                         SEQUENCE LISTING

<110>  Inviragen, Inc.
       THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS 
       REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND 
       HUMAN SERVICES
       Stinchcomb, Dan
       Huang, Claire  Y.
       Kinney, Richard M.
       Livengood, Jill A.
 
<120>  COMPOSITIONS AND METHODS FOR DENGUE VIRUS CHIMERIC CONSTRUCTS IN 
       VACCINES

<130>  478484.85

<150>  61/800,204
<151>  2013-03-15

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  10723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 1, BVS

<400>  1
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acgcgtgggg gagagccgca tatgatagtt      480

agcaagcagg aaagaggaaa gtcacttttg ttcaagacct ctgcaggtgt caacatgtgc      540

accctcattg cgatggattt gggagagttg tgtgaggaca cgatgaccta caaatgcccc      600

cggatcactg aggcggaacc agatgacgtt gactgttggt gcaatgccac ggacacatgg      660

gtgacctatg gaacgtgctc tcaaactggc gaacaccgac gagacaaacg ttccgtcgca      720

ttggccccac acgtggggct tggcctagaa acaagagccg aaacgtggat gtcctctgaa      780

ggtgcttgga aacagataca aaaagtagag acttgggctc tgagacatcc aggattcacg      840

gtgatagccc tttttctagc acatgccata ggaacatcca tcacccagaa agggatcatt      900

ttcattttgc tgatgctggt aacaccatct atggccatgc gatgcgtggg aataggcaac      960

agagacttcg tggaaggact gtcaggagca acatgggtgg atgtggtact ggagcatgga     1020

agttgcgtca ccaccatggc aaaaaacaaa ccaacactgg acattgaact cttgaagacg     1080

gaggtcacaa accctgcagt tctgcgtaaa ttgtgcattg aagctaaaat atcaaacacc     1140

accaccgatt cgagatgtcc aacacaagga gaagccacac tggtggaaga acaagacgcg     1200

aactttgtgt gccgacgaac gttcgtggac agaggctggg gcaatggctg tgggctattc     1260

ggaaaaggta gtctaataac gtgtgccaag tttaagtgtg tgacaaaact agaaggaaag     1320

atagttcaat atgaaaacct aaaatattca gtgatagtca ccgtccacac tggagatcag     1380

caccaggtgg gaaatgagac tacagaacat ggaacaactg caaccataac acctcaagct     1440

cctacgtcgg aaatacagct gaccgactac ggaaccctta cattagattg ttcacctagg     1500

acagggctag attttaacga gatggtgttg ctgacaatga aagaaagatc atggcttgtc     1560

cacaaacaat ggttcctaga cttaccactg ccttggacct ctggggcttc aacatcccaa     1620

gagacttgga acagacaaga tttactggtc acatttaaga cagctcatgc aaagaagcag     1680

gaagtagtcg tactaggatc acaagaagga gcaatgcaca ctgcgctgac tggagcgaca     1740

gaaatccaaa cgtcaggaac gacaacaatt ttcgcaggac acctaaaatg cagactaaaa     1800

atggacaaac taactttaaa agggatgtca tatgtgatgt gcacaggctc attcaagtta     1860

gagaaagaag tggctgagac ccagcatgga actgttctgg tgcaggttaa atatgaagga     1920

acagacgcac catgcaagat tcccttttcg acccaagatg agaaaggagc aacccagaat     1980

gggagattaa taacagccaa ccccatagtc actgacaaag aaaaaccagt caatattgag     2040

gcagaaccac cctttggtga gagctacatc gtggtaggag caggtgaaaa agctttgaaa     2100

ctaagctggt tcaagaaagg aagcagcata gggaaaatgt ttgaagcaac tgcccgagga     2160

gcacgaagga tggccattct gggagacacc gcatgggact tcggttctat aggaggagtg     2220

ttcacgtcta tgggaaaact ggtacaccag gtttttggaa ctgcatatgg agttttgttt     2280

agcggagttt cttggaccat gaaaatagga atagggattc tgctgacatg gctaggatta     2340

aattcaagga acacgtccct ttcgatgatg tgcatcgcag ccgccattgt gacactgtat     2400

ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa caaagaactg     2460

aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag     2520

ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca tgaagaggac     2580

atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca     2640

gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc     2700

aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat     2760

tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt     2820

ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg     2880

gaagttgaag actatggctt tggagtattc accaccaata tatggctaaa attgaaagaa     2940

aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc     3000

gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag     3060

aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc     3120

aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa     3180

cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagctt     3240

gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat     3300

agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc     3360

cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg     3420

gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga     3480

catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa     3540

atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg     3600

acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc     3660

gccactatga cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc     3720

aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc caaggaattg     3780

atgatgacta ctataggaat tgtactcctc tcccagagca ccctaccaga gaccattctt     3840

gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa     3900

aagtatcaat tggcagtgac tatcatggct atcttgtgcg tcccaaacgc agtgatatta     3960

caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgttc     4020

ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc     4080

aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca     4140

ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa     4200

aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt gtgctacgtg     4260

ctcactggac gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac     4320

caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc     4380

atgtcgataa aaaatgaaga ggaagatcaa acactgacca tactcattag aacaggattg     4440

ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg     4500

tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc cccacccatg     4560

ggaaaggctg aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat     4620

tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca     4680

cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag     4740

aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa     4800

gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca aacgaaacct     4860

ggtcttttca aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga     4920

acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt     4980

gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa     5040

gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc     5100

cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga agctataaaa     5160

cggggtttga gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa     5220

gcccttagag gacttccaat aagataccag accccagcca tcagagctgt gcacaccggg     5280

cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt     5340

agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga cccagcaagt     5400

atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc tgggattttt     5460

atgacagcca ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata     5520

gatgaagaaa gagaaatccc tgaacgctcg tggaattccg gacatgaatg ggtcacggat     5580

tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct     5640

tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag     5700

tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat ttcagaaatg     5760

ggtgccaatt tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata     5820

ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt     5880

gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata     5940

tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg     6000

ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga accagagcgt     6060

gaaaaggtgg atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt     6120

gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa     6180

ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta     6240

gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc     6300

agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt taaggaattt     6360

gcagccggaa gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc     6420

ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag     6480

gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg     6540

cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgca     6600

aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggctag catcctccta     6660

tggtacgcac aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc     6720

atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc     6780

tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc     6840

ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc     6900

aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc cgtggccaca     6960

acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta     7020

acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca     7080

aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata     7140

actctcatag cagctctttt cttattggta gcacattatg ccatcatagg gccaggactc     7200

caagcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca     7260

actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc gaagtttgaa     7320

aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg     7380

actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc cacattgtgg     7440

gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt     7500

agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac     7560

acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg     7620

aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat     7680

agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc tgtgtcgcga     7740

ggctcagcaa aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta     7800

gtggacctcg gttgtggcag aggaggctgg tcatactatt gtggaggact aaagaatgta     7860

agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca     7920

acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca     7980

gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc cacagtggaa     8040

gcaggacgaa cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa     8100

ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta     8160

caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag     8220

atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg     8280

atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc ggatgttgac     8340

ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt     8400

gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac     8460

cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca     8520

tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg     8580

gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt ttttaaagag     8640

aaagtggaca cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca     8700

gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa     8760

gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac     8820

aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag     8880

gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa     8940

agagagaaga agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg     9000

tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg     9060

ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac     9120

attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga     9180

tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac aaaccacatg     9240

gaaggagaac acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg     9300

gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac     9360

caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc     9420

caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc     9480

acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga     9540

atggccatca gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct     9600

ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca     9660

agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc     9720

atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact gattggcaga     9780

gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt ggggaagtct     9840

tacgcccaaa tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat     9900

gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgaacaac ctggtccata     9960

catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg    10020

attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca    10080

tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac aagcagggcc    10140

acctgggcaa agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa    10200

gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga    10260

gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc    10320

catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca    10380

ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg    10440

tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc    10500

ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga    10560

agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag    10620

catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca    10680

gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct                      10723


<210>  2
<211>  3464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 1, BVS

<400>  2

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile Val 
        115                 120                 125             


Ser Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala Gly 
    130                 135                 140                 


Val Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys Glu 
145                 150                 155                 160 


Asp Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Ala Glu Pro Asp 
                165                 170                 175     


Asp Val Asp Cys Trp Cys Asn Ala Thr Asp Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Ser Gln Thr Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Ala Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp 
225                 230                 235                 240 


Ala Leu Arg His Pro Gly Phe Thr Val Ile Ala Leu Phe Leu Ala His 
                245                 250                 255     


Ala Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu Leu 
            260                 265                 270         


Met Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 
    290                 295                 300                 


Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Ala 
        355                 360                 365             


Asn Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys 
385                 390                 395                 400 


Cys Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys 
                405                 410                 415     


Tyr Ser Val Ile Val Thr Val His Thr Gly Asp Gln His Gln Val Gly 
            420                 425                 430         


Asn Glu Thr Thr Glu His Gly Thr Thr Ala Thr Ile Thr Pro Gln Ala 
        435                 440                 445             


Pro Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Thr Leu Thr Leu Asp 
    450                 455                 460                 


Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Thr 
465                 470                 475                 480 


Met Lys Glu Arg Ser Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp Asn 
            500                 505                 510         


Arg Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys Gln 
        515                 520                 525             


Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu 
    530                 535                 540                 


Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr Thr Ile Phe Ala 
545                 550                 555                 560 


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Thr Leu Lys Gly 
                565                 570                 575     


Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu Val 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly 
        595                 600                 605             


Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys Gly 
    610                 615                 620                 


Ala Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp 
625                 630                 635                 640 


Lys Glu Lys Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser 
                645                 650                 655     


Tyr Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp Phe 
            660                 665                 670         


Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly 
        675                 680                 685             


Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Ile Gly Gly Val Phe Thr Ser Met Gly Lys Leu Val His Gln Val Phe 
705                 710                 715                 720 


Gly Thr Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys 
                725                 730                 735     


Ile Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Asn 
            740                 745                 750         


Thr Ser Leu Ser Met Met Cys Ile Ala Ala Ala Ile Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 
    770                 775                 780                 


Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 
                805                 810                 815     


Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile 
            820                 825                 830         


Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 
        835                 840                 845             


Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 
    850                 855                 860                 


Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 
865                 870                 875                 880 


Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 
                885                 890                 895     


Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 
            900                 905                 910         


Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Asn Cys His Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Asn Leu Ala 
    1010                 1015                 1020             


Gly Pro  Val Ser Gln His Asn  Tyr Arg Pro Gly Tyr  His Thr Gln 
    1025                 1030                 1035             


Ile Thr  Gly Pro Trp His Leu  Gly Lys Leu Glu Met  Asp Phe Asp 
    1040                 1045                 1050             


Phe Cys  Asp Gly Thr Thr Val  Val Val Thr Glu Asp  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Ala Ser Gly  Lys Leu Ile 
    1070                 1075                 1080             


Thr Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr 
    1085                 1090                 1095             


Arg Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Leu 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Asn Ser Leu Val  Thr Ala Gly 
    1115                 1120                 1125             


His Gly  Gln Val Asp Asn Phe  Ser Leu Gly Val Leu  Gly Met Ala 
    1130                 1135                 1140             


Leu Phe  Leu Glu Glu Met Leu  Arg Thr Arg Val Gly  Thr Lys His 
    1145                 1150                 1155             


Ala Ile  Leu Leu Val Ala Val  Ser Phe Val Thr Leu  Ile Thr Gly 
    1160                 1165                 1170             


Asn Met  Ser Phe Arg Asp Leu  Gly Arg Val Met Val  Met Val Gly 
    1175                 1180                 1185             


Ala Thr  Met Thr Asp Asp Ile  Gly Met Gly Val Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Leu  Ala Ala Phe Lys Val  Arg Pro Thr Phe Ala  Ala Gly Leu 
    1205                 1210                 1215             


Leu Leu  Arg Lys Leu Thr Ser  Lys Glu Leu Met Met  Thr Thr Ile 
    1220                 1225                 1230             


Gly Ile  Val Leu Leu Ser Gln  Ser Thr Leu Pro Glu  Thr Ile Leu 
    1235                 1240                 1245             


Glu Leu  Thr Asp Ala Leu Ala  Leu Gly Met Met Val  Leu Lys Met 
    1250                 1255                 1260             


Val Arg  Asn Met Glu Lys Tyr  Gln Leu Ala Val Thr  Ile Met Ala 
    1265                 1270                 1275             


Ile Leu  Cys Val Pro Asn Ala  Val Ile Leu Gln Asn  Ala Trp Lys 
    1280                 1285                 1290             


Val Ser  Cys Thr Ile Leu Ala  Val Val Ser Val Ser  Pro Leu Phe 
    1295                 1300                 1305             


Leu Thr  Ser Ser Gln Gln Lys  Thr Asp Trp Ile Pro  Leu Ala Leu 
    1310                 1315                 1320             


Thr Ile  Lys Gly Leu Asn Pro  Thr Ala Ile Phe Leu  Thr Thr Leu 
    1325                 1330                 1335             


Ser Arg  Thr Ser Lys Lys Arg  Ser Trp Pro Leu Asn  Glu Ala Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Met Val Ser  Ile Leu Ala Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Ile Pro Met Thr Gly  Pro Leu Val Ala Gly  Gly Leu Leu 
    1370                 1375                 1380             


Thr Val  Cys Tyr Val Leu Thr  Gly Arg Ser Ala Asp  Leu Glu Leu 
    1385                 1390                 1395             


Glu Arg  Ala Ala Asp Val Lys  Trp Glu Asp Gln Ala  Glu Ile Ser 
    1400                 1405                 1410             


Gly Ser  Ser Pro Ile Leu Ser  Ile Thr Ile Ser Glu  Asp Gly Ser 
    1415                 1420                 1425             


Met Ser  Ile Lys Asn Glu Glu  Glu Asp Gln Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Ile Arg  Thr Gly Leu Leu Val  Ile Ser Gly Leu Phe  Pro Val Ser 
    1445                 1450                 1455             


Ile Pro  Ile Thr Ala Ala Ala  Trp Tyr Leu Trp Glu  Val Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ala Gly Val Leu Trp  Asp Val Pro Ser Pro  Pro Pro Met 
    1475                 1480                 1485             


Gly Lys  Ala Glu Leu Glu Asp  Gly Ala Tyr Arg Ile  Lys Gln Lys 
    1490                 1495                 1500             


Gly Ile  Leu Gly Tyr Ser Gln  Ile Gly Ala Gly Val  Tyr Lys Glu 
    1505                 1510                 1515             


Gly Thr  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met His  Lys Gly Lys Arg Ile  Glu Pro Ser Trp Ala  Asp Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Lys Leu  Glu Gly Glu 
    1550                 1555                 1560             


Trp Lys  Glu Gly Glu Glu Val  Gln Val Leu Ala Leu  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Arg Ala Val Gln  Thr Lys Pro Gly Leu  Phe Lys Thr 
    1580                 1585                 1590             


Asn Ala  Gly Thr Ile Gly Ala  Val Ser Leu Asp Phe  Ser Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Ile  Asp Lys Lys Gly Lys  Val Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Arg Ser Gly Ala  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Thr Glu Lys  Ser Ile Glu Asp Asn  Pro Glu Ile 
    1640                 1645                 1650             


Glu Asp  Asp Ile Phe Arg Lys  Arg Arg Leu Thr Ile  Met Asp Leu 
    1655                 1660                 1665             


His Pro  Gly Ala Gly Lys Thr  Lys Arg Tyr Leu Pro  Ala Ile Val 
    1670                 1675                 1680             


Arg Glu  Ala Ile Lys Arg Gly  Leu Arg Thr Leu Ile  Leu Ala Pro 
    1685                 1690                 1695             


Thr Arg  Val Val Ala Ala Glu  Met Glu Glu Ala Leu  Arg Gly Leu 
    1700                 1705                 1710             


Pro Ile  Arg Tyr Gln Thr Pro  Ala Ile Arg Ala Val  His Thr Gly 
    1715                 1720                 1725             


Arg Glu  Ile Val Asp Leu Met  Cys His Ala Thr Phe  Thr Met Arg 
    1730                 1735                 1740             


Leu Leu  Ser Pro Val Arg Val  Pro Asn Tyr Asn Leu  Ile Ile Met 
    1745                 1750                 1755             


Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly 
    1760                 1765                 1770             


Tyr Ile  Ser Thr Arg Val Glu  Met Gly Glu Ala Ala  Gly Ile Phe 
    1775                 1780                 1785             


Met Thr  Ala Thr Pro Pro Gly  Ser Arg Asp Pro Phe  Pro Gln Ser 
    1790                 1795                 1800             


Asn Ala  Pro Ile Ile Asp Glu  Glu Arg Glu Ile Pro  Glu Arg Ser 
    1805                 1810                 1815             


Trp Asn  Ser Gly His Glu Trp  Val Thr Asp Phe Lys  Gly Lys Thr 
    1820                 1825                 1830             


Val Trp  Phe Val Pro Ser Ile  Lys Ala Gly Asn Asp  Ile Ala Ala 
    1835                 1840                 1845             


Cys Leu  Arg Lys Asn Gly Lys  Lys Val Ile Gln Leu  Ser Arg Lys 
    1850                 1855                 1860             


Thr Phe  Asp Ser Glu Tyr Val  Lys Thr Arg Thr Asn  Asp Trp Asp 
    1865                 1870                 1875             


Phe Val  Val Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys 
    1880                 1885                 1890             


Ala Glu  Arg Val Ile Asp Pro  Arg Arg Cys Met Lys  Pro Val Ile 
    1895                 1900                 1905             


Leu Thr  Asp Gly Glu Glu Arg  Val Ile Leu Ala Gly  Pro Met Pro 
    1910                 1915                 1920             


Val Thr  His Ser Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg 
    1925                 1930                 1935             


Asn Pro  Lys Asn Glu Asn Asp  Gln Tyr Ile Tyr Met  Gly Glu Pro 
    1940                 1945                 1950             


Leu Glu  Asn Asp Glu Asp Cys  Ala His Trp Lys Glu  Ala Lys Met 
    1955                 1960                 1965             


Leu Leu  Asp Asn Ile Asn Thr  Pro Glu Gly Ile Ile  Pro Ser Met 
    1970                 1975                 1980             


Phe Glu  Pro Glu Arg Glu Lys  Val Asp Ala Ile Asp  Gly Glu Tyr 
    1985                 1990                 1995             


Arg Leu  Arg Gly Glu Ala Arg  Lys Thr Phe Val Asp  Leu Met Arg 
    2000                 2005                 2010             


Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr Arg Val  Ala Ala Glu 
    2015                 2020                 2025             


Gly Ile  Asn Tyr Ala Asp Arg  Arg Trp Cys Phe Asp  Gly Val Lys 
    2030                 2035                 2040             


Asn Asn  Gln Ile Leu Glu Glu  Asn Val Glu Val Glu  Ile Trp Thr 
    2045                 2050                 2055             


Lys Glu  Gly Glu Arg Lys Lys  Leu Lys Pro Arg Trp  Leu Asp Ala 
    2060                 2065                 2070             


