                         SEQUENCE LISTING

<110>  Battelle Energy Alliance, LLC
       Thompson, Vicki S
       Lacey, Jeffrey  A
       Park, Shawna
       Apel, William A
 
<120>  ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING  
       AN INDIVIDUAL OR SOURCE OF A BIOLOGICAL MATERIAL 

<130>  63077-1040

<160>  197   

<170>  PatentIn version 3.5

<210>  1
<211>  2768
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Val Leu Glu Ile Phe Thr Leu Leu Ala Ser Ile Cys Trp 
1               5                   10                  15      


Val Ser Ala Asn Ile Phe Glu Tyr Gln Val Asp Ala Gln Pro Leu Arg 
            20                  25                  30          


Pro Cys Glu Leu Gln Arg Glu Thr Ala Phe Leu Lys Gln Ala Asp Tyr 
        35                  40                  45              


Val Pro Gln Cys Ala Glu Asp Gly Ser Phe Gln Thr Val Gln Cys Gln 
    50                  55                  60                  


Asn Asp Gly Arg Ser Cys Trp Cys Val Gly Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Leu Gly Ser Arg Gln Pro Gly Arg Pro Val Ala Cys Leu Ser Phe Cys 
                85                  90                  95      


Gln Leu Gln Lys Gln Gln Ile Leu Leu Ser Gly Tyr Ile Asn Ser Thr 
            100                 105                 110         


Asp Thr Ser Tyr Leu Pro Gln Cys Gln Asp Ser Gly Asp Tyr Ala Pro 
        115                 120                 125             


Val Gln Cys Asp Val Gln Gln Val Gln Cys Trp Cys Val Asp Ala Glu 
    130                 135                 140                 


Gly Met Glu Val Tyr Gly Thr Arg Gln Leu Gly Arg Pro Lys Arg Cys 
145                 150                 155                 160 


Pro Arg Ser Cys Glu Ile Arg Asn Arg Arg Leu Leu His Gly Val Gly 
                165                 170                 175     


Asp Lys Ser Pro Pro Gln Cys Ser Ala Glu Gly Glu Phe Met Pro Val 
            180                 185                 190         


Gln Cys Lys Phe Val Asn Thr Thr Asp Met Met Ile Phe Asp Leu Val 
        195                 200                 205             


His Ser Tyr Asn Arg Phe Pro Asp Ala Phe Val Thr Phe Ser Ser Phe 
    210                 215                 220                 


Gln Arg Arg Phe Pro Glu Val Ser Gly Tyr Cys His Cys Ala Asp Ser 
225                 230                 235                 240 


Gln Gly Arg Glu Leu Ala Glu Thr Gly Leu Glu Leu Leu Leu Asp Glu 
                245                 250                 255     


Ile Tyr Asp Thr Ile Phe Ala Gly Leu Asp Leu Pro Ser Thr Phe Thr 
            260                 265                 270         


Glu Thr Thr Leu Tyr Arg Ile Leu Gln Arg Arg Phe Leu Ala Val Gln 
        275                 280                 285             


Ser Val Ile Ser Gly Arg Phe Arg Cys Pro Thr Lys Cys Glu Val Glu 
    290                 295                 300                 


Arg Phe Thr Ala Thr Ser Phe Gly His Pro Tyr Val Pro Ser Cys Arg 
305                 310                 315                 320 


Arg Asn Gly Asp Tyr Gln Ala Val Gln Cys Gln Thr Glu Gly Pro Cys 
                325                 330                 335     


Trp Cys Val Asp Ala Gln Gly Lys Glu Met His Gly Thr Arg Gln Gln 
            340                 345                 350         


Gly Glu Pro Pro Ser Cys Ala Glu Gly Gln Ser Cys Ala Ser Glu Arg 
        355                 360                 365             


Gln Gln Ala Leu Ser Arg Leu Tyr Phe Gly Thr Ser Gly Tyr Phe Ser 
    370                 375                 380                 


Gln His Asp Leu Phe Ser Ser Pro Glu Lys Arg Trp Ala Ser Pro Arg 
385                 390                 395                 400 


Val Ala Arg Phe Ala Thr Ser Cys Pro Pro Thr Ile Lys Glu Leu Phe 
                405                 410                 415     


Val Asp Ser Gly Leu Leu Arg Pro Met Val Glu Gly Gln Ser Gln Gln 
            420                 425                 430         


Phe Ser Val Ser Glu Asn Leu Leu Lys Glu Ala Ile Arg Ala Ile Phe 
        435                 440                 445             


Pro Ser Arg Gly Leu Ala Arg Leu Ala Leu Gln Phe Thr Thr Asn Pro 
    450                 455                 460                 


Lys Arg Leu Gln Gln Asn Leu Phe Gly Gly Lys Phe Leu Val Asn Val 
465                 470                 475                 480 


Gly Gln Phe Asn Leu Ser Gly Ala Leu Gly Thr Arg Gly Thr Phe Asn 
                485                 490                 495     


Phe Ser Gln Phe Phe Gln Gln Leu Gly Leu Ala Ser Phe Leu Asn Gly 
            500                 505                 510         


Gly Arg Gln Glu Asp Leu Ala Lys Pro Leu Ser Val Gly Leu Asp Ser 
        515                 520                 525             


Asn Ser Ser Thr Gly Thr Pro Glu Ala Ala Lys Lys Asp Gly Thr Met 
    530                 535                 540                 


Asn Lys Pro Thr Val Gly Ser Phe Gly Phe Glu Ile Asn Leu Gln Glu 
545                 550                 555                 560 


Asn Gln Asn Ala Leu Lys Phe Leu Ala Ser Leu Leu Glu Leu Pro Glu 
                565                 570                 575     


Phe Leu Leu Phe Leu Gln His Ala Ile Ser Val Pro Glu Asp Val Ala 
            580                 585                 590         


Arg Asp Leu Gly Asp Val Met Glu Thr Val Leu Ser Ser Gln Thr Cys 
        595                 600                 605             


Glu Gln Thr Pro Glu Arg Leu Phe Val Pro Ser Cys Thr Thr Glu Gly 
    610                 615                 620                 


Ser Tyr Glu Asp Val Gln Cys Phe Ser Gly Glu Cys Trp Cys Val Asn 
625                 630                 635                 640 


Ser Trp Gly Lys Glu Leu Pro Gly Ser Arg Val Arg Gly Gly Gln Pro 
                645                 650                 655     


Arg Cys Pro Thr Asp Cys Glu Lys Gln Arg Ala Arg Met Gln Ser Leu 
            660                 665                 670         


Met Gly Ser Gln Pro Ala Gly Ser Thr Leu Phe Val Pro Ala Cys Thr 
        675                 680                 685             


Ser Glu Gly His Phe Leu Pro Val Gln Cys Phe Asn Ser Glu Cys Tyr 
    690                 695                 700                 


Cys Val Asp Ala Glu Gly Gln Ala Ile Pro Gly Thr Arg Ser Ala Ile 
705                 710                 715                 720 


Gly Lys Pro Lys Lys Cys Pro Thr Pro Cys Gln Leu Gln Ser Glu Gln 
                725                 730                 735     


Ala Phe Leu Arg Thr Val Gln Ala Leu Leu Ser Asn Ser Ser Met Leu 
            740                 745                 750         


Pro Thr Leu Ser Asp Thr Tyr Ile Pro Gln Cys Ser Thr Asp Gly Gln 
        755                 760                 765             


Trp Arg Gln Val Gln Cys Asn Gly Pro Pro Glu Gln Val Phe Glu Leu 
    770                 775                 780                 


Tyr Gln Arg Trp Glu Ala Gln Asn Lys Gly Gln Asp Leu Thr Pro Ala 
785                 790                 795                 800 


Lys Leu Leu Val Lys Ile Met Ser Tyr Arg Glu Ala Ala Ser Gly Asn 
                805                 810                 815     


Phe Ser Leu Phe Ile Gln Ser Leu Tyr Glu Ala Gly Gln Gln Asp Val 
            820                 825                 830         


Phe Pro Val Leu Ser Gln Tyr Pro Ser Leu Gln Asp Val Pro Leu Ala 
        835                 840                 845             


Ala Leu Glu Gly Lys Arg Pro Gln Pro Arg Glu Asn Ile Leu Leu Glu 
    850                 855                 860                 


Pro Tyr Leu Phe Trp Gln Ile Leu Asn Gly Gln Leu Ser Gln Tyr Pro 
865                 870                 875                 880 


Gly Ser Tyr Ser Asp Phe Ser Thr Pro Leu Ala His Phe Asp Leu Arg 
                885                 890                 895     


Asn Cys Trp Cys Val Asp Glu Ala Gly Gln Glu Leu Glu Gly Met Arg 
            900                 905                 910         


Ser Glu Pro Ser Lys Leu Pro Thr Cys Pro Gly Ser Cys Glu Glu Ala 
        915                 920                 925             


Lys Leu Arg Val Leu Gln Phe Ile Arg Glu Thr Glu Glu Ile Val Ser 
    930                 935                 940                 


Ala Ser Asn Ser Ser Arg Phe Pro Leu Gly Glu Ser Phe Leu Val Ala 
945                 950                 955                 960 


Lys Gly Ile Arg Leu Arg Asn Glu Asp Leu Gly Leu Pro Pro Leu Phe 
                965                 970                 975     


Pro Pro Arg Glu Ala Phe Ala Glu Gln Phe Leu Arg Gly Ser Asp Tyr 
            980                 985                 990         


Ala Ile Arg Leu Ala Ala Gln Ser  Thr Leu Ser Phe Tyr  Gln Arg Arg 
        995                 1000                 1005             


Arg Phe  Ser Pro Asp Asp Ser  Ala Gly Ala Ser Ala  Leu Leu Arg 
    1010                 1015                 1020             


Ser Gly  Pro Tyr Met Pro Gln  Cys Asp Ala Phe Gly  Ser Trp Glu 
    1025                 1030                 1035             


Pro Val  Gln Cys His Ala Gly  Thr Gly His Cys Trp  Cys Val Asp 
    1040                 1045                 1050             


Glu Lys  Gly Gly Phe Ile Pro  Gly Ser Leu Thr Ala  Arg Ser Leu 
    1055                 1060                 1065             


Gln Ile  Pro Gln Cys Pro Thr  Thr Cys Glu Lys Ser  Arg Thr Ser 
    1070                 1075                 1080             


Gly Leu  Leu Ser Ser Trp Lys  Gln Ala Arg Ser Gln  Glu Asn Pro 
    1085                 1090                 1095             


Ser Pro  Lys Asp Leu Phe Val  Pro Ala Cys Leu Glu  Thr Gly Glu 
    1100                 1105                 1110             


Tyr Ala  Arg Leu Gln Ala Ser  Gly Ala Gly Thr Trp  Cys Val Asp 
    1115                 1120                 1125             


Pro Ala  Ser Gly Glu Glu Leu  Arg Pro Gly Ser Ser  Ser Ser Ala 
    1130                 1135                 1140             


Gln Cys  Pro Ser Leu Cys Asn  Val Leu Lys Ser Gly  Val Leu Ser 
    1145                 1150                 1155             


Arg Arg  Val Ser Pro Gly Tyr  Val Pro Ala Cys Arg  Ala Glu Asp 
    1160                 1165                 1170             


Gly Gly  Phe Ser Pro Val Gln  Cys Asp Gln Ala Gln  Gly Ser Cys 
    1175                 1180                 1185             


Trp Cys  Val Met Asp Ser Gly  Glu Glu Val Pro Gly  Thr Arg Val 
    1190                 1195                 1200             


Thr Gly  Gly Gln Pro Ala Cys  Glu Ser Pro Arg Cys  Pro Leu Pro 
    1205                 1210                 1215             


Phe Asn  Ala Ser Glu Val Val  Gly Gly Thr Ile Leu  Cys Glu Thr 
    1220                 1225                 1230             


Ile Ser  Gly Pro Thr Gly Ser  Ala Met Gln Gln Cys  Gln Leu Leu 
    1235                 1240                 1245             


Cys Arg  Gln Gly Ser Trp Ser  Val Phe Pro Pro Gly  Pro Leu Ile 
    1250                 1255                 1260             


Cys Ser  Leu Glu Ser Gly Arg  Trp Glu Ser Gln Leu  Pro Gln Pro 
    1265                 1270                 1275             


Arg Ala  Cys Gln Arg Pro Gln  Leu Trp Gln Thr Ile  Gln Thr Gln 
    1280                 1285                 1290             


Gly His  Phe Gln Leu Gln Leu  Pro Pro Gly Lys Met  Cys Ser Ala 
    1295                 1300                 1305             


Asp Tyr  Ala Asp Leu Leu Gln  Thr Phe Gln Val Phe  Ile Leu Asp 
    1310                 1315                 1320             


Glu Leu  Thr Ala Arg Gly Phe  Cys Gln Ile Gln Val  Lys Thr Phe 
    1325                 1330                 1335             


Gly Thr  Leu Val Ser Ile Pro  Val Cys Asn Asn Ser  Ser Val Gln 
    1340                 1345                 1350             


Val Gly  Cys Leu Thr Arg Glu  Arg Leu Gly Val Asn  Val Thr Trp 
    1355                 1360                 1365             


Lys Ser  Arg Leu Glu Asp Ile  Pro Val Ala Ser Leu  Pro Asp Leu 
    1370                 1375                 1380             


His Asp  Ile Glu Arg Ala Leu  Val Gly Lys Asp Leu  Leu Gly Arg 
    1385                 1390                 1395             


Phe Thr  Asp Leu Ile Gln Ser  Gly Ser Phe Gln Leu  His Leu Asp 
    1400                 1405                 1410             


Ser Lys  Thr Phe Pro Ala Glu  Thr Ile Arg Phe Leu  Gln Gly Asp 
    1415                 1420                 1425             


His Phe  Gly Thr Ser Pro Arg  Thr Trp Phe Gly Cys  Ser Glu Gly 
    1430                 1435                 1440             


Phe Tyr  Gln Val Leu Thr Ser  Glu Ala Ser Gln Asp  Gly Leu Gly 
    1445                 1450                 1455             


Cys Val  Lys Cys Pro Glu Gly  Ser Tyr Ser Gln Asp  Glu Glu Cys 
    1460                 1465                 1470             


Ile Pro  Cys Pro Val Gly Phe  Tyr Gln Glu Gln Ala  Gly Ser Leu 
    1475                 1480                 1485             


Ala Cys  Val Pro Cys Pro Val  Gly Arg Thr Thr Ile  Ser Ala Gly 
    1490                 1495                 1500             


Ala Phe  Ser Gln Thr His Cys  Val Thr Asp Cys Gln  Arg Asn Glu 
    1505                 1510                 1515             


Ala Gly  Leu Gln Cys Asp Gln  Asn Gly Gln Tyr Arg  Ala Ser Gln 
    1520                 1525                 1530             


Lys Asp  Arg Gly Ser Gly Lys  Ala Phe Cys Val Asp  Gly Glu Gly 
    1535                 1540                 1545             


Arg Arg  Leu Pro Trp Trp Glu  Thr Glu Ala Pro Leu  Glu Asp Ser 
    1550                 1555                 1560             


Gln Cys  Leu Met Met Gln Lys  Phe Glu Lys Val Pro  Glu Ser Lys 
    1565                 1570                 1575             


Val Ile  Phe Asp Ala Asn Ala  Pro Val Ala Val Arg  Ser Lys Val 
    1580                 1585                 1590             


Pro Asp  Ser Glu Phe Pro Val  Met Gln Cys Leu Thr  Asp Cys Thr 
    1595                 1600                 1605             


Glu Asp  Glu Ala Cys Ser Phe  Phe Thr Val Ser Thr  Thr Glu Pro 
    1610                 1615                 1620             


Glu Ile  Ser Cys Asp Phe Tyr  Ala Trp Thr Ser Asp  Asn Val Ala 
    1625                 1630                 1635             


Cys Met  Thr Ser Asp Gln Lys  Arg Asp Ala Leu Gly  Asn Ser Lys 
    1640                 1645                 1650             


Ala Thr  Ser Phe Gly Ser Leu  Arg Cys Gln Val Lys  Val Arg Ser 
    1655                 1660                 1665             


His Gly  Gln Asp Ser Pro Ala  Val Tyr Leu Lys Lys  Gly Gln Gly 
    1670                 1675                 1680             


Ser Thr  Thr Thr Leu Gln Lys  Arg Phe Glu Pro Thr  Gly Phe Gln 
    1685                 1690                 1695             


Asn Met  Leu Ser Gly Leu Tyr  Asn Pro Ile Val Phe  Ser Ala Ser 
    1700                 1705                 1710             


Gly Ala  Asn Leu Thr Asp Ala  His Leu Phe Cys Leu  Leu Ala Cys 
    1715                 1720                 1725             


Asp Arg  Asp Leu Cys Cys Asp  Gly Phe Val Leu Thr  Gln Val Gln 
    1730                 1735                 1740             


Gly Gly  Ala Ile Ile Cys Gly  Leu Leu Ser Ser Pro  Ser Val Leu 
    1745                 1750                 1755             


Leu Cys  Asn Val Lys Asp Trp  Met Asp Pro Ser Glu  Ala Trp Ala 
    1760                 1765                 1770             


Asn Ala  Thr Cys Pro Gly Val  Thr Tyr Asp Gln Glu  Ser His Gln 
    1775                 1780                 1785             


Val Ile  Leu Arg Leu Gly Asp  Gln Glu Phe Ile Lys  Ser Leu Thr 
    1790                 1795                 1800             


Pro Leu  Glu Gly Thr Gln Asp  Thr Phe Thr Asn Phe  Gln Gln Val 
    1805                 1810                 1815             


Tyr Leu  Trp Lys Asp Ser Asp  Met Gly Ser Arg Pro  Glu Ser Met 
    1820                 1825                 1830             


Gly Cys  Arg Lys Asp Thr Val  Pro Arg Pro Ala Ser  Pro Thr Glu 
    1835                 1840                 1845             


Ala Gly  Leu Thr Thr Glu Leu  Phe Ser Pro Val Asp  Leu Asn Gln 
    1850                 1855                 1860             


Val Ile  Val Asn Gly Asn Gln  Ser Leu Ser Ser Gln  Lys His Trp 
    1865                 1870                 1875             


Leu Phe  Lys His Leu Phe Ser  Ala Gln Gln Ala Asn  Leu Trp Cys 
    1880                 1885                 1890             


Leu Ser  Arg Cys Val Gln Glu  His Ser Phe Cys Gln  Leu Ala Glu 
    1895                 1900                 1905             


Ile Thr  Glu Ser Ala Ser Leu  Tyr Phe Thr Cys Thr  Leu Tyr Pro 
    1910                 1915                 1920             


Glu Ala  Gln Val Cys Asp Asp  Ile Met Glu Ser Asn  Ala Gln Gly 
    1925                 1930                 1935             


Cys Arg  Leu Ile Leu Pro Gln  Met Pro Lys Ala Leu  Phe Arg Lys 
    1940                 1945                 1950             


Lys Val  Ile Leu Glu Asp Lys  Val Lys Asn Phe Tyr  Thr Arg Leu 
    1955                 1960                 1965             


Pro Phe  Gln Lys Leu Met Gly  Ile Ser Ile Arg Asn  Lys Val Pro 
    1970                 1975                 1980             


Met Ser  Glu Lys Ser Ile Ser  Asn Gly Phe Phe Glu  Cys Glu Arg 
    1985                 1990                 1995             


Arg Cys  Asp Ala Asp Pro Cys  Cys Thr Gly Phe Gly  Phe Leu Asn 
    2000                 2005                 2010             


Val Ser  Gln Leu Lys Gly Gly  Glu Val Thr Cys Leu  Thr Leu Asn 
    2015                 2020                 2025             


Ser Leu  Gly Ile Gln Met Cys  Ser Glu Glu Asn Gly  Gly Ala Trp 
    2030                 2035                 2040             


Arg Ile  Leu Asp Cys Gly Ser  Pro Asp Ile Glu Val  His Thr Tyr 
    2045                 2050                 2055             


Pro Phe  Gly Trp Tyr Gln Lys  Pro Ile Ala Gln Asn  Asn Ala Pro 
    2060                 2065                 2070             


Ser Phe  Cys Pro Leu Val Val  Leu Pro Ser Leu Thr  Glu Lys Val 
    2075                 2080                 2085             


Ser Leu  Asp Ser Trp Gln Ser  Leu Ala Leu Ser Ser  Val Val Val 
    2090                 2095                 2100             


Asp Pro  Ser Ile Arg His Phe  Asp Val Ala His Val  Ser Thr Ala 
    2105                 2110                 2115             


Ala Thr  Ser Asn Phe Ser Ala  Val Arg Asp Leu Cys  Leu Ser Glu 
    2120                 2125                 2130             


Cys Ser  Gln His Glu Ala Cys  Leu Ile Thr Thr Leu  Gln Thr Gln 
    2135                 2140                 2145             


Pro Gly  Ala Val Arg Cys Met  Phe Tyr Ala Asp Thr  Gln Ser Cys 
    2150                 2155                 2160             


Thr His  Ser Leu Gln Gly Gln  Asn Cys Arg Leu Leu  Leu Arg Glu 
    2165                 2170                 2175             


Glu Ala  Thr His Ile Tyr Arg  Lys Pro Gly Ile Ser  Leu Leu Ser 
    2180                 2185                 2190             


Tyr Glu  Ala Ser Val Pro Ser  Val Pro Ile Ser Thr  His Gly Arg 
    2195                 2200                 2205             


Leu Leu  Gly Arg Ser Gln Ala  Ile Gln Val Gly Thr  Ser Trp Lys 
    2210                 2215                 2220             


Gln Val  Asp Gln Phe Leu Gly  Val Pro Tyr Ala Ala  Pro Pro Leu 
    2225                 2230                 2235             


Ala Glu  Arg Arg Phe Gln Ala  Pro Glu Pro Leu Asn  Trp Thr Gly 
    2240                 2245                 2250             


Ser Trp  Asp Ala Ser Lys Pro  Arg Ala Ser Cys Trp  Gln Pro Gly 
    2255                 2260                 2265             


Thr Arg  Thr Ser Thr Ser Pro  Gly Val Ser Glu Asp  Cys Leu Tyr 
    2270                 2275                 2280             


Leu Asn  Val Phe Ile Pro Gln  Asn Val Ala Pro Asn  Ala Ser Val 
    2285                 2290                 2295             


Leu Val  Phe Phe His Asn Thr  Met Asp Arg Glu Glu  Ser Glu Gly 
    2300                 2305                 2310             


Trp Pro  Ala Ile Asp Gly Ser  Phe Leu Ala Ala Val  Gly Asn Leu 
    2315                 2320                 2325             


Ile Val  Val Thr Ala Ser Tyr  Arg Val Gly Val Phe  Gly Phe Leu 
    2330                 2335                 2340             


Ser Ser  Gly Ser Gly Glu Val  Ser Gly Asn Trp Gly  Leu Leu Asp 
    2345                 2350                 2355             


Gln Val  Ala Ala Leu Thr Trp  Val Gln Thr His Ile  Arg Gly Phe 
    2360                 2365                 2370             


Gly Gly  Asp Pro Arg Arg Val  Ser Leu Ala Ala Asp  Arg Gly Gly 
    2375                 2380                 2385             


Ala Asp  Val Ala Ser Ile His  Leu Leu Thr Ala Arg  Ala Thr Asn 
    2390                 2395                 2400             


Ser Gln  Leu Phe Arg Arg Ala  Val Leu Met Gly Gly  Ser Ala Leu 
    2405                 2410                 2415             


Ser Pro  Ala Ala Val Ile Ser  His Glu Arg Ala Gln  Gln Gln Ala 
    2420                 2425                 2430             


Ile Ala  Leu Ala Lys Glu Val  Ser Cys Pro Met Ser  Ser Ser Gln 
    2435                 2440                 2445             


Glu Val  Val Ser Cys Leu Arg  Gln Lys Pro Ala Asn  Val Leu Asn 
    2450                 2455                 2460             


Asp Ala  Gln Thr Lys Leu Leu  Ala Val Ser Gly Pro  Phe His Tyr 
    2465                 2470                 2475             


Trp Gly  Pro Val Ile Asp Gly  His Phe Leu Arg Glu  Pro Pro Ala 
    2480                 2485                 2490             


Arg Ala  Leu Lys Arg Ser Leu  Trp Val Glu Val Asp  Leu Leu Ile 
    2495                 2500                 2505             


Gly Ser  Ser Gln Asp Asp Gly  Leu Ile Asn Arg Ala  Lys Ala Val 
    2510                 2515                 2520             


Lys Gln  Phe Glu Glu Ser Arg  Gly Arg Thr Ser Ser  Lys Thr Ala 
    2525                 2530                 2535             


Phe Tyr  Gln Ala Leu Gln Asn  Ser Leu Gly Gly Glu  Asp Ser Asp 
    2540                 2545                 2550             


Ala Arg  Val Glu Ala Ala Ala  Thr Trp Tyr Tyr Ser  Leu Glu His 
    2555                 2560                 2565             


Ser Thr  Asp Asp Tyr Ala Ser  Phe Ser Arg Ala Leu  Glu Asn Ala 
    2570                 2575                 2580             


Thr Arg  Asp Tyr Phe Ile Ile  Cys Pro Ile Ile Asp  Met Ala Ser 
    2585                 2590                 2595             


Ala Trp  Ala Lys Arg Ala Arg  Gly Asn Val Phe Met  Tyr His Ala 
    2600                 2605                 2610             


Pro Glu  Asn Tyr Gly His Gly  Ser Leu Glu Leu Leu  Ala Asp Val 
    2615                 2620                 2625             


Gln Phe  Ala Leu Gly Leu Pro  Phe Tyr Pro Ala Tyr  Glu Gly Gln 
    2630                 2635                 2640             


Phe Ser  Leu Glu Glu Lys Ser  Leu Ser Leu Lys Ile  Met Gln Tyr 
    2645                 2650                 2655             


Phe Ser  His Phe Ile Arg Ser  Gly Asn Pro Asn Tyr  Pro Tyr Glu 
    2660                 2665                 2670             


Phe Ser  Arg Lys Val Pro Thr  Phe Ala Thr Pro Trp  Pro Asp Phe 
    2675                 2680                 2685             


Val Pro  Arg Ala Gly Gly Glu  Asn Tyr Lys Glu Phe  Ser Glu Leu 
    2690                 2695                 2700             


Leu Pro  Asn Arg Gln Gly Leu  Lys Lys Ala Asp Cys  Ser Phe Trp 
    2705                 2710                 2715             


Ser Lys  Tyr Ile Ser Ser Leu  Lys Thr Ser Ala Asp  Gly Ala Lys 
    2720                 2725                 2730             


Gly Gly  Gln Ser Ala Glu Ser  Glu Glu Glu Glu Leu  Thr Ala Gly 
    2735                 2740                 2745             


Ser Gly  Leu Arg Glu Asp Leu  Leu Ser Leu Gln Glu  Pro Gly Ser 
    2750                 2755                 2760             


Lys Thr  Tyr Ser Lys 
    2765             


<210>  2
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Asn Asn Gly Leu Asp Ile Gln Asp Lys Pro Pro Ala Pro Pro 
1               5                   10                  15      


Met Arg Asn Thr Ser Thr Met Ile Gly Ala Gly Ser Lys Asp Ala Gly 
            20                  25                  30          


Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys 
        35                  40                  45              


Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Pro Gly Asp Lys Thr 
    50                  55                  60                  


Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp 
65                  70                  75                  80  


Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe 
                85                  90                  95      


Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile 
            100                 105                 110         


Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu 
        115                 120                 125             


Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser 
    130                 135                 140                 


Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Ala Leu Asn 
145                 150                 155                 160 


Val Lys Ala Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp 
                165                 170                 175     


Glu Asp Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro 
            180                 185                 190         


Arg Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro 
        195                 200                 205             


Leu Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro 
    210                 215                 220                 


Thr Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu 
225                 230                 235                 240 


Lys Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys 
                245                 250                 255     


Leu Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg 
            260                 265                 270         


Phe Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met 
        275                 280                 285             


Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln 
    290                 295                 300                 


Gln Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg 
305                 310                 315                 320 


Glu Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val 
                325                 330                 335     


Gly Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu 
            340                 345                 350         


Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala 
        355                 360                 365             


Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln 
    370                 375                 380                 


Val Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp 
385                 390                 395                 400 


Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro 
                405                 410                 415     


Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala 
            420                 425                 430         


Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile 
        435                 440                 445         


<210>  3
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Cys Gly Arg Thr Ser Cys His Leu Pro Arg Asp Val Leu Thr Arg 
1               5                   10                  15      


Ala Cys Ala Tyr Gln Asp Arg Arg Gly Gln Gln Arg Leu Pro Glu Trp 
            20                  25                  30          


Arg Asp Pro Asp Lys Tyr Cys Pro Ser Tyr Asn Lys Ser Pro Gln Ser 
        35                  40                  45              


Asn Ser Pro Val Leu Leu Ser Arg Leu His Phe Glu Lys Asp Ala Asp 
    50                  55                  60                  


Ser Ser Glu Arg Ile Ile Ala Pro Met Arg Trp Gly Leu Val Pro Ser 
65                  70                  75                  80  


Trp Phe Lys Glu Ser Asp Pro Ser Lys Leu Gln Phe Asn Thr Thr Asn 
                85                  90                  95      


Cys Arg Ser Asp Thr Val Met Glu Lys Arg Ser Phe Lys Val Pro Leu 
            100                 105                 110         


Gly Lys Gly Arg Arg Cys Val Val Leu Ala Asp Gly Phe Tyr Glu Trp 
        115                 120                 125             


Gln Arg Cys Gln Gly Thr Asn Gln Arg Gln Pro Tyr Phe Ile Tyr Phe 
    130                 135                 140                 


Pro Gln Ile Lys Thr Glu Lys Ser Gly Ser Ile Gly Ala Ala Asp Ser 
145                 150                 155                 160 


Pro Glu Asn Trp Glu Lys Val Trp Asp Asn Trp Arg Leu Leu Thr Met 
                165                 170                 175     


Ala Gly Ile Phe Asp Cys Trp Glu Pro Pro Glu Gly Gly Asp Val Leu 
            180                 185                 190         


Tyr Ser Tyr Thr Ile Ile Thr Val Asp Ser Cys Lys Gly Leu Ser Asp 
        195                 200                 205             


Ile His His Arg Met Pro Ala Ile Leu Asp Gly Glu Glu Ala Val Ser 
    210                 215                 220                 


Lys Trp Leu Asp Phe Gly Glu Val Ser Thr Gln Glu Ala Leu Lys Leu 
225                 230                 235                 240 


Ile His Pro Thr Glu Asn Ile Thr Phe His Ala Val Ser Ser Val Val 
                245                 250                 255     


Asn Asn Ser Arg Asn Asn Thr Pro Glu Cys Leu Ala Pro Val Asp Leu 
            260                 265                 270         


Val Val Lys Lys Glu Leu Arg Ala Ser Gly Ser Ser Gln Arg Met Leu 
        275                 280                 285             


Gln Trp Leu Ala Thr Lys Ser Pro Lys Lys Glu Asp Ser Lys Thr Pro 
    290                 295                 300                 


Gln Lys Glu Glu Ser Asp Val Pro Gln Trp Ser Ser Gln Phe Leu Gln 
305                 310                 315                 320 


Lys Ser Pro Leu Pro Thr Lys Arg Gly Thr Ala Gly Leu Leu Glu Gln 
                325                 330                 335     


Trp Leu Lys Arg Glu Lys Glu Glu Glu Pro Val Ala Lys Arg Pro Tyr 
            340                 345                 350         


Ser Gln 
        


<210>  4
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Asp Lys Asp Asp Ile Glu Thr Pro Leu Leu Thr Glu Ala Ala 
1               5                   10                  15      


Pro Ile Leu Glu Asp Gly Asn Cys Glu Pro Ala Lys Asn Ser Glu Ser 
            20                  25                  30          


Val Asp Gln Gly Ala Lys Pro Glu Ser Lys Ser Glu Pro Val Val Ser 
        35                  40                  45              


Thr Arg Lys Arg Pro Glu Thr Lys Pro Ser Ser Asp Leu Glu Thr Ser 
    50                  55                  60                  


Lys Val Leu Pro Ile Gln Asp Asn Val Ser Lys Asp Val Pro Gln Thr 
65                  70                  75                  80  


Arg Trp Gly Tyr Trp Gly Ser Trp Gly Lys Ser Ile Leu Ser Ser Ala 
                85                  90                  95      


Ser Ala Thr Val Ala Thr Val Gly Gln Gly Ile Ser Asn Val Ile Glu 
            100                 105                 110         


Lys Ala Glu Thr Ser Leu Gly Ile Pro Ser Pro Ser Glu Ile Ser Thr 
        115                 120                 125             


Glu Val Lys Tyr Val Ala Gly Glu Thr Asn Ala Lys Glu Asn Glu Asn 
    130                 135                 140                 


Ser Ser Pro Val Ala Gly Ala Phe Gly Val Phe Ser Thr Ile Ser Thr 
145                 150                 155                 160 


Ala Val Gln Ser Thr Gly Lys Ser Val Ile Ser Gly Gly Leu Asp Ala 
                165                 170                 175     


Leu Glu Phe Ile Gly Lys Lys Thr Met Asp Val Ile Ala Glu Gly Asp 
            180                 185                 190         


Pro Gly Phe Lys Arg Thr Lys Gly Leu Met Asn Arg Asn Ala Thr Leu 
        195                 200                 205             


Ser Gln Val Leu Arg Glu Ala Lys Glu Lys Glu Glu Ile Arg Thr Ser 
    210                 215                 220                 


Asn Glu Val Thr Val Glu Thr Asp Lys Lys Thr His Tyr Gly Leu Leu 
225                 230                 235                 240 


Phe Asp Glu Phe Gln Gly Leu Ser His Leu Glu Ala Leu Glu Met Leu 
                245                 250                 255     


Ser Gln Glu Ser Glu Ile Lys Val Lys Ser Ile Leu Asn Ser Leu Ser 
            260                 265                 270         


Gly Glu Glu Leu Glu Thr Leu Lys Val Glu Leu Glu Gln Leu Lys Glu 
        275                 280                 285             


Thr Phe Ser Leu Ala Glu Phe Cys Glu Glu Glu Glu Glu Glu Lys Lys 
    290                 295                 300                 


Gly Asp Glu Asp Phe Thr Lys Asp Ile Thr Glu Leu Phe Ser Gln Leu 
305                 310                 315                 320 


His Val Ser Ser Lys Pro Glu Lys Leu Ala Arg Ala Arg Asn Thr Ala 
                325                 330                 335     


His Glu Trp Ile Arg Lys Ser Leu Thr Lys Pro Leu Ala Glu Asn Glu 
            340                 345                 350         


Glu Gly Glu Lys Gln Ser Glu Ala Glu Asn Thr Glu Gln Val Asn Lys 
        355                 360                 365             


Asn Ser Ile Glu Asp Ile His Ala Phe Ala Ile Arg Ser Leu Ala Glu 
    370                 375                 380                 


Leu Thr Ala Cys Ser Ile Glu Leu Phe His Lys Thr Ala Ala Leu Val 
385                 390                 395                 400 


Leu His Gly Arg Lys Gln Glu Val Thr Ala Ile Glu Arg Ser Gln Thr 
                405                 410                 415     


Leu Ser Gln Met Thr Ile Val Leu Cys Lys Glu Leu Ser Ser Leu Ser 
            420                 425                 430         


Lys Glu Phe Thr Thr Cys Leu Thr Thr Ala Gly Val Lys Glu Met Ala 
        435                 440                 445             


Asp Val Leu Asn Pro Leu Ile Thr Ala Val Phe Leu Glu Ala Ser Asn 
    450                 455                 460                 


Ser Ala Ser Tyr Ile Gln Asp Ala Phe Gln Leu Leu Leu Pro Val Leu 
465                 470                 475                 480 


Glu Ile Ser Leu Ile Glu Asn Lys Ile Glu Ser His Arg His Glu Leu 
                485                 490                 495     


Gln Gly Gln Lys Pro Leu Leu Glu His 
            500                 505 


<210>  5
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Arg Gly Ser Gly Ala Phe Ser Leu Glu Thr Ile Ala Glu Ser Ser 
1               5                   10                  15      


Ala Gln Ser Pro Gly Cys Gln Leu Leu Val Glu Thr Leu Gly Val Pro 
            20                  25                  30          


Leu Gln Glu Ala Thr Glu Leu Gly Asp Pro Thr Gln Ala Asp Ser Ala 
        35                  40                  45              


Arg Pro Glu Gln Ser Ser Gln Ser Pro Val Gln Ala Val Pro Gly Ser 
    50                  55                  60                  


Gly Asp Ser Gln Pro Asp Asp Pro Pro Asp Arg Gly Thr Gly Leu Ser 
65                  70                  75                  80  


Ala Ser Gln Arg Ala Ser Gln Asp His Leu Ser Glu Gln Gly Ala Asp 
                85                  90                  95      


Asp Ser Lys Pro Glu Thr Asp Arg Val Pro Gly Asp Gly Gly Gln Lys 
            100                 105                 110         


Glu His Leu Pro Ser Ile Asp Ser Glu Gly Glu Lys Pro Asp Arg Gly 
        115                 120                 125             


Ala Pro Gln Glu Gly Gly Ala Gln Arg Thr Ala Gly Ala Gly Leu Pro 
    130                 135                 140                 


Arg Gly Pro Gln Glu Glu Gly Asp Gly Val Pro Cys Thr Pro Ala Ser 
145                 150                 155                 160 


Ala Pro Thr Ser Gly Pro Ala Pro Gly Leu Gly Pro Ala Ser Trp Cys 
                165                 170                 175     


Leu Glu Pro Gly Ser Val Ala Gln Gly Ser Pro Asp Pro Gln Gln Thr 
            180                 185                 190         


Pro Ser Arg Met Gly Arg Glu Gly Glu Gly Thr His Ser Ser Leu Gly 
        195                 200                 205             


Cys Ser Ser Leu Gly Met Val Val Ile Ala Asp Leu Ser Thr Asp Pro 
    210                 215                 220                 


Thr Glu Leu Glu Glu Arg Ala Leu Glu Val Ala Gly Pro Asp Gly Gln 
225                 230                 235                 240 


Ala Ser Ala Ile Ser Pro Ala Ser Pro Arg Arg Lys Ala Ala Asp Gly 
                245                 250                 255     


Gly His Arg Arg Ala Leu Pro Gly Cys Thr Ser Leu Thr Gly Glu Thr 
            260                 265                 270         


Thr Gly Glu Ser Gly Glu Ala Gly Gln Asp Gly Lys Pro Pro Gly Asp 
        275                 280                 285             


Val Leu Val Gly Pro Thr Ala Ser Leu Ala Leu Ala Pro Gly Ser Gly 
    290                 295                 300                 


Glu Ser Met Met Gly Ala Gly Asp Ser Gly His Ala Ser Pro Asp Thr 
305                 310                 315                 320 


Gly Pro Cys Val Asn Gln Lys Gln Glu Pro Gly Pro Ala Gln Glu Glu 
                325                 330                 335     


Ala Glu Leu Gly Gly Gln Asn Leu Glu Arg Asp Leu Glu Gly Phe Arg 
            340                 345                 350         


Val Ser Pro Gln Ala Ser Val Val Leu Glu His Arg Glu Ile Ala Asp 
        355                 360                 365             


Asp Pro Leu Gln Glu Pro Gly Ala Gln Arg Gly Ile Pro Asp Thr Thr 
    370                 375                 380                 


Ser Glu Leu Ala Gly Gln Arg Asp His Leu Pro His Ser Ala Asp Gln 
385                 390                 395                 400 


Gly Thr Trp Ala Asp Ser Leu Ala Val Glu Leu Asp Phe Leu Leu Asp 
                405                 410                 415     


Ser Gln Ile Gln Asp Ala Leu Asp Ala Ser Asp Phe Glu Ala Pro Pro 
            420                 425                 430         


Glu Gln Leu Phe Pro Ser Gly Asn Lys Pro Gly Pro Cys Trp Pro Gly 
        435                 440                 445             


Pro Ser Ser His Ala Asn Gly Asp Pro Val Ala Val Ala Lys Ala Gln 
    450                 455                 460                 


Pro Arg Thr Phe Val Gly Ile Gln Ala Ser Glu Ala Ser Arg Met Glu 
465                 470                 475                 480 


Asp Ala Thr Asn Val Val Arg Gly Leu Ile Val Glu Leu Ser Asn Leu 
                485                 490                 495     


Asn Arg Leu Ile Met Gly Thr His Arg Asp Leu Glu Ala Phe Lys Arg 
            500                 505                 510         


Leu Asn Tyr Arg Lys Thr Lys Leu Gly Gly Lys Ala Pro Leu Pro Tyr 
        515                 520                 525             


Pro Ser Lys Gly Pro Gly Asn Ile Pro Arg Gly Asp Pro Pro Trp Arg 
    530                 535                 540                 


Glu Leu 
545     


<210>  6
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Pro Lys Ala Ser Cys Pro Ala Ala Ala Pro Leu Met Glu Arg 
1               5                   10                  15      


Lys Phe His Val Leu Val Gly Val Thr Gly Ser Val Ala Ala Leu Lys 
            20                  25                  30          


Leu Pro Leu Leu Val Ser Lys Leu Leu Asp Ile Pro Gly Leu Glu Val 
        35                  40                  45              


Ala Val Val Thr Thr Glu Arg Ala Lys His Phe Tyr Ser Pro Gln Asp 
    50                  55                  60                  


Ile Pro Val Thr Leu Tyr Ser Asp Ala Asp Glu Trp Glu Met Trp Lys 
65                  70                  75                  80  


Ser Arg Ser Asp Pro Val Leu His Ile Asp Leu Arg Arg Trp Ala Asp 
                85                  90                  95      


Leu Leu Leu Val Ala Pro Leu Asp Ala Asn Thr Leu Gly Lys Val Ala 
            100                 105                 110         


Ser Gly Ile Cys Asp Asn Leu Leu Thr Cys Val Met Arg Ala Trp Asp 
        115                 120                 125             


Arg Ser Lys Pro Leu Leu Phe Cys Pro Ala Met Asn Thr Ala Met Trp 
    130                 135                 140                 


Glu His Pro Ile Thr Ala Gln Gln Val Asp Gln Leu Lys Ala Phe Gly 
145                 150                 155                 160 


Tyr Val Glu Ile Pro Cys Val Ala Lys Lys Leu Val Cys Gly Asp Glu 
                165                 170                 175     


Gly Leu Gly Ala Met Ala Glu Val Gly Thr Ile Val Asp Lys Val Lys 
            180                 185                 190         


Glu Val Leu Phe Gln His Ser Gly Phe Gln Gln Ser 
        195                 200                 


<210>  7
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Glu Lys Thr Lys Lys Ala Glu Glu Met Ala Leu Ser Leu Thr 
1               5                   10                  15      


Arg Ala Val Ala Gly Gly Asp Glu Gln Val Ala Met Lys Cys Ala Ile 
            20                  25                  30          


Trp Leu Ala Glu Gln Arg Val Pro Leu Ser Val Gln Leu Lys Pro Glu 
        35                  40                  45              


Val Ser Pro Thr Gln Asp Ile Arg Leu Trp Val Ser Val Glu Asp Ala 
    50                  55                  60                  


Gln Met His Thr Val Thr Ile Trp Leu Thr Val Arg Pro Asp Met Thr 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asp Met Val Phe Leu Asp Tyr Gly Phe Pro Pro 
                85                  90                  95      


Val Leu Gln Gln Trp Val Ile Gly Gln Arg Leu Ala Arg Asp Gln Glu 
            100                 105                 110         


Thr Leu His Ser His Gly Val Arg Gln Asn Gly Asp Ser Ala Tyr Leu 
        115                 120                 125             


Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu Asn Pro Gln Glu Leu Gln 
    130                 135                 140                 


Arg Glu Arg Gln Leu Arg Met Leu Glu Asp Leu Gly Phe Lys Asp Leu 
145                 150                 155                 160 


Thr Leu Gln Pro Arg Gly Pro Leu Glu Pro Gly Pro Pro Lys Pro Gly 
                165                 170                 175     


Val Pro Gln Glu Pro Gly Arg Gly Gln Pro Asp Ala Val Pro Glu Pro 
            180                 185                 190         


Pro Pro Val Gly Trp Gln Cys Pro Gly Cys Thr Phe Ile Asn Lys Pro 
        195                 200                 205             


Thr Arg Pro Gly Cys Glu Met Cys Cys Arg Ala Arg Pro Glu Ala Tyr 
    210                 215                 220                 


Gln Val Pro Ala Ser Tyr Gln Pro Asp Glu Glu Glu Arg Ala Arg Leu 
225                 230                 235                 240 


Ala Gly Glu Glu Glu Ala Leu Arg Gln Tyr Gln Gln Arg Lys Gln Gln 
                245                 250                 255     


Gln Gln Glu Gly Asn Tyr Leu Gln His Val Gln Leu Asp Gln Arg Ser 
            260                 265                 270         


Leu Val Leu Asn Thr Glu Pro Ala Glu Cys Pro Val Cys Tyr Ser Val 
        275                 280                 285             


Leu Ala Pro Gly Glu Ala Val Val Leu Arg Glu Cys Leu His Thr Phe 
    290                 295                 300                 


Cys Arg Glu Cys Leu Gln Gly Thr Ile Arg Asn Ser Gln Glu Ala Glu 
305                 310                 315                 320 


Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr Ser Cys Ser Gly Lys Leu 
                325                 330                 335     


Leu Glu Arg Glu Ile Lys Ala Leu Leu Thr Pro Glu Asp Tyr Gln Arg 
            340                 345                 350         


Phe Leu Asp Leu Gly Ile Ser Ile Ala Glu Asn Arg Ser Ala Phe Ser 
        355                 360                 365             


Tyr His Cys Lys Thr Pro Asp Cys Lys Gly Trp Cys Phe Phe Glu Asp 
    370                 375                 380                 


Asp Val Asn Glu Phe Thr Cys Pro Val Cys Phe His Val Asn Cys Leu 
385                 390                 395                 400 


Leu Cys Lys Ala Ile His Glu Gln Met Asn Cys Lys Glu Tyr Gln Glu 
                405                 410                 415     


Asp Leu Ala Leu Arg Ala Gln Asn Asp Val Ala Ala Arg Gln Thr Thr 
            420                 425                 430         


Glu Met Leu Lys Val Met Leu Gln Gln Gly Glu Ala Met Arg Cys Pro 
        435                 440                 445             


Gln Cys Gln Ile Val Val Gln Lys Lys Asp Gly Cys Asp Trp Ile Arg 
    450                 455                 460                 


Cys Thr Val Cys His Thr Glu Ile Cys Trp Val Thr Lys Gly Pro Arg 
465                 470                 475                 480 


Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser Gly Gly Cys Arg Cys Arg 
                485                 490                 495     


Val Asn Gly Ile Pro Cys His Pro Ser Cys Gln Asn Cys His 
            500                 505                 510 


<210>  8
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Leu Lys Lys Ser Ser Pro Ser Leu Asp Ser Gly Asp Ser Asp 
1               5                   10                  15      


Ser Glu Glu Leu Pro Thr Phe Ala Phe Leu Lys Lys Glu Pro Ser Ser 
            20                  25                  30          


Thr Lys Arg Arg Gln Pro Glu Arg Glu Glu Lys Ile Val Val Val Asp 
        35                  40                  45              


Ile Ser Asp Cys Glu Ala Ser Cys Pro Pro Ala Pro Glu Leu Phe Ser 
    50                  55                  60                  


Pro Pro Val Pro Asp Ile Ala Glu Thr Val Thr Gln Thr Gln Pro Val 
65                  70                  75                  80  


Arg Leu Leu Ser Ser Glu Ser Glu Asp Glu Glu Glu Phe Ile Pro Leu 
                85                  90                  95      


Ala Gln Arg Leu Thr Cys Lys Phe Leu Thr His Lys Gln Leu Ser Pro 
            100                 105                 110         


Glu Asp Ser Ser Ser Pro Val Lys Ser Val Leu Asp His Gln Asn Asn 
        115                 120                 125             


Glu Gly Ala Ser Cys Asp Trp Lys Lys Pro Phe Pro Lys Ile Pro Glu 
    130                 135                 140                 


Val Pro Leu His Asp Thr Pro Glu Arg Ser Ala Ala Asp Asn Lys Asp 
145                 150                 155                 160 


Leu Ile Leu Asp Pro Cys Cys Gln Leu Pro Ala Tyr Leu Ser Thr Cys 
                165                 170                 175     


Pro Gly Gln Ser Ser Ser Leu Ala Val Thr Lys Thr Asn Ser Asp Ile 
            180                 185                 190         


Leu Pro Pro Gln Lys Lys Thr Lys Pro Ser Gln Lys Val Gln Gly Arg 
        195                 200                 205             


Gly Ser His Gly Cys Arg Gln Gln Arg Gln Ala Arg Gln Lys Glu Ser 
    210                 215                 220                 


Thr Leu Arg Arg Gln Glu Arg Lys Asn Ala Ala Leu Val Thr Arg Met 
225                 230                 235                 240 


Lys Ala Gln Arg Pro Glu Glu Cys Leu Lys His Ile Ile Val Val Leu 
                245                 250                 255     


Asp Pro Val Leu Leu Gln Met Glu Gly Gly Gly Gln Leu Leu Gly Ala 
            260                 265                 270         


Leu Gln Thr Met Glu Cys Arg Cys Val Ile Glu Ala Gln Ala Val Pro 
        275                 280                 285             


Cys Ser Val Thr Trp Arg Arg Arg Ala Gly Pro Ser Glu Asp Arg Glu 
    290                 295                 300                 


Asp Trp Val Glu Glu Pro Thr Val Leu Val Leu Leu Arg Ala Glu Ala 
305                 310                 315                 320 


Phe Val Ser Met Ile Asp Asn Gly Lys Gln Gly Ser Leu Asp Ser Thr 
                325                 330                 335     


Met Lys Gly Lys Glu Thr Leu Gln Gly Phe Val Thr Asp Ile Thr Ala 
            340                 345                 350         


Lys Thr Ala Gly Lys Ala Leu Ser Leu Val Ile Val Asp Gln Glu Lys 
        355                 360                 365             


Cys Phe Ser Leu Glu Leu Leu Phe Phe Asp Phe Leu Pro Cys Thr Ser 
    370                 375                 380                 


Ala Gln Asn Pro Pro Arg Arg Gly Lys Gln Gly Ala Asn Lys Gln Thr 
385                 390                 395                 400 


Lys Lys Gln Gln Gln Arg Gln Pro Glu Ala Ser Ile Gly Ser Met Val 
                405                 410                 415     


Ser Arg Val Asp Ala Glu Glu Ala Leu Val Asp Leu Gln Leu His Thr 
            420                 425                 430         


Glu Ala Gln Ala Gln Ile Val Gln Ser Trp Lys Glu Leu Ala Asp Phe 
        435                 440                 445             


Thr Cys Ala Phe Thr Lys Ala Val Ala Glu Ala Pro Phe Lys Lys Leu 
    450                 455                 460                 


Arg Asp Glu Thr Thr Phe Ser Phe Cys Leu Glu Ser Asp Trp Ala Gly 
465                 470                 475                 480 


Gly Val Lys Val Asp Leu Ala Gly Arg Gly Leu Ala Leu Val Trp Arg 
                485                 490                 495     


Arg Gln Ile Gln Gln Leu Asn Arg Val Ser Leu Glu Met Ala Ser Ala 
            500                 505                 510         


Val Val Asn Ala Tyr Pro Ser Pro Gln Leu Leu Val Gln Ala Tyr Gln 
        515                 520                 525             


Gln Cys Phe Ser Asp Lys Glu Arg Gln Asn Leu Leu Ala Asp Ile Gln 
    530                 535                 540                 


Val Arg Arg Gly Glu Gly Val Thr Ser Thr Ser Arg Arg Ile Gly Pro 
545                 550                 555                 560 


Glu Leu Ser Arg Arg Ile Tyr Leu Gln Met Thr Thr Leu Gln Pro His 
                565                 570                 575     


Leu Ser Leu Asp Ser Ala Asp 
            580             


<210>  9
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Gln Gly Val Gly Pro Gly Pro Gly Ser Ala Ala Pro Pro 
1               5                   10                  15      


Gly Leu Glu Ala Ala Arg Gln Lys Leu Ala Leu Arg Arg Lys Lys Val 
            20                  25                  30          


Leu Ser Thr Glu Glu Met Glu Leu Tyr Glu Leu Ala Gln Ala Ala Gly 
        35                  40                  45              


Gly Gly Ile Asp Pro Asp Val Phe Lys Ile Leu Val Asp Leu Leu Lys 
    50                  55                  60                  


Leu Asn Val Ala Pro Leu Ala Val Phe Gln Met Leu Lys Ser Met Cys 
65                  70                  75                  80  


Ala Gly Gln Arg Leu Ala Ser Glu Pro Gln Asp Pro Ala Ala Val Ser 
                85                  90                  95      


Leu Pro Thr Ser Ser Val Pro Glu Thr Arg Gly Arg Asp Lys Gly Ser 
            100                 105                 110         


Ala Ala Leu Gly Gly Val Leu Ala Leu Ala Glu Arg Ser Asn His Glu 
        115                 120                 125             


Gly Ser Ser Gln Arg Met Pro Arg Gln Pro Ser Ala Thr Arg Leu Pro 
    130                 135                 140                 


Lys Gly Gly Gly Pro Gly Lys Ser Pro Thr Gln Gly Ser Thr 
145                 150                 155             


<210>  10
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  11
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Arg Ala Cys Val Ala Ala Ala Cys Thr Val Ala Ala Arg Cys Pro 
1               5                   10                  15      


Gly Arg Gly Val Gly Asp Arg Ser Gln Ser Gly Ala Ser Tyr Arg Pro 
            20                  25                  30          


Ile Cys Gly Pro Lys Val Gly Gly Pro Thr Glu Met Leu Arg Gly Met 
        35                  40                  45              


Tyr Leu Thr Arg Asn Gly Asn Leu Gln Arg Arg His Thr Met Lys Glu 
    50                  55                  60                  


Ala Lys Asp Met Lys Asn Lys Leu Gly Ile Phe Arg Arg Arg Asn Glu 
65                  70                  75                  80  


Ser Pro Gly Ala Pro Pro Ala Gly Lys Ala Asp Lys Met Met Lys Ser 
                85                  90                  95      


Phe Lys Pro Thr Ser Glu Glu Ala Leu Lys Trp Gly Glu Ser Leu Glu 
            100                 105                 110         


Lys Leu Leu Val His Lys Tyr Gly Leu Ala Val Phe Gln Ala Phe Leu 
        115                 120                 125             


Arg Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu Ala Cys Glu 
    130                 135                 140                 


Asp Phe Lys Lys Val Lys Ser Gln Ser Lys Met Ala Ser Lys Ala Lys 
145                 150                 155                 160 


Lys Ile Phe Ala Glu Tyr Ile Ala Ile Gln Ala Cys Lys Glu Val Asn 
                165                 170                 175     


Leu Asp Ser Tyr Thr Arg Glu His Thr Lys Asp Asn Leu Gln Ser Val 
            180                 185                 190         


Thr Arg Gly Cys Phe Asp Leu Ala Gln Lys Arg Ile Phe Gly Leu Met 
        195                 200                 205             


Glu Lys Asp Ser Tyr Pro Arg Phe Leu Arg Ser Asp Leu Tyr Leu Asp 
    210                 215                 220                 


Leu Ile Asn Gln Lys Lys Met Ser Pro Pro Leu 
225                 230                 235 


<210>  12
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Leu Glu Leu Glu Leu Cys Pro Gly Arg Trp Val Gly Gly Gln 
1               5                   10                  15      


His Pro Cys Phe Ile Ile Ala Glu Ile Gly Gln Asn His Gln Gly Asp 
            20                  25                  30          


Leu Asp Val Ala Lys Arg Met Ile Arg Met Ala Lys Glu Cys Gly Ala 
        35                  40                  45              


Asp Cys Ala Lys Phe Gln Lys Ser Glu Leu Glu Phe Lys Phe Asn Arg 
    50                  55                  60                  


Lys Ala Leu Asp Arg Pro Tyr Thr Ser Lys His Ser Trp Gly Lys Thr 
65                  70                  75                  80  


Tyr Gly Glu His Lys Arg His Leu Glu Phe Ser His Asp Gln Tyr Arg 
                85                  90                  95      


Glu Leu Gln Arg Tyr Ala Glu Glu Val Gly Ile Phe Phe Thr Ala Ser 
            100                 105                 110         


Gly Met Asp Glu Met Ala Val Glu Phe Leu His Glu Leu Asn Val Pro 
        115                 120                 125             


Phe Phe Lys Val Gly Ser Gly Asp Thr Asn Asn Phe Pro Tyr Leu Glu 
    130                 135                 140                 


Lys Thr Ala Lys Lys Gly Arg Pro Met Val Ile Ser Ser Gly Met Gln 
145                 150                 155                 160 


Ser Met Asp Thr Met Lys Gln Val Tyr Gln Ile Val Lys Pro Leu Asn 
                165                 170                 175     


Pro Asn Phe Cys Phe Leu Gln Cys Thr Ser Ala Tyr Pro Leu Gln Pro 
            180                 185                 190         


Glu Asp Val Asn Leu Arg Val Ile Ser Glu Tyr Gln Lys Leu Phe Pro 
        195                 200                 205             


Asp Ile Pro Ile Gly Tyr Ser Gly His Glu Thr Gly Ile Ala Ile Ser 
    210                 215                 220                 


Val Ala Ala Val Ala Leu Gly Ala Lys Val Leu Glu Arg His Ile Thr 
225                 230                 235                 240 


Leu Asp Lys Thr Trp Lys Gly Ser Asp His Ser Ala Ser Leu Glu Pro 
                245                 250                 255     


Gly Glu Leu Ala Glu Leu Val Arg Ser Val Arg Leu Val Glu Arg Ala 
            260                 265                 270         


Leu Gly Ser Pro Thr Lys Gln Leu Leu Pro Cys Glu Met Ala Cys Asn 
        275                 280                 285             


Glu Lys Leu Gly Lys Ser Val Val Ala Lys Val Lys Ile Pro Glu Gly 
    290                 295                 300                 


Thr Ile Leu Thr Met Asp Met Leu Thr Val Lys Val Gly Glu Pro Lys 
305                 310                 315                 320 


Gly Tyr Pro Pro Glu Asp Ile Phe Asn Leu Val Gly Lys Lys Val Leu 
                325                 330                 335     


Val Thr Val Glu Glu Asp Asp Thr Ile Met Glu Glu Leu Val Asp Asn 
            340                 345                 350         


His Gly Lys Lys Ile Lys Ser 
        355                 


<210>  13
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Cys Met Asp Pro Lys Cys Glu Lys Leu Ala Ile Thr Arg Ser Leu 
1               5                   10                  15      


Ala Ser Ala Gln Ser Leu Ser Tyr His Gln Asn Gln Gly His Arg Gly 
            20                  25                  30          


Arg Leu Thr Ala Ser Leu Asn Thr Leu Arg Glu Ala Asp Leu Gly Gln 
        35                  40                  45              


Val Thr Arg Val Tyr Lys Ser Gln Asp Ser Arg Leu Gly Leu Val His 
    50                  55                  60                  


Gly Arg Thr Asp Glu Gln Leu His Ser Cys Ser Arg Thr Asp Gln Asp 
65                  70                  75                  80  


Lys Ala Met Leu Glu Leu Gly Pro His Ile Cys 
                85                  90      


<210>  14
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Val Thr Asp Gln Ala Phe Val Thr Leu Ala Thr Asn Asp Ile 
1               5                   10                  15      


Tyr Cys Gln Gly Ala Leu Val Leu Gly Gln Ser Leu Arg Arg His Arg 
            20                  25                  30          


Leu Thr Arg Lys Leu Val Val Leu Ile Thr Pro Gln Val Ser Ser Leu 
        35                  40                  45              


Leu Arg Val Ile Leu Ser Lys Val Phe Asp Glu Val Ile Glu Val Asn 
    50                  55                  60                  


Leu Ile Asp Ser Ala Asp Tyr Ile His Leu Ala Phe Leu Lys Arg Pro 
65                  70                  75                  80  


Glu Leu Gly Leu Thr Leu Thr Lys Leu His Cys Trp Thr Leu Thr His 
                85                  90                  95      


Tyr Ser Lys Cys Val Phe Leu Asp Ala Asp Thr Leu Val Leu Ser Asn 
            100                 105                 110         


Val Asp Glu Leu Phe Asp Arg Gly Glu Phe Ser Ala Ala Pro Asp Pro 
        115                 120                 125             


Gly Trp Pro Asp Cys Phe Asn Ser Gly Val Phe Val Phe Gln Pro Ser 
    130                 135                 140                 


Leu His Thr His Lys Leu Leu Leu Gln His Ala Met Glu His Gly Ser 
145                 150                 155                 160 


Phe Asp Gly Ala Asp Gln Gly Leu Leu Asn Ser Phe Phe Arg Asn Trp 
                165                 170                 175     


Ser Thr Thr Asp Ile His Lys His Leu Pro Phe Ile Tyr Asn Leu Ser 
            180                 185                 190         


Ser Asn Thr Met Tyr Thr Tyr Ser Pro Ala Phe Lys Gln Phe Gly Ser 
        195                 200                 205             


Ser Ala Lys Val Val His Phe Leu Gly Ser Met Lys Pro Trp Asn Tyr 
    210                 215                 220                 


Lys Tyr Asn Pro Gln Ser Gly Ser Val Leu Glu Gln Gly Ser Val Ser 
225                 230                 235                 240 


Ser Ser Gln His Gln Ala Ala Phe Leu His Leu Trp Trp Thr Val Tyr 
                245                 250                 255     


Gln Asn Asn Val Leu Pro Leu Tyr Lys Ser Val Gln Ala Gly Glu Ala 
            260                 265                 270         


Arg Ala Ser Pro Gly His Thr Leu Cys Arg Ser Asp Val Gly Gly Pro 
        275                 280                 285             


Cys Ala Asp Ser Ala Ser Gly Val Gly Glu Pro Cys Glu Asn Ser Thr 
    290                 295                 300                 


Pro Ser Ala Gly Val Pro Cys Ala Asn Ser Pro Leu Gly Ser Asn Gln 
305                 310                 315                 320 


Pro Ala Gln Gly Leu Pro Glu Pro Thr Gln Ile Val Asp Glu Thr Leu 
                325                 330                 335     


Ser Leu Pro Glu Gly Arg Arg Ser Glu Asp Met Ile Ala Cys Pro Glu 
            340                 345                 350         


Thr Glu Thr Pro Ala Val Ile Thr Cys Asp Pro Leu Ser Gln Pro Ser 
        355                 360                 365             


Pro Gln Pro Ala Asp Phe Thr Glu Thr Glu Thr Ile Leu Gln Pro Ala 
    370                 375                 380                 


Asn Lys Val Glu Ser Val Ser Ser Glu Glu Thr Phe Glu Pro Ser Gln 
385                 390                 395                 400 


Glu Leu Pro Ala Glu Ala Leu Arg Asp Pro Ser Leu Gln Asp Ala Leu 
                405                 410                 415     


Glu Val Asp Leu Ala Val Ser Val Ser Gln Ile Ser Ile Glu Glu Lys 
            420                 425                 430         


Val Lys Glu Leu Ser Pro Glu Glu Glu Arg Arg Lys Trp Glu Glu Gly 
        435                 440                 445             


Arg Ile Asp Tyr Met Gly Lys Asp Ala Phe Ala Arg Ile Gln Glu Lys 
    450                 455                 460                 


Leu Asp Arg Phe Leu Gln 
465                 470 


<210>  15
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu 
1               5                   10                  15      


Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Thr Ala Pro Gly Cys 
            20                  25                  30          


Gly Gln Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys 
        35                  40                  45              


His Glu Met Thr Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile 
    50                  55                  60                  


Val Ala Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu 
65                  70                  75                  80  


Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe 
                85                  90                  95      


Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser 
            100                 105                 110         


Pro Leu Ala Thr Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val 
        115                 120                 125             


Val Glu Thr Thr His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Thr 
    130                 135                 140                 


Thr Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Thr Ala Gln Pro Thr 
145                 150                 155                 160 


Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu 
                165                 170                 175     


Thr Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro 
            180                 185                 190         


Thr Ser Ser Thr Val Ile Thr Gln Ala Pro Ser Ser Asn Arg Pro Ile 
        195                 200                 205             


Val 
    


<210>  16
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Asn Gln Leu Asp Arg Ile Thr His Leu Asn Tyr Ser Glu Leu 
1               5                   10                  15      


Pro Thr Gly Asp Pro Ser Gly Ile Glu Lys Asp Glu Leu Arg Val Gly 
            20                  25                  30          


Val Ala Tyr Phe Phe Ser Asp Asp Glu Glu Asp Leu Asp Glu Arg Gly 
        35                  40                  45              


Gln Pro Asp Lys Phe Gly Val Lys Ala Pro Pro Gly Cys Thr Pro Cys 
    50                  55                  60                  


Pro Glu Ser Pro Ser Arg His His His His Leu Leu His Gln Leu Val 
65                  70                  75                  80  


Leu Asn Glu Thr Gln Phe Ser Ala Phe Arg Gly Gln Glu Cys Ile Phe 
                85                  90                  95      


Ser Lys Val Ser Gly Gly Pro Gln Gly Ala Asp Leu Ser Val Tyr Ala 
            100                 105                 110         


Val Thr Ala Leu Pro Ala Leu Cys Glu Pro Gly Asp Leu Leu Glu Leu 
        115                 120                 125             


Leu Trp Leu Gln His Ala Pro Glu Pro Pro Ala Pro Ala Pro His Trp 
    130                 135                 140                 


Ala Val Tyr Val Gly Gly Gly Gln Ile Ile His Leu His Gln Gly Glu 
145                 150                 155                 160 


Ile Arg Gln Asp Ser Leu Tyr Glu Ala Gly Ala Ala Asn Val Gly Arg 
                165                 170                 175     


Val Val Asn Ser Trp Tyr Arg Tyr Arg Pro Leu Val Ala Glu Leu Val 
            180                 185                 190         


Val Gln Asn Ala Cys Gly His Leu Gly Leu Lys Ser Glu Glu Ile Cys 
        195                 200                 205             


Trp Thr Asn Ser Glu Ser Phe Ala Ala Trp Cys Arg Phe Gly Lys Arg 
    210                 215                 220                 


Glu Phe Lys Ala Gly Gly Glu Val Pro Ala Gly Thr Gln Pro Pro Gln 
225                 230                 235                 240 


Gln Gln Tyr Tyr Leu Lys Val His Leu Gly Glu Asn Lys Val His Thr 
                245                 250                 255     


Ala Arg Phe His Ser Leu Glu Asp Leu Ile Arg Glu Lys Arg Arg Ile 
            260                 265                 270         


Asp Ala Ser Gly Arg Leu Arg Val Leu Gln Glu Leu Ala Asp Leu Val 
        275                 280                 285             


Asp Asp Lys Glu 
    290         


<210>  17
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Val Ala Gly Leu Lys Lys Gln Phe His Lys Ala Thr Gln Lys 
1               5                   10                  15      


Val Ser Glu Lys Val Gly Gly Ala Glu Gly Thr Lys Leu Asp Asp Asp 
            20                  25                  30          


Phe Lys Glu Met Glu Arg Lys Val Asp Val Thr Ser Arg Ala Val Met 
        35                  40                  45              


Glu Ile Met Thr Lys Thr Ile Glu Tyr Leu Gln Pro Asn Pro Ala Ser 
    50                  55                  60                  


Arg Ala Lys Leu Ser Met Ile Asn Thr Met Ser Lys Ile Arg Gly Gln 
65                  70                  75                  80  


Glu Lys Gly Pro Gly Tyr Pro Gln Ala Glu Ala Leu Leu Ala Glu Ala 
                85                  90                  95      


Met Leu Lys Phe Gly Arg Glu Leu Gly Asp Asp Cys Asn Phe Gly Pro 
            100                 105                 110         


Ala Leu Gly Glu Val Gly Glu Ala Met Arg Glu Leu Ser Glu Val Lys 
        115                 120                 125             


Asp Ser Leu Asp Ile Glu Val Lys Gln Asn Phe Ile Asp Pro Leu Gln 
    130                 135                 140                 


Asn Leu His Asp Lys Asp Leu Arg Glu Ile Gln His His Leu Lys Lys 
145                 150                 155                 160 


Leu Glu Gly Arg Arg Leu Asp Phe Asp Tyr Lys Lys Glu Arg Gln Gly 
                165                 170                 175     


Lys Ile Pro Asp Glu Glu Leu Arg Gln Ala Leu Glu Lys Phe Asp Glu 
            180                 185                 190         


Ser Lys Glu Ile Ala Glu Ser Ser Met Phe Asn Leu Leu Glu Met Asp 
        195                 200                 205             


Ile Glu Gln Val Ser Gln Leu Ser Ala Leu Val Gln Ala Gln Leu Glu 
    210                 215                 220                 


Tyr His Lys Gln Ala Val Gln Ile Leu Gln Gln Val Thr Val Arg Leu 
225                 230                 235                 240 


Glu Glu Arg Ile Arg Gln Ala Ser Ser Gln Pro Arg Arg Glu Tyr Gln 
                245                 250                 255     


Pro Lys Pro Arg Met Ser Leu Glu Phe Pro Thr Gly Asp Ser Thr Gln 
            260                 265                 270         


Pro Asn Gly Gly Leu Ser His 
        275                 


<210>  18
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Ser Ile Phe His Glu Lys Gln Glu Gly Ser Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ser Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Asp Tyr Arg Thr Phe Leu Gln Gln 
    50                  55                  60                  


Pro Ser Gly Asn Met Asp Asp Ser Gly Phe Phe Ser Ile Gln Val Ile 
65                  70                  75                  80  


Ser Asn Ala Leu Lys Val Trp Gly Leu Glu Leu Ile Leu Phe Asn Ser 
                85                  90                  95      


Pro Glu Tyr Gln Arg Leu Arg Ile Asp Pro Ile Asn Glu Arg Ser Phe 
            100                 105                 110         


Ile Cys Asn Tyr Lys Glu His Trp Phe Thr Val Arg Lys Leu Gly Lys 
        115                 120                 125             


Gln Trp Phe Asn Leu Asn Ser Leu Leu Thr Gly Pro Glu Leu Ile Ser 
    130                 135                 140                 


Asp Thr Tyr Leu Ala Leu Phe Leu Ala Gln Leu Gln Gln Glu Gly Tyr 
145                 150                 155                 160 


Ser Ile Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp Gln 
                165                 170                 175     


Leu Leu Gln Met Ile Arg Val Gln Gln Met His Arg Pro Lys Leu Ile 
            180                 185                 190         


Gly Glu Glu Leu Ala Gln Leu Lys Glu Gln Arg Val His Lys Thr Asp 
        195                 200                 205             


Leu Glu Arg Val Leu Glu Ala Asn Asp Gly Ser Gly Met Leu Asp Glu 
    210                 215                 220                 


Asp Glu Glu Asp Leu Gln Arg Ala Leu Ala Leu Ser Arg Gln Glu Ile 
225                 230                 235                 240 


Asp Met Glu Asp Glu Glu Ala Asp Leu Arg Arg Ala Ile Gln Leu Ser 
                245                 250                 255     


Met Gln Gly Ser Ser Arg Asn Ile Ser Gln Asp Met Thr Gln Thr Ser 
            260                 265                 270         


Gly Thr Asn Leu Thr Ser Glu Glu Leu Arg Lys Arg Arg Glu Ala Tyr 
        275                 280                 285             


Phe Glu Lys Gln Gln Gln Lys Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gly Asp Leu Ser Gly Gln 
305                 310                 315                 320 


Ser Ser His Pro Cys Glu Arg Pro Ala Thr Ser Ser Gly Ala Leu Gly 
                325                 330                 335     


Ser Asp Leu Gly Asp Ala Met Ser Glu Glu Asp Met Leu Gln Ala Ala 
            340                 345                 350         


Val Thr Met Ser Leu Glu Thr Val Arg Asn Asp Leu Lys Thr Glu Gly 
        355                 360                 365             


Lys Lys 
    370 


<210>  19
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Thr Arg Ser Cys Arg Glu Lys Ala Gln Lys Leu Asn Glu Gln 
1               5                   10                  15      


His Gln Leu Ile Leu Ser Lys Leu Leu Arg Glu Glu Asp Asn Lys Tyr 
            20                  25                  30          


Cys Ala Asp Cys Glu Ala Lys Gly Pro Arg Trp Ala Ser Trp Asn Ile 
        35                  40                  45              


Gly Val Phe Ile Cys Ile Arg Cys Ala Gly Ile His Arg Asn Leu Gly 
    50                  55                  60                  


Val His Ile Ser Arg Val Lys Ser Val Asn Leu Asp Gln Trp Thr Ala 
65                  70                  75                  80  


Glu Gln Ile Gln Cys Met Gln Asp Met Gly Asn Thr Lys Ala Arg Leu 
                85                  90                  95      


Leu Tyr Glu Ala Asn Leu Pro Glu Asn Phe Arg Arg Pro Gln Thr Asp 
            100                 105                 110         


Gln Ala Val Glu Phe Phe Ile Arg Asp Lys Tyr Glu Lys Lys Lys Tyr 
        115                 120                 125             


Tyr Asp Lys Asn Ala Ile Ala Ile Thr Asn Ile Ser Ser Ser Asp Ala 
    130                 135                 140                 


Pro Leu Gln Pro Leu Val Ser Ser Pro Ser Leu Gln Ala Ala Val Asp 
145                 150                 155                 160 


