lys Gly Gln Thr Lys Arg Asn Leu Ala Lys Gly 
        35                  40                  45              


Lys Glu Glu Ser Leu Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met 
    50                  55                  60                  


Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu 
65                  70                  75                  80  


Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala 
                85                  90                  95      


Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg 
            100                 105                 110         


Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp 
        115                 120                 125             


<210> 44
<211> 1307
<212> DNA
<213> Homo sapiens

<400> 44
acttatctgc agacttgtag gcagcaactc accctcactc agaggtcttc tggttctgga       60

aacaactcta gctcagcctt ctccaccatg agcctcagac ttgataccac cccttcctgt      120

aacagtgcga gaccacttca tgccttgcag gtgctgctgc ttctgtcatt gctgctgact      180

gctctggctt cctccaccaa aggacaaact aagagaaact tggcgaaagg caaagaggaa      240

agtctagaca gtgacttgta tgctgaactc cgctgcatgt gtataaagac aacctctgga      300

attcatccca aaaacatcca aagtttggaa gtgatcggga aaggaaccca ttgcaaccaa      360

gtcgaagtga tagccacact gaaggatggg aggaaaatct gcctggaccc agatgctccc      420

agaatcaaga aaattgtaca gaaaaaattg gcaggtgatg aatctgctga ttaatttgtt      480

ctgtttctgc caaacttctt taactcccag gaagggtaga attttgaaac cttgattttc      540

tagagttctc atttattcag gatacctatt cttactgtat taaaatttgg atatgtgttt      600

cattctgtct caaaaatcac attttattct gagaaggttg gttaaaagat ggcagaaaga      660

agatgaaaat aaataagcct ggtttcaacc ctctaattct tgcctaaaca ttggactgta      720

ctttgcattt ttttctttaa aaatttctat tctaacacaa cttggttgat ttttcctggt      780

ctactttatg gttattagac atactcatgg gtattattag atttcataat ggtcaatgat      840

aataggaatt acatggagcc caacagagaa tatttgctca atacattttt gttaatatat      900

ttaggaactt aatggagtct ctcagtgtct tagtcctagg atgtcttatt taaaatactc      960

cctgaaagtt tattctgatg tttattttag ccatcaaaca ctaaaataat aaattggtga     1020

atatgaatct tataaactgt ggttagctgg tttaaagtga atatatttgc cactagtaga     1080

acaaaaatag atgatgaaaa tgaattaaca tatctacata gttataattc tatcattaga     1140

atgagcctta taaataagta caatatagga cttcaacctt actagactcc taattctaaa     1200

ttctactttt ttcatcaaca gaactttcat tcatttttta aaccctaaaa cttataccca     1260

cactattctt acaaaaatat tcacatgaaa taaaaatttg ctattga                   1307


<210> 45
<211> 423
<212> PRT
<213> Homo sapiens

<400> 45
Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly 
1               5                   10                  15      


Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu 
            20                  25                  30          


Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly 
        35                  40                  45              


Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu 
    50                  55                  60                  


Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile 
65                  70                  75                  80  


Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu 
                85                  90                  95      


Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu 
            100                 105                 110         


Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn Gln 
        115                 120                 125             


Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys 
    130                 135                 140                 


Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu 
145                 150                 155                 160 


Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala 
                165                 170                 175     


Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile 
            180                 185                 190         


Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu Val 
        195                 200                 205             


Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln 
    210                 215                 220                 


Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met 
225                 230                 235                 240 


Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp 
                245                 250                 255     


Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala 
            260                 265                 270         


Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu 
        275                 280                 285             


Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu 
    290                 295                 300                 


Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg 
305                 310                 315                 320 


Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala 
                325                 330                 335     


Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu 
            340                 345                 350         


Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val Phe Glu Glu 
        355                 360                 365             


Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser 
    370                 375                 380                 


Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 
385                 390                 395                 400 


Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys 
                405                 410                 415     


Val Thr Asn Pro Lys Gln Ala 
            420             


<210> 46
<211> 1629
<212> DNA
<213> Homo sapiens

<400> 46
attcatgaaa atccactact ccagacagac ggctttggaa tccaccagct acatccagct       60

ccctgaggca gagttgagaa tggagagaat gttacctctc ctggctctgg ggctcttggc      120

ggctgggttc tgccctgctg tcctctgcca ccctaacagc ccacttgacg aggagaatct      180

gacccaggag aaccaagacc gagggacaca cgtggacctc ggattagcct ccgccaacgt      240

ggacttcgct ttcagcctgt acaagcagtt agtcctgaag gcccctgata agaatgtcat      300

cttctcccca ctgagcatct ccaccgcctt ggccttcctg tctctggggg cccataatac      360

caccctgaca gagattctca aaggcctcaa gttcaacctc acggagactt ctgaggcaga      420

aattcaccag agcttccagc acctcctgcg caccctcaat cagtccagcg atgagctgca      480

gctgagtatg ggaaatgcca tgtttgtcaa agagcaactc agtctgctgg acaggttcac      540

ggaggatgcc aagaggctgt atggctccga ggcctttgcc actgactttc aggactcagc      600

tgcagctaag aagctcatca acgactacgt gaagaatgga actaggggga aaatcacaga      660

tctgatcaag gaccttgact cgcagacaat gatggtcctg gtgaattaca tcttctttaa      720

agccaaatgg gagatgccct ttgaccccca agatactcat cagtcaaggt tctacttgag      780

caagaaaaag tgggtaatgg tgcccatgat gagtttgcat cacctgacta taccttactt      840

ccgggacgag gagctgtcct gcaccgtggt ggagctgaag tacacaggca atgccagcgc      900

actcttcatc ctccctgatc aagacaagat ggaggaagtg gaagccatgc tgctcccaga      960

gaccctgaag cggtggagag actctctgga gttcagagag ataggtgagc tctacctgcc     1020

aaagttttcc atctcgaggg actataacct gaacgacata cttctccagc tgggcattga     1080

ggaagccttc accagcaagg ctgacctgtc agggatcaca ggggccagga acctagcagt     1140

ctcccaggtg gtccataagg ctgtgcttga tgtatttgag gagggcacag aagcatctgc     1200

tgccacagca gtcaaaatca ccctcctttc tgcattagtg gagacaagga ccattgtgcg     1260

tttcaacagg cccttcctga tgatcattgt ccctacagac acccagaaca tcttcttcat     1320

gagcaaagtc accaatccca agcaagccta gagcttgcca tcaagcagtg gggctctcag     1380

taaggaactt ggaatgcaag ctggatgcct gggtctctgg gcacagcctg gcccctgtgc     1440

accgagtggc catggcatgt gtggccctgt ctgcttatcc ttggaaggtg acagcgattc     1500

cctgtgtagc tctcacatgc acaggggccc atggactctt cagtctggag ggtcctgggc     1560

ctcctgacag caataaataa tttcgttgga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaa                                                             1629