Arg Ile  Tyr Ser Asp Pro Leu  Ala Leu Lys Glu Phe  Lys Glu Phe 
    2075                 2080                 2085             


Ala Ala  Gly Arg Lys Ser Leu  Thr Leu Asn Leu Ile  Thr Glu Met 
    2090                 2095                 2100             


Gly Arg  Leu Pro Thr Phe Met  Thr Gln Lys Ala Arg  Asp Ala Leu 
    2105                 2110                 2115             


Asp Asn  Leu Ala Val Leu His  Thr Ala Glu Ala Gly  Gly Arg Ala 
    2120                 2125                 2130             


Tyr Asn  His Ala Leu Ser Glu  Leu Pro Glu Thr Leu  Glu Thr Leu 
    2135                 2140                 2145             


Leu Leu  Leu Thr Leu Leu Ala  Thr Val Thr Gly Gly  Ile Phe Leu 
    2150                 2155                 2160             


Phe Leu  Met Ser Ala Arg Gly  Ile Gly Lys Met Thr  Leu Gly Met 
    2165                 2170                 2175             


Cys Cys  Ile Ile Thr Ala Ser  Ile Leu Leu Trp Tyr  Ala Gln Ile 
    2180                 2185                 2190             


Gln Pro  His Trp Ile Ala Ala  Ser Ile Ile Leu Glu  Phe Phe Leu 
    2195                 2200                 2205             


Ile Val  Leu Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Thr Pro Gln 
    2210                 2215                 2220             


Asp Asn  Gln Leu Thr Tyr Val  Val Ile Ala Ile Leu  Thr Val Val 
    2225                 2230                 2235             


Ala Ala  Thr Met Ala Asn Glu  Met Gly Phe Leu Glu  Lys Thr Lys 
    2240                 2245                 2250             


Lys Asp  Leu Gly Leu Gly Ser  Ile Ala Thr Gln Gln  Pro Glu Ser 
    2255                 2260                 2265             


Asn Ile  Leu Asp Ile Asp Leu  Arg Pro Ala Ser Ala  Trp Thr Leu 
    2270                 2275                 2280             


Tyr Ala  Val Ala Thr Thr Phe  Val Thr Pro Met Leu  Arg His Ser 
    2285                 2290                 2295             


Ile Glu  Asn Ser Ser Val Asn  Val Ser Leu Thr Ala  Ile Ala Asn 
    2300                 2305                 2310             


Gln Ala  Thr Val Leu Met Gly  Leu Gly Lys Gly Trp  Pro Leu Ser 
    2315                 2320                 2325             


Lys Met  Asp Ile Gly Val Pro  Leu Leu Ala Ile Gly  Cys Tyr Ser 
    2330                 2335                 2340             


Gln Val  Asn Pro Ile Thr Leu  Ile Ala Ala Leu Phe  Leu Leu Val 
    2345                 2350                 2355             


Ala His  Tyr Ala Ile Ile Gly  Pro Gly Leu Gln Ala  Lys Ala Thr 
    2360                 2365                 2370             


Arg Glu  Ala Gln Lys Arg Ala  Ala Ala Gly Ile Met  Lys Asn Pro 
    2375                 2380                 2385             


Thr Val  Asp Gly Ile Thr Val  Ile Asp Leu Asp Pro  Ile Pro Tyr 
    2390                 2395                 2400             


Asp Pro  Lys Phe Glu Lys Gln  Leu Gly Gln Val Met  Leu Leu Val 
    2405                 2410                 2415             


Leu Cys  Val Thr Gln Val Leu  Met Met Arg Thr Thr  Trp Ala Leu 
    2420                 2425                 2430             


Cys Glu  Ala Leu Thr Leu Ala  Thr Gly Pro Ile Ser  Thr Leu Trp 
    2435                 2440                 2445             


Glu Gly  Asn Pro Gly Arg Phe  Trp Asn Thr Thr Ile  Ala Val Ser 
    2450                 2455                 2460             


Met Ala  Asn Ile Phe Arg Gly  Ser Tyr Leu Ala Gly  Ala Gly Leu 
    2465                 2470                 2475             


Leu Phe  Ser Ile Met Lys Asn  Thr Thr Asn Thr Arg  Arg Gly Thr 
    2480                 2485                 2490             


Gly Asn  Ile Gly Glu Thr Leu  Gly Glu Lys Trp Lys  Ser Arg Leu 
    2495                 2500                 2505             


Asn Ala  Leu Gly Lys Ser Glu  Phe Gln Ile Tyr Lys  Lys Ser Gly 
    2510                 2515                 2520             


Ile Gln  Glu Val Asp Arg Thr  Leu Ala Lys Glu Gly  Ile Lys Arg 
    2525                 2530                 2535             


Gly Glu  Thr Asp His His Ala  Val Ser Arg Gly Ser  Ala Lys Leu 
    2540                 2545                 2550             


Arg Trp  Phe Val Glu Arg Asn  Met Val Thr Pro Glu  Gly Lys Val 
    2555                 2560                 2565             


Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp Ser Tyr  Tyr Cys Gly 
    2570                 2575                 2580             


Gly Leu  Lys Asn Val Arg Glu  Val Lys Gly Leu Thr  Lys Gly Gly 
    2585                 2590                 2595             


Pro Gly  His Glu Glu Pro Ile  Pro Met Ser Thr Tyr  Gly Trp Asn 
    2600                 2605                 2610             


Leu Val  Arg Leu Gln Ser Gly  Val Asp Val Phe Phe  Ile Pro Pro 
    2615                 2620                 2625             


Glu Lys  Cys Asp Thr Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Pro 
    2630                 2635                 2640             


Asn Pro  Thr Val Glu Ala Gly  Arg Thr Leu Arg Val  Leu Asn Leu 
    2645                 2650                 2655             


Val Glu  Asn Trp Leu Asn Asn  Asn Thr Gln Phe Cys  Ile Lys Val 
    2660                 2665                 2670             


Leu Asn  Pro Tyr Met Pro Ser  Val Ile Glu Lys Met  Glu Ala Leu 
    2675                 2680                 2685             


Gln Arg  Lys Tyr Gly Gly Ala  Leu Val Arg Asn Pro  Leu Ser Arg 
    2690                 2695                 2700             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Asn Ala  Ser Gly Asn 
    2705                 2710                 2715             


Ile Val  Ser Ser Val Asn Met  Ile Ser Arg Met Leu  Ile Asn Arg 
    2720                 2725                 2730             


Phe Thr  Met Arg Tyr Lys Lys  Ala Thr Tyr Glu Pro  Asp Val Asp 
    2735                 2740                 2745             


Leu Gly  Ser Gly Thr Arg Asn  Ile Gly Ile Glu Ser  Glu Ile Pro 
    2750                 2755                 2760             


Asn Leu  Asp Ile Ile Gly Lys  Arg Ile Glu Lys Ile  Lys Gln Glu 
    2765                 2770                 2775             


His Glu  Thr Ser Trp His Tyr  Asp Gln Asp His Pro  Tyr Lys Thr 
    2780                 2785                 2790             


Trp Ala  Tyr His Gly Ser Tyr  Glu Thr Lys Gln Thr  Gly Ser Ala 
    2795                 2800                 2805             


Ser Ser  Met Val Asn Gly Val  Val Arg Leu Leu Thr  Lys Pro Trp 
    2810                 2815                 2820             


Asp Val  Val Pro Met Val Thr  Gln Met Ala Met Thr  Asp Thr Thr 
    2825                 2830                 2835             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2840                 2845                 2850             


Thr Gln  Glu Pro Lys Glu Gly  Thr Lys Lys Leu Met  Lys Ile Thr 
    2855                 2860                 2865             


Ala Glu  Trp Leu Trp Lys Glu  Leu Gly Lys Lys Lys  Thr Pro Arg 
    2870                 2875                 2880             


Met Cys  Thr Arg Glu Glu Phe  Thr Arg Lys Val Arg  Ser Asn Ala 
    2885                 2890                 2895             


Ala Leu  Gly Ala Ile Phe Thr  Asp Glu Asn Lys Trp  Lys Ser Ala 
    2900                 2905                 2910             


Arg Glu  Ala Val Glu Asp Ser  Arg Phe Trp Glu Leu  Val Asp Lys 
    2915                 2920                 2925             


Glu Arg  Asn Leu His Leu Glu  Gly Lys Cys Glu Thr  Cys Val Tyr 
    2930                 2935                 2940             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Leu Gly Glu  Phe Gly Lys 
    2945                 2950                 2955             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2960                 2965                 2970             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    2975                 2980                 2985             


Phe Ser  Arg Glu Asn Ser Leu  Ser Gly Val Glu Gly  Glu Gly Leu 
    2990                 2995                 3000             


His Lys  Leu Gly Tyr Ile Leu  Arg Asp Val Ser Lys  Lys Glu Gly 
    3005                 3010                 3015             


Gly Ala  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3020                 3025                 3030             


Thr Leu  Glu Asp Leu Lys Asn  Glu Glu Met Val Thr  Asn His Met 
    3035                 3040                 3045             


Glu Gly  Glu His Lys Lys Leu  Ala Glu Ala Ile Phe  Lys Leu Thr 
    3050                 3055                 3060             


Tyr Gln  Asn Lys Val Val Arg  Val Gln Arg Pro Thr  Pro Arg Gly 
    3065                 3070                 3075             


Thr Val  Met Asp Ile Ile Ser  Arg Arg Asp Gln Arg  Gly Ser Gly 
    3080                 3085                 3090             


Gln Val  Gly Thr Tyr Gly Leu  Asn Thr Phe Thr Asn  Met Glu Ala 
    3095                 3100                 3105             


Gln Leu  Ile Arg Gln Met Glu  Gly Glu Gly Val Phe  Lys Ser Ile 
    3110                 3115                 3120             


Gln His  Leu Thr Ile Thr Glu  Glu Ile Ala Val Gln  Asn Trp Leu 
    3125                 3130                 3135             


Ala Arg  Val Gly Arg Glu Arg  Leu Ser Arg Met Ala  Ile Ser Gly 
    3140                 3145                 3150             


Asp Asp  Cys Val Val Lys Pro  Leu Asp Asp Arg Phe  Ala Ser Ala 
    3155                 3160                 3165             


Leu Thr  Ala Leu Asn Asp Met  Gly Lys Ile Arg Lys  Asp Ile Gln 
    3170                 3175                 3180             


Gln Trp  Glu Pro Ser Arg Gly  Trp Asn Asp Trp Thr  Gln Val Pro 
    3185                 3190                 3195             


Phe Cys  Ser His His Phe His  Glu Leu Ile Met Lys  Asp Gly Arg 
    3200                 3205                 3210             


Val Leu  Val Val Pro Cys Arg  Asn Gln Asp Glu Leu  Ile Gly Arg 
    3215                 3220                 3225             


Ala Arg  Ile Ser Gln Gly Ala  Gly Trp Ser Leu Arg  Glu Thr Ala 
    3230                 3235                 3240             


Cys Leu  Gly Lys Ser Tyr Ala  Gln Met Trp Ser Leu  Met Tyr Phe 
    3245                 3250                 3255             


His Arg  Arg Asp Leu Arg Leu  Ala Ala Asn Ala Ile  Cys Ser Ala 
    3260                 3265                 3270             


Val Pro  Ser His Trp Val Pro  Thr Ser Arg Thr Thr  Trp Ser Ile 
    3275                 3280                 3285             


His Ala  Lys His Glu Trp Met  Thr Thr Glu Asp Met  Leu Thr Val 
    3290                 3295                 3300             


Trp Asn  Arg Val Trp Ile Gln  Glu Asn Pro Trp Met  Glu Asp Lys 
    3305                 3310                 3315             


Thr Pro  Val Glu Ser Trp Glu  Glu Ile Pro Tyr Leu  Gly Lys Arg 
    3320                 3325                 3330             


Glu Asp  Gln Trp Cys Gly Ser  Leu Ile Gly Leu Thr  Ser Arg Ala 
    3335                 3340                 3345             


Thr Trp  Ala Lys Asn Ile Gln  Ala Ala Ile Asn Gln  Val Arg Ser 
    3350                 3355                 3360             


Leu Ile  Gly Asn Glu Glu Tyr  Thr Asp Tyr Met Pro  Ser Met Lys 
    3365                 3370                 3375             


Arg Phe  Arg Arg Glu Glu Glu  Glu Ala Gly Val Leu  Trp Lys Ala 
    3380                 3385                 3390             


Lys Leu  Thr Asn Lys Ala Arg  Ser Gln Val Gly Leu  Ser His Ser 
    3395                 3400                 3405             


Thr Glu  Lys Thr Met Leu Pro  Val Ser Pro Val Gln  Gly Arg Lys 
    3410                 3415                 3420             


Lys Ser  Gly His His Lys Cys  His Ser Leu Ser Lys  Leu Cys Ser 
    3425                 3430                 3435             


Leu Leu  His Leu Arg Arg Cys  Lys Lys Ser Gly Arg  Pro Gln Thr 
    3440                 3445                 3450             


Met Glu  Ala Val Arg Met Ala  Trp Thr Ser Gly 
    3455                 3460                 


<210>  3
<211>  3391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 1, MVS

<400>  3

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile Val 
        115                 120                 125             


Ser Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala Gly 
    130                 135                 140                 


Val Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys Glu 
145                 150                 155                 160 


Asp Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Ala Glu Pro Asp 
                165                 170                 175     


Asp Val Asp Cys Trp Cys Asn Ala Thr Asp Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Ser Gln Thr Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Ala Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp 
225                 230                 235                 240 


Ala Leu Arg His Pro Gly Phe Thr Val Ile Ala Leu Phe Leu Ala His 
                245                 250                 255     


Ala Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu Leu 
            260                 265                 270         


Met Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 
    290                 295                 300                 


Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Ala 
        355                 360                 365             


Asn Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys 
385                 390                 395                 400 


Cys Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys 
                405                 410                 415     


Tyr Ser Val Ile Val Thr Val His Thr Gly Asp Gln His Gln Val Gly 
            420                 425                 430         


Asn Glu Thr Thr Glu His Gly Thr Thr Ala Thr Ile Thr Pro Gln Ala 
        435                 440                 445             


Pro Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Thr Leu Thr Leu Asp 
    450                 455                 460                 


Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Thr 
465                 470                 475                 480 


Met Lys Glu Arg Ser Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp Asn 
            500                 505                 510         


Arg Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys Gln 
        515                 520                 525             


Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu 
    530                 535                 540                 


Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr Thr Ile Phe Ala 
545                 550                 555                 560 


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Thr Leu Lys Gly 
                565                 570                 575     


Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu Val 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly 
        595                 600                 605             


Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys Gly 
    610                 615                 620                 


Ala Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp 
625                 630                 635                 640 


Lys Glu Lys Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser 
                645                 650                 655     


Tyr Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp Phe 
            660                 665                 670         


Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly 
        675                 680                 685             


Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Ile Gly Gly Val Phe Thr Ser Met Gly Lys Leu Val His Gln Val Phe 
705                 710                 715                 720 


Gly Thr Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys 
                725                 730                 735     


Ile Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Asn 
            740                 745                 750         


Thr Ser Leu Ser Met Met Cys Ile Ala Ala Gly Ile Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 
    770                 775                 780                 


Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 
                805                 810                 815     


Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile 
            820                 825                 830         


Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 
        835                 840                 845             


Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 
    850                 855                 860                 


Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 
865                 870                 875                 880 


Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 
                885                 890                 895     


Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 
            900                 905                 910         


Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Asn Cys His Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Asn Leu Ala 
    1010                 1015                 1020             


Gly Pro  Val Ser Gln His Asn  Tyr Arg Pro Gly Tyr  His Thr Gln 
    1025                 1030                 1035             


Ile Thr  Gly Pro Trp His Leu  Gly Lys Leu Glu Met  Asp Phe Asp 
    1040                 1045                 1050             


Phe Cys  Asp Gly Thr Thr Val  Val Val Thr Glu Asp  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Ala Ser Gly  Lys Leu Ile 
    1070                 1075                 1080             


Thr Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr 
    1085                 1090                 1095             


Arg Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Leu 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Asn Ser Leu Val  Thr Ala Gly 
    1115                 1120                 1125             


His Gly  Gln Val Asp Asn Phe  Ser Leu Gly Val Leu  Gly Met Ala 
    1130                 1135                 1140             


Leu Phe  Leu Glu Glu Met Leu  Arg Thr Arg Val Gly  Thr Lys His 
    1145                 1150                 1155             


Ala Ile  Leu Leu Val Ala Val  Ser Phe Val Thr Leu  Ile Thr Gly 
    1160                 1165                 1170             


Asn Met  Ser Phe Arg Asp Leu  Gly Arg Val Met Val  Met Val Gly 
    1175                 1180                 1185             


Ala Thr  Met Thr Asp Asp Ile  Gly Met Gly Val Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Leu  Ala Ala Phe Lys Val  Arg Pro Thr Phe Ala  Ala Gly Leu 
    1205                 1210                 1215             


Leu Leu  Arg Lys Leu Thr Ser  Lys Glu Leu Met Met  Thr Thr Ile 
    1220                 1225                 1230             


Gly Ile  Val Leu Leu Ser Gln  Ser Thr Leu Pro Glu  Thr Ile Leu 
    1235                 1240                 1245             


Glu Leu  Thr Asp Ala Leu Ala  Leu Gly Met Met Val  Leu Lys Met 
    1250                 1255                 1260             


Val Arg  Asn Met Glu Lys Tyr  Gln Leu Ala Val Thr  Ile Met Ala 
    1265                 1270                 1275             


Ile Leu  Cys Val Pro Asn Ala  Val Ile Leu Gln Asn  Ala Trp Lys 
    1280                 1285                 1290             


Val Ser  Cys Thr Ile Leu Ala  Val Val Ser Val Ser  Pro Leu Phe 
    1295                 1300                 1305             


Leu Thr  Ser Ser Gln Gln Lys  Thr Asp Trp Ile Pro  Leu Ala Leu 
    1310                 1315                 1320             


Thr Ile  Lys Gly Leu Asn Pro  Thr Ala Ile Phe Leu  Thr Thr Leu 
    1325                 1330                 1335             


Ser Arg  Thr Ser Lys Lys Arg  Ser Trp Pro Leu Asn  Glu Ala Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Met Val Ser  Ile Leu Ala Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Ile Pro Met Thr Gly  Pro Leu Val Ala Gly  Gly Leu Leu 
    1370                 1375                 1380             


Thr Val  Cys Tyr Val Leu Thr  Gly Arg Ser Ala Asp  Leu Glu Leu 
    1385                 1390                 1395             


Glu Arg  Ala Ala Asp Val Lys  Trp Glu Asp Gln Ala  Glu Ile Ser 
    1400                 1405                 1410             


Gly Ser  Ser Pro Ile Leu Ser  Ile Thr Ile Ser Glu  Asp Gly Ser 
    1415                 1420                 1425             


Met Ser  Ile Lys Asn Glu Glu  Glu Asp Gln Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Ile Arg  Thr Gly Leu Leu Val  Ile Ser Gly Leu Phe  Pro Val Ser 
    1445                 1450                 1455             


Ile Pro  Ile Thr Ala Ala Ala  Trp Tyr Leu Trp Glu  Val Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ala Gly Val Leu Trp  Asp Val Pro Ser Pro  Pro Pro Met 
    1475                 1480                 1485             