Lys Asn Lys Leu Glu Lys Glu Lys Glu Lys Lys Lys Glu Glu Lys Lys 
                165                 170                 175     


Arg Glu Lys Glu Pro Glu Lys Pro Ala Lys Pro Leu Thr Ala Glu Lys 
            180                 185                 190         


Leu Gln Lys Lys Asp Gln Gln Leu Glu Pro Lys Lys Ser Thr Ser Pro 
        195                 200                 205             


Lys Lys Ala Ala Glu Pro Thr Val Asp Leu Leu Gly Leu Asp Gly Pro 
    210                 215                 220                 


Ala Val Ala Pro Val Thr Asn Gly Asn Thr Thr Val Pro Pro Leu Asn 
225                 230                 235                 240 


Asp Asp Leu Asp Ile Phe Gly Pro Met Ile Ser Asn Pro Leu Pro Ala 
                245                 250                 255     


Thr Val Met Pro Pro Ala Gln Gly Thr Pro Ser Ala Pro Ala Ala Ala 
            260                 265                 270         


Thr Leu Ser Thr Val Thr Ser Gly Asp Leu Asp Leu Phe Thr Glu Gln 
        275                 280                 285             


Thr Thr Lys Ser Glu Glu Val Ala Lys Lys Gln Leu Ser Lys Asp Ser 
    290                 295                 300                 


Ile Leu Ser Leu Tyr Gly Thr Gly Thr Ile Gln Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gly Val Phe Met Gly Pro Thr Asn Ile Pro Phe Thr Ser Gln Ala Pro 
                325                 330                 335     


Ala Ala Phe Gln Gly Phe Pro Ser Met Gly Val Pro Val Pro Ala Ala 
            340                 345                 350         


Pro Gly Leu Ile Gly Asn Val Met Gly Gln Ser Pro Ser Met Met Val 
        355                 360                 365             


Gly Met Pro Met Pro Asn Gly Phe Met Gly Asn Ala Gln Thr Gly Val 
    370                 375                 380                 


Met Pro Leu Pro Gln Asn Val Val Gly His Gln Gly Gly Met Val Gly 
385                 390                 395                 400 


Gln Met Gly Ala Pro Gln Ser Lys Phe Gly Leu Pro Gln Ala Gln Gln 
                405                 410                 415     


Pro Gln Trp Ser Leu Ser Gln Met Asn Gln Gln Met Ala Gly Met Ser 
            420                 425                 430         


Ile Ser Ser Ala Thr Pro Thr Ala Gly Phe Gly Gln Pro Ser Ser Thr 
        435                 440                 445             


Thr Ala Gly Trp Ser Gly Ser Ser Ser Gly Gln Thr Leu Ser Thr Gln 
    450                 455                 460                 


Leu Trp Lys 
465         


<210>  20
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Arg Lys Lys Ile Gln Ile Gln Arg Ile Thr Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn His Ser Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ala Asp Ile Ile Glu Thr Leu Arg Lys Lys Gly Phe Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Glu Pro Asp Gly Glu Asp Ser Leu Glu Gln Ser Pro Leu 
            100                 105                 110         


Leu Glu Asp Lys Tyr Arg Arg Ala Ser Glu Glu Leu Asp Gly Leu Phe 
        115                 120                 125             


Arg Arg Tyr Gly Ser Thr Val Pro Ala Pro Asn Phe Ala Met Pro Val 
    130                 135                 140                 


Thr Val Pro Val Ser Asn Gln Ser Ser Leu Gln Phe Ser Asn Pro Ser 
145                 150                 155                 160 


Gly Ser Leu Val Thr Pro Ser Leu Val Thr Ser Ser Leu Thr Asp Pro 
                165                 170                 175     


Arg Leu Leu Ser Pro Gln Gln Pro Ala Leu Gln Arg Asn Ser Val Ser 
            180                 185                 190         


Pro Gly Leu Pro Gln Arg Pro Ala Ser Ala Gly Ala Met Leu Gly Gly 
        195                 200                 205             


Asp Leu Asn Ser Ala Asn Gly Ala Cys Pro Ser Pro Val Gly Asn Gly 
    210                 215                 220                 


Tyr Val Ser Ala Arg Ala Ser Pro Gly Leu Leu Pro Val Ala Asn Gly 
225                 230                 235                 240 


Asn Ser Leu Asn Lys Val Ile Pro Ala Lys Ser Pro Pro Pro Pro Thr 
                245                 250                 255     


His Ser Thr Gln Leu Gly Ala Pro Ser Arg Lys Pro Asp Leu Arg Val 
            260                 265                 270         


Ile Thr Ser Gln Ala Gly Lys Gly Leu Met His His Leu Asn Asn Ala 
        275                 280                 285             


Gln Arg Leu Gly Val Ser Gln Ser Thr His Ser Leu Thr Thr Pro Val 
    290                 295                 300                 


Val Ser Val Ala Thr Pro Ser Leu Leu Ser Gln Gly Leu Pro Phe Ser 
305                 310                 315                 320 


Ser Met Pro Thr Ala Tyr Asn Thr Asp Tyr Gln Leu Thr Ser Ala Glu 
                325                 330                 335     


Leu Ser Ser Leu Pro Ala Phe Ser Ser Pro Gly Gly Leu Ser Leu Gly 
            340                 345                 350         


Asn Val Thr Ala Trp Gln Gln Pro Gln Gln Pro Gln Gln Pro Gln Gln 
        355                 360                 365             


Pro Gln Pro Pro Gln Gln Gln Pro Pro Gln Pro Gln Gln Pro Gln Pro 
    370                 375                 380                 


Gln Gln Pro Gln Gln Pro Gln Gln Pro Pro Gln Gln Gln Ser His Leu 
385                 390                 395                 400 


Val Pro Val Ser Leu Ser Asn Leu Ile Pro Gly Ser Pro Leu Pro His 
                405                 410                 415     


Val Gly Ala Ala Leu Thr Val Thr Thr His Pro His Ile Ser Ile Lys 
            420                 425                 430         


Ser Glu Pro Val Ser Pro Ser Arg Glu Arg Ser Pro Ala Pro Pro Pro 
        435                 440                 445             


Pro Ala Val Phe Pro Ala Ala Arg Pro Glu Pro Gly Asp Gly Leu Ser 
    450                 455                 460                 


Ser Pro Ala Gly Gly Ser Tyr Glu Thr Gly Asp Arg Asp Asp Gly Arg 
465                 470                 475                 480 


Gly Asp Phe Gly Pro Thr Leu Gly Leu Leu Arg Pro Ala Pro Glu Pro 
                485                 490                 495     


Glu Ala Glu Gly Ser Ala Val Lys Arg Met Arg Leu Asp Thr Trp Thr 
            500                 505                 510         


Leu Lys 
        


<210>  21
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Asn Asn Gly Leu Asp Ile Gln Asp Lys Pro Pro Ala Pro Pro 
1               5                   10                  15      


Met Arg Asn Thr Ser Thr Met Ile Gly Ala Gly Ser Lys Asp Ala Gly 
            20                  25                  30          


Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys 
        35                  40                  45              


Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Pro Gly Asp Lys Thr 
    50                  55                  60                  


Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp 
65                  70                  75                  80  


Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe 
                85                  90                  95      


Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile 
            100                 105                 110         


Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu 
        115                 120                 125             


Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser 
    130                 135                 140                 


Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Ala Leu Asn 
145                 150                 155                 160 


Val Lys Ala Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp 
                165                 170                 175     


Glu Asp Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro 
            180                 185                 190         


Arg Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro 
        195                 200                 205             


Leu Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro 
    210                 215                 220                 


Thr Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu 
225                 230                 235                 240 


Lys Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys 
                245                 250                 255     


Leu Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg 
            260                 265                 270         


Phe Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met 
        275                 280                 285             


Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln 
    290                 295                 300                 


Gln Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg 
305                 310                 315                 320 


Glu Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val 
                325                 330                 335     


Gly Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu 
            340                 345                 350         


Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala 
        355                 360                 365             


Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln 
    370                 375                 380                 


Val Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp 
385                 390                 395                 400 


Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro 
                405                 410                 415     


Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala 
            420                 425                 430         


Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile 
        435                 440                 445         


<210>  22
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Arg Leu Gln Lys Gln Pro Leu Thr Ser Pro Gly Ser Val Ser 
1               5                   10                  15      


Pro Ser Arg Asp Ser Ser Val Pro Gly Ser Pro Ser Ser Ile Val Ala 
            20                  25                  30          


Lys Met Asp Asn Gln Val Leu Gly Tyr Lys Asp Leu Ala Ala Ile Pro 
        35                  40                  45              


Lys Asp Lys Ala Ile Leu Asp Ile Glu Arg Pro Asp Leu Met Ile Tyr 
    50                  55                  60                  


Glu Pro His Phe Thr Tyr Ser Leu Leu Glu His Val Glu Leu Pro Arg 
65                  70                  75                  80  


Ser Arg Glu Arg Ser Leu Ser Pro Lys Ser Thr Ser Pro Pro Pro Ser 
                85                  90                  95      


Pro Glu Val Trp Ala Asp Ser Arg Ser Pro Gly Ile Ile Ser Gln Ala 
            100                 105                 110         


Ser Ala Pro Arg Thr Thr Gly Thr Pro Arg Thr Ser Leu Pro His Phe 
        115                 120                 125             


His His Pro Glu Thr Ser Arg Pro Asp Ser Asn Ile Tyr Lys Lys Pro 
    130                 135                 140                 


Pro Ile Tyr Lys Gln Arg Glu Ser Val Gly Gly Ser Pro Gln Thr Lys 
145                 150                 155                 160 


His Leu Ile Glu Asp Leu Ile Ile Glu Ser Ser Lys Phe Pro Ala Ala 
                165                 170                 175     


Gln Pro Pro Asp Pro Asn Gln Pro Ala Lys Ile Glu Thr Asp Tyr Trp 
            180                 185                 190         


Pro Cys Pro Pro Ser Leu Ala Val Val Glu Thr Glu Trp Arg Lys Arg 
        195                 200                 205             


Lys Ala Ser Arg Arg Gly Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp 
    210                 215                 220                 


Asp Ser Gly Glu Glu Met Lys Ala Leu Arg Glu Arg Gln Arg Glu Glu 
225                 230                 235                 240 


Leu Ser Lys Val Thr Ser Asn Leu Gly Lys Met Ile Leu Lys Glu Glu 
                245                 250                 255     


Met Glu Lys Ser Leu Pro Ile Arg Arg Lys Thr Arg Ser Leu Pro Asp 
            260                 265                 270         


Arg Thr Pro Phe His Thr Ser Leu His Gln Gly Thr Ser Lys Ser Ser 
        275                 280                 285             


Ser Leu Pro Ala Tyr Gly Arg Thr Thr Leu Ser Arg Leu Gln Ser Thr 
    290                 295                 300                 


Glu Phe Ser Pro Ser Gly Ser Glu Thr Gly Ser Pro Gly Leu Gln Ile 
305                 310                 315                 320 


Tyr Pro Tyr Glu Met Leu Val Val Thr Asn Lys Gly Arg Thr Lys Leu 
                325                 330                 335     


Pro Pro Gly Val Asp Arg Met Arg Leu Glu Arg His Leu Ser Ala Glu 
            340                 345                 350         


Asp Phe Ser Arg Val Phe Ala Met Ser Pro Glu Glu Phe Gly Lys Leu 
        355                 360                 365             


Ala Leu Trp Lys Arg Asn Glu Leu Lys Lys Lys Ala Ser Leu Phe 
    370                 375                 380             


<210>  23
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ser Arg Ile Tyr His Asp Gly Ala Leu Arg Asn Lys Ala Val Gln 
1               5                   10                  15      


Ser Val Arg Leu Pro Gly Ala Trp Asp Pro Ala Ala His Gln Gly Gly 
            20                  25                  30          


Asn Gly Val Leu Leu Glu Gly Glu Leu Ile Asp Val Ser Arg His Ser 
        35                  40                  45              


Ile Leu Asp Thr His Gly Arg Lys Glu Arg Tyr Tyr Val Leu Tyr Ile 
    50                  55                  60                  


Arg Pro Ser His Ile His Arg Arg Lys Phe Asp Ala Lys Gly Asn Glu 
65                  70                  75                  80  


Ile Glu Pro Asn Phe Ser Ala Thr Arg Lys Val Asn Thr Gly Phe Leu 
                85                  90                  95      


Met Ser Ser Tyr Lys Val Glu Ala Lys Gly Asp Thr Asp Arg Leu Thr 
            100                 105                 110         


Pro Glu Ala Leu Lys Gly Leu Val Asn Lys Pro Glu Leu Leu Ala Leu 
        115                 120                 125             


Thr Glu Ser Leu Thr Pro Asp His Thr Val Ala Phe Trp Met Pro Glu 
    130                 135                 140                 


Ser Glu Met Glu Val Met Glu Leu Glu Leu Gly Ala Gly Val Arg Leu 
145                 150                 155                 160 


Lys Thr Arg Gly Asp Gly Pro Phe Leu Asp Ser Leu Ala Lys Leu Glu 
                165                 170                 175     


Ala Gly Thr Val Thr Lys Cys Asn Phe Thr Gly Asp Gly Lys Thr Gly 
            180                 185                 190         


Ala Ser Trp Thr Asp Asn Ile Met Ala Gln Lys Cys Ser Lys Gly Ala 
        195                 200                 205             


Ala Ala Glu Ile Arg Glu Gln Gly Asp Gly Ala Glu Asp Glu Glu Trp 
    210                 215                 220                 


Asp Asp 
225     


<210>  24
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Pro Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys 
1               5                   10                  15      


Gln Pro His Leu Ala Pro Leu Gln Met Asp Ala Arg Glu Lys Gln Gly 
            20                  25                  30          


Gln Gln Met Arg Glu Ala Gln Phe Leu Tyr Ala Gln Lys Leu Val Thr 
        35                  40                  45              


Gln Pro Thr Leu Leu Ser Ala Thr Ala Gly Arg Pro Ser Gly Ser Thr 
    50                  55                  60                  


Pro Leu Gly Pro Leu Ala Arg Val Pro Pro Thr Ala Ala Val Ala Gln 
65                  70                  75                  80  


Val Phe Glu Arg Gly Asn Met Asn Ser Glu Pro Glu Glu Glu Asp Gly 
                85                  90                  95      


Gly Leu Glu Asp Glu Asp Gly Asp Asp Glu Val Ala Glu Val Ala Glu 
            100                 105                 110         


Lys Glu Thr Gln Ala Ala Ser Lys Tyr Phe His Val Gln Lys Val Ala 
        115                 120                 125             


Arg Gln Asp Pro Arg Val Ala Pro Met Ser Asn Leu Leu Pro Ala Pro 
    130                 135                 140                 


Gly Leu Pro Pro His Gly Gln Gln Ala Lys Glu Asp His Thr Lys Asp 
145                 150                 155                 160 


Ala Ser Lys Ala Ser Pro Ser Val Ser Thr Ala Gly Gln Pro Asn Trp 
                165                 170                 175     


Asn Leu Asp Glu Gln Leu Lys Gln Asn Gly Gly Leu Ala Trp Ser Asp 
            180                 185                 190         


Asp Ala Asp Gly Gly Arg Gly Arg Glu Ile Ser Arg Asp Phe Ala Lys 
        195                 200                 205             


Leu Tyr Glu Leu Asp Gly Asp Pro Glu Arg Lys Glu Phe Leu Asp Asp 
    210                 215                 220                 


Leu Phe Val Phe Met Gln Lys Arg Gly Glu Cys Ala Ser Thr His His 
225                 230                 235                 240 


Ser Asn Ser Gly Asn Thr Asp Arg Val Pro Thr Val Cys 
                245                 250             


<210>  25
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Lys Lys Gln Ala Asn Lys Thr Ala Ser Ser Gly Ser Ser Asp Lys 
1               5                   10                  15      


Asp Ser Ser Ala Glu Ser Ser Ala Pro Glu Glu Gly Glu Val Ser Asp 
            20                  25                  30          


Ser Asp Ser Asn Ser Ser Ser Ser Ser Ser Asp Ser Asp Ser Ser Ser 
        35                  40                  45              


Glu Asp Glu Glu Phe His Asp Gly Tyr Gly Glu Asp Leu Met Gly Asp 
    50                  55                  60                  


Glu Glu Asp Arg Ala Arg Leu Glu Gln Met Thr Glu Lys Glu Arg Glu 
65                  70                  75                  80  


Gln Glu Leu Phe Asn Arg Ile Glu Lys Arg Glu Val Leu Lys Arg Arg 
                85                  90                  95      


Phe Glu Ile Lys Lys Lys Leu Lys Thr Ala Lys Lys Lys Glu Lys Lys 
            100                 105                 110         


Glu Lys Lys Lys Lys Gln Glu Glu Glu Gln Glu Lys Lys Lys Leu Thr 
        115                 120                 125             


Gln Ile Gln Glu Ser Gln Val Thr Ser His Asn Lys Glu Arg Arg Ser 
    130                 135                 140                 


Lys Arg Asp Glu Lys Leu Asp Lys Lys Ser Gln Ala Met Glu Glu Leu 
145                 150                 155                 160 


Lys Ala Glu Arg Glu Lys Arg Lys Asn Arg Thr Ala Glu Leu Leu Ala 
                165                 170                 175     


Lys Lys Gln Pro Leu Lys Thr Ser Glu Val Tyr Ser Asp Asp Glu Glu 
            180                 185                 190         


Glu Glu Glu Asp Asp Lys Ser Ser Glu Lys Ser Asp Arg Ser Ser Arg 
        195                 200                 205             


Thr Ser Ser Ser Asp Glu Glu Glu Glu Lys Glu Glu Ile Pro Pro Lys 
    210                 215                 220                 


Ser Gln Pro Val Ser Leu Pro Glu Glu Leu Asn Arg Val Arg Leu Ser 
225                 230                 235                 240 


Arg His Lys Leu Glu Arg Trp Cys His Met Pro Phe Phe Ala Lys Thr 
                245                 250                 255     


Val Thr Gly Cys Phe Val Arg Ile Gly Ile Gly Asn His Asn Ser Lys 
            260                 265                 270         


Pro Val Tyr Arg Val Ala Glu Ile Thr Gly Val Val Glu Thr Ala Lys 
        275                 280                 285             


Val Tyr Gln Leu Gly Gly Thr Arg Thr Asn Lys Gly Leu Gln Leu Arg 
    290                 295                 300                 


His Gly Asn Asp Gln Arg Val Phe Arg Leu Glu Phe Val Ser Asn Gln 
305                 310                 315                 320 


Glu Phe Thr Glu Ser Glu Phe Met Lys Trp Lys Glu Ala Met Phe Ser 
                325                 330                 335     


Ala Gly Met Gln Leu Pro Thr Leu Asp Glu Ile Asn Lys Lys Glu Leu 
            340                 345                 350         


Ser Ile Lys Glu Ala Leu Asn Tyr Lys Phe Asn Asp Gln Asp Ile Glu 
        355                 360                 365             


Glu Ile Val Lys Glu Lys Glu Arg Phe Arg Lys Ala Pro Pro Asn Tyr 
    370                 375                 380                 


Ala Met Lys Lys Thr Gln Leu Leu Lys Glu Lys Ala Met Ala Glu Asp 
385                 390                 395                 400 


Leu Gly Asp Gln Asp Lys Ala Lys Gln Ile Gln Asp Gln Leu Asn Glu 
                405                 410                 415     


Leu Glu Glu Arg Ala Glu Ala Leu Asp Arg Gln Arg Thr Lys Asn Ile 
            420                 425                 430         


Ser Ala Ile Ser Tyr Ile Asn Gln Arg Asn Arg Glu Trp Asn Ile Val 
        435                 440                 445             


Glu Ser Glu Lys Ala Leu Val Ala Glu Ser His Asn Met Lys Asn Gln 
    450                 455                 460                 


Gln Met Asp Pro Phe Thr Arg Arg Gln Cys Lys Pro Thr Ile Val Ser 
465                 470                 475                 480 


Asn Ser Arg Asp Pro Ala Val Gln Ala Ala Ile Leu Ala Gln Leu Asn 
                485                 490                 495     


Ala Lys Tyr Gly Ser Gly Val Leu Pro Asp Ala Pro Lys Glu Met Ser 
            500                 505                 510         


Lys Gly Gln Gly Lys Asp Lys Asp Leu Asn Ser Lys Ser Ala Ser Asp 
        515                 520                 525             


Leu Ser Glu Asp Leu Phe Lys Val His Asp Phe Asp Val Lys Ile Asp 
    530                 535                 540                 


Leu Gln Val Pro Ser Ser Glu Ser Lys Ala Leu Ala Ile Thr Ser Lys 
545                 550                 555                 560 


Ala Pro Pro Ala Lys Asp Gly Ala Pro Arg Arg Ser Leu Asn Leu Glu 
                565                 570                 575     


Asp Tyr Lys Lys Arg Arg Gly Leu Ile 
            580                 585 


<210>  26
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Asp Ser Gly Asp Ala Gly Ser Ser Gly Pro Trp Trp Lys Ser 
1               5                   10                  15      


Leu Thr Asn Ser Arg Lys Lys Ser Lys Glu Ala Ala Val Gly Val Pro 
            20                  25                  30          


Pro Pro Ala Gln Pro Ala Pro Gly Glu Pro Thr Pro Pro Ala Pro Pro 
        35                  40                  45              


Ser Pro Asp Trp Thr Ser Ser Ser Arg Glu Asn Gln His Pro Asn Leu 
    50                  55                  60                  


Leu Gly Gly Ala Gly Glu Pro Pro Lys Pro Asp Lys Leu Tyr Gly Asp 
65                  70                  75                  80  


Lys Ser Gly Ser Ser Arg Arg Asn Leu Lys Ile Ser Arg Ser Gly Arg 
                85                  90                  95      


Phe Lys Glu Lys Arg Lys Val Arg Ala Thr Leu Leu Pro Glu Ala Gly 
            100                 105                 110         


Arg Ser Pro Glu Glu Ala Gly Phe Pro Gly Asp Pro His Glu Asp Lys 
        115                 120                 125             


Gln 
    


<210>  27
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asp Val Thr Ile Gln His Pro Trp Phe Lys Arg Thr Leu Gly Pro 
1               5                   10                  15      


Phe Tyr Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu Gly Leu Phe 
            20                  25                  30          


Glu Tyr Asp Leu Leu Pro Phe Leu Ser Ser Thr Ile Ser Pro Tyr Tyr 
        35                  40                  45              


Arg Gln Ser Leu Phe Arg Thr Val Leu Asp Ser Gly Ile Ser Glu Val 
    50                  55                  60                  


Arg Ser Asp Arg Asp Lys Phe Val Ile Phe Leu Asp Val Lys His Phe 
65                  70                  75                  80  


Ser Pro Glu Asp Leu Thr Val Lys Val Gln Asp Asp Phe Val Glu Ile 
                85                  90                  95      


His Gly Lys His Asn Glu Arg Gln Asp Asp His Gly Tyr Ile Ser Arg 
            100                 105                 110         


Glu Phe His Arg Arg Tyr Arg Leu Pro Ser Asn Val Asp Gln Ser Ala 
        115                 120                 125             


Leu Ser Cys Ser Leu Ser Ala Asp Gly Met Leu Thr Phe Cys Gly Pro 
    130                 135                 140                 


Lys Ile Gln Thr Gly Leu Asp Ala Thr His Ala Glu Arg Ala Ile Pro 
145                 150                 155                 160 


Val Ser Arg Glu Glu Lys Pro Thr Ser Ala Pro Ser Ser 
                165                 170             


<210>  28
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Gln Lys Thr Ser Met Ser Arg Gly Pro Tyr Pro Pro Ser Gln 
1               5                   10                  15      


Glu Ile Pro Met Glu Val Phe Asp Pro Ser Pro Gln Gly Lys Tyr Ser 
            20                  25                  30          


Lys Arg Lys Gly Arg Phe Lys Arg Ser Asp Gly Ser Thr Ser Ser Asp 
        35                  40                  45              


Thr Thr Ser Asn Ser Phe Val Arg Gln Gly Ser Ala Glu Ser Tyr Thr 
    50                  55                  60                  


Ser Arg Pro Ser Asp Ser Asp Val Ser Leu Glu Glu Asp Arg Glu Ala 
65                  70                  75                  80  


Leu Arg Lys Glu Ala Glu Arg Gln Ala Leu Ala Gln Leu Glu Lys Ala 
                85                  90                  95      


Lys Thr Lys Pro Val Ala Phe Ala Val Arg Thr Asn Val Gly Tyr Asn 
            100                 105                 110         


Pro Ser Pro Gly Asp Glu Val Pro Val Gln Gly Val Ala Ile Thr Phe 
        115                 120                 125             


Glu Pro Lys Asp Phe Leu His Ile Lys Glu Lys Tyr Asn Asn Asp Trp 
    130                 135                 140                 


Trp Ile Gly Arg Leu Val Lys Glu Gly Cys Glu Val Gly Phe Ile Pro 
145                 150                 155                 160 


Ser Pro Val Lys Leu Asp Ser Leu Arg Leu Leu Gln Glu Gln Lys Leu 
                165                 170                 175     


Arg Gln Asn Arg Leu Gly Ser Ser Lys Ser Gly Asp Asn Ser Ser Ser 
            180                 185                 190         


Ser Leu Gly Asp Val Val Thr Gly Thr Arg Arg Pro Thr Pro Pro Ala 
        195                 200                 205             


Ser Ala Lys Gln Lys Gln Lys Ser Thr Glu His Val Pro Pro Tyr Asp 
    210                 215                 220                 


Val Val Pro Ser Met Arg Pro Ile Ile Leu Val Gly Pro Ser Leu Lys 
225                 230                 235                 240 


Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu 
                245                 250                 255     


Lys His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp 
            260                 265                 270         


Ile Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ile 
        275                 280                 285             


Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser 
    290                 295                 300                 


Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Ala 
305                 310                 315                 320 


Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser 
                325                 330                 335     


Leu Ala Pro Ile Ile Val Tyr Ile Lys Ile Thr Ser Pro Lys Val Leu 
            340                 345                 350         


Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser Gln Ser Lys His Leu Asn 
        355                 360                 365             


Val Gln Ile Ala Ala Ser Glu Lys Leu Ala Gln Cys Pro Pro Glu Met 
    370                 375                 380                 


Phe Asp Ile Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His 
385                 390                 395                 400 


Leu Ala Glu Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser 
                405                 410                 415     


Ser Thr Pro Pro Asn Pro Leu Leu Asn Arg Thr Met Ala Thr Ala Ala 
            420                 425                 430         


Leu Ala Ala Ser Pro Ala Pro Val Ser Asn Leu Gln Gly Pro Tyr Leu 
        435                 440                 445             


Ala Ser Gly Asp Gln Pro Leu Glu Arg Ala Thr Gly Glu His Ala Ser 
    450                 455                 460                 


Met His Glu Tyr Pro Gly Glu Leu Gly Gln Pro Pro Gly Leu Tyr Pro 
465                 470                 475                 480 


Ser Ser His Pro Pro Gly Arg Ala Gly Thr Leu Arg Ala Leu Ser Arg 
                485                 490                 495     


Gln Asp Thr Phe Asp Ala Asp Thr Pro Gly Ser Arg Asn Ser Ala Tyr 
            500                 505                 510         


Thr Glu Leu Gly Asp Ser Cys Val Asp Met Glu Thr Asp Pro Ser Glu 
        515                 520                 525             


Gly Pro Gly Leu Gly Asp Pro Ala Gly Gly Gly Thr Pro Pro Ala Arg 
    530                 535                 540                 


Gln Gly Ser Trp Glu Asp Glu Glu Glu Asp Tyr Glu Glu Glu Leu Thr 
545                 550                 555                 560 


Asp Asn Arg Asn Arg Gly Arg Asn Lys Ala Arg Tyr Cys Ala Glu Gly 
                565                 570                 575     


Gly Gly Pro Val Leu Gly Arg Asn Lys Asn Glu Leu Glu Gly Trp Gly 
            580                 585                 590         


Arg Gly Val Tyr Ile Arg 
        595             


<210>  29
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Asp Phe Val Met Lys Gln Ala Leu Gly Gly Ala Thr Lys Asp Met 
1               5                   10                  15      


Gly Lys Met Leu Gly Gly Glu Glu Glu Lys Asp Pro Asp Ala Gln Lys 
            20                  25                  30          


Lys Glu Glu Glu Arg Gln Glu Ala Leu Arg Gln Gln Glu Glu Glu Arg 
        35                  40                  45              


Lys Ala Lys His Ala Arg Met Glu Ala Glu Arg Glu Lys Val Arg Gln 
    50                  55                  60                  


Gln Ile Arg Asp Lys Tyr Gly Leu Lys Lys Lys Glu Glu Lys Glu Ala 
65                  70                  75                  80  


Glu Glu Lys Ala Ala Leu Glu Gln Pro Cys Glu Gly Ser Leu Thr Arg 
                85                  90                  95      


Pro Lys Lys Ala Ile Pro Ala Gly Cys Gly Asp Glu Glu Glu Glu Glu 
            100                 105                 110         


Glu Glu Ser Ile Leu Asp Thr Val Leu Lys Tyr Leu Pro Gly Pro Leu 
        115                 120                 125             


Gln Asp Met Phe Lys Lys 
    130                 


<210>  30
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Trp 
1               5                   10                  15      


Pro Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210>  31
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Lys Cys Pro Lys Cys Asp Lys Thr Val Tyr Phe Ala Glu Lys Val 
1               5                   10                  15      


Ser Ser Leu Gly Lys Asp Trp His Lys Phe Cys Leu Lys Cys Glu Arg 
            20                  25                  30          


Cys Ser Lys Thr Leu Thr Pro Gly Gly His Ala Glu His Asp Gly Lys 
        35                  40                  45              


Pro Phe Cys His Lys Pro Cys Tyr Ala Thr Leu Phe Gly Pro Lys Gly 
    50                  55                  60                  


Val Asn Ile Gly Gly Ala Gly Ser Tyr Ile Tyr Glu Lys Pro Leu Ala 
65                  70                  75                  80  


Glu Gly Pro Gln Val Thr Gly Pro Ile Glu Val Pro Ala Ala Arg Ala 
                85                  90                  95      


Glu Glu Arg Lys Ala Ser Gly Pro Pro Lys Gly Pro Ser Arg Ala Ser 
            100                 105                 110         


Ser Val Thr Thr Phe Thr Gly Glu Pro Asn Thr Cys Pro Arg Cys Ser 
        115                 120                 125             


Lys Lys Val Tyr Phe Ala Glu Lys Val Thr Ser Leu Gly Lys Asp Trp 
    130                 135                 140                 


His Arg Pro Cys Leu Arg Cys Glu Arg Cys Gly Lys Thr Leu Thr Pro 
145                 150                 155                 160 


Gly Gly His Ala Glu His Asp Gly Gln Pro Tyr Cys His Lys Pro Cys 
                165                 170                 175     


Tyr Gly Ile Leu Phe Gly Pro Lys Gly Val Asn Thr Gly Ala Val Gly 
            180                 185                 190         


Ser Tyr Ile Tyr Asp Arg Asp Pro Glu Gly Lys Val Gln Pro 
        195                 200                 205     


<210>  32
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Glu Thr Asp Pro Lys Thr Val Gln Asp Leu Thr Ser Val Val 
1               5                   10                  15      


Gln Thr Leu Leu Gln Gln Met Gln Asp Lys Phe Gln Thr Met Ser Asp 
            20                  25                  30          


Gln Ile Ile Gly Arg Ile Asp Asp Met Ser Ser Arg Ile Asp Asp Leu 
        35                  40                  45              


Glu Lys Asn Ile Ala Asp Leu Met Thr Gln Ala Gly Val Glu Glu Leu 
    50                  55                  60                  


Glu Ser Glu Asn Lys Ile Pro Ala Thr Gln Lys Ser 
65                  70                  75      


<210>  33
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Asp Val Phe Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val 
1               5                   10                  15      


Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val 
    130                 135                 140                 


Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn 
    210                 215                 220                 


Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro 
305                 310                 315                 320 


Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu 
                325                 330                 335     


Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys 
            340                 345                 350         


Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys 
        355                 360                 365             


Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr 
    370                 375                 380                 


Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu 
385                 390                 395                 400 


Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val 
                405                 410                 415     


Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val 
            420                 425                 430         


Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser 
        435                 440                 445             


Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu 
    450                 455                 460                 


Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala 
465                 470                 475                 480 


Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg 
                485                 490                 495     


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr 
            500                 505                 510         


Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu 
        515                 520                 525             


Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp 
    530                 535                 540                 


Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser 
545                 550                 555                 560 


Leu Ser Lys Glu Ala Val Ser Ile Cys Lys Gly Leu Met Thr Lys His 
                565                 570                 575     


Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg 
            580                 585                 590         


Glu His Ala Phe Phe Arg Arg Ile Asp Trp Glu Lys Leu Glu Asn Arg 
        595                 600                 605             


Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Cys Gly Lys Gly Ala Glu 
    610                 615                 620                 


Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro 
625                 630                 635                 640 


Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe 
                645                 650                 655     


Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val 
            660                 665                 670         


<210>  34
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Pro Thr Gln Arg Asp Ser Ser Thr Met Ser His Thr Val Ala Gly 
1               5                   10                  15      


Gly Gly Ser Gly Asp His Ser His Gln Val Arg Val Lys Ala Tyr Tyr 
            20                  25                  30          


Arg Gly Asp Ile Met Ile Thr His Phe Glu Pro Ser Ile Ser Phe Glu 
        35                  40                  45              


Gly Leu Cys Asn Glu Val Arg Asp Met Cys Ser Phe Asp Asn Glu Gln 
    50                  55                  60                  


Leu Phe Thr Met Lys Trp Ile Asp Glu Glu Gly Asp Pro Cys Thr Val 
65                  70                  75                  80  


Ser Ser Gln Leu Glu Leu Glu Glu Ala Phe Arg Leu Tyr Glu Leu Asn 
                85                  90                  95      


Lys Asp Ser Glu Leu Leu Ile His Val Phe Pro Cys Val Pro Glu Arg 
            100                 105                 110         


Pro Gly Met Pro Cys Pro Gly Glu Asp Lys Ser Ile Tyr Arg Arg Gly 
        115                 120                 125             


Ala Arg Arg Trp Arg Lys Leu Tyr Cys Ala Asn Gly His Thr Phe Gln 
    130                 135                 140                 


Ala Lys Arg Phe Asn Arg Arg Ala His Cys Ala Ile Cys Thr Asp Arg 
145                 150                 155                 160 


Ile Trp Gly Leu Gly Arg Gln Gly Tyr Lys Cys Ile Asn Cys Lys Leu 
                165                 170                 175     


Leu Val His Lys Lys Cys His Lys Leu Val Thr Ile Glu Cys Gly Arg 
            180                 185                 190         


His Ser Leu Pro Gln Glu Pro Val Met Pro Met Asp Gln Ser Ser Met 
        195                 200                 205             


His Ser Asp His Ala Gln Thr Val Ile Pro Tyr Asn Pro Ser Ser His 
    210                 215                 220                 


Glu Ser Leu Asp Gln Val Gly Glu Glu Lys Glu Ala Met Asn Thr Arg 
225                 230                 235                 240 


Glu Ser Gly Lys Ala Ser Ser Ser Leu Gly Leu Gln Asp Phe Asp Leu 
                245                 250                 255     


Leu Arg Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg 
            260                 265                 270         


Leu Lys Lys Thr Asp Arg Ile Tyr Ala Met Lys Val Val Lys Lys Glu 
        275                 280                 285             


Leu Val Asn Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His 
    290                 295                 300                 


Val Phe Glu Gln Ala Ser Asn His Pro Phe Leu Val Gly Leu His Ser 
305                 310                 315                 320 


Cys Phe Gln Thr Glu Ser Arg Leu Phe Phe Val Ile Glu Tyr Val Asn 
                325                 330                 335     


Gly Gly Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu 
            340                 345                 350         


Glu His Ala Arg Phe Tyr Ser Ala Glu Ile Ser Leu Ala Leu Asn Tyr 
        355                 360                 365             


Leu His Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val 
    370                 375                 380                 


Leu Leu Asp Ser Glu Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys 
385                 390                 395                 400 


Lys Glu Gly Leu Arg Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr 
                405                 410                 415     


Pro Asn Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Asp Tyr Gly Phe 
            420                 425                 430         


Ser Val Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala 
        435                 440                 445             


Gly Arg Ser Pro Phe Asp Ile Val Gly Ser Ser Asp Asn Pro Asp Gln 
    450                 455                 460                 


Asn Thr Glu Asp Tyr Leu Phe Gln Val Ile Leu Glu Lys Gln Ile Arg 
465                 470                 475                 480 


Ile Pro Arg Ser Leu Ser Val Lys Ala Ala Ser Val Leu Lys Ser Phe 
                485                 490                 495     


Leu Asn Lys Asp Pro Lys Glu Arg Leu Gly Cys His Pro Gln Thr Gly 
            500                 505                 510         


Phe Ala Asp Ile Gln Gly His Pro Phe Phe Arg Asn Val Asp Trp Asp 
        515                 520                 525             


Met Met Glu Gln Lys Gln Val Val Pro Pro Phe Lys Pro Asn Ile Ser 
    530                 535                 540                 


Gly Glu Phe Gly Leu Asp Asn Phe Asp Ser Gln Phe Thr Asn Glu Pro 
545                 550                 555                 560 


Val Gln Leu Thr Pro Asp Asp Asp Asp Ile Val Arg Lys Ile Asp Gln 
                565                 570                 575     


Ser Glu Phe Glu Gly Phe Glu Tyr Ile Asn Pro Leu Leu Met Ser Ala 
            580                 585                 590         


Glu Glu Cys Val 
        595     


<210>  35
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Ser Arg Thr Gly Pro Lys Met Glu Gly Ser Gly Gly Arg Val 
1               5                   10                  15      


Arg Leu Lys Ala His Tyr Gly Gly Asp Ile Phe Ile Thr Ser Val Asp 
            20                  25                  30          


Ala Ala Thr Thr Phe Glu Glu Leu Cys Glu Glu Val Arg Asp Met Cys 
        35                  40                  45              


Arg Leu His Gln Gln His Pro Leu Thr Leu Lys Trp Val Asp Ser Glu 
    50                  55                  60                  


Gly Asp Pro Cys Thr Val Ser Ser Gln Met Glu Leu Glu Glu Ala Phe 
65                  70                  75                  80  


Arg Leu Ala Arg Gln Cys Arg Asp Glu Gly Leu Ile Ile His Val Phe 
                85                  90                  95      


Pro Ser Thr Pro Glu Gln Pro Gly Leu Pro Cys Pro Gly Glu Asp Lys 
            100                 105                 110         


Ser Ile Tyr Arg Arg Gly Ala Arg Arg Trp Arg Lys Leu Tyr Arg Ala 
        115                 120                 125             


Asn Gly His Leu Phe Gln Ala Lys Arg Phe Asn Arg Arg Ala Tyr Cys 
    130                 135                 140                 


Gly Gln Cys Ser Glu Arg Ile Trp Gly Leu Ala Arg Gln Gly Tyr Arg 
145                 150                 155                 160 


Cys Ile Asn Cys Lys Leu Leu Val His Lys Arg Cys His Gly Leu Val 
                165                 170                 175     


Pro Leu Thr Cys Arg Lys His Met Asp Ser Val Met Pro Ser Gln Glu 
            180                 185                 190         


Pro Pro Val Asp Asp Lys Asn Glu Asp Ala Asp Leu Pro Ser Glu Glu 
        195                 200                 205             


Thr Asp Gly Ile Ala Tyr Ile Ser Ser Ser Arg Lys His Asp Ser Ile 
    210                 215                 220                 


Lys Asp Asp Ser Glu Asp Leu Lys Pro Val Ile Asp Gly Met Asp Gly 
225                 230                 235                 240 


Ile Lys Ile Ser Gln Gly Leu Gly Leu Gln Asp Phe Asp Leu Ile Arg 
                245                 250                 255     


Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg Leu Lys 
            260                 265                 270         


Lys Asn Asp Gln Ile Tyr Ala Met Lys Val Val Lys Lys Glu Leu Val 
        275                 280                 285             


His Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His Val Phe 
    290                 295                 300                 


Glu Gln Ala Ser Ser Asn Pro Phe Leu Val Gly Leu His Ser Cys Phe 
305                 310                 315                 320 


Gln Thr Thr Ser Arg Leu Phe Leu Val Ile Glu Tyr Val Asn Gly Gly 
                325                 330                 335     


Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu Glu His 
            340                 345                 350         


Ala Arg Phe Tyr Ala Ala Glu Ile Cys Ile Ala Leu Asn Phe Leu His 
        355                 360                 365             


Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu Leu 
    370                 375                 380                 


Asp Ala Asp Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys Lys Glu 
385                 390                 395                 400 


Gly Leu Gly Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr Pro Asn 
                405                 410                 415     


Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Glu Tyr Gly Phe Ser Val 
            420                 425                 430         


Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala Gly Arg 
        435                 440                 445             


Ser Pro Phe Asp Ile Ile Thr Asp Asn Pro Asp Met Asn Thr Glu Asp 
    450                 455                 460                 


Tyr Leu Phe Gln Val Ile Leu Glu Lys Pro Ile Arg Ile Pro Arg Phe 
465                 470                 475                 480 


Leu Ser Val Lys Ala Ser His Val Leu Lys Gly Phe Leu Asn Lys Asp 
                485                 490                 495     


Pro Lys Glu Arg Leu Gly Cys Arg Pro Gln Thr Gly Phe Ser Asp Ile 
            500                 505                 510         


Lys Ser His Ala Phe Phe Arg Ser Ile Asp Trp Asp Leu Leu Glu Lys 
        515                 520                 525             


Lys Gln Ala Leu Pro Pro Phe Gln Pro Gln Ile Thr Asp Asp Tyr Gly 
    530                 535                 540                 


Leu Asp Asn Phe Asp Thr Gln Phe Thr Ser Glu Pro Val Gln Leu Thr 
545                 550                 555                 560 


Pro Asp Asp Glu Asp Ala Ile Lys Arg Ile Asp Gln Ser Glu Phe Glu 
                565                 570                 575     


Gly Phe Glu Tyr Ile Asn Pro Leu Leu Leu Ser Thr Glu Glu Ser Val 
            580                 585                 590         


<210>  36
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Ala Pro Val Val Ala Pro Pro Gly Val Val Val Ser Arg Ala 
1               5                   10                  15      


Asn Lys Arg Ser Gly Ala Gly Pro Gly Gly Ser Gly Gly Gly Gly Ala 
            20                  25                  30          


Arg Gly Ala Glu Glu Glu Pro Pro Pro Pro Leu Gln Ala Val Leu Val 
        35                  40                  45              


Ala Asp Ser Phe Asp Arg Arg Phe Phe Pro Ile Ser Lys Asp Gln Pro 
    50                  55                  60                  


Arg Val Leu Leu Pro Leu Ala Asn Val Ala Leu Ile Asp Tyr Thr Leu 
65                  70                  75                  80  


Glu Phe Leu Thr Ala Thr Gly Val Gln Glu Thr Phe Val Phe Cys Cys 
                85                  90                  95      


Trp Lys Ala Ala Gln Ile Lys Glu His Leu Leu Lys Ser Lys Trp Cys 
            100                 105                 110         


Arg Pro Thr Ser Leu Asn Val Val Arg Ile Ile Thr Ser Glu Leu Tyr 
        115                 120                 125             


Arg Ser Leu Gly Asp Val Leu Arg Asp Val Asp Ala Lys Ala Leu Val 
    130                 135                 140                 


Arg Ser Asp Phe Leu Leu Val Tyr Gly Asp Val Ile Ser Asn Ile Asn 
145                 150                 155                 160 


Ile Thr Arg Ala Leu Glu Glu His Arg Leu Arg Arg Lys Leu Glu Lys 
                165                 170                 175     


Asn Val Ser Val Met Thr Met Ile Phe Lys Glu Ser Ser Pro Ser His 
            180                 185                 190         


Pro Thr Arg Cys His Glu Asp Asn Val Val Val Ala Val Asp Ser Thr 
        195                 200                 205             


Thr Asn Arg Val Leu His Phe Gln Lys Thr Gln Gly Leu Arg Arg Phe 
    210                 215                 220                 


Ala Phe Pro Leu Ser Leu Phe Gln Gly Ser Ser Asp Gly Val Glu Val 
225                 230                 235                 240 


Arg Tyr Asp Leu Leu Asp Cys His Ile Ser Ile Cys Ser Pro Gln Val 
                245                 250                 255     


Ala Gln Leu Phe Thr Asp Asn Phe Asp Tyr Gln Thr Arg Asp Asp Phe 
            260                 265                 270         


Val Arg Gly Leu Leu Val Asn Glu Glu Ile Leu Gly Asn Gln Ile His 
        275                 280                 285             


Met His Val Thr Ala Lys Glu Tyr Gly Ala Arg Val Ser Asn Leu His 
    290                 295                 300                 


Met Tyr Ser Ala Val Cys Ala Asp Val Ile Arg Arg Trp Val Tyr Pro 
305                 310                 315                 320 


Leu Thr Pro Glu Ala Asn Phe Thr Asp Ser Thr Thr Gln Ser Cys Thr 
                325                 330                 335     


His Ser Arg His Asn Ile Tyr Arg Gly Pro Glu Val Ser Leu Gly His 
            340                 345                 350         


Gly Ser Ile Leu Glu Glu Asn Val Leu Leu Gly Ser Gly Thr Val Ile 
        355                 360                 365             


Gly Ser Asn Cys Phe Ile Thr Asn Ser Val Ile Gly Pro Gly Cys His 
    370                 375                 380                 


Ile Gly Asp Asn Val Val Leu Asp Gln Thr Tyr Leu Trp Gln Gly Val 
385                 390                 395                 400 


Arg Val Ala Ala Gly Ala Gln Ile His Gln Ser Leu Leu Cys Asp Asn 
                405                 410                 415     


Ala Glu Val Lys Glu Arg Val Thr Leu Lys Pro Arg Ser Val Leu Thr 
            420                 425                 430         


Ser Gln Val Val Val Gly Pro Asn Ile Thr Leu Pro Glu Gly Ser Val 
        435                 440                 445             


Ile Ser Leu His Pro Pro Asp Ala Glu Glu Asp Glu Asp Asp Gly Glu 
    450                 455                 460                 


Phe Ser Asp Asp Ser Gly Ala Asp Gln Glu Lys Asp Lys Val Lys Met 
465                 470                 475                 480 


Lys Gly Tyr Asn Pro Ala Glu Val Gly Ala Ala Gly Lys Gly Tyr Leu 
                485                 490                 495     


Trp Lys Ala Ala Gly Met Asn Met Glu Glu Glu Glu Glu Leu Gln Gln 
            500                 505                 510         


Asn Leu Trp Gly Leu Lys Ile Asn Met Glu Glu Glu Ser Glu Ser Glu 
        515                 520                 525             


Ser Glu Gln Ser Met Asp Ser Glu Glu Pro Asp Ser Arg Gly Gly Ser 
    530                 535                 540                 


Pro Gln Met Asp Asp Ile Lys Val Phe Gln Asn Glu Val Leu Gly Thr 
545                 550                 555                 560 


Leu Gln Arg Gly Lys Glu Glu Asn Ile Ser Cys Asp Asn Leu Val Leu 
                565                 570                 575     


Glu Ile Asn Ser Leu Lys Tyr Ala Tyr Asn Val Ser Leu Lys Glu Val 
            580                 585                 590         


Met Gln Val Leu Ser His Val Val Leu Glu Phe Pro Leu Gln Gln Met 
        595                 600                 605             


Asp Ser Pro Leu Asp Ser Ser Arg Tyr Cys Ala Leu Leu Leu Pro Leu 
    610                 615                 620                 


Leu Lys Ala Trp Ser Pro Val Phe Arg Asn Tyr Ile Lys Arg Ala Ala 
625                 630                 635                 640 


Asp His Leu Glu Ala Leu Ala Ala Ile Glu Asp Phe Phe Leu Glu His 
                645                 650                 655     


Glu Ala Leu Gly Ile Ser Met Ala Lys Val Leu Met Ala Phe Tyr Gln 
            660                 665                 670         


Leu Glu Ile Leu Ala Glu Glu Thr Ile Leu Ser Trp Phe Ser Gln Arg 
        675                 680                 685             


Asp Thr Thr Asp Lys Gly Gln Gln Leu Arg Lys Asn Gln Gln Leu Gln 
    690                 695                 700                 


Arg Phe Ile Gln Trp Leu Lys Glu Ala Glu Glu Glu Ser Ser Glu Asp 
705                 710                 715                 720 


Asp 
    


<210>  37
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Pro Lys Val Lys Arg Ser Arg Lys Ala Pro Pro Asp Gly Trp Glu 
1               5                   10                  15      


Leu Ile Glu Pro Thr Leu Asp Glu Leu Asp Gln Lys Met Arg Glu Ala 
            20                  25                  30          


Glu Thr Glu Pro His Glu Gly Lys Arg Lys Val Glu Ser Leu Trp Pro 
        35                  40                  45              


Ile Phe Arg Ile His His Gln Lys Thr Arg Tyr Ile Phe Asp Leu Phe 
    50                  55                  60                  


Tyr Lys Arg Lys Ala Ile Ser Arg Glu Leu Tyr Glu Tyr Cys Ile Lys 
65                  70                  75                  80  


Glu Gly Tyr Ala Asp Lys Asn Leu Ile Ala Lys Trp Lys Lys Gln Gly 
                85                  90                  95      


Tyr Glu Asn Leu Cys Cys Leu Arg Cys Ile Gln Thr Arg Asp Thr Asn 
            100                 105                 110         


Phe Gly Thr Asn Cys Ile Cys Arg Val Pro Lys Ser Lys Leu Glu Val 
        115                 120                 125             


Gly Arg Ile Ile Glu Cys Thr His Cys Gly Cys Arg Gly Cys Ser 
    130                 135                 140             


<210>  38
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met 
1               5                   10                  15      


Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu 
            20                  25                  30          


Phe Gly Pro Val Asp His Glu Glu Leu Thr Arg Asp Leu Glu Lys His 
        35                  40                  45              


Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe 
    50                  55                  60                  


Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu 
65                  70                  75                  80  


Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys 
                85                  90                  95      


Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser 
            100                 105                 110         


Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Thr 
        115                 120                 125             


His Leu Val Asp Pro Lys Thr Asp Pro Ser Asp Ser Gln Thr Gly Leu 
    130                 135                 140                 


Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Thr Asp Asp Ser 
145                 150                 155                 160 


Ser Thr Gln Asn Lys Arg Ala Asn Arg Thr Glu Glu Asn Val Ser Asp 
                165                 170                 175     


Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly 
            180                 185                 190         


Leu Arg Arg Arg Gln Thr 
        195             


<210>  39
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Ser Pro Pro Glu Gly Lys Leu Glu Thr Lys Ala Gly His Pro 
1               5                   10                  15      


Pro Ala Val Lys Ala Gly Gly Met Arg Ile Val Gln Lys His Pro His 
            20                  25                  30          


Thr Gly Asp Thr Lys Glu Glu Lys Asp Lys Asp Asp Gln Glu Trp Glu 
        35                  40                  45              


Ser Pro Ser Pro Pro Lys Pro Thr Val Phe Ile Ser Gly Val Ile Ala 
    50                  55                  60                  


Arg Gly Asp Lys Asp Phe Pro Pro Ala Ala Ala Gln Val Ala His Gln 
65                  70                  75                  80  


Lys Pro His Ala Ser Met Asp Lys His Pro Ser Pro Arg Thr Gln His 
                85                  90                  95      


Ile Gln Gln Pro Arg Lys 
            100         


<210>  40
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Val Val Thr Thr Asp Ala Glu Ser Glu Thr Gly Ile Pro Lys 
1               5                   10                  15      


Ser Leu Ser Asn Glu Pro Pro Ser Glu Thr Met Glu Glu Ile Glu His 
            20                  25                  30          


Thr Cys Pro Gln Pro Arg Leu Thr Leu Thr Ala Pro Ala Pro Phe Ala 
        35                  40                  45              


Asp Glu Thr Asn Cys Gln Cys Gln Ala Pro His Glu Lys Leu Thr Ile 
    50                  55                  60                  


Ala Gln Ala Arg Leu Gly Thr Pro Ala Asp Arg Pro Val Arg Val Tyr 
65                  70                  75                  80  


Ala Asp Gly Ile Phe Asp Leu Phe His Ser Gly His Ala Arg Ala Leu 
                85                  90                  95      


Met Gln Ala Lys Thr Leu Phe Pro Asn Ser Tyr Leu Leu Val Gly Val 
            100                 105                 110         


Cys Ser Asp Asp Leu Thr His Lys Phe Lys Gly Phe Thr Val Met Asn 
        115                 120                 125             


Glu Ala Glu Arg Tyr Glu Ala Leu Arg His Cys Arg Tyr Val Asp Glu 
    130                 135                 140                 


Val Ile Arg Asp Ala Pro Trp Thr Leu Thr Pro Glu Phe Leu Glu Lys 
145                 150                 155                 160 


His Lys Ile Asp Phe Val Ala His Asp Asp Ile Pro Tyr Ser Ser Ala 
                165                 170                 175     


Gly Ser Asp Asp Val Tyr Lys His Ile Lys Glu Ala Gly Met Phe Val 
            180                 185                 190         


Pro Thr Gln Arg Thr Glu Gly Ile Ser Thr Ser Asp Ile Ile Thr Arg 
        195                 200                 205             


Ile Val Arg Asp Tyr Asp Val Tyr Ala Arg Arg Asn Leu Gln Arg Gly 
    210                 215                 220                 


Tyr Thr Ala Lys Glu Leu Asn Val Ser Phe Ile Asn Glu Lys Arg Tyr 
225                 230                 235                 240 


Arg Phe Gln Asn Gln Val Asp Lys Met Lys Glu Lys Val Lys Asn Val 
                245                 250                 255     


Glu Glu Arg Ser Lys Glu Phe Val Asn Arg Val Glu Glu Lys Ser His 
            260                 265                 270         


Asp Leu Ile Gln Lys Trp Glu Glu Lys Ser Arg Glu Phe Ile Gly Asn 
        275                 280                 285             


Phe Leu Glu Leu Phe Gly Pro Asp Gly Ala Trp Lys Gln Met Phe Gln 
    290                 295                 300                 


Glu Arg Ser Ser Arg Met Leu Gln Ala Leu Ser Pro Lys Gln Ser Pro 
305                 310                 315                 320 


Val Ser Ser Pro Thr Arg Ser Arg Ser Pro Ser Arg Ser Pro Ser Pro 
                325                 330                 335     


Thr Phe Ser Trp Leu Pro Leu Lys Thr Ser Pro Pro Ser Ser Pro Lys 
            340                 345                 350         


Ala Ala Ser Ala Ser Ile Ser Ser Met Ser Glu Gly Asp Glu Asp Glu 
        355                 360                 365             


Lys 
    


<210>  41
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Pro Lys Arg Lys Val Ser Ser Ala Glu Gly Ala Ala Lys Glu Glu 
1               5                   10                  15      


Pro Lys Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro Pro Ala Lys Val 
            20                  25                  30          


Glu Ala Lys Pro Lys Lys Ala Ala Ala Lys Asp Lys Ser Ser Asp Lys 
        35                  40                  45              


Lys Val Gln Thr Lys Gly Lys Arg Gly Ala Lys Gly Lys Gln Ala Glu 
    50                  55                  60                  


Val Ala Asn Gln Glu Thr Lys Glu Asp Leu Pro Ala Glu Asn Gly Glu 
65                  70                  75                  80  


Thr Lys Thr Glu Glu Ser Pro Ala Ser Asp Glu Ala Gly Glu Lys Glu 
                85                  90                  95      


Ala Lys Ser Asp 
            100 


<210>  42
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Ala Ala Val Thr Ala Gly Lys Leu Ala Arg Ala Pro Ala Asp 
1               5                   10                  15      


Pro Gly Lys Ala Gly Val Pro Gly Val Ala Ala Pro Gly Ala Pro Ala 
            20                  25                  30          


Ala Ala Pro Pro Ala Lys Glu Ile Pro Glu Val Leu Val Asp Pro Arg 
        35                  40                  45              


Ser Arg Arg Arg Tyr Val Arg Gly Arg Phe Leu Gly Lys Gly Gly Phe 
    50                  55                  60                  


Ala Lys Cys Phe Glu Ile Ser Asp Ala Asp Thr Lys Glu Val Phe Ala 
65                  70                  75                  80  


Gly Lys Ile Val Pro Lys Ser Leu Leu Leu Lys Pro His Gln Arg Glu 
                85                  90                  95      


Lys Met Ser Met Glu Ile Ser Ile His Arg Ser Leu Ala His Gln His 
            100                 105                 110         


Val Val Gly Phe His Gly Phe Phe Glu Asp Asn Asp Phe Val Phe Val 
        115                 120                 125             


Val Leu Glu Leu Cys Arg Arg Arg Ser Leu Leu Glu Leu His Lys Arg 
    130                 135                 140                 


Arg Lys Ala Leu Thr Glu Pro Glu Ala Arg Tyr Tyr Leu Arg Gln Ile 
145                 150                 155                 160 


Val Leu Gly Cys Gln Tyr Leu His Arg Asn Arg Val Ile His Arg Asp 
                165                 170                 175     


Leu Lys Leu Gly Asn Leu Phe Leu Asn Glu Asp Leu Glu Val Lys Ile 
            180                 185                 190         


Gly Asp Phe Gly Leu Ala Thr Lys Val Glu Tyr Asp Gly Glu Arg Lys 
        195                 200                 205             


Lys Thr Leu Cys Gly Thr Pro Asn Tyr Ile Ala Pro Glu Val Leu Ser 
    210                 215                 220                 


Lys Lys Gly His Ser Phe Glu Val Asp Val Trp Ser Ile Gly Cys Ile 
225                 230                 235                 240 


Met Tyr Thr Leu Leu Val Gly Lys Pro Pro Phe Glu Thr Ser Cys Leu 
                245                 250                 255     


Lys Glu Thr Tyr Leu Arg Ile Lys Lys Asn Glu Tyr Ser Ile Pro Lys 
            260                 265                 270         


His Ile Asn Pro Val Ala Ala Ser Leu Ile Gln Lys Met Leu Gln Thr 
        275                 280                 285             


Asp Pro Thr Ala Arg Pro Thr Ile Asn Glu Leu Leu Asn Asp Glu Phe 
    290                 295                 300                 


Phe Thr Ser Gly Tyr Ile Pro Ala Arg Leu Pro Ile Thr Cys Leu Thr 
305                 310                 315                 320 


Ile Pro Pro Arg Phe Ser Ile Ala Pro Ser Ser Leu Asp Pro Ser Asn 
                325                 330                 335     


Arg Lys Pro Leu Thr Val Leu Asn Lys Gly Leu Glu Asn Pro Leu Pro 
            340                 345                 350         


Glu Arg Pro Arg Glu Lys Glu Glu Pro Val Val Arg Glu Thr Gly Glu 
        355                 360                 365             


Val Val Asp Cys His Leu Ser Asp Met Leu Gln Gln Leu His Ser Val 
    370                 375                 380                 


Asn Ala Ser Lys Pro Ser Glu Arg Gly Leu Val Arg Gln Glu Glu Ala 
385                 390                 395                 400 


Glu Asp Pro Ala Cys Ile Pro Ile Phe Trp Val Ser Lys Trp Val Asp 
                405                 410                 415     


Tyr Ser Asp Lys Tyr Gly Leu Gly Tyr Gln Leu Cys Asp Asn Ser Val 
            420                 425                 430         


Gly Val Leu Phe Asn Asp Ser Thr Arg Leu Ile Leu Tyr Asn Asp Gly 
        435                 440                 445             


Asp Ser Leu Gln Tyr Ile Glu Arg Asp Gly Thr Glu Ser Tyr Leu Thr 
    450                 455                 460                 


Val Ser Ser His Pro Asn Ser Leu Met Lys Lys Ile Thr Leu Leu Lys 
465                 470                 475                 480 


Tyr Phe Arg Asn Tyr Met Ser Glu His Leu Leu Lys Ala Gly Ala Asn 
                485                 490                 495     


Ile Thr Pro Arg Glu Gly Asp Glu Leu Ala Arg Leu Pro Tyr Leu Arg 
            500                 505                 510         


Thr Trp Phe Arg Thr Arg Ser Ala Ile Ile Leu His Leu Ser Asn Gly 
        515                 520                 525             


Ser Val Gln Ile Asn Phe Phe Gln Asp His Thr Lys Leu Ile Leu Cys 
    530                 535                 540                 


Pro Leu Met Ala Ala Val Thr Tyr Ile Asp Glu Lys Arg Asp Phe Arg 
545                 550                 555                 560 


Thr Tyr Arg Leu Ser Leu Leu Glu Glu Tyr Gly Cys Cys Lys Glu Leu 
                565                 570                 575     


Ala Ser Arg Leu Arg Tyr Ala Arg Thr Met Val Asp Lys Leu Leu Ser 
            580                 585                 590         


Ser Arg Ser Ala Ser Asn Arg Leu Lys Ala Ser 
        595                 600             


<210>  43
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gly Phe Gly Ser Asp Leu Lys Asn Ser His Glu Ala Val Leu Lys 
1               5                   10                  15      


Leu Gln Asp Trp Glu Leu Arg Leu Leu Glu Thr Val Lys Lys Phe Met 
            20                  25                  30          


Ala Leu Arg Ile Lys Ser Asp Lys Glu Tyr Ala Ser Thr Leu Gln Asn 
        35                  40                  45              


Leu Cys Asn Gln Val Asp Lys Glu Ser Thr Val Gln Met Asn Tyr Val 
    50                  55                  60                  


Ser Asn Val Ser Lys Ser Trp Leu Leu Met Ile Gln Gln Thr Glu Gln 
65                  70                  75                  80  


Leu Ser Arg Ile Met Lys Thr His Ala Glu Asp Leu Asn Ser Gly Pro 
                85                  90                  95      


Leu His Arg Leu Thr Met Met Ile Lys Asp Lys Gln Gln Val Lys Lys 
            100                 105                 110         


Ser Tyr Ile Gly Val His Gln Gln Ile Glu Ala Glu Met Ile Lys Val 
        115                 120                 125             


Thr Lys Thr Glu Leu Glu Lys Leu Lys Cys Ser Tyr Arg Gln Leu Ile 
    130                 135                 140                 


Lys Glu Met Asn Ser Ala Lys Glu Lys Tyr Lys Glu Ala Leu Ala Lys 
145                 150                 155                 160 


Gly Lys Glu Thr Glu Lys Ala Lys Glu Arg Tyr Asp Lys Ala Thr Met 
                165                 170                 175     


Lys Leu His Met Leu His Asn Gln Tyr Val Leu Ala Leu Lys Gly Ala 
            180                 185                 190         


Gln Leu His Gln Asn Gln Tyr Tyr Asp Ile Thr Leu Pro Leu Leu Leu 
        195                 200                 205             


Asp Ser Leu Gln Lys Met Gln Glu Glu Met Ile Lys Ala Leu Lys Gly 
    210                 215                 220                 


Ile Phe Asp Glu Tyr Ser Gln Ile Thr Ser Leu Val Thr Glu Glu Ile 
225                 230                 235                 240 


Val Asn Val His Lys Glu Ile Gln Met Ser Val Glu Gln Ile Asp Pro 
                245                 250                 255     


Ser Thr Glu Tyr Asn Asn Phe Ile Asp Val His Arg Thr Thr Ala Ala 
            260                 265                 270         


Lys Glu Gln Glu Ile Glu Phe Asp Thr Ser Leu Leu Glu Glu Asn Glu 
        275                 280                 285             


Asn Leu Gln Ala Asn Glu Ile Met Trp Asn Asn Leu Thr Ala Glu Ser 
    290                 295                 300                 


Leu Gln Val Met Leu Lys Thr Leu Ala Glu Glu Leu Met Gln Thr Gln 
305                 310                 315                 320 


Gln Met Leu Leu Asn Lys Glu Glu Ala Val Leu Glu Leu Glu Lys Arg 
                325                 330                 335     


Ile Glu Glu Ser Ser Glu Thr Cys Glu Lys Lys Ser Asp Ile Val Leu 
            340                 345                 350         


Leu Leu Ser Gln Lys Gln Ala Leu Glu Glu Leu Lys Gln Ser Val Gln 
        355                 360                 365             


Gln Leu Arg Cys Thr Glu Ala Lys Phe Ser Ala Gln Lys Glu Leu Leu 
    370                 375                 380                 


Glu Gln Lys Val Gln Glu Asn Asp Gly Lys Glu Pro Pro Pro Val Val 
385                 390                 395                 400 


Asn Tyr Glu Glu Asp Ala Arg Ser Val Thr Ser Met Glu Arg Lys Glu 
                405                 410                 415     


Arg Leu Ser Lys Phe Glu Ser Ile Arg His Ser Ile Ala Gly Ile Ile 
            420                 425                 430         


Arg Ser Pro Lys Ser Ala Val Gly Ser Ser Ala Leu Ser Asp Met Ile 
        435                 440                 445             


Ser Ile Ser Glu Lys Pro Leu Ala Glu Gln Asp Trp Tyr His Gly Ala 
    450                 455                 460                 


Ile Pro Arg Ile Glu Ala Gln Glu Leu Leu Lys Lys Gln Gly Asp Phe 
465                 470                 475                 480 


Leu Val Arg Glu Ser His Gly Lys Pro Gly Glu Tyr Val Leu Ser Val 
                485                 490                 495     


Tyr Ser Asp Gly Gln Arg Arg His Phe Ile Ile Gln Tyr Val Asp Asn 
            500                 505                 510         


Met Tyr Arg Phe Glu Gly Thr Gly Phe Ser Asn Ile Pro Gln Leu Ile 
        515                 520                 525             


Asp His His Tyr Thr Thr Lys Gln Val Ile Thr Lys Lys Ser Gly Val 
    530                 535                 540                 


Val Leu Leu Asn Pro Ile Pro Lys Asp Lys Lys Trp Ile Leu Ser His 
545                 550                 555                 560 


Glu Asp Val Ile Leu Gly Glu Leu Leu Gly Lys Gly Asn Phe Gly Glu 
                565                 570                 575     


Val Tyr Lys Gly Thr Leu Lys Asp Lys Thr Ser Val Ala Val Lys Thr 
            580                 585                 590         


Cys Lys Glu Asp Leu Pro Gln Glu Leu Lys Ile Lys Phe Leu Gln Glu 
        595                 600                 605             


Ala Lys Ile Leu Lys Gln Tyr Asp His Pro Asn Ile Val Lys Leu Ile 
    610                 615                 620                 


Gly Val Cys Thr Gln Arg Gln Pro Val Tyr Ile Ile Met Glu Leu Val 
625                 630                 635                 640 


Ser Gly Gly Asp Phe Leu Thr Phe Leu Arg Arg Lys Lys Asp Glu Leu 
                645                 650                 655     


Lys Leu Lys Gln Leu Val Lys Phe Ser Leu Asp Ala Ala Ala Gly Met 
            660                 665                 670         


Leu Tyr Leu Glu Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg 
        675                 680                 685             


Asn Cys Leu Val Gly Glu Asn Asn Val Leu Lys Ile Ser Asp Phe Gly 
    690                 695                 700                 


Met Ser Arg Gln Glu Asp Gly Gly Val Tyr Ser Ser Ser Gly Leu Lys 
705                 710                 715                 720 


Gln Ile Pro Ile Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg 
                725                 730                 735     


Tyr Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu 
            740                 745                 750         


Thr Phe Ser Leu Gly Val Cys Pro Tyr Pro Gly Met Thr Asn Gln Gln 
        755                 760                 765             


Ala Arg Glu Gln Val Glu Arg Gly Tyr Arg Met Ser Ala Pro Gln His 
    770                 775                 780                 


Cys Pro Glu Asp Ile Ser Lys Ile Met Met Lys Cys Trp Asp Tyr Lys 
785                 790                 795                 800 


Pro Glu Asn Arg Pro Lys Phe Ser Glu Leu Gln Lys Glu Leu Thr Ile 
                805                 810                 815     


Ile Lys Arg Lys Leu Thr 
            820         


<210>  44
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Gln Glu Thr Asn Gln Thr Pro Gly Pro Met Leu Cys Ser Thr 
1               5                   10                  15      


Gly Cys Gly Phe Tyr Gly Asn Pro Arg Thr Asn Gly Met Cys Ser Val 
            20                  25                  30          


Cys Tyr Lys Glu His Leu Gln Arg Gln Gln Asn Ser Gly Arg Met Ser 
        35                  40                  45              


Pro Met Gly Thr Ala Ser Gly Ser Asn Ser Pro Thr Ser Asp Ser Ala 
    50                  55                  60                  


Ser Val Gln Arg Ala Asp Thr Ser Leu Asn Asn Cys Glu Gly Ala Ala 
65                  70                  75                  80  


Gly Ser Thr Ser Glu Lys Ser Arg Asn Val Pro Val Ala Ala Leu Pro 
                85                  90                  95      


Val Thr Gln Gln Met Thr Glu Met Ser Ile Ser Arg Glu Asp Lys Ile 
            100                 105                 110         


Thr Thr Pro Lys Thr Glu Val Ser Glu Pro Val Val Thr Gln Pro Ser 
        115                 120                 125             


Pro Ser Val Ser Gln Pro Ser Thr Ser Gln Ser Glu Glu Lys Ala Pro 
    130                 135                 140                 


Glu Leu Pro Lys Pro Lys Lys Asn Arg Cys Phe Met Cys Arg Lys Lys 
145                 150                 155                 160 


Val Gly Leu Thr Gly Phe Asp Cys Arg Cys Gly Asn Leu Phe Cys Gly 
                165                 170                 175     


Leu His Arg Tyr Ser Asp Lys His Asn Cys Pro Tyr Asp Tyr Lys Ala 
            180                 185                 190         


Glu Ala Ala Ala Lys Ile Arg Lys Glu Asn Pro Val Val Val Ala Glu 
        195                 200                 205             


Lys Ile Gln Arg Ile 
    210             


<210>  45
<211>  1068
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Met  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210>  46
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Ala Glu Val Pro Glu Ala Ala Ser Ala Glu Glu Gln Lys Glu 
1               5                   10                  15      


Met Glu Asp Lys Val Thr Ser Pro Glu Lys Ala Glu Glu Ala Lys Leu 
            20                  25                  30          


Lys Ala Arg Tyr Pro His Leu Gly Gln Lys Pro Gly Gly Ser Asp Phe 
        35                  40                  45              


Leu Arg Lys Arg Leu Gln Lys Gly Gln Lys Tyr Phe Asp Ser Gly Asp 
    50                  55                  60                  


Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys Gln Leu Pro Thr Ala 
65                  70                  75                  80  


Ala Pro Asp Lys Thr Glu Val Thr Gly Asp His Ile Pro Thr Pro Gln 
                85                  90                  95      


Asp Leu Pro Gln Arg Lys Pro Ser Leu Val Ala Ser Lys Leu Ala Gly 
            100                 105                 110         


<210>  47
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Gln Val Asn Glu Leu Lys Glu Lys Gly Asn Lys Ala Leu Ser 
1               5                   10                  15      


Val Gly Asn Ile Asp Asp Ala Leu Gln Cys Tyr Ser Glu Ala Ile Lys 
            20                  25                  30          


Leu Asp Pro His Asn His Val Leu Tyr Ser Asn Arg Ser Ala Ala Tyr 
        35                  40                  45              


Ala Lys Lys Gly Asp Tyr Gln Lys Ala Tyr Glu Asp Gly Cys Lys Thr 
    50                  55                  60                  


Val Asp Leu Lys Pro Asp Trp Gly Lys Gly Tyr Ser Arg Lys Ala Ala 
65                  70                  75                  80  


Ala Leu Glu Phe Leu Asn Arg Phe Glu Glu Ala Lys Arg Thr Tyr Glu 
                85                  90                  95      


Glu Gly Leu Lys His Glu Ala Asn Asn Pro Gln Leu Lys Glu Gly Leu 
            100                 105                 110         


Gln Asn Met Glu Ala Arg Leu Ala Glu Arg Lys Phe Met Asn Pro Phe 
        115                 120                 125             


Asn Met Pro Asn Leu Tyr Gln Lys Leu Glu Ser Asp Pro Arg Thr Arg 
    130                 135                 140                 


Thr Leu Leu Ser Asp Pro Thr Tyr Arg Glu Leu Ile Glu Gln Leu Arg 
145                 150                 155                 160 


Asn Lys Pro Ser Asp Leu Gly Thr Lys Leu Gln Asp Pro Arg Ile Met 
                165                 170                 175     


Thr Thr Leu Ser Val Leu Leu Gly Val Asp Leu Gly Ser Met Asp Glu 
            180                 185                 190         


Glu Glu Glu Ile Ala Thr Pro Pro Pro Pro Pro Pro Pro Lys Lys Glu 
        195                 200                 205             


Thr Lys Pro Glu Pro Met Glu Glu Asp Leu Pro Glu Asn Lys Lys Gln 
    210                 215                 220                 


Ala Leu Lys Glu Lys Glu Leu Gly Asn Asp Ala Tyr Lys Lys Lys Asp 
225                 230                 235                 240 


Phe Asp Thr Ala Leu Lys His Tyr Asp Lys Ala Lys Glu Leu Asp Pro 
                245                 250                 255     


Thr Asn Met Thr Tyr Ile Thr Asn Gln Ala Ala Val Tyr Phe Glu Lys 
            260                 265                 270         


Gly Asp Tyr Asn Lys Cys Arg Glu Leu Cys Glu Lys Ala Ile Glu Val 
        275                 280                 285             