<210> 47
<211> 251
<212> PRT
<213> Homo sapiens

<400> 47
Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210> 48
<211> 192
<212> PRT
<213> Homo sapiens

<400> 48
Met Gln Leu Thr Lys Gly Arg Leu His Phe Ser His Pro Leu Ser His 
1               5                   10                  15      


Thr Lys His Ile Ser Pro Phe Val Thr Asp Ala Pro Leu Arg Ala Asp 
            20                  25                  30          


Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr 
        35                  40                  45              


Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu 
    50                  55                  60                  


Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu 
65                  70                  75                  80  


Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe 
                85                  90                  95      


Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro 
            100                 105                 110         


Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser 
        115                 120                 125             


Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu 
    130                 135                 140                 


Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser 
145                 150                 155                 160 


Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu 
                165                 170                 175     


Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
            180                 185                 190         


<210> 49
<211> 6705
<212> DNA
<213> Homo sapiens

<400> 49
ggaaaaggga aggaggagac tgagtgatta agtcacccac tgtgagagct ggtcttctat       60

ttaatggggg ctctctctgc ccaggagtca gaggtgcctc caggagcagc aggagcatgg      120

ccgaggatct gggactgagc tttggggaaa cagccagtgt ggaaatgctg ccagagcacg      180

gcagctgcag gcccaaggcc aggagcagca gcgcacgctg ggctctcacc tgctgcctgg      240

tgttgctccc cttccttgca ggactcacca catacctgct tgtcagccag ctccgggccc      300

agggagaggc ctgtgtgcag ttccaggctc taaaaggaca ggagtttgca ccttcacatc      360

agcaagttta tgcacctctt agagcagacg gagataagcc aagggcacac ctgacagttg      420

tgagacaaac tcccacacag cactttaaaa atcagttccc agctctgcac tgggaacatg      480

aactaggcct ggccttcacc aagaaccgaa tgaactatac caacaaattc ctgctgatcc      540

cagagtcggg agactacttc atttactccc aggtcacatt ccgtgggatg acctctgagt      600

gcagtgaaat cagacaagca ggccgaccaa acaagccaga ctccatcact gtggtcatca      660

ccaaggtaac agacagctac cctgagccaa cccagctcct catggggacc aagtctgtat      720

gcgaagtagg tagcaactgg ttccagccca tctacctcgg agccatgttc tccttgcaag      780

aaggggacaa gctaatggtg aacgtcagtg acatctcttt ggtggattac acaaaagaag      840

ataaaacctt ctttggagcc ttcttactat aggaggagag caaatatcat tatatgaaag      900

tcctctgcca ccgagttcct aattttcttt gttcaaatgt aattataacc aggggttttc      960

ttggggccgg gagtaggggg cattccacag ggacaacggt ttagctatga aatttggggc     1020

ccaaaatttc acacttcatg tgccttactg atgagagtac taactggaaa aaggctgaag     1080

agagcaaata tattattaag atgggttgga ggattggcga gtttctaaat attaagacac     1140

tgatcactaa atgaatggat gatctactcg ggtcaggatt gaaagagaaa tatttcaaca     1200

ccttcctgct atacaatggt caccagtggt ccagttattg ttcaatttga tcataaattt     1260

gcttcaattc aggagctttg aaggaagtcc aaggaaagct ctagaaaaca gtataaactt     1320

tcagaggcaa aatccttcac caatttttcc acatactttc atgccttgcc taaaaaaaat     1380

gaaaagagag ttggtatgtc tcatgaatgt tcacacagaa ggagttggtt ttcatgtcat     1440

ctacagcata tgagaaaagc tacctttctt ttgattatgt acacagatat ctaaataagg     1500

aagtatgagt ttcacatgta tatcaaaaat acaacagttg cttgtattca gtagagtttt     1560

cttgcccacc tattttgtgc tgggttctac cttaacccag aagacactat gaaaaacaag     1620

acagactcca ctcaaaattt atatgaacac cactagatac ttcctgatca aacatcagtc     1680

aacatactct aaagaataac tccaagtctt ggccaggcgc agtggctcac acctgtaatc     1740

ccaacacttt gggaggccaa ggtgggtgga tcatctaagg ccgggagttc aagaccagcc     1800

tgaccaacgt ggagaaaccc catctctact aaaaatacaa aattagccgg gcgtggtagc     1860

gcatggctgt aatcctggct actcaggagg ccgaggcaga agaattgctt gaactgggga     1920

ggcagaggtt gcggtgagcc cagatcgcgc cattgcactc cagcctgggt aacaagagca     1980

aaactctgtc caaaaaaaaa aaaataaaat aataactcca agcctttaaa aaatatcatc     2040

tgaaactgtt acatcagatt tctggcactc tactgactgt ggaagatagc cagctgactg     2100

gaagatagcc agctgattag ttccctgaag aaacctgaag acagatacct ggttaactag     2160

atcaactaca ctgccaactt gtttgatgct gagagacaat ggacttattc catgggggaa     2220

gggaaaaaag aagtcaatca ccaaatctga agaagttaac ctagatcttt gaggtttgat     2280

ttgcaacttt atatgcagag tattatgtgg gtattttccc ttaaaatatt caaagggatt     2340

tacatatggg attagctaat gagcctagcc aagaccttcc ctggaggaca ggctggtcat     2400

tgcggaggtc ccttctgtgc ttcagtgggt tcatatcctc tagtccgtat gattttccta     2460

cgctaatatg tcaagggcag gagaggcagc tctgttctcc tagcctttgt tgacttgtct     2520

gcaaagcagg aatctgccca tttgtttcca aggagcaaat gagctcatga gaatgaaaga     2580

tgttaacttc atgcattctg tgccatctga gcatttcggt attatatgac tggtgaccct     2640

tggcccgtat tataaatgct tcctatcctg ggagacctca tggatgagtc tgagaggaaa     2700

tttggcacca aaatcactct cactctggtt tccagtagac tatagaggca gagaggcatt     2760