Gly Lys  Ala Glu Leu Glu Asp  Gly Ala Tyr Arg Ile  Lys Gln Lys 
    1490                 1495                 1500             


Gly Ile  Leu Gly Tyr Ser Gln  Ile Gly Ala Gly Val  Tyr Lys Glu 
    1505                 1510                 1515             


Gly Thr  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met His  Lys Gly Lys Arg Ile  Glu Pro Ser Trp Ala  Asp Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Lys Leu  Glu Gly Glu 
    1550                 1555                 1560             


Trp Lys  Glu Gly Glu Glu Val  Gln Val Leu Ala Leu  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Arg Ala Val Gln  Thr Lys Pro Gly Leu  Phe Lys Thr 
    1580                 1585                 1590             


Asn Ala  Gly Thr Ile Gly Ala  Val Ser Leu Asp Phe  Ser Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Ile  Asp Lys Lys Gly Lys  Val Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Arg Ser Gly Ala  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Thr Glu Lys  Ser Ile Glu Asp Asn  Pro Glu Ile 
    1640                 1645                 1650             


Glu Asp  Asp Ile Phe Arg Lys  Arg Arg Leu Thr Ile  Met Asp Leu 
    1655                 1660                 1665             


His Pro  Gly Ala Gly Lys Thr  Lys Arg Tyr Leu Pro  Ala Ile Val 
    1670                 1675                 1680             


Arg Glu  Ala Ile Lys Arg Gly  Leu Arg Thr Leu Ile  Leu Ala Pro 
    1685                 1690                 1695             


Thr Arg  Val Val Ala Ala Glu  Met Glu Glu Ala Leu  Arg Gly Leu 
    1700                 1705                 1710             


Pro Ile  Arg Tyr Gln Thr Pro  Ala Ile Arg Ala Val  His Thr Gly 
    1715                 1720                 1725             


Arg Glu  Ile Val Asp Leu Met  Cys His Ala Thr Phe  Thr Met Arg 
    1730                 1735                 1740             


Leu Leu  Ser Pro Val Arg Val  Pro Asn Tyr Asn Leu  Ile Ile Met 
    1745                 1750                 1755             


Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly 
    1760                 1765                 1770             


Tyr Ile  Ser Thr Arg Val Glu  Met Gly Glu Ala Ala  Gly Ile Phe 
    1775                 1780                 1785             


Met Thr  Ala Thr Pro Pro Gly  Ser Arg Asp Pro Phe  Pro Gln Ser 
    1790                 1795                 1800             


Asn Ala  Pro Ile Ile Asp Glu  Glu Arg Glu Ile Pro  Glu Arg Ser 
    1805                 1810                 1815             


Trp Asn  Ser Gly His Glu Trp  Val Thr Asp Phe Lys  Gly Lys Thr 
    1820                 1825                 1830             


Val Trp  Phe Val Pro Ser Ile  Lys Ala Gly Asn Asp  Ile Ala Ala 
    1835                 1840                 1845             


Cys Leu  Arg Lys Asn Gly Lys  Lys Val Ile Gln Leu  Ser Arg Lys 
    1850                 1855                 1860             


Thr Phe  Asp Ser Glu Tyr Val  Lys Thr Arg Thr Asn  Asp Trp Asp 
    1865                 1870                 1875             


Phe Val  Val Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys 
    1880                 1885                 1890             


Ala Glu  Arg Val Ile Asp Pro  Arg Arg Cys Met Lys  Pro Val Ile 
    1895                 1900                 1905             


Leu Thr  Asp Gly Glu Glu Arg  Val Ile Leu Ala Gly  Pro Met Pro 
    1910                 1915                 1920             


Val Thr  His Ser Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg 
    1925                 1930                 1935             


Asn Pro  Lys Asn Glu Asn Asp  Gln Tyr Ile Tyr Met  Gly Glu Pro 
    1940                 1945                 1950             


Leu Glu  Asn Asp Glu Asp Cys  Ala His Trp Lys Glu  Ala Lys Met 
    1955                 1960                 1965             


Leu Leu  Asp Asn Ile Asn Thr  Pro Glu Gly Ile Ile  Pro Ser Met 
    1970                 1975                 1980             


Phe Glu  Pro Glu Arg Glu Lys  Val Asp Ala Ile Asp  Gly Glu Tyr 
    1985                 1990                 1995             


Arg Leu  Arg Gly Glu Ala Arg  Lys Thr Phe Val Asp  Leu Met Arg 
    2000                 2005                 2010             


Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr Arg Val  Ala Ala Glu 
    2015                 2020                 2025             


Gly Ile  Asn Tyr Ala Asp Arg  Arg Trp Cys Phe Asp  Gly Val Lys 
    2030                 2035                 2040             


Asn Asn  Gln Ile Leu Glu Glu  Asn Val Glu Val Glu  Ile Trp Thr 
    2045                 2050                 2055             


Lys Glu  Gly Glu Arg Lys Lys  Leu Lys Pro Arg Trp  Leu Asp Ala 
    2060                 2065                 2070             


Arg Ile  Tyr Ser Asp Pro Leu  Ala Leu Lys Glu Phe  Lys Glu Phe 
    2075                 2080                 2085             


Ala Ala  Gly Arg Lys Ser Leu  Thr Leu Asn Leu Ile  Thr Glu Met 
    2090                 2095                 2100             


Gly Arg  Leu Pro Thr Phe Met  Thr Gln Lys Ala Arg  Asp Ala Leu 
    2105                 2110                 2115             


Asp Asn  Leu Ala Val Leu His  Thr Ala Glu Ala Gly  Gly Arg Ala 
    2120                 2125                 2130             


Tyr Asn  His Ala Leu Ser Glu  Leu Pro Glu Thr Leu  Glu Thr Leu 
    2135                 2140                 2145             


Leu Leu  Leu Thr Leu Leu Ala  Thr Val Thr Gly Gly  Ile Phe Leu 
    2150                 2155                 2160             


Phe Leu  Met Ser Ala Arg Gly  Ile Gly Lys Met Thr  Leu Gly Met 
    2165                 2170                 2175             


Cys Cys  Ile Ile Thr Ala Ser  Ile Leu Leu Trp Tyr  Ala Gln Ile 
    2180                 2185                 2190             


Gln Pro  His Trp Ile Ala Ala  Ser Ile Ile Leu Glu  Phe Phe Leu 
    2195                 2200                 2205             


Ile Val  Leu Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Thr Pro Gln 
    2210                 2215                 2220             


Asp Asn  Gln Leu Thr Tyr Val  Val Ile Ala Ile Leu  Thr Val Val 
    2225                 2230                 2235             


Ala Ala  Thr Met Ala Asn Glu  Met Gly Phe Leu Glu  Lys Thr Lys 
    2240                 2245                 2250             


Lys Asp  Leu Gly Leu Gly Ser  Ile Ala Thr Gln Gln  Pro Glu Ser 
    2255                 2260                 2265             


Asn Ile  Leu Asp Ile Asp Leu  Arg Pro Ala Ser Ala  Trp Thr Leu 
    2270                 2275                 2280             


Tyr Ala  Val Ala Thr Thr Phe  Val Thr Pro Met Leu  Arg His Ser 
    2285                 2290                 2295             


Ile Glu  Asn Ser Ser Val Asn  Val Ser Leu Thr Ala  Ile Ala Asn 
    2300                 2305                 2310             


Gln Ala  Thr Val Leu Met Gly  Leu Gly Lys Gly Trp  Pro Leu Ser 
    2315                 2320                 2325             


Lys Met  Asp Ile Gly Val Pro  Leu Leu Ala Ile Gly  Cys Tyr Ser 
    2330                 2335                 2340             


Gln Val  Asn Pro Ile Thr Leu  Thr Ala Ala Leu Phe  Leu Leu Val 
    2345                 2350                 2355             


Ala His  Tyr Ala Ile Ile Gly  Pro Gly Leu Gln Ala  Lys Ala Thr 
    2360                 2365                 2370             


Arg Glu  Ala Gln Lys Arg Ala  Ala Ala Gly Ile Met  Lys Asn Pro 
    2375                 2380                 2385             


Thr Val  Asp Gly Ile Thr Val  Ile Asp Leu Asp Pro  Ile Pro Tyr 
    2390                 2395                 2400             


Asp Pro  Lys Phe Glu Lys Gln  Leu Gly Gln Val Met  Leu Leu Val 
    2405                 2410                 2415             


Leu Cys  Val Thr Gln Val Leu  Met Met Arg Thr Thr  Trp Ala Leu 
    2420                 2425                 2430             


Cys Glu  Ala Leu Thr Leu Ala  Thr Gly Pro Ile Ser  Thr Leu Trp 
    2435                 2440                 2445             


Glu Gly  Asn Pro Gly Arg Phe  Trp Asn Thr Thr Ile  Ala Val Ser 
    2450                 2455                 2460             


Met Ala  Asn Ile Phe Arg Gly  Ser Tyr Leu Ala Gly  Ala Gly Leu 
    2465                 2470                 2475             


Leu Phe  Ser Ile Met Lys Asn  Thr Thr Asn Thr Arg  Arg Gly Thr 
    2480                 2485                 2490             


Gly Asn  Ile Gly Glu Thr Leu  Gly Glu Lys Trp Lys  Ser Arg Leu 
    2495                 2500                 2505             


Asn Ala  Leu Gly Lys Ser Glu  Phe Gln Ile Tyr Lys  Lys Ser Gly 
    2510                 2515                 2520             


Ile Gln  Glu Val Asp Arg Thr  Leu Ala Lys Glu Gly  Ile Lys Arg 
    2525                 2530                 2535             


Gly Glu  Thr Asp His His Ala  Val Ser Arg Gly Ser  Ala Lys Leu 
    2540                 2545                 2550             


Arg Trp  Phe Val Glu Arg Asn  Met Val Thr Pro Glu  Gly Lys Val 
    2555                 2560                 2565             


Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp Ser Tyr  Tyr Cys Gly 
    2570                 2575                 2580             


Gly Leu  Lys Asn Val Arg Glu  Val Lys Gly Leu Thr  Lys Gly Gly 
    2585                 2590                 2595             


Pro Gly  His Glu Glu Pro Ile  Pro Met Ser Thr Tyr  Gly Trp Asn 
    2600                 2605                 2610             


Leu Val  Arg Leu Gln Ser Gly  Val Asp Val Phe Phe  Ile Pro Pro 
    2615                 2620                 2625             


Glu Lys  Cys Asp Thr Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Pro 
    2630                 2635                 2640             


Asn Pro  Thr Val Glu Ala Gly  Arg Thr Leu Arg Val  Leu Asn Leu 
    2645                 2650                 2655             


Val Glu  Asn Trp Leu Asn Asn  Asn Thr Gln Phe Cys  Ile Lys Val 
    2660                 2665                 2670             


Leu Asn  Pro Tyr Met Pro Ser  Val Ile Glu Lys Met  Glu Ala Leu 
    2675                 2680                 2685             


Gln Arg  Lys Tyr Gly Gly Ala  Leu Val Arg Asn Pro  Leu Ser Arg 
    2690                 2695                 2700             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Asn Ala  Ser Gly Asn 
    2705                 2710                 2715             


Ile Val  Ser Ser Val Asn Met  Ile Ser Arg Met Leu  Ile Asn Arg 
    2720                 2725                 2730             


Phe Thr  Met Arg Tyr Lys Lys  Ala Thr Tyr Glu Pro  Asp Val Asp 
    2735                 2740                 2745             


Leu Gly  Ser Gly Thr Arg Asn  Ile Gly Ile Glu Ser  Glu Ile Pro 
    2750                 2755                 2760             


Asn Leu  Asp Ile Ile Gly Lys  Arg Ile Glu Lys Ile  Lys Gln Glu 
    2765                 2770                 2775             


His Glu  Thr Ser Trp His Tyr  Asp Gln Asp His Pro  Tyr Lys Thr 
    2780                 2785                 2790             


Trp Ala  Tyr His Gly Ser Tyr  Glu Thr Lys Gln Thr  Gly Ser Ala 
    2795                 2800                 2805             


Ser Ser  Met Val Asn Gly Val  Val Arg Leu Leu Thr  Lys Pro Trp 
    2810                 2815                 2820             


Asp Val  Val Pro Met Val Thr  Gln Met Ala Met Thr  Asp Thr Thr 
    2825                 2830                 2835             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2840                 2845                 2850             


Thr Gln  Glu Pro Lys Glu Gly  Thr Lys Lys Leu Met  Lys Ile Thr 
    2855                 2860                 2865             


Ala Glu  Trp Leu Trp Lys Glu  Leu Gly Lys Lys Lys  Thr Pro Arg 
    2870                 2875                 2880             


Met Cys  Thr Arg Glu Glu Phe  Thr Arg Lys Val Arg  Ser Asn Ala 
    2885                 2890                 2895             


Ala Leu  Gly Ala Ile Phe Thr  Asp Glu Asn Lys Trp  Lys Ser Ala 
    2900                 2905                 2910             


Arg Glu  Ala Val Glu Asp Ser  Arg Phe Trp Glu Leu  Val Asp Lys 
    2915                 2920                 2925             


Glu Arg  Asn Leu His Leu Glu  Gly Lys Cys Glu Thr  Cys Val Tyr 
    2930                 2935                 2940             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Leu Gly Glu  Phe Gly Lys 
    2945                 2950                 2955             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2960                 2965                 2970             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    2975                 2980                 2985             


Phe Ser  Arg Glu Asn Ser Leu  Ser Gly Val Glu Gly  Glu Gly Leu 
    2990                 2995                 3000             


His Lys  Leu Gly Tyr Ile Leu  Arg Asp Val Ser Lys  Lys Glu Gly 
    3005                 3010                 3015             


Gly Ala  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3020                 3025                 3030             


Thr Leu  Glu Asp Leu Lys Asn  Glu Glu Met Val Thr  Asn His Met 
    3035                 3040                 3045             


Glu Gly  Glu His Lys Lys Leu  Ala Glu Ala Ile Phe  Lys Leu Thr 
    3050                 3055                 3060             


Tyr Gln  Asn Lys Val Val Arg  Val Gln Arg Pro Thr  Pro Arg Gly 
    3065                 3070                 3075             


Thr Val  Met Asp Ile Ile Ser  Arg Arg Asp Gln Arg  Gly Ser Gly 
    3080                 3085                 3090             


Gln Val  Gly Thr Tyr Gly Leu  Asn Thr Phe Thr Asn  Met Glu Ala 
    3095                 3100                 3105             


Gln Leu  Ile Arg Gln Met Glu  Gly Glu Gly Val Phe  Lys Ser Ile 
    3110                 3115                 3120             


Gln His  Leu Thr Ile Thr Glu  Glu Ile Ala Val Gln  Asn Trp Leu 
    3125                 3130                 3135             


Ala Arg  Val Gly Arg Glu Arg  Leu Ser Arg Met Ala  Ile Ser Gly 
    3140                 3145                 3150             


Asp Asp  Cys Val Val Lys Pro  Leu Asp Asp Arg Phe  Ala Ser Ala 
    3155                 3160                 3165             


Leu Thr  Ala Leu Asn Asp Met  Gly Lys Ile Arg Lys  Asp Ile Gln 
    3170                 3175                 3180             


Gln Trp  Glu Pro Ser Arg Gly  Trp Asn Asp Trp Thr  Gln Val Pro 
    3185                 3190                 3195             


Phe Cys  Ser His His Phe His  Glu Leu Ile Met Lys  Asp Gly Arg 
    3200                 3205                 3210             


Val Leu  Val Val Pro Cys Arg  Asn Gln Asp Glu Leu  Ile Gly Arg 
    3215                 3220                 3225             


Ala Arg  Ile Ser Gln Gly Ala  Gly Trp Ser Leu Arg  Glu Thr Ala 
    3230                 3235                 3240             


Cys Leu  Gly Lys Ser Tyr Ala  Gln Met Trp Ser Leu  Met Tyr Phe 
    3245                 3250                 3255             


His Arg  Arg Asp Leu Arg Leu  Ala Ala Asn Ala Ile  Cys Ser Ala 
    3260                 3265                 3270             


Val Pro  Ser His Trp Val Pro  Thr Ser Arg Thr Thr  Trp Ser Ile 
    3275                 3280                 3285             


His Ala  Lys His Glu Trp Met  Thr Thr Glu Asp Met  Leu Thr Val 
    3290                 3295                 3300             


Trp Asn  Arg Val Trp Ile Gln  Glu Asn Pro Trp Met  Glu Asp Lys 
    3305                 3310                 3315             


Thr Pro  Val Glu Ser Trp Glu  Glu Ile Pro Tyr Leu  Gly Lys Arg 
    3320                 3325                 3330             


Glu Asp  Gln Trp Cys Gly Ser  Leu Ile Gly Leu Thr  Ser Arg Ala 
    3335                 3340                 3345             


Thr Trp  Ala Lys Asn Ile Gln  Ala Ala Ile Asn Gln  Val Arg Ser 
    3350                 3355                 3360             


Leu Ile  Gly Asn Glu Glu Tyr  Thr Asp Tyr Met Pro  Ser Met Lys 
    3365                 3370                 3375             


Arg Phe  Arg Arg Glu Glu Glu  Glu Ala Gly Val Leu  Trp 
    3380                 3385                 3390     


<210>  4
<211>  10723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 2, BVS