Gly Arg Glu Asn Arg Glu Asp Tyr Arg Gln Ile Ala Lys Ala Tyr Ala 
    290                 295                 300                 


Arg Ile Gly Asn Ser Tyr Phe Lys Glu Glu Lys Tyr Lys Asp Ala Ile 
305                 310                 315                 320 


His Phe Tyr Asn Lys Ser Leu Ala Glu His Arg Thr Pro Asp Val Leu 
                325                 330                 335     


Lys Lys Cys Gln Gln Ala Glu Lys Ile Leu Lys Glu Gln Glu Arg Leu 
            340                 345                 350         


Ala Tyr Ile Asn Pro Asp Leu Ala Leu Glu Glu Lys Asn Lys Gly Asn 
        355                 360                 365             


Glu Cys Phe Gln Lys Gly Asp Tyr Pro Gln Ala Met Lys His Tyr Thr 
    370                 375                 380                 


Glu Ala Ile Lys Arg Asn Pro Lys Asp Ala Lys Leu Tyr Ser Asn Arg 
385                 390                 395                 400 


Ala Ala Cys Tyr Thr Lys Leu Leu Glu Phe Gln Leu Ala Leu Lys Asp 
                405                 410                 415     


Cys Glu Glu Cys Ile Gln Leu Glu Pro Thr Phe Ile Lys Gly Tyr Thr 
            420                 425                 430         


Arg Lys Ala Ala Ala Leu Glu Ala Met Lys Asp Tyr Thr Lys Ala Met 
        435                 440                 445             


Asp Val Tyr Gln Lys Ala Leu Asp Leu Asp Ser Ser Cys Lys Glu Ala 
    450                 455                 460                 


Ala Asp Gly Tyr Gln Arg Cys Met Met Ala Gln Tyr Asn Arg His Asp 
465                 470                 475                 480 


Ser Pro Glu Asp Val Lys Arg Arg Ala Met Ala Asp Pro Glu Val Gln 
                485                 490                 495     


Gln Ile Met Ser Asp Pro Ala Met Arg Leu Ile Leu Glu Gln Met Gln 
            500                 505                 510         


Lys Asp Pro Gln Ala Leu Ser Glu His Leu Lys Asn Pro Val Ile Ala 
        515                 520                 525             


Gln Lys Ile Gln Lys Leu Met Asp Val Gly Leu Ile Ala Ile Arg 
    530                 535                 540             


<210>  48
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gly Trp Ile Thr Glu Asp Leu Ile Arg Arg Asn Ala Glu His Asn 
1               5                   10                  15      


Asp Cys Val Ile Phe Ser Leu Glu Glu Leu Ser Leu His Gln Gln Glu 
            20                  25                  30          


Ile Glu Arg Leu Glu His Ile Asp Lys Trp Cys Arg Asp Leu Lys Ile 
        35                  40                  45              


Leu Tyr Leu Gln Asn Asn Leu Ile Gly Lys Ile Glu Asn Val Ser Lys 
    50                  55                  60                  


Leu Lys Lys Leu Glu Tyr Leu Asn Leu Ala Leu Asn Asn Ile Glu Lys 
65                  70                  75                  80  


Ile Glu Asn Leu Glu Gly Cys Glu Glu Leu Ala Lys Leu Asp Leu Thr 
                85                  90                  95      


Val Asn Phe Ile Gly Glu Leu Ser Ser Ile Lys Asn Leu Gln His Asn 
            100                 105                 110         


Ile His Leu Lys Glu Leu Phe Leu Met Gly Asn Pro Cys Ala Ser Phe 
        115                 120                 125             


Asp His Tyr Arg Glu Phe Val Val Ala Thr Leu Pro Gln Leu Lys Trp 
    130                 135                 140                 


Leu Asp Gly Lys Glu Ile Glu Pro Ser Glu Arg Ile Lys Ala Leu Gln 
145                 150                 155                 160 


Asp Tyr Ser Val Ile Glu Pro Gln Ile Arg Glu Gln Glu Lys Asp His 
                165                 170                 175     


Cys Leu Lys Arg Ala Lys Leu Lys Glu Glu Ala Gln Arg Lys His Gln 
            180                 185                 190         


Glu Glu Asp Lys Asn Glu Asp Lys Arg Ser Asn Ala Gly Phe Asp Gly 
        195                 200                 205             


Arg Trp Tyr Thr Asp Ile Asn Ala Thr Leu Ser Ser Leu Glu Ser Lys 
    210                 215                 220                 


Asp His Leu Gln Ala Pro Asp Ile Glu Glu His Asn Thr Lys Lys Leu 
225                 230                 235                 240 


Asp Asp Asp Leu Glu Phe Trp Asn Lys Pro Cys Leu Phe Thr Pro Glu 
                245                 250                 255     


Ser Arg Leu Glu Thr Leu Arg His Met Glu Lys Gln Arg Lys Lys Gln 
            260                 265                 270         


Glu Lys Leu Ser Glu Lys Lys Lys Lys Val Lys Pro Pro Arg Thr Leu 
        275                 280                 285             


Ile Thr Glu Asp Gly Lys Ala Leu Asn Val Asn Glu Pro Lys Ile Asp 
    290                 295                 300                 


Phe Ser Leu Lys Asp Asn Glu Lys Gln Ile Ile Leu Asp Leu Ala Val 
305                 310                 315                 320 


Tyr Arg Tyr Met Asp Thr Ser Leu Ile Asp Val Asp Val Gln Pro Thr 
                325                 330                 335     


Tyr Val Arg Val Met Ile Lys Gly Lys Pro Phe Gln Leu Val Leu Pro 
            340                 345                 350         


Ala Glu Val Lys Pro Asp Ser Ser Ser Ala Lys Arg Ser Gln Thr Thr 
        355                 360                 365             


Gly His Leu Val Ile Cys Met Pro Lys Val Gly Glu Val Ile Thr Gly 
    370                 375                 380                 


Gly Gln Arg Ala Phe Lys Ser Met Lys Thr Thr Ser Asp Arg Ser Arg 
385                 390                 395                 400 


Glu Gln Thr Asn Thr Arg Ser Lys His Met Glu Lys Leu Glu Val Asp 
                405                 410                 415     


Pro Ser Lys His Ser Phe Pro Asp Val Thr Asn Ile Val Gln Glu Lys 
            420                 425                 430         


Lys His Thr Pro Arg Arg Arg Pro Glu Pro Lys Ile Ile Pro Ser Glu 
        435                 440                 445             


Glu Asp Pro Thr Phe Glu Asp Asn Pro Glu Val Pro Pro Leu Ile 
    450                 455                 460             


<210>  49
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Asp Lys Tyr Asp Asp Leu Gly Leu Glu Ala Ser Lys Phe Ile Glu 
1               5                   10                  15      


Asp Leu Asn Met Tyr Glu Ala Ser Lys Asp Gly Leu Phe Arg Val Asp 
            20                  25                  30          


Lys Gly Ala Gly Asn Asn Pro Glu Phe Glu Glu Thr Arg Arg Val Phe 
        35                  40                  45              


Ala Thr Lys Met Ala Lys Ile His Leu Gln Gln Gln Gln Gln Gln Leu 
    50                  55                  60                  


Leu Gln Glu Glu Thr Leu Pro Arg Gly Ser Arg Gly Pro Val Asn Gly 
65                  70                  75                  80  


Gly Gly Arg Leu Gly Pro Gln Ala Arg Trp Glu Val Val Gly Ser Lys 
                85                  90                  95      


Leu Thr Val Asp Gly Ala Ala Lys Pro Pro Leu Ala Ala Ser Thr Gly 
            100                 105                 110         


Ala Pro Gly Ala Val Thr Thr Leu Ala Ala Gly Gln Pro Pro Tyr Pro 
        115                 120                 125             


Pro Gln Glu Gln Arg Ser Arg Pro Tyr Leu His Gly Thr Arg His Gly 
    130                 135                 140                 


Ser Gln Asp Cys Gly Ser Arg Glu Ser Leu Ala Thr Ser Glu Met Ser 
145                 150                 155                 160 


Ala Phe His Gln Pro Gly Pro Cys Glu Asp Pro Ser Cys Leu Thr His 
                165                 170                 175     


Gly Asp Tyr Tyr Asp Asn Leu Ser Leu Ala Ser Pro Lys Trp Gly Asp 
            180                 185                 190         


Lys Pro Gly Val Ser Pro Ser Ile Gly Leu Ser Val Gly Ser Gly Trp 
        195                 200                 205             


Pro Ser Ser Pro Gly Ser Asp Pro Pro Leu Pro Lys Pro Cys Gly Asp 
    210                 215                 220                 


His Pro Leu Asn His Arg Gln Leu Ser Leu Ser Ser Ser Arg Ser Ser 
225                 230                 235                 240 


Glu Gly Ser Leu Gly Gly Gln Asn Ser Gly Ile Gly Gly Arg Ser Ser 
                245                 250                 255     


Glu Lys Pro Thr Gly Leu Trp Ser Thr Ala Ser Ser Gln Arg Val Ser 
            260                 265                 270         


Pro Gly Leu Pro Ser Pro Asn Leu Glu Asn Gly Ala Pro Ala Val Gly 
        275                 280                 285             


Pro Val Gln Pro Arg Thr Pro Ser Val Ser Ala Pro Leu Ala Leu Ser 
    290                 295                 300                 


Cys Pro Arg Gln Gly Gly Leu Pro Arg Ser Asn Ser Gly Leu Gly Gly 
305                 310                 315                 320 


Glu Val Ser Gly Val Met Ser Lys Pro Asn Val Asp Pro Gln Pro Trp 
                325                 330                 335     


Phe Gln Asp Gly Pro Lys Ser Tyr Leu Ser Ser Ser Ala Pro Ser Ser 
            340                 345                 350         


Ser Pro Ala Gly Leu Asp Gly Ser Gln Gln Gly Ala Val Pro Gly Leu 
        355                 360                 365             


Gly Pro Lys Pro Gly Cys Thr Asp Leu Gly Thr Gly Pro Lys Leu Ser 
    370                 375                 380                 


Pro Thr Ser Leu Val His Pro Val Met Ser Thr Leu Pro Glu Leu Ser 
385                 390                 395                 400 


Cys Lys Glu Gly Pro Leu Gly Trp Ser Ser Asp Gly Ser Leu Gly Ser 
                405                 410                 415     


Val Leu Leu Asp Ser Pro Ser Ser Pro Arg Val Arg Leu Pro Cys Gln 
            420                 425                 430         


Pro Leu Val Pro Gly Pro Glu Leu Arg Pro Ser Ala Ala Glu Leu Lys 
        435                 440                 445             


Leu Glu Ala Leu Thr Gln Arg Leu Glu Arg Glu Met Asp Ala His Pro 
    450                 455                 460                 


Lys Ala Asp Tyr Phe Gly Ala Cys Val Lys Cys Ser Lys Gly Val Phe 
465                 470                 475                 480 


Gly Ala Gly Gln Ala Cys Gln Ala Met Gly Asn Leu Tyr His Asp Thr 
                485                 490                 495     


Cys Phe Thr Cys Ala Ala Cys Ser Arg Lys Leu Arg Gly Lys Ala Phe 
            500                 505                 510         


Tyr Phe Val Asn Gly Lys Val Phe Cys Glu Glu Asp Phe Leu Tyr Ser 
        515                 520                 525             


Gly Phe Gln Gln Ser Ala Asp Arg Cys Phe Leu Cys Gly His Leu Ile 
    530                 535                 540                 


Met Asp Met Ile Leu Gln Ala Leu Gly Lys Ser Tyr His Pro Gly Cys 
545                 550                 555                 560 


Phe Arg Cys Val Ile Cys Asn Glu Cys Leu Asp Gly Val Pro Phe Thr 
                565                 570                 575     


Val Asp Ser Glu Asn Lys Ile Tyr Cys Val Arg Asp Tyr His Lys Val 
            580                 585                 590         


Leu Ala Pro Lys Cys Ala Ala Cys Gly Leu Pro Ile Leu Pro Pro Glu 
        595                 600                 605             


Gly Ser Asp Glu Thr Ile Arg Val Val Ser Met Asp Arg Asp Tyr His 
    610                 615                 620                 


Val Glu Cys Tyr His Cys Glu Asp Cys Gly Leu Glu Leu Asn Asp Glu 
625                 630                 635                 640 


Asp Gly His Arg Cys Tyr Pro Leu Glu Asp His Leu Phe Cys His Ser 
                645                 650                 655     


Cys His Val Lys Arg Leu Glu Lys Arg Pro Ser Ser Thr Ala Leu His 
            660                 665                 670         


Gln His His Phe 
        675     


<210>  50
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Asp Val Glu Asp Gly Glu Glu Thr Cys Ala Leu Ala Ser His 
1               5                   10                  15      


Ser Gly Ser Ser Gly Ser Lys Ser Gly Gly Asp Lys Met Phe Ser Leu 
            20                  25                  30          


Lys Lys Trp Asn Ala Val Ala Met Trp Ser Trp Asp Val Glu Cys Asp 
        35                  40                  45              


Thr Cys Ala Ile Cys Arg Val Gln Val Met Asp Ala Cys Leu Arg Cys 
    50                  55                  60                  


Gln Ala Glu Asn Lys Gln Glu Asp Cys Val Val Val Trp Gly Glu Cys 
65                  70                  75                  80  


Asn His Ser Phe His Asn Cys Cys Met Ser Leu Trp Val Lys Gln Asn 
                85                  90                  95      


Asn Arg Cys Pro Leu Cys Gln Gln Asp Trp Val Val Gln Arg Ile Gly 
            100                 105                 110         


Lys 
    


<210>  51
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Thr Ser Glu Ser Thr Ser Pro Pro Val Val Pro Pro Leu His Ser 
1               5                   10                  15      


Pro Lys Ser Pro Val Trp Pro Thr Phe Pro Phe His Arg Glu Gly Ser 
            20                  25                  30          


Arg Val Trp Glu Arg Gly Gly Val Pro Pro Arg Asp Leu Pro Ser Pro 
        35                  40                  45              


Leu Pro Thr Lys Arg Thr Arg Thr Tyr Ser Ala Thr Ala Arg Ala Ser 
    50                  55                  60                  


Ala Gly Pro Val Phe Lys Gly Val Cys Lys Gln Phe Ser Arg Ser Gln 
65                  70                  75                  80  


Gly His Gly Phe Ile Thr Pro Glu Asn Gly Ser Glu Asp Ile Phe Val 
                85                  90                  95      


His Val Ser Asp Ile Glu Gly Glu Tyr Val Pro Val Glu Gly Asp Glu 
            100                 105                 110         


Val Thr Tyr Lys Met Cys Pro Ile Pro Pro Lys Asn Gln Lys Phe Gln 
        115                 120                 125             


Ala Val Glu Val Val Leu Thr Gln Leu Ala Pro His Thr Pro His Glu 
    130                 135                 140                 


Thr Trp Ser Gly Gln Val Val Gly Ser 
145                 150             


<210>  52
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Val His Phe Cys Gly Leu Leu Thr Leu His Arg Glu Pro Val Pro 
1               5                   10                  15      


Leu Lys Ser Ile Ser Val Ser Val Asn Ile Tyr Glu Phe Val Ala Gly 
            20                  25                  30          


Val Ser Ala Thr Leu Asn Tyr Glu Asn Glu Glu Lys Val Pro Leu Glu 
        35                  40                  45              


Ala Phe Phe Val Phe Pro Met Asp Glu Asp Ser Ala Val Tyr Ser Phe 
    50                  55                  60                  


Glu Ala Leu Val Asp Gly Lys Lys Ile Val Ala Glu Leu Gln Asp Lys 
65                  70                  75                  80  


Met Lys Ala Arg Thr Asn Tyr Glu Lys Ala Ile Ser Gln Gly His Gln 
                85                  90                  95      


Ala Phe Leu Leu Glu Gly Asp Ser Ser Ser Arg Asp Val Phe Ser Cys 
            100                 105                 110         


Asn Val Gly Asn Leu Gln Pro Gly Ser Lys Ala Ala Val Thr Leu Lys 
        115                 120                 125             


Tyr Val Gln Glu Leu Pro Leu Glu Ala Asp Gly Ala Leu Arg Phe Val 
    130                 135                 140                 


Leu Pro Ala Val Leu Asn Pro Arg Tyr Gln Phe Ser Gly Ser Ser Lys 
145                 150                 155                 160 


Asp Ser Cys Leu Asn Val Lys Thr Pro Ile Val Pro Val Glu Asp Leu 
                165                 170                 175     


Pro Tyr Thr Leu Ser Met Val Ala Thr Ile Asp Ser Gln His Gly Ile 
            180                 185                 190         


Glu Lys Val Gln Ser Asn Cys Pro Leu Ser Pro Thr Glu Tyr Leu Gly 
        195                 200                 205             


Glu Asp Lys Thr Ser Ala Gln Val Ser Leu Ala Ala Gly His Lys Phe 
    210                 215                 220                 


Asp Arg Asp Val Glu Leu Leu Ile Tyr Tyr Asn Glu Val His Thr Pro 
225                 230                 235                 240 


Ser Val Val Leu Glu Met Gly Met Pro Asn Met Lys Pro Gly His Leu 
                245                 250                 255     


Met Gly Asp Pro Ser Ala Met Val Ser Phe Tyr Pro Asn Ile Pro Glu 
            260                 265                 270         


Asp Gln Pro Ser Asn Thr Cys Gly Glu Phe Ile Phe Leu Met Asp Arg 
        275                 280                 285             


Ser Gly Ser Met Gln Ser Pro Met Ser Ser Gln Asp Thr Ser Gln Leu 
    290                 295                 300                 


Arg Ile Gln Ala Ala Lys Glu Thr Leu Ile Leu Leu Leu Lys Ser Leu 
305                 310                 315                 320 


Pro Ile Gly Cys Tyr Phe Asn Ile Tyr Gly Phe Gly Ser Ser Tyr Glu 
                325                 330                 335     


Ala Cys Phe Pro Glu Ser Val Lys Tyr Thr Gln Gln Thr Met Glu Glu 
            340                 345                 350         


Ala Leu Gly Arg Val Lys Leu Met Gln Ala Asp Leu Gly Gly Thr Glu 
        355                 360                 365             


Ile Leu Ala Pro Leu Gln Asn Ile Tyr Arg Gly Pro Ser Ile Pro Gly 
    370                 375                 380                 


His Pro Leu Gln Leu Phe Val Phe Thr Asp Gly Glu Val Thr Asp Thr 
385                 390                 395                 400 


Phe Ser Val Ile Lys Glu Val Arg Ile Asn Arg Gln Lys His Arg Cys 
                405                 410                 415     


Phe Ser Phe Gly Ile Gly Glu Gly Thr Ser Thr Ser Leu Ile Lys Gly 
            420                 425                 430         


Ile Ala Arg Ala Ser Gly Gly Thr Ser Glu Phe Ile Thr Gly Lys Asp 
        435                 440                 445             


Arg Met Gln Ser Lys Ala Leu Arg Thr Leu Lys Arg Ser Leu Gln Pro 
    450                 455                 460                 


Val Val Glu Asp Val Ser Leu Ser Trp His Leu Pro Pro Gly Leu Ser 
465                 470                 475                 480 


Ala Lys Met Leu Ser Pro Glu Gln Thr Val Ile Phe Arg Gly Gln Arg 
                485                 490                 495     


Leu Ile Ser Tyr Ala Gln Leu Thr Gly Arg Met Pro Ala Ala Glu Thr 
            500                 505                 510         


Thr Gly Glu Val Cys Leu Lys Tyr Thr Leu Gln Gly Lys Thr Phe Glu 
        515                 520                 525             


Asp Lys Val Thr Phe Pro Leu Gln Pro Lys Pro Asp Val Asn Leu Thr 
    530                 535                 540                 


Ile His Arg Leu Ala Ala Lys Ser Leu Leu Gln Thr Lys Asp Met Gly 
545                 550                 555                 560 


Leu Arg Glu Thr Pro Ala Ser Asp Lys Lys Asp Ala Leu Asn Leu Ser 
                565                 570                 575     


Leu Glu Ser Gly Val Ile Ser Ser Phe Thr Ala Phe Ile Ala Ile Asn 
            580                 585                 590         


Lys Glu Leu Asn Lys Pro Val Gln Gly Pro Leu Ala His Arg Asp Val 
        595                 600                 605             


Pro Arg Pro Ile Leu Leu Gly Ala Ser Ala Pro Leu Lys Ile Lys Cys 
    610                 615                 620                 


Gln Ser Gly Phe Arg Lys Ala Leu His Ser Asp Arg Pro Pro Ser Ala 
625                 630                 635                 640 


Ser Gln Pro Arg Gly Glu Leu Met Cys Tyr Lys Ala Lys Thr Phe Gln 
                645                 650                 655     


Met Asp Asp Tyr Ser Leu Cys Gly Leu Ile Ser His Lys Asp Gln His 
            660                 665                 670         


Ser Pro Gly Phe Gly Glu Asn His Leu Val Gln Leu Ile Tyr His Gln 
        675                 680                 685             


Asn Ala Asn Gly Ser Trp Asp Leu Asn Glu Asp Leu Ala Lys Ile Leu 
    690                 695                 700                 


Gly Met Ser Leu Glu Glu Ile Met Ala Ala Gln Pro Ala Glu Leu Val 
705                 710                 715                 720 


Asp Ser Ser Gly Trp Ala Thr Ile Leu Ala Val Ile Trp Leu His Ser 
                725                 730                 735     


Asn Gly Lys Asp Leu Lys Cys Glu Trp Glu Leu Leu Glu Arg Lys Ala 
            740                 745                 750         


Val Ala Trp Met Arg Ala His Ala Gly Ser Thr Met Pro Ser Val Val 
        755                 760                 765             


Lys Ala Ala Ile Thr Phe Leu Lys Ser Ser Val Asp Pro Ala Ile Phe 
    770                 775                 780                 


Ala Phe 
785     


<210>  53
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Pro Lys Gly Gly Arg Lys Gly Gly His Lys Gly Arg Ala Arg Gln 
1               5                   10                  15      


Tyr Thr Ser Pro Glu Glu Ile Asp Ala Gln Leu Gln Ala Glu Lys Gln 
            20                  25                  30          


Lys Ala Arg Glu Glu Glu Glu Gln Lys Glu Gly Gly Asp Gly Ala Ala 
        35                  40                  45              


Gly Asp Pro Lys Lys Glu Lys Lys Ser Leu Asp Ser Asp Glu Ser Glu 
    50                  55                  60                  


Asp Glu Glu Asp Asp Tyr Gln Gln Lys Arg Lys Gly Val Glu Gly Leu 
65                  70                  75                  80  


Ile Asp Ile Glu Asn Pro Asn Arg Val Ala Gln Thr Thr Lys Lys Val 
                85                  90                  95      


Thr Gln Leu Asp Leu Asp Gly Pro Lys Glu Leu Ser Arg Arg Glu Arg 
            100                 105                 110         


Glu Glu Ile Glu Lys Gln Lys Ala Lys Glu Arg Tyr Met Lys Met His 
        115                 120                 125             


Leu Ala Gly Lys Thr Glu Gln Ala Lys Ala Asp Leu Ala Arg Leu Ala 
    130                 135                 140                 


Ile Ile Arg Lys Gln Arg Glu Glu Ala Ala Arg Lys Lys Glu Glu Glu 
145                 150                 155                 160 


Arg Lys Ala Lys Asp Asp Ala Thr Leu Ser Gly Lys Arg Met Gln Ser 
                165                 170                 175     


Leu Ser Leu Asn Lys 
            180     


<210>  54
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Ser Lys Arg Lys Ser Thr Thr Pro Cys Met Val Arg Thr Ser 
1               5                   10                  15      


Gln Val Val Glu Gln Asp Val Pro Glu Glu Val Asp Arg Ala Lys Glu 
            20                  25                  30          


Lys Gly Ile Gly Thr Pro Gln Pro Asp Val Ala Lys Asp Ser Trp Ala 
        35                  40                  45              


Ala Glu Leu Glu Asn Ser Ser Lys Glu Asn Glu Val Ile Glu Val Lys 
    50                  55                  60                  


Ser Met Gly Glu Ser Gln Ser Lys Lys Leu Gln Gly Gly Tyr Glu Cys 
65                  70                  75                  80  


Lys Tyr Cys Pro Tyr Ser Thr Gln Asn Leu Asn Glu Phe Thr Glu His 
                85                  90                  95      


Val Asp Met Gln His Pro Asn Val Ile Leu Asn Pro Leu Tyr Val Cys 
            100                 105                 110         


Ala Glu Cys Asn Phe Thr Thr Lys Lys Tyr Asp Ser Leu Ser Asp His 
        115                 120                 125             


Asn Ser Lys Phe His Pro Gly Glu Ala Asn Phe Lys Leu Lys Leu Ile 
    130                 135                 140                 


Lys Arg Asn Asn Gln Thr Val Leu Glu Gln Ser Ile Glu Thr Thr Asn 
145                 150                 155                 160 


His Val Val Ser Ile Thr Thr Ser Gly Pro Gly Thr Gly Asp Ser Asp 
                165                 170                 175     


Ser Gly Ile Ser Val Ser Lys Thr Pro Ile Met Lys Pro Gly Lys Pro 
            180                 185                 190         


Lys Ala Asp Ala Lys Lys Val Pro Lys Lys Pro Glu Glu Ile Thr Pro 
        195                 200                 205             


Glu Asn His Val Glu Gly Thr Ala Arg Leu Val Thr Asp Thr Ala Glu 
    210                 215                 220                 


Ile Leu Ser Arg Leu Gly Gly Val Glu Leu Leu Gln Asp Thr Leu Gly 
225                 230                 235                 240 


His Val Met Pro Ser Val Gln Leu Pro Pro Asn Ile Asn Leu Val Pro 
                245                 250                 255     


Lys Val Pro Val Pro Leu Asn Thr Thr Lys Tyr Asn Ser Ala Leu Asp 
            260                 265                 270         


Thr Asn Ala Thr Met Ile Asn Ser Phe Asn Lys Phe Pro Tyr Pro Thr 
        275                 280                 285             


Gln Ala Glu Leu Ser Trp Leu Thr Ala Ala Ser Lys His Pro Glu Glu 
    290                 295                 300                 


His Ile Arg Ile Trp Phe Ala Thr Gln Arg Leu Lys His Gly Ile Ser 
305                 310                 315                 320 


Trp Ser Pro Glu Glu Val Glu Glu Ala Arg Lys Lys Met Phe Asn Gly 
                325                 330                 335     


Thr Ile Gln Ser Val Pro Pro Thr Ile Thr Val Leu Pro Ala Gln Leu 
            340                 345                 350         


Ala Pro Thr Lys Val Thr Gln Pro Ile Leu Gln Thr Ala Leu Pro Cys 
        355                 360                 365             


Gln Ile Leu Gly Gln Thr Ser Leu Val Leu Thr Gln Val Thr Ser Gly 
    370                 375                 380                 


Ser Thr Thr Val Ser Cys Ser Pro Ile Thr Leu Ala Val Ala Gly Val 
385                 390                 395                 400 


Thr Asn His Gly Gln Lys Arg Pro Leu Val Thr Pro Gln Ala Ala Pro 
                405                 410                 415     


Glu Pro Lys Arg Pro His Ile Ala Gln Val Pro Glu Pro Pro Pro Lys 
            420                 425                 430         


Val Ala Asn Pro Pro Leu Thr Pro Ala Ser Asp Arg Lys Lys Thr Lys 
        435                 440                 445             


Glu Gln Ile Ala His Leu Lys Ala Ser Phe Leu Gln Ser Gln Phe Pro 
    450                 455                 460                 


Asp Asp Ala Glu Val Tyr Arg Leu Ile Glu Val Thr Gly Leu Ala Arg 
465                 470                 475                 480 


Ser Glu Ile Lys Lys Trp Phe Ser Asp His Arg Tyr Arg Cys Gln Arg 
                485                 490                 495     


Gly Ile Val His Ile Thr Ser Glu Ser Leu Ala Lys Asp Gln Leu Ala 
            500                 505                 510         


Ile Ala Ala Ser Arg His Gly Arg Thr Tyr His Ala Tyr Pro Asp Phe 
        515                 520                 525             


Ala Pro Gln Lys Phe Lys Glu Lys Thr Gln Gly Gln Val Lys Ile Leu 
    530                 535                 540                 


Glu Asp Ser Phe Leu Lys Ser Ser Phe Pro Thr Gln Ala Glu Leu Asp 
545                 550                 555                 560 


Arg Leu Arg Val Glu Thr Lys Leu Ser Arg Arg Glu Ile Asp Ser Trp 
                565                 570                 575     


Phe Ser Glu Arg Arg Lys Leu Arg Asp Ser Met Glu Gln Ala Val Leu 
            580                 585                 590         


Asp Ser Met Gly Ser Gly Lys Lys Gly Gln Asp Val Gly Ala Pro Asn 
        595                 600                 605             


Gly Ala Leu Ser Arg Leu Asp Gln Leu Ser Gly Ala Gln Leu Thr Ser 
    610                 615                 620                 


Ser Leu Pro Ser Pro Ser Pro Ala Ile Ala Lys Ser Gln Glu Gln Val 
625                 630                 635                 640 


His Leu Leu Arg Ser Thr Phe Ala Arg Thr Gln Trp Pro Thr Pro Gln 
                645                 650                 655     


Glu Tyr Asp Gln Leu Ala Ala Lys Thr Gly Leu Val Arg Thr Glu Ile 
            660                 665                 670         


Val Arg Trp Phe Lys Glu Asn Arg Cys Leu Leu Lys Thr Gly Thr Val 
        675                 680                 685             


Lys Trp Met Glu Gln Tyr Gln His Gln Pro Met Ala Asp Asp His Gly 
    690                 695                 700                 


Tyr Asp Ala Val Ala Arg Lys Ala Thr Lys Pro Met Ala Glu Ser Pro 
705                 710                 715                 720 


Lys Asn Gly Gly Asp Val Val Pro Gln Tyr Tyr Lys Asp Pro Lys Lys 
                725                 730                 735     


Leu Cys Glu Glu Asp Leu Glu Lys Leu Val Thr Arg Val Lys Val Gly 
            740                 745                 750         


Ser Glu Pro Ala Lys Asp Cys Leu Pro Ala Lys Pro Ser Glu Ala Thr 
        755                 760                 765             


Ser Asp Arg Ser Glu Gly Ser Ser Arg Asp Gly Gln Gly Ser Asp Glu 
    770                 775                 780                 


Asn Glu Glu Ser Ser Val Val Asp Tyr Val Glu Val Thr Val Gly Glu 
785                 790                 795                 800 


Glu Asp Ala Ile Ser Asp Arg Ser Asp Ser Trp Ser Gln Ala Ala Ala 
                805                 810                 815     


Glu Gly Val Ser Glu Leu Ala Glu Ser Asp Ser Asp Cys Val Pro Ala 
            820                 825                 830         


Glu Ala Gly Gln Ala 
        835         


<210>  55
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Glu Val Lys Pro Val Gly Glu Pro Thr Gln Glu Val Ser Lys Phe 
1               5                   10                  15      


Lys Leu Ser Thr Lys Val Glu Ser Thr Gly His Trp Leu Val Glu Asp 
            20                  25                  30          


His Val Arg Ile Trp Glu Val Leu Lys Thr Glu Glu Ser Ser Ile Gln 
        35                  40                  45              


Asp Trp Gly Glu Glu Val Glu Glu Gly Ala Val Tyr His Val Thr Leu 
    50                  55                  60                  


Lys Arg Val Gln Ile Gln Gln Ala Ala Asn Lys Gly Ala Arg Trp Leu 
65                  70                  75                  80  


Gly Val Glu Gly Asp Gln Leu Pro Pro Gly His Thr Val Ser Gln Tyr 
                85                  90                  95      


Glu Thr Cys Lys Ile Arg Thr Ile Lys Ala Gly Thr Leu Glu Lys Leu 
            100                 105                 110         


Val Glu Asn Leu Leu Thr Ala Phe Gly Asp Asn Asp Phe Thr Tyr Ile 
        115                 120                 125             


Ser Ile Phe Leu Ser Thr Tyr Arg Gly Phe Ala Ser Thr Lys Glu Val 
    130                 135                 140                 


Leu Glu Leu Leu Leu Asp Arg Tyr Gly Asn Leu Thr Ser Pro Asn Cys 
145                 150                 155                 160 


Glu Glu Asp Gly Ser Gln Ser Ser Ser Glu Ser Lys Met Val Ile Arg 
                165                 170                 175     


Asn Ala Ile Ala Ser Ile Leu Arg Ala Trp Leu Asp Gln Cys Ala Glu 
            180                 185                 190         


Asp Phe Arg Glu Pro Pro His Phe Pro Cys Leu Gln Lys Leu Leu Asp 
        195                 200                 205             


Tyr Leu Thr Arg Met Met Pro Gly Ser Asp Pro Glu Arg Arg Ala Gln 
    210                 215                 220                 


Asn Leu Leu Glu Gln Phe Gln Lys Gln Glu Val Glu Thr Asp Asn Gly 
225                 230                 235                 240 


Leu Pro Asn Thr Ile Ser Phe Ser Leu Glu Glu Glu Glu Glu Leu Glu 
                245                 250                 255     


Gly Gly Glu Ser Ala Glu Phe Thr Cys Phe Ser Glu Asp Leu Val Ala 
            260                 265                 270         


Glu Gln Leu Thr Tyr Met Asp Ala Gln Leu Phe Lys Lys Val Val Pro 
        275                 280                 285             


His His Cys Leu Gly Cys Ile Trp Ser Arg Arg Asp Lys Lys Glu Asn 
    290                 295                 300                 


Lys His Leu Ala Pro Thr Ile Arg Ala Thr Ile Ser Gln Phe Asn Thr 
305                 310                 315                 320 


Leu Thr Lys Cys Val Val Ser Thr Ile Leu Gly Gly Lys Glu Leu Lys 
                325                 330                 335     


Thr Gln Gln Arg Ala Lys Ile Ile Glu Lys Trp Ile Asn Ile Ala His 
            340                 345                 350         


Glu Cys Arg Leu Leu Lys Asn Phe Ser Ser Leu Arg Ala Ile Val Ser 
        355                 360                 365             


Ala Leu Gln Ser Asn Ser Ile Tyr Arg Leu Lys Lys Thr Trp Ala Ala 
    370                 375                 380                 


Val Pro Arg Asp Arg Met Leu Met Phe Glu Glu Leu Ser Asp Ile Phe 
385                 390                 395                 400 


Ser Asp His Asn Asn His Leu Thr Ser Arg Glu Leu Leu Met Lys Glu 
                405                 410                 415     


Gly Thr Ser Lys Phe Ala Asn Leu Asp Ser Ser Val Lys Glu Asn Gln 
            420                 425                 430         


Lys Arg Thr Gln Arg Arg Leu Gln Leu Gln Lys Asp Met Gly Val Met 
        435                 440                 445             


Gln Gly Thr Val Pro Tyr Leu Gly Thr Phe Leu Thr Asp Leu Thr Met 
    450                 455                 460                 


Leu Asp Thr Ala Leu Gln Asp Tyr Ile Glu Gly Gly Leu Ile Asn Phe 
465                 470                 475                 480 


Glu Lys Arg Arg Arg Glu Phe Glu Val Ile Ala Gln Ile Lys Leu Leu 
                485                 490                 495     


Gln Ser Ala Cys Asn Ser Tyr Cys Met Thr Pro Asp Gln Lys Phe Ile 
            500                 505                 510         


Gln Trp Phe Gln Arg Gln Gln Leu Leu Thr Glu Glu Glu Ser Tyr Ala 
        515                 520                 525             


Leu Ser Cys Glu Ile Glu Ala Ala Ala Asp Ala Ser Thr Thr Ser Pro 
    530                 535                 540                 


Lys Pro Arg Lys Ser Met Val Lys Arg Leu Ser Leu Leu Phe Leu Gly 
545                 550                 555                 560 


Ser Asp Met Ile Thr Ser Pro Thr Pro Thr Lys Glu Gln Pro Lys Ser 
                565                 570                 575     


Thr Ala Ser Gly Ser Ser Gly Glu Ser Met Asp Ser Val Ser Val Ser 
            580                 585                 590         


Ser Cys Glu Ser Asn His Ser Glu Ala Glu Glu Gly Ser Ile Thr Pro 
        595                 600                 605             


Met Asp Thr Pro Asp Glu Pro Gln Lys Lys Leu Ser Glu Ser Ser Ser 
    610                 615                 620                 


Ser Cys Ser Ser Ile His Ser Met Asp Thr Asn Ser Ser Gly Met Ser 
625                 630                 635                 640 


Ser Leu Ile Asn Pro Leu Ser Ser Pro Pro Ser Cys Asn Asn Asn Pro 
                645                 650                 655     


Lys Ile His Lys Arg Ser Val Ser Val Thr Ser Ile Thr Ser Thr Val 
            660                 665                 670         


Leu Pro Pro Val Tyr Asn Gln Gln Asn Glu Asp Thr Cys Ile Ile Arg 
        675                 680                 685             


Ile Ser Val Glu Asp Asn Asn Gly Asn Met Tyr Lys Ser Ile Met Leu 
    690                 695                 700                 


Thr Ser Gln Asp Lys Thr Pro Ala Val Ile Gln Arg Ala Met Leu Lys 
705                 710                 715                 720 


His Asn Leu Asp Ser Asp Pro Ala Glu Glu Tyr Glu Leu Val Gln Val 
                725                 730                 735     


Ile Ser Glu Asp Lys Glu Leu Val Ile Pro Asp Ser Ala Asn Val Phe 
            740                 745                 750         


Tyr Ala Met Asn Ser Gln Val Asn Phe Asp Phe Ile Leu Arg Lys Lys 
        755                 760                 765             


Asn Ser Met Glu Glu Gln Val Lys Leu Arg Ser Arg Thr Ser Leu Thr 
    770                 775                 780                 


Leu Pro Arg Thr Ala Lys Arg Gly Cys Trp Ser Tyr Arg His Ser Lys 
785                 790                 795                 800 


Ile Thr Leu 
            


<210>  56
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ser Ser Val Asp Glu Glu Ala Leu His Gln Leu Tyr Leu Trp 
1               5                   10                  15      


Val Asp Asn Ile Pro Leu Ser Arg Pro Lys Arg Asn Leu Ser Arg Asp 
            20                  25                  30          


Phe Ser Asp Gly Val Leu Val Ala Glu Val Ile Lys Phe Tyr Phe Pro 
        35                  40                  45              


Lys Met Val Glu Met His Asn Tyr Val Pro Ala Asn Ser Leu Gln Gln 
    50                  55                  60                  


Lys Leu Ser Asn Trp Gly His Leu Asn Arg Lys Val Leu Lys Arg Leu 
65                  70                  75                  80  


Asn Phe Ser Val Pro Asp Asp Val Met Arg Lys Ile Ala Gln Cys Ala 
                85                  90                  95      


Pro Gly Val Val Glu Leu Val Leu Ile Pro Leu Arg Gln Arg Leu Glu 
            100                 105                 110         


Glu Arg Gln Arg Arg Arg Lys Gln Gly Ala Gly Ser Leu Gln Glu Leu 
        115                 120                 125             


Ala Pro Gln Asp Gly Ser Gly Tyr Met Asp Val Gly Lys Val Ala Phe 
    130                 135                 140                 


Ser Ile Ser Pro Ser Arg Leu Glu Leu Ser Phe Cys Pro Ser Ser Cys 
145                 150                 155                 160 


His Leu 
        


<210>  57
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Thr Glu Leu Glu Tyr Glu Ser Val Leu Cys Val Lys Pro Asp 
1               5                   10                  15      


Val Ser Val Tyr Arg Ile Pro Pro Arg Ala Ser Asn Arg Gly Tyr Arg 
            20                  25                  30          


Ala Ser Asp Trp Lys Leu Asp Gln Pro Asp Trp Thr Gly Arg Leu Arg 
        35                  40                  45              


Ile Thr Ser Lys Gly Lys Thr Ala Tyr Ile Lys Leu Glu Asp Lys Val 
    50                  55                  60                  


Ser Gly Glu Leu Phe Ala Gln Ala Pro Val Glu Gln Tyr Pro Gly Ile 
65                  70                  75                  80  


Ala Val Glu Thr Val Thr Asp Ser Ser Arg Tyr Phe Val Ile Arg Ile 
                85                  90                  95      


Gln Asp Gly Thr Gly Arg Ser Ala Phe Ile Gly Ile Gly Phe Thr Asp 
            100                 105                 110         


Arg Gly Asp Ala Phe Asp Phe Asn Val Ser Leu Gln Asp His Phe Lys 
        115                 120                 125             


Trp Val Lys Gln Glu Ser Glu Ile Ser Lys Glu Ser Gln Glu Met Asp 
    130                 135                 140                 


Ala Arg Pro Lys Leu Asp Leu Gly Phe Lys Glu Gly Gln Thr Ile Lys 
145                 150                 155                 160 


Leu Cys Ile Gly Asn Ile Thr Asn Lys Lys Gly Gly Ala Ser Lys Pro 
                165                 170                 175     


Arg Thr Ala Arg Gly Gly Gly Leu Ser Leu Leu Pro Pro Pro Pro Gly 
            180                 185                 190         


Gly Lys Val Thr Ile Pro Pro Pro Ser Ser Ser Val Ala Ile Ser Asn 
        195                 200                 205             


His Val Thr Pro Pro Pro Ile Pro Lys Ser Asn His Gly Gly Ser Asp 
    210                 215                 220                 


Ala Asp Ile Leu Leu Asp Leu Asp Ser Pro Ala Pro Val Thr Thr Pro 
225                 230                 235                 240 


Ala Pro Thr Pro Val Ser Val Ser Asn Asp Leu Trp Gly Asp Phe Ser 
                245                 250                 255     


Thr Ala Ser Ser Ser Val Pro Asn Gln Ala Pro Gln Pro Ser Asn Trp 
            260                 265                 270         


Val Gln Phe 
        275 


<210>  58
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Arg Gly Gln Gln Lys Ile Gln Ser Gln Gln Lys Asn Ala Lys 
1               5                   10                  15      


Lys Gln Ala Gly Gln Lys Lys Lys Gln Gly His Asp Gln Lys Ala Ala 
            20                  25                  30          


Ala Lys Ala Ala Leu Ile Tyr Thr Cys Thr Val Cys Arg Thr Gln Met 
        35                  40                  45              


Pro Asp Pro Lys Thr Phe Lys Gln His Phe Glu Ser Lys His Pro Lys 
    50                  55                  60                  


Thr Pro Leu Pro Pro Glu Leu Ala Asp Val Gln Ala 
65                  70                  75      


<210>  59
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Pro Val Val Arg Lys Ile Phe Arg Arg Arg Arg Gly Asp Ser Glu 
1               5                   10                  15      


Ser Glu Glu Asp Glu Gln Asp Ser Glu Glu Val Arg Leu Lys Leu Glu 
            20                  25                  30          


Glu Thr Arg Glu Val Gln Asn Leu Arg Lys Arg Pro Asn Gly Val Ser 
        35                  40                  45              


Ala Val Ala Leu Leu Val Gly Glu Lys Val Gln Glu Glu Thr Thr Leu 
    50                  55                  60                  


Val Asp Asp Pro Phe Gln Met Lys Thr Gly Gly Met Val Asp Met Lys 
65                  70                  75                  80  


Lys Leu Lys Glu Arg Gly Lys Asp Lys Ile Ser Glu Glu Glu Asp Leu 
                85                  90                  95      


His Leu Gly Thr Ser Phe Ser Ala Glu Thr Asn Arg Arg Asp Glu Asp 
            100                 105                 110         


Ala Asp Met Met Lys Tyr Ile Glu Thr Glu Leu Lys Lys Arg Lys Gly 
        115                 120                 125             


Ile Val Glu His Glu Glu Gln Lys Val Lys Pro Lys Asn Ala Glu Asp 
    130                 135                 140                 


Cys Leu Tyr Glu Leu Pro Glu Asn Ile Arg Val Ser Ser Ala Lys Lys 
145                 150                 155                 160 


Thr Glu Glu Met Leu Ser Asn Gln Met Leu Ser Gly Ile Pro Glu Val 
                165                 170                 175     


Asp Leu Gly Ile Asp Ala Lys Ile Lys Asn Ile Ile Ser Thr Glu Asp 
            180                 185                 190         


Ala Lys Ala Arg Leu Leu Ala Glu Gln Gln Asn Lys Lys Lys Asp Ser 
        195                 200                 205             


Glu Thr Ser Phe Val Pro Thr Asn Met Ala Val Asn Tyr Val Gln His 
    210                 215                 220                 


Asn Arg Phe Tyr His Glu Glu Leu Asn Ala Pro Ile Arg Arg Asn Lys 
225                 230                 235                 240 


Glu Glu Pro Lys Ala Arg Pro Leu Arg Val Gly Asp Thr Glu Lys Pro 
                245                 250                 255     


Glu Pro Glu Arg Ser Pro Pro Asn Arg Lys Arg Pro Ala Asn Glu Lys 
            260                 265                 270         


Ala Thr Asp Asp Tyr His Tyr Glu Lys Phe Lys Lys Met Asn Arg Arg 
        275                 280                 285             


Tyr 
    


<210>  60
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Pro Tyr Val Phe Ser Phe Lys Met Pro Gln Glu Gln Gly Gln Met 
1               5                   10                  15      


Phe Gln Tyr Tyr Pro Val Tyr Met Val Leu Pro Trp Glu Gln Pro Gln 
            20                  25                  30          


Gln Thr Val Pro Arg Ser Pro Gln Gln Thr Arg Gln Gln Gln Tyr Glu 
        35                  40                  45              


Glu Gln Ile Pro Phe Tyr Ala Gln Phe Gly Tyr Ile Pro Gln Leu Ala 
    50                  55                  60                  


Glu Pro Ala Ile Ser Gly Gly Gln Gln Gln Leu Ala Phe Asp Pro Gln 
65                  70                  75                  80  


Leu Gly Thr Ala Pro Glu Ile Ala Val Met Ser Thr Gly Glu Glu Ile 
                85                  90                  95      


Pro Tyr Leu Gln Lys Glu Ala Ile Asn Phe Arg His Asp Ser Ala Gly 
            100                 105                 110         


Val Phe Met Pro Ser Thr Ser Pro Lys Pro Ser Thr Thr Asn Val Phe 
        115                 120                 125             


Thr Ser Ala Val Asp Gln Thr Ile Thr Pro Glu Leu Pro Glu Glu Lys 
    130                 135                 140                 


Asp Lys Thr Asp Ser Leu Arg Glu Pro 
145                 150             


<210>  61
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Thr Ser Leu Phe Arg Arg Ser Ser Ser Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Thr Ala Gly Ala Arg Gly Gly Gly Gly Gly Thr Ala Ala Pro Gln Glu 
            20                  25                  30          


Leu Asn Asn Ser Arg Pro Ala Arg Gln Val Arg Arg Leu Glu Phe Asn 
        35                  40                  45              


Gln Ala Met Asp Asp Phe Lys Thr Met Phe Pro Asn Met Asp Tyr Asp 
    50                  55                  60                  


Ile Ile Glu Cys Val Leu Arg Ala Asn Ser Gly Ala Val Asp Ala Thr 
65                  70                  75                  80  


Ile Asp Gln Leu Leu Gln Met Asn Leu Glu Gly Gly Gly Ser Ser Gly 
                85                  90                  95      


Gly Val Tyr Glu Asp Ser Ser Asp Ser Glu Asp Ser Ile Pro Pro Glu 
            100                 105                 110         


Ile Leu Glu Arg Thr Leu Glu Pro Asp Ser Ser Asp Glu Glu Pro Pro 
        115                 120                 125             


Pro Val Tyr Ser Pro Pro Ala Tyr His Met His Val Phe Asp Arg Pro 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Pro Thr Pro Pro Pro Arg Ile Asp Ala Leu Gly 
145                 150                 155                 160 


Ser Gly Ala Pro Thr Ser Gln Arg Arg Tyr Arg Asn Trp Asn Pro Pro 
                165                 170                 175     


Leu Leu Gly Asn Leu Pro Asp Asp Phe Leu Arg Ile Leu Pro Gln Gln 
            180                 185                 190         


Leu Asp Ser Ile Gln Gly Asn Ala Gly Gly Pro Lys Pro Gly Ser Gly 
        195                 200                 205             


Glu Gly Cys Pro Pro Ala Met Ala Gly Pro Gly Pro Gly Asp Gln Glu 
    210                 215                 220                 


Ser Arg Trp Lys Gln Tyr Leu Glu Asp Glu Arg Ile Ala Leu Phe Leu 
225                 230                 235                 240 


Gln Asn Glu Glu Phe Met Lys Glu Leu Gln Arg Asn Arg Asp Phe Leu 
                245                 250                 255     


Leu Ala Leu Glu Arg Asp Arg Leu Lys Tyr Glu Ser Gln Lys Ser Lys 
            260                 265                 270         


Ser Ser Ser Val Ala Val Gly Asn Asp Phe Gly Phe Ser Ser Pro Val 
        275                 280                 285             


Pro Gly Thr Gly Asp Ala Asn Pro Ala Val Ser Glu Asp Ala Leu Phe 
    290                 295                 300                 


Arg Asp Lys Leu Lys His Met Gly Lys Ser Thr Arg Arg Lys Leu Phe 
305                 310                 315                 320 


Glu Leu Ala Arg Ala Phe Ser Glu Lys Thr Lys Met Arg Lys Ser Lys 
                325                 330                 335     


Arg Lys His Leu Leu Lys His Gln Ser Leu Gly Ala Ala Ala Ser Thr 
            340                 345                 350         


Ala Asn Leu Leu Asp Asp Val Glu Gly His Ala Cys Asp Glu Asp Phe 
        355                 360                 365             


Arg Gly Arg Arg Gln Glu Ala Pro Lys Val Glu Glu Gly Leu Arg Glu 
    370                 375                 380                 


Gly Gln 
385     


<210>  62
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Ala Gln Tyr Gly Ser Met Ser Phe Asn Pro Ser Thr Pro Gly 
1               5                   10                  15      


Ala Ser Tyr Gly Pro Gly Arg Gln Glu Pro Arg Asn Ser Gln Leu Arg 
            20                  25                  30          


Ile Val Leu Val Gly Lys Thr Gly Ala Gly Lys Ser Ala Thr Gly Asn 
        35                  40                  45              


Ser Ile Leu Gly Arg Lys Val Phe His Ser Gly Thr Ala Ala Lys Ser 
    50                  55                  60                  


Ile Thr Lys Lys Cys Glu Lys Arg Ser Ser Ser Trp Lys Glu Thr Glu 
65                  70                  75                  80  


Leu Val Val Val Asp Thr Pro Gly Ile Phe Asp Thr Glu Val Pro Asn 
                85                  90                  95      


Ala Glu Thr Ser Lys Glu Ile Ile Arg Cys Ile Leu Leu Thr Ser Pro 
            100                 105                 110         


Gly Pro His Ala Leu Leu Leu Val Val Pro Leu Gly Arg Tyr Thr Glu 
        115                 120                 125             


Glu Glu His Lys Ala Thr Glu Lys Ile Leu Lys Met Phe Gly Glu Arg 
    130                 135                 140                 


Ala Arg Ser Phe Met Ile Leu Ile Phe Thr Arg Lys Asp Asp Leu Gly 
145                 150                 155                 160 


Asp Thr Asn Leu His Asp Tyr Leu Arg Glu Ala Pro Glu Asp Ile Gln 
                165                 170                 175     


Asp Leu Met Asp Ile Phe Gly Asp Arg Tyr Cys Ala Leu Asn Asn Lys 
            180                 185                 190         


Ala Thr Gly Ala Glu Gln Glu Ala Gln Arg Ala Gln Leu Leu Gly Leu 
        195                 200                 205             


Ile Gln Arg Val Val Arg Glu Asn Lys Glu Gly Cys Tyr Thr Asn Arg 
    210                 215                 220                 


Met Tyr Gln Arg Ala Glu Glu Glu Ile Gln Lys Gln Thr Gln Ala Met 
225                 230                 235                 240 


Gln Glu Leu His Arg Val Glu Leu Glu Arg Glu Lys Ala Arg Ile Arg 
                245                 250                 255     


Glu Glu Tyr Glu Glu Lys Ile Arg Lys Leu Glu Asp Lys Val Glu Gln 
            260                 265                 270         


Glu Lys Arg Lys Lys Gln Met Glu Lys Lys Leu Ala Glu Gln Glu Ala 
        275                 280                 285             


His Tyr Ala Val Arg Gln Gln Arg Ala Arg Thr Glu Val Glu Ser Lys 
    290                 295                 300                 


Asp Gly Ile Leu Glu Leu Ile Met Thr Ala Leu Gln Ile Ala Ser Phe 
305                 310                 315                 320 


Ile Leu Leu Arg Leu Phe Ala Glu Asp 
                325                 


<210>  63
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ser Glu Val Leu Pro Tyr Gly Asp Glu Lys Leu Ser Pro Tyr Gly 
1               5                   10                  15      


Asp Gly Gly Asp Val Gly Gln Ile Phe Ser Cys Arg Leu Gln Asp Thr 
            20                  25                  30          


Asn Asn Phe Phe Gly Ala Gly Gln Asn Lys Arg Pro Pro Lys Leu Gly 
        35                  40                  45              


Gln Ile Gly Arg Ser Lys Arg Val Val Ile Glu Asp Asp Arg Ile Asp 
    50                  55                  60                  


Asp Val Leu Lys Asn Met Thr Asp Lys Ala Pro Pro Gly Val 
65                  70                  75              


<210>  64
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Lys Ile Val Ile Arg Gly Asp Arg Asn Thr Gly Lys Thr Ala Leu 
1               5                   10                  15      


Trp His Arg Leu Gln Gly Arg Pro Phe Val Glu Glu Tyr Ile Pro Thr 
            20                  25                  30          


Gln Glu Ile Gln Val Thr Ser Ile His Trp Ser Tyr Lys Thr Thr Asp 
        35                  40                  45              


Asp Ile Val Lys Val Glu Val Trp Asp Val Val Asp Lys Gly Lys Cys 
    50                  55                  60                  


Lys Lys Arg Gly Asp Gly Leu Lys Met Glu Asn Asp Pro Gln Glu Ala 
65                  70                  75                  80  


Glu Ser Glu Met Ala Leu Asp Ala Glu Phe Leu Asp Val Tyr Lys Asn 
                85                  90                  95      


Cys Asn Gly Val Val Met Met Phe Asp Ile Thr Lys Gln Trp Thr Phe 
            100                 105                 110         


Asn Tyr Ile Leu Arg Glu Leu Pro Lys Val Pro Thr His Val Pro Val 
        115                 120                 125             


Cys Val Leu Gly Asn Tyr Arg Asp Met Gly Glu His Arg Val Ile Leu 
    130                 135                 140                 


Pro Asp Asp Val Arg Asp Phe Ile Asp Asn Leu Asp Arg Pro Pro Gly 
145                 150                 155                 160 


Ser Ser Tyr Phe Arg Tyr Ala Glu Ser Ser Met Lys Asn Ser Phe Gly 
                165                 170                 175     


Leu Lys Tyr Leu His Lys Phe Phe Asn Ile Pro Phe Leu Gln Leu Gln 
            180                 185                 190         


Arg Glu Thr Leu Leu Arg Gln Leu Glu Thr Asn Gln Leu Asp Met Asp 
        195                 200                 205             


Ala Thr Leu Glu Glu Leu Ser Val Gln Gln Glu Thr Glu Asp Gln Asn 
    210                 215                 220                 


Tyr Gly Ile Phe Leu Glu Met Met Glu Ala Arg Ser Arg Gly His Ala 
225                 230                 235                 240 


Ser Pro Leu Ala Ala Asn Gly Gln Ser Pro Ser Pro Gly Ser Gln Ser 
                245                 250                 255     


Pro Val Val Pro Ala Gly Ala Val Ser Thr Gly Ser Ser Ser Pro Gly 
            260                 265                 270         


Thr Pro Gln Pro Ala Pro Gln Leu Pro Leu Asn Ala Ala Pro Pro Ser 
        275                 280                 285             


Ser Val Pro Pro Val Pro Pro Ser Glu Ala Leu Pro Pro Pro Ala Cys 
    290                 295                 300                 


Pro Ser Ala Pro Ala Pro Arg Arg Ser Ile Ile Ser Arg Leu Phe Gly 
305                 310                 315                 320 


Thr Ser Pro Ala Thr Glu Ala Ala Pro Pro Pro Pro Glu Pro Val Pro 
                325                 330                 335     


Ala Ala Glu Gly Pro Ala Thr Val Gln Ser Val Glu Asp Phe Val Pro 
            340                 345                 350         


Asp Asp Arg Leu Asp Arg Ser Phe Leu Glu Asp Thr Thr Pro Ala Arg 
        355                 360                 365             


Asp Glu Lys Lys Val Gly Ala Lys Ala Ala Gln Gln Asp Ser Asp Ser 
    370                 375                 380                 


Asp Gly Glu Ala Leu Gly Gly Asn Pro Met Val Ala Gly Phe Gln Asp 
385                 390                 395                 400 


Asp Val Asp Leu Glu Asp Gln Pro Arg Gly Ser Pro Pro Leu Pro Ala 
                405                 410                 415     


Gly Pro Val Pro Ser Gln Asp Ile Thr Leu Ser Ser Glu Glu Glu Ala 
            420                 425                 430         


Glu Val Ala Ala Pro Thr Lys Gly Pro Ala Pro Ala Pro Gln Gln Cys 
        435                 440                 445             


Ser Glu Pro Glu Thr Lys Trp Ser Ser Ile Pro Ala Ser Lys Pro Arg 
    450                 455                 460                 


Arg Gly Thr Ala Pro Thr Arg Thr Ala Ala Pro Pro Trp Pro Gly Gly 
465                 470                 475                 480 


Val Ser Val Arg Thr Gly Pro Glu Lys Arg Ser Ser Thr Arg Pro Pro 
                485                 490                 495     


Ala Glu Met Glu Pro Gly Lys Gly Glu Gln Ala Ser Ser Ser Glu Ser 
            500                 505                 510         


Asp Pro Glu Gly Pro Ile Ala Ala Gln Met Leu Ser Phe Val Met Asp 
        515                 520                 525             


Asp Pro Asp Phe Glu Ser Glu Gly Ser Asp Thr Gln Arg Arg Ala Asp 
    530                 535                 540                 


Asp Phe Pro Val Arg Asp Asp Pro Ser Asp Val Thr Asp Glu Asp Glu 
545                 550                 555                 560 


Gly Pro Ala Glu Pro Pro Pro Pro Pro Lys Leu Pro Leu Pro Ala Phe 
                565                 570                 575     


Arg Leu Lys Asn Asp Ser Asp Leu Phe Gly Leu Gly Leu Glu Glu Ala 
            580                 585                 590         


Gly Pro Lys Glu Ser Ser Glu Glu Gly Lys Glu Gly Lys Thr Pro Ser 
        595                 600                 605             


Lys Glu Lys Lys Lys Lys Lys Lys Lys Gly Lys Glu Glu Glu Glu Lys 
    610                 615                 620                 


Ala Ala Lys Lys Lys Ser Lys His Lys Lys Ser Lys Asp Lys Glu Glu 
625                 630                 635                 640 


Gly Lys Glu Glu Arg Arg Arg Arg Gln Gln Arg Pro Pro Arg Ser Arg 
                645                 650                 655     


Glu Arg Thr Ala Ala Asp Glu Leu Glu Ala Phe Leu Gly Gly Gly Ala 
            660                 665                 670         


Pro Gly Gly Arg His Pro Gly Gly Gly Asp Tyr Glu Glu Leu 
        675                 680                 685     


<210>  65
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ser Asp Glu Val Phe Ser Thr Thr Leu Ala Tyr Thr Lys Ser Pro 
1               5                   10                  15      


Lys Val Thr Lys Arg Thr Thr Phe Gln Asp Glu Leu Ile Arg Ala Ile 
            20                  25                  30          


Thr Ala Arg Ser Ala Arg Gln Arg Ser Ser Glu Tyr Ser Asp Asp Phe 
        35                  40                  45              


Asp Ser Asp Glu Ile Val Ser Leu Gly Asp Phe Ser Asp Thr Ser Ala 
    50                  55                  60                  


Asp Glu Asn Ser Val Asn Lys Lys Met Asn Asp Phe His Ile Ser Asp 
65                  70                  75                  80  


Asp Glu Glu Lys Asn Pro Ser Lys Leu Leu Phe Leu Lys Thr Asn Lys 
                85                  90                  95      


Ser Asn Gly Asn Ile Thr Lys Asp Glu Pro Val Cys Ala Ile Lys Asn 
            100                 105                 110         


Glu Glu Glu Met Ala Pro Asp Gly Cys Glu Asp Ile Val Val Lys Ser 
        115                 120                 125             


Phe Ser Glu Ser Gln Asn Lys Asp Glu Glu Phe Glu Lys Asp Lys Ile 
    130                 135                 140                 


Lys Met Lys Pro Lys Pro Arg Ile Leu Ser Ile Lys Ser Thr Ser Ser 
145                 150                 155                 160 


Ala Glu Asn Asn Ser Leu Asp Thr Asp Asp His Phe Lys Pro Ser Pro 
                165                 170                 175     


Trp Pro Arg Ser Met Leu Lys Lys Lys Ser His Met Glu Glu Lys Asp 
            180                 185                 190         


Gly Leu Glu Asp Lys Glu Thr Ala Leu Ser Glu Glu Leu Glu Leu His 
        195                 200                 205             


Ser Ala Pro Ser Ser Leu Pro Thr Pro Asn Gly Ile Gln Leu Glu Ala 
    210                 215                 220                 


Glu Lys Lys Ala Phe Ser Glu Asn Leu Asp Pro Glu Asp Ser Cys Leu 
225                 230                 235                 240 


Thr Ser Leu Ala Ser Ser Ser Leu Lys Gln Ile Leu Gly Asp Ser Phe 
                245                 250                 255     


Ser Pro Gly Ser Glu Gly Asn Ala Ser Gly Lys Asp Pro Asn Glu Glu 
            260                 265                 270         


Ile Thr Glu Asn His Asn Ser Leu Lys Ser Asp Glu Asn Lys Glu Asn 
        275                 280                 285             


Ser Phe Ser Ala Asp His Val Thr Thr Ala Val Glu Lys Ser Lys Glu 
    290                 295                 300                 


Ser Gln Val Thr Ala Asp Asp Leu Glu Glu Glu Lys Ala Lys Ala Glu 
305                 310                 315                 320 


Leu Ile Met Asp Asp Asp Arg Thr Val Asp Pro Leu Leu Ser Lys Ser 
                325                 330                 335     


Gln Ser Ile Leu Ile Ser Thr Ser Ala Thr Ala Ser Ser Lys Lys Thr 
            340                 345                 350         


Ile Glu Asp Arg Asn Ile Lys Asn Lys Lys Ser Thr Asn Asn Arg Ala 
        355                 360                 365             


Ser Ser Ala Ser Ala Arg Ser Gly 
    370                 375     


<210>  66
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Lys Lys Phe Phe Gln Glu Phe Lys Ala Asp Ile Lys Phe Lys Ser 
1               5                   10                  15      


Ala Gly Pro Gly Gln Lys Leu Lys Glu Ser Val Gly Glu Lys Ala His 
            20                  25                  30          


Lys Glu Lys Pro Asn Gln Pro Ala Pro Arg Pro Pro Arg Gln Gly Pro 
        35                  40                  45              


Thr Asn Glu Ala Gln Met Ala Ala Ala Ala Ala Leu Ala Arg Leu Glu 
    50                  55                  60                  


Gln Lys Gln Ser Arg Ala Trp Gly Pro Thr Ser Gln Asp Thr Ile Arg 
65                  70                  75                  80  


Asn Gln Val Arg Lys Glu Leu Gln Ala Glu Ala Thr Val Ser Gly Ser 
                85                  90                  95      


Pro Glu Ala Pro Gly Thr Asn Val Val Ser Glu Pro Arg Glu Glu Gly 
            100                 105                 110         


Ser Ala His Leu Ala Val Pro Gly Val Tyr Phe Thr Cys Pro Leu Thr 
        115                 120                 125             


Gly Ala Thr Leu Arg Lys Asp Gln Arg Asp Ala Cys Ile Lys Glu Ala 
    130                 135                 140                 


Ile Leu Leu His Phe Ser Thr Asp Pro Val Ala Ala Ser Ile Met Lys 
145                 150                 155                 160 


Ile Tyr Thr Phe Asn Lys Asp Gln Asp Arg Val Lys Leu Gly Val Asp 
                165                 170                 175     


Thr Ile Ala Lys Tyr Leu Asp Asn Ile His Leu His Pro Glu Glu Glu 
            180                 185                 190         


Lys Tyr Arg Lys Ile Lys Leu Gln Asn Lys Val Phe Gln Glu Arg Ile 
        195                 200                 205             


Asn Cys Leu Glu Gly Thr His Glu Phe Phe Glu Ala Ile Gly Phe Gln 
    210                 215                 220                 


Lys Val Leu Leu Pro Ala Gln Asp Gln Glu Asp Pro Glu Glu Phe Tyr 
225                 230                 235                 240 


Val Leu Ser Glu Thr Thr Leu Ala Gln Pro Gln Ser Leu Glu Arg His 
                245                 250                 255     


Lys Glu Gln Leu Leu Ala Ala Glu Pro Val Arg Ala Lys Leu Asp Arg 
            260                 265                 270         


Gln Arg Arg Val Phe Gln Pro Ser Pro Leu Ala Ser Gln Phe Glu Leu 
        275                 280                 285             


Pro Gly Asp Phe Phe Asn Leu Thr Ala Glu Glu Ile Lys Arg Glu Gln 
    290                 295                 300                 


Arg Leu Arg Ser Glu Ala Val Glu Arg Leu Ser Val Leu Arg Thr Lys 
305                 310                 315                 320 


Ala Met Arg Glu Lys Glu Glu Gln Arg Gly Leu Arg Lys Tyr Asn Tyr 
                325                 330                 335     


Thr Leu Leu Arg Val Arg Leu Pro Asp Gly Cys Leu Leu Gln Gly Thr 
            340                 345                 350         


Phe Tyr Ala Arg Glu Arg Leu Gly Ala Val Tyr Gly Phe Val Arg Glu 
        355                 360                 365             


Ala Leu Gln Ser Asp Trp Leu Pro Phe Glu Leu Leu Ala Ser Gly Gly 
    370                 375                 380                 


Gln Lys Leu Ser Glu Asp Glu Asn Leu Ala Leu Asn Glu Cys Gly Leu 
385                 390                 395                 400 


Val Pro Ser Ala Leu Leu Thr Phe Ser Trp Asp Met Ala Val Leu Glu 
                405                 410                 415     


Asp Ile Lys Ala Ala Gly Ala Glu Pro Asp Ser Ile Leu Lys Pro Glu 
            420                 425                 430         


Leu Leu Ser Ala Ile Glu Lys Leu Leu 
        435                 440     


<210>  67
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Glu Ala Ala Gly Ser Pro Ala Ala Thr Glu Thr Gly Lys Tyr Ile 
1               5                   10                  15      


Ala Ser Thr Gln Arg Pro Asp Gly Thr Trp Arg Lys Gln Arg Arg Val 
            20                  25                  30          


Lys Glu Gly Tyr Val Pro Gln Glu Glu Val Pro Val Tyr Glu Asn Lys 
        35                  40                  45              


Tyr Val Lys Phe Phe Lys Ser Lys Pro Glu Leu Pro Pro Gly Leu Ser 
    50                  55                  60                  


Pro Glu Ala Thr Ala Pro Val Thr Pro Ser Arg Pro Glu Gly Gly Glu 
65                  70                  75                  80  


Pro Gly Leu Ser Lys Thr Ala Lys Arg Asn Leu Lys Arg Lys Glu Lys 
                85                  90                  95      


Arg Arg Gln Gln Gln Glu Lys Gly Glu Ala Glu Ala Leu Ser Arg Thr 
            100                 105                 110         


Leu Asp Lys Val Ser Leu Glu Glu Thr Ala Gln Leu Pro Ser Ala Pro 
        115                 120                 125             


Gln Gly Ser Arg Ala Ala Pro Thr Ala Ala Ser Asp Gln Pro Asp Ser 
    130                 135                 140                 


Ala Ala Thr Thr Glu Lys Ala Lys Lys Ile Lys Asn Leu Lys Lys Lys 
145                 150                 155                 160 


Leu Arg Gln Val Glu Glu Leu Gln Gln Arg Ile Gln Ala Gly Glu Val 
                165                 170                 175     


Ser Gln Pro Ser Lys Glu Gln Leu Glu Lys Leu Ala Arg Arg Arg Ala 
            180                 185                 190         


Leu Glu Glu Glu Leu Glu Asp Leu Glu Leu Gly Leu 
        195                 200                 


<210>  68
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Ser Arg Gly Lys Thr Glu Thr Ser Lys Leu Lys Gln Asn Leu 
1               5                   10                  15      


Glu Glu Gln Leu Asp Arg Leu Met Gln Gln Leu Gln Asp Leu Glu Glu 
            20                  25                  30          


Cys Arg Glu Glu Leu Asp Thr Asp Glu Tyr Glu Glu Thr Lys Lys Glu 
        35                  40                  45              


Thr Leu Glu Gln Leu Ser Glu Phe Asn Asp Ser Leu Lys Lys Ile Met 
    50                  55                  60                  


Ser Gly Asn Met Thr Leu Val Asp Glu Leu Ser Gly Met Gln Leu Ala 
65                  70                  75                  80  


Ile Gln Ala Ala Ile Ser Gln Ala Phe Lys Thr Pro Glu Val Ile Arg 
                85                  90                  95      


Leu Phe Ala Lys Lys Gln Pro Gly Gln Leu Arg Thr Arg Leu Ala Glu 
            100                 105                 110         


Met Asp Arg Asp Leu Met Val Gly Lys Leu Glu Arg Asp Leu Tyr Thr 
        115                 120                 125             


Gln Gln Lys Val Glu Ile Leu Thr Ala Leu Arg Lys Leu Gly Glu Lys 
    130                 135                 140                 


Leu Thr Ala Asp Asp Glu Ala Phe Leu Ser Ala Asn Ala Gly Ala Ile 
145                 150                 155                 160 


Leu Ser Gln Phe Glu Lys Val Ser Thr Asp Leu Gly Ser Gly Asp Lys 
                165                 170                 175     


Ile Leu Ala Leu Ala Ser Phe Glu Val Glu Lys Thr Lys Lys 
            180                 185                 190 


<210>  69
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Pro Lys Lys Asp Val Lys Lys Pro Val Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Lys 
            20                  25                  30          


Pro Lys Glu Glu Lys Ile Asp Leu Ser Ala Ile Lys Ile Glu Phe Ser 
        35                  40                  45              


Lys Glu Gln Gln Asp Glu Phe Lys Glu Ala Phe Leu Leu Phe Asp Arg 
    50                  55                  60                  


Thr Gly Asp Ser Lys Ile Thr Leu Ser Gln Val Gly Asp Val Leu Arg 
65                  70                  75                  80  


Ala Leu Gly Thr Asn Pro Thr Asn Ala Glu Val Arg Lys Val Leu Gly 
                85                  90                  95      


Asn Pro Ser Asn Glu Glu Leu Asn Ala Lys Lys Ile Glu Phe Glu Gln 
            100                 105                 110         


Phe Leu Pro Met Met Gln Ala Ile Ser Asn Asn Lys Asp Gln Ala Thr 
        115                 120                 125             


Tyr Glu Asp Phe Val Glu Gly Leu Arg Val Phe Asp Lys Glu Gly Asn 
    130                 135                 140                 


Gly Thr Val Met Gly Ala Glu Leu Arg His Val Leu Ala Thr Leu Gly 
145                 150                 155                 160 


Glu Lys Met Lys Glu Glu Glu Val Glu Ala Leu Met Ala Gly Gln Glu 
                165                 170                 175     


Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val Lys His Ile Met 
            180                 185                 190         


Ser Ile 
        


<210>  70
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Glu Lys Leu Phe Asn Glu Asn Glu Gly Met Pro Ser Asn Gln Gly 
1               5                   10                  15      


Lys Ile Asp Asn Glu Glu Gln Pro Pro His Glu Gly Lys Pro Glu Val 
            20                  25                  30          


Ala Cys Ile Leu Glu Asp Lys Lys Leu Glu Asn Glu Gly Asn Thr Glu 
        35                  40                  45              


Asn Thr Gly Lys Arg Val Glu Glu Pro Leu Lys Asp Lys Glu Lys Pro 
    50                  55                  60                  


Glu Ser Ala Gly Lys Ala Lys Gly Glu Gly Lys Ser Glu Arg Lys Gly 
65                  70                  75                  80  


Lys Ser Glu Met Gln Gly Gly Ser Lys Thr Glu Gly Lys Pro Glu Arg 
                85                  90                  95      


Gly Gly Arg Ala Glu Gly Glu Gly Glu Pro Asp Ser Glu Arg Glu Pro 
            100                 105                 110         


Glu Ser Glu Gly Glu Pro Glu Ser Glu Thr Arg Ala Ala Gly Lys Arg 
        115                 120                 125             


Pro Ala Glu Asp Asp Ile Pro Arg Lys Ala Lys Arg Lys Thr Asn Lys 
    130                 135                 140                 


Gly Leu Ala Gln Tyr Leu Lys Gln Tyr Lys Glu Ala Ile His Asp Met 
145                 150                 155                 160 


Asn Phe Ser Asn Glu Asp Met Ile Arg Glu Phe Asp Asn Met Ala Arg 
                165                 170                 175     


