                         SEQUENCE LISTING

<110>  Tan, Philip
       Blankenship, John
 
<120>  MULTISPECIFIC ANTI-CD37 ANTIBODIES AND RELATED COMPOSITIONS AND 
       METHODS

<130>  EMER-019/00US
<140>  US 61/792,474
<141>  2013-03-15

<160>  180   

<170>  PatentIn version 3.5

<210>  1
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRU-016 full length sequence

<400>  1

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Arg Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
                85                  90                  95      


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
                165                 170                 175     


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser 
            180                 185                 190         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        195                 200                 205             


Ile Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro 
                245                 250                 255     


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Asp Gln Glu 
            260                 265                 270         


Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys 
            500             


<210>  2
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRU-016 binding domain TRU-016

<400>  2
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt       60

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      120

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      180

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      240

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      300

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      360

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      420

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      480

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      540

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      600

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      660

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      720

caagggacca aggtggaaat caaa                                             744


<210>  3
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRU-016 binding domain

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr 
    210 


<210>  4
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRU-016 variable heavy domain

<400>  4
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt       60

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      120

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      180

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      240

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      300

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctct                   348


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRU-016 variable heavy domain

<400>  5

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  6
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRU-016 variable light domain

<400>  6
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccaggcga aagagccacc       60

ctctcctgcc gagcaagtga aaatgtttac agctacttag cctggtacca acagaaacct      120

ggccaggctc ctaggctcct catctatttt gcaaaaacct tagcagaagg tattccagcc      180

aggttcagtg gcagtggctc cgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcaacat cattccgata atccgtggac attcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  7
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRU-016 variable light domain

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Phe Ala Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Asp Gln 
            100                 105                 110 


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  8

Gly Tyr Ser Phe Thr Gly Tyr Asn 
1               5               


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  9

Gly Tyr Met Met Asn 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  10

Gly Tyr Asn Met Asn 
1               5   


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  11

Ile Asp Pro Tyr Tyr Gly Gly Thr 
1               5               


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  12

Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys 
1               5                   10                  15      


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  13

Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg 
1               5                   10              


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  14

Ala Arg Ser Val Gly Pro Phe Asp Ser 
1               5                   


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  15

Ser Val Gly Pro Phe Asp Tyr 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  16

Ser Val Gly Pro Phe Asp Ser 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  17

Ser Val Gly Pro Met Asp Tyr 
1               5           


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  18

Glu Asn Val Tyr Ser Tyr 
1               5       


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  19

Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  20

Arg Thr Ser Glu Asn Val Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  21

Gly Tyr Met Met Asn 
1               5   


<210>  22
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  22

Phe Ala Lys 
1           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  23

Phe Ala Lys Thr Leu Ala Glu 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  24

Gln His His Ser Asp Asn Pro Trp Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  25

Gln His His Ser Asp Asn Pro Trp Thr 
1               5                   


<210>  26
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable heavy domain

<400>  26
gcggtccagc tgcagcagtc tggacctgag ctggaaaagc ctggcgcttc agtgaagatt       60

tcctgcaagg cttctggtta ctcattcact ggctacaata tgaactgggt gaagcagaat      120

aatggaaaga gccttgagtg gattggaaat attgatcctt attatggtgg tactacctac      180

aaccggaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca agagtctgac atctgaggac tctgcagtct attactgtgc aagatcggtc      300

ggccctatgg actactgggg tcaaggaacc tcagtcaccg tctcttct                   348


<210>  27
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy domain

<400>  27

Ala Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  28
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  28
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga gactgtcacc       60

atcacatgtc gaacaagtga aaatgtttac agttatttgg cttggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctctttt gcaaaaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcagcag cctgcagcct      240

gaagattctg gaagttattt ctgtcaacat cattccgata atccgtggac gttcggtgga      300

ggcaccgaac tggagatcaa acga                                             324


<210>  29
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light domain

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Ser Phe Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Gly Ser Tyr Phe Cys Gln His His Ser Asp Asn Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Arg 
            100                 105             


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  30

Thr Ser Gly Val Ser 
1               5   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  31

Val Ile Trp Gly Asp Gly Ser Thr Asn 
1               5                   


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  32

Gly Gly Tyr Ser Leu Ala His 
1               5           


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  33

Arg Ala Ser Glu Asn Ile Arg Ser Asn Leu Ala 
1               5                   10      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  34

Val Ala Thr Asn Leu Ala Asp 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  35

Gln His Tyr Trp Gly Thr Thr Trp Thr 
1               5                   


<210>  36
<211>  431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variable heavy chain huCD37-3v1.0