<400>  4
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acacgtaacg gagaaccaca catgatcgtc      480

agcagacaag agaaagggaa aagtcttctg tttaaaacag aggttggcgt gaacatgtgt      540

accctcatgg ccatggacct tggtgaattg tgtgaagaca caatcacgta cgagtgtccc      600

cttctcaggc agaatgagcc agaagacata gactgttggt gcaactctac gtccacgtgg      660

gtaacttatg ggacgtgtac caccatggga gaacatagaa gagaaaaaag atcagtggca      720

ctcgttccac atgtgggaat gggactggag acacgaactg aaacatggat gtcatcagaa      780

ggggcctgga aacatgtcca gagaattgaa acttggatct tgagacatcc aggcttcacc      840

atgatggcag caatcctggc atacaccata ggaacgacac atttccaaag agccctgatc      900

ttcatcttac tgacagctgt cactccttca atgacaatgc gttgcatagg aatgtcaaat      960

agagactttg tggaaggggt ttcaggagga agctgggttg acatagtctt agaacatgga     1020

agctgtgtga cgacgatggc aaaaaacaaa ccaacattgg attttgaact gataaaaaca     1080

gaagccaaac agcctgccac cctaaggaag tactgtatag aggcaaagct aaccaacaca     1140

acaacagaat ctcgctgccc aacacaaggg gaacccagcc taaatgaaga gcaggacaaa     1200

aggttcgtct gcaaacactc catggtagac agaggatggg gaaatggatg tggactattt     1260

ggaaagggag gcattgtgac ctgtgctatg ttcagatgca aaaagaacat ggaaggaaaa     1320

gttgtgcaac cagaaaactt ggaatacacc attgtgataa cacctcactc aggggaagag     1380

catgcagtcg gaaatgacac aggaaaacat ggcaaggaaa tcaaaataac accacagagt     1440

tccatcacag aagcagaatt gacaggttat ggcactgtca caatggagtg ctctccaaga     1500

acgggcctcg acttcaatga gatggtgttg ctgcagatgg aaaataaagc ttggctggtg     1560

cacaggcaat ggttcctaga cctgccgtta ccatggttgc ccggagcgga cacacaaggg     1620

tcaaattgga tacagaaaga gacattggtc actttcaaaa atccccatgc gaagaaacag     1680

gatgttgttg ttttaggatc ccaagaaggg gccatgcaca cagcacttac aggggccaca     1740

gaaatccaaa tgtcatcagg aaacttactc ttcacaggac atctcaagtg caggctgaga     1800

atggacaagc tacagctcaa aggaatgtca tactctatgt gcacaggaaa gtttaaagtt     1860

gtgaaggaaa tagcagaaac acaacatgga acaatagtta tcagagtgca atatgaaggg     1920

gacggctctc catgcaagat cccttttgag ataatggatt tggaaaaaag acatgtctta     1980

ggtcgcctga ttacagtcaa cccaattgtg acagaaaaag atagcccagt caacatagaa     2040

gcagaacctc catttggaga cagctacatc atcataggag tagagccggg acaactgaag     2100

ctcaactggt ttaagaaagg aagttctatc ggccaaatgt ttgagacaac aatgaggggg     2160

gcgaagagaa tggccatttt aggtgacaca gcctgggatt ttggatcctt gggaggagtg     2220

tttacatcta taggaaaggc tctccaccaa gtctttggag caatctatgg agctgccttc     2280

agtggggttt catggactat gaaaatcctc ataggagtca ttatcacatg gataggaatg     2340

aattcacgca gcacctcact gtctgtgaca ctagtattgg tgggaattgt gacactgtat     2400

ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa caaagaactg     2460

aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag     2520

ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca tgaagaggac     2580

atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca     2640

gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc     2700

aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat     2760

tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt     2820

ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg     2880

gaagttgaag actatggctt tggagtattc accaccaata tatggctaaa attgaaagaa     2940

aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc     3000

gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag     3060

aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc     3120

aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa     3180

cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagctt     3240

gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat     3300

agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc     3360

cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg     3420

gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga     3480

catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa     3540

atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg     3600

acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc     3660

gccactatga cggatgacat aggtatgggc gtgacttatc ttgccctact agcagccttc     3720

aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc caaggaattg     3780

atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga gaccattctt     3840

gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa     3900

aagtatcaat tggcagtgac tatcatggct atcttgtgcg tcccaaacgc agtgatatta     3960

caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgttc     4020

ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc     4080

aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca     4140

ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa     4200

aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt gtgctacgtg     4260

ctcactggac gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac     4320

caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc     4380

atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag aacaggattg     4440

ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg     4500

tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc cccacccatg     4560

ggaaaggctg aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat     4620

tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca     4680

cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag     4740

aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa     4800

gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca aacgaaacct     4860

ggtcttttca aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga     4920

acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt     4980

gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa     5040

gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc     5100

cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga agctataaaa     5160

cggggtttga gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa     5220

gcccttagag gacttccaat aagataccag accccagcca tcagagctgt gcacaccggg     5280

cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt     5340

agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga cccagcaagt     5400

atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc tgggattttt     5460

atgacagcca ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata     5520

gatgaagaaa gagaaatccc tgaacgctcg tggaattccg gacatgaatg ggtcacggat     5580

tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct     5640

tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag     5700

tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat ttcagaaatg     5760

ggtgccaatt tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata     5820

ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt     5880

gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata     5940

tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg     6000

ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga accagagcgt     6060

gaaaaggtgg atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt     6120

gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa     6180

ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta     6240

gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc     6300

agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt taaggaattt     6360

gcagccggaa gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc     6420

ttcatgactc agaaggcaag agacgcactg gacaacttag cagtgctgca cacggctgag     6480

ccaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg     6540

cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgca     6600

aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggctag catcctccta     6660

tggtacgcac aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc     6720

atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc     6780

tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc     6840

ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc     6900

aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc cgtggccaca     6960

acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta     7020

acagctatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca     7080

aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata     7140

actctcacag cagctttttt cttattggta gcacattatg ccatcatagg gccaggactc     7200

caagcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca     7260

actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa     7320

aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg     7380

actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc cacattgtgg     7440

gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt     7500

agagggagtt acttggccgg agctggactt ctcttttcta ttatgaagaa cacaaccaac     7560

acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg     7620

aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat     7680

agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc tgtgtcgcga     7740

ggctcagcaa aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta     7800

gtggacctcg gttgtggcag aggaggctgg tcatactatt gtggaggact aaagaatgta     7860

agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca     7920

acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca     7980

gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc cacagtggaa     8040

gcaggacgaa cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa     8100

ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta     8160

caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag     8220

atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg     8280

atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc ggatgttgac     8340

ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt     8400

gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac     8460

cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca     8520

tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg     8580

gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt ttttaaagag     8640

aaagtggaca cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca     8700

gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa     8760

gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccgtattcac tgatgagaac     8820

aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag     8880

gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa     8940

agagagaaga agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg     9000

tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg     9060

ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac     9120

attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga     9180

tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac aaaccacatg     9240

gaaggagaac acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg     9300

gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac     9360

caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc     9420

caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc     9480

acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga     9540

atggccatca gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct     9600

ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca     9660

agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc     9720

atgaaagacg gtcgcgtact cgttgttcca tgtagaaacc aagatgaact gattggcaga     9780

gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt ggggaagtct     9840

tacgcccaaa tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat     9900

gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgaacaac ctggtccata     9960

catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg    10020

attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca    10080

tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac aagcagggcc    10140

acctgggcaa agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa    10200

gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga    10260

gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc    10320

catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca    10380

ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg    10440

tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc    10500

ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga    10560

agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag    10620

catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca    10680

gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct                      10723


<210>  5
<211>  3391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 2, BVS

<400>  5

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val 
        115                 120                 125             


Ser Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Val Gly 
    130                 135                 140                 


Val Asn Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu 
145                 150                 155                 160 


Asp Thr Ile Thr Tyr Glu Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp 
225                 230                 235                 240 


Ile Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala Tyr 
                245                 250                 255     


Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu 
            260                 265                 270         


Thr Ala Val Thr Pro Ser Met Thr Met Arg Cys Ile Gly Met Ser Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val 
    290                 295                 300                 


Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu 
                325                 330                 335     


Arg Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys 
        355                 360                 365             


Arg Phe Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Arg 
385                 390                 395                 400 


Cys Lys Lys Asn Met Glu Gly Lys Val Val Gln Pro Glu Asn Leu Glu 
                405                 410                 415     


Tyr Thr Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly 
            420                 425                 430         


Asn Asp Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser 
        435                 440                 445             


Ser Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu 
    450                 455                 460                 


Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln 
465                 470                 475                 480 


Met Glu Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile 
            500                 505                 510         


Gln Lys Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln 
        515                 520                 525             


Asp Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu 
    530                 535                 540                 


Thr Gly Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr 
545                 550                 555                 560 


Gly His Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly 
                565                 570                 575     


Met Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly 
        595                 600                 605             


Asp Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys 
    610                 615                 620                 


Arg His Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu 
625                 630                 635                 640 


Lys Asp Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser 
                645                 650                 655     


Tyr Ile Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe 
            660                 665                 670         


Lys Lys Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly 
        675                 680                 685             


Ala Lys Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Leu Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe 
705                 710                 715                 720 


Gly Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys 
                725                 730                 735     


Ile Leu Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser 
            740                 745                 750         


Thr Ser Leu Ser Val Thr Leu Val Leu Val Gly Ile Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 
    770                 775                 780                 


Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 
                805                 810                 815     


Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile 
            820                 825                 830         


Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 
        835                 840                 845             


Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 
    850                 855                 860                 


Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 
865                 870                 875                 880 


Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 
                885                 890                 895     


Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 
            900                 905                 910         


Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Asn Cys His Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Asn Leu Ala 
    1010                 1015                 1020             


Gly Pro  Val Ser Gln His Asn  Tyr Arg Pro Gly Tyr  His Thr Gln 
    1025                 1030                 1035             


Ile Thr  Gly Pro Trp His Leu  Gly Lys Leu Glu Met  Asp Phe Asp 
    1040                 1045                 1050             


Phe Cys  Asp Gly Thr Thr Val  Val Val Thr Glu Asp  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Ala Ser Gly  Lys Leu Ile 
    1070                 1075                 1080             


Thr Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr 
    1085                 1090                 1095             


Arg Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Leu 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Asn Ser Leu Val  Thr Ala Gly 
    1115                 1120                 1125             


His Gly  Gln Val Asp Asn Phe  Ser Leu Gly Val Leu  Gly Met Ala 
    1130                 1135                 1140             


Leu Phe  Leu Glu Glu Met Leu  Arg Thr Arg Val Gly  Thr Lys His 
    1145                 1150                 1155             


Ala Ile  Leu Leu Val Ala Val  Ser Phe Val Thr Leu  Ile Thr Gly 
    1160                 1165                 1170             


Asn Met  Ser Phe Arg Asp Leu  Gly Arg Val Met Val  Met Val Gly 
    1175                 1180                 1185             


Ala Thr  Met Thr Asp Asp Ile  Gly Met Gly Val Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Leu  Ala Ala Phe Lys Val  Arg Pro Thr Phe Ala  Ala Gly Leu 
    1205                 1210                 1215             


Leu Leu  Arg Lys Leu Thr Ser  Lys Glu Leu Met Met  Thr Thr Ile 
    1220                 1225                 1230             


Gly Ile  Val Leu Leu Ser Gln  Ser Thr Ile Pro Glu  Thr Ile Leu 
    1235                 1240                 1245             


Glu Leu  Thr Asp Ala Leu Ala  Leu Gly Met Met Val  Leu Lys Met 
    1250                 1255                 1260             


Val Arg  Asn Met Glu Lys Tyr  Gln Leu Ala Val Thr  Ile Met Ala 
    1265                 1270                 1275             


Ile Leu  Cys Val Pro Asn Ala  Val Ile Leu Gln Asn  Ala Trp Lys 
    1280                 1285                 1290             


Val Ser  Cys Thr Ile Leu Ala  Val Val Ser Val Ser  Pro Leu Phe 
    1295                 1300                 1305             


Leu Thr  Ser Ser Gln Gln Lys  Thr Asp Trp Ile Pro  Leu Ala Leu 
    1310                 1315                 1320             


Thr Ile  Lys Gly Leu Asn Pro  Thr Ala Ile Phe Leu  Thr Thr Leu 
    1325                 1330                 1335             


Ser Arg  Thr Ser Lys Lys Arg  Ser Trp Pro Leu Asn  Glu Ala Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Met Val Ser  Ile Leu Ala Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Ile Pro Met Thr Gly  Pro Leu Val Ala Gly  Gly Leu Leu 
    1370                 1375                 1380             


Thr Val  Cys Tyr Val Leu Thr  Gly Arg Ser Ala Asp  Leu Glu Leu 
    1385                 1390                 1395             


Glu Arg  Ala Ala Asp Val Lys  Trp Glu Asp Gln Ala  Glu Ile Ser 
    1400                 1405                 1410             


Gly Ser  Ser Pro Ile Leu Ser  Ile Thr Ile Ser Glu  Asp Gly Ser 
    1415                 1420                 1425             


Met Ser  Ile Lys Asn Glu Glu  Glu Glu Gln Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Ile Arg  Thr Gly Leu Leu Val  Ile Ser Gly Leu Phe  Pro Val Ser 
    1445                 1450                 1455             


Ile Pro  Ile Thr Ala Ala Ala  Trp Tyr Leu Trp Glu  Val Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ala Gly Val Leu Trp  Asp Val Pro Ser Pro  Pro Pro Met 
    1475                 1480                 1485             


Gly Lys  Ala Glu Leu Glu Asp  Gly Ala Tyr Arg Ile  Lys Gln Lys 
    1490                 1495                 1500             


Gly Ile  Leu Gly Tyr Ser Gln  Ile Gly Ala Gly Val  Tyr Lys Glu 
    1505                 1510                 1515             


Gly Thr  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met His  Lys Gly Lys Arg Ile  Glu Pro Ser Trp Ala  Asp Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Lys Leu  Glu Gly Glu 
    1550                 1555                 1560             


Trp Lys  Glu Gly Glu Glu Val  Gln Val Leu Ala Leu  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Arg Ala Val Gln  Thr Lys Pro Gly Leu  Phe Lys Thr 
    1580                 1585                 1590             


Asn Ala  Gly Thr Ile Gly Ala  Val Ser Leu Asp Phe  Ser Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Ile  Asp Lys Lys Gly Lys  Val Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Arg Ser Gly Ala  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Thr Glu Lys  Ser Ile Glu Asp Asn  Pro Glu Ile 
    1640                 1645                 1650             


Glu Asp  Asp Ile Phe Arg Lys  Arg Arg Leu Thr Ile  Met Asp Leu 
    1655                 1660                 1665             


His Pro  Gly Ala Gly Lys Thr  Lys Arg Tyr Leu Pro  Ala Ile Val 
    1670                 1675                 1680             


Arg Glu  Ala Ile Lys Arg Gly  Leu Arg Thr Leu Ile  Leu Ala Pro 
    1685                 1690                 1695             


Thr Arg  Val Val Ala Ala Glu  Met Glu Glu Ala Leu  Arg Gly Leu 
    1700                 1705                 1710             


Pro Ile  Arg Tyr Gln Thr Pro  Ala Ile Arg Ala Val  His Thr Gly 
    1715                 1720                 1725             


Arg Glu  Ile Val Asp Leu Met  Cys His Ala Thr Phe  Thr Met Arg 
    1730                 1735                 1740             


Leu Leu  Ser Pro Val Arg Val  Pro Asn Tyr Asn Leu  Ile Ile Met 
    1745                 1750                 1755             


Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly 
    1760                 1765                 1770             


Tyr Ile  Ser Thr Arg Val Glu  Met Gly Glu Ala Ala  Gly Ile Phe 
    1775                 1780                 1785             


Met Thr  Ala Thr Pro Pro Gly  Ser Arg Asp Pro Phe  Pro Gln Ser 
    1790                 1795                 1800             


Asn Ala  Pro Ile Ile Asp Glu  Glu Arg Glu Ile Pro  Glu Arg Ser 
    1805                 1810                 1815             


Trp Asn  Ser Gly His Glu Trp  Val Thr Asp Phe Lys  Gly Lys Thr 
    1820                 1825                 1830             


Val Trp  Phe Val Pro Ser Ile  Lys Ala Gly Asn Asp  Ile Ala Ala 
    1835                 1840                 1845             


Cys Leu  Arg Lys Asn Gly Lys  Lys Val Ile Gln Leu  Ser Arg Lys 
    1850                 1855                 1860             


Thr Phe  Asp Ser Glu Tyr Val  Lys Thr Arg Thr Asn  Asp Trp Asp 
    1865                 1870                 1875             


Phe Val  Val Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys 
    1880                 1885                 1890             


Ala Glu  Arg Val Ile Asp Pro  Arg Arg Cys Met Lys  Pro Val Ile 
    1895                 1900                 1905             


Leu Thr  Asp Gly Glu Glu Arg  Val Ile Leu Ala Gly  Pro Met Pro 
    1910                 1915                 1920             


Val Thr  His Ser Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg 
    1925                 1930                 1935             


Asn Pro  Lys Asn Glu Asn Asp  Gln Tyr Ile Tyr Met  Gly Glu Pro 
    1940                 1945                 1950             


Leu Glu  Asn Asp Glu Asp Cys  Ala His Trp Lys Glu  Ala Lys Met 
    1955                 1960                 1965             


Leu Leu  Asp Asn Ile Asn Thr  Pro Glu Gly Ile Ile  Pro Ser Met 
    1970                 1975                 1980             


Phe Glu  Pro Glu Arg Glu Lys  Val Asp Ala Ile Asp  Gly Glu Tyr 
    1985                 1990                 1995             


Arg Leu  Arg Gly Glu Ala Arg  Lys Thr Phe Val Asp  Leu Met Arg 
    2000                 2005                 2010             


Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr Arg Val  Ala Ala Glu 
    2015                 2020                 2025             


Gly Ile  Asn Tyr Ala Asp Arg  Arg Trp Cys Phe Asp  Gly Val Lys 
    2030                 2035                 2040             


Asn Asn  Gln Ile Leu Glu Glu  Asn Val Glu Val Glu  Ile Trp Thr 
    2045                 2050                 2055             


Lys Glu  Gly Glu Arg Lys Lys  Leu Lys Pro Arg Trp  Leu Asp Ala 
    2060                 2065                 2070             


Arg Ile  Tyr Ser Asp Pro Leu  Ala Leu Lys Glu Phe  Lys Glu Phe 
    2075                 2080                 2085             


Ala Ala  Gly Arg Lys Ser Leu  Thr Leu Asn Leu Ile  Thr Glu Met 
    2090                 2095                 2100             


Gly Arg  Leu Pro Thr Phe Met  Thr Gln Lys Ala Arg  Asp Ala Leu 
    2105                 2110                 2115             


Asp Asn  Leu Ala Val Leu His  Thr Ala Glu Pro Gly  Gly Arg Ala 
    2120                 2125                 2130             


Tyr Asn  His Ala Leu Ser Glu  Leu Pro Glu Thr Leu  Glu Thr Leu 
    2135                 2140                 2145             


Leu Leu  Leu Thr Leu Leu Ala  Thr Val Thr Gly Gly  Ile Phe Leu 
    2150                 2155                 2160             


Phe Leu  Met Ser Ala Arg Gly  Ile Gly Lys Met Thr  Leu Gly Met 
    2165                 2170                 2175             


Cys Cys  Ile Ile Thr Ala Ser  Ile Leu Leu Trp Tyr  Ala Gln Ile 
    2180                 2185                 2190             


Gln Pro  His Trp Ile Ala Ala  Ser Ile Ile Leu Glu  Phe Phe Leu 
    2195                 2200                 2205             


Ile Val  Leu Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Thr Pro Gln 
    2210                 2215                 2220             


Asp Asn  Gln Leu Thr Tyr Val  Val Ile Ala Ile Leu  Thr Val Val 
    2225                 2230                 2235             


Ala Ala  Thr Met Ala Asn Glu  Met Gly Phe Leu Glu  Lys Thr Lys 
    2240                 2245                 2250             


Lys Asp  Leu Gly Leu Gly Ser  Ile Ala Thr Gln Gln  Pro Glu Ser 
    2255                 2260                 2265             


Asn Ile  Leu Asp Ile Asp Leu  Arg Pro Ala Ser Ala  Trp Thr Leu 
    2270                 2275                 2280             


Tyr Ala  Val Ala Thr Thr Phe  Val Thr Pro Met Leu  Arg His Ser 
    2285                 2290                 2295             


Ile Glu  Asn Ser Ser Val Asn  Val Ser Leu Thr Ala  Ile Ala Asn 
    2300                 2305                 2310             


Gln Ala  Thr Val Leu Met Gly  Leu Gly Lys Gly Trp  Pro Leu Ser 
    2315                 2320                 2325             