Val Glu Asp Lys Arg Arg Lys Ser Lys Gln Lys Leu Gly Ala Phe Leu 
            180                 185                 190         


Trp Met Gln Arg Asn Leu Gln Asp Pro Phe Tyr Pro Arg Gly Pro Arg 
        195                 200                 205             


Glu Phe Arg Gly Gly Cys Arg Ala Pro Arg Arg Asp Thr Glu Asp Ile 
    210                 215                 220                 


Pro Tyr Val 
225         


<210>  71
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Thr Ser Leu Gln Thr Glu Pro Gln Asp Arg Ser Pro Ala Pro Met 
        35                  40                  45              


Ser Cys Asp Lys Ser Thr Gln Thr Pro Ser Pro Pro Cys Gln Ala Phe 
    50                  55                  60                  


Asn His Tyr Leu Ser Ala Met Ala Ser Met Arg Gln Ala Glu Pro Ala 
65                  70                  75                  80  


Asp Met Arg Pro Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly 
                85                  90                  95      


Asp Glu Phe Asn Ala Tyr Tyr Ala Arg Arg Leu Glu Lys 
            100                 105                 


<210>  72
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Val Ser Val Ser Gln Gln Pro 
        35                  40                  45              


Val Ser Ala Pro Val Pro Ile Ala Ala His Ala Ser Val Ala Gly His 
    50                  55                  60                  


Leu Ser Thr Ser Thr Thr Val Ser Ser Ser Gly Ala Gln Asn Ser Asp 
65                  70                  75                  80  


Ser Thr Lys Lys Thr Leu Val Thr Leu Ile Ala Asn Asn Asn Ala Gly 
                85                  90                  95      


Asn Pro Leu Val Gln Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn 
            100                 105                 110         


Pro Ala Pro Gly Leu Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro 
        115                 120                 125             


Val Gln Val Met Gln Asn Ala Asn His Val Thr Ser Ser Pro Val Ala 
    130                 135                 140                 


Ser Gln Pro Ile Phe Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val 
145                 150                 155                 160 


Arg Pro Val Gln Asn Ala Met Asn Gln Val Gly Ile Val Leu Asn Val 
                165                 170                 175     


Gln Gln Gly Gln Thr Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly 
            180                 185                 190         


Thr Gln Phe Val Lys Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln 
        195                 200                 205             


Met Thr Pro Val Arg Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr 
    210                 215                 220                 


Asn Thr Phe Thr Thr Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr 
225                 230                 235                 240 


Val Pro Gln Ser Gln Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser 
                245                 250                 255     


Thr Thr Pro Thr Ala Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val 
            260                 265                 270         


Gln Ser Pro Gly Gln Ser Asn Gln Thr Thr Asn Pro Lys Leu Ala Pro 
        275                 280                 285             


Ser Phe Pro Ser Pro Pro Ala Val Ser Ile Ala Ser Phe Val Thr Val 
    290                 295                 300                 


Lys Arg Pro Gly Val Thr Gly Glu Asn Ser Asn Glu Val Ala Lys Leu 
305                 310                 315                 320 


Val Asn Thr Leu Asn Thr Ile Pro Ser Leu Gly Gln Ser Pro Gly Pro 
                325                 330                 335     


Val Val Val Ser Asn Asn Ser Ser Ala His Gly Ser Gln Arg Thr Ser 
            340                 345                 350         


Gly Pro Glu Ser Ser Met Lys Gly Thr Ile Thr 
        355                 360             


<210>  73
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Asp Ser Glu Asn Gln Gly Pro Ala Glu Pro Ser Gln Ala Ala 
1               5                   10                  15      


Ala Ala Ala Glu Ala Ala Ala Glu Glu Val Met Ala Glu Gly Gly Ala 
            20                  25                  30          


Gln Gly Gly Asp Cys Asp Ser Ala Ala Gly Asp Pro Asp Ser Ala Ala 
        35                  40                  45              


Gly Gln Met Ala Glu Glu Pro Gln Thr Pro Ala Glu Asn Ala Pro Lys 
    50                  55                  60                  


Pro Lys Asn Asp Phe Ile Glu Ser Leu Pro Asn Ser Val Lys Cys Arg 
65                  70                  75                  80  


Val Leu Ala Leu Lys Lys Leu Gln Lys Arg Cys Asp Lys Ile Glu Ala 
                85                  90                  95      


Lys Phe Asp Lys Glu Phe Gln Ala Leu Glu Lys Lys Tyr Asn Asp Ile 
            100                 105                 110         


Tyr Lys Pro Leu Leu Ala Lys Ile Gln Glu Leu Thr Gly Glu Met Glu 
        115                 120                 125             


Gly Cys Ala Trp Thr Leu Glu Gly Glu Glu Glu Glu Glu Glu Glu Tyr 
    130                 135                 140                 


Glu Asp Asp Glu Glu Glu Gly Glu Asp Glu Glu Glu Glu Glu Ala Ala 
145                 150                 155                 160 


Ala Glu Ala Ala Ala Gly Ala Lys His Asp Asp Ala His Ala Glu Met 
                165                 170                 175     


Pro Asp Asp Ala Lys Lys 
            180         


<210>  74
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Asp Gly Pro Ala Glu Pro Gln Ile Pro Gly Leu Trp Asp Thr Tyr 
1               5                   10                  15      


Glu Asp Asp Ile Ser Glu Ile Ser Gln Lys Leu Pro Gly Glu Tyr Phe 
            20                  25                  30          


Arg Tyr Lys Gly Val Pro Phe Pro Val Gly Leu Tyr Ser Leu Glu Ser 
        35                  40                  45              


Ile Ser Leu Ala Glu Asn Thr Gln Asp Val Arg Asp Asp Asp Ile Phe 
    50                  55                  60                  


Ile Ile Thr Tyr Pro Lys Ser Gly Thr Thr Trp Met Ile Glu Ile Ile 
65                  70                  75                  80  


Cys Leu Ile Leu Lys Glu Gly Asp Pro Ser Trp Ile Arg Ser Val Pro 
                85                  90                  95      


Ile Trp Glu Arg Ala Pro Trp Cys Glu Thr Ile Val Gly Ala Phe Ser 
            100                 105                 110         


Leu Pro Asp Gln Tyr Ser Pro Arg Leu Met Ser Ser His Leu Pro Ile 
        115                 120                 125             


Gln Ile Phe Thr Lys Ala Phe Phe Ser Ser Lys Ala Lys Val Ile Tyr 
    130                 135                 140                 


Met Gly Arg Asn Pro Arg Asp Val Val Val Ser Leu Tyr His Tyr Ser 
145                 150                 155                 160 


Lys Ile Ala Gly Gln Leu Lys Asp Pro Gly Thr Pro Asp Gln Phe Leu 
                165                 170                 175     


Arg Asp Phe Leu Lys Gly Glu Val Gln Phe Gly Ser Trp Phe Asp His 
            180                 185                 190         


Ile Lys Gly Trp Leu Arg Met Lys Gly Lys Asp Asn Phe Leu Phe Ile 
        195                 200                 205             


Thr Tyr Glu Glu Leu Gln Gln Asp Leu Gln Gly Ser Val Glu Arg Ile 
    210                 215                 220                 


Cys Gly Phe Leu Gly Arg Pro Leu Gly Lys Glu Ala Leu Gly Ser Val 
225                 230                 235                 240 


Val Ala His Ser Thr Phe Ser Ala Met Lys Ala Asn Thr Met Ser Asn 
                245                 250                 255     


Tyr Thr Leu Leu Pro Pro Ser Leu Leu Asp His Arg Arg Gly Ala Phe 
            260                 265                 270         


Leu Arg Lys Gly Val Cys Gly Asp Trp Lys Asn His Phe Thr Val Ala 
        275                 280                 285             


Gln Ser Glu Ala Phe Asp Arg Ala Tyr Arg Lys Gln Met Arg Gly Met 
    290                 295                 300                 


Pro Thr Phe Pro Trp Asp Glu Asp Pro Glu Glu Asp Gly Ser Pro Asp 
305                 310                 315                 320 


Pro Glu Pro Ser Pro Glu Pro Glu Pro Lys Pro Ser Leu Glu Pro Asn 
                325                 330                 335     


Thr Ser Leu Glu Arg Glu Pro Arg Pro Asn Ser Ser Pro Ser Pro Ser 
            340                 345                 350         


Pro Gly Gln Ala Ser Glu Thr Pro His Pro Arg Pro Ser 
        355                 360                 365 


<210>  75
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  75

Met His Asp Glu Val Ala Gln Pro Leu Asn Leu Ser Ala Lys Pro Lys 
1               5                   10                  15      


Thr Ser Asp Gly Lys Ser Pro Thr Ser Pro Thr Ser Pro His Met Pro 
            20                  25                  30          


Ala Leu Arg Ile Asn Ser Gly Ala Gly Pro Leu Lys Ala Ser Val Pro 
        35                  40                  45              


Ala Ala Leu Ala Ser Pro Ser Ala Arg Val Ser Thr Ile Gly Tyr Leu 
    50                  55                  60                  


Asn Asp His Asp Ala Val Thr Lys Ala Ile Gln Glu Ala Arg Gln Met 
65                  70                  75                  80  


Lys Glu Gln Leu Arg Arg Glu Gln Gln Val Leu Asp Gly Lys Val Ala 
                85                  90                  95      


Val Val Asn Ser Leu Gly Leu Asn Asn Cys Arg Thr Glu Lys Glu Lys 
            100                 105                 110         


Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala Val Lys Gln Asn Glu 
        115                 120                 125             


Glu Gly Lys Phe Ser His Ala Met Met Asp Phe Asn Leu Ser Gly Asp 
    130                 135                 140                 


Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg Ile Tyr Arg Glu Ser 
145                 150                 155                 160 


Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys Arg Pro Met Asn Ala 
                165                 170                 175     


Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln Ala Phe 
            180                 185                 190         


Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser Arg Trp 
        195                 200                 205             


Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr Tyr Glu Glu Gln Ala 
    210                 215                 220                 


Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro Asp Tyr Lys Tyr Lys 
225                 230                 235                 240 


Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly Lys Lys Leu Arg Ile 
                245                 250                 255     


Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg Gln Glu Met Arg Gln 
            260                 265                 270         


Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro Ile Ala Thr Ala Gly 
        275                 280                 285             


Val Val Tyr Pro Gly Ala Ile Ala Met Ala Gly Met Pro Ser Pro His 
    290                 295                 300                 


Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser Pro Glu Pro Gly Met 
305                 310                 315                 320 


Pro Val Ile Gln Ser Thr Tyr Gly Val Lys Gly Glu Glu Pro His Ile 
                325                 330                 335     


Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly Glu Ile Tyr Asp Glu 
            340                 345                 350         


Tyr Asp Glu Glu Glu Asp Asp Pro Asp Val Asp Tyr Gly Ser Asp Ser 
        355                 360                 365             


Glu Asn His Ile Ala Gly Gln Ala Asn 
    370                 375         


<210>  76
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ser Lys Arg Lys Leu Ile Pro Lys Leu Ser Ile Gln Ser Pro Val 
1               5                   10                  15      


Leu His Thr Asn Leu Asn Val Gln Ser Thr His Pro Pro Leu Lys Lys 
            20                  25                  30          


Glu Asp Leu His Arg Ile Ser Lys Asp Ser Leu Glu Ser Asp Ser Glu 
        35                  40                  45              


Ser Leu Thr Gln Glu Ile Met Cys His Ser Glu Phe Asp Asp Arg Ile 
    50                  55                  60                  


Arg Gly Asn Gly Met Glu Pro Asp Ser Leu Asp Glu Glu Glu Ser Pro 
65                  70                  75                  80  


Arg Trp Gly Ser Leu His Glu Met Glu Glu Glu Ala Ser Gly Lys Ala 
                85                  90                  95      


Ala Gln Met Ala Arg Glu Gln Asn His His Thr Trp Asp Gln Gly Ala 
            100                 105                 110         


Asn Asn Arg Gln Gln Pro Ile Glu Asp Lys Tyr Ser Asp Leu Arg Tyr 
        115                 120                 125             


Asp Pro Asn Trp Lys Ser Lys Lys Glu Glu Gly Gln Leu Leu Ser Val 
    130                 135                 140                 


Glu Ala Leu Pro Glu Ser Thr Asp Ser Ser Leu Glu Asn Leu Pro Leu 
145                 150                 155                 160 


Ala Pro Leu Tyr Pro Ser Gln Glu Thr Ser Met Glu Leu Ser Gly Gly 
                165                 170                 175     


Lys Gly Glu Gln Lys Glu Ser Pro Gln Ser Ala Ala Ser Leu Leu Gly 
            180                 185                 190         


Ser Glu Phe Leu Ser Pro Asn Tyr Glu His Gly Ala Arg Arg Ser Lys 
        195                 200                 205             


Pro Phe Ser Glu Leu Ser Asp Ser Asp Leu Glu Glu Lys Ser Ser Ser 
    210                 215                 220                 


Leu Ser Pro Tyr Val Lys Ser Ser Ser Ser His Asn Glu Val Phe Leu 
225                 230                 235                 240 


Pro Gly Ser Arg Gly Pro Arg Arg Arg Lys Ser Lys Gln His Phe Val 
                245                 250                 255     


Glu Lys Asn Lys Leu Thr Leu Gly Leu Pro Thr Pro Lys Thr Asp Ser 
            260                 265                 270         


Tyr Leu Gln Leu His Asn Lys Lys Arg Gly Glu Ser His Pro Glu Gln 
        275                 280                 285             


Val Ile Leu Arg Val Asn Ser Leu Pro Arg Asp Gly Phe Lys Thr Phe 
    290                 295                 300                 


Trp Ser Gln 
305         


<210>  77
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Asp Ala Ile Leu Asn Tyr Arg Ser Glu Asp Thr Glu Asp Tyr Tyr 
1               5                   10                  15      


Thr Leu Leu Gly Cys Asp Glu Leu Ser Ser Val Glu Gln Ile Leu Ala 
            20                  25                  30          


Glu Phe Lys Val Arg Ala Leu Glu Cys His Pro Asp Lys His Pro Glu 
        35                  40                  45              


Asn Pro Lys Ala Val Glu Thr Phe Gln Lys Leu Gln Lys Ala Lys Glu 
    50                  55                  60                  


Ile Leu Thr Asn Glu Glu Ser Arg Ala Arg Tyr Asp His Trp Arg Arg 
65                  70                  75                  80  


Ser Gln Met Ser Met Pro Phe Gln Gln Trp Glu Ala Leu Asn Asp Ser 
                85                  90                  95      


Val Lys Thr Val Gly Phe Ser Leu Gly Ala Thr 
            100                 105         


<210>  78
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Trp Ile Lys Arg Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg 
1               5                   10                  15      


Leu Thr Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln 
            20                  25                  30          


Thr Val Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn 
        35                  40                  45              


Glu Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser 
    50                  55                  60                  


Gly Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu 
65                  70                  75                  80  


Gln Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln 
                85                  90                  95      


Glu Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys 
            100                 105                 110         


Thr Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu Ser 
        115                 120                 125             


Val Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser 
    130                 135                 140                 


Lys Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu 
145                 150                 155                 160 


Lys Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe 
                165                 170                 175     


Asn Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu 
            180                 185                 190         


Gly Gly Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile 
        195                 200                 205             


His Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg 
    210                 215                 220                 


Asp Gly Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val 
225                 230                 235                 240 


Thr Gly Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln 
                245                 250                 255     


Thr Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys 
            260                 265                 270         


Ala Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln 
        275                 280                 285             


Glu Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn 
    290                 295                 300                 


Lys Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp 
305                 310                 315                 320 


Lys Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro 
                325                 330                 335     


Val Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly 
            340                 345                 350         


Asp Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu 
        355                 360                 365             


Arg Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly 
    370                 375                 380                 


Glu Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly 
385                 390                 395                 400 


Trp Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg 
                405                 410                 415     


Asn Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro 
            420                 425                 430         


Glu Pro Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg 
        435                 440                 445             


Ala Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu 
    450                 455                 460                 


Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser 
465                 470                 475                 480 


Thr Ala Thr Val Val Ser 
                485     


<210>  79
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ser Gln Ala Gly Ala Gln Glu Ala Pro Ile Lys Lys Lys Arg Pro 
1               5                   10                  15      


Pro Val Lys Glu Glu Asp Leu Lys Gly Ala Arg Gly Asn Leu Thr Lys 
            20                  25                  30          


Asn Gln Glu Ile Lys Ser Lys Thr Tyr Gln Val Met Arg Glu Cys Glu 
        35                  40                  45              


Gln Ala Gly Ser Ala Ala Pro Ser Val Phe Ser Arg Thr Arg Thr Gly 
    50                  55                  60                  


Thr Glu Thr Val Phe Glu Lys Pro Lys Ala Gly Pro Thr Lys Ser Val 
65                  70                  75                  80  


Phe Gly 
        


<210>  80
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Glu Asp Ala Leu Asp Glu Leu Ile Lys Asp Cys Ala Gln Gln Leu 
1               5                   10                  15      


Phe Glu Leu Thr Asp Asp Lys Glu Asn Glu Arg Leu Ala Tyr Val Thr 
            20                  25                  30          


Tyr Gln Asp Ile His Ser Ile Gln Ala Phe His Glu Gln Ile Val Ile 
        35                  40                  45              


Ala Val Lys Ala Pro Ala Glu Thr Arg Leu Asp Val Pro Ala Pro Arg 
    50                  55                  60                  


Glu Asp Ser Ile Thr Val His Ile Arg Ser Thr Asn Gly Pro Ile Asp 
65                  70                  75                  80  


Val Tyr Leu Cys Glu Val Glu Gln Gly Gln Thr Ser Asn Lys Arg Ser 
                85                  90                  95      


Glu Gly Val Gly Thr Ser Ser Ser Glu Ser Thr His Pro Glu Gly Pro 
            100                 105                 110         


Glu Glu Glu Glu Asn Pro Gln Gln Ser Glu Glu Leu Leu Glu Val Ser 
        115                 120                 125             


Asn 
    


<210>  81
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Gly Pro Lys Arg Arg Gln Leu Thr Phe Arg Glu Lys Ser Arg Ile 
1               5                   10                  15      


Ile Gln Glu Val Glu Glu Asn Pro Asp Leu Arg Lys Gly Glu Ile Ala 
            20                  25                  30          


Arg Arg Phe Asn Ile Pro Pro Ser Thr Leu Ser Thr Ile Leu Lys Asn 
        35                  40                  45              


Lys Arg Ala Ile Leu Ala Ser Glu Arg Lys Tyr Gly Val Ala Ser Thr 
    50                  55                  60                  


Cys Arg Lys Thr Asn Lys Leu Ser Pro Tyr Asp Lys Leu Glu Gly Leu 
65                  70                  75                  80  


Leu Ile Ala Trp Phe Gln Gln Ile Arg Ala Ala Gly Leu Pro Val Lys 
                85                  90                  95      


Gly Ile Ile Leu Lys Glu Lys Ala Leu Arg Ile Ala Glu Glu Leu Gly 
            100                 105                 110         


Met Asp Asp Phe Thr Ala Ser Asn Gly Trp Leu Asp Arg Phe Arg Arg 
        115                 120                 125             


Arg His Gly Val Val Ser Cys Ser Gly Val Ala Arg Ala Arg Ala Arg 
    130                 135                 140                 


Asn Ala Ala Pro Arg Thr Pro Ala Ala Pro Ala Ser Pro Ala Ala Val 
145                 150                 155                 160 


Pro Ser Glu Gly Ser Gly Gly Ser Thr Thr Gly Trp Arg Ala Arg Glu 
                165                 170                 175     


Glu Gln Pro Pro Ser Val Ala Glu Gly Tyr Ala Ser Gln Asp Val Phe 
            180                 185                 190         


Ser Ala Thr Glu Thr Ser Leu Trp Tyr Asp Phe Leu Pro Asp Gln Ala 
        195                 200                 205             


Ala Gly Leu Cys Gly Gly Asp Gly Arg Pro Arg Gln Ala Thr Gln Arg 
    210                 215                 220                 


Leu Ser Val Leu Leu Cys Ala Asn Ala Asp Gly Ser Glu Lys Leu Pro 
225                 230                 235                 240 


Pro Leu Val Ala Gly Lys Ser Ala Lys Pro Arg Ala Gly Gln Ala Gly 
                245                 250                 255     


Leu Pro Cys Asp Tyr Thr Ala Asn Ser Lys Gly Gly Val Thr Thr Gln 
            260                 265                 270         


Ala Leu Ala Lys Tyr Leu Lys Ala Leu Asp Thr Arg Met Ala Ala Glu 
        275                 280                 285             


Ser Arg Arg Val Leu Leu Leu Ala Gly Arg Leu Ala Ala Gln Ser Leu 
    290                 295                 300                 


Asp Thr Ser Gly Leu Arg His Val Gln Leu Ala Phe Phe Pro Pro Gly 
305                 310                 315                 320 


Thr Val His Pro Leu Glu Arg Gly Val Val Gln Gln Val Lys Gly His 
                325                 330                 335     


Tyr Arg Gln Ala Met Leu Leu Lys Ala Met Ala Ala Leu Glu Gly Gln 
            340                 345                 350         


Asp Pro Ser Gly Leu Gln Leu Gly Leu Thr Glu Ala Leu His Phe Val 
        355                 360                 365             


Ala Ala Ala Trp Gln Ala Val Glu Pro Ser Asp Ile Ala Ala Cys Phe 
    370                 375                 380                 


Arg Glu Ala Gly Phe Gly Gly Gly Pro Asn Ala Thr Ile Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Ser Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                405                 410                 415     


Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu 
            420                 425                 430         


Glu Glu Glu Gly Gly Glu Gly Glu Glu Leu Gly Glu Glu Glu Glu Val 
        435                 440                 445             


Glu Glu Glu Gly Asp Val Asp Ser Asp Glu Glu Glu Glu Glu Asp Glu 
    450                 455                 460                 


Glu Ser Ser Ser Glu Gly Leu Glu Ala Glu Asp Trp Ala Gln Gly Val 
465                 470                 475                 480 


Val Glu Ala Gly Gly Ser Phe Gly Ala Tyr Gly Ala Gln Glu Glu Ala 
                485                 490                 495     


Gln Cys Pro Thr Leu His Phe Leu Glu Gly Gly Glu Asp Ser Asp Ser 
            500                 505                 510         


Asp Ser Glu Glu Glu Asp Asp Glu Glu Glu Asp Asp Glu Asp Glu Asp 
        515                 520                 525             


Asp Asp Asp Asp Glu Glu Asp Gly Asp Glu Val Pro Val Pro Ser Phe 
    530                 535                 540                 


Gly Glu Ala Met Ala Tyr Phe Ala Met Val Lys Arg Tyr Leu Thr Ser 
545                 550                 555                 560 


Phe Pro Ile Asp Asp Arg Val Gln Ser His Ile Leu His Leu Glu His 
                565                 570                 575     


Asp Leu Val His Val Thr Arg Lys Asn His Ala Arg Gln Ala Gly Val 
            580                 585                 590         


Arg Gly Leu Gly His Gln Ser 
        595                 


<210>  82
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  82

Lys Lys Val Glu Asp Leu Leu Asn Gln Ile Ser Leu Leu Lys Gln Asn 
1               5                   10                  15      


Leu Glu Ile Gln Leu Ser Gln Ser Gln Thr Ser Leu Gln Gln Leu Gln 
            20                  25                  30          


Ala Gln Phe Thr Gln Glu Arg Gln Arg Leu Thr Gln Glu Leu Glu Glu 
        35                  40                  45              


Leu Glu Glu Gln His Gln Gln Arg His Lys Ser Leu Lys Glu Ala His 
    50                  55                  60                  


Val Leu Ala Phe Gln Thr Met Glu Glu Glu Lys Glu Lys Glu Gln Arg 
65                  70                  75                  80  


Ala Leu Glu Asn His Leu Gln Gln Lys His Ser Ala Glu Leu Gln Ser 
                85                  90                  95      


Leu Lys Asp Ala His Arg Glu Ser Met Glu Gly Phe Arg Ile Glu Met 
            100                 105                 110         


Glu Gln Glu Leu Gln Thr Leu Arg Phe Glu Leu Glu Asp Glu Gly Lys 
        115                 120                 125             


Ala Met Leu Ala Ser Leu Arg Ser Glu Leu Asn His Gln His Ala Ala 
    130                 135                 140                 


Ala Ile Asp Leu Leu Arg His Asn His His Gln Glu Leu Ala Ala Ala 
145                 150                 155                 160 


Lys Met Glu Leu Glu Arg Ser Ile Asp Ile Ser Arg Arg Gln Ser Lys 
                165                 170                 175     


Glu His Ile Cys Arg Ile Thr Asp Leu Gln Glu Glu Leu Arg His Arg 
            180                 185                 190         


Glu His His Ile Ser Glu Leu Asp Lys Glu Val Gln His Leu His Glu 
        195                 200                 205             


Asn Ile Ser Ala Leu Thr Lys Glu Leu Glu Phe Lys Gly Lys Glu Ile 
    210                 215                 220                 


Leu Arg Ile Arg Ser Glu Ser Asn Gln Gln Ile Arg Leu His Glu Gln 
225                 230                 235                 240 


Asp Leu Asn Lys Arg Leu Glu Lys Glu Leu Asp Val Met Thr Ala Asp 
                245                 250                 255     


His Leu Arg Glu Lys Asn Ile Met Arg Ala Asp Phe Asn Lys Thr Asn 
            260                 265                 270         


Glu Leu Leu Lys Glu Ile Asn Ala Ala Leu Gln Val Ser Leu Glu Glu 
        275                 280                 285             


Met Glu Glu Lys Tyr Leu Met Arg Glu Ser Lys Pro Glu Asp Ile Gln 
    290                 295                 300                 


Met Ile Thr Glu Leu Lys Ala Met Leu Thr Glu Arg Asp Gln Ile Ile 
305                 310                 315                 320 


Lys Lys Leu Ile Glu Asp Asn Lys Phe Tyr Gln Leu Glu Leu Val Asn 
                325                 330                 335     


Arg Glu Thr Asn Phe Asn Lys Val Phe Asn Ser Ser Pro Thr Val Gly 
            340                 345                 350         


Val Ile Asn Pro Leu Ala Lys Gln Lys Lys Lys Asn Asp Lys Ser Pro 
        355                 360                 365             


Thr Asn Arg Phe Val Ser Val Pro Asn Leu Ser Ala Leu Glu Ser Gly 
    370                 375                 380                 


Gly Val Gly Asn Gly His Pro Asn Arg Leu Asp Pro Ile Pro Asn Ser 
385                 390                 395                 400 


Pro Val His Asp Ile Glu Phe Asn Ser Ser Lys Pro Leu Pro Gln Pro 
                405                 410                 415     


Val Pro Pro Lys Gly Pro Lys Thr Phe Leu Ser Pro Ala Gln Ser Glu 
            420                 425                 430         


Ala Ser Pro Val Ala Ser Pro Asp Pro Gln Arg Gln Glu Trp Phe Ala 
        435                 440                 445             


Arg Tyr Phe Thr Phe 
    450             


<210>  83
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Glu Val Met Glu Gly Pro Leu Asn Leu Ala His Gln Gln Ser Arg 
1               5                   10                  15      


Arg Ala Asp Arg Leu Leu Ala Ala Gly Lys Tyr Glu Glu Ala Ile Ser 
            20                  25                  30          


Cys His Lys Lys Ala Ala Ala Tyr Leu Ser Glu Ala Met Lys Leu Thr 
        35                  40                  45              


Gln Ser Glu Gln Ala His Leu Ser Leu Glu Leu Gln Arg Asp Ser His 
    50                  55                  60                  


Met Lys Gln Leu Leu Leu Ile Gln Glu Arg Trp Lys Arg Ala Gln Arg 
65                  70                  75                  80  


Glu Glu Arg Leu Lys Ala Gln Gln Asn Thr Asp Lys Asp Ala Ala Ala 
                85                  90                  95      


His Leu Gln Thr Ser His Lys Pro Ser Ala Glu Asp Ala Glu Gly Gln 
            100                 105                 110         


Ser Pro Leu Ser Gln Lys Tyr Ser Pro Ser Thr Glu Lys Cys Leu Pro 
        115                 120                 125             


Glu Ile Gln Gly Ile Phe Asp Arg Asp Pro Asp Thr Leu Leu Tyr Leu 
    130                 135                 140                 


Leu Gln Gln Lys Ser Glu Pro Ala Glu Pro Cys Ile Gly Ser Lys Ala 
145                 150                 155                 160 


Pro Lys Asp Asp Lys Thr Ile Ile Glu Glu Gln Ala Thr Lys Ile Ala 
                165                 170                 175     


Asp Leu Lys Arg His Val Glu Phe Leu Val Ala Glu Asn Glu Arg Leu 
            180                 185                 190         


Arg Lys Glu Asn Lys Gln Leu Lys Ala Glu Lys Ala Arg Leu Leu Lys 
        195                 200                 205             


Gly Pro Ile Glu Lys Glu Leu Asp Val Asp Ala Asp Phe Val Glu Thr 
    210                 215                 220                 


Ser Glu Leu Trp Ser Leu Pro Pro His Ala Glu Thr Ala Thr Ala Ser 
225                 230                 235                 240 


Ser Thr Trp Gln Lys Phe Ala Ala Asn Thr Gly Lys Ala Lys Asp Ile 
                245                 250                 255     


Pro Ile Pro Asn Leu Pro Pro Leu Asp Phe Pro Ser Pro Glu Leu Pro 
            260                 265                 270         


Leu Met Glu Leu Ser Glu Asp Ile Leu Lys Gly Phe Met Asn Asn 
        275                 280                 285         


<210>  84
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Glu Leu Gln Gln Leu Arg Val Gln Glu Ala Val Glu Ser Met 
1               5                   10                  15      


Val Lys Ser Leu Glu Arg Glu Asn Ile Arg Lys Met Gln Gly Leu Met 
            20                  25                  30          


Phe Arg Cys Ser Ala Ser Cys Cys Glu Asp Ser Gln Ala Ser Met Lys 
        35                  40                  45              


Gln Val His Gln Cys Ile Glu Arg Cys His Val Pro Leu Ala Gln Ala 
    50                  55                  60                  


Gln Ala Leu Val Thr Ser Glu Leu Glu Lys Phe Gln Asp Arg Leu Ala 
65                  70                  75                  80  


Arg Cys Thr Met His Cys Asn Asp Lys Ala Lys Asp Ser Ile Asp Ala 
                85                  90                  95      


Gly Ser Lys Glu Leu Gln Val Lys Gln Gln Leu Asp Ser Cys Val Thr 
            100                 105                 110         


Lys Cys Val Asp Asp His Met His Leu Ile Pro Thr Met Thr Lys Lys 
        115                 120                 125             


Met Lys Glu Ala Leu Leu Ser Ile Gly Lys 
    130                 135             


<210>  85
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Pro Val Glu Arg Met Arg Met Arg Pro Trp Leu Glu Glu Gln Ile 
1               5                   10                  15      


Asn Ser Asn Thr Ile Pro Gly Leu Lys Trp Leu Asn Lys Glu Lys Lys 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Met His Ala Ala Arg His Gly Trp Asp Val 
        35                  40                  45              


Glu Lys Asp Ala Pro Leu Phe Arg Asn Trp Ala Ile His Thr Gly Lys 
    50                  55                  60                  


His Gln Pro Gly Val Asp Lys Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Lys Ser Ile Lys Lys Gly Asn Asn Ala Phe Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Leu Ser Glu Arg Pro Ser Lys Lys Gly Lys Lys Pro Lys Thr Glu 
        115                 120                 125             


Lys Glu Asp Lys Val Lys His Ile Lys Gln Glu Pro Val Glu Ser Ser 
    130                 135                 140                 


Leu Gly Leu Ser Asn Gly Val Ser Asp Leu Ser Pro Glu Tyr Ala Val 
145                 150                 155                 160 


Leu Thr Ser Thr Ile Lys Asn Glu Val Asp Ser Thr Val Asn Ile Ile 
                165                 170                 175     


Val Val Gly Gln Ser His Leu Asp Ser Asn Ile Glu Asn Gln Glu Ile 
            180                 185                 190         


Val Thr Asn Pro Pro Asp Ile Cys Gln Val Val Glu Val Thr Thr Glu 
        195                 200                 205             


Ser Asp Glu Gln Pro Val Ser Met Ser Glu Leu Tyr Pro Leu Gln Ile 
    210                 215                 220                 


Ser Pro Val Ser Ser Tyr Ala Glu Ser Glu Thr Thr Asp Ser Val Pro 
225                 230                 235                 240 


Ser Asp Glu Glu Ser Ala Glu Gly Arg Pro His Trp Arg Lys Arg Asn 
                245                 250                 255     


Ile Glu Gly Lys Gln Tyr Leu Ser Asn Met Gly Thr Arg Gly Ser Tyr 
            260                 265                 270         


Leu Leu Pro Gly Met Ala Ser Phe Val Thr Ser Asn Lys Pro Asp Leu 
        275                 280                 285             


Gln Val Thr Ile Lys Glu Glu Ser Asn Pro Val Pro Tyr Asn Ser Ser 
    290                 295                 300                 


Trp Pro Pro Phe Gln Asp Leu Pro Leu Ser Ser Ser Met Thr Pro Ala 
305                 310                 315                 320 


Ser Ser Ser Ser Arg Pro Asp Arg Glu Thr Arg Ala Ser Val Ile Lys 
                325                 330                 335     


Lys Thr Ser Asp Ile Thr Gln Ala Arg Val Lys Ser Cys 
            340                 345                 


<210>  86
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Val Arg Pro Val Arg His Lys Lys Pro Val Asn Tyr Ser Gln Phe 
1               5                   10                  15      


Asp His Ser Asp Ser Asp Asp Asp Phe Val Ser Ala Thr Val Pro Leu 
            20                  25                  30          


Asn Lys Lys Ser Arg Thr Ala Pro Lys Glu Leu Lys Gln Asp Lys Pro 
        35                  40                  45              


Lys Pro Asn Leu Asn Asn Leu Arg Lys Glu Glu Ile Pro Val Gln Glu 
    50                  55                  60                  


Lys Thr Pro Lys Lys Arg Leu Pro Glu Gly Thr Phe Ser Ile Pro Ala 
65                  70                  75                  80  


Ser Ala Val Pro Cys Thr Lys Met Ala Leu Asp Asp Lys Leu Tyr Gln 
                85                  90                  95      


Arg Asp Leu Glu Val Ala Leu Ala Leu Ser Val Lys Glu Leu Pro Thr 
            100                 105                 110         


Val Thr Thr Asn Val Gln Asn Ser Gln Asp Lys Ser Ile Glu Lys His 
        115                 120                 125             


Gly Ser Ser Lys Ile Glu Thr Met Asn Lys Ser Pro His Ile Ser Asn 
    130                 135                 140                 


Cys Ser Val Ala Ser Asp Tyr Leu Asp Leu Asp Lys Ile Thr Val Glu 
145                 150                 155                 160 


Asp Asp Val Gly Gly Val Gln Gly Lys Arg Lys Ala Ala Ser Lys Ala 
                165                 170                 175     


Ala Ala Gln Gln Arg Lys Ile Leu Leu Glu Gly Ser Asp Gly Asp Ser 
            180                 185                 190         


Ala Asn Asp Thr Glu Pro Asp Phe Ala Pro Gly Glu Asp Ser Glu Asp 
        195                 200                 205             


Asp Ser Asp Phe Cys Glu Ser Glu Asp Asn Asp Glu Asp Phe Ser Met 
    210                 215                 220                 


Arg Lys Ser Lys Val Lys Glu Ile Lys Lys Lys Glu Val Lys Val Lys 
225                 230                 235                 240 


Ser Pro Val Glu Lys Lys Glu Lys Lys Ser Lys Ser Lys Cys Asn Ala 
                245                 250                 255     


Leu Val Thr Ser Val Asp Ser Ala Pro Ala Ala Val Lys Ser Glu Ser 
            260                 265                 270         


Gln Ser Leu Pro Lys Lys Val Ser Leu Ser Ser Asp Thr Thr Arg Lys 
        275                 280                 285             


Pro Leu Glu Ile Arg Ser Pro Ser Ala Glu Ser Lys Lys Pro Lys Trp 
    290                 295                 300                 


Val Pro Pro Ala Ala Ser Gly Gly Ser Arg Ser Ser Ser Ser Pro Leu 
305                 310                 315                 320 


Val Val Val Ser Val Lys Ser Pro Asn Gln Ser Leu Arg Leu Gly Leu 
                325                 330                 335     


Ser Arg Leu Ala Arg Val Lys Pro Leu His Pro Asn Ala Thr Ser Thr 
            340                 345                 350         


<210>  87
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ser Phe Arg Asp Leu Arg Asn Phe Thr Glu Met Met Arg Ala Leu 
1               5                   10                  15      


Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Thr Pro Asn Phe 
            20                  25                  30          


Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro 
        35                  40                  45              


Gln Thr Asp Ile Pro Pro Asp Val Asp Thr Glu Gln Asp Arg Val Phe 
    50                  55                  60                  


Phe Ile Lys Ala Ile Ala Gln Phe Met Ala Thr Lys Ala His Ile Lys 
65                  70                  75                  80  


Leu Asn Thr Lys Lys Leu Tyr Gln Ala Asp Gly Tyr Ala Val Lys Glu 
                85                  90                  95      


Leu Leu Lys Ile Thr Ser Val Leu Tyr Asn Ala Met Lys Thr Lys Gly 
            100                 105                 110         


Met Glu Gly Ser Glu Ile Val Glu Glu Asp Val Asn Lys Phe Lys Phe 
        115                 120                 125             


Asp Leu Gly Ser Lys Ile Ala Asp Leu Lys Ala Ala Arg Gln Leu Ala 
    130                 135                 140                 


Ser Glu Ile Thr Ser Lys Gly Ala Ser Leu Tyr Asp Leu Leu Gly Met 
145                 150                 155                 160 


Glu Val Glu Leu Arg Glu Met Arg Thr Glu Ala Ile Ala Arg Pro Leu 
                165                 170                 175     


Glu Ile Asn Glu Thr Glu Lys Val Met Arg Ile Ala Ile Lys Glu Ile 
            180                 185                 190         


Leu Thr Gln Val Gln Lys Thr Lys Asp Leu Leu Asn Asn Val Ala Ser 
        195                 200                 205             


Asp Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu 
    210                 215                 220                 


Glu Arg Asn Arg Lys Arg Leu Glu Thr Leu Gln Ser Val Arg Pro Cys 
225                 230                 235                 240 


Phe Met Asp Glu Tyr Glu Lys Thr Glu Glu Glu Leu Gln Lys Gln Tyr 
                245                 250                 255     


Asp Thr Tyr Leu Glu Lys Phe Gln Asn Leu Thr Tyr Leu Glu Gln Gln 
            260                 265                 270         


Leu Glu Asp His His Arg Met Glu Gln Glu Arg Phe Glu Glu Ala Lys 
        275                 280                 285             


Asn Thr Leu Cys Leu Ile Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg 
    290                 295                 300                 


Leu Leu Lys Ser Gly Ser Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu 
305                 310                 315                 320 


Asp Asp Glu Ser Asp Ser Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro 
                325                 330                 335     


Gln Thr Ala Met Glu Met Leu Met Gln Gly Arg Pro Gly Lys Arg Ile 
            340                 345                 350         


Val Gly Thr Met Gln Gly Gly Asp Ser Asp Asp Asn Glu Asp Ser Glu 
        355                 360                 365             


Glu Ser Glu Ile Asp Met Glu Asp Asp Asp Asp Glu Asp Asp Asp Leu 
    370                 375                 380                 


Glu Asp Glu Ser Ile Ser Leu Ser Pro Thr Lys Pro Asn Arg Arg Val 
385                 390                 395                 400 


Trp Lys Ser Glu Pro Leu Asp Glu Ser Asp Asn Asp Phe 
                405                 410             


<210>  88
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Glu Pro Asn Ser Pro Lys Lys Ile Gln Phe Ala Val Pro Val Phe 
1               5                   10                  15      


Gln Ser Gln Ile Ala Pro Glu Ala Ala Glu Gln Ile Arg Lys Arg Arg 
            20                  25                  30          


Pro Thr Pro Ala Ser Leu Val Ile Leu Asn Glu His Asn Pro Pro Glu 
        35                  40                  45              


Ile Asp Asp Lys Arg Gly Pro Asn Thr Gln Gly Glu Leu Gln Asn Ala 
    50                  55                  60                  


Ser Pro Lys Gln Arg Lys Gln Ser Val Tyr Thr Pro Pro Thr Ile Lys 
65                  70                  75                  80  


Gly Val Lys His Leu Lys Gly Gln Asn Glu Ser Ala Phe Pro Glu Glu 
                85                  90                  95      


Glu Glu Gly Thr Asn Glu Arg Glu Glu Gln Arg Asp His 
            100                 105                 


<210>  89
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Leu Glu Ser Ser Gly Cys Lys Ala Leu Lys Glu Gly Val Leu Glu 
1               5                   10                  15      


Lys Arg Ser Asp Gly Leu Leu Gln Leu Trp Lys Lys Lys Cys Cys Ile 
            20                  25                  30          


Leu Thr Glu Glu Gly Leu Leu Leu Ile Pro Pro Lys Gln Leu Gln His 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gly 
    50                  55                  60                  


Gln Gly Pro Ala Glu Pro Ser Gln Pro Ser Gly Pro Ala Val Ala Ser 
65                  70                  75                  80  


Leu Glu Pro Pro Val Lys Leu Lys Glu Leu His Phe Ser Asn Met Lys 
                85                  90                  95      


Thr Val Asp Cys Val Glu Arg Lys Gly Lys Tyr Met Tyr Phe Thr Val 
            100                 105                 110         


Val Met Ala Glu Gly Lys Glu Ile Asp Phe Arg Cys Pro Gln Asp Gln 
        115                 120                 125             


Gly Trp Asn Ala Glu Ile Thr Leu Gln Met Val Gln Tyr Lys Asn Arg 
    130                 135                 140                 


Gln Ala Ile Leu Ala Val Lys Ser Thr Arg Gln Lys Gln Gln His Leu 
145                 150                 155                 160 


Val Gln Gln Gln Pro Pro Ser Gln Pro Gln Pro Gln Pro Gln Leu Gln 
                165                 170                 175     


Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Ser Gln 
            180                 185                 190         


Pro Gln Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Gln Leu His Pro 
        195                 200                 205             


Tyr Pro His Pro His Pro His Pro His Ser His Pro His Ser His Pro 
    210                 215                 220                 


His Pro His Pro His Pro His Pro His Gln Ile Pro His Pro His Pro 
225                 230                 235                 240 


Gln Pro His Ser Gln Pro His Gly His Arg Leu Leu Arg Ser Thr Ser 
                245                 250                 255     


Asn Ser Ala 
            


<210>  90
<211>  743
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly His Arg Glu Ile Val Glu His Leu Leu Asp His Gly Ala Glu 
1               5                   10                  15      


Val Asn His Glu Asp Val Asp Gly Arg Thr Ala Leu Ser Val Ala Ala 
            20                  25                  30          


Leu Cys Val Pro Ala Ser Lys Gly His Ala Ser Val Val Ser Leu Leu 
        35                  40                  45              


Ile Asp Arg Gly Ala Glu Val Asp His Cys Asp Lys Asp Gly Met Thr 
    50                  55                  60                  


Pro Leu Leu Val Ala Ala Tyr Glu Gly His Val Asp Val Val Asp Leu 
65                  70                  75                  80  


Leu Leu Glu Gly Gly Ala Asp Val Asp His Thr Asp Asn Asn Gly Arg 
                85                  90                  95      


Thr Pro Leu Leu Ala Ala Ala Ser Met Gly His Ala Ser Val Val Asn 
            100                 105                 110         


Thr Leu Leu Phe Trp Gly Ala Ala Val Asp Ser Ile Asp Ser Glu Gly 
        115                 120                 125             


Arg Thr Val Leu Ser Ile Ala Ser Ala Gln Gly Asn Val Glu Val Val 
    130                 135                 140                 


Arg Thr Leu Leu Asp Arg Gly Leu Asp Glu Asn His Arg Asp Asp Ala 
145                 150                 155                 160 


Gly Trp Thr Pro Leu His Met Ala Ala Phe Glu Gly His Arg Leu Ile 
                165                 170                 175     


Cys Glu Ala Leu Ile Glu Gln Gly Ala Arg Thr Asn Glu Ile Asp Asn 
            180                 185                 190         


Asp Gly Arg Ile Pro Phe Ile Leu Ala Ser Gln Glu Gly His Tyr Asp 
        195                 200                 205             


Cys Val Gln Ile Leu Leu Glu Asn Lys Ser Asn Ile Asp Gln Arg Gly 
    210                 215                 220                 


Tyr Asp Gly Arg Asn Ala Leu Arg Val Ala Ala Leu Glu Gly His Arg 
225                 230                 235                 240 


Asp Ile Val Glu Leu Leu Phe Ser His Gly Ala Asp Val Asn Cys Lys 
                245                 250                 255     


Asp Ala Asp Gly Arg Pro Thr Leu Tyr Ile Leu Ala Leu Glu Asn Gln 
            260                 265                 270         


Leu Thr Met Ala Glu Tyr Phe Leu Glu Asn Gly Ala Asn Val Glu Ala 
        275                 280                 285             


Ser Asp Ala Glu Gly Arg Thr Ala Leu His Val Ser Cys Trp Gln Gly 
    290                 295                 300                 


His Met Glu Met Val Gln Val Leu Ile Ala Tyr His Ala Asp Val Asn 
305                 310                 315                 320 


Ala Ala Asp Asn Glu Lys Arg Ser Ala Leu Gln Ser Ala Ala Trp Gln 
                325                 330                 335     


Gly His Val Lys Val Val Gln Leu Leu Ile Glu His Gly Ala Val Val 
            340                 345                 350         


Asp His Thr Cys Asn Gln Gly Ala Thr Ala Leu Cys Ile Ala Ala Gln 
        355                 360                 365             


Glu Gly His Ile Asp Val Val Gln Val Leu Leu Glu His Gly Ala Asp 
    370                 375                 380                 


Pro Asn His Ala Asp Gln Phe Gly Arg Thr Ala Met Arg Val Ala Ala 
385                 390                 395                 400 


Lys Asn Gly His Ser Gln Ile Ile Lys Leu Leu Glu Lys Tyr Gly Ala 
                405                 410                 415     


Ser Ser Leu Asn Gly Cys Ser Pro Ser Pro Val His Thr Met Glu Gln 
            420                 425                 430         


Lys Pro Leu Gln Ser Leu Ser Ser Lys Val Gln Ser Leu Thr Ile Lys 
        435                 440                 445             


Ser Asn Ser Ser Gly Ser Thr Gly Gly Gly Asp Met Gln Pro Ser Leu 
    450                 455                 460                 


Arg Gly Leu Pro Asn Gly Pro Thr His Ala Phe Ser Ser Pro Ser Glu 
465                 470                 475                 480 


Ser Pro Asp Ser Thr Val Asp Arg Gln Lys Ser Ser Leu Ser Asn Asn 
                485                 490                 495     


Ser Leu Lys Ser Ser Lys Asn Ser Ser Leu Arg Thr Thr Ser Ser Thr 
            500                 505                 510         


Ala Thr Ala Gln Thr Val Pro Ile Asp Ser Phe His Asn Leu Ser Phe 
        515                 520                 525             


Thr Glu Gln Ile Gln Gln His Ser Leu Pro Arg Ser Arg Ser Arg Gln 
    530                 535                 540                 


Ser Ile Val Ser Pro Ser Ser Thr Thr Gln Ser Leu Gly Gln Ser His 
545                 550                 555                 560 


Asn Ser Pro Ser Ser Glu Phe Glu Trp Ser Gln Val Lys Pro Ser Leu 
                565                 570                 575     


Lys Ser Thr Lys Ala Ser Lys Gly Gly Lys Ser Glu Asn Ser Ala Lys 
            580                 585                 590         


Ser Gly Ser Ala Gly Lys Lys Ala Lys Gln Ser Asn Ser Ser Gln Pro 
        595                 600                 605             


Lys Val Leu Glu Tyr Glu Met Thr Gln Phe Asp Arg Arg Gly Pro Ile 
    610                 615                 620                 


Ala Lys Ser Gly Thr Ala Ala Pro Pro Lys Gln Met Pro Ala Glu Ser 
625                 630                 635                 640 


Gln Cys Lys Ile Met Ile Pro Ser Ala Gln Gln Glu Ile Gly Arg Ser 
                645                 650                 655     


Gln Gln Gln Phe Leu Ile His Gln Gln Ser Gly Glu Gln Lys Lys Arg 
            660                 665                 670         


Asn Gly Ile Met Thr Asn Pro Asn Tyr His Leu Gln Ser Asn Gln Val 
        675                 680                 685             


Phe Leu Gly Arg Val Ser Val Pro Arg Thr Met Gln Asp Arg Gly His 
    690                 695                 700                 


Gln Glu Val Leu Glu Gly Tyr Pro Ser Ser Glu Thr Glu Leu Ser Leu 
705                 710                 715                 720 


Lys Gln Ala Leu Lys Leu Gln Ile Glu Gly Ser Asp Pro Ser Phe Asn 
                725                 730                 735     


Tyr Lys Lys Glu Thr Pro Leu 
            740             


<210>  91
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Leu Lys Arg Lys Pro Ser Asn Val Ser Glu Lys Glu Lys His Gln 
1               5                   10                  15      


Lys Pro Lys Arg Ser Ser Ser Phe Gly Asn Phe Asp Arg Phe Arg Asn 
            20                  25                  30          


Asn Ser Leu Ser Lys Pro Asp Asp Ser Thr Glu Ala His Glu Gly Asp 
        35                  40                  45              


Pro Thr Asn Gly Ser Gly Glu Gln Ser Lys Thr Ser Asn Asn Gly Gly 
    50                  55                  60                  


Gly Leu Gly Lys Lys Met Arg Ala Ile Ser Trp Thr Met Lys Lys Lys 
65                  70                  75                  80  


Val Gly Lys Lys Tyr Ile Lys Ala Leu Ser Glu Glu Lys Asp Glu Glu 
                85                  90                  95      


Asp Gly Glu Asn Ala His Pro Tyr Arg Asn Ser Asp Pro Val Ile Gly 
            100                 105                 110         


Thr His Thr Glu Lys Val Ser Leu Lys Ala Ser Asp Ser Met Asp Ser 
        115                 120                 125             


Leu Tyr Ser Gly Gln Ser Ser Ser Ser Gly Ile Thr Ser Cys Ser Asp 
    130                 135                 140                 


Gly Thr Ser Asn Arg Asp Ser Phe Arg Leu Asp Asp Asp Gly Pro Tyr 
145                 150                 155                 160 


Ser Gly Pro Phe Cys Gly Arg Ala Arg Val His Thr Asp Phe Thr Pro 
                165                 170                 175     


Ser Pro Tyr Asp Thr Asp Ser Leu Lys Ile Lys Lys Gly Asp Ile Ile 
            180                 185                 190         


Asp Ile Ile Cys Lys Thr Pro Met Gly Met Trp Thr Gly Met Leu Asn 
        195                 200                 205             


Asn Lys Val Gly Asn Phe Lys Phe Ile Tyr Val Asp Val Ile Ser Glu 
    210                 215                 220                 


Glu Glu Ala Ala Pro Lys Lys Ile Lys Ala Asn Arg Arg Ser Asn Ser 
225                 230                 235                 240 


Lys Lys Ser Lys Thr Leu Gln Glu Phe Leu Glu Arg Ile His Leu Gln 
                245                 250                 255     


Glu Tyr Thr Ser Thr Leu Leu Leu Asn Gly Tyr Glu Thr Leu Glu Asp 
            260                 265                 270         


Leu Lys Asp Ile Lys Glu Ser His Leu Ile Glu Leu Asn Ile Glu Asn 
        275                 280                 285             


Pro Asp Asp Arg Arg Arg Leu Leu Ser Ala Ala Glu Asn Phe Leu Glu 
    290                 295                 300                 


Glu Glu Ile Ile Gln Glu Gln Glu Asn Glu Pro Glu Pro Leu Ser Leu 
305                 310                 315                 320 


Ser Ser Asp Ile Ser Leu Asn Lys Ser Gln Leu Asp Asp Cys Pro Arg 
                325                 330                 335     


Asp Ser Gly Cys Tyr Ile Ser Ser Gly Asn Ser Asp Asn Gly Lys Glu 
            340                 345                 350         


Asp Leu Glu Ser Glu Asn Leu Ser Asp Met Val His Lys Ile Ile Ile 
        355                 360                 365             


Thr Glu Pro Ser Asp 
    370             


<210>  92
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Pro Gln Ser Phe Ser Ala Ile Thr Leu Ser Asn Thr Glu Met Asn 
1               5                   10                  15      


Asn Ile Lys Thr Asn Ala Gln Arg Asn Lys Leu Pro Ile Glu Glu Leu 
            20                  25                  30          


Gly Lys Val Ser Lys His Lys Ile Ala Thr Lys Arg Thr Pro His Lys 
        35                  40                  45              


Glu Asp Glu Ala Met Ser Cys Ser Glu Asn Cys Ser Ser Ala Gln Gly 
    50                  55                  60                  


Asp Ser Phe Gln Asp Glu Ser Gln Gly Ser His Ser Glu Ser Ser Ser 
65                  70                  75                  80  


Asn Pro Ser Asn Pro Glu Thr Leu His Ala Lys Ala Thr Asp Ser Val 
                85                  90                  95      


Leu Gln Gly Ser Glu Gly Asn Lys Val Lys Arg Thr Ser Cys Met Tyr 
            100                 105                 110         


Gly Ala Asn Cys Tyr Arg Lys Asn Pro Val His Phe Gln His Phe Ser 
        115                 120                 125             


His Pro Gly Asp Ser Asp Tyr Gly Gly Val Gln Ile Val Gly Gln Asp 
    130                 135                 140                 


Glu Thr Asp Asp Arg Pro Glu Cys Pro Tyr Gly Pro Ser Cys Tyr Arg 
145                 150                 155                 160 


Lys Asn Pro Gln His Lys Ile Glu Tyr Arg His Asn Thr Leu Pro Glu 
                165                 170                 175     


Ala Asp Ser Ala His Asn Ile Ser Ala His Arg Met Arg Lys 
            180                 185                 190 


<210>  93
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Arg Thr Trp Glu Gln Gln 
225                 230                 235                 240 


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
                245                 250                 255     


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser 
            260                 265                 270         


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
        275                 280                 285             


Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
305                 310                 315                 320 


Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
                325                 330                 335     


Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
            340                 345                 350         


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
        355                 360                 365             


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
    370                 375                 380                 


Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly 
385                 390                 395                 400 


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
                405                 410                 415     


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430 


<210>  94
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Ser Pro Gly Lys Pro Gly Ala Asp Glu Ala Gln Glu Glu Glu 
1               5                   10                  15      


Gly Glu Leu Glu Gly Gly Ser Ala Gly Pro Arg Ala Ala Ile Leu Glu 
            20                  25                  30          


Gln Ala Glu Glu Leu Phe Leu Leu Cys Asp Lys Glu Ala Lys Gly Phe 
        35                  40                  45              


Ile Thr Lys His Asp Leu Gln Gly Leu Gln Ser Asp Leu Pro Leu Thr 
    50                  55                  60                  


Pro Glu Gln Leu Glu Ala Val Phe Glu Ser Leu Asp Gln Ala His Thr 
65                  70                  75                  80  


Gly Phe Leu Thr Ala Arg Glu Phe Cys Leu Gly Leu Gly Met Phe Val 
                85                  90                  95      


Gly Val Ala Ser Ala Gln Gly Ala Asn Pro Cys Arg Thr Pro Glu Glu 
            100                 105                 110         


Thr Phe Glu Ser Gly Gly Leu Asp Val Gln Gly Thr Ala Gly Ser Leu 
        115                 120                 125             


Asp Glu Glu Glu Glu Glu Glu Glu Arg Phe His Thr Val Leu Glu Gln 
    130                 135                 140                 


Leu Gly Val Ala Pro Val Leu Gly Glu Gln Arg Ala Val Arg Thr Leu 
145                 150                 155                 160 


Trp Ala Arg Leu Gln Arg Glu Arg Pro Glu Leu Leu Gly Ser Phe Glu 
                165                 170                 175     


Asp Val Leu Ile Arg Ala Ser Ala Cys Leu Glu Glu Ala Ala Arg Glu 
            180                 185                 190         


Arg Asp Gly Leu Glu Gln Ala Leu Arg Arg Arg Glu Ser Glu His Glu 
        195                 200                 205             


Arg Glu Val Arg Ala Leu Tyr Glu Glu Thr Glu Gln Leu Arg Glu Gln 
    210                 215                 220                 


Ser Arg Arg Pro Pro Ser Gln Asn Phe Ala Arg Gly Glu Arg Arg Ser 
225                 230                 235                 240 


Arg Leu Glu Leu Glu Leu Gln Ile Arg Glu Gln Asp Leu Glu Arg Ala 
                245                 250                 255     


Gly Leu Arg Gln Arg Glu Arg Arg Gly Arg Arg Leu Gln Glu His Ala 
            260                 265                 270         


Glu Arg Glu Ser Gln Pro Ala Thr Ala Thr Gly Ala Ala Gln Gly Ala 
        275                 280                 285             


Glu Tyr Thr Ala Ala Gly 
    290                 


<210>  95
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ala Glu Ala Asp Phe Lys Met Val Ser Glu Pro Val Ala His Gly 
1               5                   10                  15      


Val Ala Glu Glu Glu Met Ala Ser Ser Thr Ser Asp Ser Gly Glu Glu 
            20                  25                  30          


Ser Asp Ser Ser Ser Ser Ser Ser Ser Thr Ser Asp Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Thr Ser Gly Ser Ser Ser Gly Ser Gly Ser Ser Ser Ser Ser 
    50                  55                  60                  


Ser Gly Ser Thr Ser Ser Arg Ser Arg Leu Tyr Arg Lys Lys Arg Val 
65                  70                  75                  80  


Pro Glu Pro Ser Arg Arg Ala Arg Arg Ala Pro Leu Gly Thr Asn Phe 
                85                  90                  95      


Val Asp Arg Leu Pro Gln Ala Val Arg Asn Arg Val Gln Ala Leu Arg 
            100                 105                 110         


Asn Ile Gln Asp Glu Cys Asp Lys Val Asp Thr Leu Phe Leu Lys Ala 
        115                 120                 125             


Ile His Asp Leu Glu Arg Lys Tyr Ala Glu Leu Asn Lys Pro Leu Tyr 
    130                 135                 140                 


Asp Arg Arg Phe Gln Ile Ile Asn Ala Glu Tyr Glu Pro Thr Glu Glu 
145                 150                 155                 160 


Glu Cys Glu Trp Asn Ser Glu Asp Glu Glu Phe Ser Ser Asp Glu Glu 
                165                 170                 175     


Val Gln Asp Asn Thr Pro Ser Glu Met Pro Pro Leu Glu Gly Glu Glu 
            180                 185                 190         


Glu Glu Asn Pro Lys Glu Asn Pro Glu Val Lys Ala Glu Glu Lys Glu 
        195                 200                 205             


Val Pro Lys Glu Ile Pro Glu Val Lys Asp Glu Glu Lys Glu Val Ala 
    210                 215                 220                 


Lys Glu Ile Thr Glu Val Lys Ala Glu Glu Lys Ala Asp Ser Lys Asp 
225                 230                 235                 240 


Cys Met Glu Ala Thr Pro Glu Val Lys Glu Asp Pro Lys Glu Val Pro 
                245                 250                 255     


Gln Val Lys Ala Asp Asp Lys Glu Gln Pro Lys Ala Thr Glu Ala Lys 
            260                 265                 270         


Ala Arg Ala Ala Val Arg Glu Thr His Lys Arg Val Pro Glu Glu Arg 
        275                 280                 285             


Leu Gln Asp Ser Val Asp Leu Lys Arg Ala Arg Lys Gly Lys Pro Lys 
    290                 295                 300                 


Arg Glu Asp Pro Lys Gly Ile Pro Asp Tyr Trp Leu Ile Val Leu Lys 
305                 310                 315                 320 


Asn Val Asp Lys Leu Gly Pro Met Ile Gln Lys Tyr Asp Glu Pro Ile 
                325                 330                 335     


Leu Lys Phe Leu Ser Asp Val Ser Leu Lys Phe Ser Lys Pro Gly Gln 
            340                 345                 350         


Pro Val Ser Tyr Thr Phe Glu Phe His Phe Leu Pro Asn Pro Tyr Phe 
        355                 360                 365             


Arg Asn Glu Val Leu Val Lys Thr Tyr Ile Ile Lys Ala Lys Pro Asp 
    370                 375                 380                 


His Asn Asp Pro Phe Phe Ser Trp Gly Trp Glu Ile Glu Asp Cys Lys 
385                 390                 395                 400 


Gly Cys Lys Ile Asp Trp Arg Arg Gly Lys Asp Val Thr Val Thr Thr 
                405                 410                 415     


Thr Gln Ser Arg Thr Thr Ala Thr Gly Glu Ile Glu Ile Gln Pro Arg 
            420                 425                 430         


Val Val Pro Asn Ala Ser Phe Phe Asn Phe Phe Ser Pro Pro Glu Ile 
        435                 440                 445             


Pro Met Ile Gly Lys Leu Glu Pro Arg Glu Asp Ala Ile Leu Asp Glu 
    450                 455                 460                 


Asp Phe Glu Ile Gly Gln Ile Leu His Asp Asn Val Ile Leu Lys Ser 
465                 470                 475                 480 


Ile Tyr Tyr Tyr Thr Gly Glu Val Asn Gly Thr Tyr Tyr Gln Phe Gly 
                485                 490                 495     


Lys His Tyr Gly Asn Lys Lys Tyr Arg Lys 
            500                 505     


<210>  96
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  96

Tyr Pro Gln Gly Arg His Pro Ala Pro His Gln Pro Gly Gln Pro Gly 
1               5                   10                  15      


Phe Lys Phe Thr Val Ala Glu Ser Cys Asp Arg Ile Lys Asp Glu Phe 
            20                  25                  30          


Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Val Glu Tyr Asp Lys 
        35                  40                  45              


Leu Ala Asn Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr Tyr 
    50                  55                  60                  


Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu Ile 
65                  70                  75                  80  


Ala Lys Arg Leu Asn Thr Ile Leu Ala Gln Ile Met Pro Phe Leu Ser 
                85                  90                  95      


Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys Gln 
            100                 105                 110         


Val Thr Met Thr Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu Gln 
        115                 120                 125             


Ala Gln His Leu Ser His Ala Thr His Gly Pro Pro Val Gln Leu Pro 
    130                 135                 140                 


Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Val Thr Gly 
145                 150                 155                 160 


Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala Leu Gly Ser Gln Ala His 
                165                 170                 175     


Leu Thr Val Lys Asp Glu Lys Asn His His Glu Leu Asp His Arg Glu 
            180                 185                 190         


Arg Glu Ser Ser Ala Asn Asn Ser Val Ser Pro Ser Glu Ser Leu Arg 
        195                 200                 205             


Ala Ser Glu Lys His Arg Gly Ser Ala Asp Tyr Ser Met Glu Ala Lys 
    210                 215                 220                 


Lys Arg Lys Ala Glu Glu Lys Asp Ser Leu Ser Arg Tyr Asp Ser Asp 
225                 230                 235                 240 


Gly Asp Lys Ser Asp Asp Leu Val Val Asp Val Ser Asn Glu Asp Pro 
                245                 250                 255     


Ala Thr Pro Arg Val Ser Pro Ala His Ser Pro Pro Glu Asn Gly Leu 
            260                 265                 270         


Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala Pro Thr Ser Pro Ala Ser 
        275                 280                 285             


Val Ala Ser Ser Ser Ser Thr Pro Ser Ser Lys Thr Lys Asp Leu Gly 
    290                 295                 300                 


His Asn Asp Lys Ser Ser Thr Pro Gly Leu Lys Ser Asn Thr Pro Thr 
305                 310                 315                 320 


Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr Ser Thr Thr Pro Gly Leu 
                325                 330                 335     


Arg Ser Met Pro Gly Lys Pro Pro Gly Met Asp Pro Ile Gly Ile Met 
            340                 345                 350         


Ala Ser Ala Leu Arg Thr Pro Ile Ser Ile Thr Ser Ser Tyr Ala Ala 
        355                 360                 365             


Pro Phe Ala Met Met Ser His His Glu Met Asn Gly Ser Leu Thr Ser 
    370                 375                 380                 


Pro Gly Ala Tyr Ala Gly Leu His Asn Ile Pro Pro Gln Met Ser Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Tyr Gly Arg Ser Pro Met Val Gly 
                405                 410                 415     


Phe Asp Pro His Pro Pro Met Arg Ala Thr Gly Leu Pro Ser Ser Leu 
            420                 425                 430         


Ala Ser Ile Pro Gly Gly Lys Pro Ala Tyr Ser Phe His Val Ser Ala 
        435                 440                 445             


Asp Gly Gln Met Gln Pro Val Pro Phe Pro His Asp Ala Leu Ala Gly 
    450                 455                 460                 


Pro Gly Ile Pro Arg His Ala Arg Gln Ile Asn Thr Leu Ser His Gly 
465                 470                 475                 480 


Glu Val Val Cys Ala Val Thr Ile Ser Asn Pro Thr Arg His Val Tyr 
                485                 490                 495     


Thr Gly Gly Lys Gly Cys Val Lys Ile Trp Asp Ile Ser Gln Pro Gly 
            500                 505                 510         


Ser Lys Ser Pro Ile Ser Gln Leu Asp Cys Leu Asn Arg Asp Asn Tyr 
        515                 520                 525             


Ile Arg Ser Cys Lys Leu Leu Pro Asp Gly Arg Thr Leu Ile Val Gly 
    530                 535                 540                 


Gly Glu Ala Ser Thr Leu Thr Ile Trp Asp Leu Ala Ser Pro Thr Pro 
545                 550                 555                 560 


Arg Ile Lys Ala Glu Leu Thr Ser Ser Ala Pro Ala Cys Tyr Ala Leu 
                565                 570                 575     


Ala Ile Ser Pro Asp Ala Lys Val Cys Phe Ser Cys Cys Ser Asp Gly 
            580                 585                 590         


Asn Ile Ala Val Trp Asp Leu His Asn Gln Thr Leu Val Arg Gln Phe 
        595                 600                 605             


Gln Gly His Thr Asp Gly Ala Ser Cys Ile Asp Ile Ser His Asp Gly 
    610                 615                 620                 


Thr Lys Leu Trp Thr Gly Gly Leu Asp Asn Thr Val Arg Ser Trp Asp 
625                 630                 635                 640 


Leu Arg Glu Gly Arg Gln Leu Gln Gln His Asp Phe Thr Ser Gln Ile 
                645                 650                 655     


Phe Ser Leu Gly Tyr Cys Pro Thr Gly Glu Trp Leu Ala Val Gly Met 
            660                 665                 670         


Glu Ser Ser Asn Val Glu Val Leu His His Thr Lys Pro Asp Lys Tyr 
        675                 680                 685             


Gln Leu His Leu His Glu Ser Cys Val Leu Ser Leu Lys Phe Ala Tyr 
    690                 695                 700                 


Cys Gly Lys Trp Phe Val Ser Thr Gly Lys Asp Asn Leu Leu Asn Ala 
705                 710                 715                 720 


Trp Arg Thr Pro Tyr Gly Ala Ser Ile Phe Gln Ser Lys Glu Ser Ser 
                725                 730                 735     


Ser Val Leu Ser Cys Asp Ile Ser Ala Asp Asp Lys Tyr Ile Val Thr 
            740                 745                 750         


Gly Ser Gly Asp Lys Lys Ala Thr Val Tyr Glu Val Ile Tyr 
        755                 760                 765     


<210>  97
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Ala Glu Ala Gly Thr Gly Leu Leu Pro Ala Thr Val Gln Pro Phe 
1               5                   10                  15      


His Leu Arg Gly Met Ser Ser Thr Phe Ser Gln Arg Ser Arg Asp Ile 
            20                  25                  30          


Phe Asp Cys Leu Glu Gly Ala Ala Arg Arg Ala Pro Ser Ser Val Ala 
        35                  40                  45              


His Thr Ser Met Ser Asp Asn Gly Gly Phe Lys Arg Pro Leu Ala Pro 
    50                  55                  60                  


Ser Gly Arg Ser Pro Val Glu Gly Leu Gly Arg Ala His Arg Ser Pro 
65                  70                  75                  80  


Ala Ser Pro Arg Val Pro Pro Val Pro Asp Tyr Val Ala His Pro Glu 
                85                  90                  95      


Arg Trp Thr Lys Tyr Ser Leu Glu Asp Val Thr Glu Val Ser Glu Gln 
            100                 105                 110         


Ser Asn Gln Ala Thr Ala Leu Ala Phe Leu Gly Ser Gln Ser Leu Ala 
        115                 120                 125             


Ala Pro Thr Asp Cys Val Ser Ser Phe Asn Gln Asp Pro Ser Ser Cys 
    130                 135                 140                 


Gly Glu Gly Arg Val Ile Phe Thr Lys Pro Val Arg Gly Val Glu Ala 
145                 150                 155                 160 


Arg His Glu Arg Lys Arg Val Leu Gly Lys Val Gly Glu Pro Gly Arg 
                165                 170                 175     


Gly Gly Leu Gly Asn Pro Ala Thr Asp Arg Gly Glu Gly Pro Val Glu 
            180                 185                 190         


Leu Ala His Leu Ala Gly Pro Gly Ser Pro Glu Ala Glu Glu Trp Gly 
        195                 200                 205             


Ser Pro His Gly Gly Leu Gln Glu Val Glu Ala Leu Ser Gly Ser Val 
    210                 215                 220                 


His Ser Gly Ser Val Pro Gly Leu Pro Pro Val Glu Thr Val Gly Phe 
225                 230                 235                 240 


His Gly Ser Arg Lys Arg Ser Arg Asp His Phe Arg Asn Lys Ser Ser 
                245                 250                 255     


Ser Pro Glu Asp Pro Gly Ala Glu Val 
            260                 265 


<210>  98
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Ile Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Thr Pro Gly Lys 
    50                  55                  60                  


Ala Pro Arg Ile Leu Ile Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Ser Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  99
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Glu Pro Glu Ala Phe Glu Ile Cys Pro Tyr Asp Pro His His Arg 
1               5                   10                  15      


Ile Pro Leu Ser Arg Phe Gln Tyr His Leu Ala Ser Cys Arg Arg Lys 
            20                  25                  30          


Asn Pro Lys Lys Ala Lys Lys Met Ala Thr Cys Lys Tyr Asn Ala Cys 
        35                  40                  45              


His Val Val Pro Ile Lys Asn Leu Glu Glu His Glu Ala Val Cys Val 
    50                  55                  60                  


Asn Arg Ser Ala Val Glu Glu Glu Asp Thr Glu Asn Pro Leu Lys Val 
65                  70                  75                  80  


Ser Pro Pro Ser Ser Glu Gln Asn Asp Asp Thr Gln Gln Val Ser Pro 
                85                  90                  95      


Cys Leu Pro Ser Pro Asp Ile Trp Asn Val Asp Gly Ala Asn Cys Gln 
            100                 105                 110         


His Val Phe Val Leu Lys Thr Phe Phe Pro Gln Lys Val Val Cys Glu 
        115                 120                 125             


Asn Asp Thr Lys Glu Ser Ala Arg Glu Thr Ser Pro Gln Lys Ile Leu 
    130                 135                 140                 


Arg Pro Gly Gln 
145             


<210>  100
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Thr Ser Lys Gly Pro Glu Glu Glu His Pro Ser Val Thr Leu Phe 
1               5                   10                  15      


Arg Gln Tyr Leu Arg Ile Arg Thr Val Gln Pro Lys Pro Asp Tyr Gly 
            20                  25                  30          


Ala Ala Val Ala Phe Phe Glu Glu Thr Ala Arg Gln Leu Gly Leu Gly 
        35                  40                  45              


Cys Gln Lys Val Glu Val Ala Pro Gly Tyr Val Val Thr Val Leu Thr 
    50                  55                  60                  


Trp Pro Gly Thr Asn Pro Thr Leu Ser Ser Ile Leu Leu Asn Ser His 
65                  70                  75                  80  


Thr Asp Val Val Pro Val Phe Lys Glu His Trp Ser His Asp Pro Phe 
                85                  90                  95      


Glu Ala Phe Lys Asp Ser Glu Gly Tyr Ile Tyr Ala Arg Gly Ala Gln 
            100                 105                 110         


Asp Met Lys Cys Val Ser Ile Gln Tyr Leu Glu Ala Val Arg Arg Leu 
        115                 120                 125             


Lys Val Glu Gly His Arg Phe Pro Arg Thr Ile His Met Thr Phe Val 
    130                 135                 140                 


Pro Asp Glu Glu Val Gly Gly His Gln Gly Met Glu Leu Phe Val Gln 
145                 150                 155                 160 


Arg Pro Glu Phe His Ala Leu Arg Ala Gly Phe Ala Leu Asp Glu Gly 
                165                 170                 175     


Ile Ala Asn Pro Thr Asp Ala Phe Thr Val Phe Tyr Ser Glu Arg Ser 
            180                 185                 190         


Pro Trp Trp Val Arg Val Thr Ser Thr Gly Arg Pro Gly His Ala Ser 
        195                 200                 205             


Arg Phe Met Glu Asp Thr Ala Ala Glu Lys Leu His Lys Val Val Asn 
    210                 215                 220                 


Ser Ile Leu Ala Phe Arg Glu Lys Glu Trp Gln Arg Leu Gln Ser Asn 
225                 230                 235                 240 


