                         SEQUENCE LISTING

<110>  Rush University Medical Center
 
<120>  Methods for Treating Cancer

<130>  14904/53

<150>  61/799,888
<151>  2013-03-15

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptic peptide containing potential ubiquitination sites of 
       SUMO-2

<400>  1

Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe Lys Ile Lys 
1               5                   10                  


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptic peptides containing potential ubiquitination sites of 
       SUMO-2

<400>  2

His Thr Pro Leu Ser Lys Leu Met Lys 
1               5                   


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptic peptides containing potential ubiquitination sites of 
       SUMO-2

<400>  3

Glu Gly Val Lys Thr Glu Asn Asn Asp His Ile Asn Leu Lys 
1               5                   10                  


<210>  4
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Asp Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asn Asp 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly 
    50                  55                  60                  


Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Tyr 
                85                  90                  95  


<210>  5
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  5

Ile Thr Val Ile 
1               


<210>  6
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  6

Leu Thr Val Ile 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  7

Leu Gln Leu Val 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  8

Ile Ile Pro Leu 
1               


<210>  9
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  9

Leu Trp Val Ile 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  10

Leu Ile Trp Val 
1               


<210>  11
<211>  4
<212>  PRT
<213>  mouse

<400>  11

Leu Glu Val Leu 
1               


<210>  12
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210>  13
<211>  854
<212>  PRT
<213>  Mus musculus

<400>  13

Met Gly Ser Leu Thr Met Lys Ser Gln Leu Gln Ile Thr Val Ile Ser 
1               5                   10                  15      


Ala Lys Leu Lys Glu Asn Lys Lys Asn Trp Phe Gly Pro Ser Pro Tyr 
            20                  25                  30          


Val Glu Val Thr Val Asp Gly Gln Ser Lys Lys Thr Glu Lys Cys Asn 
        35                  40                  45              


Asn Thr Asn Ser Pro Lys Trp Lys Gln Pro Leu Thr Val Ile Val Thr 
    50                  55                  60                  


Pro Thr Ser Lys Leu Cys Phe Arg Val Trp Ser His Gln Thr Leu Lys 
65                  70                  75                  80  


Ser Asp Val Leu Leu Gly Thr Ala Gly Leu Asp Ile Tyr Glu Thr Leu 
                85                  90                  95      


Lys Ser Asn Asn Met Lys Leu Glu Glu Val Val Met Thr Leu Gln Leu 
            100                 105                 110         


Val Gly Asp Lys Glu Pro Thr Glu Thr Met Gly Asp Leu Ser Val Cys 
        115                 120                 125             


Leu Asp Gly Leu Gln Val Glu Ala Glu Val Val Thr Asn Gly Glu Thr 
    130                 135                 140                 


Ser Cys Ser Glu Ser Thr Thr Gln Asn Asp Asp Gly Cys Arg Thr Arg 
145                 150                 155                 160 


Asp Asp Thr Arg Val Ser Thr Asn Gly Ser Glu Asp Pro Glu Val Ala 
                165                 170                 175     


Ala Ser Gly Glu Asn Lys Arg Ala Asn Gly Asn Asn Ser Pro Ser Leu 
            180                 185                 190         


Ser Asn Gly Gly Phe Lys Pro Ser Arg Pro Pro Arg Pro Ser Arg Pro 
        195                 200                 205             


Pro Pro Pro Thr Pro Arg Arg Pro Ala Ser Val Asn Gly Ser Pro Ser 
    210                 215                 220                 


Thr Asn Ser Asp Ser Asp Gly Ser Ser Thr Gly Ser Leu Pro Pro Thr 
225                 230                 235                 240 


Asn Thr Asn Val Asn Thr Ser Thr Ser Glu Gly Ala Thr Ser Gly Leu 
                245                 250                 255     


Ile Ile Pro Leu Thr Ile Ser Gly Gly Ser Gly Pro Arg Pro Leu Asn 
            260                 265                 270         


Thr Val Ser Gln Ala Pro Leu Pro Pro Gly Trp Glu Gln Arg Val Asp 
        275                 280                 285             


Gln His Gly Arg Val Tyr Tyr Val Asp His Val Glu Lys Arg Thr Thr 
    290                 295                 300                 


Trp Asp Arg Pro Glu Pro Leu Pro Pro Gly Trp Glu Arg Arg Val Asp 
305                 310                 315                 320 


Asn Met Gly Arg Ile Tyr Tyr Val Asp His Phe Thr Arg Thr Thr Thr 
                325                 330                 335     


Trp Gln Arg Pro Thr Leu Glu Ser Val Arg Asn Tyr Glu Gln Trp Gln 
            340                 345                 350         