tgagaggctc ctgagcaaag tgtccagtgt agcaggagca cttcattaat atttattgag     2820

ttataattaa ataaaaatta atttctgatt tctcagtttg gaggttaagg ctctaaatat     2880

attttctaac ctctgctagg ctaacttaag ccaggccttt ttcttgcctt ccctttctca     2940

aaacagtcag cacagactca gtgggagcac agaggagtgt ggtcacctcc acctggctca     3000

ccagagtctt catagaggaa gtgaagcctg gaagaaactg ggcgggcccc agatgaccac     3060

agggaaaggg catctcagat ggaggaatta cccttgactt aaagcagaaa agaaagattt     3120

ctcagtaact ccaaaacttg cttgatagga gaatattccc tcaaccaatt cctaggacaa     3180

tatttattgg tagatcaaga atgtttcctc aataactcta gtctagctcc atgatcagaa     3240

ctaacaccca ttaaaaacat aaaatgttct ttctgaaccg gtcttcatgg tgcgtgagag     3300

caccaagcag ctttggtatg caggaggagt tttgcacaga agagtggcct gctcaaacct     3360

gcccactgtt ctgtaggtga tctggtggat ctggaaattt atcccaagac aggaatttcc     3420

taatattcga agacatttga ggctttggga aattctctgc tgtgcattta tttggctcct     3480

gtcataagct tgttttttaa agaatgtatc atagctcaag tttttactgc tgattttgtt     3540

aaattctgta tagtatattt tttacggaaa ggcacagtca gacattccta atagggctca     3600

tgtcagaact tctgttccca aggcattatc tccatagcaa aaattagtgc actgttttca     3660

aaagtgaggt gggaaaatgc ttttaagatc atgtgatgtt cccctaaaag gggttaatgg     3720

ggtgtattca gggtttggga gggaggaaga agcatgcttt agaaaacagt aaatttaggg     3780

agaaaatgct ttgttggtta aatgtcactc aaaaggctga attcaaatca attccacaaa     3840

catttactga gtacctactg cccctgggga cacagagata aattatttag tctcagacac     3900

actcattcta acttcccagc acctctactg tctgcagatt ctttaattta ttttggttgt     3960

attagctaat taattcgtaa actttaggca catggatcta ttctcattat gaaaatggat     4020

gccatttgat taaggctgat gactaacaaa atgatttgtg tttactcgaa gtgttttttt     4080

aaaaatagct actcaaggat agttttccat aaatcaagaa ggtaaaaaag ttcccatttt     4140

ttattgtaga atccattatt taaactacat gtagagacag gttattattt gctatattca     4200

agtttggtca tcaataccct taaaaatatt agaattttat ggatgaccca gaaatgcttt     4260

gaaaatctgt gttcctcagc aaatacagag accatgatca aaatgcacag aatcactaac     4320

attttgatgc tagcatggtt tcagtctatt tggcagaaca gaattgatta tgctactaaa     4380

atttcttttt cttttttttt tttttttttt ttgagacaga gtcttgcttt gtcacccagg     4440

ctgaagtgca gtggcaggat ctcagttcac tgcaacctct gcctcccagg ttcacgccat     4500

tctcctgctt cagcctcccg agtagctggg actacaggct cccaccacca tgcccggcta     4560

attttttgca tttttagtag agacggggtt tcaccgtgtt agccaggatg gtctcgatct     4620

cctgacctcg tgatccgccc gcctcagcct tccaaagtgc tgggattaca ggcgtgagcc     4680

actgtgcccg gactctgatt ttttttttac taaggtacag taagaaaagg gaaaagtgta     4740

cgttttcact tcctgaaata tgtcaggttg aatcaataat agagcacacc agaactcttg     4800

gctccatttc aacctaaact attcagttct catcacccca gaggaaattc cgcctctgtg     4860

ctggtcagta atccccctgg attataaaag tttaactaac tcactgtgca caaggcacgg     4920

ccattgccaa cattctcttg caaggtattt tcccaagccc ttacccaatt ctgtttccat     4980

gattgtgaca ttggggatta attctgcaag acagaactgt ttatattctg taccttaaaa     5040

acacatgcaa acatctcttg ccttaagatt tctggctttc ctatggccca gagtcctaga     5100

agtgttttga tatttgtagc agaattttca agtgtacatc cttatcctgg atattaacat     5160

ttttgcatca tattggcagc tggacctaca gagaatttag tagactgtta acctaataag     5220

ccttgaatcc ttttgcacca gtggtgagag aatgtggatc agagccatca cctccatgcc     5280

ccgtcaccct ctaacaacca catttacaac ttccccagct ctgagacaca cttgcctcca     5340

ccccttccat caccccattt taagatgaaa ataccacacc agcctggaag gaagaagtta     5400

cttgcccagg gccacatagt gagttaaggg ctgatctaga gctaggaagc tgtcttcctg     5460

aaccataatc ctggactctt ctaacctctc tactcatcgc aaatagagtt cattttagtg     5520

atttgaagga agatgggaca agtattttca aacacctgta ggacaacatg gaagtgggag     5580

gagacttcta ctgtagctcc ccagagaaga gagctagggc tacagagttg cagttacaag     5640

gttgccctct ctggcttgat ccccaaagga attttctact ccaaaataga atttttctag     5700

gatgctattt ctcagtccct ggagatactc aaacaaaggg cttgtcacaa gggtttttgt     5760

agaagctatt cttcacagag gttgggggag agattaagcc aaaggatctc tgaggtcttt     5820

ttcaaatcta taattatgtg gccttttgtt cattgacttc catgtgttct agttgatcat     5880

tacaaacctg gcaggccttc tcaagggttc agtaattagc tgtcatttcc catttgtcca     5940

gagagtgtcc aacacaaaat acccctaaga tcttggccaa tagagaaatg tcatggaatt     6000

ttagaaatga cagtatctgc ggagtttatt ccaagttata tcatttcaaa gatgaagaaa     6060

cccaggctca gagggagcca tcacatccac accctgtcac ccttcgtggc cagtgccaga     6120

cagtagctag ttggatgcta aaagtagaat ttagatatct taacaataag cccagcagtc     6180

tttcaacttc attcgtaaat catttttgtt ttgagcatct gtcacgtggc agcacttgcc     6240

tggatactgg agagctgaga aggaatgcga caggcaagtc ctactctcac agtgtataca     6300

ttcaggagga acaagacaca cagtgccaag taaataaagt agctgaactt catcaaatga     6360

ttttattctt aaagtcatta aagcatgtaa tgttcccctt tttttgtttc aggggtgtac     6420

agattgaaga agtgtaggtg tttatgtggt tttagtgaca aaccccatgt gctttcattg     6480

attttatgtt ttatgttaaa acatcaaccg caaggtaaaa tgcatattgt atgttgttgg     6540

atacgtactt aactggtatg catcccatgt ctttgggtac tagtgtatga attctaatct     6600

ctgtaaatga aatgttgtat gtgttaatat atttaataga tgtaacttaa taaactggca     6660

ttgaagactg aagaattttc acactgtcaa aaaaaaaaaa aaaaa                     6705


<210> 50
<211> 6412
<212> DNA
<213> Homo sapiens

<400> 50
atgcaactca caaagggccg tcttcatttc agtcaccctt tgtctcatac aaagcacatt       60