<400>  36
aagcttgcca ccatgggttg gagctgcatt attctgtttc tggtggccac cgccaccggt       60

gtgcactcac aagtccaagt ccaagaatct ggtccaggtc tggtggcccc ttcccaaact      120

ctgagcatca cctgtaccgt ttctggtttt agccttacca cctctggtgt gagttgggta      180

cgccaaccac ccggtaaggg tctcgaatgg ctgggtgtaa tctggggtga tggttccaca      240

aattaccatc cttccctcaa gtcccgcctt agcatcaaaa aggatcacag caaaagtcaa      300

gttttcctga aactgaatag tctgacagca gccgatacag ccacctacta ttgcgccaag      360

ggtggttata gtcttgcaca ctggggtcaa ggtaccctcg ttaccgtctc ctcagctagt      420

accaagggcc c                                                           431


<210>  37
<211>  431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variable heavy chain huCD37-3v1.1

<400>  37
aagcttgcca ccatgggctg gagctgtatc attctgtttc tggtggcgac agctactggg       60

gtccactccc aagtgcaggt acaagagtcc gggcctggat tggtcgcacc aagccagacc      120

ctctctatca cttgtaccgt tagcgggttc tctctgacaa ccagtggagt gagttgggtg      180

aggcagccac caggaaaggg actggagtgg ctgggggtga tttggggcga cggcagcaca      240

aactatcatt ccagtcttaa atctcggttg tccattaaaa aagaccatag taaatctcaa      300

gttttcctga aactcaatag cctgacagcc gcagacactg ctacgtatta ctgcgccaaa      360

ggaggataca gtctggctca ctggggacag gggaccctgg tgaccgtgtc atccgcatca      420

acaaagggcc c                                                           431


<210>  38
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain huCD37-3v1.0

<400>  38

Gln Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  39
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain huCD37-3v1.1

<400>  39

Gln Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full heavy chain huCD37-3v1.0

<400>  40

Gln Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Leu Tyr Thr His Arg Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  41
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full heavy chain huCD37-3v1.1

<400>  41

Gln Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  42
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variable light domain huCD37-3

<400>  42
gaattcgcca ccatgggttg gtcctgcatc atcttgtttc tcgtggccac agccaccggt       60

gttcactctg atatacaaat gactcaaagc ccttccagtt tgagcgtaag tgtgggtgaa      120

cgcgtaacaa tcacctgtag agctagtgaa aacatccgca gtaatctcgc atggtaccaa      180

caaaagccag gtaagtcacc taagctcctc gtgaatgttg ctaccaacct cgctgatggt      240

gtgccttcac gattctctgg ttcaggttcc ggtaccgatt attcacttaa gatcaactca      300

ctccaaccag aagatttcgg tacatattac tgtcaacact actggggtac gacctggaca      360

ttcggtcaag gtactaagct ggaaatcaag cgtacg                                396


<210>  43
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain huCD37-3

<400>  43

Gln Val Gln Val Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  44
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full light chain huCD37-3

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Asn Val Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Trp Gly Thr Thr Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  45
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAS105 bispecific antibody

<400>  45
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtcaga ggcacaacaa ttcttccctg aatacaggaa ctcagatggc aggtcattct     1560

ccgaattctc aggtccagct ggtggagtct gggggcggag tggtgcagcc tgggcggtca     1620

ctgaggctgt cctgcaaggc ttctggctac acctttacta gatctacgat gcactgggta     1680

aggcaggccc ctggacaagg tctggaatgg attggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacagg ttcacaatca gcgcagacaa atccaagagc     1800

acagccttcc tgcagatgga cagcctgagg cccgaggaca ccggcgtcta tttctgtgca     1860

cggccccaag tccactatga ttacaacggg tttccttact ggggccaagg gactcccgtc     1920

actgtctcta gcggtggcgg agggtctggg ggtggcggat ccggaggtgg tggctctgca     1980

caagacatcc agatgaccca gtctccaagc agcctgtctg caagcgtggg ggacagggtc     2040

accatgacct gcagtgccag ctcaagtgta agttacatga actggtacca gcagaagccg     2100

ggcaaggccc ccaaaagatg gatttatgac tcatccaaac tggcttctgg agtccctgct     2160

cgcttcagtg gcagtgggtc tgggaccgac tataccctca caatcagcag cctgcagccc     2220

gaagatttcg ccacttatta ctgccagcag tggagtcgta acccacccac gttcggaggg     2280

gggaccaagc tacaaattac atcctccagc taa                                  2313


<210>  46
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS105 bispecific antibody

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
                485                 490                 495     


Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
            500                 505                 510         


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp 
                565                 570                 575     


Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
            580                 585                 590         


Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
625                 630                 635                 640 


Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745                 750 


<210>  47
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAS106 bispecific antibody

<400>  47
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcaggtgctc cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      960

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagttcgcca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1140

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaggctaac cgtggacaag agccggtggc aggaggggaa tgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     1500

ccgggtcaga ggcacaacaa ttcttccctg aatacaggaa ctcagatggc aggtcattct     1560

ccgaattctc aggtccagct ggtggagtct gggggcggag tggtgcagcc tgggcggtca     1620

ctgaggctgt cctgcaaggc ttctggctac acctttacta gatctacgat gcactgggta     1680

aggcaggccc ctggacaagg tctggaatgg attggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacagg ttcacaatca gcgcagacaa atccaagagc     1800

acagccttcc tgcagatgga cagcctgagg cccgaggaca ccggcgtcta tttctgtgca     1860

cggccccaag tccactatga ttacaacggg tttccttact ggggccaagg gactcccgtc     1920

actgtctcta gcggtggcgg agggtctggg ggtggcggat ccggaggtgg tggctctgca     1980

caagacatcc agatgaccca gtctccaagc agcctgtctg caagcgtggg ggacagggtc     2040

accatgacct gcagtgccag ctcaagtgta agttacatga actggtacca gcagaagccg     2100

ggcaaggccc ccaaaagatg gatttatgac tcatccaaac tggcttctgg agtccctgct     2160

cgcttcagtg gcagtgggtc tgggaccgac tataccctca caatcagcag cctgcagccc     2220

gaagatttcg ccacttatta ctgccagcag tggagtcgta acccacccac gttcggaggg     2280

gggaccaagc tacaaattac atcctccagc taa                                  2313


<210>  48
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS106 bispecific antibody

<400>  48

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
                485                 490                 495     


Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
            500                 505                 510         


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp 
                565                 570                 575     


Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
            580                 585                 590         


Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
625                 630                 635                 640 


Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745                 750 


<210>  49
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAS107 bispecific antibody

<400>  49
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgaattct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag ctaa                                            2304


<210>  50
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS107 bispecific antibody

<400>  50

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            500                 505                 510         


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
                565                 570                 575     


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
            580                 585                 590         


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile 
625                 630                 635                 640 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                645                 650                 655     


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            660                 665                 670         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser 
        675                 680                 685             


Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    690                 695                 700                 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
705                 710                 715                 720 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly 
                725                 730                 735     


Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745         


<210>  51
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAS108 bispecific antibody

<400>  51
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggttctt ccctgaatac aggaactcag ccgaattctc aggtccagct ggtggagtct     1560

gggggcggag tggtgcagcc tgggcggtca ctgaggctgt cctgcaaggc ttctggctac     1620

acctttacta gatctacgat gcactgggta aggcaggccc ctggacaagg tctggaatgg     1680

attggataca ttaatcctag cagtgcttat actaattaca atcagaaatt caaggacagg     1740

ttcacaatca gcgcagacaa atccaagagc acagccttcc tgcagatgga cagcctgagg     1800

cccgaggaca ccggcgtcta tttctgtgca cggccccaag tccactatga ttacaacggg     1860

tttccttact ggggccaagg gactcccgtc actgtctcta gcggtggcgg agggtctggg     1920

ggtggcggat ccggaggtgg tggctctgca caagacatcc agatgaccca gtctccaagc     1980

agcctgtctg caagcgtggg ggacagggtc accatgacct gcagtgccag ctcaagtgta     2040

agttacatga actggtacca gcagaagccg ggcaaggccc ccaaaagatg gatttatgac     2100

tcatccaaac tggcttctgg agtccctgct cgcttcagtg gcagtgggtc tgggaccgac     2160

tataccctca caatcagcag cctgcagccc gaagatttcg ccacttatta ctgccagcag     2220

tggagtcgta acccacccac gttcggaggg gggaccaagc tacaaattac atcctccagc     2280

taa                                                                   2283


<210>  52
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS108 bispecific antibody

<400>  52

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Leu Asn Thr Gly Thr Gln Pro Asn Ser Gln Val Gln 
                485                 490                 495     


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            500                 505                 510         


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
    530                 535                 540                 


Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg 
545                 550                 555                 560 


Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met 
                565                 570                 575     


Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro 
            580                 585                 590         


Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
        595                 600                 605             


Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala 
                645                 650                 655     


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
            660                 665                 670         


Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val 
        675                 680                 685             


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
    690                 695                 700                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
705                 710                 715                 720 


Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile 
                725                 730                 735     


Thr Ser Ser Ser 
            740 


<210>  53
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAS109 bispecific antibody

<400>  53
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcaggtgctc cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      960