Pro His Leu Lys Glu Gly Ser Val Thr Ser Val Asn Leu Thr Lys Leu 
                245                 250                 255     


Glu Gly Gly Val Ala Tyr Asn Val Ile Pro Ala Thr Met Ser Ala Ser 
            260                 265                 270         


Phe Asp Phe Arg Val Ala Pro Asp Val Asp Phe Lys Ala Phe Glu Glu 
        275                 280                 285             


Gln Leu Gln Ser Trp Cys Gln Ala Ala Gly Glu Gly Val Thr Leu Glu 
    290                 295                 300                 


Phe Ala Gln Lys Trp Met His Pro Gln Val Thr Pro Thr Asp Asp Ser 
305                 310                 315                 320 


Asn Pro Trp Trp Ala Ala Phe Ser Arg Val Cys Lys Asp Met Asn Leu 
                325                 330                 335     


Thr Leu Glu Pro Glu Ile Met Pro Ala Ala Thr Asp Asn Arg Tyr Ile 
            340                 345                 350         


Arg Ala Val Gly Val Pro Ala Leu Gly Phe Ser Pro Met Asn Arg Thr 
        355                 360                 365             


Pro Val Leu Leu His Asp His Asp Glu Arg Leu His Glu Ala Val Phe 
    370                 375                 380                 


Leu Arg Gly Val Asp Ile Tyr Thr Arg Leu Leu Pro Ala Leu Ala Ser 
385                 390                 395                 400 


Val Pro Ala Leu Pro Ser Asp Ser His Met 
                405                 410 


<210>  101
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Arg Arg Ser Ser Gly Phe Gly Gly Gln Lys Gly Gln Gly Pro Ser 
1               5                   10                  15      


Cys Ser Phe Thr Gly Cys Trp Cys Cys Arg Gly Asp Asp Val Ala Glu 
            20                  25                  30          


Ser Asp Asp Ser Pro Phe Ala Gln Cys Gly Tyr Asn Ile Gln Glu Lys 
        35                  40                  45              


His Leu Gly Lys Leu His Arg Ala Ala Ser Arg Gly Glu Val Ser Lys 
    50                  55                  60                  


Val Glu Cys Ile Leu Ser Ser Gly Ser Ala Asp Leu Asp Glu Arg Asp 
65                  70                  75                  80  


Lys Lys Lys Arg Thr Ala Leu His Leu Ala Cys Ala Asn Gly His Pro 
                85                  90                  95      


Glu Val Val Ala Leu Leu Val Asp Arg Gly Cys Gln Leu Asp Val Phe 
            100                 105                 110         


Asp Asn Lys Asn Arg Thr Ala Leu Leu Lys Ala Val Gln Cys Gln Glu 
        115                 120                 125             


Glu Glu Cys Ala Thr Ile Leu Leu Glu His Gly Ala Asp Pro Asp Leu 
    130                 135                 140                 


Pro Asp Val Tyr Gly Asn Thr Thr Leu His Tyr Ala Ile Tyr Asn Glu 
145                 150                 155                 160 


Asp Ile Pro Met Thr Lys Lys Leu Leu Leu His His Ala Asn Ile Glu 
                165                 170                 175     


Ser Ala Asn Lys Asp Glu Leu Thr Pro Phe Leu Leu Ala Val His Glu 
            180                 185                 190         


Gln Lys Gln Gln Met Glu Asp Phe Leu Arg Lys Gln Lys Glu Asn Leu 
        195                 200                 205             


Thr Ala Val Lys Leu Glu Ser Ile His Gln Val Met Ser Glu Tyr Lys 
    210                 215                 220                 


Glu Asn Glu Thr Pro Arg Asn Pro Gln Asn Ser Asn Pro Glu Gly Thr 
225                 230                 235                 240 


Ser Asn Lys Met Ala Cys Leu Gly Glu Gly Ala Ala Gly Ala Lys Val 
                245                 250                 255     


Asp Glu Ile Pro Gly Asn Pro Val Thr Arg Leu Phe Asn Lys Pro Ser 
            260                 265                 270         


Ile Asp Asp Ser Arg Pro Met Ser Ala Asn Glu Asp Phe Asp Phe Asp 
        275                 280                 285             


Thr Glu Glu Lys Ala Thr Glu Pro Ala Asn Gly Lys Arg Gln Asn Gly 
    290                 295                 300                 


Met Gly Ile Ile Glu Ser Ala Pro Gln Glu His Thr Asn Asn Glu Asn 
305                 310                 315                 320 


Ile 
    


<210>  102
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Glu Gln Pro Thr Ser Ser Thr Asn Gly Glu Lys Thr Lys Ser Pro 
1               5                   10                  15      


Cys Glu Ser Asn Asn Lys Lys Asn Asp Glu Met Gln Glu Val Pro Asn 
            20                  25                  30          


Arg Val Leu Ala Pro Glu Gln Ser Leu Lys Lys Thr Lys Thr Ser Glu 
        35                  40                  45              


Tyr Pro Ile Ile Phe Val Tyr Tyr Leu Arg Lys Gly Lys Lys Ile Asn 
    50                  55                  60                  


Ser Asn Gln Leu Glu Asn Glu Gln Ser Gln Glu Asn Ser Ile Asn Pro 
65                  70                  75                  80  


Ile Gln Lys Glu Glu Asp Glu Gly Val Asp Leu Ser Glu Gly Ser Ser 
                85                  90                  95      


Asn Glu Asp Glu Asp Leu Gly Pro Cys Glu Gly Pro Ser Lys Glu Asp 
            100                 105                 110         


Lys Asp Leu Asp Ser Ser Glu Gly Ser Ser Gln Glu Asp Glu Asp Leu 
        115                 120                 125             


Gly Leu Ser Glu Gly Ser Ser Gln Asp Ser Gly Glu Asp 
    130                 135                 140     


<210>  103
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ser Thr Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln 
            20                  25                  30          


Lys Gly Thr Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
    50                  55                  60                  


Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Thr Leu His 
65                  70                  75                  80  


Asp Ile Phe Glu Asn Lys Thr Asp Val Val Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
            100                 105                 110         


Glu Asp Glu Ala Thr Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
        115                 120                 125             


Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys Leu Ile 
145                 150                 155                 160 


Asp Phe Gly Ile Ala His Lys Ile Glu Ala Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu 
    210                 215                 220                 


Thr Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His 
            260                 265                 270         


Ser Trp Ile Lys Ala Ile Arg Arg Arg Asn Val Arg Gly Glu Asp Ser 
        275                 280                 285             


Gly Arg Lys Pro Glu Arg Arg Arg Leu Lys Thr Thr Arg Leu Lys Glu 
    290                 295                 300                 


Tyr Thr Ile Lys Ser His Ser Ser Leu Pro Pro Asn Asn Ser Tyr Ala 
305                 310                 315                 320 


Asp Phe Glu Arg Phe Ser Lys Val Leu Glu Glu Ala Ala Ala Ala Glu 
                325                 330                 335     


Glu Gly Leu Arg Glu Leu Gln Arg Ser Arg Arg Leu Cys His Glu Asp 
            340                 345                 350         


Val Glu Ala Leu Ala Ala Ile Tyr Glu Glu Lys Glu Ala Trp Tyr Arg 
        355                 360                 365             


Glu Glu Ser Asp Ser Leu Gly Gln Asp Leu Arg Arg Leu Arg Gln Glu 
    370                 375                 380                 


Leu Leu Lys Thr Glu Ala Leu Lys Arg Gln Ala Gln Glu Glu Ala Lys 
385                 390                 395                 400 


Gly Ala Leu Leu Gly Thr Ser Gly Leu Lys Arg Arg Phe Ser Arg Leu 
                405                 410                 415     


Glu Asn Arg Tyr Glu Ala Leu Ala Lys Gln Val Ala Ser Glu Met Arg 
            420                 425                 430         


Phe Val Gln Asp Leu Val Arg Ala Leu Glu Gln Glu Lys Leu Gln Gly 
        435                 440                 445             


Val Glu Cys Gly Leu Arg 
    450                 


<210>  104
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn 
            100                 105                 110         


Asp Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Met Glu Arg 
305                 310                 315                 320 


Ala Met Leu Glu Asn Glu Lys Lys Lys Arg Glu Met Ala Glu Lys Glu 
                325                 330                 335     


Lys Glu Lys Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys 
            340                 345                 350         


Gln Ile Glu Glu Gln Thr Lys Lys Ala Gln Gln Glu Leu Glu Glu Gln 
        355                 360                 365             


Thr Arg Arg Ala Leu Glu Leu Glu Gln Glu Arg Lys Arg Ala Gln Ser 
    370                 375                 380                 


Glu Ala Glu Lys Leu Ala Lys Glu Arg Gln Glu Ala Glu Glu Ala Lys 
385                 390                 395                 400 


Glu Ala Leu Leu Gln Ala Ser Arg Asp Gln Lys Lys Thr Gln Glu Gln 
                405                 410                 415     


Leu Ala Leu Glu Met Ala Glu Leu Thr Ala Arg Ile Ser Gln Leu Glu 
            420                 425                 430         


Met Ala Arg Gln Lys Lys Glu Ser Glu Ala Val Glu Trp Gln Gln Lys 
        435                 440                 445             


Ala Gln Met Val Gln Glu Asp Leu Glu Lys Thr Arg Ala Glu Leu Lys 
    450                 455                 460                 


Thr Ala Met Ser Thr Pro His Val Ala Glu Pro Ala Glu Asn Glu Gln 
465                 470                 475                 480 


Asp Glu Gln Asp Glu Asn Gly Ala Glu Ala Ser Ala Asp Leu Arg Ala 
                485                 490                 495     


Asp Ala Met Ala Lys Asp Arg Ser Glu Glu Glu Arg Thr Thr Glu Ala 
            500                 505                 510         


Glu Lys Asn Glu Arg Val Gln Lys His Leu Lys Ala Leu Thr Ser Glu 
        515                 520                 525             


Leu Ala Asn Ala Arg Asp Glu Ser Lys Lys Thr Ala Asn Asp Met Ile 
    530                 535                 540                 


His Ala Glu Asn Met Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg 
545                 550                 555                 560 


Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser 
                565                 570                 575     


Met 
    


<210>  105
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Asp Asp Tyr Met Val Leu Arg Met Ile Gly Glu Gly Ser Phe Gly 
1               5                   10                  15      


Arg Ala Leu Leu Val Gln His Glu Ser Ser Asn Gln Met Phe Ala Met 
            20                  25                  30          


Lys Glu Ile Arg Leu Pro Lys Ser Phe Ser Asn Thr Gln Asn Ser Arg 
        35                  40                  45              


Lys Glu Ala Val Leu Leu Ala Lys Met Lys His Pro Asn Ile Val Ala 
    50                  55                  60                  


Phe Lys Glu Ser Phe Glu Ala Glu Gly His Leu Tyr Ile Val Met Glu 
65                  70                  75                  80  


Tyr Cys Asp Gly Gly Asp Leu Met Gln Lys Ile Lys Gln Gln Lys Gly 
                85                  90                  95      


Lys Leu Phe Pro Glu Asp Met Ile Leu Asn Trp Phe Thr Gln Met Cys 
            100                 105                 110         


Leu Gly Val Asn His Ile His Lys Lys Arg Val Leu His Arg Asp Ile 
        115                 120                 125             


Lys Ser Lys Asn Ile Phe Leu Thr Gln Asn Gly Lys Val Lys Leu Gly 
    130                 135                 140                 


Asp Phe Gly Ser Ala Arg Leu Leu Ser Asn Pro Met Ala Phe Ala Cys 
145                 150                 155                 160 


Thr Tyr Val Gly Thr Pro Tyr Tyr Val Pro Pro Glu Ile Trp Glu Asn 
                165                 170                 175     


Leu Pro Tyr Asn Asn Lys Ser Asp Ile Trp Ser Leu Gly Cys Ile Leu 
            180                 185                 190         


Tyr Glu Leu Cys Thr Leu Lys His Pro Phe Gln Ala Asn Ser Trp Lys 
        195                 200                 205             


Asn Leu Ile Leu Lys Val Cys Gln Gly Cys Ile Ser Pro Leu Pro Ser 
    210                 215                 220                 


His Tyr Ser Tyr Glu Leu Gln Phe Leu Val Lys Gln Met Phe Lys Arg 
225                 230                 235                 240 


Asn Pro Ser His Arg Pro Ser Ala Thr Thr Leu Leu Ser Arg Gly Ile 
                245                 250                 255     


Val Ala Arg Leu Val Gln Lys Cys Leu Pro Pro Glu Ile Ile Met Glu 
            260                 265                 270         


Tyr Gly Glu Glu Val Leu Glu Glu Ile Lys Asn Ser Lys His Asn Thr 
        275                 280                 285             


Pro Arg Lys Lys Thr Asn Pro Ser Arg Ile Arg Ile Ala Leu Gly Asn 
    290                 295                 300                 


Glu Ala Ser Thr Val Gln Glu Glu Glu Gln Asp Arg Lys Gly Ser His 
305                 310                 315                 320 


Thr Asp Leu Glu Ser Ile Asn Glu Asn Leu Val Glu Ser Ala Leu Arg 
                325                 330                 335     


Arg Val Asn Arg Glu Glu Lys Gly Asn Lys Ser Val His Leu Arg Lys 
            340                 345                 350         


Ala Ser Ser Pro Asn Leu His Arg Arg Gln Trp Glu Lys Asn Val Pro 
        355                 360                 365             


Asn Thr Ala Leu Thr Ala Leu Glu Asn Ala Ser Ile Leu Thr Ser Ser 
    370                 375                 380                 


Leu Thr Ala Glu Asp Asp Arg Gly Gly Ser Val Ile Lys Tyr Ser Lys 
385                 390                 395                 400 


Asn Thr Thr Arg Lys Gln Trp Leu Lys Glu Thr Pro Asp Thr Leu Leu 
                405                 410                 415     


Asn Ile Leu Lys Asn Ala Asp Leu Ser Leu Ala Phe Gln Thr Tyr Thr 
            420                 425                 430         


Ile Tyr Arg Pro Gly Ser Glu Gly Phe Leu Lys Gly Pro Leu Ser Glu 
        435                 440                 445             


Glu Thr Glu Ala Ser Asp Ser Val Asp Gly Gly His Asp Ser Val Ile 
    450                 455                 460                 


Leu Asp Pro Glu Arg Leu Glu Pro Gly Leu Asp Glu Glu Asp Thr Asp 
465                 470                 475                 480 


Phe Glu Glu Glu Asp Asp Asn Pro Asp Trp Val Ser Glu Leu Lys Lys 
                485                 490                 495     


Arg Ala Gly Trp Gln Gly Leu Cys Asp Arg 
            500                 505     


<210>  106
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ala Ser Ala Ala Arg Leu Thr Met Met Trp Glu Glu Val Thr Cys 
1               5                   10                  15      


Pro Ile Cys Leu Asp Pro Phe Val Glu Pro Val Ser Ile Glu Cys Gly 
            20                  25                  30          


His Ser Phe Cys Gln Glu Cys Ile Ser Gln Val Gly Lys Gly Gly Gly 
        35                  40                  45              


Ser Val Cys Pro Val Cys Arg Gln Arg Phe Leu Leu Lys Asn Leu Arg 
    50                  55                  60                  


Pro Asn Arg Gln Leu Ala Asn Met Val Asn Asn Leu Lys Glu Ile Ser 
65                  70                  75                  80  


Gln Glu Ala Arg Glu Gly Thr Gln Gly Glu Arg Cys Ala Val His Gly 
                85                  90                  95      


Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys Ala Leu Cys Trp 
            100                 105                 110         


Val Cys Ala Gln Ser Arg Lys His Arg Asp His Ala Met Val Pro Leu 
        115                 120                 125             


Glu Glu Ala Ala Gln Glu Tyr Gln Glu Lys Leu Gln Val Ala Leu Gly 
    130                 135                 140                 


Glu Leu Arg Arg Lys Gln Glu Leu Ala Glu Lys Leu Glu Val Glu Ile 
145                 150                 155                 160 


Ala Ile Lys Arg Ala Asp Trp Lys Lys Thr Val Glu Thr Gln Lys Ser 
                165                 170                 175     


Arg Ile His Ala Glu Phe Val Gln Gln Lys Asn Phe Leu Val Glu Glu 
            180                 185                 190         


Glu Gln Arg Gln Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu 
        195                 200                 205             


Arg Ile Leu Gly Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala 
    210                 215                 220                 


Leu Gln Glu Leu Ile Ser Glu Leu Asp Arg Arg Cys His Ser Ser Ala 
225                 230                 235                 240 


Leu Glu Leu Leu Gln Glu Val Ile Ile Val Leu Glu Arg Ser Glu Ser 
                245                 250                 255     


Trp Asn Leu Lys Asp Leu Asp Ile Thr Ser Pro Glu Leu Arg Ser Val 
            260                 265                 270         


Cys His Val Pro Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His 
        275                 280                 285             


Ile Thr Leu Asp Pro Asp Thr Ala Asn Pro Trp Leu Ile Leu Ser Glu 
    290                 295                 300                 


Asp Arg Arg Gln Val Arg Leu Gly Asp Thr Gln Gln Ser Ile Pro Gly 
305                 310                 315                 320 


Asn Glu Glu Arg Phe Asp Ser Tyr Pro Met Val Leu Gly Ala Gln His 
                325                 330                 335     


Phe His Ser Gly Lys His Tyr Trp Glu Val Asp Val Thr Gly Lys Glu 
            340                 345                 350         


Ala Trp Asp Leu Gly Val Cys Arg Asp Ser Val Arg Arg Lys Gly His 
        355                 360                 365             


Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile Trp Leu Trp Asn 
    370                 375                 380                 


Lys Gln Lys Tyr Glu Ala Gly Thr Tyr Pro Gln Thr Pro Leu His Leu 
385                 390                 395                 400 


Gln Val Pro Pro Cys Gln Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly 
                405                 410                 415     


Met Val Ser Phe Tyr Asn Ile Thr Asp His Gly Ser Leu Ile Tyr Ser 
            420                 425                 430         


Phe Ser Glu Cys Ala Phe Thr Gly Pro Leu Arg Pro Phe Phe Ser Pro 
        435                 440                 445             


Gly Phe Asn Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr Leu Cys Pro 
    450                 455                 460                 


Leu Asn Ile Gly Ser Gln Gly Ser Thr Asp Tyr 
465                 470                 475 


<210>  107
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Asp Pro Ala Ala Ser Ser Cys Met Arg Ser Leu Gln Pro Pro Ala 
1               5                   10                  15      


Pro Val Trp Gly Cys Leu Arg Asn Pro His Ser Glu Gly Asn Gly Ala 
            20                  25                  30          


Ser Gly Leu Pro His Tyr Pro Pro Thr Pro Phe Ser Phe His Gln Lys 
        35                  40                  45              


Pro Asp Phe Leu Ala Thr Ala Thr Ala Ala Tyr Pro Asp Phe Ser Ala 
    50                  55                  60                  


Ser Cys Leu Ala Ala Thr Pro His Ser Leu Pro Gln Glu Glu His Ile 
65                  70                  75                  80  


Phe Thr Glu Gln His Pro Ala Phe Pro Gln Ser Pro Asn Trp His Phe 
                85                  90                  95      


Pro Val Ser Asp Ala Arg Arg Arg Pro Asn Ser Gly Pro Ala Gly Gly 
            100                 105                 110         


Ser Lys Glu Met Gly Thr Ser Ser Leu Gly Leu Val Asp Thr Thr Gly 
        115                 120                 125             


Gly Pro Gly Asp Asp Tyr Gly Val Leu Gly Ser Thr Ala Asn Glu Thr 
    130                 135                 140                 


Glu Lys Lys Ser Ser Arg Arg Arg Lys Glu Ser Ser Asp Asn Gln Glu 
145                 150                 155                 160 


Asn Arg Gly Lys Pro Glu Gly Ser Ser Lys Ala Arg Lys Glu Arg Thr 
                165                 170                 175     


Ala Phe Thr Lys Glu Gln Leu Arg Glu Leu Glu Ala Glu Phe Ala His 
            180                 185                 190         


His Asn Tyr Leu Thr Arg Leu Arg Arg Tyr Glu Ile Ala Val Asn Leu 
        195                 200                 205             


Asp Leu Ser Glu Arg Gln Val Lys Val Trp Phe Gln Asn Arg Arg Met 
    210                 215                 220                 


Lys Trp Lys Arg Val Lys Gly Gly Gln Pro Ile Ser Pro Asn Gly Gln 
225                 230                 235                 240 


Asp Pro Glu Asp Gly Asp Ser Thr Ala Ser Pro Ser Ser Glu 
                245                 250                 


<210>  108
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  108

Glu Gln Gly Leu Glu Glu Glu Glu Glu Val Asp Pro Arg Ile Gln Gly 
1               5                   10                  15      


Glu Leu Glu Lys Leu Asn Gln Ser Thr Asp Asp Ile Asn Arg Arg Glu 
            20                  25                  30          


Thr Glu Leu Glu Asp Ala Arg Gln Lys Phe Arg Ser Val Leu Val Glu 
        35                  40                  45              


Ala Thr Val Lys Leu Asp Glu Leu Val Lys Lys Ile Gly Lys Ala Val 
    50                  55                  60                  


Glu Asp Ser Lys Pro Tyr Trp Glu Ala Arg Arg Val Ala Arg Gln Ala 
65                  70                  75                  80  


Gln Leu Glu Ala Gln Lys Ala Thr Gln Asp Phe Gln Arg Ala Thr Glu 
                85                  90                  95      


Val Leu Arg Ala Ala Lys Glu Thr Ile Ser Leu Ala Glu Gln Arg Leu 
            100                 105                 110         


Leu Glu Asp Asp Lys Arg Gln Phe Asp Ser Ala Trp Gln Glu Met Leu 
        115                 120                 125             


Asn His Ala Thr Gln Arg Val Met Glu Ala Glu Gln Thr Lys Thr Arg 
    130                 135                 140                 


Ser Glu Leu Val His Lys Glu Thr Ala Ala Arg Tyr Asn Ala Ala Met 
145                 150                 155                 160 


Gly Arg Met Arg Gln Leu Glu Lys Lys Leu Lys Arg Ala Ile Asn Lys 
                165                 170                 175     


Ser Lys Pro Tyr Phe Glu Leu Lys Ala Lys Tyr Tyr Val Gln Leu Glu 
            180                 185                 190         


Gln Leu Lys Lys Thr Val Asp Asp Leu Gln Ala Lys Leu Thr Leu Ala 
        195                 200                 205             


Lys Gly Glu Tyr Lys Met Ala Leu Lys Asn Leu Glu Met Ile Ser Asp 
    210                 215                 220                 


Glu Ile His Glu Arg Arg Arg Ser Ser Ala Met Gly Pro Arg Gly Cys 
225                 230                 235                 240 


Gly Val Gly Ala Glu Gly Ser Ser Thr Ser Val Glu Asp Leu Pro Gly 
                245                 250                 255     


Ser Lys Pro Glu Pro Asp Ala Ile Ser Val Ala Ser Glu Ala Phe Glu 
            260                 265                 270         


Asp Asp Ser Cys Ser Asn Phe Val Ser Glu Asp Asp Ser Glu Thr Gln 
        275                 280                 285             


Ser Val Ser Ser Phe Ser Ser Gly Pro Thr Ser Pro Ser Glu Met Pro 
    290                 295                 300                 


Asp Gln Phe Pro Ala Val Val Arg Pro Gly Ser Leu Asp Leu Pro Ser 
305                 310                 315                 320 


Pro Val Ser Leu Ser Glu Phe Gly Met Met Phe Pro Val Leu Gly Pro 
                325                 330                 335     


Arg Ser Glu Cys Ser Gly Ala Ser Ser Pro Glu Cys Glu Val Glu Arg 
            340                 345                 350         


Gly Asp Arg Ala Glu Gly Ala Glu Asn Lys Thr Ser Asp Lys Ala Asn 
        355                 360                 365             


Asn Asn Arg Gly Leu Ser Ser Ser Ser Gly Ser Gly Gly Ser Ser Lys 
    370                 375                 380                 


Ser Gln Ser Ser Thr Ser Pro Glu Gly Gln Ala Leu Glu Asn Arg Met 
385                 390                 395                 400 


Lys Gln Leu Ser Leu Gln Cys Ser Lys Gly Arg Asp Gly Ile Ile Ala 
                405                 410                 415     


Asp Ile Lys Met Val Gln Ile Gly 
            420                 


<210>  109
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Leu Ala Val His Phe Asp Lys Pro Gly Gly Pro Glu Asn Leu Tyr 
1               5                   10                  15      


Val Lys Glu Val Ala Lys Pro Ser Pro Gly Glu Gly Glu Val Leu Leu 
            20                  25                  30          


Lys Val Ala Ala Ser Ala Leu Asn Arg Ala Asp Leu Met Gln Arg Gln 
        35                  40                  45              


Gly Gln Tyr Asp Pro Pro Pro Gly Ala Ser Asn Ile Leu Gly Leu Glu 
    50                  55                  60                  


Ala Ser Gly His Val Ala Glu Leu Gly Pro Gly Cys Gln Gly His Trp 
65                  70                  75                  80  


Lys Ile Gly Asp Thr Ala Met Ala Leu Leu Pro Gly Gly Gly Gln Ala 
                85                  90                  95      


Gln Tyr Val Thr Val Pro Glu Gly Leu Leu Met Pro Ile Pro Glu Gly 
            100                 105                 110         


Leu Thr Leu Thr Gln Ala Ala Ala Ile Pro Glu Ala Trp Leu Thr Ala 
        115                 120                 125             


Phe Gln Leu Leu His Leu Val Gly Asn Val Gln Ala Gly Asp Tyr Val 
    130                 135                 140                 


Leu Ile His Ala Gly Leu Ser Gly Val Gly Thr Ala Ala Ile Gln Leu 
145                 150                 155                 160 


Thr Arg Met Ala Gly Ala Ile Pro Leu Val Thr Ala Gly Ser Gln Lys 
                165                 170                 175     


Lys Leu Gln Met Ala Glu Lys Leu Gly Ala Ala Ala Gly Phe Asn Tyr 
            180                 185                 190         


Lys Lys Glu Asp Phe Ser Glu Ala Thr Leu Lys Phe Thr Lys Gly Ala 
        195                 200                 205             


Gly Val Asn Leu Ile Leu Asp Cys Ile Gly Gly Ser Tyr Trp Glu Lys 
    210                 215                 220                 


Asn Val Asn Cys Leu Ala Leu Asp Gly Arg Trp Val Leu Tyr Gly Leu 
225                 230                 235                 240 


Met Gly Gly Gly Asp Ile Asn Gly Pro Leu Phe Ser Lys Leu Leu Phe 
                245                 250                 255     


Lys Arg Gly Ser Leu Ile Thr Ser Leu Leu Arg Ser Arg Asp Asn Lys 
            260                 265                 270         


Tyr Lys Gln Met Leu Val Asn Ala Phe Thr Glu Gln Ile Leu Pro His 
        275                 280                 285             


Phe Ser Thr Glu Gly Pro Gln Arg Leu Leu Pro Val Leu Asp Arg Ile 
    290                 295                 300                 


Tyr Pro Val Thr Glu Ile Gln Glu Ala His Ser Thr Trp Arg Pro Thr 
305                 310                 315                 320 


Arg Thr 
        


<210>  110
<211>  1094
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Asn Val Asn Gln Ser Val Pro Pro Val Pro Pro Phe Gly Gln Pro 
1               5                   10                  15      


Gln Pro Ile Tyr Pro Gly Tyr His Gln Ser Ser Tyr Gly Gly Gln Ser 
            20                  25                  30          


Gly Ser Thr Ala Pro Ala Ile Pro Tyr Gly Ala Tyr Asn Gly Pro Val 
        35                  40                  45              


Pro Gly Tyr Gln Gln Thr Pro Pro Gln Gly Met Ser Arg Ala Pro Pro 
    50                  55                  60                  


Ser Ser Gly Ala Pro Pro Ala Ser Thr Ala Gln Ala Pro Cys Gly Gln 
65                  70                  75                  80  


Ala Ala Tyr Gly Gln Phe Gly Gln Gly Asp Val Gln Asn Gly Pro Ser 
                85                  90                  95      


Ser Thr Val Gln Met Gln Arg Leu Pro Gly Ser Gln Pro Phe Gly Ser 
            100                 105                 110         


Pro Leu Ala Pro Val Gly Asn Gln Pro Pro Val Leu Gln Pro Tyr Gly 
        115                 120                 125             


Pro Pro Pro Thr Ser Ala Gln Val Ala Thr Gln Leu Ser Gly Met Gln 
    130                 135                 140                 


Ile Ser Gly Ala Val Ala Pro Ala Pro Pro Ser Ser Gly Leu Gly Phe 
145                 150                 155                 160 


Gly Pro Pro Thr Ser Leu Ala Ser Ala Ser Gly Ser Phe Pro Asn Ser 
                165                 170                 175     


Gly Leu Tyr Gly Ser Tyr Pro Gln Gly Gln Ala Pro Pro Leu Ser Gln 
            180                 185                 190         


Ala Gln Gly His Pro Gly Ile Gln Thr Pro Gln Arg Ser Ala Pro Ser 
        195                 200                 205             


Gln Ala Ser Ser Phe Thr Pro Pro Ala Ser Gly Gly Pro Arg Leu Pro 
    210                 215                 220                 


Ser Met Thr Gly Pro Leu Leu Pro Gly Gln Ser Phe Gly Gly Pro Ser 
225                 230                 235                 240 


Val Ser Gln Pro Asn His Val Ser Ser Pro Pro Gln Ala Leu Pro Pro 
                245                 250                 255     


Gly Thr Gln Met Thr Gly Pro Leu Gly Pro Leu Pro Pro Met His Ser 
            260                 265                 270         


Pro Gln Gln Pro Gly Tyr Gln Pro Gln Gln Asn Gly Ser Phe Gly Pro 
        275                 280                 285             


Ala Arg Gly Pro Gln Ser Asn Tyr Gly Gly Pro Tyr Pro Ala Ala Pro 
    290                 295                 300                 


Thr Phe Gly Ser Gln Pro Gly Pro Pro Gln Pro Leu Pro Pro Lys Arg 
305                 310                 315                 320 


Leu Asp Pro Asp Ala Ile Pro Ser Pro Ile Gln Val Ile Glu Asp Asp 
                325                 330                 335     


Arg Asn Asn Arg Gly Thr Glu Pro Phe Val Thr Gly Val Arg Gly Gln 
            340                 345                 350         


Val Pro Pro Leu Val Thr Thr Asn Phe Leu Val Lys Asp Gln Gly Asn 
        355                 360                 365             


Ala Ser Pro Arg Tyr Ile Arg Cys Thr Ser Tyr Asn Ile Pro Cys Thr 
    370                 375                 380                 


Ser Asp Met Ala Lys Gln Ala Gln Val Pro Leu Ala Ala Val Ile Lys 
385                 390                 395                 400 


Pro Leu Ala Arg Leu Pro Pro Glu Glu Ala Ser Pro Tyr Val Val Asp 
                405                 410                 415     


His Gly Glu Ser Gly Pro Leu Arg Cys Asn Arg Cys Lys Ala Tyr Met 
            420                 425                 430         


Cys Pro Phe Met Gln Phe Ile Glu Gly Gly Arg Arg Phe Gln Cys Cys 
        435                 440                 445             


Phe Cys Ser Cys Ile Asn Asp Val Pro Pro Gln Tyr Phe Gln His Leu 
    450                 455                 460                 


Asp His Thr Gly Lys Arg Val Asp Ala Tyr Asp Arg Pro Glu Leu Ser 
465                 470                 475                 480 


Leu Gly Ser Tyr Glu Phe Leu Ala Thr Val Asp Tyr Cys Lys Asn Asn 
                485                 490                 495     


Lys Phe Pro Ser Pro Pro Ala Phe Ile Phe Met Ile Asp Val Ser Tyr 
            500                 505                 510         


Asn Ala Ile Arg Thr Gly Leu Val Arg Leu Leu Cys Glu Glu Leu Lys 
        515                 520                 525             


Ser Leu Leu Asp Phe Leu Pro Arg Glu Gly Gly Ala Glu Glu Ser Ala 
    530                 535                 540                 


Ile Arg Val Gly Phe Val Thr Tyr Asn Lys Val Leu His Phe Tyr Asn 
545                 550                 555                 560 


Val Lys Ser Ser Leu Ala Gln Pro Gln Met Met Val Val Ser Asp Val 
                565                 570                 575     


Ala Asp Met Phe Val Pro Leu Leu Asp Gly Phe Leu Val Asn Val Asn 
            580                 585                 590         


Glu Ser Arg Ala Val Ile Thr Ser Leu Leu Asp Gln Ile Pro Glu Met 
        595                 600                 605             


Phe Ala Asp Thr Arg Glu Thr Glu Thr Val Phe Val Pro Val Ile Gln 
    610                 615                 620                 


Ala Gly Met Glu Ala Leu Lys Ala Ala Glu Cys Ala Gly Lys Leu Phe 
625                 630                 635                 640 


Leu Phe His Thr Ser Leu Pro Ile Ala Glu Ala Pro Gly Lys Leu Lys 
                645                 650                 655     


Asn Arg Asp Asp Arg Lys Leu Ile Asn Thr Asp Lys Glu Lys Thr Leu 
            660                 665                 670         


Phe Gln Pro Gln Thr Gly Ala Tyr Gln Thr Leu Ala Lys Glu Cys Val 
        675                 680                 685             


Ala Gln Gly Cys Cys Val Asp Leu Phe Leu Phe Pro Asn Gln Tyr Val 
    690                 695                 700                 


Asp Val Ala Thr Leu Ser Val Val Pro Gln Leu Thr Gly Gly Ser Val 
705                 710                 715                 720 


Tyr Lys Tyr Ala Ser Phe Gln Val Glu Asn Asp Gln Glu Arg Phe Leu 
                725                 730                 735     


Ser Asp Leu Arg Arg Asp Val Gln Lys Val Val Gly Phe Asp Ala Val 
            740                 745                 750         


Met Arg Val Arg Thr Ser Thr Gly Ile Arg Ala Val Asp Phe Phe Gly 
        755                 760                 765             


Ala Phe Tyr Met Ser Asn Thr Thr Asp Val Glu Leu Ala Gly Leu Asp 
    770                 775                 780                 


Gly Asp Lys Thr Val Thr Val Glu Phe Lys His Asp Asp Arg Leu Asn 
785                 790                 795                 800 


Glu Glu Ser Gly Ala Leu Leu Gln Cys Ala Leu Leu Tyr Thr Ser Cys 
                805                 810                 815     


Ala Gly Gln Arg Arg Leu Arg Ile His Asn Leu Ala Leu Asn Cys Cys 
            820                 825                 830         


Thr Gln Leu Ala Asp Leu Tyr Arg Asn Cys Glu Thr Asp Thr Leu Ile 
        835                 840                 845             


Asn Tyr Met Ala Lys Phe Ala Tyr Arg Gly Val Leu Asn Ser Pro Val 
    850                 855                 860                 


Lys Ala Val Arg Asp Thr Leu Ile Thr Gln Cys Ala Gln Ile Leu Ala 
865                 870                 875                 880 


Cys Tyr Arg Lys Asn Cys Ala Ser Pro Ser Ser Ala Gly Gln Leu Ile 
                885                 890                 895     


Leu Pro Glu Cys Met Lys Leu Leu Pro Val Tyr Leu Asn Cys Val Leu 
            900                 905                 910         


Lys Ser Asp Val Leu Gln Pro Gly Ala Glu Val Thr Thr Asp Asp Arg 
        915                 920                 925             


Ala Tyr Val Arg Gln Leu Val Thr Ser Met Asp Val Thr Glu Thr Asn 
    930                 935                 940                 


Val Phe Phe Tyr Pro Arg Leu Leu Pro Leu Thr Lys Ser Pro Val Glu 
945                 950                 955                 960 


Ser Thr Thr Glu Pro Pro Ala Val Arg Ala Ser Glu Glu Arg Leu Ser 
                965                 970                 975     


Asn Gly Asp Ile Tyr Leu Leu Glu Asn Gly Leu Asn Leu Phe Leu Trp 
            980                 985                 990         


Val Gly Ala Ser Val Gln Gln Gly  Val Val Gln Ser Leu  Phe Ser Val 
        995                 1000                 1005             


Ser Ser  Phe Ser Gln Ile Thr  Ser Gly Leu Ser Val  Leu Pro Val 
    1010                 1015                 1020             


Leu Asp  Asn Pro Leu Ser Lys  Lys Val Arg Gly Leu  Ile Asp Ser 
    1025                 1030                 1035             


Leu Arg  Ala Gln Arg Ser Arg  Tyr Met Lys Leu Thr  Val Val Lys 
    1040                 1045                 1050             


Gln Glu  Asp Lys Met Glu Met  Leu Phe Lys His Phe  Leu Val Glu 
    1055                 1060                 1065             


Asp Lys  Ser Leu Ser Gly Gly  Ala Ser Tyr Val Asp  Phe Leu Cys 
    1070                 1075                 1080             


His Met  His Lys Glu Ile Arg  Gln Leu Leu Ser 
    1085                 1090                 


<210>  111
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
1               5                   10                  15      


Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
            20                  25                  30          


Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
        35                  40                  45              


Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
    50                  55                  60                  


Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
65                  70                  75                  80  


Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                85                  90                  95      


Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
            100                 105                 110         


Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
        115                 120                 125             


Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
    130                 135                 140                 


Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
145                 150                 155                 160 


Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                165                 170                 175     


Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
            180                 185                 190         


Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
        195                 200                 205             


His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
    210                 215                 220                 


Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
225                 230                 235                 240 


Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                245                 250                 255     


Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
            260                 265                 270         


Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
        275                 280                 285             


Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
    290                 295                 300                 


Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
305                 310                 315                 320 


Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                325                 330                 335     


Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
            340                 345                 350         


Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
        355                 360                 365             


Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
    370                 375                 380                 


Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
385                 390                 395                 400 


Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                405                 410                 415     


Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
            420                 425                 430         


Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
        435                 440                 445             


Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
    450                 455                 460                 


Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
465                 470                 475                 480 


Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                485                 490                 495     


Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
            500                 505                 510         


Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
        515                 520                 525             


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
    530                 535                 540                 


His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
545                 550                 555                 560 


Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                565                 570                 575     


Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
            580                 585                 590         


Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
        595                 600                 605             


Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
    610                 615                 620                 


Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
625                 630                 635                 640 


Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                645                 650                 655     


Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
            660                 665                 670         


Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
        675                 680                 685             


Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
    690                 695                 700                 


Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
705                 710                 715                 720 


Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                725                 730                 735     


Pro 
    


<210>  112
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Lys Tyr Lys Asn Leu Met Ala Arg Ala Leu Tyr Asp Asn Val Pro 
1               5                   10                  15      


Glu Cys Ala Glu Glu Leu Ala Phe Arg Lys Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Ile Glu Gln Asn Thr Gly Gly Leu Glu Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Val Lys Leu Leu Ile 
    50                  55                  60                  


Gly Pro Met Gln Glu Thr Ala Ser Ser His Glu Gln Pro Ala Ser Gly 
65                  70                  75                  80  


Leu Met Gln Gln Thr Phe Gly Gln Gln Lys Leu Tyr Gln Val Pro Asn 
                85                  90                  95      


Pro Gln Ala Ala Pro Arg Asp Thr Ile Tyr Gln Val Pro Pro Ser Tyr 
            100                 105                 110         


Gln Asn Gln Gly Ile Tyr Gln Val Pro Thr Gly His Gly Thr Gln Glu 
        115                 120                 125             


Gln Glu Val Tyr Gln Val Pro Pro Ser Val Gln Arg Ser Ile Gly Gly 
    130                 135                 140                 


Thr Ser Gly Pro His Val Gly Lys Lys Val Ile Thr Pro Val Arg Thr 
145                 150                 155                 160 


Gly His Gly Tyr Val Tyr Glu Tyr Pro Ser Arg Tyr Gln Lys Asp Val 
                165                 170                 175     


Tyr Asp Ile Pro Pro Ser His Thr Thr Gln Gly Val Tyr Asp Ile Pro 
            180                 185                 190         


Pro Ser Ser Ala Lys Gly Pro Val Phe Ser Val Pro Val Gly Glu Ile 
        195                 200                 205             


Lys Pro Gln Gly Val Tyr Asp Ile Pro Pro Thr Lys Gly Val Tyr Ala 
    210                 215                 220                 


Ile Pro Pro Ser Ala Cys Arg Asp Glu Ala Gly Leu Arg Glu Lys Asp 
225                 230                 235                 240 


Tyr Asp Phe Pro Pro Pro Met Arg Gln Ala Gly Arg Pro Asp Leu Arg 
                245                 250                 255     


Pro Glu Gly Val Tyr Asp Ile Pro Pro Thr Cys Thr Lys Pro Ala Gly 
            260                 265                 270         


Lys Asp Leu His Val Lys Tyr Asn Cys Asp Ile Pro Gly Ala Ala Glu 
        275                 280                 285             


Pro Val Ala Arg Arg His Gln Ser Leu Ser Pro Asn His Pro Pro Pro 
    290                 295                 300                 


Gln Leu Gly Gln Ser Val Gly Ser Gln Asn Asp Ala Tyr Asp Val Pro 
305                 310                 315                 320 


Arg Gly Val Gln Phe Leu Glu Pro Pro Ala Glu Thr Ser Glu Lys Ala 
                325                 330                 335     


Asn Pro Gln Glu Arg Asp Gly Val Tyr Asp Val Pro Leu His Asn Pro 
            340                 345                 350         


Pro Asp Ala Lys Gly Ser Arg Asp Leu Val Asp Gly Ile Asn Arg Leu 
        355                 360                 365             


Ser Phe Ser Ser Thr Gly Ser Thr Arg Ser Asn Met Ser Thr Ser Ser 
    370                 375                 380                 


Thr Ser Ser Lys Glu Ser Ser Leu Ser Ala Ser Pro Ala Gln Asp Lys 
385                 390                 395                 400 


Arg Leu Phe Leu Asp Pro Asp Thr Ala Ile Glu Arg Leu Gln Arg Leu 
                405                 410                 415     


Gln Gln Ala Leu Glu Met Gly Val Ser Ser Leu Met Ala Leu Val Thr 
            420                 425                 430         


Thr Asp Trp Arg Cys Tyr Gly Tyr Met Glu Arg His Ile Asn Glu Ile 
        435                 440                 445             


Arg Thr Ala Val Asp Lys Val Glu Leu Phe Leu Lys Glu Tyr Leu His 
    450                 455                 460                 


Phe Val Lys Gly Ala Val Ala Asn Ala Ala Cys Leu Pro Glu Leu Ile 
465                 470                 475                 480 


Leu His Asn Lys Met Lys Arg Glu Leu Gln Arg Val Glu Asp Ser His 
                485                 490                 495     


Gln Ile Leu Ser Gln Thr Ser His Asp Leu Asn Glu Cys Ser Trp Ser 
            500                 505                 510         


Leu Asn Ile Leu Ala Ile Asn Lys Pro Gln Asn Lys Cys Asp Asp Leu 
        515                 520                 525             


Asp Arg Phe Val Met Val Ala Lys Thr Val Pro Asp Asp Ala Lys Gln 
    530                 535                 540                 


Leu Thr Thr Thr Ile Asn Thr Asn Ala Glu Ala Leu Phe Arg Pro Gly 
545                 550                 555                 560 


Pro Gly Ser Leu His Leu Lys Asn Gly Pro Glu Ser Ile Met Asn Ser 
                565                 570                 575     


Thr Glu Tyr Pro His Gly Gly Ser Gln Gly Gln Leu Leu His Pro Gly 
            580                 585                 590         


Asp His Lys Ala Gln Ala His Asn Lys Ala Leu Pro Pro Gly Leu Ser 
        595                 600                 605             


Lys Glu Gln Ala Pro Asp Cys Ser Ser Ser Asp Gly Ser Glu Arg Ser 
    610                 615                 620                 


Trp Met Asp Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu Phe 
625                 630                 635                 640 


Glu Arg Gln Gln Lys Glu Leu Leu Glu Lys Glu Asn Ile Met Lys Gln 
                645                 650                 655     


Asn Lys Met Gln Leu Glu His His Gln Leu Ser Gln Phe Gln Leu Leu 
            660                 665                 670         


Glu Gln Glu Ile Thr Lys Pro Val Glu Asn Asp Ile Ser Lys Trp Lys 
        675                 680                 685             


Pro Ser Gln Ser Leu Pro Thr Thr Asn Ser Gly Val Ser Ala Gln Asp 
    690                 695                 700                 


Arg Gln Leu Leu Cys Phe Tyr Tyr Asp Gln Cys Glu Thr His Phe Ile 
705                 710                 715                 720 


Ser Leu Leu Asn Ala Ile Asp Ala Leu Phe Ser Cys Val Ser Ser Ala 
                725                 730                 735     


Gln Pro Pro Arg Ile Phe Val Ala His Ser Lys Phe Val Ile Leu Ser 
            740                 745                 750         


Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Thr Arg Gln Val Thr 
        755                 760                 765             


Ala Gln Asp Ile Arg Asn Lys Val Met Asn Ser Ser Asn Gln Leu Cys 
    770                 775                 780                 


Glu Gln Leu Lys Thr Ile Val Met Ala Thr Lys Met Ala Ala Leu His 
785                 790                 795                 800 


Tyr Pro Ser Thr Thr Ala Leu Gln Glu Met Val His Gln Val Thr Asp 
                805                 810                 815     


Leu Ser Arg Asn Ala Gln Leu Phe Lys Arg Ser Leu Leu Glu Met Ala 
            820                 825                 830         


Thr Phe 
        


<210>  113
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Thr Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Thr Ala His Glu Thr Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro Arg Gly 
            100                 105                 110         


Phe Ala Arg Gly Leu Glu Pro Glu Arg Ile Ile Gly Ala Thr Asp Ser 
        115                 120                 125             


Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asn Ser Asp Glu Ala 
    130                 135                 140                 


Asp Leu Val Pro Ala Lys Glu Ala Asn Val Lys Cys Pro Gln Val Val 
145                 150                 155                 160 


Ile Ser Phe Tyr Glu Glu Arg Leu Thr Trp His Ser Tyr Pro Ser Glu 
                165                 170                 175     


Asp Asp Asp Lys Lys Asp Asp Lys Asn 
            180                 185 


<210>  114
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ser Thr Arg Glu Ser Phe Asn Pro Glu Ser Tyr Glu Leu Asp Lys 
1               5                   10                  15      


Ser Phe Arg Leu Thr Arg Phe Thr Glu Leu Lys Gly Thr Gly Cys Lys 
            20                  25                  30          


Val Pro Gln Asp Val Leu Gln Lys Leu Leu Glu Ser Leu Gln Glu Asn 
        35                  40                  45              


His Phe Gln Glu Asp Glu Gln Phe Leu Gly Ala Val Met Pro Arg Leu 
    50                  55                  60                  


Gly Ile Gly Met Asp Thr Cys Val Ile Pro Leu Arg His Gly Gly Leu 
65                  70                  75                  80  


Ser Leu Val Gln Thr Thr Asp Tyr Ile Tyr Pro Ile Val Asp Asp Pro 
                85                  90                  95      


Tyr Met Met Gly Arg Ile Ala Cys Ala Asn Val Leu Ser Asp Leu Tyr 
            100                 105                 110         


Ala Met Gly Val Thr Glu Cys Asp Asn Met Leu Met Leu Leu Gly Val 
        115                 120                 125             


Ser Asn Lys Met Thr Asp Arg Glu Arg Asp Lys Val Met Pro Leu Ile 
    130                 135                 140                 


Ile Gln Gly Phe Lys Asp Ala Ala Glu Glu Ala Gly Thr Ser Val Thr 
145                 150                 155                 160 


Gly Gly Gln Thr Val Leu Asn Pro Trp Ile Val Leu Gly Gly Val Ala 
                165                 170                 175     


Thr Thr Val Cys Gln Pro Asn Glu Phe Ile Met Pro Asp Asn Ala Val 
            180                 185                 190         


Pro Gly Asp Val Leu Val Leu Thr Lys Pro Leu Gly Thr Gln Val Ala 
        195                 200                 205             


Val Ala Val His Gln Trp Leu Asp Ile Pro Glu Lys Trp Asn Lys Ile 
    210                 215                 220                 


Lys Leu Val Val Thr Gln Glu Asp Val Glu Leu Ala Tyr Gln Glu Ala 
225                 230                 235                 240 


Met Met Asn Met Ala Arg Leu Asn Arg Thr Ala Ala Gly Leu Met His 
                245                 250                 255     


Thr Phe Asn Ala His Ala Ala Thr Asp Ile Thr Gly Phe Gly Ile Leu 
            260                 265                 270         


Gly His Ala Gln Asn Leu Ala Lys Gln Gln Arg Asn Glu Val Ser Phe 
        275                 280                 285             


Val Ile His Asn Leu Pro Val Leu Ala Lys Met Ala Ala Val Ser Lys 
    290                 295                 300                 


Ala Cys Gly Asn Met Phe Gly Leu Met His Gly Thr Cys Pro Glu Thr 
305                 310                 315                 320 


Ser Gly Gly Leu Leu Ile Cys Leu Pro Arg Glu Gln Ala Ala Arg Phe 
                325                 330                 335     


Cys Ala Glu Ile Lys Ser Pro Lys Tyr Gly Glu Gly His Gln Ala Trp 
            340                 345                 350         


Ile Ile Gly Ile Val Glu Lys Gly Asn Arg Thr Ala Arg Ile Ile Asp 
        355                 360                 365             


Lys Pro Arg Ile Ile Glu Val Ala Pro Gln Val Ala Thr Gln Asn Val 
    370                 375                 380                 


Asn Pro Thr Pro Gly Ala Thr Ser 
385                 390         


<210>  115
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ala Val Asn Val Tyr Ser Thr Ser Val Thr Ser Asp Asn Leu Ser 
1               5                   10                  15      


Arg His Asp Met Leu Ala Trp Ile Asn Glu Ser Leu Gln Leu Asn Leu 
            20                  25                  30          


Thr Lys Ile Glu Gln Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met 
        35                  40                  45              


Asp Met Leu Phe Pro Gly Ser Ile Ala Leu Lys Lys Val Lys Phe Gln 
    50                  55                  60                  


Ala Lys Leu Glu His Glu Tyr Ile Gln Asn Phe Lys Ile Leu Gln Ala 
65                  70                  75                  80  


Gly Phe Lys Arg Met Gly Val Asp Lys Ile Ile Pro Val Asp Lys Leu 
                85                  90                  95      


Val Lys Gly Lys Phe Gln Asp Asn Phe Glu Phe Val Gln Trp Phe Lys 
            100                 105                 110         


Lys Phe Phe Asp Ala Asn Tyr Asp Gly Lys Asp Tyr Asp Pro Val Ala 
        115                 120                 125             


Ala Arg Gln Gly Gln Glu Thr Ala Val Ala Pro Ser Leu Val Ala Pro 
    130                 135                 140                 


Ala Leu Asn Lys Pro Lys Lys Pro Leu Thr Ser Ser Ser Ala Ala Pro 
145                 150                 155                 160 


Gln Arg Pro Ile Ser Thr Gln Arg Thr Ala Ala Ala Pro Lys Ala Gly 
                165                 170                 175     


Pro Gly Val Val Arg Lys Asn Pro Gly Val Gly Asn Gly Asp Asp Glu 
            180                 185                 190         


Ala Ala Glu Leu Met Gln Gln Val Asn Val Leu Lys Leu Thr Val Glu 
        195                 200                 205             


Asp Leu Glu Lys Glu Arg Asp Phe Tyr Phe Gly Lys Leu Arg Asn Ile 
    210                 215                 220                 


Glu Leu Ile Cys Gln Glu Asn Glu Gly Glu Asn Asp Pro Val Leu Gln 
225                 230                 235                 240 


Arg Ile Val Asp Ile Leu Tyr Ala Thr Asp Glu Gly Phe Val Ile Pro 
                245                 250                 255     


Asp Glu Gly Gly Pro Gln Glu Glu Gln Glu Glu Tyr 
            260                 265             


<210>  116
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ser Tyr Phe Gly Glu His Phe Trp Gly Glu Lys Asn His Gly Phe 
1               5                   10                  15      


Glu Val Leu Tyr His Ser Val Lys Gln Gly Pro Ile Ser Thr Lys Glu 
            20                  25                  30          


Leu Ala Asp Phe Ile Arg Glu Arg Ala Thr Ile Glu Glu Thr Tyr Ser 
        35                  40                  45              


Lys Ala Met Ala Lys Leu Ser Lys Leu Ala Ser Asn Gly Thr Pro Met 
    50                  55                  60                  


Gly Thr Phe Ala Pro Leu Trp Glu Val Phe Arg Val Ser Ser Asp Lys 
65                  70                  75                  80  


Leu Ala Leu Cys His Leu Glu Leu Thr Arg Lys Leu Gln Asp Leu Ile 
                85                  90                  95      


Lys Asp Val Leu Arg Tyr Gly Glu Glu Gln Leu Lys Thr His Lys Lys 
            100                 105                 110         


Cys Lys Glu Glu Val Val Ser Thr Leu Asp Ala Val Gln Val Leu Ser 
        115                 120                 125             


Gly Val Ser Gln Leu Leu Pro Lys Ser Arg Glu Asn Tyr Leu Asn Arg 
    130                 135                 140                 


Cys Met Asp Gln Glu Arg Leu Arg Arg Glu Ser Thr Ser Gln Lys Glu 
145                 150                 155                 160 


Met Asp Lys Ala Glu Thr Lys Thr Lys Lys Ala Ala Glu Ser Leu Arg 
                165                 170                 175     


Arg Ser Val Glu Lys Tyr Asn Ser Ala Arg Ala Asp Phe Glu Gln Lys 
            180                 185                 190         


Met Leu Asp Ser Ala Leu Arg Phe Gln Ala Met Glu Glu Thr His Leu 
        195                 200                 205             


Arg His Met Lys Ala Leu Leu Gly Ser Tyr Ala His Ser Val Glu Asp 
    210                 215                 220                 


Thr His Val Gln Ile Gly Gln Val His Glu Glu Phe Lys Gln Asn Ile 
225                 230                 235                 240 


Glu Asn Val Ser Val Glu Met Leu Leu Arg Lys Phe Ala Glu Ser Lys 
                245                 250                 255     


Gly Thr Gly Arg Glu Lys Pro Gly Pro Leu Asp Phe Glu Ala Tyr Ser 
            260                 265                 270         


Ala Ala Ala Leu Gln Glu Ala Met Lys Arg Leu Arg Gly Ala Lys Ala 
        275                 280                 285             


Phe Arg Leu Pro Gly Leu Ser Arg Arg Glu Arg Glu Pro Glu Pro Pro 
    290                 295                 300                 


Ala Ala Val Asp Phe Leu Glu Pro Asp Ser Gly Thr Cys Pro Glu Val 
305                 310                 315                 320 


Asp Glu Glu Gly Phe Thr Val Arg Pro Asp Val Thr Gln Asn Ser Thr 
                325                 330                 335     


Ala Glu Pro Ser Arg Phe Ser Ser Ser Asp Ser Asp Phe Asp Asp Glu 
            340                 345                 350         


Glu Pro Arg Lys Phe Tyr Val His Ile Lys Pro Ala Pro Ala Arg Ala 
        355                 360                 365             


Pro Ala Cys Ser Pro Glu Ala Ala Ala Ala Gln Leu Arg Ala Thr Ala 
    370                 375                 380                 


Gly Ser Leu Ile Leu Pro Pro Gly Pro Gly Gly Thr Met Lys Arg His 
385                 390                 395                 400 


Ser Ser Arg Asp Ala Ala Gly Lys Pro Gln Arg Pro Arg Ser Ala Pro 
                405                 410                 415     


Arg Thr Ser Ser Cys Ala Glu Arg Leu Gln Ser Glu Glu Gln Val Ser 
            420                 425                 430         


Lys Asn Leu Phe Gly Pro Pro Leu Glu Ser Ala Phe Asp His Glu Asp 
        435                 440                 445             


Phe Thr Gly Ser Ser Ser Leu Gly Phe Thr Ser Ser Pro Ser Pro Phe 
    450                 455                 460                 


Ser Ser Ser Ser Pro Glu Asn Val Glu Asp Ser Gly Leu Asp Ser Pro 
465                 470                 475                 480 


Ser His Ala Ala Pro Gly Pro Ser Pro Asp Ser Trp Val Pro Arg Pro 
                485                 490                 495     


Gly Thr Pro Gln Ser Pro Pro Ser Cys Arg Ala Pro Pro Pro Glu Ala 
            500                 505                 510         


Arg Gly Ile Arg Ala Pro Pro Leu Pro Asp Ser Pro Gln Pro Leu Ala 
        515                 520                 525             


Ser Ser Pro Gly Pro Trp Gly Leu Glu Ala Leu Ala Gly Gly Asp Leu 
    530                 535                 540                 


Met Pro Ala Pro Ala Asp Pro Thr Ala Arg Glu Gly Leu Ala Ala Pro 
545                 550                 555                 560 


Pro Arg Arg Leu Arg Ser Arg Lys Val Ser Cys Pro Leu Thr Arg Ser 
                565                 570                 575     


Asn Gly Asp Leu Ser Arg Ser Leu Ser Pro Ser Pro Leu Gly Ser Ser 
            580                 585                 590         


Ala Ala Ser Thr Ala Leu Glu Arg Pro Ser Phe Leu Ser Gln Thr Gly 
        595                 600                 605             


His Gly Val Ser Arg Gly Pro Ser Pro Val Val Leu Gly Ser Gln Asp 
    610                 615                 620                 


Ala Leu Pro Ile Ala Thr Ala Phe Thr Glu Tyr Val His Ala Tyr Phe 
625                 630                 635                 640 


Arg Gly His Ser Pro Ser Cys Leu Ala Arg Val Thr Gly Glu Leu Thr 
                645                 650                 655     


Met Thr Phe Pro Ala Gly Ile Val Arg Val Phe Ser Gly Thr Pro Pro 
            660                 665                 670         


Pro Pro Val Leu Ser Phe Arg Leu Val His Thr Thr Ala Ile Glu His 
        675                 680                 685             


Phe Gln Pro Asn Ala Asp Leu Leu Phe Ser Asp Pro Ser Gln Ser Asp 
    690                 695                 700                 


Pro Glu Thr Lys Asp Phe Trp Leu Asn Met Ala Ala Leu Thr Glu Ala 
705                 710                 715                 720 


Leu Gln Arg Gln Ala Glu Gln Asn Pro Thr Ala Ser Tyr Tyr Asn Val 
                725                 730                 735     


Val Leu Leu Arg Tyr Gln Phe Ser Arg Pro Gly Pro Gln Ser Val Pro 
            740                 745                 750         


Leu Gln Leu Ser Ala His Trp Gln Cys Gly Ala Thr Leu Thr Gln Val 
        755                 760                 765             


Ser Val Glu Tyr Gly Tyr Arg Pro Gly Ala Thr Ala Val Pro Thr Pro 
    770                 775                 780                 


Leu Thr Asn Val Gln Ile Leu Leu Pro Val Gly Glu Pro Val Thr Asn 
785                 790                 795                 800 


Val Arg Leu Gln Pro Ala Ala Thr Trp Asn Leu Glu Glu Lys Arg Leu 
                805                 810                 815     


Thr Trp Arg Leu Pro Asp Val Ser Glu Ala Gly Gly Ser Gly Arg Leu 
            820                 825                 830         


Ser Ala Ser Trp Glu Pro Leu Ser Gly Pro Ser Thr Pro Ser Pro Val 
        835                 840                 845             


Ala Ala Gln Phe Thr Ser Glu Gly Thr Thr Leu Ser Gly Val Asp Leu 
    850                 855                 860                 


Glu Leu Val Gly Ser Gly Tyr Arg Met Ser Leu Val Lys Arg Arg Phe 
865                 870                 875                 880 


Ala Thr Gly Met Tyr Leu Val Ser Cys 
                885                 


<210>  117
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Thr Glu Asn Val 
1               5                   10                  15      


Tyr Lys Thr Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile 
            20                  25                  30          


Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Thr Tyr Ala 
        35                  40                  45              


Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser 
    50                  55                  60                  


Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala 
65                  70                  75                  80  


Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys Ser 
                85                  90                  95      


Phe His Asn Glu Leu Leu Thr Gln Leu Glu Gln Lys Val Glu Leu Asp 
            100                 105                 110         


Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys Tyr Gln Thr Glu Gln Arg 
        115                 120                 125             


Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys Leu 
    130                 135                 140                 


Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp Lys 
145                 150                 155                 160 


Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn Lys Gln Gly Glu Leu Glu 
                165                 170                 175     


Asn Tyr Val Ser Asp Gly Tyr Lys Thr Ala Leu Thr Glu Glu Arg Arg 
            180                 185                 190         


Arg Phe Cys Phe Leu Val Glu Lys Gln Cys Ala Val Ala Lys Asn Ser 
        195                 200                 205             


Ala Ala Tyr His Ser Lys Gly Lys Glu Leu Leu Ala Gln Lys Leu Pro 
    210                 215                 220                 


Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser Lys Ile Pro Glu Arg Ala 
225                 230                 235                 240 


Val Gln Leu Met Gln Gln Val Ala Ser Asn Gly Ala Thr Leu Pro Ser 
                245                 250                 255     


Ala Leu Ser Ala Ser Lys Ser Asn Leu Val Ile Ser Asp Pro Ile Pro 
            260                 265                 270         


Gly Ala Lys Pro Leu Pro Val Pro Pro Glu Leu Ala Pro Phe Val Gly 
        275                 280                 285             


Arg Met Ser Ala Gln Glu Ser Thr Pro Ile Met Asn Gly Val Thr Gly 
    290                 295                 300                 


Pro Asp Gly Glu Asp Tyr Ser Pro Trp Ala Asp Arg Lys Ala Ala Gln 
305                 310                 315                 320 


Pro Lys Ser Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp Ser 
                325                 330                 335     


Tyr Ser Asn Thr Leu Pro Val Arg Lys Ser Val Thr Pro Lys Asn Ser 
            340                 345                 350         


Tyr Ala Thr Thr Glu Asn Lys Thr Leu Pro Arg Ser Ser Ser Met Ala 
        355                 360                 365             


Ala Gly Leu Glu Arg Asn Gly Arg Met Arg Val Lys Ala Ile Phe Ser 
    370                 375                 380                 


His Ala Ala Gly Asp Asn Ser Thr Leu Leu Ser Phe Lys Glu Gly Asp 
385                 390                 395                 400 


Leu Ile Thr Leu Leu Val Pro Glu Ala Arg Asp Gly Trp His Tyr Gly 
                405                 410                 415     


Glu Ser Glu Lys Thr Lys Met Arg Gly Trp Phe Pro Phe Ser Tyr Thr 
            420                 425                 430         


Arg Val Leu Asp Ser Asp Gly Ser Asp Arg Leu His Met Ser Leu Gln 
        435                 440                 445             


Gln Gly Lys Ser Ser Ser Thr Gly Asn Leu Leu Asp Lys Asp Asp Leu 
    450                 455                 460                 


Ala Ile Pro Pro Pro Asp Tyr Gly Ala Ala Ser Arg Ala Phe Pro Ala 
465                 470                 475                 480 


Gln Thr Ala Ser Gly Phe Lys Gln Arg Pro Tyr Ser Val Ala Val Pro 
                485                 490                 495     


Ala Phe Ser Gln Gly Leu Asp Asp Tyr Gly Ala Arg Ser Met Ser Arg 
            500                 505                 510         


Asn Pro Phe Ala His Val Gln Leu Lys Pro Thr Val Thr Asn Asp Arg 
        515                 520                 525             


Cys Asp Leu Ser Ala Gln Gly Pro Glu Gly Arg Glu His Gly Asp Gly 
    530                 535                 540                 


Ser Ala Arg Thr Leu Ala Gly Arg 
545                 550         


<210>  118
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Glu Asp Leu Thr Asn Val Ser Ser Leu Leu Asn Met Glu Arg Ala 
1               5                   10                  15      


Arg Asp Lys Ala Asn Glu Glu Gly Leu Ala Leu Leu Gln Glu Glu Ile 
            20                  25                  30          


Asp Lys Met Val Glu Thr Thr Glu Leu Met Thr Gly Asn Ile Gln Ser 
        35                  40                  45              


Leu Lys Asn Lys Ile Gln Ile Leu Ala Ser Glu Val Glu Glu Glu Glu 
    50                  55                  60                  


Glu Arg Val Lys Gln Met His Gln Ile Asn Ser Ser Gly Val Leu Ser 
65                  70                  75                  80  


Leu Pro Glu Leu Ser Gln Lys Thr Leu Lys Ala Pro Thr Leu Gln Lys 
                85                  90                  95      


Glu Ile Leu Ala Leu Ile Pro Asn Gln Asn Ala Leu Leu Lys Asp Leu 
            100                 105                 110         


Asp Ile Leu His Asn Ser Ser Gln Met Lys Ser Met Ser Thr Phe Ile 
        115                 120                 125             


Glu Glu Ala Tyr Lys Lys Leu Asp Ala Ser 
    130                 135             


<210>  119
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Ala Gln Ser Gly Gly Glu Ala Arg Pro Gly Pro Lys Thr Ala Val 
1               5                   10                  15      


Gln Ile Arg Val Ala Ile Gln Glu Ala Glu Asp Val Asp Glu Leu Glu 
            20                  25                  30          


Asp Glu Glu Glu Gly Ala Glu Thr Arg Gly Ala Gly Asp Pro Ala Arg 
        35                  40                  45              


Tyr Leu Ser Pro Gly Trp Gly Ser Ala Ser Glu Glu Glu Pro Ser Arg 
    50                  55                  60                  


Gly His Ser Gly Thr Thr Ala Ser Gly Gly Glu Asn Glu Arg Glu Asp 
65                  70                  75                  80  


Leu Glu Gln Glu Trp Lys Pro Pro Asp Glu Glu Leu Ile Lys Lys Leu 
                85                  90                  95      


Val Asp Gln Ile Glu Phe Tyr Phe Ser Asp Glu Asn Leu Glu Lys Asp 
            100                 105                 110         


Ala Phe Leu Leu Lys His Val Arg Arg Asn Lys Leu Gly Tyr Val Ser 
        115                 120                 125             


Val Lys Leu Leu Thr Ser Phe Lys Lys Val Lys His Leu Thr Arg Asp 
    130                 135                 140                 


Trp Arg Thr Thr Ala His Ala Leu Lys Tyr Ser Val Val Leu Glu Leu 
145                 150                 155                 160 


Asn Glu Asp His Arg Lys Val Arg Arg Thr Thr Pro Val Pro Leu Phe 
                165                 170                 175     


Pro Asn Glu Asn Leu Pro Ser Lys Met Leu Leu Val Tyr Asp Leu Tyr 
            180                 185                 190         


Leu Ser Pro Lys Leu Trp Ala Leu Ala Thr Pro Gln Lys Asn Gly Arg 
        195                 200                 205             


Val Gln Glu Lys Val Met Glu His Leu Leu Lys Leu Phe Gly Thr Phe 
    210                 215                 220                 


Gly Val Ile Ser Ser Val Arg Ile Leu Lys Pro Gly Arg Glu Leu Pro 
225                 230                 235                 240 


Pro Asp Ile Arg Arg Ile Ser Ser Arg Tyr Ser Gln Val Gly Thr Gln 
                245                 250                 255     


Glu Cys Ala Ile Val Glu Phe Glu Glu Val Glu Ala Ala Ile Lys Ala 
            260                 265                 270         


His Glu Phe Met Ile Thr Glu Ser Gln Gly Lys Glu Asn Met Lys Ala 
        275                 280                 285             


Val Leu Ile Gly Met Lys Pro Pro Lys Lys Lys Pro Ala Lys Asp Lys 
    290                 295                 300                 


Asn His Asp Glu Glu Pro Thr Ala Ser Ile His Leu Asn Lys Ser Leu 
305                 310                 315                 320 


Asn Lys Arg Val Glu Glu Leu Gln Tyr Met Gly Asp Glu Ser Ser Ala 
                325                 330                 335     


Asn Ser Ser Ser Asp Pro Glu Ser Asn Pro Thr Ser Pro Met Ala Gly 
            340                 345                 350         


Arg Arg His Ala Ala Thr Asn Lys Leu Ser Pro Ser Gly His Gln Asn 
        355                 360                 365             


Leu Phe Leu Ser Pro Asn Ala Ser Pro Cys Thr Ser Pro Trp Ser Ser 
    370                 375                 380                 


Pro Leu Ala Gln Arg Lys Gly Val Ser Arg Lys Ser Pro Leu Ala Glu 
385                 390                 395                 400 


Glu Gly Arg Leu Asn Cys Ser Thr Ser Pro Glu Ile Phe Arg Lys Cys 
                405                 410                 415     


Met Asp Tyr Ser Ser Asp Ser Ser Val Thr Pro Ser Gly Ser Pro Trp 
            420                 425                 430         


Val Arg Arg Arg Arg Gln Ala Glu Met Gly Thr Gln Glu Lys Ser Pro 
        435                 440                 445             


Gly Thr Ser Pro Leu Leu Ser Arg Lys Met Gln Thr Ala Asp Gly Leu 
    450                 455                 460                 


Pro Val Gly Val Leu Arg Leu Pro Arg Gly Pro Asp Asn Thr Arg Gly 
465                 470                 475                 480 


Phe His Gly His Glu Arg Ser Arg Ala Cys Val 
                485                 490     


<210>  120
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Ser Thr Val Val Glu Leu Asn Val Gly Gly Glu Phe His Thr Thr 
1               5                   10                  15      


Thr Leu Gly Thr Leu Arg Lys Phe Pro Gly Ser Lys Leu Ala Glu Met 
            20                  25                  30          


Phe Ser Ser Leu Ala Lys Ala Ser Thr Asp Ala Glu Gly Arg Phe Phe 
        35                  40                  45              


Ile Asp Arg Pro Ser Thr Tyr Phe Arg Pro Ile Leu Asp Tyr Leu Arg 
    50                  55                  60                  


Thr Gly Gln Val Pro Thr Gln His Ile Pro Glu Val Tyr Arg Glu Ala 
65                  70                  75                  80  


Gln Phe Tyr Glu Ile Lys Pro Leu Val Lys Leu Leu Glu Asp Met Pro 
                85                  90                  95      


Gln Ile Phe Gly Glu Gln Val Ser Arg Lys Gln Phe Leu Leu Gln Val 
            100                 105                 110         


Pro Gly Tyr Ser Glu Asn Leu Glu Leu Met Val Arg Leu Ala Arg Ala 
        115                 120                 125             


Glu Ala Ile Thr Ala Arg Lys Ser Ser Val Leu Val Cys Leu Val Glu 
    130                 135                 140                 


Thr Glu Glu Gln Asp Ala Tyr Tyr Ser Glu Val Leu Cys Phe Leu Gln 
145                 150                 155                 160 


Asp Lys Lys Met Phe Lys Ser Val Val Lys Phe Gly Pro Trp Lys Ala 
                165                 170                 175     


Val Leu Asp Asn Ser Asp Leu Met His Cys Leu Glu Met Asp Ile Lys 
            180                 185                 190         


Ala Gln Gly Tyr Lys Val Phe Ser Lys Phe Tyr Leu Thr Tyr Pro Thr 
        195                 200                 205             


Lys Arg Asn Glu Phe His Phe Asn Ile Tyr Ser Phe Thr Phe Thr Trp 
    210                 215                 220                 


Trp 
225 


<210>  121
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Glu Ala Val Ala Thr Ala Thr Ala Ala Lys Glu Pro Asp Lys Gly 
1               5                   10                  15      


Cys Ile Glu Pro Gly Pro Gly His Trp Gly Glu Leu Ser Arg Thr Pro 
            20                  25                  30          


Val Pro Ser Lys Pro Gln Asp Lys Val Glu Ala Ala Glu Ala Thr Pro 
        35                  40                  45              


Val Ala Leu Asp Ser Asp Thr Ser Gly Ala Glu Asn Ala Ala Val Ser 
    50                  55                  60                  


Ala Met Leu His Ala Val Ala Ala Ser Arg Leu Pro Val Cys Ser Gln 
65                  70                  75                  80  


Gln Gln Gly Glu Pro Asp Leu Thr Glu His Glu Lys Val Ala Ile Leu 
                85                  90                  95      


Ala Gln Leu Tyr His Glu Lys Pro Leu Val Phe Leu Glu Arg Phe Arg 
            100                 105                 110         


Thr Gly Leu Arg Glu Glu His Leu Ala Cys Phe Gly His Val Arg Gly 
        115                 120                 125             


Asp His Arg Ala Asp Phe Tyr Cys Ala Glu Val Ala Arg Gln Gly Thr 
    130                 135                 140                 


Ala Arg Pro Arg Thr Leu Arg Thr Arg Leu Arg Asn Arg Arg Tyr Ala 
145                 150                 155                 160 


Ala Leu Arg Glu Leu Ile Gln Gly Gly Glu Tyr Phe Ser Asp Glu Gln 
                165                 170                 175     


Met Arg Phe Arg Ala Pro Leu Leu Tyr Glu Gln Tyr Ile Gly Gln Tyr 
            180                 185                 190         


Leu Thr Gln Glu Glu Leu Ser Ala Arg Thr Pro Thr His Gln Pro Pro 
        195                 200                 205             


Lys Pro Gly Ser Pro Gly Arg Pro Ala Cys Pro Leu Ser Asn Leu Leu 
    210                 215                 220                 


Leu Gln Ser Tyr Glu Glu Arg Glu Leu Gln Gln Arg Leu Leu Gln Gln 
225                 230                 235                 240 