Lys Met  Asp Ile Gly Val Pro  Leu Leu Ala Ile Gly  Cys Tyr Ser 
    2330                 2335                 2340             


Gln Val  Asn Pro Ile Thr Leu  Thr Ala Ala Phe Phe  Leu Leu Val 
    2345                 2350                 2355             


Ala His  Tyr Ala Ile Ile Gly  Pro Gly Leu Gln Ala  Lys Ala Thr 
    2360                 2365                 2370             


Arg Glu  Ala Gln Lys Arg Ala  Ala Ala Gly Ile Met  Lys Asn Pro 
    2375                 2380                 2385             


Thr Val  Asp Gly Ile Thr Val  Ile Asp Leu Asp Pro  Ile Pro Tyr 
    2390                 2395                 2400             


Asp Pro  Lys Phe Glu Lys Gln  Leu Gly Gln Val Met  Leu Leu Val 
    2405                 2410                 2415             


Leu Cys  Val Thr Gln Val Leu  Met Met Arg Thr Thr  Trp Ala Leu 
    2420                 2425                 2430             


Cys Glu  Ala Leu Thr Leu Ala  Thr Gly Pro Ile Ser  Thr Leu Trp 
    2435                 2440                 2445             


Glu Gly  Asn Pro Gly Arg Phe  Trp Asn Thr Thr Ile  Ala Val Ser 
    2450                 2455                 2460             


Met Ala  Asn Ile Phe Arg Gly  Ser Tyr Leu Ala Gly  Ala Gly Leu 
    2465                 2470                 2475             


Leu Phe  Ser Ile Met Lys Asn  Thr Thr Asn Thr Arg  Arg Gly Thr 
    2480                 2485                 2490             


Gly Asn  Ile Gly Glu Thr Leu  Gly Glu Lys Trp Lys  Ser Arg Leu 
    2495                 2500                 2505             


Asn Ala  Leu Gly Lys Ser Glu  Phe Gln Ile Tyr Lys  Lys Ser Gly 
    2510                 2515                 2520             


Ile Gln  Glu Val Asp Arg Thr  Leu Ala Lys Glu Gly  Ile Lys Arg 
    2525                 2530                 2535             


Gly Glu  Thr Asp His His Ala  Val Ser Arg Gly Ser  Ala Lys Leu 
    2540                 2545                 2550             


Arg Trp  Phe Val Glu Arg Asn  Met Val Thr Pro Glu  Gly Lys Val 
    2555                 2560                 2565             


Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp Ser Tyr  Tyr Cys Gly 
    2570                 2575                 2580             


Gly Leu  Lys Asn Val Arg Glu  Val Lys Gly Leu Thr  Lys Gly Gly 
    2585                 2590                 2595             


Pro Gly  His Glu Glu Pro Ile  Pro Met Ser Thr Tyr  Gly Trp Asn 
    2600                 2605                 2610             


Leu Val  Arg Leu Gln Ser Gly  Val Asp Val Phe Phe  Ile Pro Pro 
    2615                 2620                 2625             


Glu Lys  Cys Asp Thr Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Pro 
    2630                 2635                 2640             


Asn Pro  Thr Val Glu Ala Gly  Arg Thr Leu Arg Val  Leu Asn Leu 
    2645                 2650                 2655             


Val Glu  Asn Trp Leu Asn Asn  Asn Thr Gln Phe Cys  Ile Lys Val 
    2660                 2665                 2670             


Leu Asn  Pro Tyr Met Pro Ser  Val Ile Glu Lys Met  Glu Ala Leu 
    2675                 2680                 2685             


Gln Arg  Lys Tyr Gly Gly Ala  Leu Val Arg Asn Pro  Leu Ser Arg 
    2690                 2695                 2700             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Asn Ala  Ser Gly Asn 
    2705                 2710                 2715             


Ile Val  Ser Ser Val Asn Met  Ile Ser Arg Met Leu  Ile Asn Arg 
    2720                 2725                 2730             


Phe Thr  Met Arg Tyr Lys Lys  Ala Thr Tyr Glu Pro  Asp Val Asp 
    2735                 2740                 2745             


Leu Gly  Ser Gly Thr Arg Asn  Ile Gly Ile Glu Ser  Glu Ile Pro 
    2750                 2755                 2760             


Asn Leu  Asp Ile Ile Gly Lys  Arg Ile Glu Lys Ile  Lys Gln Glu 
    2765                 2770                 2775             


His Glu  Thr Ser Trp His Tyr  Asp Gln Asp His Pro  Tyr Lys Thr 
    2780                 2785                 2790             


Trp Ala  Tyr His Gly Ser Tyr  Glu Thr Lys Gln Thr  Gly Ser Ala 
    2795                 2800                 2805             


Ser Ser  Met Val Asn Gly Val  Val Arg Leu Leu Thr  Lys Pro Trp 
    2810                 2815                 2820             


Asp Val  Val Pro Met Val Thr  Gln Met Ala Met Thr  Asp Thr Thr 
    2825                 2830                 2835             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2840                 2845                 2850             


Thr Gln  Glu Pro Lys Glu Gly  Thr Lys Lys Leu Met  Lys Ile Thr 
    2855                 2860                 2865             


Ala Glu  Trp Leu Trp Lys Glu  Leu Gly Lys Lys Lys  Thr Pro Arg 
    2870                 2875                 2880             


Met Cys  Thr Arg Glu Glu Phe  Thr Arg Lys Val Arg  Ser Asn Ala 
    2885                 2890                 2895             


Ala Leu  Gly Ala Val Phe Thr  Asp Glu Asn Lys Trp  Lys Ser Ala 
    2900                 2905                 2910             


Arg Glu  Ala Val Glu Asp Ser  Arg Phe Trp Glu Leu  Val Asp Lys 
    2915                 2920                 2925             


Glu Arg  Asn Leu His Leu Glu  Gly Lys Cys Glu Thr  Cys Val Tyr 
    2930                 2935                 2940             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Leu Gly Glu  Phe Gly Lys 
    2945                 2950                 2955             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2960                 2965                 2970             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    2975                 2980                 2985             


Phe Ser  Arg Glu Asn Ser Leu  Ser Gly Val Glu Gly  Glu Gly Leu 
    2990                 2995                 3000             


His Lys  Leu Gly Tyr Ile Leu  Arg Asp Val Ser Lys  Lys Glu Gly 
    3005                 3010                 3015             


Gly Ala  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3020                 3025                 3030             


Thr Leu  Glu Asp Leu Lys Asn  Glu Glu Met Val Thr  Asn His Met 
    3035                 3040                 3045             


Glu Gly  Glu His Lys Lys Leu  Ala Glu Ala Ile Phe  Lys Leu Thr 
    3050                 3055                 3060             


Tyr Gln  Asn Lys Val Val Arg  Val Gln Arg Pro Thr  Pro Arg Gly 
    3065                 3070                 3075             


Thr Val  Met Asp Ile Ile Ser  Arg Arg Asp Gln Arg  Gly Ser Gly 
    3080                 3085                 3090             


Gln Val  Gly Thr Tyr Gly Leu  Asn Thr Phe Thr Asn  Met Glu Ala 
    3095                 3100                 3105             


Gln Leu  Ile Arg Gln Met Glu  Gly Glu Gly Val Phe  Lys Ser Ile 
    3110                 3115                 3120             


Gln His  Leu Thr Ile Thr Glu  Glu Ile Ala Val Gln  Asn Trp Leu 
    3125                 3130                 3135             


Ala Arg  Val Gly Arg Glu Arg  Leu Ser Arg Met Ala  Ile Ser Gly 
    3140                 3145                 3150             


Asp Asp  Cys Val Val Lys Pro  Leu Asp Asp Arg Phe  Ala Ser Ala 
    3155                 3160                 3165             


Leu Thr  Ala Leu Asn Asp Met  Gly Lys Ile Arg Lys  Asp Ile Gln 
    3170                 3175                 3180             


Gln Trp  Glu Pro Ser Arg Gly  Trp Asn Asp Trp Thr  Gln Val Pro 
    3185                 3190                 3195             


Phe Cys  Ser His His Phe His  Glu Leu Ile Met Lys  Asp Gly Arg 
    3200                 3205                 3210             


Val Leu  Val Val Pro Cys Arg  Asn Gln Asp Glu Leu  Ile Gly Arg 
    3215                 3220                 3225             


Ala Arg  Ile Ser Gln Gly Ala  Gly Trp Ser Leu Arg  Glu Thr Ala 
    3230                 3235                 3240             


Cys Leu  Gly Lys Ser Tyr Ala  Gln Met Trp Ser Leu  Met Tyr Phe 
    3245                 3250                 3255             


His Arg  Arg Asp Leu Arg Leu  Ala Ala Asn Ala Ile  Cys Ser Ala 
    3260                 3265                 3270             


Val Pro  Ser His Trp Val Pro  Thr Ser Arg Thr Thr  Trp Ser Ile 
    3275                 3280                 3285             


His Ala  Lys His Glu Trp Met  Thr Thr Glu Asp Met  Leu Thr Val 
    3290                 3295                 3300             


Trp Asn  Arg Val Trp Ile Gln  Glu Asn Pro Trp Met  Glu Asp Lys 
    3305                 3310                 3315             


Thr Pro  Val Glu Ser Trp Glu  Glu Ile Pro Tyr Leu  Gly Lys Arg 
    3320                 3325                 3330             


Glu Asp  Gln Trp Cys Gly Ser  Leu Ile Gly Leu Thr  Ser Arg Ala 
    3335                 3340                 3345             


Thr Trp  Ala Lys Asn Ile Gln  Ala Ala Ile Asn Gln  Val Arg Ser 
    3350                 3355                 3360             


Leu Ile  Gly Asn Glu Glu Tyr  Thr Asp Tyr Met Pro  Ser Met Lys 
    3365                 3370                 3375             


Arg Phe  Arg Arg Glu Glu Glu  Glu Ala Gly Val Leu  Trp 
    3380                 3385                 3390     


<210>  6
<211>  3391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 2, MVS

<400>  6

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val 
        115                 120                 125             


Ser Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Val Gly 
    130                 135                 140                 


Val Asn Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu 
145                 150                 155                 160 


Asp Thr Ile Thr Tyr Glu Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp 
225                 230                 235                 240 


Ile Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala Tyr 
                245                 250                 255     


Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu 
            260                 265                 270         


Thr Ala Val Thr Pro Ser Met Thr Met Arg Cys Ile Gly Met Ser Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val 
    290                 295                 300                 


Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu 
                325                 330                 335     


Arg Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys 
        355                 360                 365             


Arg Phe Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Arg 
385                 390                 395                 400 


Cys Lys Lys Asn Met Glu Gly Lys Val Val Gln Pro Glu Asn Leu Glu 
                405                 410                 415     


Tyr Thr Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly 
            420                 425                 430         


Asn Asp Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser 
        435                 440                 445             


Ser Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu 
    450                 455                 460                 


Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln 
465                 470                 475                 480 


Met Glu Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile 
            500                 505                 510         


Gln Lys Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln 
        515                 520                 525             


Asp Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu 
    530                 535                 540                 


Thr Gly Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr 
545                 550                 555                 560 


Gly His Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly 
                565                 570                 575     


Met Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly 
        595                 600                 605             


Asp Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys 
    610                 615                 620                 


Arg His Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu 
625                 630                 635                 640 


Lys Asp Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser 
                645                 650                 655     


Tyr Ile Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe 
            660                 665                 670         


Lys Lys Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly 
        675                 680                 685             


Ala Lys Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Leu Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe 
705                 710                 715                 720 


Gly Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys 
                725                 730                 735     


Ile Leu Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser 
            740                 745                 750         


Thr Ser Leu Ser Val Thr Leu Val Leu Val Gly Ile Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 
    770                 775                 780                 


Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 
                805                 810                 815     


Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile 
            820                 825                 830         


Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 
        835                 840                 845             


Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 
    850                 855                 860                 


Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 
865                 870                 875                 880 


Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 
                885                 890                 895     


Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 
            900                 905                 910         


Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Asn Cys His Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Asn Leu Ala 
    1010                 1015                 1020             


Gly Pro  Val Ser Gln His Asn  Tyr Arg Pro Gly Tyr  His Thr Gln 
    1025                 1030                 1035             


Ile Thr  Gly Pro Trp His Leu  Gly Lys Leu Glu Met  Asp Phe Asp 
    1040                 1045                 1050             


Phe Cys  Asp Gly Thr Thr Val  Val Val Thr Glu Asp  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Ala Ser Gly  Lys Leu Ile 
    1070                 1075                 1080             


Thr Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr 
    1085                 1090                 1095             


Arg Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Leu 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Asn Ser Leu Val  Thr Ala Gly 
    1115                 1120                 1125             


His Gly  Gln Val Asp Asn Phe  Ser Leu Gly Val Leu  Gly Met Ala 
    1130                 1135                 1140             


Leu Phe  Leu Glu Glu Met Leu  Arg Thr Arg Val Gly  Thr Lys His 
    1145                 1150                 1155             


Ala Ile  Leu Leu Val Ala Val  Ser Phe Val Thr Leu  Ile Thr Gly 
    1160                 1165                 1170             


Asn Met  Ser Phe Arg Asp Leu  Gly Arg Val Met Val  Met Val Gly 
    1175                 1180                 1185             


Ala Thr  Met Thr Asp Asp Ile  Gly Met Gly Val Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Leu  Ala Ala Phe Lys Val  Arg Pro Thr Phe Ala  Ala Gly Leu 
    1205                 1210                 1215             


Leu Leu  Arg Lys Leu Thr Ser  Lys Glu Leu Met Met  Thr Thr Ile 
    1220                 1225                 1230             


Gly Ile  Val Leu Leu Ser Gln  Ser Thr Ile Pro Glu  Thr Ile Leu 
    1235                 1240                 1245             


Glu Leu  Thr Asp Ala Leu Ala  Leu Gly Met Met Val  Leu Lys Met 
    1250                 1255                 1260             


Val Arg  Asn Met Glu Lys Tyr  Gln Leu Ala Val Thr  Ile Met Ala 
    1265                 1270                 1275             


Ile Leu  Cys Val Pro Asn Ala  Val Ile Leu Gln Asn  Ala Trp Lys 
    1280                 1285                 1290             


Val Ser  Cys Thr Ile Leu Ala  Val Val Ser Val Ser  Pro Leu Phe 
    1295                 1300                 1305             


Leu Thr  Ser Ser Gln Gln Lys  Thr Asp Trp Ile Pro  Leu Ala Leu 
    1310                 1315                 1320             


Thr Ile  Lys Gly Leu Asn Pro  Thr Ala Ile Phe Leu  Thr Thr Leu 
    1325                 1330                 1335             


Ser Arg  Thr Ser Lys Lys Arg  Ser Trp Pro Leu Asn  Glu Ala Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Met Val Ser  Ile Leu Ala Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Ile Pro Met Thr Gly  Pro Leu Val Ala Gly  Gly Leu Leu 
    1370                 1375                 1380             


Thr Val  Cys Tyr Val Leu Thr  Gly Arg Ser Ala Asp  Leu Glu Leu 
    1385                 1390                 1395             


Glu Arg  Ala Ala Asp Val Lys  Trp Glu Asp Gln Ala  Glu Ile Ser 
    1400                 1405                 1410             


Gly Ser  Ser Pro Ile Leu Ser  Ile Thr Ile Ser Glu  Asp Gly Ser 
    1415                 1420                 1425             


Met Ser  Ile Lys Asn Glu Glu  Glu Glu Gln Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Ile Arg  Thr Gly Leu Leu Val  Ile Ser Gly Leu Phe  Pro Val Ser 
    1445                 1450                 1455             


Ile Pro  Ile Thr Ala Ala Ala  Trp Tyr Leu Trp Glu  Val Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ala Gly Val Leu Trp  Asp Val Pro Ser Pro  Pro Pro Met 
    1475                 1480                 1485             


Gly Lys  Ala Glu Leu Glu Asp  Gly Ala Tyr Arg Ile  Lys Gln Lys 
    1490                 1495                 1500             


Gly Ile  Leu Gly Tyr Ser Gln  Ile Gly Ala Gly Val  Tyr Lys Glu 
    1505                 1510                 1515             


Gly Thr  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met His  Lys Gly Lys Arg Ile  Glu Pro Ser Trp Ala  Asp Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Lys Leu  Glu Gly Glu 
    1550                 1555                 1560             


Trp Lys  Glu Gly Glu Glu Val  Gln Val Leu Ala Leu  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Arg Ala Val Gln  Thr Lys Pro Gly Leu  Phe Lys Thr 
    1580                 1585                 1590             


Asn Ala  Gly Thr Ile Gly Ala  Val Ser Leu Asp Phe  Ser Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Ile  Asp Lys Lys Gly Lys  Val Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Arg Ser Gly Ala  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Thr Glu Lys  Ser Ile Glu Asp Asn  Pro Glu Ile 
    1640                 1645                 1650             


Glu Asp  Asp Ile Phe Arg Lys  Arg Arg Leu Thr Ile  Met Asp Leu 
    1655                 1660                 1665             


His Pro  Gly Ala Gly Lys Thr  Lys Arg Tyr Leu Pro  Ala Ile Val 
    1670                 1675                 1680             


Arg Glu  Ala Ile Lys Arg Gly  Leu Arg Thr Leu Ile  Leu Ala Pro 
    1685                 1690                 1695             


Thr Arg  Val Val Ala Ala Glu  Met Glu Glu Ala Leu  Arg Gly Leu 
    1700                 1705                 1710             


Pro Ile  Arg Tyr Gln Thr Pro  Ala Ile Arg Ala Val  His Thr Gly 
    1715                 1720                 1725             


Arg Glu  Ile Val Asp Leu Met  Cys His Ala Thr Phe  Thr Met Arg 
    1730                 1735                 1740             


Leu Leu  Ser Pro Val Arg Val  Pro Asn Tyr Asn Leu  Ile Ile Met 
    1745                 1750                 1755             


Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly 
    1760                 1765                 1770             


Tyr Ile  Ser Thr Arg Val Glu  Met Gly Glu Ala Ala  Gly Ile Phe 
    1775                 1780                 1785             


Met Thr  Ala Thr Pro Pro Gly  Ser Arg Asp Pro Phe  Pro Gln Ser 
    1790                 1795                 1800             


Asn Ala  Pro Ile Ile Asp Glu  Glu Arg Glu Ile Pro  Glu Arg Ser 
    1805                 1810                 1815             


Trp Asn  Ser Gly His Glu Trp  Val Thr Asp Phe Lys  Gly Lys Thr 
    1820                 1825                 1830             


Val Trp  Phe Val Pro Ser Ile  Lys Ala Gly Asn Asp  Ile Ala Ala 
    1835                 1840                 1845             


Cys Leu  Arg Lys Asn Gly Lys  Lys Val Ile Gln Leu  Ser Arg Lys 
    1850                 1855                 1860             


Thr Phe  Asp Ser Glu Tyr Val  Lys Thr Arg Thr Asn  Asp Trp Asp 
    1865                 1870                 1875             


Phe Val  Val Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys 
    1880                 1885                 1890             


Ala Glu  Arg Val Ile Asp Pro  Arg Arg Cys Met Lys  Pro Val Ile 
    1895                 1900                 1905             


Leu Thr  Asp Gly Glu Glu Arg  Val Ile Leu Ala Gly  Pro Met Pro 
    1910                 1915                 1920             