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagttcgcca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1140

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaggctaac cgtggacaag agccggtggc aggaggggaa tgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     1500

ccgggtggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgaattct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag ctaa                                            2304


<210>  54
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS109 bispecific antibody

<400>  54

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            500                 505                 510         


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
                565                 570                 575     


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
            580                 585                 590         


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile 
625                 630                 635                 640 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                645                 650                 655     


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            660                 665                 670         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser 
        675                 680                 685             


Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    690                 695                 700                 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
705                 710                 715                 720 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly 
                725                 730                 735     


Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745         


<210>  55
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAS110 bispecific antibody

<400>  55
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcaggtgctc cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      960

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagttcgcca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1140

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaggctaac cgtggacaag agccggtggc aggaggggaa tgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     1500

ccgggttctt ccctgaatac aggaactcag ccgaattctc aggtccagct ggtggagtct     1560

gggggcggag tggtgcagcc tgggcggtca ctgaggctgt cctgcaaggc ttctggctac     1620

acctttacta gatctacgat gcactgggta aggcaggccc ctggacaagg tctggaatgg     1680

attggataca ttaatcctag cagtgcttat actaattaca atcagaaatt caaggacagg     1740

ttcacaatca gcgcagacaa atccaagagc acagccttcc tgcagatgga cagcctgagg     1800

cccgaggaca ccggcgtcta tttctgtgca cggccccaag tccactatga ttacaacggg     1860

tttccttact ggggccaagg gactcccgtc actgtctcta gcggtggcgg agggtctggg     1920

ggtggcggat ccggaggtgg tggctctgca caagacatcc agatgaccca gtctccaagc     1980

agcctgtctg caagcgtggg ggacagggtc accatgacct gcagtgccag ctcaagtgta     2040

agttacatga actggtacca gcagaagccg ggcaaggccc ccaaaagatg gatttatgac     2100

tcatccaaac tggcttctgg agtccctgct cgcttcagtg gcagtgggtc tgggaccgac     2160

tataccctca caatcagcag cctgcagccc gaagatttcg ccacttatta ctgccagcag     2220

tggagtcgta acccacccac gttcggaggg gggaccaagc tacaaattac atcctccagc     2280

taa                                                                   2283


<210>  56
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS110 bispecific antibody

<400>  56

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Leu Asn Thr Gly Thr Gln Pro Asn Ser Gln Val Gln 
                485                 490                 495     


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            500                 505                 510         


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
    530                 535                 540                 


Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg 
545                 550                 555                 560 


Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met 
                565                 570                 575     


Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro 
            580                 585                 590         


Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
        595                 600                 605             


Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala 
                645                 650                 655     


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
            660                 665                 670         


Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val 
        675                 680                 685             


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
    690                 695                 700                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
705                 710                 715                 720 


Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile 
                725                 730                 735     


Thr Ser Ser Ser 
            740 


<210>  57
<211>  2292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAS111 bispecific antibody

<400>  57
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtgaag ttcaaattcc cttgaccgaa agttacagcc cgaattctca ggtccagctg     1560

gtggagtctg ggggcggagt ggtgcagcct gggcggtcac tgaggctgtc ctgcaaggct     1620

tctggctaca cctttactag atctacgatg cactgggtaa ggcaggcccc tggacaaggt     1680

ctggaatgga ttggatacat taatcctagc agtgcttata ctaattacaa tcagaaattc     1740

aaggacaggt tcacaatcag cgcagacaaa tccaagagca cagccttcct gcagatggac     1800

agcctgaggc ccgaggacac cggcgtctat ttctgtgcac ggccccaagt ccactatgat     1860

tacaacgggt ttccttactg gggccaaggg actcccgtca ctgtctctag cggtggcgga     1920

gggtctgggg gtggcggatc cggaggtggt ggctctgcac aagacatcca gatgacccag     1980

tctccaagca gcctgtctgc aagcgtgggg gacagggtca ccatgacctg cagtgccagc     2040

tcaagtgtaa gttacatgaa ctggtaccag cagaagccgg gcaaggcccc caaaagatgg     2100

atttatgact catccaaact ggcttctgga gtccctgctc gcttcagtgg cagtgggtct     2160

gggaccgact ataccctcac aatcagcagc ctgcagcccg aagatttcgc cacttattac     2220

tgccagcagt ggagtcgtaa cccacccacg ttcggagggg ggaccaagct acaaattaca     2280

tcctccagct aa                                                         2292


<210>  58
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS111 bispecific antibody

<400>  58

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
                485                 490                 495     


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
            500                 505                 510         


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
        515                 520                 525             


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
    530                 535                 540                 


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
545                 550                 555                 560 