Gln Glu Glu Glu Glu Ala Cys Leu Glu Glu Glu Glu Glu Glu Glu Asp 
                245                 250                 255     


Ser Asp Glu Glu Asp Gln Arg Ser Gly Lys Asp Ser Glu Ala Trp Val 
            260                 265                 270         


Pro Asp Ser Glu Glu Arg Leu Ile Leu Arg Glu Glu Phe Thr Ser Arg 
        275                 280                 285             


Met His Gln Arg Phe Leu Asp Gly Lys Asp Gly Asp Phe Asp Tyr Ser 
    290                 295                 300                 


Thr Val Asp Asp Asn Pro Asp Phe Asp Asn Leu Asp Ile Val Ala Arg 
305                 310                 315                 320 


Asp Glu Glu Glu Arg Tyr Phe Asp Glu Glu Glu Pro Glu Asp Ala Pro 
                325                 330                 335     


Ser Pro Glu Leu Asp Gly Asp 
            340             


<210>  122
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp 
1               5                   10                  15      


Ala Gly Ala Asp Asp Trp Glu Thr Asp Pro Asp Phe Val Asn Asp Val 
            20                  25                  30          


Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Val Gln Gly Ser Gly 
        35                  40                  45              


His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln 
    50                  55                  60                  


Glu His Gln Thr Leu Lys Glu Lys Glu Leu Glu Thr Gly Pro Lys Ala 
65                  70                  75                  80  


Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp 
                85                  90                  95      


Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys 
            100                 105                 110         


Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln 
        115                 120                 125             


Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys 
    130                 135                 140                 


Thr Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly 
145                 150                 155                 160 


Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe 
                165                 170                 175     


Asp Tyr Gln Gly Lys Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ser 
            180                 185                 190         


Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys 
        195                 200                 205             


Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Thr Glu Lys His Glu Ser 
    210                 215                 220                 


Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Thr 
225                 230                 235                 240 


Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu 
                245                 250                 255     


Gln Leu His Glu Ser Gln Lys Asp Tyr Ser Lys Gly Phe Gly Gly Lys 
            260                 265                 270         


Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn Ala Ser Thr Phe Glu 
        275                 280                 285             


Asp Val Thr Gln Val Ser Ser Ala Tyr Gln Lys Thr Val Pro Val Glu 
    290                 295                 300                 


Ala Val Thr Ser Lys Thr Ser Asn Ile Arg Ala Asn Phe Glu Asn Leu 
305                 310                 315                 320 


Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys Ala Glu Ala Glu Arg 
                325                 330                 335     


Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln Glu Glu Ala Arg Arg 
            340                 345                 350         


Lys Leu Glu Glu Gln Ala Arg Ala Lys Thr Gln Thr Pro Pro Val Ser 
        355                 360                 365             


Pro Ala Pro Gln Pro Thr Glu Glu Arg Leu Pro Ser Ser Pro Val Tyr 
    370                 375                 380                 


Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser Tyr Arg Gly Pro Val 
385                 390                 395                 400 


Ser Gly Thr Glu Pro Glu Pro Val Tyr Ser Met Glu Ala Ala Asp Tyr 
                405                 410                 415     


Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr Ala Thr Glu Ala Val 
            420                 425                 430         


Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro Ala Glu Asp Ser Thr 
        435                 440                 445             


Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Ile Thr Ala Val Ala Leu Tyr 
    450                 455                 460                 


Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser Phe Asp Pro Asp Asp 
465                 470                 475                 480 


Ile Ile Thr Asn Ile Glu Met Ile Asp Asp Gly Trp Trp Arg Gly Val 
                485                 490                 495     


Cys Lys Gly Arg Tyr Gly Leu Phe Pro Ala Asn Tyr Val Glu Leu Arg 
            500                 505                 510         


Gln 
    


<210>  123
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Glu Val His Gly Lys Pro Gln Ala Ser Pro Ser Cys Ser Ser Pro 
1               5                   10                  15      


Thr Arg Asp Ser Ser Gly Val Pro Val Ser Lys Glu Leu Leu Thr Ala 
            20                  25                  30          


Gly Ser Asp Gly Arg Gly Gly Ile Trp Asp Arg Leu Leu Ile Asn Ser 
        35                  40                  45              


Gln Pro Lys Ser Arg Lys Thr Ser Thr Leu Gln Thr Val Arg Ile Glu 
    50                  55                  60                  


Arg Ser Pro Leu Leu Asp Gln Val Gln Thr Phe Leu Pro Gln Met Ala 
65                  70                  75                  80  


Arg Ala Asn Glu Lys Leu Arg Lys Glu Met Ala Ala Ala Pro Pro Gly 
                85                  90                  95      


Arg Phe Asn Ile Glu Asn Ile Asp Gly Pro His Ser Lys Val Ile Gln 
            100                 105                 110         


Met Asp Val Ala Leu Phe Glu Met Asn Gln Ser Asp Ser Lys Glu Val 
        115                 120                 125             


Asp Ser Ser Glu Glu Ser Ser Gln Asp Ser Ser Glu Asn Ser Ser Glu 
    130                 135                 140                 


Ser Glu Asp Glu Asp Asp Ser Ile Pro Ser Glu Val Thr Ile Asp Asn 
145                 150                 155                 160 


Ile Lys Leu Pro Asn Ser Glu Gly Gly Lys Gly Lys Ile Glu Val Leu 
                165                 170                 175     


Asp Ser Pro Ala Ser Lys Lys Lys Glu Ile Val Lys 
            180                 185             


<210>  124
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly 
1               5                   10                  15      


Tyr Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro 
            20                  25                  30          


Pro Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val 
        35                  40                  45              


Leu Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly 
    50                  55                  60                  


Val Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu 
65                  70                  75                  80  


Asp Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr 
                85                  90                  95      


Lys Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His 
            100                 105                 110         


Lys Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly 
        115                 120                 125             


Lys Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val 
    130                 135                 140                 


Phe Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp 
145                 150                 155                 160 


Ile Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile 
                165                 170                 175     


Lys Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu 
            180                 185                 190         


Glu Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu 
        195                 200                 205             


Glu Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn 
    210                 215                 220                 


Asp Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser 
225                 230                 235                 240 


Ser Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu 
                245                 250                 255     


Glu Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys 
            260                 265                 270         


Arg Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val 
        275                 280                 285             


Ser Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys 
    290                 295                 300                 


Glu Glu Ala Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu 
305                 310                 315                 320 


Trp Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro 
                325                 330                 335     


Leu His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile 
            340                 345                 350         


Ser Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met 
        355                 360                 365             


Arg Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg 
    370                 375                 380                 


Gly Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp 
385                 390                 395                 400 


Asn Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val 
                405                 410                 415     


Asn Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln 
            420                 425                 430         


His Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile 
        435                 440                 445             


His Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr 
    450                 455                 460                 


Pro Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn 
465                 470                 475                 480 


Ile Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu 
                485                 490                 495     


Leu Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly 
            500                 505                 510         


Asn Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val 
        515                 520                 525             


Leu Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr 
    530                 535                 540                 


Tyr Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys 
545                 550                 555                 560 


Gly Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His 
                565                 570                 575     


Gly Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro 
            580                 585                 590         


Leu Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met 
        595                 600                 605             


Gly Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn 
    610                 615                 620                 


Thr Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys 
625                 630                 635                 640 


Lys Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His 
                645                 650                 655     


Ala Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn 
            660                 665                 670         


Phe Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala 
        675                 680                 685             


Gln Pro Pro Gly Pro Ala Gln Ile Leu Pro Pro Gly Leu Thr Pro Gly 
    690                 695                 700                 


Leu Pro Tyr Pro His Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln 
705                 710                 715                 720 


Pro Arg Pro Pro Ile Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala 
                725                 730                 735     


Val Pro Thr Gly Gly Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly 
            740                 745                 750         


Arg Gly Asn Tyr Asp Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys 
        755                 760                 765             


Pro Arg Asn Arg Met Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr 
    770                 775                 780                 


Arg Asp Leu Asp Ala Pro Asp Asp Val Asp Phe Phe 
785                 790                 795     


<210>  125
<211>  317
<212>  PRT
<213>  Homo sapien

<400>  125

Met Arg Lys Thr Ser Asn Ser Cys Ile Met Glu Asn Gly His Gln Pro 
1               5                   10                  15      


Gly Thr Gly Pro Gly Asp Gly Pro Pro Glu Ile Ala Gln Asn Phe Ser 
            20                  25                  30          


Ala Pro Asp Pro Pro Arg Pro Arg Pro Val Ser Leu Ser Leu Arg Leu 
        35                  40                  45              


Pro His Gln Pro Val Thr Ala Ile Thr Arg Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Glu Thr Ser Ala Ala Ala Leu Ser Pro Met Ser Ala Ala Thr Leu 
65                  70                  75                  80  


Gly Gly Leu Asn Pro Ser Pro Ser Glu Val Ile Thr Pro Trp Thr Pro 
                85                  90                  95      


Ser Pro Ser Glu Lys Asn Ser Ser Phe Thr Trp Ser Val Pro Ser Ser 
            100                 105                 110         


Gly Tyr Gly Ala Val Thr Ala Ser Lys His Ser Asn Ser Pro Pro Leu 
        115                 120                 125             


Val Thr Pro Pro Gln Ser Pro Val Ser Pro Gln Pro Pro Ala Ile Thr 
    130                 135                 140                 


Gln Val His Arg Gln Gly Glu Arg Arg Arg Glu Leu Val Arg Ser Gln 
145                 150                 155                 160 


Thr Leu Pro Arg Thr Ser Glu Ala Gln Ala Arg Lys Ala Leu Phe Glu 
                165                 170                 175     


Lys Trp Glu Gln Glu Thr Ala Ala Gly Lys Gly Lys Gly Glu Ala Arg 
            180                 185                 190         


Ala Arg Leu Lys Arg Ser Gln Ser Phe Gly Val Ala Ser Ala Ser Ser 
        195                 200                 205             


Ile Lys Gln Ile Leu Leu Glu Trp Cys Arg Ser Lys Thr Leu Gly Tyr 
    210                 215                 220                 


Gln His Val Asp Leu Gln Asn Phe Ser Ser Ser Trp Ser Asp Gly Met 
225                 230                 235                 240 


Ala Phe Cys Ala Leu Val His Ser Phe Phe Pro Asp Ala Phe Asp Tyr 
                245                 250                 255     


Asn Ser Leu Ser Pro Thr Gln Arg Gln Lys Asn Phe Glu Leu Ala Phe 
            260                 265                 270         


Thr Met Ala Glu Asn Leu Ala Asn Cys Glu Arg Leu Ile Glu Val Glu 
        275                 280                 285             


Asp Met Met Val Met Gly Arg Lys Pro Asp Pro Met Cys Val Phe Thr 
    290                 295                 300                 


Tyr Val Gln Ser Leu Tyr Asn His Leu Arg Arg Phe Glu 
305                 310                 315         


<210>  126
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Tyr Arg Val Ile Gln Val Ser Glu Gly Gln Leu Asp Gly Gln Thr 
1               5                   10                  15      


Glu Gly Thr Gly Ala Ile Ser Gly Tyr Pro Ala Thr Gln Ser Met Thr 
            20                  25                  30          


Gln Ala Val Ile Gln Gly Ala Phe Thr Ser Asp Asp Ala Val Asp Thr 
        35                  40                  45              


Glu Gly Thr Ala Ala Glu Thr His Tyr Thr Tyr Phe Pro Ser Thr Ala 
    50                  55                  60                  


Val Gly Asp Gly Ala Gly Gly Thr Thr Ser Gly Ser Thr Ala Ala Val 
65                  70                  75                  80  


Val Thr Thr Gln Gly Ser Glu Ala Leu Leu Gly Gln Ala Thr Pro Pro 
                85                  90                  95      


Gly Thr Gly Gln Phe Phe Val Met Met Ser Pro Gln Glu Val Leu Gln 
            100                 105                 110         


Gly Gly Ser Gln Arg Ser Ile Ala Pro Arg Thr His Pro Tyr Ser Pro 
        115                 120                 125             


Lys Ser Glu Ala Pro Arg Thr Thr Arg Asp Glu Lys Arg Arg Ala Gln 
    130                 135                 140                 


His Asn Glu Val Glu Arg Arg Arg Arg Asp Lys Ile Asn Asn Trp Ile 
145                 150                 155                 160 


Val Gln Leu Ser Lys Ile Ile Pro Asp Cys Ser Met Glu Ser Thr Lys 
                165                 170                 175     


Ser Gly Gln Ser Lys Gly Gly Ile Leu Ser Lys Ala Cys Asp Tyr Ile 
            180                 185                 190         


Gln Glu Leu Arg Gln Ser Asn His Arg Leu Ser Glu Glu Leu Gln Gly 
        195                 200                 205             


Leu Asp Gln Leu Gln Leu Asp Asn Asp Val Leu Arg Gln Gln Val Glu 
    210                 215                 220                 


Asp Leu Lys Asn Lys Asn Leu Leu Leu Arg Ala Gln Leu Arg His His 
225                 230                 235                 240 


Gly Leu Glu Val Val Ile Lys Asn Asp Ser Asn 
                245                 250     


<210>  127
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  127

Met His Ser Thr Pro Ala Asn Pro Val Glu Ala Val Val Gln Arg Ala 
1               5                   10                  15      


Gly Phe Val Ala Ser Gln Ala Ser Leu Arg Pro Trp Lys Gln Asp Arg 
            20                  25                  30          


Arg Ala Gly Asp Pro Trp Pro Arg Thr His Glu Phe Gly Tyr Pro Glu 
        35                  40                  45              


Ala Ser Leu Gln Ala Ser Ala Cys Lys Lys Lys Lys Ser Lys Asp Lys 
    50                  55                  60                  


Lys Arg Lys Arg Glu Asp Glu Glu Thr Gln Leu Asp Thr Leu Glu Ser 
65                  70                  75                  80  


Gly Glu Gln 
            


<210>  128
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  128

Ala Pro Phe Leu Arg Ile Ala Phe Asn Ser Tyr Glu Leu Gly Ser Leu 
1               5                   10                  15      


Gln Ala Glu Asp Glu Ala Asn Gln Pro Phe Cys Ala Val Lys Met Lys 
            20                  25                  30          


Glu Ala Leu Ser Thr Glu Arg Gly Lys Thr Leu Val Gln Lys Lys Pro 
        35                  40                  45              


Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr Glu 
    50                  55                  60                  


Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Glu Pro Val 
65                  70                  75                  80  


Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys Lys 
                85                  90                  95      


Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala Lys 
            100                 105                 110         


Val Leu Met Ser Val Gln Tyr Phe Leu Glu Asp Val Asp Cys Lys Gln 
        115                 120                 125             


Ser Met Arg Ser Glu Asp Glu Ala Lys Phe Pro Thr Met Asn Arg Arg 
    130                 135                 140                 


Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu Phe 
145                 150                 155                 160 


Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys Asp 
                165                 170                 175     


Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys Asn 
            180                 185                 190         


Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys Thr 
        195                 200                 205             


Gly Thr Ala Ala Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg Phe 
    210                 215                 220                 


Asn Ile Asp Met Pro His Arg Phe Lys Val His Asn Tyr Met Ser Pro 
225                 230                 235                 240 


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Leu Val Lys Gln 
                245                 250                 255     


Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys Arg 
            260                 265                 270         


Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala Glu 
        275                 280                 285             


Ala Leu Asn Gln Val Thr Gln Arg Ala Ser Arg Arg Ser Asp Ser Ala 
    290                 295                 300                 


Ser Ser Glu Pro Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr Gly 
305                 310                 315                 320 


Val Ala Gly Glu Asp Met Gln Asp Asn Ser Gly Thr Tyr Gly Lys Ile 
                325                 330                 335     


Trp Glu Gly Ser Ser Lys Cys Asn Ile Asn Asn Phe Ile Phe His Lys 
            340                 345                 350         


Val Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Gly Glu Leu Lys 
        355                 360                 365             


Gly Arg Gly Glu Tyr Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 
    370                 375                 380                 


Leu Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
385                 390                 395                 400 


Thr Leu Ala Ala Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr Phe 
                405                 410                 415     


Gln Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly Gly 
            420                 425                 430         


Asp Leu Met Tyr His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr Arg 
        435                 440                 445             


Ala Thr Phe Tyr Ala Ala Glu Ile Met Cys Gly Leu Gln Phe Leu His 
    450                 455                 460                 


Ser Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu Leu 
465                 470                 475                 480 


Asp Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
                485                 490                 495     


Asn Ile Phe Gly Glu Ser Arg Ala Ser Thr Phe Cys Gly Thr Pro Asp 
            500                 505                 510         


Tyr Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Thr Phe Ser Val 
        515                 520                 525             


Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln 
    530                 535                 540                 


Ser Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile Arg 
545                 550                 555                 560 


Val Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys Asp 
                565                 570                 575     


Ile Leu Glu Lys Leu Phe Glu Arg Glu Pro Thr Lys Arg Leu Gly Val 
            580                 585                 590         


Thr Gly Asn Ile Lys Ile His Pro Phe Phe Lys Thr Ile Asn Trp Thr 
        595                 600                 605             


Leu Leu Glu Lys Arg Arg Leu Glu Pro Pro Phe Arg Pro Lys Val Lys 
    610                 615                 620                 


Ser Pro Arg Asp Tyr Ser Asn Phe Asp Gln Glu Phe Leu Asn Glu Lys 
625                 630                 635                 640 


Ala Arg Leu Ser Tyr Ser Asp Lys Asn Leu Ile Asp Ser Met Asp Gln 
                645                 650                 655     


Ser Ala Phe Ala Gly Phe Ser Phe Val Asn Pro Lys Phe Glu His Leu 
            660                 665                 670         


Leu Glu Asp 
        675 


<210>  129
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  129

Ala Ser Gln Arg Leu Arg Leu Pro Leu Pro Leu Arg Ala Ala Pro Ala 
1               5                   10                  15      


Arg Leu Ser Pro Ala Pro Ala Ala Pro Pro Arg Arg Asp Leu Gly His 
            20                  25                  30          


Arg Pro Ala Pro Arg Ala Arg Gly Arg Pro Glu Pro Ala Pro Leu Pro 
        35                  40                  45              


Arg Arg Pro Arg Pro Pro Gly Pro Pro Arg Pro Gln Leu Pro Gly Gly 
    50                  55                  60                  


Gly Lys Arg Trp Leu Gly Gly Thr Met Ala Asp Val Phe Pro Gly Asn 
65                  70                  75                  80  


Asp Ser Thr Ala Ser Gln Asp Val Ala Asn Arg Phe Ala Arg Lys Gly 
                85                  90                  95      


Ala Leu Arg Gln Lys Asn Val His Glu Val Lys Asp His Lys Phe Ile 
            100                 105                 110         


Ala Arg Phe Phe Lys Gln Pro Thr Phe Cys Ser His Cys Thr Asp Phe 
        115                 120                 125             


Ile Trp Gly Phe Gly Lys Gln Gly Phe Gln Cys Gln Val Cys Cys Phe 
    130                 135                 140                 


Val Val His Lys Arg Cys His Glu Phe Val Thr Phe Ser Cys Pro Gly 
145                 150                 155                 160 


Ala Asp Lys Gly Pro Asp Thr Asp Asp Pro Arg Ser Lys His Lys Phe 
                165                 170                 175     


Lys Ile His Thr Tyr Gly Ser Pro Thr Phe Cys Asp His Cys Gly Ser 
            180                 185                 190         


Leu Leu Tyr Gly Leu Ile His Gln Gly Met Lys Cys Asp Thr Cys Asp 
        195                 200                 205             


Met Asn Val His Lys Gln Cys Val Ile Asn Val Pro Ser Leu Cys Gly 
    210                 215                 220                 


Met Asp His Thr Glu Lys Arg Gly Arg Ile Tyr Leu Lys Ala Glu Val 
225                 230                 235                 240 


Ala Asp Glu Lys Leu His Val Thr Val Arg Asp Ala Lys Asn Leu Ile 
                245                 250                 255     


Pro Met Asp Pro Asn Gly Leu Ser Asp Pro Tyr Val Lys Leu Lys Leu 
            260                 265                 270         


Ile Pro Asp Pro Lys Asn Glu Ser Lys Gln Lys Thr Lys Thr Ile Arg 
        275                 280                 285             


Ser Thr Leu Asn Pro Gln Trp Asn Glu Ser Phe Thr Phe Lys Leu Lys 
    290                 295                 300                 


Pro Ser Asp Lys Asp Arg Arg Leu Ser Val Glu Ile Trp Asp Trp Asp 
305                 310                 315                 320 


Arg Thr Thr Arg Asn Asp Phe Met Gly Ser Leu Ser Phe Gly Val Ser 
                325                 330                 335     


Glu Leu Met Lys Met Pro Ala Ser Gly Trp Tyr Lys Leu Leu Asn Gln 
            340                 345                 350         


Glu Glu Gly Glu Tyr Tyr Asn Val Pro Ile Pro Glu Gly Asp Glu Glu 
        355                 360                 365             


Gly Asn Met Glu Leu Arg Gln Lys Phe Glu Trp Arg 
    370                 375                 380 


<210>  130
<211>  1620
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Val Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Arg Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Glu Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  131
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met 
1               5                   10                  15      


Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu 
            20                  25                  30          


Phe Gly Pro Val Asp His Glu Glu Leu Thr Arg Asp Leu Glu Lys His 
        35                  40                  45              


Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe 
    50                  55                  60                  


Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu 
65                  70                  75                  80  


Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys 
                85                  90                  95      


Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser 
            100                 105                 110         


Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Thr 
        115                 120                 125             


His Leu Val Asp Pro Lys Thr Asp Pro Ser Asp Ser Gln Thr Gly Leu 
    130                 135                 140                 


Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Thr Asp Asp Ser 
145                 150                 155                 160 


Ser Thr Gln Asn Lys Arg Ala Asn Arg Thr Glu Glu Asn Val Ser Asp 
                165                 170                 175     


Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly 
            180                 185                 190         


Leu Arg Arg Arg Gln Thr 
        195             


<210>  132
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser 
385                 390                 395                 400 


Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg 
                405                 410                 415     


Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430         


<210>  133
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg 
1               5                   10                  15      


Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly 
        35                  40                  45              


Gly Lys Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser 
    50                  55                  60                  


Ser Gly Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp 
                85                  90                  95      


Ser Gly Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu 
            100                 105                 110         


Arg Ser Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly 
        115                 120                 125             


Ser Phe Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu 
    130                 135                 140                 


Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu 
145                 150                 155                 160 


Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg 
                165                 170                 175     


Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn 
            180                 185                 190         


Leu Val Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His 
        195                 200                 205             


Phe Thr Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr 
    210                 215                 220                 


Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val 
225                 230                 235                 240 


Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr 
                245                 250                 255     


Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val Arg 
            260                 265                 270         


Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro 
        275                 280                 285             


Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp 
    290                 295                 300                 


Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe 
305                 310                 315                 320 


Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu 
                325                 330                 335     


Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr 
            340                 345                 350         


Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe 
        355                 360                 365             


Lys Ser Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu 
    370                 375                 380                 


Glu Tyr Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His 
385                 390                 395                 400 


Ser Phe Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn 
                405                 410                 415     


Arg Pro Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile 
            420                 425                 430         


Gln Pro Ser Leu Asn Ala Ile Leu Ile Pro Pro His Leu Arg Ser Pro 
        435                 440                 445             


Ala Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr 
    450                 455                 460                 


Pro Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr 
465                 470                 475                 480 


Asn Ser Ser 
            


<210>  134
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Lys Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  135
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Asn Phe Cys Phe Pro Val 
    210                 215                 220                 


Phe 
225 


<210>  136
<211>  658
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Asn Gln Pro Gln Arg Met Ala Pro Val Gly Thr Asp Lys Glu Leu 
1               5                   10                  15      


Ser Asp Leu Leu Asp Phe Ser Met Met Phe Pro Leu Pro Val Thr Asn 
            20                  25                  30          


Gly Lys Gly Arg Pro Ala Ser Leu Ala Gly Ala Gln Phe Gly Gly Ser 
        35                  40                  45              


Gly Lys Ser Gly Glu Arg Gly Ala Tyr Ala Ser Phe Gly Arg Asp Ala 
    50                  55                  60                  


Gly Val Gly Gly Leu Thr Gln Ala Gly Phe Leu Ser Gly Glu Leu Ala 
65                  70                  75                  80  


Leu Asn Ser Pro Gly Pro Leu Ser Pro Ser Gly Met Lys Gly Thr Ser 
                85                  90                  95      


Gln Tyr Tyr Pro Ser Tyr Ser Gly Ser Ser Arg Arg Arg Ala Ala Asp 
            100                 105                 110         


Gly Ser Leu Asp Thr Gln Pro Lys Lys Val Arg Lys Val Pro Pro Gly 
        115                 120                 125             


Leu Pro Ser Ser Val Tyr Pro Pro Ser Ser Gly Glu Asp Tyr Gly Arg 
    130                 135                 140                 


Asp Ala Thr Ala Tyr Pro Ser Ala Lys Thr Pro Ser Ser Thr Tyr Pro 
145                 150                 155                 160 


Ala Pro Phe Tyr Val Ala Asp Gly Ser Leu His Pro Ser Ala Glu Leu 
                165                 170                 175     


Trp Ser Pro Pro Gly Gln Ala Gly Phe Gly Pro Met Leu Gly Gly Gly 
            180                 185                 190         


Ser Ser Pro Leu Pro Leu Pro Pro Gly Ser Gly Pro Val Gly Ser Ser 
        195                 200                 205             


Gly Ser Ser Ser Thr Phe Gly Gly Leu His Gln His Glu Arg Met Gly 
    210                 215                 220                 


Tyr Gln Leu His Gly Ala Glu Val Asn Gly Gly Leu Pro Ser Ala Ser 
225                 230                 235                 240 


Ser Phe Ser Ser Ala Pro Gly Ala Thr Tyr Gly Gly Val Ser Ser His 
                245                 250                 255     


Thr Pro Pro Val Ser Gly Ala Asp Ser Leu Leu Gly Ser Arg Gly Thr 
            260                 265                 270         


Thr Ala Gly Ser Ser Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile 
        275                 280                 285             


Tyr Ser Pro Asp His Ser Ser Asn Asn Phe Ser Ser Ser Pro Ser Thr 
    290                 295                 300                 


Pro Val Gly Ser Pro Gln Gly Leu Ala Gly Thr Ser Gln Trp Pro Arg 
305                 310                 315                 320 


Ala Gly Ala Pro Gly Ala Leu Ser Pro Ser Tyr Asp Gly Gly Leu His 
                325                 330                 335     


Gly Leu Gln Ser Lys Ile Glu Asp His Leu Asp Glu Ala Ile His Val 
            340                 345                 350         


Leu Arg Ser His Ala Val Gly Thr Ala Gly Asp Met His Thr Leu Leu 
        355                 360                 365             


Pro Gly His Gly Ala Leu Ala Ser Gly Phe Thr Gly Pro Met Ser Leu 
    370                 375                 380                 


Gly Gly Arg His Ala Gly Leu Val Gly Gly Ser His Pro Glu Asp Gly 
385                 390                 395                 400 


Leu Ala Gly Ser Thr Ser Leu Met His Asn His Ala Ala Leu Pro Ser 
                405                 410                 415     


Gln Pro Gly Thr Leu Pro Asp Leu Ser Arg Pro Pro Asp Ser Tyr Ser 
            420                 425                 430         


Gly Leu Gly Arg Ala Gly Ala Thr Ala Ala Ala Ser Glu Ile Lys Arg 
        435                 440                 445             


Glu Glu Lys Glu Asp Glu Glu Asn Thr Ser Ala Ala Asp His Ser Glu 
    450                 455                 460                 


Glu Glu Lys Lys Glu Leu Lys Ala Pro Arg Ala Arg Thr Arg Cys Gln 
465                 470                 475                 480 


Pro Thr Pro Arg His Ser Pro Pro Ser Pro His Gln Asp Ala His Val 
                485                 490                 495     


His Arg Pro His Ala His Arg Thr His Thr Gly Arg Pro Ser Ala Gly 
            500                 505                 510         


Pro Thr Leu Phe Pro Gln Pro His Cys Leu Pro Leu Ala Pro Ser Arg 
        515                 520                 525             


Arg Pro Pro His Ser Pro Asp Glu Asp Glu Asp Asp Leu Leu Pro Pro 
    530                 535                 540                 


Glu Gln Lys Ala Glu Arg Glu Lys Glu Arg Arg Val Ala Asn Asn Ala 
545                 550                 555                 560 


Arg Glu Arg Leu Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu 
                565                 570                 575     


Gly Arg Met Cys Gln Leu His Leu Asn Ser Glu Lys Pro Gln Thr Lys 
            580                 585                 590         


Leu Leu Ile Leu His Gln Ala Val Ser Val Ile Leu Asn Leu Glu Gln 
        595                 600                 605             


Gln Val Arg Glu Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg 
    610                 615                 620                 


Arg Glu Glu Glu Lys Val Ser Gly Val Val Gly Asp Pro Gln Met Val 
625                 630                 635                 640 


Leu Ser Ala Pro His Pro Gly Leu Ser Glu Ala His Asn Pro Ala Gly 
                645                 650                 655     


His Met 
        


<210>  137
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Gln Gly His Phe Pro Ala Glu Arg Arg Glu Gly Arg Pro Arg Arg 
1               5                   10                  15      


Gly Thr Arg Gly Gln Gln Gln Leu Leu Val Ser Pro Arg Phe Leu Arg 
            20                  25                  30          


Ala Trp His Pro Pro Pro Val Ser Ala Arg Met Pro Thr Arg Arg Trp 
        35                  40                  45              


Ala Pro Gly Thr Gln Cys Ile Thr Lys Cys Glu His Thr Arg Pro Lys 
    50                  55                  60                  


Pro Gly Glu Leu Ala Phe Arg Lys Gly Asp Val Val Thr Ile Leu Glu 
65                  70                  75                  80  


Ala Cys Glu Asn Lys Ser Trp Tyr Arg Val Lys His His Thr Ser Gly 
                85                  90                  95      


Gln Glu Gly Leu Leu Ala Ala Gly Ala Leu Arg Glu Arg Glu Ala Leu 
            100                 105                 110         


Ser Ala Asp Pro Lys Leu Ser Leu Met Pro Trp Phe His Gly Lys Ile 
        115                 120                 125             


Ser Gly Gln Glu Ala Val Gln Gln Leu Gln Pro Pro Glu Asp Gly Leu 
    130                 135                 140                 


Phe Leu Val Arg Glu Ser Ala Arg His Pro Gly Asp Tyr Val Leu Cys 
145                 150                 155                 160 


Val Ser Phe Gly Arg Asp Val Ile His Tyr Arg Val Leu His Arg Asp 
                165                 170                 175     


Gly His Leu Thr Ile Asp Glu Ala Val Phe Phe Cys Asn Leu Met Asp 
            180                 185                 190         


Met Val Glu His Tyr Ser Lys Asp Lys Gly Ala Ile Cys Thr Lys Leu 
        195                 200                 205             


Val Arg Pro Lys Arg Lys His Gly Thr Lys Ser Ala Glu Glu Glu Leu 
    210                 215                 220                 


Ala Arg Ala Gly Trp Leu Leu Asn Leu Gln His Leu Thr Leu Gly Ala 
225                 230                 235                 240 


Gln Ile Gly Glu Gly Glu Phe Gly Ala Val Leu Gln Gly Glu Tyr Leu 
                245                 250                 255     


Gly Gln Lys Val Ala Val Lys Asn Ile Lys Cys Asp Val Thr Ala Gln 
            260                 265                 270         


Ala Phe Leu Asp Glu Thr Ala Val Met Thr Lys Met Gln His Glu Asn 
        275                 280                 285             


Leu Val Arg Leu Leu Gly Val Ile Leu His Gln Gly Leu Tyr Ile Val 
    290                 295                 300                 


Met Glu His Val Ser Lys Gly Asn Leu Val Asn Phe Leu Arg Thr Arg 
305                 310                 315                 320 


Gly Arg Ala Leu Val Asn Thr Ala Gln Leu Leu Gln Phe Ser Leu His 
                325                 330                 335     


Val Ala Glu Gly Met Glu Tyr Leu Glu Ser Lys Lys Leu Val His Arg 
            340                 345                 350         


Asp Leu Ala Ala Arg Asn Ile Leu Val Ser Glu Asp Leu Val Ala Lys 
        355                 360                 365             


Val Ser Asp Phe Gly Leu Ala Lys Ala Glu Arg Lys Gly Leu Asp Ser 
    370                 375                 380                 


Ser Arg Leu Pro Val Lys Trp Thr Ala Pro Glu Ala Leu Lys His Gly 
385                 390                 395                 400 


Lys Phe Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp 
                405                 410                 415     


Glu Val Phe Ser Tyr Gly Arg Ala Pro Tyr Pro Lys Met Ser Leu Lys 
            420                 425                 430         


Glu Val Ser Glu Ala Val Glu Lys Gly Tyr Arg Met Glu Pro Pro Glu 
        435                 440                 445             


Gly Cys Pro Gly Pro Val His Val Leu Met Ser Ser Cys Trp Glu Ala 
    450                 455                 460                 


Glu Pro Ala Arg Arg Pro Pro Phe Arg Lys Leu Ala Glu Lys Leu Ala 
465                 470                 475                 480 


Arg Glu Leu Arg Ser Ala Gly Ala Pro Ala Ser Val Ser Gly Gln Asp 
                485                 490                 495     


Ala Asp Gly Ser Thr Ser Pro Arg Ser Gln Glu Pro 
            500                 505             


<210>  138
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Ser Gln Ser Lys Gly Lys Lys Arg Asn Pro Gly Leu Lys Ile Pro 
1               5                   10                  15      


Lys Glu Ala Phe Glu Gln Pro Gln Thr Ser Ser Thr Pro Pro Arg Asp 
            20                  25                  30          


Leu Asp Ser Lys Ala Cys Ile Ser Ile Gly Asn Gln Asn Phe Glu Val 
        35                  40                  45              


Lys Ala Asp Asp Leu Glu Pro Ile Met Glu Leu Gly Arg Gly Ala Tyr 
    50                  55                  60                  


Gly Val Val Glu Lys Met Arg His Val Pro Ser Gly Gln Ile Met Ala 
65                  70                  75                  80  


Val Lys Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu 
                85                  90                  95      


Leu Met Asp Leu Asp Ile Ser Met Arg Thr Val Asp Cys Pro Phe Thr 
            100                 105                 110         


Val Thr Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys 
        115                 120                 125             


Met Glu Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Lys Gln Val Ile 
    130                 135                 140                 


Asp Lys Gly Gln Thr Ile Pro Glu Asp Ile Leu Gly Lys Ile Ala Val 
145                 150                 155                 160 


Ser Ile Val Lys Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile 
                165                 170                 175     


His Arg Asp Val Lys Pro Ser Asn Val Leu Ile Asn Ala Leu Gly Gln 
            180                 185                 190         


Val Lys Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val 
        195                 200                 205             


Ala Lys Thr Ile Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg 
    210                 215                 220                 


Ile Asn Pro Glu Leu Asn Gln Lys Gly Tyr Ser Val Lys Ser Asp Ile 
225                 230                 235                 240 


Trp Ser Leu Gly Ile Thr Met Ile Glu Leu Ala Ile Leu Arg Phe Pro 
                245                 250                 255     


Tyr Asp Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu 
            260                 265                 270         


Glu Pro Ser Pro Gln Leu Pro Ala Asp Lys Phe Ser Ala Glu Phe Val 
        275                 280                 285             


Asp Phe Thr Ser Gln Cys Leu Lys Lys Asn Ser Lys Glu Arg Pro Thr 
    290                 295                 300                 


Tyr Pro Glu Leu Met Gln His Pro Phe Phe Thr Leu His Glu Ser Lys 
305                 310                 315                 320 


Gly Thr Asp Val Ala Ser Phe Val Lys Leu Ile Leu Gly Asp 
                325                 330                 


<210>  139
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp 
    290                 295                 300                 


Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro 
305                 310                 315                 320 


Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr 
                325                 330                 335     


Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe 
            340                 345                 350         


Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp 
        355                 360                 365             


Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro 
    370                 375                 380                 


Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala 
385                 390                 395                 400 


Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly 
                405                 410                 415     


Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser 
            420                 425                 430         


Thr 
    


<210>  140
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Leu Ala Arg Arg Lys Pro Val Leu Pro Ala Leu Thr Ile Asn Pro 
1               5                   10                  15      


Thr Ile Ala Glu Gly Pro Ser Pro Thr Ser Glu Gly Ala Ser Glu Ala 
            20                  25                  30          


Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu 
        35                  40                  45              


Gln Gln Lys Lys Arg Leu Glu Ala Phe Leu Thr Gln Lys Ala Lys Val 
    50                  55                  60                  


Gly Glu Leu Lys Asp Asp Asp Phe Glu Arg Ile Ser Glu Leu Gly Ala 
65                  70                  75                  80  


Gly Asn Gly Gly Val Val Thr Lys Val Gln His Arg Pro Ser Gly Leu 
                85                  90                  95      


Ile Met Ala Arg Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg 
            100                 105                 110         


Asn Gln Ile Ile Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro 
        115                 120                 125             


Tyr Ile Val Gly Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser 
    130                 135                 140                 


Ile Cys Met Glu His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys 
145                 150                 155                 160 


Glu Ala Lys Arg Ile Pro Glu Glu Ile Leu Gly Lys Val Ser Ile Ala 
                165                 170                 175     


Val Leu Arg Gly Leu Ala Tyr Leu Arg Glu Lys His Gln Ile Met His 
            180                 185                 190         


Arg Asp Val Lys Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile 
        195                 200                 205             


Lys Leu Cys Asp Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala 
    210                 215                 220                 


Asn Ser Phe Val Gly Thr Arg Ser Tyr Met Ala Pro Glu Arg Leu Gln 
225                 230                 235                 240 


Gly Thr His Tyr Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser 
                245                 250                 255     


Leu Val Glu Leu Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala 
            260                 265                 270         


Lys Glu Leu Glu Ala Ile Phe Gly Arg Pro Val Val Asp Gly Glu Glu 
        275                 280                 285             


Gly Glu Pro His Ser Ile Ser Pro Arg Pro Arg Pro Pro Gly Arg Pro 
    290                 295                 300                 


Val Ser Gly His Gly Met Asp Ser Arg Pro Ala Met Ala Ile Phe Glu 
305                 310                 315                 320 


Leu Leu Asp Tyr Ile Val Asn Glu Pro Pro Pro Lys Leu Pro Asn Gly 
                325                 330                 335     


Val Phe Thr Pro Asp Phe Gln Glu Phe Val Asn Lys Cys Leu Ile Lys 
            340                 345                 350         


Asn Pro Ala Glu Arg Ala Asp Leu Lys Met Leu Thr Asn His Thr Phe 
        355                 360                 365             


Ile Lys Arg Ser Glu Val Glu Glu Val Asp Phe Ala Gly Trp Leu Cys 
    370                 375                 380                 


Lys Thr Leu Arg Leu Asn Gln Pro Gly Thr Pro Thr Arg Thr Ala Val 
385                 390                 395                 400 


<210>  141
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 
    130                 135                 140                 


Cys Ala Gln Asn Trp Ile Tyr Glu 
145                 150         


<210>  142
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Ser Asn Ile Cys Gln Arg Leu Trp Glu Tyr Leu Glu Pro Tyr Leu 
1               5                   10                  15      


Pro Cys Leu Ser Thr Glu Ala Asp Lys Ser Thr Val Ile Glu Asn Pro 
            20                  25                  30          


Gly Ala Leu Cys Ser Pro Gln Ser Gln Arg His Gly His Tyr Phe Val 
        35                  40                  45              


Ala Leu Phe Asp Tyr Gln Ala Arg Thr Ala Glu Asp Leu Ser Phe Arg 
    50                  55                  60                  


Ala Gly Asp Lys Leu Gln Val Leu Asp Thr Leu His Glu Gly Trp Trp 
65                  70                  75                  80  


Phe Ala Arg His Leu Glu Lys Arg Arg Asp Gly Ser Ser Gln Gln Leu 
                85                  90                  95      


Gln Gly Tyr Ile Pro Ser Asn Tyr Val Ala Glu Asp Arg Ser Leu Gln 
            100                 105                 110         


Ala Glu Pro Trp Phe Phe Gly Ala Ile Gly Arg Ser Asp Ala Glu Lys 
        115                 120                 125             


Gln Leu Leu Tyr Ser Glu Asn Lys Thr Gly Ser Phe Leu Ile Arg Glu 
    130                 135                 140                 


Ser Glu Ser Gln Lys Gly Glu Phe Ser Leu Ser Val Leu Asp Gly Ala 
145                 150                 155                 160 


Val Val Lys His Tyr Arg Ile Lys Arg Leu Asp Glu Gly Gly Phe Phe 
                165                 170                 175     


Leu Thr Arg Arg Arg Ile Phe Ser Thr Leu Asn Glu Phe Val Ser His 
            180                 185                 190         


Tyr Thr Lys Thr Ser Asp Gly Leu Cys Val Lys Leu Gly Lys Pro Cys 
        195                 200                 205             


Leu Lys Ile Gln Val Pro Ala Pro Phe Asp Leu Ser Tyr Lys Thr Val 
    210                 215                 220                 


Asp Gln Trp Glu Ile Asp Arg Asn Ser Ile Gln Leu Leu Lys Arg Leu 
225                 230                 235                 240 


Gly Ser Gly Gln Phe Gly Glu Val Trp Glu Gly Leu Trp Asn Asn Thr 
                245                 250                 255     


Thr Pro Val Ala Val Lys Thr Leu Lys Pro Gly Ser Met Asp Pro Asn 
            260                 265                 270         


Asp Phe Leu Arg Glu Ala Gln Ile Met Lys Asn Leu Arg His Pro Lys 
        275                 280                 285             


Leu Ile Gln Leu Tyr Ala Val Cys Thr Leu Glu Asp Pro Ile Tyr Ile 
    290                 295                 300                 


Ile Thr Glu Leu Met Arg His Gly Ser Leu Gln Glu Tyr Leu Gln Asn 
305                 310                 315                 320 


Asp Thr Gly Ser Lys Ile His Leu Thr Gln Gln Val Asp Met Ala Ala 
                325                 330                 335     


Gln Val Ala Ser Gly Met Ala Tyr Leu Glu Ser Arg Asn Tyr Ile His 
            340                 345                 350         


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu His Asn Ile Tyr 
        355                 360                 365             


Lys Val Ala Asp Phe Gly Leu Ala Arg Val Phe Lys Val Asp Asn Glu 
    370                 375                 380                 


Asp Ile Tyr Glu Ser Arg His Glu Ile Lys Leu Pro Val Lys Trp Thr 
385                 390                 395                 400 


Ala Pro Glu Ala Ile Arg Ser Asn Lys Phe Ser Ile Lys Ser Asp Val 
                405                 410                 415     


Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Ile Thr Tyr Gly Lys Met 
            420                 425                 430         


Pro Tyr Ser Gly Met Thr Gly Ala Gln Val Ile Gln Met Leu Ala Gln 
        435                 440                 445             


Asn Tyr Arg Leu Pro Gln Pro Ser Asn Cys Pro Gln Gln Phe Tyr Asn 
    450                 455                 460                 


Ile Met Leu Glu Cys Trp Asn Ala Glu Pro Lys Glu Arg Pro Thr Phe 
465                 470                 475                 480 


Glu Thr Leu Arg Trp Lys Leu Glu Asp Tyr Phe Glu Thr Asp Ser Ser 
                485                 490                 495     


Tyr Ser Asp Ala Asn Asn Phe Ile Arg 
            500                 505 


<210>  143
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Gly Leu Val Ser Ser Lys Lys Pro Asp Lys Glu Lys Pro Ile Lys 
1               5                   10                  15      


Glu Lys Asp Lys Gly Gln Trp Ser Pro Leu Lys Val Ser Ala Gln Asp 
            20                  25                  30          


Lys Asp Ala Pro Pro Leu Pro Pro Leu Val Val Phe Asn His Leu Thr 
        35                  40                  45              


Pro Pro Pro Pro Asp Glu His Leu Asp Glu Asp Lys His Phe Val Val 
    50                  55                  60                  


Ala Leu Tyr Asp Tyr Thr Ala Met Asn Asp Arg Asp Leu Gln Met Leu 
65                  70                  75                  80  


Lys Gly Glu Lys Leu Gln Val Leu Lys Gly Thr Gly Asp Trp Trp Leu 
                85                  90                  95      


Ala Arg Ser Leu Val Thr Gly Arg Glu Gly Tyr Val Pro Ser Asn Phe 
            100                 105                 110         


Val Ala Arg Val Glu Ser Leu Glu Met Glu Arg Trp Phe Phe Arg Ser 
        115                 120                 125             


Gln Gly Arg Lys Glu Ala Glu Arg Gln Leu Leu Ala Pro Ile Asn Lys 
    130                 135                 140                 


Ala Gly Ser Phe Leu Ile Arg Glu Ser Glu Thr Asn Lys Gly Ala Phe 
145                 150                 155                 160 


Ser Leu Ser Val Lys Asp Val Thr Thr Gln Gly Glu Leu Ile Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Cys Leu Asp Glu Gly Gly Tyr Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ile Thr Phe Pro Ser Leu Gln Ala Leu Val Gln His Tyr Ser Lys Lys 
        195                 200                 205             


Gly Asp Gly Leu Cys Gln Arg Leu Thr Leu Pro Cys Val Arg Pro Ala 
    210                 215                 220                 


Pro Gln Asn Pro Trp Ala Gln Asp Glu Trp Glu Ile Pro Arg Gln Ser 
225                 230                 235                 240 


Leu Arg Leu Val Arg Lys Leu Gly Ser Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Gly Tyr Tyr Lys Asn Asn Met Lys Val Ala Ile Lys Thr Leu Lys 
            260                 265                 270         


Glu Gly Thr Met Ser Pro Glu Ala Phe Leu Gly Glu Ala Asn Val Met 
        275                 280                 285             


Lys Ala Leu Gln His Glu Arg Leu Val Arg Leu Tyr Ala Val Val Thr 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Ala Arg Gly Cys Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Thr Asp Glu Gly Ser Arg Leu Ser Leu Pro Arg 
                325                 330                 335     


Leu Ile Asp Met Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr Ile Glu 
            340                 345                 350         


Arg Met Asn Ser Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Glu Ala Leu Cys Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Ile 
    370                 375                 380                 


Ile Asp Ser Glu Tyr Thr Ala Gln Glu Gly Ala Lys Phe Pro Ile Lys 
385                 390                 395                 400 


Trp Thr Ala Pro Glu Ala Ile His Phe Gly Val Phe Thr Ile Lys Ala 
                405                 410                 415     


Asp Val Trp Ser Phe Gly Val Leu Leu Met Glu Val Val Thr Tyr Gly 
            420                 425                 430         


Arg Val Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Asn Leu 
        435                 440                 445             


Glu Arg Gly Tyr Arg Met Pro Arg Pro Asp Thr Cys Pro Pro Glu Leu 
    450                 455                 460                 


Tyr Arg Gly Val Ile Ala Glu Cys Trp Arg Ser Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Thr Phe Glu Phe Leu Gln Ser Val Leu Glu Asp Phe Tyr Thr Ala 
                485                 490                 495     


Thr Glu Arg Gln Tyr Glu Leu Gln Pro 
            500                 505 


<210>  144
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu Cys Val Gly 
1               5                   10                  15      


Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val Ser Pro Asp 
            20                  25                  30          


Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys Asn Gln Tyr 
        35                  40                  45              


Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys Thr Tyr Cys 
    50                  55                  60                  


Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala Lys Cys Ser 
65                  70                  75                  80  


Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg Ser Lys Val 
                85                  90                  95      


Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg Gln Leu Ile 
            100                 105                 110         


Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe Cys Arg Ala 
        115                 120                 125             


Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly Asp Pro Leu 
    130                 135                 140                 


Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala Glu Pro Ile 
145                 150                 155                 160 


Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys Gln Pro Glu 
                165                 170                 175     


Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln Leu His Thr 
            180                 185                 190         


Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala Leu Met Lys 
        195                 200                 205             


Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val Ile Arg Val 
    210                 215                 220                 


Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser Ile Met Met 
225                 230                 235                 240 


Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn Ile Gln Gly 
                245                 250                 255     


Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg His Asp Gly 
            260                 265                 270         


Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln Pro Pro Trp 
        275                 280                 285             


Lys Val Leu Ser Asp Phe Ala Leu Gln Ser Asp Ile Asp Gln Pro Ala 
    290                 295                 300                 


Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro Asp Thr Pro 
                325                 330                 335     


Asn Ser Met Val Ala Ser Pro Ile Glu Ala 
            340                 345     


<210>  145
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  146
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Pro Pro Met Pro Val Ala Ser Val Ala Pro Ser Ala Ser Met Pro 
1               5                   10                  15      


Gly Ser His Leu Pro Pro Leu Tyr Leu Asp Gly His Val Phe Ala Ser 
            20                  25                  30          


Gln Pro Arg Leu Val Pro Gln Thr Ile Pro Gln Gln Gln Ser Tyr Gln 
        35                  40                  45              


Gln Ala Ala Ala Ala Gln Gln Ile Pro Ile Ser Leu His Thr Ser Leu 
    50                  55                  60                  


Gln Ala Gln Ala Gln Leu Gly Leu Arg Gly Gly Leu Pro Val Ser Gln 
65                  70                  75                  80  


Ser Gln Glu Ile Phe Ser Ser Leu Gln Pro Phe Arg Ser Gln Val Tyr 
                85                  90                  95      


Met His Pro Ser Leu Ser Pro Pro Ser Thr Met Ile Leu Ser Gly Gly 
            100                 105                 110         


Thr Ala Leu Lys Pro Pro Tyr Ser Ala Phe Pro Gly Met Gln Pro Leu 
        115                 120                 125             


Glu Met Val Lys Pro Gln Ser Gly Ser Pro Tyr Gln Pro Met Ser Gly 
    130                 135                 140                 


Asn Gln Ala Leu Val Tyr Glu Gly Gln Leu Ser Gln Ala Ala Gly Leu 
145                 150                 155                 160 


Gly Ala Ser Gln Met Leu Asp Ser Gln Leu Pro Gln Leu Thr Met Pro 
                165                 170                 175     


Leu Pro Arg Tyr Gly Ser Gly Gln Gln Pro Leu Ile Leu Pro Gln Ser 
            180                 185                 190         


Ile Gln Leu Pro Pro Gly Gln Ser Leu Ser Val Gly Ala Pro Arg Arg 
        195                 200                 205             


Ile Pro Pro Pro Gly Ser Gln Pro Pro Val Leu Asn Thr Ser Arg Glu 
    210                 215                 220                 


Pro Ser Gln Met Glu Met Lys Gly Phe His Phe Ala Asp Ser Lys Gln 
225                 230                 235                 240 


Asn Val Pro Ser Gly Gly Pro Val Pro Ser Pro Gln Thr Tyr Arg Pro 
                245                 250                 255     


Ser Ser Ala Ser Pro Ser Gly Lys Pro Ser Gly Ser Ala Val Asn Met 
            260                 265                 270         


Gly Ser Val Gln Gly His Tyr Val Gln Gln Ala Lys Gln Arg Val Asp 
        275                 280                 285             


Glu Lys Pro Ser Leu Gly Ala Val Lys Leu Gln Glu Ala Pro Ser Ala 
    290                 295                 300                 


Ala Ser Gln Met Lys Arg Thr Gly Ala Ile Lys Pro Arg Ala Val Lys 
305                 310                 315                 320 


Val Glu Glu Ser Lys Ala 
                325     


<210>  147
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Gly Glu Pro Ala Gly Val Ala Gly Thr Met Glu Ser Pro Phe Ser 
1               5                   10                  15      


Pro Gly Leu Phe His Arg Leu Asp Glu Asp Trp Asp Ser Ala Leu Phe 
            20                  25                  30          


Ala Glu Leu Gly Tyr Phe Thr Asp Thr Asp Glu Leu Gln Leu Glu Ala 
        35                  40                  45              


Ala Asn Glu Thr Tyr Glu Asn Asn Phe Asp Asn Leu Asp Phe Asp Leu 
    50                  55                  60                  


Asp Leu Val Pro Trp Glu Ser Asp Ile Trp Asp Ile Asn Asn Gln Ile 
65                  70                  75                  80  


Cys Thr Val Lys Asp Ile Lys Ala Glu Pro Gln Pro Leu Ser Pro Ala 
                85                  90                  95      


Ser Ser Ser Tyr Ser Val Ser Ser Pro Arg Ser Val Asp Ser Tyr Ser 
            100                 105                 110         


Ser Thr Gln His Val Pro Glu Glu Leu Asp Leu Ser Ser Ser Ser Gln 
        115                 120                 125             


Met Ser Pro Leu Ser Leu Tyr Gly Glu Asn Ser Asn Ser Leu Ser Ser 
    130                 135                 140                 


Ala Glu Pro Leu Lys Glu Asp Lys Pro Val Thr Gly Pro Arg Asn Lys 
145                 150                 155                 160 


Thr Glu Asn Gly Leu Thr Pro Lys Lys Lys Ile Gln Val Asn Ser Lys 
                165                 170                 175     


Pro Ser Ile Gln Pro Lys Pro Leu Leu Leu Pro Ala Ala Pro Lys Thr 
            180                 185                 190         


Gln Thr Ile Ser Ser Ile Pro Pro Gln Thr 
        195                 200         


<210>  148
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Gln Lys Glu Ser Gln Ile Asp Val Leu Gln Gln Asp Glu Leu Asp 
1               5                   10                  15      


Ser Tyr Pro Asp Ser Val Lys Lys Glu Asn Lys Asn Pro Val Asn Asn 
            20                  25                  30          


Leu Ile Arg Lys Asp Tyr Leu Glu Glu Pro Glu Lys Thr Gln Trp Asn 
        35                  40                  45              


Asn Val Glu Asn Leu Asn Arg Phe Glu Arg Pro Met Asp Tyr Tyr Glu 
    50                  55                  60                  


Asp Leu Lys Met Gly Met Lys Phe Val Ser Asp Glu His Tyr Asp Glu 
65                  70                  75                  80  


Asn Glu Asp Asp Leu Val Ser His Val Asp Gly Ser Val Ile Ser Arg 
                85                  90                  95      


Arg Glu Trp Tyr Val 
            100     


<210>  149
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Ile Pro Pro Ser Ser Pro Arg Glu Asp Gly Val Asp Gly Leu Pro 
1               5                   10                  15      


Lys Glu Ala Val Gly Ala Glu Gln Pro Pro Ser Pro Ala Ser Thr Ser 
            20                  25                  30          


Ser Gln Glu Ser Lys Leu Gln Lys Leu Lys Arg Ser Leu Ser Phe Lys 
        35                  40                  45              


Thr Lys Ser Leu Arg Ser Lys Ser Ala Asp Asn Phe Phe Gln Arg Thr 
    50                  55                  60                  


Asn Ser Glu Asp Met Lys Leu Gln Ala His Met Val Ala Glu Ile Ser 
65                  70                  75                  80  


Pro Ser Ser Ser Pro Leu Pro Ala Pro Gly Ser Leu Thr Ser Thr Pro 
                85                  90                  95      


Ala Arg Ala Gly Leu His Pro Gly Gly Lys Ala His Ala Phe His Glu 
            100                 105                 110         


Tyr Ile Phe Lys Lys Pro Thr Phe Cys Asp Val Cys Asn His Met Ile 
        115                 120                 125             


Val Gly Thr Asn Ala Lys His Gly Leu Arg Cys Lys Ala Cys Lys Met 
    130                 135                 140                 


Ser Ile His His Lys Cys Thr Asp Gly Leu Ala Pro Gln Arg Cys Met 
145                 150                 155                 160 


Gly Lys Leu Pro Lys Gly Phe Arg Arg Tyr Tyr Ser Ser Pro Leu Leu 
                165                 170                 175     


Ile His Glu Gln Phe Gly Cys Ile Lys Glu Val Met Pro Ile Ala Cys 
            180                 185                 190         


Gly Asn Lys Val Asp Pro Val Tyr Glu Thr Leu Arg Phe Gly Thr Ser 
        195                 200                 205             


Leu Ala Gln Arg Thr Lys Lys Gly Ser Ser Gly Ser Gly Ser Asp Ser 
    210                 215                 220                 


Pro His Arg Thr Ser Thr Ser Asp Leu Val Glu Val Pro Glu Glu Ala 
225                 230                 235                 240 


Asn Gly Pro Gly Gly Gly Tyr Asp Leu Arg Lys Arg Ser Asn Ser Val 
                245                 250                 255     


Phe Thr Tyr Pro Glu Asn Gly Thr Asp Asp Phe Arg Asp Pro Ala Lys 
            260                 265                 270         


Asn Ile Asn His Gln Gly Ser Leu Ser Lys Asp Pro Leu Gln Met Asn 
        275                 280                 285             


Thr Tyr Val Ala Leu Tyr Lys Phe Val Pro Gln Glu Asn Glu Asp Leu 
    290                 295                 300                 


Glu Met Arg Pro Gly Asp Ile Ile Thr Leu Leu Glu Asp Ser Asn Glu 
305                 310                 315                 320 


Asp Trp Trp Lys Gly Lys Ile Gln Asp Arg Ile Gly Phe Phe Pro Ala 
                325                 330                 335     


Asn Phe Val Gln Arg Leu Gln Gln Asn Glu Lys Ile Phe Arg Cys Val 
            340                 345                 350         


Arg Thr Phe Ile Gly Cys Lys Glu Gln Gly Gln Ile Thr Leu Lys Glu 
        355                 360                 365             


Asn Gln Ile Cys Val Ser Ser Glu Glu Glu Gln Asp Gly Phe Ile Arg 
    370                 375                 380                 


Val Leu Ser Gly Lys Lys Lys Gly Leu Ile Pro Leu Asp Val Leu Glu 
385                 390                 395                 400 


Asn Ile 
        


<210>  150
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Arg Gly Ala Met Glu Leu Glu Pro Glu Leu Leu Leu Gln Glu Ala 
1               5                   10                  15      


Arg Glu Asn Val Glu Ala Ala Gln Ser Tyr Arg Arg Glu Leu Gly His 
            20                  25                  30          


Arg Leu Glu Gly Leu Arg Glu Ala Arg Arg Gln Ile Lys Glu Ser Ala 
        35                  40                  45              


Ser Gln Thr Arg Asp Val Leu Lys Gln His Phe Asn Asp Leu Lys Gly 
    50                  55                  60                  


Thr Leu Gly Lys Leu Leu Asp Glu Arg Leu Val Thr Leu Leu Gln Glu 
65                  70                  75                  80  


Val Asp Thr Ile Glu Gln Glu Thr Ile Lys Pro Leu Asp Asp Cys Gln 
                85                  90                  95      


Lys Leu Ile Glu His Gly Val Asn Thr Ala Glu Asp Leu Val Arg Glu 
            100                 105                 110         


Gly Glu Ile Ala Met Leu Gly Gly Val Gly Glu Glu Asn Glu Lys Leu 
        115                 120                 125             


Trp Ser Phe Thr Lys Lys Ala Ser His Ile Gln Leu Asp Ser Leu Pro 
    130                 135                 140                 


Glu Val Pro Leu Leu Val Asp Val Pro Cys Leu Ser Ala Gln Leu Asp 
145                 150                 155                 160 


Asp Ser Ile Leu Asn Ile Val Lys Asp His Ile Phe Lys His Gly Thr 
                165                 170                 175     


Val Ala Ser Arg Pro Pro Val Gln Ile Glu Glu Leu Ile Glu Lys Pro 
            180                 185                 190         


Gly Gly Ile Ile Val Arg Trp Cys Lys Val Asp Asp Asp Phe Thr Ala 
        195                 200                 205             


Gln Asp Tyr Arg Leu Gln Phe Arg Lys Cys Thr Ser Asn His Phe Glu 
    210                 215                 220                 


Asp Val Tyr Val Gly Ser Glu Thr Glu Phe Ile Val Leu His Ile Asp 
225                 230                 235                 240 


Pro Asn Val Asp Tyr Gln Phe Arg Val Cys Ala Arg Gly Asp Gly Arg 
                245                 250                 255     


Gln Glu Trp Ser Pro Trp Ser Val Pro Gln Ile Gly His Ser Thr Leu 
            260                 265                 270         


Val Pro His Glu Trp Thr Ala Gly Phe Glu Gly Tyr Ser Leu Ser Ser 
        275                 280                 285             


Arg Arg Asn Ile Ala Leu Arg Asn Asp Ser Glu Ser Ser Gly Val Leu 
    290                 295                 300                 


Tyr Ser Arg Ala Pro Thr Tyr Phe Cys Gly Gln Thr Leu Thr Phe Arg 
305                 310                 315                 320 


Val Glu Thr Val Gly Gln Pro Asp Arg Arg Asp Ser Ile Gly Val Cys 
                325                 330                 335     


Ala Glu Lys Gln Asp Gly Tyr Asp Ser Leu Gln Arg Asp Gln Ala Val 
            340                 345                 350         


Cys Ile Ser Thr Asn Gly Ala Val Phe Val Asn Gly Lys Glu Met Thr 
        355                 360                 365             


Asn Gln Leu Pro Ala Val Thr Ser Gly Ser Thr Val Thr Phe Asp Ile 
    370                 375                 380                 


Glu Ala Val Thr Leu Gly Thr Thr Ser Asn Asn Glu Gly Gly His Phe 
385                 390                 395                 400 


Lys Leu Arg Val Thr Ile Ser Ser Asn Asn Arg Glu Val Val Phe Asp 
                405                 410                 415     


Trp Leu Leu Asp Gln Ser Cys Gly Ser Leu Tyr Phe Gly Cys Ser Phe 
            420                 425                 430         


Phe Tyr Pro Gly Trp Lys Val Leu Val Phe 
        435                 440         


<210>  151
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Gly Asp Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu 
1               5                   10                  15      


Cys Val Gly Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val 
            20                  25                  30          


Ser Pro Asp Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys 
        35                  40                  45              


Asn Gln Tyr Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys 
    50                  55                  60                  


Thr Tyr Cys Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala 
65                  70                  75                  80  


Lys Cys Ser Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg 
                85                  90                  95      


Ser Lys Val Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg 
            100                 105                 110         


Gln Leu Ile Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe 
        115                 120                 125             


Cys Arg Ala Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly 
    130                 135                 140                 


Asp Pro Leu Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala 
145                 150                 155                 160 


Glu Pro Ile Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys 
                165                 170                 175     


Gln Pro Glu Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln 
            180                 185                 190         


Leu His Thr Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala 
        195                 200                 205             


Leu Met Lys Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val 
    210                 215                 220                 


Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser 
225                 230                 235                 240 


Ile Met Met Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn 
                245                 250                 255     


Ile Gln Gly Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg 
            260                 265                 270         


His Asp Gly Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln 
        275                 280                 285             


Pro Pro Trp Lys Val Leu Ser Asp Phe Ala Leu Gln Ser Asp Ile Asp 
    290                 295                 300                 


Gln Pro Ala Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly 
305                 310                 315                 320 


Ser Asn Ser Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro 
                325                 330                 335     


Asp Thr Pro Asn Ser Met Val Ala Ser Pro Ile Glu Ala 
            340                 345                 


<210>  152
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Arg Pro Gly Leu Pro Gly Pro Thr Gly Leu Cys Ala Gln Thr Ser 
1               5                   10                  15      


Ser Arg Gly Gln Lys Ser Val Leu Lys Gln Lys Glu Ser Cys Gly Ile 
            20                  25                  30          


Trp Gln Leu Tyr His Phe Leu Ser Arg Lys Gln Glu Pro Arg Trp Glu 
        35                  40                  45              


Pro Cys Val Ser Gly Ser Ser Ser Gly Asp Gly Ala Val Ala Asp Leu 
    50                  55                  60                  


Ala Asp Glu Leu Arg Gly Tyr Pro Ala Leu Cys Cys Thr Leu Pro Val 
65                  70                  75                  80  


His Ser Tyr Arg Ser Trp Ala Gly Ile Arg Pro Gln Ile Met Asn Gly 
                85                  90                  95      


Pro Leu His Pro Arg Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys 
            100                 105                 110         


Thr Val Glu Met Pro Ile Leu Lys Asp Leu Ala Thr Val Ala Phe Cys 
        115                 120                 125             


Asp Ala Gln Ser Thr Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala 
    130                 135                 140                 


Val Gly Ala Met Met Tyr His Thr Ile Thr Leu Thr Arg Glu Asp Leu 
145                 150                 155                 160 


Glu Lys Phe Lys Ala Leu Arg Val Ile Val Arg Ile Gly Ser Gly Tyr 
                165                 170                 175     


Asp Asn Val Asp Ile Lys Ala Ala Gly Glu Leu Gly Ile Ala Val Cys 
            180                 185                 190         


Asn Ile Pro Ser Ala Ala Val Glu Glu Thr Ala Asp Ser Thr Ile Cys 
        195                 200                 205             


His Ile Leu Asn Leu Tyr Arg Arg Asn Thr Trp Leu Tyr Gln Ala Leu 
    210                 215                 220                 


Arg Glu Gly Thr Arg Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala 
225                 230                 235                 240 


Ser Gly Ala Ala Arg Ile Arg Gly Glu Thr Leu Gly Leu Ile Gly Phe 
                245                 250                 255     


Gly Arg Thr Gly Gln Ala Val Ala Val Arg Ala Lys Ala Phe Gly Phe 
            260                 265                 270         


Ser Val Ile Phe Tyr Asp Pro Tyr Leu Gln Asp Gly Ile Glu Arg Ser 
        275                 280                 285             


Leu Gly Val Gln Arg Val Tyr Thr Leu Gln Asp Leu Leu Tyr Gln Ser 
    290                 295                 300                 


Asp Cys Val Ser Leu His Cys Asn Leu Asn Glu His Asn His His Leu 
305                 310                 315                 320 


Ile Asn Asp Phe Thr Ile Lys Gln Met Arg Gln Gly Ala Phe Leu Val 
                325                 330                 335     


Asn Ala Ala Arg Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala 
            340                 345                 350         


Leu Lys Glu Gly Arg Ile Arg Arg Ala Ala Leu Asp Val His Glu Ser 
        355                 360                 365             


Glu Pro Phe Ser Phe Ala Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu 
    370                 375                 380                 


Ile Cys Thr Pro His Thr Ala Trp Tyr Ser Glu Gln Ala Ser Leu Glu 
385                 390                 395                 400 


Met Arg Glu Ala Ala Ala Thr Glu Ile Arg Arg Ala Ile Thr Gly Arg 
                405                 410                 415     


Ile Pro Glu Ser Leu Arg Asn Cys Val Asn Lys Glu Phe Phe Val Thr 
            420                 425                 430         


Ser Ala Pro Trp Ser Val Ile Asp Gln Gln Ala Ile His Pro Glu Leu 
        435                 440                 445             


Asn Gly Ala Thr Tyr Arg Tyr Pro Pro Gly Ile Val Gly Val Ala Pro 
    450                 455                 460                 


Gly Gly Leu Pro Ala Ala Met Glu Gly Ile Ile Pro Gly Gly Ile Pro 
465                 470                 475                 480 


Val Thr His Asn Leu Pro Thr Val Ala His Pro Ser Gln Ala Pro Ser 
                485                 490                 495     


Pro Asn Gln Pro Thr Lys His Gly Asp Asn Arg Glu His Pro Asn Glu 
            500                 505                 510         


Gln 
    


<210>  153
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Thr Asp Ser Ser Lys Thr Asp Thr Leu Asn Ser Ser Ser Ser Gly 
1               5                   10                  15      


Thr Thr Ala Ser Ser Leu Glu Lys Ile Lys Val Gln Ala Asn Ala Pro 
            20                  25                  30          


Leu Ile Lys Pro Pro Ala His Thr Ser Ala Ile Leu Thr Val Leu Arg 
        35                  40                  45              


Lys Pro Asn Pro Pro Pro Pro Pro Pro Arg Leu Thr Pro Val Lys Cys 
    50                  55                  60                  


Glu Asp Pro Lys Arg Val Val Pro Thr Ala Asn Pro Val Lys Thr Asn 
65                  70                  75                  80  


Gly Thr Leu Leu Arg Asn Gly Gly Leu Pro Gly Gly Pro Asn Lys Ile 
                85                  90                  95      


Pro Asn Gly Asp Ile Cys Cys Ile Pro Asn Ser Asn Leu Asp Lys Ala 
            100                 105                 110         


Pro Val Gln Leu Leu Met His Arg Pro Glu Lys Asp Arg Cys Pro Gln 
        115                 120                 125             


Ala Gly Pro Arg Glu Arg Val Arg Phe Asn Glu Lys Val Gln Tyr His 
    130                 135                 140                 


Gly Tyr Cys Pro Asp Cys Asp Thr Arg Tyr Asn Ile Lys Asn Arg Glu 
145                 150                 155                 160 


Val His Leu His Ser Glu Pro Val His Pro Pro Gly Lys Ile Pro His 
                165                 170                 175     


Gln Gly Pro Pro Leu Pro Pro Thr Pro His Leu Pro Pro Phe Pro Leu 
            180                 185                 190         


Glu Asn Gly Gly Met Gly Ile Ser His Ser Asn Ser Phe Pro Pro Ile 
        195                 200                 205             


Arg Pro Ala Thr Val Pro Pro Pro Thr Ala Pro Lys Pro Gln Lys Thr 
    210                 215                 220                 


Ile Leu Arg Lys Ser Thr Thr Thr Thr Val 
225                 230                 


<210>  154
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ala Ala Ser Ser Ser Glu Ile Ser Glu Met Lys Gly Val Glu Glu 
1               5                   10                  15      


Ser Pro Lys Val Pro Gly Glu Gly Pro Gly His Ser Glu Ala Glu Thr 
            20                  25                  30          


Gly Pro Pro Gln Val Leu Ala Gly Val Pro Asp Gln Pro Glu Ala Pro 
        35                  40                  45              


Gln Pro Gly Pro Asn Thr Thr Ala Ala Pro Val Asp Ser Gly Pro Lys 
    50                  55                  60                  


Ala Gly Leu Ala Pro Glu Thr Thr Glu Thr Pro Ala Gly Ala Ser Glu 
65                  70                  75                  80  


Thr Ala Gln Ala Thr Asp Leu Ser Leu Ser Pro Gly Gly Glu Ser Lys 
                85                  90                  95      


Ala Asn Cys Ser Pro Glu Asp Pro Cys Gln Glu Thr Val Ser Lys Pro 
            100                 105                 110         


Glu Val Ser Lys Glu Ala Thr Ala Asp Gln Gly Ser Arg Leu Glu Ser 
        115                 120                 125             


Ala Ala Pro Pro Glu Pro Ala Pro Glu Pro Ala Pro Gln Pro Asp Pro 
    130                 135                 140                 


Arg Pro Asp Ser Gln Pro Thr Pro Lys Pro Ala Leu Gln Pro Glu Leu 
145                 150                 155                 160 


Pro Thr Gln Glu Asp Pro Thr Pro Glu Ile Leu Ser Glu Ser Val Gly 
                165                 170                 175     


Glu Lys Gln Glu Asn Gly Ala Val Val Pro Leu Gln Ala Gly Asp Gly 
            180                 185                 190         


Glu Glu Gly Pro Ala Pro Glu Pro His Ser Pro Pro Ser Lys Lys Ser 
        195                 200                 205             


Pro Pro Ala Asn Gly Ala Pro Pro Arg Val Leu Gln Gln Leu Val Glu 
    210                 215                 220                 


Glu Asp Arg Met Arg Arg Ala His Ser Gly His Pro Gly Ser Pro Arg 
225                 230                 235                 240 


Gly Ser Leu Ser Arg His Pro Ser Ser Gln Leu Ala Gly Pro Gly Val 
                245                 250                 255     


Glu Gly Gly Glu Gly Thr Gln Lys Pro Arg Asp Tyr Ile Ile Leu Ala 
            260                 265                 270         


Ile Leu Ser Cys Phe Cys Pro Met Trp Pro Val Asn Ile Val Ala Phe 
        275                 280                 285             


Ala Tyr Ala Val Met Ser Arg Asn Ser Leu Gln Gln Gly Asp Val Asp 
    290                 295                 300                 


Gly Ala Gln Arg Leu Gly Arg Val Ala Lys Leu Leu Ser Ile Val Ala 
305                 310                 315                 320 


Leu Val Gly Gly Val Leu Ile Ile Ile Ala Ser Cys Val Ile Asn Leu 
                325                 330                 335     


Gly Val Tyr Lys 
            340 


<210>  155
<211>  1242
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Ala Ser Pro Pro Glu Ser Asp Gly Phe Ser Asp Val Arg Lys Val 
1               5                   10                  15      


Gly Tyr Leu Arg Lys Pro Lys Ser Met His Lys Arg Phe Phe Val Leu 
            20                  25                  30          


Arg Ala Ala Ser Glu Ala Gly Gly Pro Ala Arg Leu Glu Tyr Tyr Glu 
        35                  40                  45              


Asn Glu Lys Lys Trp Arg His Lys Ser Ser Ala Pro Lys Arg Ser Ile 
    50                  55                  60                  


Pro Leu Glu Ser Cys Phe Asn Ile Asn Lys Arg Ala Asp Ser Lys Asn 
65                  70                  75                  80  


Lys His Leu Val Ala Leu Tyr Thr Arg Asp Glu His Phe Ala Ile Ala 
                85                  90                  95      


Ala Asp Ser Glu Ala Glu Gln Asp Ser Trp Tyr Gln Ala Leu Leu Gln 
            100                 105                 110         


Leu His Asn Arg Ala Lys Gly His His Asp Gly Ala Ala Ala Leu Gly 
        115                 120                 125             


Ala Gly Gly Gly Gly Gly Ser Cys Ser Gly Ser Ser Gly Leu Gly Glu 
    130                 135                 140                 


Ala Gly Glu Asp Leu Ser Tyr Gly Asp Val Pro Pro Gly Pro Ala Phe 
145                 150                 155                 160 