Val Thr  His Ser Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg 
    1925                 1930                 1935             


Asn Pro  Lys Asn Glu Asn Asp  Gln Tyr Ile Tyr Met  Gly Glu Pro 
    1940                 1945                 1950             


Leu Glu  Asn Asp Glu Asp Cys  Ala His Trp Lys Glu  Ala Lys Met 
    1955                 1960                 1965             


Leu Leu  Asp Asn Ile Asn Thr  Pro Glu Gly Ile Ile  Pro Ser Met 
    1970                 1975                 1980             


Phe Glu  Pro Glu Arg Glu Lys  Val Asp Ala Ile Asp  Gly Glu Tyr 
    1985                 1990                 1995             


Arg Leu  Arg Gly Glu Ala Arg  Lys Thr Phe Val Asp  Leu Met Arg 
    2000                 2005                 2010             


Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr Arg Val  Ala Ala Glu 
    2015                 2020                 2025             


Gly Ile  Asn Tyr Ala Asp Arg  Arg Trp Cys Phe Asp  Gly Val Lys 
    2030                 2035                 2040             


Asn Asn  Gln Ile Leu Glu Glu  Asn Val Glu Val Glu  Ile Trp Thr 
    2045                 2050                 2055             


Lys Glu  Gly Glu Arg Lys Lys  Leu Lys Pro Arg Trp  Leu Asp Ala 
    2060                 2065                 2070             


Arg Ile  Tyr Ser Asp Pro Leu  Ala Leu Lys Glu Phe  Lys Glu Phe 
    2075                 2080                 2085             


Ala Ala  Gly Arg Lys Ser Leu  Thr Leu Asn Leu Ile  Thr Glu Met 
    2090                 2095                 2100             


Gly Arg  Leu Pro Thr Phe Met  Thr Gln Lys Ala Arg  Asp Ala Leu 
    2105                 2110                 2115             


Asp Asn  Leu Ala Val Leu His  Thr Ala Glu Ala Gly  Gly Arg Ala 
    2120                 2125                 2130             


Tyr Asn  His Ala Leu Ser Glu  Leu Pro Glu Thr Leu  Glu Thr Leu 
    2135                 2140                 2145             


Leu Leu  Leu Thr Leu Leu Ala  Thr Val Thr Gly Gly  Ile Phe Leu 
    2150                 2155                 2160             


Phe Leu  Met Ser Ala Arg Gly  Ile Gly Lys Met Thr  Leu Gly Met 
    2165                 2170                 2175             


Cys Cys  Ile Ile Thr Ala Ser  Ile Leu Leu Trp Tyr  Ala Gln Ile 
    2180                 2185                 2190             


Gln Pro  His Trp Ile Ala Ala  Ser Ile Ile Leu Glu  Phe Phe Leu 
    2195                 2200                 2205             


Ile Val  Leu Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Thr Pro Gln 
    2210                 2215                 2220             


Asp Asn  Gln Leu Thr Tyr Val  Val Ile Ala Ile Leu  Thr Val Val 
    2225                 2230                 2235             


Ala Ala  Thr Met Ala Asn Glu  Met Gly Phe Leu Glu  Lys Thr Lys 
    2240                 2245                 2250             


Lys Asp  Leu Gly Leu Gly Ser  Ile Ala Thr Gln Gln  Pro Glu Ser 
    2255                 2260                 2265             


Asn Ile  Leu Asp Ile Asp Leu  Arg Pro Ala Ser Ala  Trp Thr Leu 
    2270                 2275                 2280             


Tyr Ala  Val Ala Thr Thr Phe  Val Thr Pro Met Leu  Arg His Ser 
    2285                 2290                 2295             


Ile Glu  Asn Ser Ser Val Asn  Val Ser Leu Thr Ala  Ile Ala Asn 
    2300                 2305                 2310             


Gln Ala  Thr Val Leu Met Gly  Leu Gly Lys Gly Trp  Pro Leu Ser 
    2315                 2320                 2325             


Lys Met  Asp Ile Gly Val Pro  Leu Leu Ala Ile Gly  Cys Tyr Ser 
    2330                 2335                 2340             


Gln Val  Asn Pro Ile Thr Leu  Thr Ala Ala Leu Phe  Leu Leu Val 
    2345                 2350                 2355             


Ala His  Tyr Ala Ile Ile Gly  Pro Gly Leu Gln Ala  Lys Ala Thr 
    2360                 2365                 2370             


Arg Glu  Ala Gln Lys Arg Ala  Ala Ala Gly Ile Met  Lys Asn Pro 
    2375                 2380                 2385             


Thr Val  Asp Gly Ile Thr Val  Ile Asp Leu Asp Pro  Ile Pro Tyr 
    2390                 2395                 2400             


Asp Pro  Lys Phe Glu Lys Gln  Leu Gly Gln Val Met  Leu Leu Val 
    2405                 2410                 2415             


Leu Cys  Val Thr Gln Val Leu  Met Met Arg Thr Thr  Trp Ala Leu 
    2420                 2425                 2430             


Cys Glu  Ala Leu Thr Leu Ala  Thr Gly Pro Ile Ser  Thr Leu Trp 
    2435                 2440                 2445             


Glu Gly  Asn Pro Gly Arg Phe  Trp Asn Thr Thr Ile  Ala Val Ser 
    2450                 2455                 2460             


Met Ala  Asn Ile Phe Arg Gly  Ser Tyr Leu Ala Gly  Ala Gly Leu 
    2465                 2470                 2475             


Leu Phe  Ser Ile Met Lys Asn  Thr Thr Asn Thr Arg  Arg Gly Thr 
    2480                 2485                 2490             


Gly Asn  Ile Gly Glu Thr Leu  Gly Glu Lys Trp Lys  Ser Arg Leu 
    2495                 2500                 2505             


Asn Ala  Leu Gly Lys Ser Glu  Phe Gln Ile Tyr Lys  Lys Ser Gly 
    2510                 2515                 2520             


Ile Gln  Glu Val Asp Arg Thr  Leu Ala Lys Glu Gly  Ile Lys Arg 
    2525                 2530                 2535             


Gly Glu  Thr Asp His His Ala  Val Ser Arg Gly Ser  Ala Lys Leu 
    2540                 2545                 2550             


Arg Trp  Phe Val Glu Arg Asn  Met Val Thr Pro Glu  Gly Lys Val 
    2555                 2560                 2565             


Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp Ser Tyr  Tyr Cys Gly 
    2570                 2575                 2580             


Gly Leu  Lys Asn Val Arg Glu  Val Lys Gly Leu Thr  Lys Gly Gly 
    2585                 2590                 2595             


Pro Gly  His Glu Glu Pro Ile  Pro Met Ser Thr Tyr  Gly Trp Asn 
    2600                 2605                 2610             


Leu Val  Arg Leu Gln Ser Gly  Val Asp Val Phe Phe  Ile Pro Pro 
    2615                 2620                 2625             


Glu Lys  Cys Asp Thr Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Pro 
    2630                 2635                 2640             


Asn Pro  Thr Val Glu Ala Gly  Arg Thr Leu Arg Val  Leu Asn Leu 
    2645                 2650                 2655             


Val Glu  Asn Trp Leu Asn Asn  Asn Thr Gln Phe Cys  Ile Lys Val 
    2660                 2665                 2670             


Leu Asn  Pro Tyr Met Pro Ser  Val Ile Glu Lys Met  Glu Ala Leu 
    2675                 2680                 2685             


Gln Arg  Lys Tyr Gly Gly Ala  Leu Val Arg Asn Pro  Leu Ser Arg 
    2690                 2695                 2700             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Asn Ala  Ser Gly Asn 
    2705                 2710                 2715             


Ile Val  Ser Ser Val Asn Met  Ile Ser Arg Met Leu  Ile Asn Arg 
    2720                 2725                 2730             


Phe Thr  Met Arg Tyr Lys Lys  Ala Thr Tyr Glu Pro  Asp Val Asp 
    2735                 2740                 2745             


Leu Gly  Ser Gly Thr Arg Asn  Ile Gly Ile Glu Ser  Glu Ile Pro 
    2750                 2755                 2760             


Asn Leu  Asp Ile Ile Gly Lys  Arg Ile Glu Lys Ile  Lys Gln Glu 
    2765                 2770                 2775             


His Glu  Thr Ser Trp His Tyr  Asp Gln Asp His Pro  Tyr Lys Thr 
    2780                 2785                 2790             


Trp Ala  Tyr His Gly Ser Tyr  Glu Thr Lys Gln Thr  Gly Ser Ala 
    2795                 2800                 2805             


Ser Ser  Met Val Asn Gly Val  Val Arg Leu Leu Thr  Lys Pro Trp 
    2810                 2815                 2820             


Asp Val  Val Pro Met Val Thr  Gln Met Ala Met Thr  Asp Thr Thr 
    2825                 2830                 2835             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2840                 2845                 2850             


Thr Gln  Glu Pro Lys Glu Gly  Thr Lys Lys Leu Met  Lys Ile Thr 
    2855                 2860                 2865             


Ala Glu  Trp Leu Trp Lys Glu  Leu Gly Lys Lys Lys  Thr Pro Arg 
    2870                 2875                 2880             


Met Cys  Thr Arg Glu Glu Phe  Thr Arg Lys Val Arg  Ser Asn Ala 
    2885                 2890                 2895             


Ala Leu  Gly Ala Val Phe Thr  Asp Glu Asn Lys Trp  Lys Ser Ala 
    2900                 2905                 2910             


Arg Glu  Ala Val Glu Asp Ser  Arg Phe Trp Glu Leu  Val Asp Lys 
    2915                 2920                 2925             


Glu Arg  Asn Leu His Leu Glu  Gly Lys Cys Glu Thr  Cys Val Tyr 
    2930                 2935                 2940             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Leu Gly Glu  Phe Gly Lys 
    2945                 2950                 2955             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2960                 2965                 2970             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    2975                 2980                 2985             


Phe Ser  Arg Glu Asn Ser Leu  Ser Gly Val Glu Gly  Glu Gly Leu 
    2990                 2995                 3000             


His Lys  Leu Gly Tyr Ile Leu  Arg Asp Val Ser Lys  Lys Glu Gly 
    3005                 3010                 3015             


Gly Ala  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3020                 3025                 3030             


Thr Leu  Glu Asp Leu Lys Asn  Glu Glu Met Val Thr  Asn His Met 
    3035                 3040                 3045             


Glu Gly  Glu His Lys Lys Leu  Ala Glu Ala Ile Phe  Lys Leu Thr 
    3050                 3055                 3060             


Tyr Gln  Asn Lys Val Val Arg  Val Gln Arg Pro Thr  Pro Arg Gly 
    3065                 3070                 3075             


Thr Val  Met Asp Ile Ile Ser  Arg Arg Asp Gln Arg  Gly Ser Gly 
    3080                 3085                 3090             


Gln Val  Gly Thr Tyr Gly Leu  Asn Thr Phe Thr Asn  Met Glu Ala 
    3095                 3100                 3105             


Gln Leu  Ile Arg Gln Met Glu  Gly Glu Gly Val Phe  Lys Ser Ile 
    3110                 3115                 3120             


Gln His  Leu Thr Ile Thr Glu  Glu Ile Ala Val Gln  Asn Trp Leu 
    3125                 3130                 3135             


Ala Arg  Val Gly Arg Glu Arg  Leu Ser Arg Met Ala  Ile Ser Gly 
    3140                 3145                 3150             


Asp Asp  Cys Val Val Lys Pro  Leu Asp Asp Arg Phe  Ala Ser Ala 
    3155                 3160                 3165             


Leu Thr  Ala Leu Asn Asp Met  Gly Lys Ile Arg Lys  Asp Ile Gln 
    3170                 3175                 3180             


Gln Trp  Glu Pro Ser Arg Gly  Trp Asn Asp Trp Thr  Gln Val Pro 
    3185                 3190                 3195             


Phe Cys  Ser His His Phe His  Glu Leu Ile Met Lys  Asp Gly Arg 
    3200                 3205                 3210             


Val Leu  Val Val Pro Cys Arg  Asn Gln Asp Glu Leu  Ile Gly Arg 
    3215                 3220                 3225             


Ala Arg  Ile Ser Gln Gly Ala  Gly Trp Ser Leu Arg  Glu Thr Ala 
    3230                 3235                 3240             


Cys Leu  Gly Lys Ser Tyr Ala  Gln Met Trp Ser Leu  Met Tyr Phe 
    3245                 3250                 3255             


His Arg  Arg Asp Leu Arg Leu  Ala Ala Asn Ala Ile  Cys Ser Ala 
    3260                 3265                 3270             


Val Pro  Ser His Trp Val Pro  Thr Ser Arg Thr Thr  Trp Ser Ile 
    3275                 3280                 3285             


His Ala  Lys His Glu Trp Met  Thr Thr Glu Asp Met  Leu Thr Val 
    3290                 3295                 3300             


Trp Asn  Arg Val Trp Ile Gln  Glu Asn Pro Trp Met  Glu Asp Lys 
    3305                 3310                 3315             


Thr Pro  Val Glu Ser Trp Glu  Glu Ile Pro Tyr Leu  Gly Lys Arg 
    3320                 3325                 3330             


Glu Asp  Gln Trp Cys Gly Ser  Leu Ile Gly Leu Thr  Ser Arg Ala 
    3335                 3340                 3345             


Thr Trp  Ala Lys Asn Ile Gln  Ala Ala Ile Asn Gln  Val Arg Ser 
    3350                 3355                 3360             


Leu Ile  Gly Asn Glu Glu Tyr  Thr Asp Tyr Met Pro  Ser Met Lys 
    3365                 3370                 3375             


Arg Phe  Arg Arg Glu Glu Glu  Glu Ala Gly Val Leu  Trp 
    3380                 3385                 3390     


<210>  7
<211>  10717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 3, BVS

<400>  7
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gaccattaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagatctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acgcgtgatg gagagccgcg catgattgtg      480