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
                565                 570                 575     


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
            580                 585                 590         


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
        595                 600                 605             


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
625                 630                 635                 640 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
                645                 650                 655     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
            660                 665                 670         


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
        675                 680                 685             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
    690                 695                 700                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
705                 710                 715                 720 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                725                 730                 735     


Leu Gln Ile Thr Ser Ser Ser 
            740             


<210>  59
<211>  2292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAS112 bispecific antibody

<400>  59
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcaggtgctc cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      960

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagttcgcca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1140

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaggctaac cgtggacaag agccggtggc aggaggggaa tgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     1500

ccgggtgaag ttcaaattcc cttgaccgaa agttacagcc cgaattctca ggtccagctg     1560

gtggagtctg ggggcggagt ggtgcagcct gggcggtcac tgaggctgtc ctgcaaggct     1620

tctggctaca cctttactag atctacgatg cactgggtaa ggcaggcccc tggacaaggt     1680

ctggaatgga ttggatacat taatcctagc agtgcttata ctaattacaa tcagaaattc     1740

aaggacaggt tcacaatcag cgcagacaaa tccaagagca cagccttcct gcagatggac     1800

agcctgaggc ccgaggacac cggcgtctat ttctgtgcac ggccccaagt ccactatgat     1860

tacaacgggt ttccttactg gggccaaggg actcccgtca ctgtctctag cggtggcgga     1920

gggtctgggg gtggcggatc cggaggtggt ggctctgcac aagacatcca gatgacccag     1980

tctccaagca gcctgtctgc aagcgtgggg gacagggtca ccatgacctg cagtgccagc     2040

tcaagtgtaa gttacatgaa ctggtaccag cagaagccgg gcaaggcccc caaaagatgg     2100

atttatgact catccaaact ggcttctgga gtccctgctc gcttcagtgg cagtgggtct     2160

gggaccgact ataccctcac aatcagcagc ctgcagcccg aagatttcgc cacttattac     2220

tgccagcagt ggagtcgtaa cccacccacg ttcggagggg ggaccaagct acaaattaca     2280

tcctccagct aa                                                         2292


<210>  60
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS112 bispecific antibody

<400>  60

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
                485                 490                 495     


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
            500                 505                 510         


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
        515                 520                 525             


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
    530                 535                 540                 


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
545                 550                 555                 560 


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
                565                 570                 575     


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
            580                 585                 590         


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
        595                 600                 605             


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
625                 630                 635                 640 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
                645                 650                 655     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
            660                 665                 670         


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
        675                 680                 685             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
    690                 695                 700                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
705                 710                 715                 720 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                725                 730                 735     


Leu Gln Ile Thr Ser Ser Ser 
            740             


<210>  61
<211>  280
<212>  PRT
<213>  Homo sapiens  

<400>  61

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Tyr Arg 
        275                 280 


<210>  62
<211>  2471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG100 bispecific antibody

<400>  62
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aagcttgcca ccatgggttg gagctgcatt attctgtttc tggtggccac cgccaccggt      120

gtgcactcac aagtccaagt ccaagaatct ggtccaggtc tggtggcccc ttcccaaact      180

ctgagcatca cctgtaccgt ttctggtttt agccttacca cctctggtgt gagttgggta      240

cgccaaccac ccggtaaggg tctcgaatgg ctgggtgtaa tctggggtga tggttccaca      300

aattaccatc cttccctcaa gtcccgcctt agcatcaaaa aggatcacag caaaagtcaa      360

gttttcctga aactgaatag tctgacagca gccgatacag ccacctacta ttgcgccaag      420

ggtggttata gtcttgcaca ctggggtcaa ggtaccctcg ttaccgtctc ctcagctagt      480

accaagggcc cgggggtgga ggctctggtg gcggtggctc tggcggaggt ggatccggtg      540

gcggcggatc tggcgggggt ggctctgaat tcgccaccat gggttggtcc tgcatcatct      600

tgtttctcgt ggccacagcc accggtgttc actctgatat acaaatgact caaagccctt      660

ccagtttgag cgtaagtgtg ggtgaacgcg taacaatcac ctgtagagct agtgaaaaca      720

tccgcagtaa tctcgcatgg taccaacaaa agccaggtaa gtcacctaag ctcctcgtga      780

atgttgctac caacctcgct gatggtgtgc cttcacgatt ctctggttca ggttccggta      840

ccgattattc acttaagatc aactcactcc aaccagaaga tttcggtaca tattactgtc      900

aacactactg gggtacgacc tggacattcg gtcaaggtac taagctggaa atcaagcgta      960

cgtcctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg tgcccagcac     1020

ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag gacaccctca     1080

tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac gaagaccctg     1140

aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag acaaagccgc     1200

gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg     1260

actggctgaa tggcaaggca tacgcgtgcg cggtctccaa caaagccctc ccagccccca     1320

tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg tacaccctgc     1380

ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg gtcaaaggct     1440

tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag aacaactaca     1500

agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc aagctcaccg     1560

tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg catgaggctc     1620

tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtcagagg cacaacaatt     1680