tctccttttg ttacagatgc acctcttaga gcagacggag ataagccaag ggcacacctg      120

acagttgtga gacaaactcc cacacagcac tttaaaaatc agttcccagc tctgcactgg      180

gaacatgaac taggcctggc cttcaccaag aaccgaatga actataccaa caaattcctg      240

ctgatcccag agtcgggaga ctacttcatt tactcccagg tcacattccg tgggatgacc      300

tctgagtgca gtgaaatcag acaagcaggc cgaccaaaca agccagactc catcactgtg      360

gtcatcacca aggtaacaga cagctaccct gagccaaccc agctcctcat ggggaccaag      420

tctgtatgcg aagtaggtag caactggttc cagcccatct acctcggagc catgttctcc      480

ttgcaagaag gggacaagct aatggtgaac gtcagtgaca tctctttggt ggattacaca      540

aaagaagata aaaccttctt tggagccttc ttactatagg aggagagcaa atatcattat      600

atgaaagtcc tctgccaccg agttcctaat tttctttgtt caaatgtaat tataaccagg      660

ggttttcttg gggccgggag tagggggcat tccacaggga caacggttta gctatgaaat      720

ttggggccca aaatttcaca cttcatgtgc cttactgatg agagtactaa ctggaaaaag      780

gctgaagaga gcaaatatat tattaagatg ggttggagga ttggcgagtt tctaaatatt      840

aagacactga tcactaaatg aatggatgat ctactcgggt caggattgaa agagaaatat      900

ttcaacacct tcctgctata caatggtcac cagtggtcca gttattgttc aatttgatca      960

taaatttgct tcaattcagg agctttgaag gaagtccaag gaaagctcta gaaaacagta     1020

taaactttca gaggcaaaat ccttcaccaa tttttccaca tactttcatg ccttgcctaa     1080

aaaaaatgaa aagagagttg gtatgtctca tgaatgttca cacagaagga gttggttttc     1140

atgtcatcta cagcatatga gaaaagctac ctttcttttg attatgtaca cagatatcta     1200

aataaggaag tatgagtttc acatgtatat caaaaataca acagttgctt gtattcagta     1260

gagttttctt gcccacctat tttgtgctgg gttctacctt aacccagaag acactatgaa     1320

aaacaagaca gactccactc aaaatttata tgaacaccac tagatacttc ctgatcaaac     1380

atcagtcaac atactctaaa gaataactcc aagtcttggc caggcgcagt ggctcacacc     1440

tgtaatccca acactttggg aggccaaggt gggtggatca tctaaggccg ggagttcaag     1500

accagcctga ccaacgtgga gaaaccccat ctctactaaa aatacaaaat tagccgggcg     1560

tggtagcgca tggctgtaat cctggctact caggaggccg aggcagaaga attgcttgaa     1620

ctggggaggc agaggttgcg gtgagcccag atcgcgccat tgcactccag cctgggtaac     1680

aagagcaaaa ctctgtccaa aaaaaaaaaa ataaaataat aactccaagc ctttaaaaaa     1740

tatcatctga aactgttaca tcagatttct ggcactctac tgactgtgga agatagccag     1800

ctgactggaa gatagccagc tgattagttc cctgaagaaa cctgaagaca gatacctggt     1860

taactagatc aactacactg ccaacttgtt tgatgctgag agacaatgga cttattccat     1920

gggggaaggg aaaaaagaag tcaatcacca aatctgaaga agttaaccta gatctttgag     1980

gtttgatttg caactttata tgcagagtat tatgtgggta ttttccctta aaatattcaa     2040

agggatttac atatgggatt agctaatgag cctagccaag accttccctg gaggacaggc     2100

tggtcattgc ggaggtccct tctgtgcttc agtgggttca tatcctctag tccgtatgat     2160

tttcctacgc taatatgtca agggcaggag aggcagctct gttctcctag cctttgttga     2220

cttgtctgca aagcaggaat ctgcccattt gtttccaagg agcaaatgag ctcatgagaa     2280

tgaaagatgt taacttcatg cattctgtgc catctgagca tttcggtatt atatgactgg     2340

tgacccttgg cccgtattat aaatgcttcc tatcctggga gacctcatgg atgagtctga     2400

gaggaaattt ggcaccaaaa tcactctcac tctggtttcc agtagactat agaggcagag     2460

aggcatttga gaggctcctg agcaaagtgt ccagtgtagc aggagcactt cattaatatt     2520

tattgagtta taattaaata aaaattaatt tctgatttct cagtttggag gttaaggctc     2580

taaatatatt ttctaacctc tgctaggcta acttaagcca ggcctttttc ttgccttccc     2640

tttctcaaaa cagtcagcac agactcagtg ggagcacaga ggagtgtggt cacctccacc     2700

tggctcacca gagtcttcat agaggaagtg aagcctggaa gaaactgggc gggccccaga     2760

tgaccacagg gaaagggcat ctcagatgga ggaattaccc ttgacttaaa gcagaaaaga     2820

aagatttctc agtaactcca aaacttgctt gataggagaa tattccctca accaattcct     2880

aggacaatat ttattggtag atcaagaatg tttcctcaat aactctagtc tagctccatg     2940

atcagaacta acacccatta aaaacataaa atgttctttc tgaaccggtc ttcatggtgc     3000

gtgagagcac caagcagctt tggtatgcag gaggagtttt gcacagaaga gtggcctgct     3060

caaacctgcc cactgttctg taggtgatct ggtggatctg gaaatttatc ccaagacagg     3120

aatttcctaa tattcgaaga catttgaggc tttgggaaat tctctgctgt gcatttattt     3180

ggctcctgtc ataagcttgt tttttaaaga atgtatcata gctcaagttt ttactgctga     3240

ttttgttaaa ttctgtatag tatatttttt acggaaaggc acagtcagac attcctaata     3300

gggctcatgt cagaacttct gttcccaagg cattatctcc atagcaaaaa ttagtgcact     3360

gttttcaaaa gtgaggtggg aaaatgcttt taagatcatg tgatgttccc ctaaaagggg     3420

ttaatggggt gtattcaggg tttgggaggg aggaagaagc atgctttaga aaacagtaaa     3480

tttagggaga aaatgctttg ttggttaaat gtcactcaaa aggctgaatt caaatcaatt     3540

ccacaaacat ttactgagta cctactgccc ctggggacac agagataaat tatttagtct     3600

cagacacact cattctaact tcccagcacc tctactgtct gcagattctt taatttattt     3660

tggttgtatt agctaattaa ttcgtaaact ttaggcacat ggatctattc tcattatgaa     3720

aatggatgcc atttgattaa ggctgatgac taacaaaatg atttgtgttt actcgaagtg     3780

tttttttaaa aatagctact caaggatagt tttccataaa tcaagaaggt aaaaaagttc     3840

ccatttttta ttgtagaatc cattatttaa actacatgta gagacaggtt attatttgct     3900

atattcaagt ttggtcatca atacccttaa aaatattaga attttatgga tgacccagaa     3960

atgctttgaa aatctgtgtt cctcagcaaa tacagagacc atgatcaaaa tgcacagaat     4020

cactaacatt ttgatgctag catggtttca gtctatttgg cagaacagaa ttgattatgc     4080

tactaaaatt tctttttctt tttttttttt tttttttttg agacagagtc ttgctttgtc     4140

acccaggctg aagtgcagtg gcaggatctc agttcactgc aacctctgcc tcccaggttc     4200

acgccattct cctgcttcag cctcccgagt agctgggact acaggctccc accaccatgc     4260

ccggctaatt ttttgcattt ttagtagaga cggggtttca ccgtgttagc caggatggtc     4320

tcgatctcct gacctcgtga tccgcccgcc tcagccttcc aaagtgctgg gattacaggc     4380

gtgagccact gtgcccggac tctgattttt tttttactaa ggtacagtaa gaaaagggaa     4440

aagtgtacgt tttcacttcc tgaaatatgt caggttgaat caataataga gcacaccaga     4500

actcttggct ccatttcaac ctaaactatt cagttctcat caccccagag gaaattccgc     4560

ctctgtgctg gtcagtaatc cccctggatt ataaaagttt aactaactca ctgtgcacaa     4620

ggcacggcca ttgccaacat tctcttgcaa ggtattttcc caagccctta cccaattctg     4680

tttccatgat tgtgacattg gggattaatt ctgcaagaca gaactgttta tattctgtac     4740

cttaaaaaca catgcaaaca tctcttgcct taagatttct ggctttccta tggcccagag     4800

tcctagaagt gttttgatat ttgtagcaga attttcaagt gtacatcctt atcctggata     4860

ttaacatttt tgcatcatat tggcagctgg acctacagag aatttagtag actgttaacc     4920