Lys Glu Val Trp Gln Val Ile Leu Lys Pro Lys Gly Leu Gly Gln Thr 
                165                 170                 175     


Lys Asn Leu Ile Gly Ile Tyr Arg Leu Cys Leu Thr Ser Lys Thr Ile 
            180                 185                 190         


Ser Phe Val Lys Leu Asn Ser Glu Ala Ala Ala Val Val Leu Gln Leu 
        195                 200                 205             


Met Asn Ile Arg Arg Cys Gly His Ser Glu Asn Phe Phe Phe Ile Glu 
    210                 215                 220                 


Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Phe Trp Met Gln Val 
225                 230                 235                 240 


Asp Asp Ser Val Val Ala Gln Asn Met His Glu Thr Ile Leu Glu Ala 
                245                 250                 255     


Met Arg Ala Met Ser Asp Glu Phe Arg Pro Arg Ser Lys Ser Gln Ser 
            260                 265                 270         


Ser Ser Asn Cys Ser Asn Pro Ile Ser Val Pro Leu Arg Arg His His 
        275                 280                 285             


Leu Asn Asn Pro Pro Pro Ser Gln Val Gly Leu Thr Arg Arg Ser Arg 
    290                 295                 300                 


Thr Glu Ser Ile Thr Ala Thr Ser Pro Ala Ser Met Val Gly Gly Lys 
305                 310                 315                 320 


Pro Gly Ser Phe Arg Val Arg Ala Ser Ser Asp Gly Glu Gly Thr Met 
                325                 330                 335     


Ser Arg Pro Ala Ser Val Asp Gly Ser Pro Val Ser Pro Ser Thr Asn 
            340                 345                 350         


Arg Thr His Ala His Arg His Arg Gly Ser Ala Arg Leu His Pro Pro 
        355                 360                 365             


Leu Asn His Ser Arg Ser Ile Pro Met Pro Ala Ser Arg Cys Ser Pro 
    370                 375                 380                 


Ser Ala Thr Ser Pro Val Ser Leu Ser Ser Ser Ser Thr Ser Gly His 
385                 390                 395                 400 


Gly Ser Thr Ser Asp Cys Leu Phe Pro Arg Arg Ser Ser Ala Ser Val 
                405                 410                 415     


Ser Gly Ser Pro Ser Asp Gly Gly Phe Ile Ser Ser Asp Glu Tyr Gly 
            420                 425                 430         


Ser Ser Pro Cys Asp Phe Arg Ser Ser Phe Arg Ser Val Thr Pro Asp 
        435                 440                 445             


Ser Leu Gly His Thr Pro Pro Ala Arg Gly Glu Glu Glu Leu Ser Asn 
    450                 455                 460                 


Tyr Ile Cys Met Gly Gly Lys Gly Pro Ser Thr Leu Thr Ala Pro Asn 
465                 470                 475                 480 


Gly His Tyr Ile Leu Ser Arg Gly Gly Asn Gly His Arg Cys Thr Pro 
                485                 490                 495     


Gly Thr Gly Leu Gly Thr Ser Pro Ala Leu Ala Gly Asp Glu Ala Ala 
            500                 505                 510         


Ser Ala Ala Asp Leu Asp Asn Arg Phe Arg Lys Arg Thr His Ser Ala 
        515                 520                 525             


Gly Thr Ser Pro Thr Ile Thr His Gln Lys Thr Pro Ser Gln Ser Ser 
    530                 535                 540                 


Val Ala Ser Ile Glu Glu Tyr Thr Glu Met Met Pro Ala Tyr Pro Pro 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Arg Leu Pro Gly His Arg His Ser Ala Phe 
                565                 570                 575     


Val Pro Thr Arg Ser Tyr Pro Glu Glu Gly Leu Glu Met His Pro Leu 
            580                 585                 590         


Glu Arg Arg Gly Gly His His Arg Pro Asp Ser Ser Thr Leu His Thr 
        595                 600                 605             


Asp Asp Gly Tyr Met Pro Met Ser Pro Gly Val Ala Pro Val Pro Ser 
    610                 615                 620                 


Gly Arg Lys Gly Ser Gly Asp Tyr Met Pro Met Ser Pro Lys Ser Val 
625                 630                 635                 640 


Ser Ala Pro Gln Gln Ile Ile Asn Pro Ile Arg Arg His Pro Gln Arg 
                645                 650                 655     


Val Asp Pro Asn Gly Tyr Met Met Met Ser Pro Ser Gly Gly Cys Ser 
            660                 665                 670         


Pro Asp Ile Gly Gly Gly Pro Ser Ser Ser Ser Ser Ser Ser Asn Ala 
        675                 680                 685             


Val Pro Ser Gly Thr Ser Tyr Gly Lys Leu Trp Thr Asn Gly Val Gly 
    690                 695                 700                 


Gly His His Ser His Val Leu Pro His Pro Lys Pro Pro Val Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Lys Leu Leu Pro Cys Thr Gly Asp Tyr Met Asn Met Ser 
                725                 730                 735     


Pro Val Gly Asp Ser Asn Thr Ser Ser Pro Ser Asp Cys Tyr Tyr Gly 
            740                 745                 750         


Pro Glu Asp Pro Gln His Lys Pro Val Leu Ser Tyr Tyr Ser Leu Pro 
        755                 760                 765             


Arg Ser Phe Lys His Thr Gln Arg Pro Gly Glu Pro Glu Glu Gly Ala 
    770                 775                 780                 


Arg His Gln His Leu Arg Leu Ser Thr Ser Ser Gly Arg Leu Leu Tyr 
785                 790                 795                 800 


Ala Ala Thr Ala Asp Asp Ser Ser Ser Ser Thr Ser Ser Asp Ser Leu 
                805                 810                 815     


Gly Gly Gly Tyr Cys Gly Ala Arg Leu Glu Pro Ser Leu Pro His Pro 
            820                 825                 830         


His His Gln Val Leu Gln Pro His Leu Pro Arg Lys Val Asp Thr Ala 
        835                 840                 845             


Ala Gln Thr Asn Ser Arg Leu Ala Arg Pro Thr Arg Leu Ser Leu Gly 
    850                 855                 860                 


Asp Pro Lys Ala Ser Thr Leu Pro Arg Ala Arg Glu Gln Gln Gln Gln 
865                 870                 875                 880 


Gln Gln Pro Leu Leu His Pro Pro Glu Pro Lys Ser Pro Gly Glu Tyr 
                885                 890                 895     


Val Asn Ile Glu Phe Gly Ser Asp Gln Ser Gly Tyr Leu Ser Gly Pro 
            900                 905                 910         


Val Ala Phe His Ser Ser Pro Ser Val Arg Cys Pro Ser Gln Leu Gln 
        915                 920                 925             


Pro Ala Pro Arg Glu Glu Glu Thr Gly Thr Glu Glu Tyr Met Lys Met 
    930                 935                 940                 


Asp Leu Gly Pro Gly Arg Arg Ala Ala Trp Gln Glu Ser Thr Gly Val 
945                 950                 955                 960 


Glu Met Gly Arg Leu Gly Pro Ala Pro Pro Gly Ala Ala Ser Ile Cys 
                965                 970                 975     


Arg Pro Thr Arg Ala Val Pro Ser Ser Arg Gly Asp Tyr Met Thr Met 
            980                 985                 990         


Gln Met Ser Cys Pro Arg Gln Ser  Tyr Val Asp Thr Ser  Pro Ala Ala 
        995                 1000                 1005             


Pro Val  Ser Tyr Ala Asp Met  Arg Thr Gly Ile Ala  Ala Glu Glu 
    1010                 1015                 1020             


Val Ser  Leu Pro Arg Ala Thr  Met Ala Ala Ala Ser  Ser Ser Ser 
    1025                 1030                 1035             


Ala Ala  Ser Ala Ser Pro Thr  Gly Pro Gln Gly Ala  Ala Glu Leu 
    1040                 1045                 1050             


Ala Ala  His Ser Ser Leu Leu  Gly Gly Pro Gln Gly  Pro Gly Gly 
    1055                 1060                 1065             


Met Ser  Ala Phe Thr Arg Val  Asn Leu Ser Pro Asn  Arg Asn Gln 
    1070                 1075                 1080             


Ser Ala  Lys Val Ile Arg Ala  Asp Pro Gln Gly Cys  Arg Arg Arg 
    1085                 1090                 1095             


His Ser  Ser Glu Thr Phe Ser  Ser Thr Pro Ser Ala  Thr Arg Val 
    1100                 1105                 1110             


Gly Asn  Thr Val Pro Phe Gly  Ala Gly Ala Ala Val  Gly Gly Gly 
    1115                 1120                 1125             


Gly Gly  Ser Ser Ser Ser Ser  Glu Asp Val Lys Arg  His Ser Ser 
    1130                 1135                 1140             


Ala Ser  Phe Glu Asn Val Trp  Leu Arg Pro Gly Glu  Leu Gly Gly 
    1145                 1150                 1155             


Ala Pro  Lys Glu Pro Ala Lys  Leu Cys Gly Ala Ala  Gly Gly Leu 
    1160                 1165                 1170             


Glu Asn  Gly Leu Asn Tyr Ile  Asp Leu Asp Leu Val  Lys Asp Phe 
    1175                 1180                 1185             


Lys Gln  Cys Pro Gln Glu Cys  Thr Pro Glu Pro Gln  Pro Pro Pro 
    1190                 1195                 1200             


Pro Pro  Pro Pro His Gln Pro  Leu Gly Ser Gly Glu  Ser Ser Ser 
    1205                 1210                 1215             


Thr Arg  Arg Ser Ser Glu Asp  Leu Ser Ala Tyr Ala  Ser Ile Ser 
    1220                 1225                 1230             


Phe Gln  Lys Gln Pro Glu Asp  Arg Gln 
    1235                 1240         


<210>  156
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Gly Arg Lys Lys Ile Gln Ile Gln Arg Ile Thr Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn His Ser Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ala Asp Ile Ile Glu Thr Leu Arg Lys Lys Gly Phe Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Glu Pro Asp Gly Glu Asp Ser Leu Glu Gln Ser Pro Leu 
            100                 105                 110         


Leu Glu Asp Lys Tyr Arg Arg Ala Ser Glu Glu Leu Asp Gly Leu Phe 
        115                 120                 125             


Arg Arg Tyr Gly Ser Thr Val Pro Ala Pro Asn Phe Ala Met Pro Val 
    130                 135                 140                 


Thr Val Pro Val Ser Asn Gln Ser Ser Leu Gln Phe Ser Asn Pro Ser 
145                 150                 155                 160 


Gly Ser Leu Val Thr Pro Ser Leu Val Thr Ser Ser Leu Thr Asp Pro 
                165                 170                 175     


Arg Leu Leu Ser Pro Gln Gln Pro Ala Leu Gln Arg Asn Ser Val Ser 
            180                 185                 190         


Pro Gly Leu Pro Gln Arg Pro Ala Ser Ala Gly Ala Met Leu Gly Gly 
        195                 200                 205             


Asp Leu Asn Ser Ala Asn Gly Ala Cys Pro Ser Pro Val Gly Asn Gly 
    210                 215                 220                 


Tyr Val Ser Ala Arg Ala Ser Pro Gly Leu Leu Pro Val Ala Asn Gly 
225                 230                 235                 240 


Asn Ser Leu Asn Lys Val Ile Pro Ala Lys Ser Pro Pro Pro Pro Thr 
                245                 250                 255     


His Ser Thr Gln Leu Gly Ala Pro Ser Arg Lys Pro Asp Leu Arg Val 
            260                 265                 270         


Ile Thr Ser Gln Ala Gly Lys Gly Leu Met His His Leu Thr Glu Asp 
        275                 280                 285             


His Leu Asp Leu Asn Asn Ala Gln Arg Leu Gly Val Ser Gln Ser Thr 
    290                 295                 300                 


His Ser Leu Thr Thr Pro Val Val Ser Val Ala Thr Pro Ser Leu Leu 
305                 310                 315                 320 


Ser Gln Gly Leu Pro Phe Ser Ser Met Pro Thr Ala Tyr Asn Thr Asp 
                325                 330                 335     


Tyr Gln Leu Thr Ser Ala Glu Leu Ser Ser Leu Pro Ala Phe Ser Ser 
            340                 345                 350         


Pro Gly Gly Leu Ser Leu Gly Asn Val Thr Ala Trp Gln Gln Pro Gln 
        355                 360                 365             


Gln Pro Gln Gln Pro Gln Gln Pro Gln Pro Pro Gln Gln Gln Pro Pro 
    370                 375                 380                 


Gln Pro Gln Gln Pro Gln Pro Gln Gln Pro Gln Gln Pro Gln Gln Pro 
385                 390                 395                 400 


Pro Gln Gln Gln Ser His Leu Val Pro Val Ser Leu Ser Asn Leu Ile 
                405                 410                 415     


Pro Gly Ser Pro Leu Pro His Val Gly Ala Ala Leu Thr Val Thr Thr 
            420                 425                 430         


His Pro His Ile Ser Ile Lys Ser Glu Pro Val Ser Pro Ser Arg Glu 
        435                 440                 445             


Arg Ser Pro Ala Pro Pro Pro Pro Ala Val Phe Pro Ala Ala Arg Pro 
    450                 455                 460                 


Glu Pro Gly Asp Gly Leu Ser Ser Pro Ala Gly Gly Ser Tyr Glu Thr 
465                 470                 475                 480 


Gly Asp Arg Asp Asp Gly Arg Gly Asp Phe Gly Pro Thr Leu Gly Leu 
                485                 490                 495     


Leu Arg Pro Ala Pro Glu Pro Glu Ala Glu Gly Ser Ala Val Lys Arg 
            500                 505                 510         


Met Arg Leu Asp Thr Trp Thr Leu Lys 
        515                 520     


<210>  157
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Glu Ser Arg Glu Thr Leu Ser Ser Ser Arg Gln Arg Gly Gly Glu 
1               5                   10                  15      


Ser Asp Phe Leu Pro Val Ser Ser Ala Lys Pro Pro Ala Ala Pro Gly 
            20                  25                  30          


Cys Ala Gly Glu Pro Leu Leu Ser Thr Pro Gly Pro Gly Lys Gly Ile 
        35                  40                  45              


Pro Val Gly Gly Glu Arg Met Glu Pro Glu Glu Glu Asp Glu Leu Gly 
    50                  55                  60                  


Ser Gly Arg Asp Val Asp Ser Asn Ser Asn Ala Asp Ser Glu Lys Trp 
65                  70                  75                  80  


Val Ala Gly Asp Gly Leu Glu Glu Gln Glu Phe Ser Ile Lys Glu Ala 
                85                  90                  95      


Asn Phe Thr Glu Gly Ser Leu Lys Leu Lys Ile Gln Thr Thr Lys Arg 
            100                 105                 110         


Ala Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Ile Cys Pro Pro Glu 
        115                 120                 125             


Ile Lys Ile Thr Ile Lys Gln Ser Gly Asp Gln Lys Val Ser Arg Ala 
    130                 135                 140                 


Gly Lys Asn Ser Lys Ala Thr Lys Glu Glu Glu Arg Ser His Ser Lys 
145                 150                 155                 160 


Lys Lys Leu Leu Thr Ala Ser Asp Leu Ala Ala Ser Asp Leu Lys Gly 
                165                 170                 175     


Phe Gln Pro Gln Ile Lys Asp Ser Ser Lys Glu Glu Val Trp Lys Arg 
            180                 185                 190         


Arg Gly Gly Gln Gly Ile Pro Phe Lys Lys Gln Phe Leu Ser Gln Glu 
        195                 200                 205             


Arg Ala Met Cys Phe Ser Cys Pro Arg Asn Pro Phe Pro Ala Lys Pro 
    210                 215                 220                 


Gly Ser Leu Thr Leu Pro Phe His Ser Glu Pro Ala Val Trp Ala Gln 
225                 230                 235                 240 


Glu Val 
        


<210>  158
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Ser Asp Ser Thr Trp Met Ser Ala Asp Pro His Leu Ala Ser Ser 
1               5                   10                  15      


Leu Ser Pro Ser Gln Asp Glu Arg Met Arg Ser Pro Gln Asn Leu His 
            20                  25                  30          


Ser Gln Glu Asp Asp Asp Ser Ser Ser Glu Ser Gly Ser Gly Asn Gly 
        35                  40                  45              


Ser Ser Thr Leu Asn Pro Ser Thr Ser Ser Ser Thr Gln Gly Asp Pro 
    50                  55                  60                  


Ala Phe Pro Glu Met Asn Gly Asn Gly Ala Val Ala Pro Met Asp Phe 
65                  70                  75                  80  


Thr Thr Ala Ala Glu Asp Gln Pro Ile Asn Leu Cys Asp Lys Leu Pro 
                85                  90                  95      


Pro Ala Thr Ala Leu Gly Thr Ala Ser Tyr Pro Ser Asp Gly Cys Gly 
            100                 105                 110         


Ala Asp Gly Leu Arg Ser Arg Val Lys Tyr Gly Val Lys Thr Thr Pro 
        115                 120                 125             


Glu Ser Pro Pro Tyr Ser Ser Gly Ser Tyr Asp Ser Ile Lys Thr Glu 
    130                 135                 140                 


Val Ser Gly Cys Pro Glu Asp Leu Thr Val Gly Arg Ala Pro Thr Ala 
145                 150                 155                 160 


Asp Asp Asp Asp Asp Asp His Asp Asp His Glu Asp Asn Asp Lys Met 
                165                 170                 175     


Asn Asp Ser Glu Gly Met Asp Pro Glu Arg Leu Lys Ala Phe Asn Met 
            180                 185                 190         


Phe Val Arg Leu Phe Val Asp Glu Asn Leu Asp Arg Met Val Pro Ile 
        195                 200                 205             


Ser Lys Gln Pro Lys Glu Lys Ile Gln Ala Ile Ile Glu Ser Cys Ser 
    210                 215                 220                 


Arg Gln Phe Pro Glu Phe Gln Glu Arg Ala Arg Lys Arg Ile Arg Thr 
225                 230                 235                 240 


Tyr Leu Lys Ser Cys Arg Arg Met Lys Lys Asn Gly Met Glu Met Thr 
                245                 250                 255     


Arg Pro Thr Pro Pro His Leu Thr Ser Ala Met Ala Glu Asn Ile Leu 
            260                 265                 270         


Ala Ala Ala Cys Glu Ser Glu Thr Arg Lys Ala Ala Lys Arg Met Arg 
        275                 280                 285             


Leu Glu Ile Tyr Gln Ser Ser Gln Asp Glu Pro Ile Ala Leu Asp Lys 
    290                 295                 300                 


Gln His Ser Arg Asp Ser Ala Ala Ile Thr His Ser Thr Tyr Ser Leu 
305                 310                 315                 320 


Pro Ala Ser Ser Tyr Ser Gln Asp Pro Val Tyr Ala Asn Gly Gly Leu 
                325                 330                 335     


Asn Tyr Ser Tyr Arg Gly Tyr Gly Ala Leu Ser Ser Asn Leu Gln Pro 
            340                 345                 350         


Pro Ala Ser Leu Gln Thr Gly Asn His Ser Asn Gly Pro Thr Asp Leu 
        355                 360                 365             


Ser Met Lys Gly Gly Ala Ser Thr Thr Ser Thr Thr Pro Ser Ala Leu 
    370                 375                 380                 


Ser Gly Glu Pro Pro Thr Arg Arg Trp Gly Cys Ser Ser Val 
385                 390                 395             


<210>  159
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Thr Pro Asn Ser Met Thr Glu Asn Gly Leu Thr Ala Trp Asp Lys 
1               5                   10                  15      


Pro Lys His Cys Pro Asp Arg Glu His Asp Trp Lys Leu Val Gly Met 
            20                  25                  30          


Ser Glu Ala Cys Leu His Arg Lys Ser His Ser Glu Arg Arg Ser Thr 
        35                  40                  45              


Leu Lys Asn Glu Gln Ser Ser Pro His Leu Ile Gln Thr Thr Trp Thr 
    50                  55                  60                  


Ser Ser Ile Phe His Leu Asp His Asp Asp Val Asn Asp Gln Ser Val 
65                  70                  75                  80  


Ser Ser Ala Gln Thr Phe Gln Thr Glu Glu Lys Lys Cys Lys Gly Tyr 
                85                  90                  95      


Ile Pro Ser Tyr Leu Asp Lys Asp Glu Leu Cys Val Val Cys Gly Asp 
            100                 105                 110         


Lys Ala Thr Gly Tyr His Tyr Arg Cys Ile Thr Cys Glu Gly Cys Lys 
        115                 120                 125             


Gly Phe Phe Arg Arg Thr Ile Gln Lys Asn Leu His Pro Ser Tyr Ser 
    130                 135                 140                 


Cys Lys Tyr Glu Gly Lys Cys Val Ile Asp Lys Val Thr Arg Asn Gln 
145                 150                 155                 160 


Cys Gln Glu Cys Arg Phe Lys Lys Cys Ile Tyr Val Gly Met Ala Thr 
                165                 170                 175     


Asp Leu Val Leu Asp Asp Ser Lys Arg Leu Ala Lys Arg Lys Leu Ile 
            180                 185                 190         


Glu Glu Asn Arg Glu Lys Arg Arg Arg Glu Glu Leu Gln Lys Ser Ile 
        195                 200                 205             


Gly His Lys Pro Glu Pro Thr Asp Glu Glu Trp Glu Leu Ile Lys Thr 
    210                 215                 220                 


Val Thr Glu Ala His Val Ala Thr Asn Ala Gln Gly Ser His Trp Lys 
225                 230                 235                 240 


Gln Lys Arg Lys Phe Leu Pro Glu Asp Ile Gly Gln Ala Pro Ile Val 
                245                 250                 255     


Asn Ala Pro Glu Gly Gly Lys Val Asp Leu Glu Ala Phe Ser His Phe 
            260                 265                 270         


Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg Val Val Asp Phe Ala Lys 
        275                 280                 285             


Lys Leu Pro Met Phe Cys Glu Leu Pro Cys Glu Asp Gln Ile Ile Leu 
    290                 295                 300                 


Leu Lys Gly Cys Cys Met Glu Ile Met Ser Leu Arg Ala Ala Val Arg 
305                 310                 315                 320 


Tyr Asp Pro Glu Ser Glu Thr Leu Thr Leu Asn Gly Glu Met Ala Val 
                325                 330                 335     


Thr Arg Gly Gln Leu Lys Asn Gly Gly Leu Gly Val Val Ser Asp Ala 
            340                 345                 350         


Ile Phe Asp Leu Gly Met Ser Leu Ser Ser Phe Asn Leu Asp Asp Thr 
        355                 360                 365             


Glu Val Ala Leu Leu Gln Ala Val Leu Leu Met Ser Ser Asp Arg Pro 
    370                 375                 380                 


Gly Leu Ala Cys Val Glu Arg Ile Glu Lys Tyr Gln Asp Ser Phe Leu 
385                 390                 395                 400 


Leu Ala Phe Glu His Tyr Ile Asn Tyr Arg Lys His His Val Thr His 
                405                 410                 415     


Phe Trp Pro Lys Leu Leu Met Lys Val Thr Asp Leu Arg Met Ile Gly 
            420                 425                 430         


Ala Cys His Ala Ser Arg Phe Leu His Met Lys Val Glu Cys Pro Thr 
        435                 440                 445             


Glu Leu Phe Pro Pro Leu Phe Leu Glu Val Phe Glu Asp 
    450                 455                 460     


<210>  160
<211>  1225
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  161
<211>  881
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Lys Lys Gln Phe Asn Arg Met Lys Gln Leu Ala Asn Gln Thr Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Thr Glu Val Leu Ser Glu Asp Leu Leu Gln Ile 
            20                  25                  30          


Glu Arg Arg Leu Asp Thr Val Arg Ser Ile Cys His His Ser His Lys 
        35                  40                  45              


Arg Leu Val Ala Cys Phe Gln Gly Gln His Gly Thr Asp Ala Glu Arg 
    50                  55                  60                  


Arg His Lys Lys Leu Pro Leu Thr Ala Leu Ala Gln Asn Met Gln Glu 
65                  70                  75                  80  


Ala Ser Thr Gln Leu Glu Asp Ser Leu Leu Gly Lys Met Leu Glu Thr 
                85                  90                  95      


Cys Gly Asp Ala Glu Asn Gln Leu Ala Leu Glu Leu Ser Gln His Glu 
            100                 105                 110         


Val Phe Val Glu Lys Glu Ile Val Asp Pro Leu Tyr Gly Ile Ala Glu 
        115                 120                 125             


Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys Gln Leu Ala Arg Leu 
    130                 135                 140                 


Val Leu Asp Trp Asp Ser Val Arg Ala Arg Trp Asn Gln Ala His Lys 
145                 150                 155                 160 


Ser Ser Gly Thr Asn Phe Gln Gly Leu Pro Ser Lys Ile Asp Thr Leu 
                165                 170                 175     


Lys Glu Glu Met Asp Glu Ala Gly Asn Lys Val Glu Gln Cys Lys Asp 
            180                 185                 190         


Gln Leu Ala Ala Asp Met Tyr Asn Phe Met Ala Lys Glu Gly Glu Tyr 
        195                 200                 205             


Gly Lys Phe Phe Val Thr Leu Leu Glu Ala Gln Ala Asp Tyr His Arg 
    210                 215                 220                 


Lys Ala Leu Ala Val Leu Glu Lys Thr Leu Pro Glu Met Arg Ala His 
225                 230                 235                 240 


Gln Asp Lys Trp Ala Glu Lys Pro Ala Phe Gly Thr Pro Leu Glu Glu 
                245                 250                 255     


His Leu Lys Arg Ser Gly Arg Glu Ile Ala Leu Pro Ile Glu Ala Cys 
            260                 265                 270         


Val Met Leu Leu Leu Glu Thr Gly Met Lys Glu Glu Gly Leu Phe Arg 
        275                 280                 285             


Ile Gly Ala Gly Ala Ser Lys Leu Lys Lys Leu Lys Ala Ala Leu Asp 
    290                 295                 300                 


Cys Ser Thr Ser His Leu Asp Glu Phe Tyr Ser Asp Pro His Ala Val 
305                 310                 315                 320 


Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu Pro Leu Met 
                325                 330                 335     


Thr Phe Asn Leu Tyr Glu Glu Trp Thr Gln Val Ala Ser Val Gln Asp 
            340                 345                 350         


Gln Asp Lys Lys Leu Gln Asp Leu Trp Arg Thr Cys Gln Lys Leu Pro 
        355                 360                 365             


Pro Gln Asn Phe Val Asn Phe Arg Tyr Leu Ile Lys Phe Leu Ala Lys 
    370                 375                 380                 


Leu Ala Gln Thr Ser Asp Val Asn Lys Met Thr Pro Ser Asn Ile Ala 
385                 390                 395                 400 


Ile Val Leu Gly Pro Asn Leu Leu Trp Ala Arg Asn Glu Gly Thr Leu 
                405                 410                 415     


Ala Glu Met Ala Ala Ala Thr Ser Val His Val Val Ala Val Ile Glu 
            420                 425                 430         


Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Glu Glu Val Glu Phe 
        435                 440                 445             


Asn Val Ser Glu Ala Phe Val Pro Leu Thr Thr Pro Ser Ser Asn His 
    450                 455                 460                 


Ser Phe His Thr Gly Asn Asp Ser Asp Ser Gly Thr Leu Glu Arg Lys 
465                 470                 475                 480 


Arg Pro Ala Ser Met Ala Val Met Glu Gly Asp Leu Val Lys Lys Glu 
                485                 490                 495     


Ser Phe Gly Val Lys Leu Met Asp Phe Gln Ala His Arg Arg Gly Gly 
            500                 505                 510         


Thr Leu Asn Arg Lys His Ile Ser Pro Ala Phe Gln Pro Pro Leu Pro 
        515                 520                 525             


Pro Thr Asp Gly Ser Thr Val Val Pro Ala Gly Pro Glu Pro Pro Pro 
    530                 535                 540                 


Gln Ser Ser Arg Ala Glu Ser Ser Ser Gly Gly Gly Thr Val Pro Ser 
545                 550                 555                 560 


Ser Ala Gly Ile Leu Glu Gln Gly Pro Ser Pro Gly Asp Gly Ser Pro 
                565                 570                 575     


Pro Lys Pro Lys Asp Pro Val Ser Ala Ala Val Pro Ala Pro Gly Arg 
            580                 585                 590         


Asn Asn Ser Gln Ile Ala Ser Gly Gln Asn Gln Pro Gln Ala Ala Ala 
        595                 600                 605             


Gly Ser His Gln Leu Ser Met Gly Gln Pro His Asn Ala Ala Gly Pro 
    610                 615                 620                 


Ser Pro His Thr Leu Arg Arg Ala Val Lys Lys Pro Ala Pro Ala Pro 
625                 630                 635                 640 


Pro Lys Pro Gly Asn Pro Pro Pro Gly His Pro Gly Gly Gln Ser Ser 
                645                 650                 655     


Ser Gly Thr Ser Gln His Pro Pro Ser Leu Ser Pro Lys Pro Pro Thr 
            660                 665                 670         


Arg Ser Pro Ser Pro Pro Thr Gln His Thr Gly Gln Pro Pro Gly Gln 
        675                 680                 685             


Pro Ser Ala Pro Ser Gln Leu Ser Ala Pro Arg Arg Tyr Ser Ser Ser 
    690                 695                 700                 


Leu Ser Pro Ile Gln Ala Pro Asn His Pro Pro Pro Gln Pro Pro Thr 
705                 710                 715                 720 


Gln Ala Thr Pro Leu Met His Thr Lys Pro Asn Ser Gln Gly Pro Pro 
                725                 730                 735     


Asn Pro Met Ala Leu Pro Ser Glu His Gly Leu Glu Gln Pro Ser His 
            740                 745                 750         


Thr Pro Pro Gln Thr Pro Thr Pro Pro Ser Thr Pro Pro Leu Gly Lys 
        755                 760                 765             


Gln Asn Pro Ser Leu Pro Ala Pro Gln Thr Leu Ala Gly Gly Asn Pro 
    770                 775                 780                 


Glu Thr Ala Gln Pro His Ala Gly Thr Leu Pro Arg Pro Arg Pro Val 
785                 790                 795                 800 


Pro Lys Pro Arg Asn Arg Pro Ser Val Pro Pro Pro Pro Gln Pro Pro 
                805                 810                 815     


Gly Val His Ser Ala Gly Asp Ser Ser Leu Thr Asn Thr Ala Pro Thr 
            820                 825                 830         


Ala Ser Lys Ile Val Thr Asp Ser Asn Ser Arg Val Ser Glu Pro His 
        835                 840                 845             


Arg Ser Ile Phe Pro Glu Met His Ser Asp Ser Ala Ser Lys Asp Val 
    850                 855                 860                 


Pro Gly Arg Ile Leu Leu Asp Ile Asp Asn Asp Thr Glu Ser Thr Ala 
865                 870                 875                 880 


Leu 
    


<210>  162
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Lys Glu Ala Ala Leu Ile Cys Leu Ala Pro Ser Val Pro Pro Ile 
1               5                   10                  15      


Leu Thr Val Lys Ser Trp Asp Thr Met Gln Leu Arg Ala Ala Arg Ser 
            20                  25                  30          


Arg Cys Thr Asn Leu Leu Ala Ala Ser Tyr Ile Glu Asn Gln Gln His 
        35                  40                  45              


Leu Gln His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg 
    50                  55                  60                  


Asn Leu Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala 
65                  70                  75                  80  


Phe His Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala 
                85                  90                  95      


Leu Glu Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu 
            100                 105                 110         


Leu Val Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp 
        115                 120                 125             


Leu Gln Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys 
    130                 135                 140                 


Leu Gln Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser 
145                 150                 155                 160 


Cys Gly Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp 
                165                 170                 175     


Val Gly Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu 
            180                 185                 190         


Glu Gln Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val 
        195                 200                 205             


Met Lys Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val 
    210                 215                 220                 


Thr Ser Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp 
225                 230                 235                 240 


Val Gly Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala 
                245                 250                 255     


Ser Val Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro 
            260                 265                 270         


Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn 
        275                 280                 285             


Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu 
    290                 295                 300                 


Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln 
305                 310                 315                 320 


Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro 
                325                 330                 335     


Phe Gly Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro 
            340                 345                 350         


Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser 
        355                 360                 365             


Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val 
    370                 375                 380                 


Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu 
385                 390                 395                 400 


Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg 
                405                 410                 415     


Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe 
            420                 425                 430         


Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser 
        435                 440                 445             


Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala 
    450                 455                 460                 


Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu 
465                 470                 475                 480 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu 
                485                 490                 495     


Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu 
            500                 505                 510         


Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu 
        515                 520                 525             


Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr 
    530                 535                 540                 


Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp 
545                 550                 555                 560 


Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala 
                565                 570                 575     


Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu 
            580                 585                 590         


Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu 
        595                 600                 605             


His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln 
    610                 615                 620                 


Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr 
625                 630                 635                 640 


Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg 
                645                 650                 655     


Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser 
            660                 665                 670         


Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly 
        675                 680                 685             


Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile 
    690                 695                 700                 


Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val 
705                 710                 715                 720 


Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His 
                725                 730                 735     


Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro 
            740                 745                 750         


Pro Val Tyr Leu Asp Val Leu Gly 
        755                 760 


<210>  163
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Glu Phe Leu Leu Gly Asn Pro Phe Ser Thr Pro Val Gly Gln Cys 
1               5                   10                  15      


Leu Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Thr Leu 
            20                  25                  30          


Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys 
        35                  40                  45              


Asp Ala Ile Arg Ala Leu Lys Lys Arg Leu Asn Gly Asn Arg Asn Tyr 
    50                  55                  60                  


Arg Glu Val Met Leu Ala Leu Thr Ala Trp Ala Asp Ala Phe Arg Ser 
65                  70                  75                  80  


Ser Pro Asp Leu Thr Gly Val Val His Ile Tyr Glu Glu Leu Lys Arg 
                85                  90                  95      


Lys Gly Val Glu Phe Pro Met Ala Asp Leu Asp Ala Leu Ser Pro Ile 
            100                 105                 110         


His Thr Pro Gln Arg Ser Val Pro Glu Val Asp Pro Ala Ala Thr Met 
        115                 120                 125             


Pro Arg Ser Gln Ser Gln Gln Arg Thr Ser Ala Gly Ser Tyr Ser Ser 
    130                 135                 140                 


Pro Pro Pro Ala Pro Tyr Ser Ala Pro Gln Ala Pro Ala Leu Ser Val 
145                 150                 155                 160 


Thr Gly Pro Ile Thr Ala Asn Ser Glu Gln Ile Ala Arg Leu Arg Ser 
                165                 170                 175     


Glu Leu Asp Val Val Arg Gly Asn Thr Lys Val Met Ser Glu Met Leu 
            180                 185                 190         


Thr Glu Met Val Pro Gly Gln Glu Asp Ser Ser Asp Leu Glu Leu Leu 
        195                 200                 205             


Gln Glu Leu Asn Arg Thr Cys Arg Ala Met Gln Gln Arg Ile Val Glu 
    210                 215                 220                 


Leu Ile Ser Arg Val Ser Asn Glu Glu Val Thr Glu Glu Leu Leu His 
225                 230                 235                 240 


Val Asn Asp Asp Leu Asn Asn Val Phe Leu Arg Tyr Glu Arg Phe Glu 
                245                 250                 255     


Arg Tyr Arg Ser Gly Arg Ser Val Gln Asn Ala Ser Asn Gly Val Leu 
            260                 265                 270         


Asn Glu Val Thr Glu Asp Asn Leu Ile Asp Leu Gly Pro Gly Ser Pro 
        275                 280                 285             


Ala Val Val Ser Pro Met Val Gly Asn Thr Ala Pro Pro Ser Ser Leu 
    290                 295                 300                 


Ser Ser Gln Leu Ala Gly Leu Asp Leu Gly Thr Glu Ser Val Ser Gly 
305                 310                 315                 320 


Thr Leu Ser Ser Leu Gln Gln Cys Asn Pro Arg Asp Gly Phe Asp Met 
                325                 330                 335     


Phe Ala Gln Thr Arg Gly Asn Ser Leu Ala Glu Gln Arg Lys Thr Val 
            340                 345                 350         


Thr Tyr Glu Asp Pro Gln Ala Val Gly Gly Leu Ala Ser Ala Leu Asp 
        355                 360                 365             


Asn Arg Lys Gln Ser Ser Glu Gly Ile Pro Val Ala Gln Pro Ser Val 
    370                 375                 380                 


Met Asp Asp Ile Glu Val Trp Leu Arg Thr Asp Leu Lys Gly Asp Asp 
385                 390                 395                 400 


Leu Glu Glu Gly Val Thr Ser Glu Glu Phe Asp Lys Phe Leu Glu Glu 
                405                 410                 415     


Arg Ala Lys Ala Ala Glu Met Val Pro Asp Leu Pro Ser Pro Pro Met 
            420                 425                 430         


Glu Ala Pro Ala Pro Ala Ser Asn Pro Ser Gly Arg Lys Lys Pro Glu 
        435                 440                 445             


Arg Ser Glu Asp Ala Leu Phe Ala Leu 
    450                 455         


<210>  164
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  165
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  166
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met 
    290                 295         


<210>  167
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
    210                 215                 220                 


Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


<210>  168
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Ser Asn Ile Cys Gln Arg Leu Trp Glu Tyr Leu Glu Pro Tyr Leu 
1               5                   10                  15      


Pro Cys Leu Ser Thr Glu Ala Asp Lys Ser Thr Val Ile Glu Asn Pro 
            20                  25                  30          


Gly Ala Leu Cys Ser Pro Gln Ser Gln Arg His Gly His Tyr Phe Val 
        35                  40                  45              


Ala Leu Phe Asp Tyr Gln Ala Arg Thr Ala Glu Asp Leu Ser Phe Arg 
    50                  55                  60                  


Ala Gly Asp Lys Leu Gln Val Leu Asp Thr Leu His Glu Gly Trp Trp 
65                  70                  75                  80  


Phe Ala Arg His Leu Glu Lys Arg Arg Asp Gly Ser Ser Gln Gln Leu 
                85                  90                  95      


Gln Gly Tyr Ile Pro Ser Asn Tyr Val Ala Glu Asp Arg Ser Leu Gln 
            100                 105                 110         


Ala Glu Pro Trp Phe Phe Gly Ala Ile Gly Arg Ser Asp Ala Glu Lys 
        115                 120                 125             


Gln Leu Leu Tyr Ser Glu Asn Lys Thr Gly Ser Phe Leu Ile Arg Glu 
    130                 135                 140                 


Ser Glu Ser Gln Lys Gly Glu Phe Ser Leu Ser Val Leu Asp Gly Ala 
145                 150                 155                 160 


Val Val Lys His Tyr Arg Ile Lys Arg Leu Asp Glu Gly Gly Phe Phe 
                165                 170                 175     


Leu Thr Arg Arg Arg Ile Phe Ser Thr Leu Asn Glu Phe Val Ser His 
            180                 185                 190         


Tyr Thr Lys Thr Ser Asp Gly Leu Cys Val Lys Leu Gly Lys Pro Cys 
        195                 200                 205             


Leu Lys Ile Gln Val Pro Ala Pro Phe Asp Leu Ser Tyr Lys Thr Val 
    210                 215                 220                 


Asp Gln Trp Glu Ile Asp Arg Asn Ser Ile Gln Leu Leu Lys Arg Leu 
225                 230                 235                 240 


Gly Ser Gly Gln Phe Gly Glu Val Trp Glu Gly Leu Trp Asn Asn Thr 
                245                 250                 255     


Thr Pro Val Ala Val Lys Thr Leu Lys Pro Gly Ser Met Asp Pro Asn 
            260                 265                 270         


Asp Phe Leu Arg Glu Ala Gln Ile Met Lys Asn Leu Arg His Pro Lys 
        275                 280                 285             


Leu Ile Gln Leu Tyr Ala Val Cys Thr Leu Glu Asp Pro Ile Tyr Ile 
    290                 295                 300                 


Ile Thr Glu Leu Met Arg His Gly Ser Leu Gln Glu Tyr Leu Gln Asn 
305                 310                 315                 320 


Asp Thr Gly Ser Lys Ile His Leu Thr Gln Gln Val Asp Met Ala Ala 
                325                 330                 335     


Gln Val Ala Ser Gly Met Ala Tyr Leu Glu Ser Arg Asn Tyr Ile His 
            340                 345                 350         


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu His Asn Ile Tyr 
        355                 360                 365             


Lys Val Ala Asp Phe Gly Leu Ala Arg Val Phe Lys Val Asp Asn Glu 
    370                 375                 380                 


Asp Ile Tyr Glu Ser Arg His Glu Ile Lys Leu Pro Val Lys Trp Thr 
385                 390                 395                 400 


Ala Pro Glu Ala Ile Arg Ser Asn Lys Phe Ser Ile Lys Ser Asp Val 
                405                 410                 415     


Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Ile Thr Tyr Gly Lys Met 
            420                 425                 430         


Pro Tyr Ser Gly Met Thr Gly Ala Gln Val Ile Gln Met Leu Ala Gln 
        435                 440                 445             


Asn Tyr Arg Leu Pro Gln Pro Ser Asn Cys Pro Gln Gln Phe Tyr Asn 
    450                 455                 460                 


Ile Met Leu Glu Cys Trp Asn Ala Glu Pro Lys Glu Arg Pro Thr Phe 
465                 470                 475                 480 


Glu Thr Leu Arg Trp Lys Leu Glu Asp Tyr Phe Glu Thr Asp Ser Ser 
                485                 490                 495     


Tyr Ser Asp Ala Asn Asn Phe Ile Arg 
            500                 505 


<210>  169
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Gln Gly His Phe Pro Ala Glu Arg Arg Glu Gly Arg Pro Arg Arg 
1               5                   10                  15      


Gly Thr Arg Gly Gln Gln Gln Leu Leu Val Ser Pro Arg Phe Leu Arg 
            20                  25                  30          


Ala Trp His Pro Pro Pro Val Ser Ala Arg Met Pro Thr Arg Arg Trp 
        35                  40                  45              


Ala Pro Gly Thr Gln Cys Ile Thr Lys Cys Glu His Thr Arg Pro Lys 
    50                  55                  60                  


Pro Gly Glu Leu Ala Phe Arg Lys Gly Asp Val Val Thr Ile Leu Glu 
65                  70                  75                  80  


Ala Cys Glu Asn Lys Ser Trp Tyr Arg Val Lys His His Thr Ser Gly 
                85                  90                  95      


Gln Glu Gly Leu Leu Ala Ala Gly Ala Leu Arg Glu Arg Glu Ala Leu 
            100                 105                 110         


Ser Ala Asp Pro Lys Leu Ser Leu Met Pro Trp Phe His Gly Lys Ile 
        115                 120                 125             


Ser Gly Gln Glu Ala Val Gln Gln Leu Gln Pro Pro Glu Asp Gly Leu 
    130                 135                 140                 


Phe Leu Val Arg Glu Ser Ala Arg His Pro Gly Asp Tyr Val Leu Cys 
145                 150                 155                 160 


Val Ser Phe Gly Arg Asp Val Ile His Tyr Arg Val Leu His Arg Asp 
                165                 170                 175     


Gly His Leu Thr Ile Asp Glu Ala Val Phe Phe Cys Asn Leu Met Asp 
            180                 185                 190         


Met Val Glu His Tyr Ser Lys Asp Lys Gly Ala Ile Cys Thr Lys Leu 
        195                 200                 205             


Val Arg Pro Lys Arg Lys His Gly Thr Lys Ser Ala Glu Glu Glu Leu 
    210                 215                 220                 


Ala Arg Ala Gly Trp Leu Leu Asn Leu Gln His Leu Thr Leu Gly Ala 
225                 230                 235                 240 


Gln Ile Gly Glu Gly Glu Phe Gly Ala Val Leu Gln Gly Glu Tyr Leu 
                245                 250                 255     


Gly Gln Lys Val Ala Val Lys Asn Ile Lys Cys Asp Val Thr Ala Gln 
            260                 265                 270         


Ala Phe Leu Asp Glu Thr Ala Val Met Thr Lys Met Gln His Glu Asn 
        275                 280                 285             


Leu Val Arg Leu Leu Gly Val Ile Leu His Gln Gly Leu Tyr Ile Val 
    290                 295                 300                 


Met Glu His Val Ser Lys Gly Asn Leu Val Asn Phe Leu Arg Thr Arg 
305                 310                 315                 320 


Gly Arg Ala Leu Val Asn Thr Ala Gln Leu Leu Gln Phe Ser Leu His 
                325                 330                 335     


Val Ala Glu Gly Met Glu Tyr Leu Glu Ser Lys Lys Leu Val His Arg 
            340                 345                 350         


Asp Leu Ala Ala Arg Asn Ile Leu Val Ser Glu Asp Leu Val Ala Lys 
        355                 360                 365             


Val Ser Asp Phe Gly Leu Ala Lys Ala Glu Arg Lys Gly Leu Asp Ser 
    370                 375                 380                 


Ser Arg Leu Pro Val Lys Trp Thr Ala Pro Glu Ala Leu Lys His Gly 
385                 390                 395                 400 


Lys Phe Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp 
                405                 410                 415     


Glu Val Phe Ser Tyr Gly Arg Ala Pro Tyr Pro Lys Met Ser Leu Lys 
            420                 425                 430         


Glu Val Ser Glu Ala Val Glu Lys Gly Tyr Arg Met Glu Pro Pro Glu 
        435                 440                 445             


Gly Cys Pro Gly Pro Val His Val Leu Met Ser Ser Cys Trp Glu Ala 
    450                 455                 460                 


Glu Pro Ala Arg Arg Pro Pro Phe Arg Lys Leu Ala Glu Lys Leu Ala 
465                 470                 475                 480 


Arg Glu Leu Arg Ser Ala Gly Ala Pro Ala Ser Val Ser Gly Gln Asp 
                485                 490                 495     


Ala Asp Gly Ser Thr Ser Pro Arg Ser Gln Glu Pro 
            500                 505             


<210>  170
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Glu Glu Glu Glu Gly Ala Val Ala Lys Glu Trp Gly Thr Thr Pro 
1               5                   10                  15      


Ala Gly Pro Val Trp Thr Ala Val Phe Asp Tyr Glu Ala Ala Gly Asp 
            20                  25                  30          


Glu Glu Leu Thr Leu Arg Arg Gly Asp Arg Val Gln Val Leu Ser Gln 
        35                  40                  45              


Asp Cys Ala Val Ser Gly Asp Glu Gly Trp Trp Thr Gly Gln Leu Pro 
    50                  55                  60                  


Ser Gly Arg Val Gly Val Phe Pro Ser Asn Tyr Val Ala Pro Gly Ala 
65                  70                  75                  80  


Pro Ala Ala Pro Ala Gly Leu Gln Leu Pro Gln Glu Ile Pro Phe His 
                85                  90                  95      


Glu Leu Gln Leu Glu Glu Ile Ile Gly Val Gly Gly Phe Gly Lys Val 
            100                 105                 110         


Tyr Arg Ala Leu Trp Arg Gly Glu Glu Val Ala Val Lys Ala Ala Arg 
        115                 120                 125             


Leu Asp Pro Glu Lys Asp Pro Ala Val Thr Ala Glu Gln Val Cys Gln 
    130                 135                 140                 


Glu Ala Arg Leu Phe Gly Ala Leu Gln His Pro Asn Ile Ile Ala Leu 
145                 150                 155                 160 


Arg Gly Ala Cys Leu Asn Pro Pro His Leu Cys Leu Val Met Glu Tyr 
                165                 170                 175     


Ala Arg Gly Gly Ala Leu Ser Arg Val Leu Ala Gly Arg Arg Val Pro 
            180                 185                 190         


Pro His Val Leu Val Asn Trp Ala Val Gln Val Ala Arg Gly Met Asn 
        195                 200                 205             


Tyr Leu His Asn Asp Ala Pro Val Pro Ile Ile His Arg Asp Leu Lys 
    210                 215                 220                 


Ser Ile Asn Ile Leu Ile Leu Glu Ala Ile Glu Asn His Asn Leu Ala 
225                 230                 235                 240 


Asp Thr Val Leu Lys Ile Thr Asp Phe Gly Leu Ala Arg Glu Trp His 
                245                 250                 255     


Lys Thr Thr Lys Met Ser Ala Ala Gly Thr Tyr Ala Trp Met Ala Pro 
            260                 265                 270         


Glu Val Ile Arg Leu Ser Leu Phe Ser Lys Ser Ser Asp Val Trp Ser 
        275                 280                 285             


Phe Gly Val Leu Leu Trp Glu Leu Leu Thr Gly Glu Val Pro Tyr Arg 
    290                 295                 300                 


Glu Ile Asp Ala Leu Ala Val Ala Tyr Gly Val Ala Met Asn Lys Leu 
305                 310                 315                 320 


Thr Leu Pro Ile Pro Ser Thr Cys Pro Glu Pro Phe Ala Arg Leu Leu 
                325                 330                 335     


Glu Glu Cys Trp Asp Pro Asp Pro His Gly Arg Pro Asp Phe Gly Ser 
            340                 345                 350         


Ile Leu Lys Arg Leu Glu Val Ile Glu Gln Ser Ala Leu Phe Gln Met 
        355                 360                 365             


Pro Leu Glu Ser Phe His Ser Leu Gln Glu Asp Trp Lys Leu Glu Ile 
    370                 375                 380                 


Gln His Met Phe Asp Asp Leu Arg Thr Lys Glu Lys Glu Leu Arg Ser 
385                 390                 395                 400 


Arg Glu Glu Glu Leu Leu Arg Ala Ala Gln Glu Gln Arg Phe Gln Glu 
                405                 410                 415     


Glu Gln Leu Arg Arg Arg Glu Gln Glu Leu Ala Glu Arg Glu Met Asp 
            420                 425                 430         


Ile Val Glu Arg Glu Leu His Leu Leu Met Cys Gln Leu Ser Gln Glu 
        435                 440                 445             


Lys Pro Arg Val Arg Lys Arg Lys Gly Asn Phe Lys Arg Ser Arg Leu 
    450                 455                 460                 


Leu Lys Leu Arg Glu Gly Gly Ser His Ile Ser Leu Pro Ser Gly Phe 
465                 470                 475                 480 


Glu His Lys Ile Thr Val Gln Ala Ser Pro Thr Leu Asp Lys Arg Lys 
                485                 490                 495     


Gly Ser Asp Gly Ala Ser Pro Pro Ala Ser Pro Ser Ile Ile Pro Arg 
            500                 505                 510         


Leu Arg Ala Ile Arg Leu Thr Pro Val Asp Cys Gly Gly Ser Ser Ser 
        515                 520                 525             


Gly Ser Ser Ser Gly Gly Ser Gly Thr Trp Ser Arg Gly Gly Pro Pro 
    530                 535                 540                 


Lys Lys Glu Glu Leu Val Gly Gly Lys Lys Lys Gly Arg Thr Trp Gly 
545                 550                 555                 560 


Pro Ser Ser Thr Leu Gln Lys Glu Arg Val Gly Gly Glu Glu Arg Leu 
                565                 570                 575     


Lys Gly Leu Gly Glu Gly Ser Lys Gln Trp Ser Ser Ser Ala Pro Asn 
            580                 585                 590         


Leu Gly Lys Ser Pro Lys His Thr Pro Ile Ala Pro Gly Phe Ala Ser 
        595                 600                 605             


Leu Asn Glu Met Glu Glu Phe Ala Glu Ala Glu Asp Gly Gly Ser Ser 
    610                 615                 620                 


Val Pro Pro Ser Pro Tyr Ser Thr Pro Ser Tyr Leu Ser Val Pro Leu 
625                 630                 635                 640 


Pro Ala Glu Pro Ser Pro Gly Ala Arg Ala Pro Trp Glu Pro Thr Pro 
                645                 650                 655     


Ser Ala Pro Pro Ala Arg Trp Gly His Gly Ala Arg Arg Arg Cys Asp 
            660                 665                 670         


Leu Ala Leu Leu Gly Cys Ala Thr Leu Leu Gly Ala Val Gly Leu Gly 
        675                 680                 685             


Ala Asp Val Ala Glu Ala Arg Ala Ala Asp Gly Glu Glu Gln Arg Arg 
    690                 695                 700                 


Trp Leu Asp Gly Leu Phe Phe Pro Arg Ala Gly Arg Phe Pro Arg Gly 
705                 710                 715                 720 


Leu Ser Pro Pro Ala Arg Pro His Gly Arg Arg Glu Asp Val Gly Pro 
                725                 730                 735     


Gly Leu Gly Leu Ala Pro Ser Ala Thr Leu Val Ser Leu Ser Ser Val 
            740                 745                 750         


Ser Asp Cys Asn Ser Thr Arg Ser Leu Leu Arg Ser Asp Ser Asp Glu 
        755                 760                 765             


Ala Ala Pro Ala Ala Pro Ser Pro Pro Pro Ser Pro Pro Ala Pro Thr 
    770                 775                 780                 


Pro Thr Pro Ser Pro Ser Thr Asn Pro Leu Val Asp Leu Glu Leu Glu 
785                 790                 795                 800 


Ser Phe Lys Lys Asp Pro Arg Gln Ser Leu Thr Pro Thr His Val Thr 
                805                 810                 815     


Ala Ala Cys Ala Val Ser Arg Gly His Arg Arg Thr Pro Ser Asp Gly 
            820                 825                 830         


Ala Leu Gly Gln Arg Gly Pro Pro Glu Pro Ala Gly His Gly Pro Gly 
        835                 840                 845             


Pro Arg Asp Leu Leu Asp Phe Pro Arg Leu Pro Asp Pro Gln Ala Leu 
    850                 855                 860                 


Phe Pro Ala Arg Arg Arg Pro Pro Glu Phe Pro Gly Arg Pro Thr Thr 
865                 870                 875                 880 


Leu Thr Phe Ala Pro Arg Pro Arg Pro Ala Ala Ser Arg Pro Arg Leu 
                885                 890                 895     


Asp Pro Trp Lys Leu Val Ser Phe Gly Arg Thr Leu Thr Ile Ser Pro 
            900                 905                 910         


Pro Ser Arg Pro Asp Thr Pro Glu Ser Pro Gly Pro Pro Ser Val Gln 
        915                 920                 925             


Pro Thr Leu Leu Asp Met Asp Met Glu Gly Gln Asn Gln Asp Ser Thr 
    930                 935                 940                 


Val Pro Leu Cys Gly Ala His Gly Ser His 
945                 950                 


<210>  171
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Ala Asp Val Phe Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val 
1               5                   10                  15      


Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val 
    130                 135                 140                 


Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn 
    210                 215                 220                 


Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro 
305                 310                 315                 320 


Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu 
                325                 330                 335     


Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys 
            340                 345                 350         


Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys 
        355                 360                 365             


Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr 
    370                 375                 380                 


Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu 
385                 390                 395                 400 


Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val 
                405                 410                 415     


Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val 
            420                 425                 430         


Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser 
        435                 440                 445             


Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu 
    450                 455                 460                 


Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala 
465                 470                 475                 480 


Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg 
                485                 490                 495     


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr 
            500                 505                 510         


Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu 
        515                 520                 525             


Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp 
    530                 535                 540                 


Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser 
545                 550                 555                 560 


Leu Ser Lys Glu Ala Val Ser Ile Cys Lys Gly Leu Met Thr Lys His 
                565                 570                 575     


Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg 
            580                 585                 590         


Glu His Ala Phe Phe Arg Arg Ile Asp Trp Glu Lys Leu Glu Asn Arg 
        595                 600                 605             


Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Cys Gly Lys Gly Ala Glu 
    610                 615                 620                 


Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro 
625                 630                 635                 640 


Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe 
                645                 650                 655     


Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val 
            660                 665                 670         


<210>  172
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Lys His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  173
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ser Phe Leu Ser Arg Gln Gln Pro Pro Pro Pro Arg Arg Ala Gly 
1               5                   10                  15      


Ala Ala Cys Thr Leu Arg Gln Lys Leu Ile Phe Ser Pro Cys Ser Asp 
            20                  25                  30          


Cys Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ser Gly His Ser 
        35                  40                  45              


Thr Gly Glu Asp Ser Ala Phe Gln Glu Pro Asp Ser Pro Leu Pro Pro 
    50                  55                  60                  


Ala Arg Ser Pro Thr Glu Pro Gly Pro Glu Arg Arg Arg Ser Pro Gly 
65                  70                  75                  80  


Pro Ala Pro Gly Ser Pro Gly Glu Leu Glu Glu Asp Leu Leu Leu Pro 
                85                  90                  95      


Gly Ala Cys Pro Gly Ala Asp Glu Ala Gly Gly Gly Ala Glu Gly Asp 
            100                 105                 110         


Ser Trp Glu Glu Glu Gly Phe Gly Ser Ser Ser Pro Val Lys Ser Pro 
        115                 120                 125             


Ala Ala Pro Tyr Phe Leu Gly Ser Ser Phe Ser Pro Val Arg Cys Gly 
    130                 135                 140                 


Gly Pro Gly Asp Ala Ser Pro Arg Gly Cys Gly Ala Arg Arg Ala Gly 
145                 150                 155                 160 


Glu Gly Arg Arg Ser Pro Arg Pro Asp His Pro Gly Thr Pro Pro His 
                165                 170                 175     


Lys Thr Phe Arg Lys Leu Arg Leu Phe Asp Thr Pro His Thr Pro Lys 
            180                 185                 190         


Ser Leu Leu Ser Lys Ala Arg Gly Ile Asp Ser Ser Ser Val Lys Leu 
        195                 200                 205             


Arg Gly Ser Ser Leu Phe Met Asp Thr Glu Lys Ser Gly Lys Arg Glu 
    210                 215                 220                 


Phe Asp Val Arg Gln Thr Pro Gln Val Asn Ile Asn Pro Phe Thr Pro 
225                 230                 235                 240 


Asp Ser Leu Leu Leu His Ser Ser Gly Gln Cys Arg Arg Arg Lys Arg 
                245                 250                 255     


Thr Tyr Trp Asn Asp Ser Cys Gly Glu Asp Met Glu Ala Ser Asp Tyr 
            260                 265                 270         


Glu Leu Glu Asp Glu Thr Arg Pro Ala Lys Arg Ile Thr Ile Thr Glu 
        275                 280                 285             


Ser Asn Met Lys Ser Arg Tyr Thr Thr Glu Phe His Glu Leu Glu Lys 
    290                 295                 300                 


Ile Gly Ser Gly Glu Phe Gly Ser Val Phe Lys Cys Val Lys Arg Leu 
305                 310                 315                 320 


Asp Gly Cys Ile Tyr Ala Ile Lys Arg Ser Lys Lys Pro Leu Ala Gly 
                325                 330                 335     


Ser Val Asp Glu Gln Asn Ala Leu Arg Glu Val Tyr Ala His Ala Val 
            340                 345                 350         


Leu Gly Gln His Ser His Val Val Arg Tyr Phe Ser Ala Trp Ala Glu 
        355                 360                 365             


Asp Asp His Met Leu Ile Gln Asn Glu Tyr Cys Asn Gly Gly Ser Leu 
    370                 375                 380                 


Ala Asp Ala Ile Ser Glu Asn Tyr Arg Ile Met Ser Tyr Phe Lys Glu 
385                 390                 395                 400 


Ala Glu Leu Lys Asp Leu Leu Leu Gln Val Gly Arg Gly Leu Arg Tyr 
                405                 410                 415     


Ile His Ser Met Ser Leu Val His Met Asp Ile Lys Pro Ser Asn Ile 
            420                 425                 430         


Phe Ile Ser Arg Thr Ser Ile Pro Asn Ala Ala Ser Glu Glu Gly Asp 
        435                 440                 445             


Glu Asp Asp Trp Ala Ser Asn Lys Val Met Phe Lys Ile Gly Asp Leu 
    450                 455                 460                 


Gly His Val Thr Arg Ile Ser Ser Pro Gln Val Glu Glu Gly Asp Ser 
465                 470                 475                 480 


Arg Phe Leu Ala Asn Glu Val Leu Gln Glu Asn Tyr Thr His Leu Pro 
                485                 490                 495     


Lys Ala Asp Ile Phe Ala Leu Ala Leu Thr Val Val Cys Ala Ala Gly 
            500                 505                 510         


Ala Glu Pro Leu Pro Arg Asn Gly Asp Gln Trp His Glu Ile Arg Gln 
        515                 520                 525             


Gly Arg Leu Pro Arg Ile Pro Gln Val Leu Ser Gln Glu Phe Thr Glu 
    530                 535                 540                 


Leu Leu Lys Val Met Ile His Pro Asp Pro Glu Arg Arg Pro Ser Ala 
545                 550                 555                 560 


Met Ala Leu Val Lys His Ser Val Leu Leu Ser Ala Ser Arg Lys Ser 
                565                 570                 575     


Ala Glu Gln Leu Arg Ile Glu Leu Asn Ala Glu Lys Phe Lys Asn Ser 
            580                 585                 590         


Leu Leu Gln Lys Glu Leu Lys Lys Ala Gln Met Ala Lys Ala Ala Ala 
        595                 600                 605             


Glu Glu Arg Ala Leu Phe Thr Asp Arg Met Ala Thr Arg Ser Thr Thr 
    610                 615                 620                 


Gln Ser Asn Arg Thr Ser Arg Leu Ile Gly Lys Lys Met Asn Arg Ser 
625                 630                 635                 640 


Val Ser Leu Thr Ile Tyr 
                645     


<210>  174
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Gly Ser Lys Met Asn Leu Ile Glu His Ser His Leu Pro Thr Thr 
1               5                   10                  15      


Asp Glu Phe Ser Phe Ser Glu Asn Leu Phe Gly Val Leu Thr Glu Gln 
            20                  25                  30          


Val Ala Gly Pro Leu Gly Gln Asn Leu Glu Val Glu Pro Tyr Ser Gln 
        35                  40                  45              


Tyr Ser Asn Val Gln Phe Pro Gln Val Gln Pro Gln Ile Ser Ser Ser 
    50                  55                  60                  


Ser Tyr Tyr Ser Asn Leu Gly Phe Tyr Pro Gln Gln Pro Glu Glu Trp 
65                  70                  75                  80  


Tyr Ser Pro Gly Ile Tyr Glu Leu Arg Arg Met Pro Ala Glu Thr Leu 
                85                  90                  95      


Tyr Gln Gly Glu Thr Glu Val Ala Glu Met Pro Val Thr Lys Lys Pro 
            100                 105                 110         


Arg Met Gly Ala Ser Ala Gly Arg Ile Lys Gly Asp Glu Leu Cys Val 
        115                 120                 125             


Val Cys Gly Asp Arg Ala Ser Gly Tyr His Tyr Asn Ala Leu Thr Cys 
    130                 135                 140                 


Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile Thr Lys Asn Ala Val 
145                 150                 155                 160 


Tyr Lys Cys Lys Asn Gly Gly Asn Cys Val Met Asp Met Tyr Met Arg 
                165                 170                 175     


Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Lys Glu Met Gly Met 
            180                 185                 190         


Leu Ala Glu Cys Leu Leu Thr Glu Ile Gln Cys Lys Ser Lys Arg Leu 
        195                 200                 205             


Arg Lys Asn Val Lys Gln His Ala Asp Gln Thr Val Asn Glu Asp Ser 
    210                 215                 220                 


Glu Gly Arg Asp Leu Arg Gln Val Thr Ser Thr Thr Lys Ser Cys Arg 
225                 230                 235                 240 


Glu Lys Thr Glu Leu Thr Pro Asp Gln Gln Thr Leu Leu His Phe Ile 
                245                 250                 255     


Met Asp Ser Tyr Asn Lys Gln Arg Met Pro Gln Glu Ile Thr Asn Lys 
            260                 265                 270         


Ile Leu Lys Glu Glu Phe Ser Ala Glu Glu Asn Phe Leu Ile Leu Thr 
        275                 280                 285             


Glu Met Ala Thr Asn His Val Gln Val Leu Val Glu Phe Thr Lys Lys 
    290                 295                 300                 


Leu Pro Gly Phe Gln Thr Leu Asp His Glu Asp Gln Ile Ala Leu Leu 
305                 310                 315                 320 


Lys Gly Ser Ala Val Glu Ala Met Phe Leu Arg Ser Ala Glu Ile Phe 
                325                 330                 335     


Asn Lys Lys Leu Pro Ser Gly His Ser Asp Leu Leu Glu Glu Arg Ile 
            340                 345                 350         


Arg Asn Ser Gly Ile Ser Asp Glu Tyr Ile Thr Pro Met Phe Ser Phe 
        355                 360                 365             


Tyr Lys Ser Ile Gly Glu Leu Lys Met Thr Gln Glu Glu Tyr Ala Leu 
    370                 375                 380                 


Leu Thr Ala Ile Val Ile Leu Ser Pro Asp Arg Gln Tyr Ile Lys Asp 
385                 390                 395                 400 


Arg Glu Ala Val Glu Lys Leu Gln Glu Pro Leu Leu Asp Val Leu Gln 
                405                 410                 415     


Lys Leu Cys Lys Ile His Gln Pro Glu Asn Pro Gln His Phe Ala Cys 
            420                 425                 430         


Leu Leu Gly Arg Leu Thr Glu Leu Arg Thr Phe Asn His His His Ala 
        435                 440                 445             


Glu Met Leu Met Ser Trp Arg Val Asn Asp His Lys Phe Thr Pro Leu 
    450                 455                 460                 


Leu Cys Glu Ile Trp Asp Val Gln 
465                 470         


<210>  175
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Val Glu Asn Glu Arg Leu Arg Gln Glu Met Arg Arg Cys Glu Ala 
1               5                   10                  15      


Glu Leu Gln Glu Leu Arg Thr Lys Pro Ala Gly Pro Cys Pro Gly Cys 
            20                  25                  30          


Glu His Ser Gln Glu Ser Ala Gln Leu Arg Asp Lys Leu Ser Gln Leu 
        35                  40                  45              


Gln Leu Glu Met Ala Glu Ser Lys Gly Met Leu Ser Glu Leu Asn Leu 
    50                  55                  60                  


Glu Val Gln Gln Lys Thr Asp Arg Leu Ala Glu Val Glu Leu Arg Leu 
65                  70                  75                  80  


Lys Asp Cys Leu Ala Glu Lys Ala Gln Glu Glu Glu Arg Leu Ser Arg 
                85                  90                  95      


Arg Leu Arg Asp Ser His Glu Thr Ile Ala Ser Leu Arg Ala Gln Ser 
            100                 105                 110         


Pro Pro Val Lys Tyr Val Ile Lys Thr Val Glu Val Glu Ser Ser Lys 
        115                 120                 125             


Thr Lys Gln Ala Leu Ser Glu Ser Gln Ala Arg Asn Gln His Leu Gln 
    130                 135                 140                 


Glu Gln Val Ala Met Gln Arg Gln Val Leu Lys Glu Met Glu Gln Gln 
145                 150                 155                 160 


Leu Gln Ser Ser His Gln Leu Thr Ala Arg Leu Arg Ala Gln Ile Ala 
                165                 170                 175     


Met Tyr Glu Ser Glu Leu Glu Arg Ala His Gly Gln Met Leu Glu Glu 
            180                 185                 190         


Met Gln Ser Leu Glu Glu Asp Lys Asn Arg Ala Ile Glu Glu Ala Phe 
        195                 200                 205             


Ala Arg Ala Gln Val Glu Met Lys Ala Val His Glu Asn Leu Ala Gly 
    210                 215                 220                 


Val Arg Thr Asn Leu Leu Thr Leu Gln Pro Ala Leu Arg Thr Leu Thr 
225                 230                 235                 240 


Asn Asp Tyr Asn Gly Leu Lys Arg Gln Val Arg Gly Phe Pro Leu Leu 
                245                 250                 255     


Leu Gln Glu Ala Leu Arg Ser Val Lys Ala Glu Ile Gly Gln Ala Ile 
            260                 265                 270         


Glu Glu Val Asn Ser Asn Asn Gln Glu Leu Leu Arg Lys Tyr Arg Arg 
        275                 280                 285             


Glu Leu Gln Leu Arg Lys Lys Cys His Asn Glu Leu Val Arg Leu Lys 
    290                 295                 300                 


Gly Asn Ile Arg Val Ile Ala Arg Val Arg Pro Val Thr Lys Glu Asp 
305                 310                 315                 320 


Gly Glu Gly Pro Glu Ala Thr Asn Ala Val Thr Phe Asp Ala Asp Asp 
                325                 330                 335     


Asp Ser Ile Ile His Leu Leu His Lys Gly Lys Pro Val Ser Phe Glu 
            340                 345                 350         


Leu Asp Lys Val Phe Ser Pro Gln Ala Ser Gln Gln Asp Val Phe Gln 
        355                 360                 365             


Glu Val Gln Ala Leu Val Thr Ser Cys Ile Asp Gly Phe Asn Val Cys 
    370                 375                 380                 


Ile Phe Ala Tyr Gly Gln Thr Gly Ala Gly Lys Thr Tyr Thr Met Glu 
385                 390                 395                 400 


Gly Thr Ala Glu Asn Pro Gly Ile Asn Gln Arg Ala Leu Gln Leu Leu 
                405                 410                 415     


Phe Ser Glu Val Gln Glu Lys Ala Ser Asp Trp Glu Tyr Thr Ile Thr 
            420                 425                 430         


Val Ser Ala Ala Glu Ile Tyr Asn Glu Val Leu Arg Asp Leu Leu Gly 
        435                 440                 445             


Lys Glu Pro Gln Glu Lys Leu Glu Ile Arg Leu Cys Pro Asp Gly Ser 
    450                 455                 460                 


Gly Gln Leu Tyr Val Pro Gly Leu Thr Glu Phe Gln Val Gln Ser Val 
465                 470                 475                 480 


Asp Asp Ile Asn Lys Val Phe Glu Phe Gly His Thr Asn Arg Thr Thr 
                485                 490                 495     


Glu Phe Thr Asn Leu Asn Glu His Ser Ser Arg Ser His Ala Leu Leu 
            500                 505                 510         


Ile Val Thr Val Arg Gly Val Asp Cys Ser Thr Gly Leu Arg Thr Thr 
        515                 520                 525             


Gly Lys Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Val Gly Lys 
    530                 535                 540                 


Ser Gly Ala Glu Gly Ser Arg Leu Arg Glu Ala Gln His Ile Asn Lys 
545                 550                 555                 560 


Ser Leu Ser Ala Leu Gly Asp Val Ile Ala Ala Leu Arg Ser Arg Gln 
                565                 570                 575     


Gly His Val Pro Phe Arg Asn Ser Lys Leu Thr Tyr Leu Leu Gln Asp 
            580                 585                 590         


Ser Leu Ser Gly Asp Ser Lys Thr Leu Met Val Val Gln Val Ser Pro 
        595                 600                 605             


Val Glu Lys Asn Thr Ser Glu Thr Leu Tyr Ser Leu Lys Phe Ala Glu 
    610                 615                 620                 


Arg Val Arg Ser Val Glu Leu Gly Pro Gly Leu Arg Arg Ala Glu Leu 
625                 630                 635                 640 


Gly Ser Trp Ser Ser Gln Glu His Leu Glu Trp Glu Pro Ala Cys Gln 
                645                 650                 655     


Thr Pro Gln Pro Ser Ala Arg Ala His Ser Ala Pro Ser Ser Gly Thr 
            660                 665                 670         


Ser Ser Arg Pro Gly Ser Ile Arg Arg Lys Leu Gln Pro Ser Gly Lys 
        675                 680                 685             


Ser Arg Pro Leu Pro Val 
    690                 


<210>  176
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Glu Phe Val Met Lys Gln Ala Leu Gly Gly Ala Thr Lys Asp Met 
1               5                   10                  15      


Gly Lys Met Leu Gly Gly Asp Glu Glu Lys Asp Pro Asp Ala Ala Lys 
            20                  25                  30          


Lys Glu Glu Glu Arg Gln Glu Ala Leu Arg Gln Ala Glu Glu Glu Arg 
        35                  40                  45              


Lys Ala Lys Tyr Ala Lys Met Glu Ala Glu Arg Glu Ala Val Arg Gln 
    50                  55                  60                  


Gly Ile Arg Asp Lys Tyr Gly Ile Lys Lys Lys Glu Glu Arg Glu Ala 
65                  70                  75                  80  


Glu Ala Gln Ala Ala Met Glu Ala Asn Ser Glu Gly Ser Leu Thr Arg 
                85                  90                  95      


Pro Lys Lys Ala Ile Pro Pro Gly Cys Gly Asp Glu Val Glu Glu Glu 
            100                 105                 110         


Asp Glu Ser Ile Leu Asp Thr Val Ile Lys Tyr Leu Pro Gly Pro Leu 
        115                 120                 125             


Gln Asp Met Leu Lys Lys 
    130                 


<210>  177
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Ala Ala Thr Ala Ala Ala Val Val Ala Glu Glu Asp Thr Glu Leu 
1               5                   10                  15      


Arg Asp Leu Leu Val Gln Thr Leu Glu Asn Ser Gly Val Leu Asn Arg 
            20                  25                  30          


Ile Lys Ala Glu Leu Arg Ala Ala Val Phe Leu Ala Leu Glu Glu Gln 
        35                  40                  45              


Glu Lys Val Glu Asn Lys Thr Pro Leu Val Asn Glu Ser Leu Lys Lys 
    50                  55                  60                  


Phe Leu Asn Thr Lys Asp Gly Arg Leu Val Ala Ser Leu Val Ala Glu 
65                  70                  75                  80  


Phe Leu Gln Phe Phe Asn Leu Asp Phe Thr Leu Ala Val Phe Gln Pro 
                85                  90                  95      