gggaagaatg aaagaggaaa atccctactt ttcaagacag cctctggaat caacatgtgc      540

acactcatag ctatggatct gggagagatg tgtgatgaca cggtcactta caaatgcccc      600

cacattaccg aagtggagcc tgaagacatt gactgctggt gcaaccttac atcgacatgg      660

gtgacttatg gaacatgcaa tcaagctgga gagcatagac gcgataagag atcagtggcg      720

ttagctcccc atgttggcat gggactggac acacgcactc aaacctggat gtcggctgaa      780

ggagcttgga gacaagtcga gaaggtagag acatgggccc ttaggcaccc agggtttacc      840

atactagccc tatttcttgc ccattacata ggcacttcct tgacccagaa agtggttatt      900

tttatactat taatgctggt taccccatcc atgacaatga gatgtgtagg agtaggaaac      960

agagattttg tggaaggcct atcgggagct acgtgggttg acgtggtgct cgagcacggt     1020

gggtgtgtga ctaccatggc taagaacaag cccacgctgg acatagagct tcagaagacc     1080

gaggccaccc aactggcgac cctaaggaag ctatgcattg agggaaaaat taccaacata     1140

acaaccgact caagatgtcc cacccaaggg gaagcgattt tacctgagga gcaggaccag     1200

aactacgtgt gtaagcatac atacgtggac agaggctggg gaaacggttg tggtttgttt     1260

ggcaagggaa gcttggtgac atgcgcgaaa tttcaatgtt tagaatcaat agagggaaaa     1320

gtggtgcaac atgagaacct caaatacacc gtcatcatca cagtgcacac aggagaccaa     1380

caccaggtgg gaaatgaaac gcagggagtc acggctgaga taacacccca ggcatcaacc     1440

gctgaagcca ttttacctga atatggaacc ctcgggctag aatgctcacc acggacaggt     1500

ttggatttca atgaaatgat ctcattgaca atgaagaaca aagcatggat ggtacataga     1560

caatggttct ttgacttacc cctaccatgg acatcaggag cttcagcaga aacaccaact     1620

tggaacagga aagagcttct tgtgacattt aaaaatgcac atgcaaaaaa gcaagaagta     1680

gttgttcttg gatcacaaga gggagcaatg catacagcac tgacaggagc tacagagatc     1740

caaacctcag gaggcacaag tatctttgcg gggcacttaa aatgtagact caagatggac     1800

aaattggaac tcaaggggat gagctatgca atgtgcttga gtagctttgt gttgaagaaa     1860

gaagtctccg aaacgcagca tgggacaata ctcattaagg ttgagtacaa aggggaagat     1920

gcaccctgca agattccttt ctccacggag gatggacaag gaaaagctct caatggcaga     1980

ctgatcacag ccaatccagt ggtgaccaag aaggaggagc ctgtcaacat tgaggctgaa     2040

cctccttttg gagaaagtaa catagtaatt ggaattggag acaaagccct gaaaatcaac     2100

tggtacaaga agggaagctc gattgggaag atgttcgagg ccactgccag aggtgcaagg     2160

cgcatggcca tcttgggaga cacagcctgg gactttggat cagtgggtgg tgttttgaat     2220

tcattaggga aaatggtcca ccaaatattt gggagtgctt acacagccct atttggtgga     2280

gtctcctgga tgatgaaaat tggaataggt gtcctcttaa cctggatagg gttgaactca     2340

aaaaatactt ctatgtcatt ttcatgcatc gcggccggca ttgtgacact gtatttggga     2400

gtcatggtgc aggccgatag tggttgcgtt gtgagctgga aaaacaaaga actgaaatgt     2460

ggcagtggga ttttcatcac agacaacgtg cacacatgga cagaacaata caagttccaa     2520

ccagaatccc cttcaaaact agcttcagct atccagaaag cccatgaaga ggacatttgt     2580

ggaatccgct cagtaacaag actggagaat ctgatgtgga aacaaataac accagaattg     2640

aatcacattc tatcagaaaa tgaggtgaag ttaactatta tgacaggaga catcaaagga     2700

atcatgcagg caggaaaacg atctctgcgg cctcagccca ctgagctgaa gtattcatgg     2760

aaaacatggg gcaaagcaaa aatgctctct acagagtctc ataaccagac ctttctcatt     2820

gatggccccg aaacagcaga atgccccaac acaaatagag cttggaattc gttggaagtt     2880

gaagactatg gctttggagt attcaccacc aatatatggc taaaattgaa agaaaaacag     2940

gatgtattct gcgactcaaa actcatgtca gcggccataa aagacaacag agccgtccat     3000

gccgatatgg gttattggat agaaagtgca ctcaatgaca catggaagat agagaaagcc     3060

tctttcattg aagttaaaaa ctgccactgg ccaaaatcac acaccctctg gagcaatgga     3120

gtgctagaaa gtgagatgat aattccaaag aatctcgctg gaccagtgtc tcaacacaac     3180

tatagaccag gctaccatac acaaataaca ggaccatggc atctaggtaa gcttgagatg     3240

gactttgatt tctgtgatgg aacaacagtg gtagtgactg aggactgcgg aaatagagga     3300

ccctctttga gaacaaccac tgcctctgga aaactcataa cagaatggtg ctgccgatct     3360

tgcacattac caccgctaag atacagaggt gaggatgggt gctggtacgg gatggaaatc     3420

agaccattga aggagaaaga agagaatttg gtcaactcct tggtcacagc tggacatggg     3480

caggtcgaca acttttcact aggagtcttg ggaatggcat tgttcctgga ggaaatgctt     3540

aggacccgag taggaacgaa acatgcaata ctactagttg cagtttcttt tgtgacattg     3600

atcacaggga acatgtcctt tagagacctg ggaagagtga tggttatggt aggcgccact     3660

atgacggatg acataggtat gggcgtgact tatcttgccc tactagcagc cttcaaagtc     3720

agaccaactt ttgcagctgg actactcttg agaaagctga cctccaagga attgatgatg     3780

actactatag gaattgtact cctctcccag agcaccatac cagagaccat tcttgagttg     3840

actgatgcgt tagccttagg catgatggtc ctcaaaatgg tgagaaatat ggaaaagtat     3900

caattggcag tgactatcat ggctatcttg tgcgtcccaa acgcagtgat attacaaaac     3960

gcatggaaag tgagttgcac aatattggca gtggtgtccg tttccccact gttcttaaca     4020

tcctcacagc aaaaaacaga ttggatacca ttagcattga cgatcaaagg tctcaatcca     4080

acagctattt ttctaacaac cctctcaaga accagcaaga aaaggagctg gccattaaat     4140

gaggctatca tggcagtcgg gatggtgagc attttagcca gttctctcct aaaaaatgat     4200

attcccatga caggaccatt agtggctgga gggctcctca ctgtgtgcta cgtgctcact     4260

ggacgatcgg ccgatttgga actggagaga gcagccgatg tcaaatggga agaccaggca     4320

gagatatcag gaagcagtcc aatcctgtca ataacaatat cagaagatgg tagcatgtcg     4380

ataaaaaatg aagaggaaga acaaacactg accatactca ttagaacagg attgctggtg     4440

atctcaggac tttttcctgt atcaatacca atcacggcag cagcatggta cctgtgggaa     4500

gtgaagaaac aacgggccgg agtattgtgg gatgttcctt cacccccacc catgggaaag     4560

gctgaactgg aagatggagc ctatagaatt aagcaaaaag ggattcttgg atattcccag     4620

atcggagccg gagtttacaa agaaggaaca ttccatacaa tgtggcatgt cacacgtggc     4680

gctgttctaa tgcataaagg aaagaggatt gaaccatcat gggcggacgt caagaaagac     4740

ctaatatcat atggaggagg ctggaagtta gaaggagaat ggaaggaagg agaagaagtc     4800

caggtattgg cactggagcc tggaaaaaat ccaagagccg tccaaacgaa acctggtctt     4860

ttcaaaacca acgccggaac aataggtgct gtatctctgg acttttctcc tggaacgtca     4920

ggatctccaa ttatcgacaa aaaaggaaaa gttgtgggtc tttatggtaa tggtgttgtt     4980

acaaggagtg gagcatatgt gagtgctata gcccagactg aaaaaagcat tgaagacaac     5040

ccagagatcg aagatgacat tttccgaaag agaagactga ccatcatgga cctccaccca     5100

ggagcgggaa agacgaagag ataccttccg gccatagtca gagaagctat aaaacggggt     5160

ttgagaacat taatcttggc ccccactaga gttgtggcag ctgaaatgga ggaagccctt     5220

agaggacttc caataagata ccagacccca gccatcagag ctgtgcacac cgggcgggag     5280

attgtggacc taatgtgtca tgccacattt accatgaggc tgctatcacc agttagagtg     5340

ccaaactaca acctgattat catggacgaa gcccatttca cagacccagc aagtatagca     5400

gctagaggat acatctcaac tcgagtggag atgggtgagg cagctgggat ttttatgaca     5460

gccactcccc cgggaagcag agacccattt cctcagagca atgcaccaat catagatgaa     5520

gaaagagaaa tccctgaacg ctcgtggaat tccggacatg aatgggtcac ggattttaaa     5580

gggaagactg tttggttcgt tccaagtata aaagcaggaa atgatatagc agcttgcctg     5640

aggaaaaatg gaaagaaagt gatacaactc agtaggaaga cctttgattc tgagtatgtc     5700

aagactagaa ccaatgattg ggacttcgtg gttacaactg acatttcaga aatgggtgcc     5760

aatttcaagg ctgagagggt tatagacccc agacgctgca tgaaaccagt catactaaca     5820

gatggtgaag agcgggtgat tctggcagga cctatgccag tgacccactc tagtgcagca     5880

caaagaagag ggagaatagg aagaaatcca aaaaatgaga atgaccagta catatacatg     5940

ggggaacctc tggaaaatga tgaagactgt gcacactgga aagaagctaa aatgctccta     6000

gataacatca acacgccaga aggaatcatt cctagcatgt tcgaaccaga gcgtgaaaag     6060

gtggatgcca ttgatggcga ataccgcttg agaggagaag caaggaaaac ctttgtagac     6120

ttaatgagaa gaggagacct accagtctgg ttggcctaca gagtggcagc tgaaggcatc     6180

aactacgcag acagaaggtg gtgttttgat ggagtcaaga acaaccaaat cctagaagaa     6240

aacgtggaag ttgaaatctg gacaaaagaa ggggaaagga agaaattgaa acccagatgg     6300

ttggatgcta ggatctattc tgacccactg gcgctaaaag aatttaagga atttgcagcc     6360

ggaagaaagt ctctgaccct gaacctaatc acagaaatgg gtaggctccc aaccttcatg     6420

actcagaagg caagaaacgc actggacaac ttagcagtgc tgcacacggc tgaggcaggt     6480

ggaagggcgt acaaccatgc tctcagtgaa ctgccggaga ccctggagac attgctttta     6540

ctgacacttc tggctacagt cacgggaggg atctttttat tcttgatgag cgcaaggggc     6600

atagggaaga tgaccctggg aatgtgctgc ataatcacgg ctagcatcct cctatggtac     6660

gcacaaatac agccacactg gatagcagct tcaataatac tggagttttt tctcatagtt     6720

ttgcttattc cagaacctga aaaacagaga acaccccaag acaaccaact gacctacgtt     6780

gtcatagcca tcctcacagt ggtggccgca accatggcaa acgagatggg tttcctagaa     6840

aaaacgaaga aagatctcgg attgggaagc attgcaaccc agcaacccga gagcaacatc     6900

ctggacatag atctacgtcc tgcatcagca tggacgctgt atgccgtggc cacaacattt     6960

gttacaccaa tgttgagaca tagcattgaa aattcctcag tgaatgtgtc cctaacagct     7020

atagccaacc aagccacagt gttaatgggt ctcgggaaag gatggccatt gtcaaagatg     7080

gacatcggag ttccccttct cgccattgga tgctactcac aagtcaaccc cataactctc     7140

acagcagctc ttttcttatt ggtagcacat tatgccatca tagggccagg actccaagca     7200

aaagcaacca gagaagctca gaaaagagca gcggcgggca tcatgaaaaa cccaactgtc     7260

gatggaataa cagtgattga cctagatcca ataccttatg atccaaagtt tgaaaagcag     7320

ttgggacaag taatgctcct agtcctctgc gtgactcaag tattgatgat gaggactaca     7380

tgggctctgt gtgaggcttt aaccttagct accgggccca tctccacatt gtgggaagga     7440

aatccaggga ggttttggaa cactaccatt gcggtgtcaa tggctaacat ttttagaggg     7500

agttacttgg ccggagctgg acttctcttt tctattatga agaacacaac caacacaaga     7560

aggggaactg gcaacatagg agagacgctt ggagagaaat ggaaaagccg attgaacgcg     7620

ttgggaaaaa gtgaattcca gatctacaag aaaagtggaa tccaggaagt ggatagaacc     7680

ttagcaaaag aaggcattaa aagaggagaa acggaccatc acgctgtgtc gcgaggctca     7740

gcaaaactga gatggttcgt tgagagaaac atggtcacac cagaagggaa agtagtggac     7800

ctcggttgtg gcagaggagg ctggtcatac tattgtggag gactaaagaa tgtaagagaa     7860

gtcaaaggcc taacaaaagg aggaccagga cacgaagaac ccatccccat gtcaacatat     7920

gggtggaatc tagtgcgtct tcaaagtgga gttgacgttt tcttcatccc gccagaaaag     7980

tgtgacacat tattgtgtga cataggggag tcatcaccaa atcccacagt ggaagcagga     8040

cgaacactca gagtccttaa cttagtagaa aattggttga acaacaacac tcaattttgc     8100

ataaaggttc tcaacccata tatgccctca gtcatagaaa aaatggaagc actacaaagg     8160

aaatatggag gagccttagt gaggaatcca ctctcacgaa actccacaca tgagatgtac     8220

tgggtatcca atgcttccgg gaacatagtg tcatcagtga acatgatttc aaggatgttg     8280

atcaacagat ttacaatgag atacaagaaa gccacttacg agccggatgt tgacctcgga     8340

agcggaaccc gtaacatcgg gattgaaagt gagataccaa acctagatat aattgggaaa     8400

agaatagaaa aaataaagca agagcatgaa acatcatggc actatgacca agaccaccca     8460

tacaaaacgt gggcatacca tggtagctat gaaacaaaac agactggatc agcatcatcc     8520

atggtcaacg gagtggtcag gctgctgaca aaaccttggg acgtcgtccc catggtgaca     8580

cagatggcaa tgacagacac gactccattt ggacaacagc gcgtttttaa agagaaagtg     8640

gacacgagaa cccaagaacc gaaagaaggc acgaagaaac taatgaaaat aacagcagag     8700

tggctttgga aagaattagg gaagaaaaag acacccagga tgtgcaccag agaagaattc     8760

acaagaaagg tgagaagcaa tgcagccttg ggggccatat tcactgatga gaacaagtgg     8820

aagtcggcac gtgaggctgt tgaagatagt aggttttggg agctggttga caaggaaagg     8880

aatctccatc ttgaaggaaa gtgtgaaaca tgtgtgtaca acatgatggg aaaaagagag     8940

aagaagctag gggaattcgg caaggcaaaa ggcagcagag ccatatggta catgtggctt     9000

ggagcacgct tcttagagtt tgaagcccta ggattcttaa atgaagatca ctggttctcc     9060

agagagaact ccctgagtgg agtggaagga gaagggctgc acaagctagg ttacattcta     9120

agagacgtga gcaagaaaga gggaggagca atgtatgccg atgacaccgc aggatgggat     9180

acaagaatca cactagaaga cctaaaaaat gaagaaatgg taacaaacca catggaagga     9240

gaacacaaga aactagccga ggccattttc aaactaacgt accaaaacaa ggtggtgcgt     9300

gtgcaaagac caacaccaag aggcacagta atggacatca tatcgagaag agaccaaaga     9360

ggtagtggac aagttggcac ctatggactc aatactttca ccaatatgga agcccaacta     9420

atcagacaga tggagggaga aggagtcttt aaaagcattc agcacctaac aatcacagaa     9480

gaaatcgctg tgcaaaactg gttagcaaga gtggggcgcg aaaggttatc aagaatggcc     9540

atcagtggag atgattgtgt tgtgaaacct ttagatgaca ggttcgcaag cgctttaaca     9600

gctctaaatg acatgggaaa gattaggaaa gacatacaac aatgggaacc ttcaagagga     9660

tggaatgatt ggacacaagt gcccttctgt tcacaccatt tccatgagtt aatcatgaaa     9720

gacggtcgcg tactcgttgt tccatgtaga aaccaagatg aactgattgg cagagcccga     9780

atctcccaag gagcagggtg gtctttgcgg gagacggcct gtttggggaa gtcttacgcc     9840

caaatgtgga gcttgatgta cttccacaga cgcgacctca ggctggcggc aaatgctatt     9900

tgctcggcag taccatcaca ttgggttcca acaagtcgaa caacctggtc catacatgct     9960

aaacatgaat ggatgacaac ggaagacatg ctgacagtct ggaacagggt gtggattcaa    10020

gaaaacccat ggatggaaga caaaactcca gtggaatcat gggaggaaat cccatacttg    10080

gggaaaagag aagaccaatg gtgcggctca ttgattgggt taacaagcag ggccacctgg    10140

gcaaagaaca tccaagcagc aataaatcaa gttagatccc ttataggcaa tgaagaatac    10200

acagattaca tgccatccat gaaaagattc agaagagaag aggaagaagc aggagttctg    10260

tggtagaaag caaaactaac atgaaacaag gctagaagtc aggtcggatt aagccatagt    10320

acggaaaaaa ctatgctacc tgtgagcccc gtccaaggac gttaaaagaa gtcaggccat    10380

cataaatgcc atagcttgag taaactatgc agcctgtagc tccacctgag aaggtgtaaa    10440

aaatccggga ggccacaaac catggaagct gtacgcatgg cgtagtggac tagcggttag    10500

aggagacccc tcccttacaa atcgcagcaa caatgggggc ccaaggcgag atgaagctgt    10560

agtctcgctg gaaggactag aggttagagg agaccccccc gaaacaaaaa acagcatatt    10620

gacgctggga aagaccagag atcctgctgt ctcctcagca tcattccagg cacagaacgc    10680

cagaaaatgg aatggtgctg ttgaatcaac aggttct                             10717


<210>  8
<211>  3389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 3, BVS

<400>  8

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Asp Gly Glu Pro Arg Met Ile Val 
        115                 120                 125             


Gly Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ala Ser Gly 
    130                 135                 140                 


Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Asp 
145                 150                 155                 160 


Asp Thr Val Thr Tyr Lys Cys Pro His Ile Thr Glu Val Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr Gln Thr Trp 
    210                 215                 220                 


Met Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val Glu Thr Trp 
225                 230                 235                 240 


Ala Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe Leu Ala His 
                245                 250                 255     


Tyr Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe Ile Leu Leu 
            260                 265                 270         


Met Leu Val Thr Pro Ser Met Thr Met Arg Cys Val Gly Val Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 
    290                 295                 300                 


Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu Ala Thr Leu 
                325                 330                 335     


Arg Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr Thr Asp Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro Glu Glu Gln Asp Gln 
        355                 360                 365             


Asn Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Gln 
385                 390                 395                 400 


Cys Leu Glu Ser Ile Glu Gly Lys Val Val Gln His Glu Asn Leu Lys 
                405                 410                 415     


Tyr Thr Val Ile Ile Thr Val His Thr Gly Asp Gln His Gln Val Gly 
            420                 425                 430         


Asn Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln Ala Ser Thr 
        435                 440                 445             


Ala Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu Glu Cys Ser 
    450                 455                 460                 


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Ser Leu Thr Met Lys 
465                 470                 475                 480 


Asn Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp Leu Pro Leu 
                485                 490                 495     


Pro Trp Thr Ser Gly Ala Ser Ala Glu Thr Pro Thr Trp Asn Arg Lys 
            500                 505                 510         


Glu Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys Gln Glu Val 
        515                 520                 525             


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
    530                 535                 540                 


Ala Thr Glu Ile Gln Thr Ser Gly Gly Thr Ser Ile Phe Ala Gly His 
545                 550                 555                 560 


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys Gly Met Ser 
                565                 570                 575     


Tyr Ala Met Cys Leu Ser Ser Phe Val Leu Lys Lys Glu Val Ser Glu 
            580                 585                 590         


Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys Gly Glu Asp 
        595                 600                 605             


Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln Gly Lys Ala 
    610                 615                 620                 


Leu Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Lys Lys Glu 
625                 630                 635                 640 


Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Asn Ile 
                645                 650                 655     


Val Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp Tyr Lys Lys 
            660                 665                 670         


Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala Arg 
        675                 680                 685             


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly 
    690                 695                 700                 


Gly Val Leu Asn Ser Leu Gly Lys Met Val His Gln Ile Phe Gly Ser 
705                 710                 715                 720 


Ala Tyr Thr Ala Leu Phe Gly Gly Val Ser Trp Met Met Lys Ile Gly 
                725                 730                 735     


Ile Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr Ser 
            740                 745                 750         


Met Ser Phe Ser Cys Ile Ala Ala Gly Ile Val Thr Leu Tyr Leu Gly 
        755                 760                 765             


Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys Asn Lys 
    770                 775                 780                 


Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val His Thr 
785                 790                 795                 800 


Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys Leu Ala 
                805                 810                 815     


Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile Arg Ser 
            820                 825                 830         


Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro Glu Leu 
        835                 840                 845             


Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met Thr Gly 
    850                 855                 860                 


Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg Pro Gln 
865                 870                 875                 880 


Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Met 
                885                 890                 895     


Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly Pro Glu 
            900                 905                 910         


Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu Glu Val 
        915                 920                 925             


Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu 
    930                 935                 940                 


Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser Ala Ala 
945                 950                 955                 960 


Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu 
                965                 970                 975     


Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe Ile Glu 
            980                 985                 990         


Val Lys Asn Cys His Trp Pro Lys  Ser His Thr Leu Trp  Ser Asn Gly 
        995                 1000                 1005             


Val Leu  Glu Ser Glu Met Ile  Ile Pro Lys Asn Leu  Ala Gly Pro 
    1010                 1015                 1020             


Val Ser  Gln His Asn Tyr Arg  Pro Gly Tyr His Thr  Gln Ile Thr 
    1025                 1030                 1035             


Gly Pro  Trp His Leu Gly Lys  Leu Glu Met Asp Phe  Asp Phe Cys 
    1040                 1045                 1050             


Asp Gly  Thr Thr Val Val Val  Thr Glu Asp Cys Gly  Asn Arg Gly 
    1055                 1060                 1065             


Pro Ser  Leu Arg Thr Thr Thr  Ala Ser Gly Lys Leu  Ile Thr Glu 
    1070                 1075                 1080             


Trp Cys  Cys Arg Ser Cys Thr  Leu Pro Pro Leu Arg  Tyr Arg Gly 
    1085                 1090                 1095             


Glu Asp  Gly Cys Trp Tyr Gly  Met Glu Ile Arg Pro  Leu Lys Glu 
    1100                 1105                 1110             


Lys Glu  Glu Asn Leu Val Asn  Ser Leu Val Thr Ala  Gly His Gly 
    1115                 1120                 1125             


Gln Val  Asp Asn Phe Ser Leu  Gly Val Leu Gly Met  Ala Leu Phe 
    1130                 1135                 1140             


Leu Glu  Glu Met Leu Arg Thr  Arg Val Gly Thr Lys  His Ala Ile 
    1145                 1150                 1155             


Leu Leu  Val Ala Val Ser Phe  Val Thr Leu Ile Thr  Gly Asn Met 
    1160                 1165                 1170             


Ser Phe  Arg Asp Leu Gly Arg  Val Met Val Met Val  Gly Ala Thr 
    1175                 1180                 1185             


Met Thr  Asp Asp Ile Gly Met  Gly Val Thr Tyr Leu  Ala Leu Leu 
    1190                 1195                 1200             


Ala Ala  Phe Lys Val Arg Pro  Thr Phe Ala Ala Gly  Leu Leu Leu 
    1205                 1210                 1215             


Arg Lys  Leu Thr Ser Lys Glu  Leu Met Met Thr Thr  Ile Gly Ile 
    1220                 1225                 1230             


Val Leu  Leu Ser Gln Ser Thr  Ile Pro Glu Thr Ile  Leu Glu Leu 
    1235                 1240                 1245             