taataagcct tgaatccttt tgcaccagtg gtgagagaat gtggatcaga gccatcacct     4980

ccatgccccg tcaccctcta acaaccacat ttacaacttc cccagctctg agacacactt     5040

gcctccaccc cttccatcac cccattttaa gatgaaaata ccacaccagc ctggaaggaa     5100

gaagttactt gcccagggcc acatagtgag ttaagggctg atctagagct aggaagctgt     5160

cttcctgaac cataatcctg gactcttcta acctctctac tcatcgcaaa tagagttcat     5220

tttagtgatt tgaaggaaga tgggacaagt attttcaaac acctgtagga caacatggaa     5280

gtgggaggag acttctactg tagctcccca gagaagagag ctagggctac agagttgcag     5340

ttacaaggtt gccctctctg gcttgatccc caaaggaatt ttctactcca aaatagaatt     5400

tttctaggat gctatttctc agtccctgga gatactcaaa caaagggctt gtcacaaggg     5460

tttttgtaga agctattctt cacagaggtt gggggagaga ttaagccaaa ggatctctga     5520

ggtctttttc aaatctataa ttatgtggcc ttttgttcat tgacttccat gtgttctagt     5580

tgatcattac aaacctggca ggccttctca agggttcagt aattagctgt catttcccat     5640

ttgtccagag agtgtccaac acaaaatacc cctaagatct tggccaatag agaaatgtca     5700

tggaatttta gaaatgacag tatctgcgga gtttattcca agttatatca tttcaaagat     5760

gaagaaaccc aggctcagag ggagccatca catccacacc ctgtcaccct tcgtggccag     5820

tgccagacag tagctagttg gatgctaaaa gtagaattta gatatcttaa caataagccc     5880

agcagtcttt caacttcatt cgtaaatcat ttttgttttg agcatctgtc acgtggcagc     5940

acttgcctgg atactggaga gctgagaagg aatgcgacag gcaagtccta ctctcacagt     6000

gtatacattc aggaggaaca agacacacag tgccaagtaa ataaagtagc tgaacttcat     6060

caaatgattt tattcttaaa gtcattaaag catgtaatgt tccccttttt ttgtttcagg     6120

ggtgtacaga ttgaagaagt gtaggtgttt atgtggtttt agtgacaaac cccatgtgct     6180

ttcattgatt ttatgtttta tgttaaaaca tcaaccgcaa ggtaaaatgc atattgtatg     6240

ttgttggata cgtacttaac tggtatgcat cccatgtctt tgggtactag tgtatgaatt     6300

ctaatctctg taaatgaaat gttgtatgtg ttaatatatt taatagatgt aacttaataa     6360

actggcattg aagactgaag aattttcaca ctgtcaaaaa aaaaaaaaaa aa             6412


<210> 51
<211> 2176
<212> PRT
<213> Homo sapiens

<400> 51
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Thr Ile Pro Ala Pro  Thr Asp Leu 
    1625                 1630                 1635             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1640                 1645                 1650             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1655                 1660                 1665             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1670                 1675                 1680             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1685                 1690                 1695             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1700                 1705                 1710             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1715                 1720                 1725             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1730                 1735                 1740             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1745                 1750                 1755             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1760                 1765                 1770             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1775                 1780                 1785             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1790                 1795                 1800             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1805                 1810                 1815             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1820                 1825                 1830             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1835                 1840                 1845             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1850                 1855                 1860             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1865                 1870                 1875             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1880                 1885                 1890             


Pro Leu  Ile Gly Arg Lys Lys  Thr Gly Gln Glu Ala  Leu Ser Gln 
    1895                 1900                 1905             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    1910                 1915                 1920             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    1925                 1930                 1935             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    1940                 1945                 1950             


Arg Gly  Ala Thr Tyr Asn Ile  Ile Val Glu Ala Leu  Lys Asp Gln 
    1955                 1960                 1965             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    1970                 1975                 1980             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    1985                 1990                 1995             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2000                 2005                 2010             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2015                 2020                 2025             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2030                 2035                 2040             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2045                 2050                 2055             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2060                 2065                 2070             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2075                 2080                 2085             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2090                 2095                 2100             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2105                 2110                 2115             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2120                 2125                 2130             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2135                 2140                 2145             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2150                 2155                 2160             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2165                 2170                 2175     