Glu Thr Ser Thr Leu Gln Gly Leu Glu Gly Arg Glu Asn Leu Ala Arg 
            100                 105                 110         


Asp Leu Gly Ile Ile Glu Ala Glu Gly Thr Val Gly Gly Pro Leu Leu 
        115                 120                 125             


Leu Glu Val Ile Arg Arg Cys Gln Gln Lys Glu Lys Gly Pro Thr Thr 
    130                 135                 140                 


Gly Glu Gly Ala Leu Asp Leu Ser Asp Val His Ser Pro Pro Lys Ser 
145                 150                 155                 160 


Pro Glu Gly Lys Thr Ser Ala Gln Thr Thr Pro Ser Lys Ile Pro Arg 
                165                 170                 175     


Tyr Lys Gly Gln Gly Lys Lys Lys Thr Ser Gly Gln Lys Ala Gly Asp 
            180                 185                 190         


Lys Lys Ala Asn Asp Glu Ala Asn Gln Ser Asp Thr Ser Val Ser Leu 
        195                 200                 205             


Ser Glu Pro Lys Ser Lys Ser Ser Leu His Leu Leu Ser His Glu Thr 
    210                 215                 220                 


Lys Ile Gly Ser Phe Leu Ser Asn Arg Thr Leu Asp Gly Lys Asp Lys 
225                 230                 235                 240 


Ala Gly Leu Cys Pro Asp Glu Asp Asp Met Glu Gly Asp Ser Phe Phe 
                245                 250                 255     


Asp Asp Pro Ile Pro Lys Pro Glu Lys Thr Tyr Gly Leu Arg Lys Glu 
            260                 265                 270         


Pro Arg Lys Gln Ala Gly Ser Leu Ala Ser Leu Ser Asp Ala Pro Pro 
        275                 280                 285             


Leu Lys Ser Gly Leu Ser Ser Leu Ala Gly Ala Pro Ser Leu Lys Asp 
    290                 295                 300                 


Ser Glu Ser Lys Arg Gly Asn Thr Val Leu Lys Asp Leu Lys Leu Ile 
305                 310                 315                 320 


Ser Asp Lys Ile Gly Ser Leu Gly Leu Gly Thr Gly Glu Asp Asp Asp 
                325                 330                 335     


Tyr Val Asp Asp Phe Asn Ser Thr Ser His Arg Ser Glu Lys Ser Glu 
            340                 345                 350         


Ile Ser Ile Gly Glu Glu Ile Glu Glu Asp Leu Ser Val Glu Ile Asp 
        355                 360                 365             


Asp Ile Asn Thr Ser Asp Lys Leu Asp Asp Leu Thr Gln Asp Leu Thr 
    370                 375                 380                 


Val Ser Gln Leu Ser Asp Val Ala Asp Tyr Leu Glu Asp Val Ala 
385                 390                 395                 


<210>  178
<211>  1297
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ala Val Pro Ser Leu Trp Pro Trp Gly Ala Cys Leu Pro Val Ile 
1               5                   10                  15      


Phe Leu Ser Leu Gly Phe Gly Leu Asp Thr Val Glu Val Cys Pro Ser 
            20                  25                  30          


Leu Asp Ile Arg Ser Glu Val Ala Glu Leu Arg Gln Leu Glu Asn Cys 
        35                  40                  45              


Ser Val Val Glu Gly His Leu Gln Ile Leu Leu Met Phe Thr Ala Thr 
    50                  55                  60                  


Gly Glu Asp Phe Arg Gly Leu Ser Phe Pro Arg Leu Thr Gln Val Thr 
65                  70                  75                  80  


Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu Glu Ser Leu Arg Asp 
                85                  90                  95      


Leu Phe Pro Asn Leu Ala Val Ile Arg Gly Thr Arg Leu Phe Leu Gly 
            100                 105                 110         


Tyr Ala Leu Val Ile Phe Glu Met Pro His Leu Arg Asp Val Ala Leu 
        115                 120                 125             


Pro Ala Leu Gly Ala Val Leu Arg Gly Ala Val Arg Val Glu Lys Asn 
    130                 135                 140                 


Gln Glu Leu Cys His Leu Ser Thr Ile Asp Trp Gly Leu Leu Gln Pro 
145                 150                 155                 160 


Ala Pro Gly Ala Asn His Ile Val Gly Asn Lys Leu Gly Glu Glu Cys 
                165                 170                 175     


Ala Asp Val Cys Pro Gly Val Leu Gly Ala Ala Gly Glu Pro Cys Ala 
            180                 185                 190         


Lys Thr Thr Phe Ser Gly His Thr Asp Tyr Arg Cys Trp Thr Ser Ser 
        195                 200                 205             


His Cys Gln Arg Val Cys Pro Cys Pro His Gly Met Ala Cys Thr Ala 
    210                 215                 220                 


Arg Gly Glu Cys Cys His Thr Glu Cys Leu Gly Gly Cys Ser Gln Pro 
225                 230                 235                 240 


Glu Asp Pro Arg Ala Cys Val Ala Cys Arg His Leu Tyr Phe Gln Gly 
                245                 250                 255     


Ala Cys Leu Trp Ala Cys Pro Pro Gly Thr Tyr Gln Tyr Glu Ser Trp 
            260                 265                 270         


Arg Cys Val Thr Ala Glu Arg Cys Ala Ser Leu His Ser Val Pro Gly 
        275                 280                 285             


Arg Ala Ser Thr Phe Gly Ile His Gln Gly Ser Cys Leu Ala Gln Cys 
    290                 295                 300                 


Pro Ser Gly Phe Thr Arg Asn Ser Ser Ser Ile Phe Cys His Lys Cys 
305                 310                 315                 320 


Glu Gly Leu Cys Pro Lys Glu Cys Lys Val Gly Thr Lys Thr Ile Asp 
                325                 330                 335     


Ser Ile Gln Ala Ala Gln Asp Leu Val Gly Cys Thr His Val Glu Gly 
            340                 345                 350         


Ser Leu Ile Leu Asn Leu Arg Gln Gly Tyr Asn Leu Glu Pro Gln Leu 
        355                 360                 365             


Gln His Ser Leu Gly Leu Val Glu Thr Ile Thr Gly Phe Leu Lys Ile 
    370                 375                 380                 


Lys His Ser Phe Ala Leu Val Ser Leu Gly Phe Phe Lys Asn Leu Lys 
385                 390                 395                 400 


Leu Ile Arg Gly Asp Ala Met Val Asp Gly Asn Tyr Thr Leu Tyr Val 
                405                 410                 415     


Leu Asp Asn Gln Asn Leu Gln Gln Leu Gly Ser Trp Val Ala Ala Gly 
            420                 425                 430         


Leu Thr Ile Pro Val Gly Lys Ile Tyr Phe Ala Phe Asn Pro Arg Leu 
        435                 440                 445             


Cys Leu Glu His Ile Tyr Arg Leu Glu Glu Val Thr Gly Thr Arg Gly 
    450                 455                 460                 


Arg Gln Asn Lys Ala Glu Ile Asn Pro Arg Thr Asn Gly Asp Arg Ala 
465                 470                 475                 480 


Ala Cys Gln Thr Arg Thr Leu Arg Phe Val Ser Asn Val Thr Glu Ala 
                485                 490                 495     


Asp Arg Ile Leu Leu Arg Trp Glu Arg Tyr Glu Pro Leu Glu Ala Arg 
            500                 505                 510         


Asp Leu Leu Ser Phe Ile Val Tyr Tyr Lys Glu Ser Pro Phe Gln Asn 
        515                 520                 525             


Ala Thr Glu His Val Gly Pro Asp Ala Cys Gly Thr Gln Ser Trp Asn 
    530                 535                 540                 


Leu Leu Asp Val Glu Leu Pro Leu Ser Arg Thr Gln Glu Pro Gly Val 
545                 550                 555                 560 


Thr Leu Ala Ser Leu Lys Pro Trp Thr Gln Tyr Ala Val Phe Val Arg 
                565                 570                 575     


Ala Ile Thr Leu Thr Thr Glu Glu Asp Ser Pro His Gln Gly Ala Gln 
            580                 585                 590         


Ser Pro Ile Val Tyr Leu Arg Thr Leu Pro Ala Ala Pro Thr Val Pro 
        595                 600                 605             


Gln Asp Val Ile Ser Thr Ser Asn Ser Ser Ser His Leu Leu Val Arg 
    610                 615                 620                 


Trp Lys Pro Pro Thr Gln Arg Asn Gly Asn Leu Thr Tyr Tyr Leu Val 
625                 630                 635                 640 


Leu Trp Gln Arg Leu Ala Glu Asp Gly Asp Leu Tyr Leu Asn Asp Tyr 
                645                 650                 655     


Cys His Arg Gly Leu Arg Leu Pro Thr Ser Asn Asn Asp Pro Arg Phe 
            660                 665                 670         


Asp Gly Glu Asp Gly Asp Pro Glu Ala Glu Met Glu Ser Asp Cys Cys 
        675                 680                 685             


Pro Cys Gln His Pro Pro Pro Gly Gln Val Leu Pro Pro Leu Glu Ala 
    690                 695                 700                 


Gln Glu Ala Ser Phe Gln Lys Lys Phe Glu Asn Phe Leu His Asn Ala 
705                 710                 715                 720 


Ile Thr Ile Pro Ile Ser Pro Trp Lys Val Thr Ser Ile Asn Lys Ser 
                725                 730                 735     


Pro Gln Arg Asp Ser Gly Arg His Arg Arg Ala Ala Gly Pro Leu Arg 
            740                 745                 750         


Leu Gly Gly Asn Ser Ser Asp Phe Glu Ile Gln Glu Asp Lys Val Pro 
        755                 760                 765             


Arg Glu Arg Ala Val Leu Ser Gly Leu Arg His Phe Thr Glu Tyr Arg 
    770                 775                 780                 


Ile Asp Ile His Ala Cys Asn His Ala Ala His Thr Val Gly Cys Ser 
785                 790                 795                 800 


Ala Ala Thr Phe Val Phe Ala Arg Thr Met Pro His Arg Glu Ala Asp 
                805                 810                 815     


Gly Ile Pro Gly Lys Val Ala Trp Glu Ala Ser Ser Lys Asn Ser Val 
            820                 825                 830         


Leu Leu Arg Trp Leu Glu Pro Pro Asp Pro Asn Gly Leu Ile Leu Lys 
        835                 840                 845             


Tyr Glu Ile Lys Tyr Arg Arg Leu Gly Glu Glu Ala Thr Val Leu Cys 
    850                 855                 860                 


Val Ser Arg Leu Arg Tyr Ala Lys Phe Gly Gly Val His Leu Ala Leu 
865                 870                 875                 880 


Leu Pro Pro Gly Asn Tyr Ser Ala Arg Val Arg Ala Thr Ser Leu Ala 
                885                 890                 895     


Gly Asn Gly Ser Trp Thr Asp Ser Val Ala Phe Tyr Ile Leu Gly Pro 
            900                 905                 910         


Glu Glu Glu Asp Ala Gly Gly Leu His Val Leu Leu Thr Ala Thr Pro 
        915                 920                 925             


Val Gly Leu Thr Leu Leu Ile Val Leu Ala Ala Leu Gly Phe Phe Tyr 
    930                 935                 940                 


Gly Lys Lys Arg Asn Arg Thr Leu Tyr Ala Ser Val Asn Pro Glu Tyr 
945                 950                 955                 960 


Phe Ser Ala Ser Asp Met Tyr Val Pro Asp Glu Trp Glu Val Pro Arg 
                965                 970                 975     


Glu Gln Ile Ser Ile Ile Arg Glu Leu Gly Gln Gly Ser Phe Gly Met 
            980                 985                 990         


Val Tyr Glu Gly Leu Ala Arg Gly  Leu Glu Ala Gly Glu  Glu Ser Thr 
        995                 1000                 1005             


Pro Val  Ala Leu Lys Thr Val  Asn Glu Leu Ala Ser  Pro Arg Glu 
    1010                 1015                 1020             


Cys Ile  Glu Phe Leu Lys Glu  Ala Ser Val Met Lys  Ala Phe Lys 
    1025                 1030                 1035             


Cys His  His Val Val Arg Leu  Leu Gly Val Val Ser  Gln Gly Gln 
    1040                 1045                 1050             


Pro Thr  Leu Val Ile Met Glu  Leu Met Thr Arg Gly  Asp Leu Lys 
    1055                 1060                 1065             


Ser His  Leu Arg Ser Leu Arg  Pro Glu Ala Glu Asn  Asn Pro Gly 
    1070                 1075                 1080             


Leu Pro  Gln Pro Ala Leu Gly  Glu Met Ile Gln Met  Ala Gly Glu 
    1085                 1090                 1095             


Ile Ala  Asp Gly Met Ala Tyr  Leu Ala Ala Asn Lys  Phe Val His 
    1100                 1105                 1110             


Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val Ser Gln  Asp Phe Thr 
    1115                 1120                 1125             


Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg Asp Val  Tyr Glu Thr 
    1130                 1135                 1140             


Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu Leu Pro  Val Arg Trp 
    1145                 1150                 1155             


Met Ala  Pro Glu Ser Leu Lys  Asp Gly Ile Phe Thr  Thr His Ser 
    1160                 1165                 1170             


Asp Val  Trp Ser Phe Gly Val  Val Leu Trp Glu Ile  Val Thr Leu 
    1175                 1180                 1185             


Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn Glu Gln  Val Leu Lys 
    1190                 1195                 1200             


Phe Val  Met Asp Gly Gly Val  Leu Glu Glu Leu Glu  Gly Cys Pro 
    1205                 1210                 1215             


Leu Gln  Leu Gln Glu Leu Met  Ser Arg Cys Trp Gln  Pro Asn Pro 
    1220                 1225                 1230             


Arg Leu  Arg Pro Ser Phe Thr  His Ile Leu Asp Ser  Ile Gln Glu 
    1235                 1240                 1245             


Glu Leu  Arg Pro Ser Phe Arg  Leu Leu Ser Phe Tyr  Tyr Ser Pro 
    1250                 1255                 1260             


Glu Cys  Arg Gly Ala Arg Gly  Ser Leu Pro Thr Thr  Asp Ala Glu 
    1265                 1270                 1275             


Pro Asp  Ser Ser Pro Thr Pro  Arg Asp Cys Ser Pro  Gln Asn Gly 
    1280                 1285                 1290             


Gly Pro  Gly His 
    1295         


<210>  179
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Ser His Arg Thr Ser Ser Thr Phe Arg Ala Glu Arg Ser Phe His 
1               5                   10                  15      


Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ser Ser Ser Ala Ser Arg 
            20                  25                  30          


Ala Leu Pro Ala Gln Asp Pro Pro Met Glu Lys Ala Leu Ser Met Phe 
        35                  40                  45              


Ser Asp Asp Phe Gly Ser Phe Met Arg Pro His Ser Glu Pro Leu Ala 
    50                  55                  60                  


Phe Pro Ala Arg Pro Gly Gly Ala Gly Asn Ile Lys Thr Leu Gly Asp 
65                  70                  75                  80  


Ala Tyr Glu Phe Ala Val Asp Val Arg Asp Phe Ser Pro Glu Asp Ile 
                85                  90                  95      


Ile Val Thr Thr Ser Asn Asn His Ile Glu Val Arg Ala Glu Lys Leu 
            100                 105                 110         


Ala Ala Asp Gly Thr Val Met Asn Thr Phe Ala His Lys Cys Gln Leu 
        115                 120                 125             


Pro Glu Asp Val Asp Pro Thr Ser Val Thr Ser Ala Leu Arg Glu Asp 
    130                 135                 140                 


Gly Ser Leu Thr Ile Arg Ala Arg Arg His Pro His Thr Glu His Val 
145                 150                 155                 160 


Gln Gln Thr Phe Arg Thr Glu Ile Lys Ile 
                165                 170 


<210>  180
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Gly Cys Arg His Ser Arg Leu Ser Ser Cys Lys Pro Pro Lys Lys 
1               5                   10                  15      


Lys Arg Gln Glu Pro Glu Pro Glu Gln Pro Pro Arg Pro Glu Pro His 
            20                  25                  30          


Glu Leu Gly Pro Leu Asn Gly Asp Thr Ala Ile Thr Val Gln Leu Cys 
        35                  40                  45              


Ala Ser Glu Glu Ala Glu Arg His Gln Lys Asp Ile Thr Arg Ile Leu 
    50                  55                  60                  


Gln Gln His Glu Glu Glu Lys Lys Lys Trp Ala Gln Gln Val Glu Lys 
65                  70                  75                  80  


Glu Arg Glu Leu Glu Leu Arg Asp Arg Leu Asp Glu Gln Gln Arg Val 
                85                  90                  95      


Leu Glu Gly Lys Asn Glu Glu Ala Leu Gln Val Leu Arg Ala Ser Tyr 
            100                 105                 110         


Glu Gln Glu Lys Glu Ala Leu Thr His Ser Phe Arg Glu Ala Ser Ser 
        115                 120                 125             


Thr Gln Gln Glu Thr Ile Asp Arg Leu Thr Ser Gln Leu Glu Ala Phe 
    130                 135                 140                 


Gln Ala Lys Met Lys Arg Val Glu Glu Ser Ile Leu Ser Arg Asn Tyr 
145                 150                 155                 160 


Lys Lys His Ile Gln Asp Tyr Gly Ser Pro Ser Gln Phe Trp Glu Gln 
                165                 170                 175     


Glu Leu Glu Ser Leu His Phe Val Ile Glu Met Lys Asn Glu Arg Ile 
            180                 185                 190         


His Glu Leu Asp Arg Arg Leu Ile Leu Met Glu Thr Val Lys Glu Lys 
        195                 200                 205             


Asn Leu Ile Leu Glu Glu Lys Ile Thr Thr Leu Gln Gln Glu Asn Glu 
    210                 215                 220                 


Asp Leu His Val Arg Ser Arg Asn Gln Val Val Leu Ser Arg Gln Leu 
225                 230                 235                 240 


Ser Glu Asp Leu Leu Leu Thr Arg Glu Ala Leu Glu Lys Glu Val Gln 
                245                 250                 255     


Leu Arg Arg Gln Leu Gln Gln Glu Lys Glu Glu Leu Leu Tyr Arg Val 
            260                 265                 270         


Leu Gly Ala Asn Ala Ser Pro Ala Phe Pro Leu Ala Pro Val Thr Pro 
        275                 280                 285             


Thr Glu Val Ser Phe Leu Ala Thr 
    290                 295     


<210>  181
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Ser Gln Gly Leu Pro Ala Ala Gly Ser Val Leu Gln Arg Ser Val 
1               5                   10                  15      


Ala Ala Pro Gly Asn Gln Pro Gln Pro Gln Pro Gln Gln Gln Ser Pro 
            20                  25                  30          


Glu Asp Asp Asp Arg Lys Val Arg Arg Arg Glu Lys Asn Arg Val Ala 
        35                  40                  45              


Ala Gln Arg Ser Arg Lys Lys Gln Thr Gln Lys Ala Asp Lys Leu His 
    50                  55                  60                  


Glu Glu Tyr Glu Ser Leu Glu Gln Glu Asn Thr Met Leu Arg Arg Glu 
65                  70                  75                  80  


Ile Gly Lys Leu Thr Glu Glu Leu Lys His Leu Thr Glu Ala Leu Lys 
                85                  90                  95      


Glu His Glu Lys Met Cys Pro Leu Leu Leu Cys Pro Met Asn Phe Val 
            100                 105                 110         


Pro Val Pro Pro Arg Pro Asp Pro Val Ala Gly Cys Leu Pro Arg 
        115                 120                 125         


<210>  182
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Thr Ser Gly Ser Ala Leu Thr Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu 
    50                  55                  60                  


Gln Leu Leu Asn Leu Phe Ala Tyr Gly Thr Tyr Pro Asp Tyr Ile Ala 
65                  70                  75                  80  


Asn Lys Glu Ser Leu Pro Glu Leu Ser Thr Ala Gln Gln Asn Lys Leu 
                85                  90                  95      


Lys His Leu Thr Ile Val Ser Leu Ala Ser Arg Met Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ser Val Leu Leu Lys Asp Leu Glu Met Arg Asn Leu Arg Glu Leu 
        115                 120                 125             


Glu Asp Leu Ile Ile Glu Ala Val Tyr Thr Asp Ile Ile Gln Gly Lys 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Leu Leu Glu Val Asp Phe Cys Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Arg Lys Lys Asp Ile Asn Asn Ile Val Lys Thr Leu His Glu 
                165                 170                 175     


Trp Cys Asp Gly Cys Glu Ala Val Leu Leu Gly Ile Glu Gln Gln Val 
            180                 185                 190         


Leu Arg Ala Asn Gln Tyr Lys Glu Asn His Asn Arg Thr Gln Gln Gln 
        195                 200                 205             


Val Glu Ala Glu Val Thr Asn Ile Lys Lys Thr Leu Lys Ala Thr Ala 
    210                 215                 220                 


Ser Ser Ser Ala Gln Glu Met Glu Gln Gln Leu Ala Glu Arg Glu Cys 
225                 230                 235                 240 


Pro Pro His Ala Glu Gln Arg Gln Pro Thr Lys Lys Met Ser Lys Val 
                245                 250                 255     


Lys Gly Leu Val Ser Ser Arg His 
            260                 


<210>  183
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  183

Gly Asn Leu Phe Gly Arg Lys Lys Gln Ser Arg Val Thr Glu Gln Asp 
1               5                   10                  15      


Lys Ala Ile Leu Gln Leu Lys Gln Gln Arg Asp Lys Leu Arg Gln Tyr 
            20                  25                  30          


Gln Lys Arg Ile Ala Gln Gln Leu Glu Arg Glu Arg Ala Leu Ala Arg 
        35                  40                  45              


Gln Leu Leu Arg Asp Gly Arg Lys Glu Arg Ala Lys Leu Leu Leu Lys 
    50                  55                  60                  


Lys Lys Arg Tyr Gln Glu Gln Leu Leu Asp Arg Thr Glu Asn Gln Ile 
65                  70                  75                  80  


Ser Ser Leu Glu Ala Met Val Gln Ser Ile Glu Phe Thr Gln Ile Glu 
                85                  90                  95      


Met Lys Val Met Glu Gly Leu Gln Leu Gly Asn Glu Cys Leu Asn Lys 
            100                 105                 110         


Met His Gln Val Met Ser Ile Glu Glu Val Glu Arg Ile Leu Asp Glu 
        115                 120                 125             


Thr Gln Glu Ala Val Glu Tyr Gln Arg Gln Ile Asp Glu Leu Leu Ala 
    130                 135                 140                 


Gly Ser Phe Thr Gln Glu Asp Glu Asp Ala Ile Leu Glu Glu Leu Ser 
145                 150                 155                 160 


Ala Ile Thr Gln Glu Gln Ile Glu Leu Pro Glu Val Pro Ser Glu Pro 
                165                 170                 175     


Leu Pro Glu Lys Ile Pro Glu Asn Val Pro Val Lys Ala Arg Pro Arg 
            180                 185                 190         


Gln Ala Glu Leu Val Ala Ala Ser 
        195                 200 


<210>  184
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ser Asp Glu Val Phe Ser Thr Thr Leu Ala Tyr Thr Lys Ser Pro 
1               5                   10                  15      


Lys Val Thr Lys Arg Thr Thr Phe Gln Asp Glu Leu Ile Arg Ala Ile 
            20                  25                  30          


Thr Ala Arg Ser Ala Arg Gln Arg Ser Ser Glu Tyr Ser Asp Asp Phe 
        35                  40                  45              


Asp Ser Asp Glu Ile Val Ser Leu Gly Asp Phe Ser Asp Thr Ser Ala 
    50                  55                  60                  


Asp Glu Asn Ser Val Asn Lys Lys Met Asn Asp Phe His Ile Ser Asp 
65                  70                  75                  80  


Asp Glu Glu Lys Asn Pro Ser Lys Leu Leu Phe Leu Lys Thr Asn Lys 
                85                  90                  95      


Ser Asn Gly Asn Ile Thr Lys Asp Glu Pro Val Cys Ala Ile Lys Asn 
            100                 105                 110         


Glu Glu Glu Met Ala Pro Asp Gly Cys Glu Asp Ile Val Val Lys Ser 
        115                 120                 125             


Phe Ser Glu Ser Gln Asn Lys Asp Glu Glu Phe Glu Lys Asp Lys Ile 
    130                 135                 140                 


Lys Met Lys Pro Lys Pro Arg Ile Leu Ser Ile Lys Ser Thr Ser Ser 
145                 150                 155                 160 


Ala Glu Asn Asn Ser Leu Asp Thr Asp Asp His Phe Lys Pro Ser Pro 
                165                 170                 175     


Trp Pro Arg Ser Met Leu Lys Lys Lys Ser His Met Glu Glu Lys Asp 
            180                 185                 190         


Gly Leu Glu Asp Lys Glu Thr Ala Leu Ser Glu Glu Leu Glu Leu His 
        195                 200                 205             


Ser Ala Pro Ser Ser Leu Pro Thr Pro Asn Gly Ile Gln Leu Glu Ala 
    210                 215                 220                 


Glu Lys Lys Ala Phe Ser Glu Asn Leu Asp Pro Glu Asp Ser Cys Leu 
225                 230                 235                 240 


Thr Ser Leu Ala Ser Ser Ser Leu Lys Gln Ile Leu Gly Asp Ser Phe 
                245                 250                 255     


Ser Pro Gly Ser Glu Gly Asn Ala Ser Gly Lys Asp Pro Asn Glu Glu 
            260                 265                 270         


Ile Thr Glu Asn His Asn Ser Leu Lys Ser Asp Glu Asn Lys Glu Asn 
        275                 280                 285             


Ser Phe Ser Ala Asp His Val Thr Thr Ala Val Glu Lys Ser Lys Glu 
    290                 295                 300                 


Ser Gln Val Thr Ala Asp Asp Leu Glu Glu Glu Lys Ala Lys Ala Glu 
305                 310                 315                 320 


Leu Ile Met Asp Asp Asp Arg Thr Val Asp Pro Leu Leu Ser Lys Ser 
                325                 330                 335     


Gln Ser Ile Leu Ile Ser Thr Ser Ala Thr Ala Ser Ser Lys Lys Thr 
            340                 345                 350         


Ile Glu Asp Arg Asn Ile Lys Asn Lys Lys Ser Thr Asn Asn Arg Ala 
        355                 360                 365             


Ser Ser Ala Ser Ala Arg Ser Gly 
    370                 375     


<210>  185
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Glu Leu Gly Arg Gly Ala Tyr Gly Val Val Glu Lys Met Arg His 
1               5                   10                  15      


Val Pro Ser Gly Gln Ile Met Ala Val Lys Arg Ile Arg Ala Thr Val 
            20                  25                  30          


Asn Ser Gln Glu Gln Lys Arg Leu Leu Met Asp Leu Asp Ile Ser Met 
        35                  40                  45              


Arg Thr Val Asp Cys Pro Phe Thr Val Thr Phe Tyr Gly Ala Leu Phe 
    50                  55                  60                  


Arg Glu Gly Asp Met Trp Ile Cys Met Glu Leu Met Asp Thr Ser Leu 
65                  70                  75                  80  


Asp Lys Phe Tyr Lys Gln Val Ile Asp Lys Gly Gln Thr Ile Pro Glu 
                85                  90                  95      


Asp Ile Leu Gly Lys Ile Ala Val Ser Ile Val Lys Ala Leu Glu His 
            100                 105                 110         


Leu His Ser Lys Leu Ser Val Ile His Arg Asp Val Lys Pro Ser Asn 
        115                 120                 125             


Val Leu Ile Asn Ala Leu Gly Gln Val Lys Met Cys Asp Phe Gly Ile 
    130                 135                 140                 


Ser Gly Tyr Leu Val Asp Ser Val Ala Lys Thr Ile Asp Ala Gly Cys 
145                 150                 155                 160 


Lys Pro Tyr Met Ala Pro Glu Arg Ile Asn Pro Glu Leu Asn Gln Lys 
                165                 170                 175     


Gly Tyr Ser Val Lys Ser Asp Ile Trp Ser Leu Gly Ile Thr Met Ile 
            180                 185                 190         


Glu Leu Ala Ile Leu Arg Phe Pro Tyr Asp Ser Trp Gly Thr Pro Phe 
        195                 200                 205             


Gln Gln Leu Lys Gln Val Val Glu Glu Pro Ser Pro Gln Leu Pro Ala 
    210                 215                 220                 


Asp Lys Phe Ser Ala Glu Phe Val Asp Phe Thr Ser Gln Cys Leu Lys 
225                 230                 235                 240 


Lys Asn Ser Lys Glu Arg Pro Thr Tyr Pro Glu Leu Met Gln His Pro 
                245                 250                 255     


Phe Phe Thr Leu His Glu Ser Lys Gly Thr Asp Val Ala Ser Phe Val 
            260                 265                 270         


Lys Leu Ile Leu Gly Asp 
        275             


<210>  186
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ser Asp Gly Asn Pro Glu Leu Leu Ser Thr Ser Gln Thr Tyr Asn 
1               5                   10                  15      


Gly Gln Ser Glu Asn Asn Glu Asp Tyr Glu Ile Pro Pro Ile Thr Pro 
            20                  25                  30          


Pro Asn Leu Pro Glu Pro Ser Leu Leu His Leu Gly Asp His Glu Ala 
        35                  40                  45              


Ser Tyr His Ser Leu Cys His Gly Leu Thr Pro Asn Gly Leu Leu Pro 
    50                  55                  60                  


Ala Tyr Ser Tyr Gln Ala Met Asp Leu Pro Ala Ile Met Val Ser Asn 
65                  70                  75                  80  


Met Leu Ala Gln Asp Ser His Leu Leu Ser Gly Gln Leu Pro Thr Ile 
                85                  90                  95      


Gln Glu Met Val His Ser Glu Val Ala Ala Tyr Asp Ser Gly Arg Pro 
            100                 105                 110         


Gly Pro Leu Leu Gly Arg Pro Ala Met Leu Ala Ser His Met Ser Ala 
        115                 120                 125             


Leu Ser Gln Ser Gln Leu Ile Ser Gln Met Gly Ile Arg Ser Ser Ile 
    130                 135                 140                 


Ala His Ser Ser Pro Ser Pro Pro Gly Ser Lys Ser Ala Thr Pro Ser 
145                 150                 155                 160 


Pro Ser Ser Ser Thr Gln Glu Glu Glu Ser Glu Val His Phe Lys Ile 
                165                 170                 175     


Ser Gly Glu Lys Arg Pro Ser Ala Asp Pro Gly Lys Lys Ala Lys Asn 
            180                 185                 190         


Pro Lys Lys Lys Lys Lys Lys Asp Pro Asn Glu Pro Gln Lys Pro Val 
        195                 200                 205             


Ser Ala Tyr Ala Leu Phe Phe Arg Asp Thr Gln Ala Ala Ile Lys Gly 
    210                 215                 220                 


Gln Asn Pro Ser Ala Thr Phe Gly Asp Val Ser Lys Ile Val Ala Ser 
225                 230                 235                 240 


Met Trp Asp Ser Leu Gly Glu Glu Gln Lys Gln Ala Tyr Lys Arg Lys 
                245                 250                 255     


Thr Glu Ala Ala Lys Lys Glu Tyr Leu Lys Ala Leu Ala Ala Tyr Arg 
            260                 265                 270         


Ala Ser Leu Val Ser Lys Ser Ser Pro Asp Gln Gly Glu Thr Lys Ser 
        275                 280                 285             


Thr Gln Ala Asn Pro Pro Ala Lys Met Leu Pro Pro Lys Gln Pro Met 
    290                 295                 300                 


Tyr Ala Met Pro Gly Leu Ala Ser Phe Leu Thr Pro Ser Asp Leu Gln 
305                 310                 315                 320 


Ala Phe Arg Ser Gly Ala Ser Pro Ala Ser Leu Ala Arg Thr Leu Gly 
                325                 330                 335     


Ser Lys Ser Leu Leu Pro Gly Leu Ser Ala Ser Pro Pro Pro Pro Pro 
            340                 345                 350         


Ser Phe Pro Leu Ser Pro Thr Leu His Gln Gln Leu Ser Leu Pro Pro 
        355                 360                 365             


His Ala Gln Gly Ala Leu Leu Ser Pro Pro Val Ser Met Ser Pro Ala 
    370                 375                 380                 


Pro Gln Pro Pro Val Leu Pro Thr Pro Met Ala Leu Gln Val Gln Leu 
385                 390                 395                 400 


Ala Met Ser Pro Ser Pro Pro Gly Pro Gln Asp Phe Pro His Ile Ser 
                405                 410                 415     


Glu Phe Pro Ser Ser Ser Gly Ser Cys Ser Pro Gly Pro Ser Asn Pro 
            420                 425                 430         


Thr Ser Ser Gly Asp Trp Asp Ser Ser Tyr Pro Ser Gly Glu Cys Gly 
        435                 440                 445             


Ile Ser Thr Cys Ser Leu Leu Pro Arg Asp Lys Ser Leu Tyr Leu Thr 
    450                 455                 460                 


<210>  187
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Ile Asp Leu Ser Phe Leu Thr Glu Glu Glu Gln Glu Ala Ile Met 
1               5                   10                  15      


Lys Val Leu Gln Arg Asp Ala Ala Leu Lys Arg Ala Glu Glu Glu Arg 
            20                  25                  30          


Val Arg His Leu Pro Glu Lys Ile Lys Asp Asp Gln Gln Leu Lys Asn 
        35                  40                  45              


Met Ser Gly Gln Trp Phe Tyr Glu Ala Lys Ala Lys Arg His Arg Asp 
    50                  55                  60                  


Lys Ile His Gly Ala Asp Ile Ile Arg Ala Ser Met Arg Lys Lys Arg 
65                  70                  75                  80  


Pro Gln Ile Ala Ala Glu Gln Ser Lys Asp Arg Glu Asn Gly Ala Lys 
                85                  90                  95      


Glu Ser Trp Val Asn Asn Val Asn Lys Asp Ala Phe Leu Pro Pro Glu 
            100                 105                 110         


Leu Ala Gly Val Val Glu Glu Pro Glu Glu Asp Ala Ala Pro Ala Ser 
        115                 120                 125             


Pro Ser Ser Ser Val Val Asn Pro Ala Ser Ser Val Ile Asp Met Ser 
    130                 135                 140                 


Gln Glu Asn Thr Arg Lys Pro Asn Val Ser Pro Glu Lys Arg Lys Asn 
145                 150                 155                 160 


Pro Phe Asn Ser Ser Lys Leu Pro Glu Gly His Ser Ser Gln Gln Thr 
                165                 170                 175     


Lys Asn Glu Gln Ser Lys Asn Gly Arg Thr Gly Leu Phe Gln Thr Ser 
            180                 185                 190         


Lys Glu Asp Glu Leu Ser Glu Ser Lys Glu Lys Ser Thr Val Ala Asp 
        195                 200                 205             


Thr Ser Ile Gln Lys Leu Glu Lys Ser Lys Gln Thr Leu Pro Gly Leu 
    210                 215                 220                 


Ser Asn Gly Ser Gln Ile Lys Ala Pro Ile Pro Lys Ala Arg Lys Met 
225                 230                 235                 240 


Ile Tyr Lys Ser Thr Asp Leu Asn Lys Asp Asp Asn Gln Ser Phe Pro 
                245                 250                 255     


Arg Gln Arg Thr Asp Ser Leu Lys Ala Arg Gly Ala Pro Arg Gly Ile 
            260                 265                 270         


Leu Lys Arg Asn Ser Ser Ser Ser Ser Thr Asp Ser Glu Thr Leu Arg 
        275                 280                 285             


Tyr Asn His Asn Phe Glu Pro Lys Ser Lys Ile Val Ser Pro Gly Leu 
    290                 295                 300                 


Thr Ile His Glu Arg Ile Ser Glu Lys Glu His Ser Leu Glu Asp Asn 
305                 310                 315                 320 


Ser Ser Pro Asn Ser Leu Glu Pro Leu Lys His Val Arg Phe Ser Ala 
                325                 330                 335     


Val Lys Asp Glu Leu Pro Gln Ser Pro Gly Leu Ile His Gly Arg Glu 
            340                 345                 350         


Val Gly Glu Phe Ser Val Leu Glu Ser Asp Arg Leu Lys Asn Gly Met 
        355                 360                 365             


Glu Asp Ala Gly Asp Thr Glu Glu Phe Gln Ser Asp Pro Lys Pro Ser 
    370                 375                 380                 


Gln Tyr Arg Lys Pro Ser Leu Phe His Gln Ser Thr Ser Ser Pro Tyr 
385                 390                 395                 400 


Val Ser Lys Ser Glu Thr His Gln Pro Met Thr Ser Gly Ser Phe Pro 
                405                 410                 415     


Ile Asn Gly Leu His Ser His Ser Glu Val Leu Thr Ala Arg Pro Gln 
            420                 425                 430         


Ser Met Glu Asn Ser Pro Thr Ile Asn Glu Pro Lys Asp Lys Ser Ser 
        435                 440                 445             


Glu Leu Thr Arg Leu Glu Ser Val Leu Pro Arg Ser Pro Ala Asp Glu 
    450                 455                 460                 


Leu Ser His Cys Val Glu Pro Glu Pro Ser Gln Val Pro Gly Gly Ser 
465                 470                 475                 480 


Ser Arg Asp Arg Gln Gln Gly Ser Glu Glu Glu Pro Ser Pro Val Leu 
                485                 490                 495     


Lys Thr Leu Glu Arg Ser Ala Ala Arg Lys Met Pro Ser Lys Ser Leu 
            500                 505                 510         


Glu Asp Ile Ser Ser Asp Ser Ser Asn Gln Ala Lys Val Asp Asn Gln 
        515                 520                 525             


Pro Glu Glu Leu Val Arg Ser Ala Glu Asp Asp Glu Lys Pro Asp Gln 
    530                 535                 540                 


Lys Pro Val Thr Asn Glu Cys Val Pro Arg Ile Ser Thr Val Pro Thr 
545                 550                 555                 560 


Gln Pro Asp Asn Pro Phe Ser His Pro Asp Lys Leu Lys Arg Met Ser 
                565                 570                 575     


Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Val Ser Gly Ser Val Met 
            580                 585                 590         


Ser Val Tyr Ser Gly Asp Phe Gly Asn Leu Glu Val Lys Gly Asn Ile 
        595                 600                 605             


Gln Phe Ala Ile Glu Tyr Val Glu Ser Leu Lys Glu Leu His Val Phe 
    610                 615                 620                 


Val Ala Gln Cys Lys Asp Leu Ala Ala Ala Asp Val Lys Lys Gln Arg 
625                 630                 635                 640 


Ser Asp Pro Tyr Val Lys Ala Tyr Leu Leu Pro Asp Lys Gly Lys Met 
                645                 650                 655     


Gly Lys Lys Lys Thr Leu Val Val Lys Lys Thr Leu Asn Pro Val Tyr 
            660                 665                 670         


Asn Glu Ile Leu Arg Tyr Lys Ile Glu Lys Gln Ile Leu Lys Thr Gln 
        675                 680                 685             


Lys Leu Asn Leu Ser Ile Trp His Arg Asp Thr Phe Lys Arg Asn Ser 
    690                 695                 700                 


Phe Leu Gly Glu Val Glu Leu Asp Leu Glu Thr Trp Asp Trp Asp Asn 
705                 710                 715                 720 


Lys Gln Asn Lys Gln Leu Arg Trp Tyr Pro Leu Lys Arg Lys Thr Ala 
                725                 730                 735     


Pro Val Ala Leu Glu Ala Glu Asn Arg Gly Glu Met Lys Leu Ala Leu 
            740                 745                 750         


Gln Tyr Val Pro Glu Pro Val Pro Gly Lys Lys Leu Pro Thr Thr Gly 
        755                 760                 765             


Glu Val His Ile Trp Val Lys Glu Cys Leu Asp Leu Pro Leu Leu Arg 
    770                 775                 780                 


Gly Ser His Leu Asn Ser Phe Val Lys Cys Thr Ile Leu Pro Asp Thr 
785                 790                 795                 800 


Ser Arg Lys Ser Arg Gln Lys Thr Arg Ala Val Gly Lys Thr Thr Asn 
                805                 810                 815     


Pro Ile Phe Asn His Thr Met Val Tyr Asp Gly Phe Arg Pro Glu Asp 
            820                 825                 830         


Leu Met Glu Ala Cys Val Glu Leu Thr Val Trp Asp His Tyr Lys Leu 
        835                 840                 845             


Thr Asn Gln Phe Leu Gly Gly Leu Arg Ile Gly Phe Gly Thr Gly Lys 
    850                 855                 860                 


Ser Tyr Gly Thr Glu Val Asp Trp Met Asp Ser Thr Ser Glu Glu Val 
865                 870                 875                 880 


Ala Leu Trp Glu Lys Met Val Asn Ser Pro Asn Thr Trp Ile Glu Ala 
                885                 890                 895     


Thr Leu Pro Leu Arg Met Leu Leu Ile Ala Lys Ile Ser Lys 
            900                 905                 910 


<210>  188
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Pro Arg Ala Gln Pro Ser Ser Ala Ser Tyr Gln Pro Val Pro Ala 
1               5                   10                  15      


Asp Pro Phe Ala Ile Val Ser Arg Ala Gln Gln Met Val Glu Ile Leu 
            20                  25                  30          


Ser Asp Glu Asn Arg Asn Leu Arg Gln Glu Leu Glu Gly Cys Tyr Glu 
        35                  40                  45              


Lys Val Ala Arg Leu Gln Lys Val Glu Thr Glu Ile Gln Arg Val Ser 
    50                  55                  60                  


Glu Ala Tyr Glu Asn Leu Val Lys Ser Ser Ser Lys Arg Glu Ala Leu 
65                  70                  75                  80  


Glu Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Met His 
                85                  90                  95      


Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Thr Ala Asn Lys Gln 
            100                 105                 110         


Leu Ala Glu Lys Glu Tyr Glu Gly Ser Glu Asp Thr Arg Lys Thr Ile 
        115                 120                 125             


Ser Gln Leu Phe Ala Lys Asn Lys Glu Ser Gln Arg Glu Lys Glu Lys 
    130                 135                 140                 


Leu Glu Ala Glu Leu Ala Thr Ala Arg Ser Thr Asn Glu Asp Gln Arg 
145                 150                 155                 160 


Arg His Ile Glu Ile Arg Asp Gln Ala Leu Ser Asn Ala Gln Ala Lys 
                165                 170                 175     


Val Val Lys Leu Glu Glu Glu Leu Lys Lys Lys Gln Val Tyr Val Asp 
            180                 185                 190         


Lys Val Glu Lys Met Gln Gln Ala Leu Val Gln Leu Gln Ala Ala Cys 
        195                 200                 205             


Glu Lys Arg Glu Gln Leu Glu His Arg Leu Arg Thr Arg Leu Glu Arg 
    210                 215                 220                 


Glu Leu Glu Ser Leu Arg Ile Gln Gln Arg Gln Gly Asn Cys Gln Pro 
225                 230                 235                 240 


Thr Asn Val Ser Glu Tyr Asn Ala Ala Ala Leu Met Glu Leu Leu Arg 
                245                 250                 255     


Glu Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Thr Lys Trp 
            260                 265                 270         


Glu Gln Lys Tyr Leu Glu Glu Asn Val Met Arg His Phe Ala Leu Asp 
        275                 280                 285             


Ala Ala Ala Thr Val Ala Ala Gln Arg Asp Thr Thr Val Ile Ser His 
    290                 295                 300                 


Ser Pro Asn Thr Ser Tyr Asp Thr Ala Leu Glu Ala Arg Ile Gln Lys 
305                 310                 315                 320 


Glu Glu Glu Glu Ile Leu Met Ala Asn Lys Arg Cys Leu Asp Met Glu 
                325                 330                 335     


Gly Arg Ile Lys Thr Leu His Ala Gln Ile Ile Glu Lys Asp Ala Met 
            340                 345                 350         


Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Glu Pro Ser Lys Thr Glu 
        355                 360                 365             


Gln Leu Ser Cys Met Arg Pro Ala Lys Ser Leu Met Ser Ile Ser Asn 
    370                 375                 380                 


Ala Gly Ser Gly Leu Leu Ser His Ser Ser Thr Leu Thr Gly Ser Pro 
385                 390                 395                 400 


Ile Met Glu Glu Lys Arg Asp Asp Lys Ser Trp Lys Gly Ser Leu Gly 
                405                 410                 415     


Ile Leu Leu Gly Gly Asp Tyr Arg Ala Glu Tyr Val Pro Ser Thr Pro 
            420                 425                 430         


Ser Pro Val Pro Pro Ser Thr Pro Leu Leu Ser Ala His Ser Lys Thr 
        435                 440                 445             


Gly Ser Arg Asp Cys Ser Thr Gln Thr Glu Arg Gly Thr Glu Ser Asn 
    450                 455                 460                 


Lys Thr Ala Ala Val Ala Pro Ile Ser Val Pro Ala Pro Val Ala Ala 
465                 470                 475                 480 


Ala Ala Thr Ala Ala Ala Ile Thr Ala Thr Ala Ala Thr Ile Thr Thr 
                485                 490                 495     


Thr Met Val Ala Ala Ala Pro Val Ala Val Ala Ala Ala Ala Ala Pro 
            500                 505                 510         


Ala Ala Ala Ala Ala Pro Ser Pro Ala Thr Ala Ala Ala Thr Ala Ala 
        515                 520                 525             


Ala Val Ser Pro Ala Ala Ala Gly Gln Ile Pro Ala Ala Ala Ser Val 
    530                 535                 540                 


Ala Ser Ala Ala Ala Val Ala Pro Ser Ala Ala Ala Ala Ala Ala Val 
545                 550                 555                 560 


Gln Val Ala Pro Ala Ala Pro Ala Pro Val Pro Ala Pro Ala Leu Val 
                565                 570                 575     


Pro Val Pro Ala Pro Ala Ala Ala Gln Ala Ser Ala Pro Ala Gln Thr 
            580                 585                 590         


Gln Ala Pro Thr Ser Ala Pro Ala Val Ala Pro Thr Pro Ala Pro Thr 
        595                 600                 605             


Pro Thr Pro Ala Val Ala Gln Ala Glu Val Pro Ala Ser Pro Ala Thr 
    610                 615                 620                 


Gly Pro Gly Pro His Arg Leu Ser Ile Pro Ser Leu Thr Cys Asn Pro 
625                 630                 635                 640 


Asp Lys Thr Asp Gly Pro Val Phe His Ser Asn Thr Leu Glu Arg Lys 
                645                 650                 655     


Thr Pro Ile Gln Ile Leu Gly Gln Glu Pro Asp Ala Glu Met Val Glu 
            660                 665                 670         


Tyr Leu Ile 
        675 


<210>  189
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp 
1               5                   10                  15      


Ala Gly Ala Asp Asp Trp Glu Thr Asp Pro Asp Phe Val Asn Asp Val 
            20                  25                  30          


Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Val Gln Gly Ser Gly 
        35                  40                  45              


His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln 
    50                  55                  60                  


Glu His Gln Thr Leu Lys Glu Lys Glu Leu Glu Thr Gly Pro Lys Ala 
65                  70                  75                  80  


Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp 
                85                  90                  95      


Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys 
            100                 105                 110         


Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln 
        115                 120                 125             


Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys 
    130                 135                 140                 


Thr Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly 
145                 150                 155                 160 


Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe 
                165                 170                 175     


Asp Tyr Gln Gly Lys Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ser 
            180                 185                 190         


Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys 
        195                 200                 205             


Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Thr Glu Lys His Glu Ser 
    210                 215                 220                 


Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Thr 
225                 230                 235                 240 


Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu 
                245                 250                 255     


Gln Leu His Glu Ser Gln Lys Asp Tyr Ser Lys Gly Phe Gly Gly Lys 
            260                 265                 270         


Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn Ala Ser Thr Phe Glu 
        275                 280                 285             


Asp Val Thr Gln Val Ser Ser Ala Tyr Gln Lys Thr Val Pro Val Glu 
    290                 295                 300                 


Ala Val Thr Ser Lys Thr Ser Asn Ile Arg Ala Asn Phe Glu Asn Leu 
305                 310                 315                 320 


Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys Ala Glu Ala Glu Arg 
                325                 330                 335     


Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln Glu Glu Ala Arg Arg 
            340                 345                 350         


Lys Leu Glu Glu Gln Ala Arg Ala Lys Thr Gln Thr Pro Pro Val Ser 
        355                 360                 365             


Pro Ala Pro Gln Pro Thr Glu Glu Arg Leu Pro Ser Ser Pro Val Tyr 
    370                 375                 380                 


Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser Tyr Arg Gly Pro Val 
385                 390                 395                 400 


Ser Gly Thr Glu Pro Glu Pro Val Tyr Ser Met Glu Ala Ala Asp Tyr 
                405                 410                 415     


Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr Ala Thr Glu Ala Val 
            420                 425                 430         


Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro Ala Glu Asp Ser Thr 
        435                 440                 445             


Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Ile Thr Ala Val Ala Leu Tyr 
    450                 455                 460                 


Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser Phe Asp Pro Asp Asp 
465                 470                 475                 480 


Ile Ile Thr Asn Ile Glu Met Ile Asp Asp Gly Trp Trp Arg Gly Val 
                485                 490                 495     


Cys Lys Gly Arg Tyr Gly Leu Phe Pro Ala Asn Tyr Val Glu Leu Arg 
            500                 505                 510         


Gln 
    


<210>  190
<211>  1205
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Thr Lys Lys Glu Glu Pro Pro Pro Ser Arg Val Pro Arg Ala Val 
1               5                   10                  15      


Arg Val Ala Ser Leu Leu Ser Glu Gly Glu Glu Leu Ser Gly Asp Asp 
            20                  25                  30          


Gln Gly Asp Glu Glu Glu Asp Asp His Ala Tyr Glu Gly Val Pro Asn 
        35                  40                  45              


Gly Gly Trp His Thr Ser Ser Leu Ser Leu Ser Leu Pro Ser Thr Ile 
    50                  55                  60                  


Ala Ala Pro His Pro Met Asp Gly Pro Pro Gly Gly Ser Thr Pro Val 
65                  70                  75                  80  


Thr Pro Val Ile Lys Ala Gly Trp Leu Asp Lys Asn Pro Pro Gln Gly 
                85                  90                  95      


Ser Tyr Ile Tyr Gln Lys Arg Trp Val Arg Leu Asp Thr Asp His Leu 
            100                 105                 110         


Arg Tyr Phe Asp Ser Asn Lys Asp Ala Tyr Ser Lys Arg Phe Ile Ser 
        115                 120                 125             


Val Ala Cys Ile Ser His Val Ala Ala Ile Gly Asp Gln Lys Phe Glu 
    130                 135                 140                 


Val Ile Thr Asn Asn Arg Thr Phe Ala Phe Arg Ala Glu Ser Asp Val 
145                 150                 155                 160 


Glu Arg Lys Glu Trp Met Gln Ala Leu Gln Gln Ala Met Ala Glu Gln 
                165                 170                 175     


Arg Ala Arg Ala Arg Leu Ser Ser Ala Tyr Leu Leu Gly Val Pro Gly 
            180                 185                 190         


Ser Glu Gln Pro Asp Arg Ala Gly Ser Leu Glu Leu Arg Gly Phe Lys 
        195                 200                 205             


Asn Lys Leu Tyr Val Ala Val Val Gly Asp Lys Val Gln Leu Tyr Lys 
    210                 215                 220                 


Asn Leu Glu Glu Tyr His Leu Gly Ile Gly Ile Thr Phe Ile Asp Met 
225                 230                 235                 240 


Ser Val Gly Asn Val Lys Glu Val Asp Arg Arg Ser Phe Asp Leu Thr 
                245                 250                 255     


Thr Pro Tyr Arg Ile Phe Ser Phe Ser Ala Asp Ser Glu Leu Glu Lys 
            260                 265                 270         


Glu Gln Trp Leu Glu Ala Met Gln Gly Ala Ile Ala Glu Ala Leu Ser 
        275                 280                 285             


Thr Ser Glu Val Ala Glu Arg Ile Trp Ala Ala Ala Pro Asn Arg Phe 
    290                 295                 300                 


Cys Ala Asp Cys Gly Ala Pro Gln Pro Asp Trp Ala Ser Ile Asn Leu 
305                 310                 315                 320 


Cys Val Val Ile Cys Lys Arg Cys Ala Gly Glu His Arg Gly Leu Gly 
                325                 330                 335     


Ala Gly Val Ser Lys Val Arg Ser Leu Lys Met Asp Arg Lys Val Trp 
            340                 345                 350         


Thr Glu Thr Leu Ile Glu Leu Phe Leu Gln Leu Gly Asn Gly Ala Gly 
        355                 360                 365             


Asn Arg Phe Trp Ala Ala Asn Val Pro Pro Ser Glu Ala Leu Gln Pro 
    370                 375                 380                 


Ser Ser Ser Pro Ser Thr Arg Arg Cys His Leu Glu Ala Lys Tyr Arg 
385                 390                 395                 400 


Glu Gly Lys Tyr Arg Arg Tyr His Pro Leu Phe Gly Asn Gln Glu Glu 
                405                 410                 415     


Leu Asp Lys Ala Leu Cys Ala Ala Val Thr Thr Thr Asp Leu Ala Glu 
            420                 425                 430         


Thr Gln Ala Leu Leu Gly Cys Gly Ala Gly Ile Asn Cys Phe Ser Gly 
        435                 440                 445             


Asp Pro Glu Ala Pro Thr Pro Leu Ala Leu Ala Glu Gln Ala Gly Gln 
    450                 455                 460                 


Thr Leu Gln Met Glu Phe Leu Arg Asn Asn Arg Thr Thr Glu Val Pro 
465                 470                 475                 480 


Arg Leu Asp Ser Met Lys Pro Leu Glu Lys His Tyr Ser Val Val Leu 
                485                 490                 495     


Pro Thr Val Ser His Ser Gly Phe Leu Tyr Lys Thr Ala Ser Ala Gly 
            500                 505                 510         


Lys Leu Leu Gln Asp Arg Arg Ala Arg Glu Glu Phe Ser Arg Arg Trp 
        515                 520                 525             


Cys Val Leu Gly Asp Gly Val Leu Ser Tyr Phe Glu Asn Glu Arg Ala 
    530                 535                 540                 


Val Thr Pro Asn Gly Glu Ile Arg Ala Ser Glu Ile Val Cys Leu Ala 
545                 550                 555                 560 


Val Pro Pro Pro Asp Thr His Gly Phe Glu His Thr Phe Glu Val Tyr 
                565                 570                 575     


Thr Glu Gly Glu Arg Leu Tyr Leu Phe Gly Leu Glu Ser Ala Glu Gln 
            580                 585                 590         


Ala His Glu Trp Val Lys Cys Ile Ala Lys Ala Phe Val Pro Pro Leu 
        595                 600                 605             


Ala Glu Asp Leu Leu Ala Arg Asp Phe Glu Arg Leu Gly Arg Leu Pro 
    610                 615                 620                 


Tyr Lys Ala Gly Leu Ser Leu Gln Arg Ala Gln Glu Gly Trp Phe Ser 
625                 630                 635                 640 


Leu Ser Gly Ser Glu Leu Arg Ala Val Phe Pro Glu Gly Pro Cys Glu 
                645                 650                 655     


Glu Pro Leu Gln Leu Arg Lys Leu Gln Glu Leu Ser Ile Gln Gly Asp 
            660                 665                 670         


Ser Glu Asn Gln Val Leu Val Leu Val Glu Arg Arg Arg Thr Leu Tyr 
        675                 680                 685             


Ile Gln Gly Glu Arg Arg Leu Asp Phe Met Gly Trp Leu Gly Ala Ile 
    690                 695                 700                 


Gln Lys Ala Ala Ala Ser Met Gly Asp Thr Leu Ser Glu Gln Gln Leu 
705                 710                 715                 720 


Gly Asp Ser Asp Ile Pro Val Ile Val Tyr Arg Cys Val Asp Tyr Ile 
                725                 730                 735     


Thr Gln Cys Gly Leu Thr Ser Glu Gly Ile Tyr Arg Lys Cys Gly Gln 
            740                 745                 750         


Thr Ser Lys Thr Gln Arg Leu Leu Glu Ser Leu Arg Gln Asp Ala Arg 
        755                 760                 765             


Ser Val His Leu Lys Glu Gly Glu Gln His Val Asp Asp Val Ser Ser 
    770                 775                 780                 


Ala Leu Lys Arg Phe Leu Arg Asp Leu Pro Asp Gly Leu Phe Thr Arg 
785                 790                 795                 800 


Ala Gln Arg Leu Thr Trp Leu Glu Ala Ser Glu Ile Glu Asp Glu Glu 
                805                 810                 815     


Glu Lys Val Ser Arg Tyr Arg Glu Leu Leu Val Arg Leu Pro Pro Val 
            820                 825                 830         


Asn Arg Ala Thr Val Lys Ala Leu Ile Ser His Leu Tyr Cys Val Gln 
        835                 840                 845             


Cys Phe Ser Asp Thr Asn Gln Met Asn Val His Asn Leu Ala Ile Val 
    850                 855                 860                 


Phe Gly Pro Thr Leu Phe Gln Thr Asp Gly Gln Asp Tyr Lys Ala Gly 
865                 870                 875                 880 


Arg Val Val Glu Asp Leu Ile Asn His Tyr Val Val Val Phe Ser Val 
                885                 890                 895     


Asp Glu Glu Glu Leu Arg Lys Gln Arg Glu Glu Ile Thr Ala Ile Val 
            900                 905                 910         


Lys Met Arg Val Ala Gly Thr Ala Ser Gly Thr Gln His Ala Gly Asp 
        915                 920                 925             


Phe Ile Cys Thr Val Tyr Leu Glu Glu Lys Lys Ala Glu Thr Glu Gln 
    930                 935                 940                 


His Ile Lys Val Pro Ala Ser Met Thr Ala Glu Glu Leu Thr Leu Glu 
945                 950                 955                 960 


Ile Leu Asp Arg Arg Asn Val Gly Ile Arg Glu Lys Asp Tyr Trp Thr 
                965                 970                 975     


Cys Phe Glu Val Asn Glu Arg Glu Glu Ala Glu Arg Pro Leu His Phe 
            980                 985                 990         


Ala Glu Lys Val Leu Pro Ile Leu  His Gly Leu Gly Thr  Asp Ser His 
        995                 1000                 1005             


Leu Val  Val Lys Lys His Gln  Ala Met Glu Ala Met  Leu Leu Tyr 
    1010                 1015                 1020             


Leu Ala  Ser Arg Val Gly Asp  Thr Lys His Gly Met  Met Lys Phe 
    1025                 1030                 1035             


Arg Glu  Asp Arg Ser Leu Leu  Gly Leu Gly Leu Pro  Ser Gly Gly 
    1040                 1045                 1050             


Phe His  Asp Arg Tyr Phe Ile  Leu Asn Ser Ser Cys  Leu Arg Leu 
    1055                 1060                 1065             


Tyr Lys  Glu Val Arg Ser Gln  Arg Pro Trp Ser Gly  Ala Pro Glu 
    1070                 1075                 1080             


Thr Ser  His Arg Pro Glu Lys  Glu Trp Pro Ile Lys  Ser Leu Lys 
    1085                 1090                 1095             


Val Tyr  Leu Gly Val Lys Lys  Lys Leu Arg Pro Pro  Thr Cys Trp 
    1100                 1105                 1110             


Gly Phe  Thr Val Val His Glu  Thr Glu Lys His Glu  Lys Gln Gln 
    1115                 1120                 1125             


Trp Tyr  Leu Cys Cys Asp Thr  Gln Met Glu Leu Arg  Glu Trp Phe 
    1130                 1135                 1140             


Ala Thr  Phe Leu Phe Val Gln  His Asp Gly Leu Val  Trp Pro Ser 
    1145                 1150                 1155             


Glu Pro  Ser Arg Val Ser Arg  Ala Val Pro Glu Val  Arg Leu Gly 
    1160                 1165                 1170             


Ser Val  Ser Leu Ile Pro Leu  Arg Gly Ser Glu Asn  Glu Met Arg 
    1175                 1180                 1185             


Arg Ser  Val Ala Ala Phe Thr  Ala Asp Pro Leu Ser  Leu Leu Arg 
    1190                 1195                 1200             


Asn Val  
    1205 


<210>  191
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Leu Ala Gly Gln Leu Glu Ala Arg Asp Pro Lys Glu Gly Thr His 
1               5                   10                  15      


Pro Glu Asp Pro Cys Pro Gly Ala Gly Ala Val Met Glu Lys Thr Ala 
            20                  25                  30          


Val Ala Ala Glu Val Leu Thr Glu Asp Cys Asn Thr Gly Glu Met Pro 
        35                  40                  45              


Pro Leu Gln Gln Gln Ile Ile Arg Leu His Gln Glu Leu Gly Arg Gln 
    50                  55                  60                  


Lys Ser Leu Trp Ala Asp Val His Gly Lys Leu Arg Ser His Ile Asp 
65                  70                  75                  80  


Ala Leu Arg Glu Gln Asn Met Glu Leu Arg Glu Lys Leu Arg Ala Leu 
                85                  90                  95      


Gln Leu Gln Arg Trp Lys Ala Arg Lys Lys Ser Ala Ala Ser Pro His 
            100                 105                 110         


Ala Gly Gln Glu Ser His Thr Leu Ala Leu Glu Pro Ala Phe Gly Lys 
        115                 120                 125             


Ile Ser Pro Leu Ser Ala Asp Glu Glu Thr Ile Pro Lys Tyr Ala Gly 
    130                 135                 140                 


His Lys Asn Gln Ser Ala Thr Leu Leu Gly Gln Arg Ser Ser Ser Asn 
145                 150                 155                 160 


Asn Ser Ala Pro Pro Lys Pro Met Ser Leu Lys Ile Glu Arg Ile Ser 
                165                 170                 175     


Ser Trp Lys Thr Pro Pro Gln Glu Asn Arg Asp Lys Asn Leu Ser Arg 
            180                 185                 190         


Arg Arg Gln Asp Arg Arg Ala Thr Pro Thr Gly Arg Pro Thr Pro Cys 
        195                 200                 205             


Ala Glu Arg Arg Gly Gly Val 
    210                 215 


<210>  192
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Asp Glu Ala Asp Phe Ser Glu His Thr Thr Tyr Lys Gln Glu Asp 
1               5                   10                  15      


Leu Pro Tyr Asp Gly Asp Leu Ser Gln Ile Lys Ile Gly Asn Asp Tyr 
            20                  25                  30          


Ser Phe Thr Ser Lys Lys Asp Gly Leu Glu Val Leu Asn Gln Ile Ile 
        35                  40                  45              


Phe Ile Ala Asp Asp Pro Gln Glu Lys Ala Met His Ser Glu Thr Cys 
    50                  55                  60                  


Gly Asn Thr Ala Val Thr Ile Pro Leu Gly Lys Ile Thr Glu Asn Ala 
65                  70                  75                  80  


Ala Asn Lys Lys Asp Glu Lys Glu Lys Gln Cys Thr Ala Ala Leu His 
                85                  90                  95      


Ile Pro Ala Asn Glu Gly Asp Ala Ser Lys Ser Ser Ile Ser Asp Ile 
            100                 105                 110         


Leu Leu His His Leu Ser Lys Glu Pro Phe Leu Arg Gly Gln Gly Ile 
        115                 120                 125             


Asp Cys Glu Thr Leu Pro Glu Ile Ser Asn Ala Asp Ser Phe Glu Glu 
    130                 135                 140                 


Glu Ala Ile Ile Lys Ser Ile Ile Ser Cys Tyr Asn Lys Asn Ser Trp 
145                 150                 155                 160 


Pro Lys Glu Gln Thr Pro Gly Leu Thr Asp Gln Leu Asn Pro Lys Arg 
                165                 170                 175     


Asp Gly Glu Asn Ser Asn Lys Pro Gly Ser Ala Thr Thr Thr Glu Glu 
            180                 185                 190         


Asn Thr Ser Asp Leu Glu Gly Pro Val Ala Ala Gly Asp Ser Ser His 
        195                 200                 205             


Gln Glu Asn Val Asn Val Leu Thr Lys Thr Lys Gly Pro Gly Asp Lys 
    210                 215                 220                 


Gln Lys Ser Tyr Gln Gly Gln Ser Pro Gln Lys Gln Gln Thr Glu Lys 
225                 230                 235                 240 


Ala Asn Ser Gly Asn Thr Phe Lys Tyr Gly Gln Gly Gln Val His Tyr 
                245                 250                 255     


Gln Leu Pro Asp Phe Ser Lys Ile Ala Pro Lys Val Lys Ile Pro Lys 
            260                 265                 270         


Asn Lys Ile Ile Asn Lys Pro Leu Ala Ile Ala Lys Gln Ala Ser Phe 
        275                 280                 285             


Ser Ser Lys Ser Arg Asp Lys Pro Thr Leu Val Gln Asp Ser Leu Glu 
    290                 295                 300                 


Thr Thr Pro Glu Ser Asn Cys Val Glu Lys Gln His Gln Glu Gln Lys 
305                 310                 315                 320 


Gly Lys Ile Thr Glu Pro Ser Gln Gln Ile Gln Met Glu Pro Ile Val 
                325                 330                 335     


His Ile His Gln Glu Leu Leu Thr Gly Ile Glu Ser Glu Ala Ser Leu 
            340                 345                 350         


Ser Lys Leu Ser Pro Thr Ser Gln Lys Gly Thr Ser Ser Ser Ser Ser 
        355                 360                 365             


Tyr Ile Phe Gln Lys Ile Ser Gln Gly Lys Gln Met Cys Gln Lys Leu 
    370                 375                 380                 


Lys Glu Gln Thr Asp Gln Leu Lys Thr Lys Val Gln Glu Phe Ser Lys 
385                 390                 395                 400 


Arg Ile Lys Gln Asp Ser Pro Tyr His Leu Gln Asp Lys Lys Leu 
                405                 410                 415 


<210>  193
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Trp Ser Phe Leu Pro Gly Ala Glu Ser Val Ser Met Gly Pro Val 
1               5                   10                  15      


Pro Gly Val Ser Ser Leu Gly Ala Cys Trp Thr His Asp Gln Asp Ser 
            20                  25                  30          


Gly Arg Ala Glu Asp Arg Pro Gln Ala Pro Arg Ile Thr Gln Tyr Thr 
        35                  40                  45              


Trp Val Leu Ser Phe Leu Phe Thr Glu Lys Pro Gln Thr Arg Ser Thr 
    50                  55                  60                  


Ser Pro Ile Ser His Gln Gly Gln Pro Gln Thr Thr Arg Ala Leu Ser 
65                  70                  75                  80  


Leu Arg Gln Pro Gln His Pro Ser Ala Pro Ala Ser Gly Arg Pro Arg 
                85                  90                  95      


Pro Pro His Ser Ser Gly Pro Asp Leu Ala Glu Ala Ala Pro Val Val 
            100                 105                 110         


Asp Gln Ala Ser Gln Ala Ala Gly Arg Ala Ser Ser Gly Leu Gly Leu 
        115                 120                 125             


Trp Glu Gln Ala Ser Val Ser Gln Gly Phe Arg Asn Ala Ala Phe Glu 
    130                 135                 140                 


Ala 
145 


<210>  194
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser Arg 
1               5                   10                  15      


Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His Ser 
            20                  25                  30          


Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser Asn 
        35                  40                  45              


Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg Tyr 
    50                  55                  60                  


Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser Phe 
65                  70                  75                  80  


Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile Asn 
                85                  90                  95      


Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg Lys 
            100                 105                 110         


Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys Ser 
        115                 120                 125             


Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn Pro 
    130                 135                 140                 


Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro Gln 
145                 150                 155                 160 


Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp Phe 
                165                 170                 175     


Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro Arg 
            180                 185                 190         


Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe Glu 
        195                 200                 205             


Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly Val 
    210                 215                 220                 


Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu His 
225                 230                 235                 240 


Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu Lys 
                245                 250                 255     


Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys Arg 
            260                 265                 270         


Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser Pro 
        275                 280                 285             


Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg Ser 
    290                 295                 300                 


Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu Ser 
305                 310                 315                 320 


Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro Gly 
                325                 330                 335     


Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp Asp 
            340                 345                 350         


Ser Asp Ser Leu Gly Asp Ser Met 
        355                 360 


<210>  195
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly 
    130                 135                 140                 


Ser Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 
145                 150                 155                 160 


Pro Glu Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 
                165                 170                 175     


Glu 
    


<210>  196
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
                405                 410                 415     


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
            420                 425                 430         


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
        435                 440                 445             


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
    450                 455                 460                 


Arg Gln 
465     


<210>  197
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Gly Pro Lys Arg Arg Gln Leu Thr Phe Arg Glu Lys Ser Arg Ile 
1               5                   10                  15      


Ile Gln Glu Val Glu Glu Asn Pro Asp Leu Arg Lys Gly Glu Ile Ala 
            20                  25                  30          


Arg Arg Phe Asn Ile Pro Pro Ser Thr Leu Ser Thr Ile Leu Lys Asn 
        35                  40                  45              


Lys Arg Ala Ile Leu Ala Ser Glu Arg Lys Tyr Gly Val Ala Ser Thr 
    50                  55                  60                  


Cys Arg Lys Thr Asn Lys Leu Ser Pro Tyr Asp Lys Leu Glu Gly Leu 
65                  70                  75                  80  


Leu Ile Ala Trp Phe Gln Gln Ile Arg Ala Ala Gly Leu Pro Val Lys 
                85                  90                  95      


Gly Ile Ile Leu Lys Glu Lys Ala Leu Arg Ile Ala Glu Glu Leu Gly 
            100                 105                 110         


Met Asp Asp Phe Thr Ala Ser Asn Gly Trp Leu Asp Arg Phe Arg Arg 
        115                 120                 125             


Arg His Gly Val Val Ser Cys Ser Gly Val Ala Arg Ala Arg Ala Arg 
    130                 135                 140                 


Asn Ala Ala Pro Arg Thr Pro Ala Ala Pro Ala Ser Pro Ala Ala Val 
145                 150                 155                 160 


Pro Ser Glu Gly Ser Gly Gly Ser Thr Thr Gly Trp Arg Ala Arg Glu 
                165                 170                 175     


Glu Gln Pro Pro Ser Val Ala Glu Gly Tyr Ala Ser Gln Asp Val Phe 
            180                 185                 190         


Ser Ala Thr Glu Thr Ser Leu Trp Tyr Asp Phe Leu Pro Asp Gln Ala 
        195                 200                 205             


Ala Gly Leu Cys Gly Gly Asp Gly Arg Pro Arg Gln Ala Thr Gln Arg 
    210                 215                 220                 


Leu Ser Val Leu Leu Cys Ala Asn Ala Asp Gly Ser Glu Lys Leu Pro 
225                 230                 235                 240 


Pro Leu Val Ala Gly Lys Ser Ala Lys Pro Arg Ala Gly Gln Ala Gly 
                245                 250                 255     


Leu Pro Cys Asp Tyr Thr Ala Asn Ser Lys Gly Gly Val Thr Thr Gln 
            260                 265                 270         


Ala Leu Ala Lys Tyr Leu Lys Ala Leu Asp Thr Arg Met Ala Ala Glu 
        275                 280                 285             


Ser Arg Arg Val Leu Leu Leu Ala Gly Arg Leu Ala Ala Gln Ser Leu 
    290                 295                 300                 


Asp Thr Ser Gly Leu Arg His Val Gln Leu Ala Phe Phe Pro Pro Gly 
305                 310                 315                 320 


Thr Val His Pro Leu Glu Arg Gly Val Val Gln Gln Val Lys Gly His 
                325                 330                 335     


Tyr Arg Gln Ala Met Leu Leu Lys Ala Met Ala Ala Leu Glu Gly Gln 
            340                 345                 350         


Asp Pro Ser Gly Leu Gln Leu Gly Leu Thr Glu Ala Leu His Phe Val 
        355                 360                 365             


Ala Ala Ala Trp Gln Ala Val Glu Pro Ser Asp Ile Ala Ala Cys Phe 
    370                 375                 380                 


Arg Glu Ala Gly Phe Gly Gly Gly Pro Asn Ala Thr Ile Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Ser Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                405                 410                 415     


Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu 
            420                 425                 430         


Glu Glu Glu Gly Gly Glu Gly Glu Glu Leu Gly Glu Glu Glu Glu Val 
        435                 440                 445             


Glu Glu Glu Gly Asp Val Asp Ser Asp Glu Glu Glu Glu Glu Asp Glu 
    450                 455                 460                 


Glu Ser Ser Ser Glu Gly Leu Glu Ala Glu Asp Trp Ala Gln Gly Val 
465                 470                 475                 480 


Val Glu Ala Gly Gly Ser Phe Gly Ala Tyr Gly Ala Gln Glu Glu Ala 
                485                 490                 495     


Gln Cys Pro Thr Leu His Phe Leu Glu Gly Gly Glu Asp Ser Asp Ser 
            500                 505                 510         


Asp Ser Glu Glu Glu Asp Asp Glu Glu Glu Asp Asp Glu Asp Glu Asp 
        515                 520                 525             


Asp Asp Asp Asp Glu Glu Asp Gly Asp Glu Val Pro Val Pro Ser Phe 
    530                 535                 540                 


Gly Glu Ala Met Ala Tyr Phe Ala Met Val Lys Arg Tyr Leu Thr Ser 
545                 550                 555                 560 


Phe Pro Ile Asp Asp Arg Val Gln Ser His Ile Leu His Leu Glu His 
                565                 570                 575     


Asp Leu Val His Val Thr Arg Lys Asn His Ala Arg Gln Ala Gly Val 
            580                 585                 590         


Arg Gly Leu Gly His Gln Ser 
        595                 