cttccctgaa tacaggaact cagatggcag gtcattctcc gaattctcag gtccagctgg     1740

tggagtctgg gggcggagtg gtgcagcctg ggcggtcact gaggctgtcc tgcaaggctt     1800

ctggctacac ctttactaga tctacgatgc actgggtaag gcaggcccct ggacaaggtc     1860

tggaatggat tggatacatt aatcctagca gtgcttatac taattacaat cagaaattca     1920

aggacaggtt cacaatcagc gcagacaaat ccaagagcac agccttcctg cagatggaca     1980

gcctgaggcc cgaggacacc ggcgtctatt tctgtgcacg gccccaagtc cactatgatt     2040

acaacgggtt tccttactgg ggccaaggga ctcccgtcac tgtctctagc ggtggcggag     2100

ggtctggggg tggcggatcc ggaggtggtg gctctgcaca agacatccag atgacccagt     2160

ctccaagcag cctgtctgca agcgtggggg acagggtcac catgacctgc agtgccagct     2220

caagtgtaag ttacatgaac tggtaccagc agaagccggg caaggccccc aaaagatgga     2280

tttatgactc atccaaactg gcttctggag tccctgctcg cttcagtggc agtgggtctg     2340

ggaccgacta taccctcaca atcagcagcc tgcagcccga agatttcgcc acttattact     2400

gccagcagtg gagtcgtaac ccacccacgt tcggaggggg gaccaagcta caaattacat     2460

cctccagcta a                                                          2471


<210>  63
<211>  795
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAG100 bispecific antibody

<400>  63

Gln Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Val 
    130                 135                 140                 


Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Thr Leu Ser Ile 
145                 150                 155                 160 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser Gly Val Ser Trp 
                165                 170                 175     


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
            180                 185                 190         


Gly Asp Gly Ser Thr Asn Tyr His Pro Ser Leu Lys Ser Arg Leu Ser 
        195                 200                 205             


Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Ser 
    210                 215                 220                 


Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Lys Gly Gly Tyr 
225                 230                 235                 240 


Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Asp 
                245                 250                 255     


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
            260                 265                 270         


Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly Thr 
        275                 280                 285             


Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 
    290                 295                 300                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 
305                 310                 315                 320 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                325                 330                 335     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            340                 345                 350         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        355                 360                 365             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    370                 375                 380                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr 
385                 390                 395                 400 


Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                405                 410                 415     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            420                 425                 430         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        435                 440                 445             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    450                 455                 460                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
465                 470                 475                 480 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            500                 505                 510         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln 
        515                 520                 525             


Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His 
    530                 535                 540                 


Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
545                 550                 555                 560 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
                565                 570                 575     


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
            580                 585                 590         


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
        595                 600                 605             


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
    610                 615                 620                 


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
625                 630                 635                 640 


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
                645                 650                 655     


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile 
        675                 680                 685             


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
    690                 695                 700                 


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
705                 710                 715                 720 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser 
                725                 730                 735     


Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            740                 745                 750         


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
        755                 760                 765             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly 
    770                 775                 780                 


Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
785                 790                 795 


<210>  64
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRA222 variable heavy chain

<400>  64
caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agc                                                                    363


<210>  65
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA222 anti-CD3 variable heavy chain

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  66
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRA222 variable light chain

<400>  66
gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg       60

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagaag      120

ccgggcaagg cccccaaaag atggatttat gactcatcca aactggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc gactataccc tcacaatcag cagcctgcag      240

cccgaagatt tcgccactta ttactgccag cagtggagtc gtaacccacc cacgttcgga      300

ggggggacca agctacaaat taca                                             324


<210>  67
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA222 anti-CD3 variable light chain

<400>  67

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        35                  40                  45              


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
            100                 105             


<210>  68
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H1 heavy chain

<400>  68
caggtccagc tggtgcagtc tggggctgaa gtgaagaagc ctggggcctc agtgaaggtg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaaacaggcc      120

cctggacagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacaa ggccacattg actgcagaca aatcctccag tacagcctac      240

atgcaactga gtagcctgag gtctgaggac accgcagtct attactgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactctggt cactgtctct      360

agc                                                                    363


<210>  69
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H1 heavy chain

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  70
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H2 heavy chain