<210> 52
<211> 7912
<212> DNA
<213> Homo sapiens

<400> 52
gcccgcgccg gctgtgctgc acagggggag gagagggaac cccaggcgcg agcgggaaga       60

ggggacctgc agccacaact tctctggtcc tctgcatccc ttctgtccct ccacccgtcc      120

ccttccccac cctctggccc ccaccttctt ggaggcgaca acccccggga ggcattagaa      180

gggatttttc ccgcaggttg cgaagggaag caaacttggt ggcaacttgc ctcccggtgc      240

gggcgtctct cccccaccgt ctcaacatgc ttaggggtcc ggggcccggg ctgctgctgc      300

tggccgtcca gtgcctgggg acagcggtgc cctccacggg agcctcgaag agcaagaggc      360

aggctcagca aatggttcag ccccagtccc cggtggctgt cagtcaaagc aagcccggtt      420

gttatgacaa tggaaaacac tatcagataa atcaacagtg ggagcggacc tacctaggca      480

atgcgttggt ttgtacttgt tatggaggaa gccgaggttt taactgcgag agtaaacctg      540

aagctgaaga gacttgcttt gacaagtaca ctgggaacac ttaccgagtg ggtgacactt      600

atgagcgtcc taaagactcc atgatctggg actgtacctg catcggggct gggcgaggga      660

gaataagctg taccatcgca aaccgctgcc atgaaggggg tcagtcctac aagattggtg      720

acacctggag gagaccacat gagactggtg gttacatgtt agagtgtgtg tgtcttggta      780

atggaaaagg agaatggacc tgcaagccca tagctgagaa gtgttttgat catgctgctg      840

ggacttccta tgtggtcgga gaaacgtggg agaagcccta ccaaggctgg atgatggtag      900

attgtacttg cctgggagaa ggcagcggac gcatcacttg cacttctaga aatagatgca      960

acgatcagga cacaaggaca tcctatagaa ttggagacac ctggagcaag aaggataatc     1020

gaggaaacct gctccagtgc atctgcacag gcaacggccg aggagagtgg aagtgtgaga     1080

ggcacacctc tgtgcagacc acatcgagcg gatctggccc cttcaccgat gttcgtgcag     1140

ctgtttacca accgcagcct cacccccagc ctcctcccta tggccactgt gtcacagaca     1200

gtggtgtggt ctactctgtg gggatgcagt ggctgaagac acaaggaaat aagcaaatgc     1260

tttgcacgtg cctgggcaac ggagtcagct gccaagagac agctgtaacc cagacttacg     1320

gtggcaactc aaatggagag ccatgtgtct taccattcac ctacaatggc aggacgttct     1380

actcctgcac cacagaaggg cgacaggacg gacatctttg gtgcagcaca acttcgaatt     1440

atgagcagga ccagaaatac tctttctgca cagaccacac tgttttggtt cagactcgag     1500

gaggaaattc caatggtgcc ttgtgccact tccccttcct atacaacaac cacaattaca     1560

ctgattgcac ttctgagggc agaagagaca acatgaagtg gtgtgggacc acacagaact     1620

atgatgccga ccagaagttt gggttctgcc ccatggctgc ccacgaggaa atctgcacaa     1680

ccaatgaagg ggtcatgtac cgcattggag atcagtggga taagcagcat gacatgggtc     1740

acatgatgag gtgcacgtgt gttgggaatg gtcgtgggga atggacatgc attgcctact     1800

cgcagcttcg agatcagtgc attgttgatg acatcactta caatgtgaac gacacattcc     1860

acaagcgtca tgaagagggg cacatgctga actgtacatg cttcggtcag ggtcggggca     1920

ggtggaagtg tgatcccgtc gaccaatgcc aggattcaga gactgggacg ttttatcaaa     1980

ttggagattc atgggagaag tatgtgcatg gtgtcagata ccagtgctac tgctatggcc     2040

gtggcattgg ggagtggcat tgccaacctt tacagaccta tccaagctca agtggtcctg     2100

tcgaagtatt tatcactgag actccgagtc agcccaactc ccaccccatc cagtggaatg     2160

caccacagcc atctcacatt tccaagtaca ttctcaggtg gagacctaaa aattctgtag     2220

gccgttggaa ggaagctacc ataccaggcc acttaaactc ctacaccatc aaaggcctga     2280

agcctggtgt ggtatacgag ggccagctca tcagcatcca gcagtacggc caccaagaag     2340

tgactcgctt tgacttcacc accaccagca ccagcacacc tgtgaccagc aacaccgtga     2400

caggagagac gactcccttt tctcctcttg tggccacttc tgaatctgtg accgaaatca     2460

cagccagtag ctttgtggtc tcctgggtct cagcttccga caccgtgtcg ggattccggg     2520

tggaatatga gctgagtgag gagggagatg agccacagta cctggatctt ccaagcacag     2580

ccacttctgt gaacatccct gacctgcttc ctggccgaaa atacattgta aatgtctatc     2640

agatatctga ggatggggag cagagtttga tcctgtctac ttcacaaaca acagcgcctg     2700

atgcccctcc tgacccgact gtggaccaag ttgatgacac ctcaattgtt gttcgctgga     2760

gcagacccca ggctcccatc acagggtaca gaatagtcta ttcgccatca gtagaaggta     2820

gcagcacaga actcaacctt cctgaaactg caaactccgt caccctcagt gacttgcaac     2880

ctggtgttca gtataacatc actatctatg ctgtggaaga aaatcaagaa agtacacctg     2940

ttgtcattca acaagaaacc actggcaccc cacgctcaga tacagtgccc tctcccaggg     3000

acctgcagtt tgtggaagtg acagacgtga aggtcaccat catgtggaca ccgcctgaga     3060

gtgcagtgac cggctaccgt gtggatgtga tccccgtcaa cctgcctggc gagcacgggc     3120

agaggctgcc catcagcagg aacacctttg cagaagtcac cgggctgtcc cctggggtca     3180

cctattactt caaagtcttt gcagtgagcc atgggaggga gagcaagcct ctgactgctc     3240

aacagacaac caaactggat gctcccacta acctccagtt tgtcaatgaa actgattcta     3300

ctgtcctggt gagatggact ccacctcggg cccagataac aggataccga ctgaccgtgg     3360

gccttacccg aagaggacag cccaggcagt acaatgtggg tccctctgtc tccaagtacc     3420

cactgaggaa tctgcagcct gcatctgagt acaccgtatc cctcgtggcc ataaagggca     3480

accaagagag ccccaaagcc actggagtct ttaccacact gcagcctggg agctctattc     3540

caccttacaa caccgaggtg actgagacca ccattgtgat cacatggacg cctgctccaa     3600

gaattggttt taagctgggt gtacgaccaa gccagggagg agaggcacca cgagaagtga     3660

cttcagactc aggaagcatc gttgtgtccg gcttgactcc aggagtagaa tacgtctaca     3720

ccatccaagt cctgagagat ggacaggaaa gagatgcgcc aattgtaaac aaagtggtga     3780

caccattgtc tccaccaaca aacttgcatc tggaggcaaa ccctgacact ggagtgctca     3840

cagtctcctg ggagaggagc accaccccag acattactgg ttatagaatt accacaaccc     3900

ctacaaacgg ccagcaggga aattctttgg aagaagtggt ccatgctgat cagagctcct     3960

gcacttttga taacctgagt cccggcctgg agtacaatgt cagtgtttac actgtcaagg     4020