Leu Gln Arg Ser Gln Leu Gln Gly Ala Met Gln Gln Phe Asn Gln Arg 
        355                 360                 365             


Phe Ile Tyr Gly Asn Gln Asp Leu Phe Ala Thr Ser Gln Asn Lys Glu 
    370                 375                 380                 


Phe Asp Pro Leu Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Thr Asp 
385                 390                 395                 400 


Ser Asn Gly Arg Val Tyr Phe Val Asn His Asn Thr Arg Ile Thr Gln 
                405                 410                 415     


Trp Glu Asp Pro Arg Ser Gln Gly Gln Leu Asn Glu Lys Pro Leu Pro 
            420                 425                 430         


Glu Gly Trp Glu Met Arg Phe Thr Val Asp Gly Ile Pro Tyr Phe Val 
        435                 440                 445             


Asp His Asn Arg Arg Ala Thr Thr Tyr Ile Asp Pro Arg Thr Gly Lys 
    450                 455                 460                 


Ser Ala Leu Asp Asn Gly Pro Gln Ile Ala Tyr Val Arg Asp Phe Lys 
465                 470                 475                 480 


Ala Lys Val Gln Tyr Phe Arg Phe Trp Cys Gln Gln Leu Ala Met Pro 
                485                 490                 495     


Gln His Ile Lys Ile Thr Val Thr Arg Lys Thr Leu Phe Glu Asp Ser 
            500                 505                 510         


Phe Gln Gln Ile Met Ser Phe Ser Pro Gln Asp Leu Arg Arg Arg Leu 
        515                 520                 525             


Trp Val Ile Phe Pro Gly Glu Glu Gly Leu Asp Tyr Gly Gly Val Ala 
    530                 535                 540                 


Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu Asn Pro Met Tyr 
545                 550                 555                 560 


Cys Leu Phe Glu Tyr Ala Gly Lys Asp Asn Tyr Cys Leu Gln Ile Asn 
                565                 570                 575     


Pro Ala Ser Tyr Ile Asn Pro Asp His Leu Lys Tyr Phe Arg Phe Ile 
            580                 585                 590         


Gly Arg Phe Ile Ala Met Ala Leu Phe His Gly Lys Phe Ile Asp Thr 
        595                 600                 605             


Gly Phe Ser Leu Pro Phe Tyr Lys Arg Ile Leu Asn Lys Pro Val Gly 
    610                 615                 620                 


Leu Lys Asp Leu Glu Ser Ile Asp Pro Glu Phe Tyr Asn Ser Leu Ile 
625                 630                 635                 640 


Trp Val Lys Glu Asn Asn Ile Glu Glu Cys Gly Leu Glu Met Tyr Phe 
                645                 650                 655     


Ser Val Asp Lys Glu Ile Leu Gly Glu Ile Lys Ser His Asp Leu Lys 
            660                 665                 670         


Pro Asn Gly Gly Asn Ile Leu Val Thr Glu Glu Asn Lys Glu Glu Tyr 
        675                 680                 685             


Ile Arg Met Val Ala Glu Trp Arg Leu Ser Arg Gly Val Glu Glu Gln 
    690                 695                 700                 


Thr Gln Ala Phe Phe Glu Gly Phe Asn Glu Ile Leu Pro Gln Gln Tyr 
705                 710                 715                 720 


Leu Gln Tyr Phe Asp Ala Lys Glu Leu Glu Val Leu Leu Cys Gly Met 
                725                 730                 735     


Gln Glu Ile Asp Leu Asn Asp Trp Gln Arg His Ala Ile Tyr Arg His 
            740                 745                 750         


Tyr Thr Arg Thr Ser Lys Gln Ile Met Trp Phe Trp Gln Phe Val Lys 
        755                 760                 765             


Glu Ile Asp Asn Glu Lys Arg Met Arg Leu Leu Gln Phe Val Thr Gly 
    770                 775                 780                 


Thr Cys Arg Leu Pro Val Gly Gly Phe Ala Asp Leu Met Gly Ser Asn 
785                 790                 795                 800 


Gly Pro Gln Lys Phe Cys Ile Glu Lys Val Gly Lys Glu Asn Trp Leu 
                805                 810                 815     


Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr Lys 
            820                 825                 830         


Ser Tyr Glu Gln Leu Lys Glu Lys Leu Leu Phe Ala Ile Glu Glu Thr 
        835                 840                 845             


Glu Gly Phe Gly Gln Glu 
    850                 


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SUMO interaction motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Isoleucine, Leucin or Valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Isoleucin, Leucine or Valine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Isoleucin, Leucine or Valine

<400>  14

Xaa Xaa Xaa Xaa 
1               