<400>  70
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacaa ggccacattg actgcagaca aatccaagaa cacagcctac      240

atggagctga gtagcctgag gtctgaggac accgcagtct attactgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactctggt cactgtctct      360

agc                                                                    363


<210>  71
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H2 heavy chain

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  72
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H3 heavy chain

<400>  72
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agc                                                                    363


<210>  73
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H3 heavy chain

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  74
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H4 heavy chain

<400>  74
caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agc                                                                    363


<210>  75
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H4 heavy chain

<400>  75

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  76
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H5 heavy chain

<400>  76
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agatctacga tgcactgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagaccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  77
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H5 heavy chain

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  78
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H6 heavy chain

<400>  78
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agatctacga tgcactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggaccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  79
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant H6 heavy chain

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  80
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant L1 light chain

<400>  80
gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg       60

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagaag      120

ccgggcaagg cccccaaaag atggatttat gactcatcca aactggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc gactataccc tcacaatcag cagcctgcag      240

cccgaagatt tcgccactta ttactgccag cagtggagtc gtaacccacc cacgttcgga      300

ggggggacca agctacaaat taca                                             324


<210>  81
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 variant L1 light chain

<400>  81

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        35                  40                  45              


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
            100                 105             


<210>  82
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant L2 light chain

<400>  82
gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg       60

gtcaccatca cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagacc      120

cccggcaagg cccccaaaag atggatttat gactcatcca aactggcttc tggagtccct      180

agccgcttca gtggcagtgg gtctgggacc gacttcaccc tcacaatcag cagcctgcag      240

cccgaagata tcgccactta ttactgccag cagtggagtc gtaacccacc cacgttcgga      300

caggggacca agctacaaat taca                                             324


<210>  83
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 variant L2 light chain

<400>  83

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp 
        35                  40                  45              


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
            100                 105             


<210>  84
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant L3 light chain

<400>  84
gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg       60

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagaag      120

ccgggcaagg cccccaaact cctcatttat gactcatcca aactggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc gactataccc tcacaatcag cagcctgcag      240

cccgaagatt tcgccactta ttactgccag cagtggagtc gtaacccacc cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  85
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 variant L3 light chain

<400>  85

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  86
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 variant L4 light chain

<400>  86
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgccagctc aagtgtaagt tacatgaact ggtaccaaca gaaacctggc      120

caggctccca ggctcctcat ctatgactca tccaaactgg cttctggcat cccagccagg      180

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tcagcagtgg agtcgtaacc cacccacttt cggcggaggg      300

accaaggtgg agatcaaa                                                    318


<210>  87
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 variant L4 light chain

<400>  87

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  88
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA209 scFv

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr 
                


<210>  89
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA222 scFv

<400>  89

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr 
                


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS 7 heavy chain CDR1

<400>  90

Arg Ser Thr Met His 
1               5   


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS 7 heavy chain CDR2

<400>  91

Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS 7 heavy chain CDR3

<400>  92

Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10          


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS 7 light chain CDR1

<400>  93

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS 7 light chain CDR2

<400>  94

Asp Ser Ser Lys Leu Ala Ser 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS 7 light chain CDR3

<400>  95

Trp Ser Arg Asn Pro Pro Thr 
1               5           


<210>  96
<211>  121
<212>  PRT
<213>  Mus sp.

<400>  96

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  97
<211>  107
<212>  PRT
<213>  Mus sp.

<400>  97

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  98
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuM291 Variable heavy

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Gly Tyr Thr His Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  99
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuM291 Variable light

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  100

Gly Gly Gly Gly Ser 
1               5   


<210>  101
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 null2 hinge and CH2CH3 domain

<400>  101
gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg       60

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggt                                   693


<210>  102
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 null2 hinge and CH2CH3 domain

<400>  102

Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
1               5                   10                  15      


Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly Gln Gly 
            20                  25                  30          


Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
        35                  40                  45              


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                85                  90                  95      


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
    130                 135                 140                 


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            260                 265                 270         


<210>  103
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 N297A hinge and CH2CH3 domain

<400>  103
gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgca       60

ggtgctccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc      180

aactggtacg tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

ttcgccagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac      300

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagag ccacaggtgt acaccctgcc cccatcccag      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca ggctaaccgt ggacaagagc      600

cggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacacaga agagcctctc cctgtctccg ggt                                   693


<210>  104
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 N297A hinge and CH2CH3 domain

<400>  104

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro 
225                 230 


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sss(s)-hIgG1 hinge

<400>  105

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  106
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  csc(s)-hIgG1 hinge