atgacaagga aagtgtccct atctctgata ccatcatccc agctgttcct cctcccactg     4080

acctgcgatt caccaacatt ggtccagaca ccatgcgtgt cacctgggct ccacccccat     4140

ccattgattt aaccaacttc ctggtgcgtt actcacctgt gaaaaatgag gaagatgttg     4200

cagagttgtc aatttctcct tcagacaatg cagtggtctt aacaaatctc ctgcctggta     4260

cagaatatgt agtgagtgtc tccagtgtct acgaacaaca tgagagcaca cctcttagag     4320

gaagacagaa aacaggtctt gattccccaa ctggcattga cttttctgat attactgcca     4380

actcttttac tgtgcactgg attgctcctc gagccaccat cactggctac aggatccgcc     4440

atcatcccga gcacttcagt gggagacctc gagaagatcg ggtgccccac tctcggaatt     4500

ccatcaccct caccaacctc actccaggca cagagtatgt ggtcagcatc gttgctctta     4560

atggcagaga ggaaagtccc ttattgattg gccaacaatc aacagtttct gatgttccga     4620

gggacctgga agttgttgct gcgaccccca ccagcctact gatcagctgg gatgctcctg     4680

ctgtcacagt gagatattac aggatcactt acggagagac aggaggaaat agccctgtcc     4740

aggagttcac tgtgcctggg agcaagtcta cagctaccat cagcggcctt aaacctggag     4800

ttgattatac catcactgtg tatgctgtca ctggccgtgg agacagcccc gcaagcagca     4860

agccaatttc cattaattac cgaacagaaa ttgacaaacc atcccagatg caagtgaccg     4920

atgttcagga caacagcatt agtgtcaagt ggctgccttc aagttcccct gttactggtt     4980

acagagtaac caccactccc aaaaatggac caggaccaac aaaaactaaa actgcaggtc     5040

cagatcaaac agaaatgact attgaaggct tgcagcccac agtggagtat gtggttagtg     5100

tctatgctca gaatccaagc ggagagagtc agcctctggt tcagactgca gtaaccacta     5160

ttcctgcacc aactgacctg aagttcactc aggtcacacc cacaagcctg agcgcccagt     5220

ggacaccacc caatgttcag ctcactggat atcgagtgcg ggtgaccccc aaggagaaga     5280

ccggaccaat gaaagaaatc aaccttgctc ctgacagctc atccgtggtt gtatcaggac     5340

ttatggtggc caccaaatat gaagtgagtg tctatgctct taaggacact ttgacaagca     5400

gaccagctca gggagttgtc accactctgg agaatgtcag cccaccaaga agggctcgtg     5460

tgacagatgc tactgagacc accatcacca ttagctggag aaccaagact gagacgatca     5520

ctggcttcca agttgatgcc gttccagcca atggccagac tccaatccag agaaccatca     5580

agccagatgt cagaagctac accatcacag gtttacaacc aggcactgac tacaagatct     5640

acctgtacac cttgaatgac aatgctcgga gctcccctgt ggtcatcgac gcctccactg     5700

ccattgatgc accatccaac ctgcgtttcc tggccaccac acccaattcc ttgctggtat     5760

catggcagcc gccacgtgcc aggattaccg gctacatcat caagtatgag aagcctgggt     5820

ctcctcccag agaagtggtc cctcggcccc gccctggtgt cacagaggct actattactg     5880

gcctggaacc gggaaccgaa tatacaattt atgtcattgc cctgaagaat aatcagaaga     5940

gcgagcccct gattggaagg aaaaagacag gacaagaagc tctctctcag acaaccatct     6000

catgggcccc attccaggac acttctgagt acatcatttc atgtcatcct gttggcactg     6060

atgaagaacc cttacagttc agggttcctg gaacttctac cagtgccact ctgacaggcc     6120

tcaccagagg tgccacctac aacatcatag tggaggcact gaaagaccag cagaggcata     6180

aggttcggga agaggttgtt accgtgggca actctgtcaa cgaaggcttg aaccaaccta     6240

cggatgactc gtgctttgac ccctacacag tttcccatta tgccgttgga gatgagtggg     6300

aacgaatgtc tgaatcaggc tttaaactgt tgtgccagtg cttaggcttt ggaagtggtc     6360

atttcagatg tgattcatct agatggtgcc atgacaatgg tgtgaactac aagattggag     6420

agaagtggga ccgtcaggga gaaaatggcc agatgatgag ctgcacatgt cttgggaacg     6480

gaaaaggaga attcaagtgt gaccctcatg aggcaacgtg ttatgatgat gggaagacat     6540

accacgtagg agaacagtgg cagaaggaat atctcggtgc catttgctcc tgcacatgct     6600

ttggaggcca gcggggctgg cgctgtgaca actgccgcag acctgggggt gaacccagtc     6660

ccgaaggcac tactggccag tcctacaacc agtattctca gagataccat cagagaacaa     6720

acactaatgt taattgccca attgagtgct tcatgccttt agatgtacag gctgacagag     6780

aagattcccg agagtaaatc atctttccaa tccagaggaa caagcatgtc tctctgccaa     6840

gatccatcta aactggagtg atgttagcag acccagctta gagttcttct ttctttctta     6900

agccctttgc tctggaggaa gttctccagc ttcagctcaa ctcacagctt ctccaagcat     6960

caccctggga gtttcctgag ggttttctca taaatgaggg ctgcacattg cctgttctgc     7020

ttcgaagtat tcaataccgc tcagtatttt aaatgaagtg attctaagat ttggtttggg     7080

atcaatagga aagcatatgc agccaaccaa gatgcaaatg ttttgaaatg atatgaccaa     7140

aattttaagt aggaaagtca cccaaacact tctgctttca cttaagtgtc tggcccgcaa     7200

tactgtagga acaagcatga tcttgttact gtgatatttt aaatatccac agtactcact     7260

ttttccaaat gatcctagta attgcctaga aatatctttc tcttacctgt tatttatcaa     7320

tttttcccag tatttttata cggaaaaaat tgtattgaaa acacttagta tgcagttgat     7380

aagaggaatt tggtataatt atggtgggtg attatttttt atactgtatg tgccaaagct     7440

ttactactgt ggaaagacaa ctgttttaat aaaagattta cattccacaa cttgaagttc     7500

atctatttga tataagacac cttcggggga aataattcct gtgaatattc tttttcaatt     7560

cagcaaacat ttgaaaatct atgatgtgca agtctaattg ttgatttcag tacaagattt     7620

tctaaatcag ttgctacaaa aactgattgg tttttgtcac ttcatctctt cactaatgga     7680

gatagcttta cactttctgc tttaatagat ttaagtggac cccaatattt attaaaattg     7740

ctagtttacc gttcagaagt ataatagaaa taatctttag ttgctctttt ctaaccattg     7800

taattcttcc cttcttccct ccacctttcc ttcattgaat aaacctctgt tcaaagagat     7860

tgcctgcaag ggaaataaaa atgactaaga tattaaaaaa aaaaaaaaaa aa             7912


<210> 53
<211> 175
<212> PRT
<213> Homo sapiens

<400> 53
Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu 
145                 150                 155                 160 


Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu 
                165                 170                 175 


<210> 54
<211> 996
<212> DNA
<213> Homo sapiens

<400> 54
aatcacttgg ggaaaggaag gttcgtttct gagttagcaa caagtaaatg cagcactagt       60

gggtgggatt gaggtatgcc ctggtgcata aatagagact cagctgtgct ggcacactca      120

gaagcttgga ccgcatccta gccgccgact cacacaaggc aggtgggtga ggaaatccag      180

agttgccatg gagaaaattc cagtgtcagc attcttgctc cttgtggccc tctcctacac      240

tctggccaga gataccacag tcaaacctgg agccaaaaag gacacaaagg actctcgacc      300

caaactgccc cagaccctct ccagaggttg gggtgaccaa ctcatctgga ctcagacata      360

tgaagaagct ctatataaat ccaagacaag caacaaaccc ttgatgatta ttcatcactt      420

ggatgagtgc ccacacagtc aagctttaaa gaaagtgttt gctgaaaata aagaaatcca      480

gaaattggca gagcagtttg tcctcctcaa tctggtttat gaaacaactg acaaacacct      540

ttctcctgat ggccagtatg tccccaggat tatgtttgtt gacccatctc tgacagttag      600

agccgatatc actggaagat attcaaatcg tctctatgct tacgaacctg cagatacagc      660

tctgttgctt gacaacatga agaaagctct caagttgctg aagactgaat tgtaaagaaa      720

aaaaatctcc aagcccttct gtctgtcagg ccttgagact tgaaaccaga agaagtgtga      780

gaagactggc tagtgtggaa gcatagtgaa cacactgatt aggttatggt ttaatgttac      840

aacaactatt ttttaagaaa aacaagtttt agaaatttgg tttcaagtgt acatgtgtga      900

aaacaatatt gtatactacc atagtgagcc atgattttct aaaaaaaaaa ataaatgttt      960

tgggggtgtt ctgttttctc caaaaaaaaa aaaaaa                                996


<210> 55
<211> 313
<212> PRT
<213> Homo sapiens

<400> 55
Met Asn Gln Leu Ser Phe Leu Leu Phe Leu Ile Ala Thr Thr Arg Gly 
1               5                   10                  15      


Trp Ser Thr Asp Glu Ala Asn Thr Tyr Phe Lys Glu Trp Thr Cys Ser 
            20                  25                  30          


Ser Ser Pro Ser Leu Pro Arg Ser Cys Lys Glu Ile Lys Asp Glu Cys 
        35                  40                  45              


Pro Ser Ala Phe Asp Gly Leu Tyr Phe Leu Arg Thr Glu Asn Gly Val 
    50                  55                  60                  


Ile Tyr Gln Thr Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr 
65                  70                  75                  80  


Leu Val Ala Ser Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val 
                85                  90                  95      


Gly Asp Arg Trp Ser Ser Gln Gln Gly Ser Lys Ala Val Tyr Pro Glu 
            100                 105                 110         


Gly Asp Gly Asn Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala 
        115                 120                 125             


Ala Thr Ser Asp Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala 
    130                 135                 140                 


Lys Asp Leu Gly Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His 
145                 150                 155                 160 


Trp Arg Asn Ser Ser Leu Leu Arg Tyr Arg Thr Asp Thr Gly Phe Leu 
                165                 170                 175     


Gln Thr Leu Gly His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val 
            180                 185                 190         


Lys Tyr Gly Glu Gly Lys Cys Trp Thr Asp Asn Gly Pro Val Ile Pro 
        195                 200                 205             


Val Val Tyr Asp Phe Gly Asp Ala Gln Lys Thr Ala Ser Tyr Tyr Ser 
    210                 215                 220                 


Pro Tyr Gly Gln Arg Glu Phe Thr Ala Gly Phe Val Gln Phe Arg Val 
225                 230                 235                 240 


Phe Asn Asn Glu Arg Ala Ala Asn Ala Leu Cys Ala Gly Met Arg Val 
                245                 250                 255     


Thr Gly Cys Asn Thr Glu His His Cys Ile Gly Gly Gly Gly Tyr Phe 
            260                 265                 270         


Pro Glu Ala Ser Pro Gln Gln Cys Gly Asp Phe Ser Gly Phe Asp Trp 
        275                 280                 285             


Ser Gly Tyr Gly Thr His Val Gly Tyr Ser Ser Ser Arg Glu Ile Thr 
    290                 295                 300                 


Glu Ala Ala Val Leu Leu Phe Tyr Arg 
305                 310             


<210> 56
<211> 985
<212> DNA
<213> Homo sapiens

<400> 56
gtacaaaaaa gcaggctcca ccatgaacca actcagcttc ctgctgtttc tcatagcgac       60

caccagagga tggagtacag atgaggctaa tacttacttc aaggaatgga cctgttcttc      120

gtctccatct ctgcccagaa gctgcaagga aatcaaagac gaatgtccta gtgcatttga      180

tggcctgtat tttctccgca ctgagaatgg tgttatctac cagaccttct gtgacatgac      240

ctctgggggt ggcggctgga ccctggtggc cagcgtgcac gagaatgaca tgcgtgggaa      300

gtgcacggtg ggcgatcgct ggtccagtca gcagggcagc aaagcagtct acccagaggg      360

ggacggcaac tgggccaact acaacacctt tggatctgca gaggcggcca cgagcgatga      420

ctacaagaac cctggctact acgacatcca ggccaaggac ctgggcatct ggcacgtgcc      480

caataagtcc cccatgcagc actggagaaa cagctccctg ctgaggtacc gcacggacac      540

tggcttcctc cagacactgg gacataatct gtttggcatc taccagaaat atccagtgaa      600

atatggagaa ggaaagtgtt ggactgacaa cggcccggtg atccctgtgg tctatgattt      660

tggcgacgcc cagaaaacag catcttatta ctcaccctat ggccagcggg aattcactgc      720

gggatttgtt cagttcaggg tatttaataa cgagagagca gccaacgcct tgtgtgctgg      780

aatgagggtc accggatgta acactgagca ccactgcatt ggtggaggag gatactttcc      840

agaggccagt ccccagcagt gtggagattt ttctggtttt gattggagtg gatatggaac      900

tcatgttggt tacagcagca gccgtgagat aactgaggca gctgtgcttc tattctatcg      960

ttgaatccac ccagctttct tgtac                                            985