<400>  106

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ssc(s)-hIgG1 hinge

<400>  107

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scc(s)-hIgG1 hinge

<400>  108

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  css(s)-hIgG1 hinge

<400>  109

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  110
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scs(s)-hIgG1 hinge

<400>  110

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  111
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ccc(s)-hIgG1 hinge

<400>  111

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  112
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ccc(p)-hIgG1 hinge

<400>  112

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  113
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sss(p)-hIgG1 hinge

<400>  113

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  114
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  csc(p)-hIgG1 hinge

<400>  114

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  115
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ssc(p)-hIgG1 hinge

<400>  115

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  116
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scc(p)-hIgG1 hinge

<400>  116

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  117
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  css(p)-hIgG1 hinge

<400>  117

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scs(p)-hIgG1 hinge

<400>  118

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  119
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Scppcp

<400>  119

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  120
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STD1

<400>  120

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  121
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STD2

<400>  121

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser 
        35              


<210>  122
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1

<400>  122

Asn Ser 
1       


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2

<400>  123

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3

<400>  124

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  125
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4

<400>  125

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H5

<400>  126

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  127
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H6

<400>  127

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H7

<400>  128

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  129
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3

<400>  129

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  130
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H105

<400>  130

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  131
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)4

<400>  131

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  132
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75 NKG2A quadruple mutant

<400>  132

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  133
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H83 NKG2A derived

<400>  133

Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  134
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H106 NKG2A derived

<400>  134

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser 
        


<210>  135
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H81 NKG2D derived

<400>  135

Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  


<210>  136
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H91 NKG2D derived

<400>  136

Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  137
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H94

<400>  137

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H98 NKG2A derived

<400>  138

Ser Ser Leu Asn Thr Gly Thr Gln 
1               5               


<210>  139
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H16

<400>  139

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  140
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H17

<400>  140

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  141
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H18

<400>  141

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  142
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H19

<400>  142

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  143
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H20

<400>  143

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Asn Ser 
1               5                   10                  15  


<210>  144
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H21

<400>  144

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H22

<400>  145

Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 
1               5                   10                  15  


<210>  146
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H23

<400>  146

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  147
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H24

<400>  147

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asn Ser 
1               5                   10                  15  


<210>  148
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H25

<400>  148

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H26

<400>  149

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  150
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H27

<400>  150

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  151
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H28

<400>  151

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser 
1               5                   10                  15  


<210>  152
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H30

<400>  152

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Asn Ser 
1               5                   10                  15  


<210>  153
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H32

<400>  153

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10                  15  


<210>  154
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H33

<400>  154

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  155
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H36

<400>  155

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H40

<400>  156

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H41

<400>  157

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  158
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H42

<400>  158

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  159
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H44

<400>  159

Gly Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  160
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H45

<400>  160

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  161
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H46

<400>  161

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 
1               5                   10          


<210>  162
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H47

<400>  162

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H48

<400>  163

Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10      


<210>  164
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H50

<400>  164

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  165
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H51

<400>  165

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H52

<400>  166

Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ser 
1               5                   10      


<210>  167
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H53

<400>  167

Ser Gln Pro Glu Ile Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10                  15      


<210>  168
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H54

<400>  168

Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  169
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H55

<400>  169

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  170
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H56

<400>  170

Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10          


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H57

<400>  171

Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10  


<210>  172
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H58

<400>  172

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  173
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H59

<400>  173

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  174
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H60

<400>  174

Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Asn Ser 
1               5                   10                  15  


<210>  175
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H61

<400>  175

Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
1               5                   10                  15      


Asp Cys Pro Asn Ser 
            20      


<210>  176
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H62

<400>  176

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Cys Pro Asn Ser 
            20      


<210>  177
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H63

<400>  177

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  178
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAG100 scfv

<400>  178

Gln Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Val 
    130                 135                 140                 


Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Thr Leu Ser Ile 
145                 150                 155                 160 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser Gly Val Ser Trp 
                165                 170                 175     


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
            180                 185                 190         


Gly Asp Gly Ser Thr Asn Tyr His Pro Ser Leu Lys Ser Arg Leu Ser 
        195                 200                 205             


Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu Lys Leu Asn Ser 
    210                 215                 220                 


Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Lys Gly Gly Tyr 
225                 230                 235                 240 


Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255 


<210>  179
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuM291 scfv

<400>  179

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Gly Tyr Thr His Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
                165                 170                 175     


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
            180                 185                 190         


Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250     


<210>  180
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G28-1 alternative scfv

<400>  180

Ala Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Thr Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Ser Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln Pro Glu Asp Ser 
    210                 215                 220                 


Gly Ser Tyr Phe Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Glu Leu Glu Ile Lys Arg 
                245                 