Thr Asp  Ala Leu Ala Leu Gly  Met Met Val Leu Lys  Met Val Arg 
    1250                 1255                 1260             


Asn Met  Glu Lys Tyr Gln Leu  Ala Val Thr Ile Met  Ala Ile Leu 
    1265                 1270                 1275             


Cys Val  Pro Asn Ala Val Ile  Leu Gln Asn Ala Trp  Lys Val Ser 
    1280                 1285                 1290             


Cys Thr  Ile Leu Ala Val Val  Ser Val Ser Pro Leu  Phe Leu Thr 
    1295                 1300                 1305             


Ser Ser  Gln Gln Lys Thr Asp  Trp Ile Pro Leu Ala  Leu Thr Ile 
    1310                 1315                 1320             


Lys Gly  Leu Asn Pro Thr Ala  Ile Phe Leu Thr Thr  Leu Ser Arg 
    1325                 1330                 1335             


Thr Ser  Lys Lys Arg Ser Trp  Pro Leu Asn Glu Ala  Ile Met Ala 
    1340                 1345                 1350             


Val Gly  Met Val Ser Ile Leu  Ala Ser Ser Leu Leu  Lys Asn Asp 
    1355                 1360                 1365             


Ile Pro  Met Thr Gly Pro Leu  Val Ala Gly Gly Leu  Leu Thr Val 
    1370                 1375                 1380             


Cys Tyr  Val Leu Thr Gly Arg  Ser Ala Asp Leu Glu  Leu Glu Arg 
    1385                 1390                 1395             


Ala Ala  Asp Val Lys Trp Glu  Asp Gln Ala Glu Ile  Ser Gly Ser 
    1400                 1405                 1410             


Ser Pro  Ile Leu Ser Ile Thr  Ile Ser Glu Asp Gly  Ser Met Ser 
    1415                 1420                 1425             


Ile Lys  Asn Glu Glu Glu Glu  Gln Thr Leu Thr Ile  Leu Ile Arg 
    1430                 1435                 1440             


Thr Gly  Leu Leu Val Ile Ser  Gly Leu Phe Pro Val  Ser Ile Pro 
    1445                 1450                 1455             


Ile Thr  Ala Ala Ala Trp Tyr  Leu Trp Glu Val Lys  Lys Gln Arg 
    1460                 1465                 1470             


Ala Gly  Val Leu Trp Asp Val  Pro Ser Pro Pro Pro  Met Gly Lys 
    1475                 1480                 1485             


Ala Glu  Leu Glu Asp Gly Ala  Tyr Arg Ile Lys Gln  Lys Gly Ile 
    1490                 1495                 1500             


Leu Gly  Tyr Ser Gln Ile Gly  Ala Gly Val Tyr Lys  Glu Gly Thr 
    1505                 1510                 1515             


Phe His  Thr Met Trp His Val  Thr Arg Gly Ala Val  Leu Met His 
    1520                 1525                 1530             


Lys Gly  Lys Arg Ile Glu Pro  Ser Trp Ala Asp Val  Lys Lys Asp 
    1535                 1540                 1545             


Leu Ile  Ser Tyr Gly Gly Gly  Trp Lys Leu Glu Gly  Glu Trp Lys 
    1550                 1555                 1560             


Glu Gly  Glu Glu Val Gln Val  Leu Ala Leu Glu Pro  Gly Lys Asn 
    1565                 1570                 1575             


Pro Arg  Ala Val Gln Thr Lys  Pro Gly Leu Phe Lys  Thr Asn Ala 
    1580                 1585                 1590             


Gly Thr  Ile Gly Ala Val Ser  Leu Asp Phe Ser Pro  Gly Thr Ser 
    1595                 1600                 1605             


Gly Ser  Pro Ile Ile Asp Lys  Lys Gly Lys Val Val  Gly Leu Tyr 
    1610                 1615                 1620             


Gly Asn  Gly Val Val Thr Arg  Ser Gly Ala Tyr Val  Ser Ala Ile 
    1625                 1630                 1635             


Ala Gln  Thr Glu Lys Ser Ile  Glu Asp Asn Pro Glu  Ile Glu Asp 
    1640                 1645                 1650             


Asp Ile  Phe Arg Lys Arg Arg  Leu Thr Ile Met Asp  Leu His Pro 
    1655                 1660                 1665             


Gly Ala  Gly Lys Thr Lys Arg  Tyr Leu Pro Ala Ile  Val Arg Glu 
    1670                 1675                 1680             


Ala Ile  Lys Arg Gly Leu Arg  Thr Leu Ile Leu Ala  Pro Thr Arg 
    1685                 1690                 1695             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Ile 
    1700                 1705                 1710             


Arg Tyr  Gln Thr Pro Ala Ile  Arg Ala Val His Thr  Gly Arg Glu 
    1715                 1720                 1725             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Met  Arg Leu Leu 
    1730                 1735                 1740             


Ser Pro  Val Arg Val Pro Asn  Tyr Asn Leu Ile Ile  Met Asp Glu 
    1745                 1750                 1755             


Ala His  Phe Thr Asp Pro Ala  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1760                 1765                 1770             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Gly Ile  Phe Met Thr 
    1775                 1780                 1785             


Ala Thr  Pro Pro Gly Ser Arg  Asp Pro Phe Pro Gln  Ser Asn Ala 
    1790                 1795                 1800             


Pro Ile  Ile Asp Glu Glu Arg  Glu Ile Pro Glu Arg  Ser Trp Asn 
    1805                 1810                 1815             


Ser Gly  His Glu Trp Val Thr  Asp Phe Lys Gly Lys  Thr Val Trp 
    1820                 1825                 1830             


Phe Val  Pro Ser Ile Lys Ala  Gly Asn Asp Ile Ala  Ala Cys Leu 
    1835                 1840                 1845             


Arg Lys  Asn Gly Lys Lys Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1850                 1855                 1860             


Asp Ser  Glu Tyr Val Lys Thr  Arg Thr Asn Asp Trp  Asp Phe Val 
    1865                 1870                 1875             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Glu 
    1880                 1885                 1890             


Arg Val  Ile Asp Pro Arg Arg  Cys Met Lys Pro Val  Ile Leu Thr 
    1895                 1900                 1905             


Asp Gly  Glu Glu Arg Val Ile  Leu Ala Gly Pro Met  Pro Val Thr 
    1910                 1915                 1920             


His Ser  Ser Ala Ala Gln Arg  Arg Gly Arg Ile Gly  Arg Asn Pro 
    1925                 1930                 1935             


Lys Asn  Glu Asn Asp Gln Tyr  Ile Tyr Met Gly Glu  Pro Leu Glu 
    1940                 1945                 1950             


Asn Asp  Glu Asp Cys Ala His  Trp Lys Glu Ala Lys  Met Leu Leu 
    1955                 1960                 1965             


Asp Asn  Ile Asn Thr Pro Glu  Gly Ile Ile Pro Ser  Met Phe Glu 
    1970                 1975                 1980             


Pro Glu  Arg Glu Lys Val Asp  Ala Ile Asp Gly Glu  Tyr Arg Leu 
    1985                 1990                 1995             


Arg Gly  Glu Ala Arg Lys Thr  Phe Val Asp Leu Met  Arg Arg Gly 
    2000                 2005                 2010             


Asp Leu  Pro Val Trp Leu Ala  Tyr Arg Val Ala Ala  Glu Gly Ile 
    2015                 2020                 2025             


Asn Tyr  Ala Asp Arg Arg Trp  Cys Phe Asp Gly Val  Lys Asn Asn 
    2030                 2035                 2040             


Gln Ile  Leu Glu Glu Asn Val  Glu Val Glu Ile Trp  Thr Lys Glu 
    2045                 2050                 2055             


Gly Glu  Arg Lys Lys Leu Lys  Pro Arg Trp Leu Asp  Ala Arg Ile 
    2060                 2065                 2070             


Tyr Ser  Asp Pro Leu Ala Leu  Lys Glu Phe Lys Glu  Phe Ala Ala 
    2075                 2080                 2085             


Gly Arg  Lys Ser Leu Thr Leu  Asn Leu Ile Thr Glu  Met Gly Arg 
    2090                 2095                 2100             


Leu Pro  Thr Phe Met Thr Gln  Lys Ala Arg Asn Ala  Leu Asp Asn 
    2105                 2110                 2115             


Leu Ala  Val Leu His Thr Ala  Glu Ala Gly Gly Arg  Ala Tyr Asn 
    2120                 2125                 2130             


His Ala  Leu Ser Glu Leu Pro  Glu Thr Leu Glu Thr  Leu Leu Leu 
    2135                 2140                 2145             


Leu Thr  Leu Leu Ala Thr Val  Thr Gly Gly Ile Phe  Leu Phe Leu 
    2150                 2155                 2160             


Met Ser  Ala Arg Gly Ile Gly  Lys Met Thr Leu Gly  Met Cys Cys 
    2165                 2170                 2175             


Ile Ile  Thr Ala Ser Ile Leu  Leu Trp Tyr Ala Gln  Ile Gln Pro 
    2180                 2185                 2190             


His Trp  Ile Ala Ala Ser Ile  Ile Leu Glu Phe Phe  Leu Ile Val 
    2195                 2200                 2205             


Leu Leu  Ile Pro Glu Pro Glu  Lys Gln Arg Thr Pro  Gln Asp Asn 
    2210                 2215                 2220             


Gln Leu  Thr Tyr Val Val Ile  Ala Ile Leu Thr Val  Val Ala Ala 
    2225                 2230                 2235             


Thr Met  Ala Asn Glu Met Gly  Phe Leu Glu Lys Thr  Lys Lys Asp 
    2240                 2245                 2250             


Leu Gly  Leu Gly Ser Ile Ala  Thr Gln Gln Pro Glu  Ser Asn Ile 
    2255                 2260                 2265             


Leu Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Thr  Leu Tyr Ala 
    2270                 2275                 2280             


Val Ala  Thr Thr Phe Val Thr  Pro Met Leu Arg His  Ser Ile Glu 
    2285                 2290                 2295             


Asn Ser  Ser Val Asn Val Ser  Leu Thr Ala Ile Ala  Asn Gln Ala 
    2300                 2305                 2310             


Thr Val  Leu Met Gly Leu Gly  Lys Gly Trp Pro Leu  Ser Lys Met 
    2315                 2320                 2325             


Asp Ile  Gly Val Pro Leu Leu  Ala Ile Gly Cys Tyr  Ser Gln Val 
    2330                 2335                 2340             


Asn Pro  Ile Thr Leu Thr Ala  Ala Leu Phe Leu Leu  Val Ala His 
    2345                 2350                 2355             


Tyr Ala  Ile Ile Gly Pro Gly  Leu Gln Ala Lys Ala  Thr Arg Glu 
    2360                 2365                 2370             


Ala Gln  Lys Arg Ala Ala Ala  Gly Ile Met Lys Asn  Pro Thr Val 
    2375                 2380                 2385             


Asp Gly  Ile Thr Val Ile Asp  Leu Asp Pro Ile Pro  Tyr Asp Pro 
    2390                 2395                 2400             


Lys Phe  Glu Lys Gln Leu Gly  Gln Val Met Leu Leu  Val Leu Cys 
    2405                 2410                 2415             


Val Thr  Gln Val Leu Met Met  Arg Thr Thr Trp Ala  Leu Cys Glu 
    2420                 2425                 2430             


Ala Leu  Thr Leu Ala Thr Gly  Pro Ile Ser Thr Leu  Trp Glu Gly 
    2435                 2440                 2445             


Asn Pro  Gly Arg Phe Trp Asn  Thr Thr Ile Ala Val  Ser Met Ala 
    2450                 2455                 2460             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Gly  Leu Leu Phe 
    2465                 2470                 2475             


Ser Ile  Met Lys Asn Thr Thr  Asn Thr Arg Arg Gly  Thr Gly Asn 
    2480                 2485                 2490             


Ile Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ser Arg  Leu Asn Ala 
    2495                 2500                 2505             


Leu Gly  Lys Ser Glu Phe Gln  Ile Tyr Lys Lys Ser  Gly Ile Gln 
    2510                 2515                 2520             


Glu Val  Asp Arg Thr Leu Ala  Lys Glu Gly Ile Lys  Arg Gly Glu 
    2525                 2530                 2535             


Thr Asp  His His Ala Val Ser  Arg Gly Ser Ala Lys  Leu Arg Trp 
    2540                 2545                 2550             


Phe Val  Glu Arg Asn Met Val  Thr Pro Glu Gly Lys  Val Val Asp 
    2555                 2560                 2565             


Leu Gly  Cys Gly Arg Gly Gly  Trp Ser Tyr Tyr Cys  Gly Gly Leu 
    2570                 2575                 2580             


Lys Asn  Val Arg Glu Val Lys  Gly Leu Thr Lys Gly  Gly Pro Gly 
    2585                 2590                 2595             


His Glu  Glu Pro Ile Pro Met  Ser Thr Tyr Gly Trp  Asn Leu Val 
    2600                 2605                 2610             


Arg Leu  Gln Ser Gly Val Asp  Val Phe Phe Ile Pro  Pro Glu Lys 
    2615                 2620                 2625             


Cys Asp  Thr Leu Leu Cys Asp  Ile Gly Glu Ser Ser  Pro Asn Pro 
    2630                 2635                 2640             


Thr Val  Glu Ala Gly Arg Thr  Leu Arg Val Leu Asn  Leu Val Glu 
    2645                 2650                 2655             


Asn Trp  Leu Asn Asn Asn Thr  Gln Phe Cys Ile Lys  Val Leu Asn 
    2660                 2665                 2670             


Pro Tyr  Met Pro Ser Val Ile  Glu Lys Met Glu Ala  Leu Gln Arg 
    2675                 2680                 2685             


Lys Tyr  Gly Gly Ala Leu Val  Arg Asn Pro Leu Ser  Arg Asn Ser 
    2690                 2695                 2700             


Thr His  Glu Met Tyr Trp Val  Ser Asn Ala Ser Gly  Asn Ile Val 
    2705                 2710                 2715             


Ser Ser  Val Asn Met Ile Ser  Arg Met Leu Ile Asn  Arg Phe Thr 
    2720                 2725                 2730             


Met Arg  Tyr Lys Lys Ala Thr  Tyr Glu Pro Asp Val  Asp Leu Gly 
    2735                 2740                 2745             


Ser Gly  Thr Arg Asn Ile Gly  Ile Glu Ser Glu Ile  Pro Asn Leu 
    2750                 2755                 2760             


Asp Ile  Ile Gly Lys Arg Ile  Glu Lys Ile Lys Gln  Glu His Glu 
    2765                 2770                 2775             


Thr Ser  Trp His Tyr Asp Gln  Asp His Pro Tyr Lys  Thr Trp Ala 
    2780                 2785                 2790             


Tyr His  Gly Ser Tyr Glu Thr  Lys Gln Thr Gly Ser  Ala Ser Ser 
    2795                 2800                 2805             


Met Val  Asn Gly Val Val Arg  Leu Leu Thr Lys Pro  Trp Asp Val 
    2810                 2815                 2820             


Val Pro  Met Val Thr Gln Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2825                 2830                 2835             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Arg Thr Gln 
    2840                 2845                 2850             


Glu Pro  Lys Glu Gly Thr Lys  Lys Leu Met Lys Ile  Thr Ala Glu 
    2855                 2860                 2865             


Trp Leu  Trp Lys Glu Leu Gly  Lys Lys Lys Thr Pro  Arg Met Cys 
    2870                 2875                 2880             


Thr Arg  Glu Glu Phe Thr Arg  Lys Val Arg Ser Asn  Ala Ala Leu 
    2885                 2890                 2895             


Gly Ala  Ile Phe Thr Asp Glu  Asn Lys Trp Lys Ser  Ala Arg Glu 
    2900                 2905                 2910             


Ala Val  Glu Asp Ser Arg Phe  Trp Glu Leu Val Asp  Lys Glu Arg 
    2915                 2920                 2925             


Asn Leu  His Leu Glu Gly Lys  Cys Glu Thr Cys Val  Tyr Asn Met 
    2930                 2935                 2940             


Met Gly  Lys Arg Glu Lys Lys  Leu Gly Glu Phe Gly  Lys Ala Lys 
    2945                 2950                 2955             


Gly Ser  Arg Ala Ile Trp Tyr  Met Trp Leu Gly Ala  Arg Phe Leu 
    2960                 2965                 2970             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Phe Ser 
    2975                 2980                 2985             


Arg Glu  Asn Ser Leu Ser Gly  Val Glu Gly Glu Gly  Leu His Lys 
    2990                 2995                 3000             


Leu Gly  Tyr Ile Leu Arg Asp  Val Ser Lys Lys Glu  Gly Gly Ala 
    3005                 3010                 3015             


Met Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Leu 
    3020                 3025                 3030             


Glu Asp  Leu Lys Asn Glu Glu  Met Val Thr Asn His  Met Glu Gly 
    3035                 3040                 3045             


Glu His  Lys Lys Leu Ala Glu  Ala Ile Phe Lys Leu  Thr Tyr Gln 
    3050                 3055                 3060             


Asn Lys  Val Val Arg Val Gln  Arg Pro Thr Pro Arg  Gly Thr Val 
    3065                 3070                 3075             


Met Asp  Ile Ile Ser Arg Arg  Asp Gln Arg Gly Ser  Gly Gln Val 
    3080                 3085                 3090             


Gly Thr  Tyr Gly Leu Asn Thr  Phe Thr Asn Met Glu  Ala Gln Leu 
    3095                 3100                 3105             


Ile Arg  Gln Met Glu Gly Glu  Gly Val Phe Lys Ser  Ile Gln His 
    3110                 3115                 3120             


Leu Thr  Ile Thr Glu Glu Ile  Ala Val Gln Asn Trp  Leu Ala Arg 
    3125                 3130                 3135             


Val Gly  Arg Glu Arg Leu Ser  Arg Met Ala Ile Ser  Gly Asp Asp 
    3140                 3145                 3150             


Cys Val  Val Lys Pro Leu Asp  Asp Arg Phe Ala Ser  Ala Leu Thr 
    3155                 3160                 3165             


Ala Leu  Asn Asp Met Gly Lys  Ile Arg Lys Asp Ile  Gln Gln Trp 
    3170                 3175                 3180             


Glu Pro  Ser Arg Gly Trp Asn  Asp Trp Thr Gln Val  Pro Phe Cys 
    3185                 3190                 3195             


Ser His  His Phe His Glu Leu  Ile Met Lys Asp Gly  Arg Val Leu 
    3200                 3205                 3210             


Val Val  Pro Cys Arg Asn Gln  Asp Glu Leu Ile Gly  Arg Ala Arg 
    3215                 3220                 3225             


Ile Ser  Gln Gly Ala Gly Trp  Ser Leu Arg Glu Thr  Ala Cys Leu 
    3230                 3235                 3240             


Gly Lys  Ser Tyr Ala Gln Met  Trp Ser Leu Met Tyr  Phe His Arg 
    3245                 3250                 3255             


Arg Asp  Leu Arg Leu Ala Ala  Asn Ala Ile Cys Ser  Ala Val Pro 
    3260                 3265                 3270             


Ser His  Trp Val Pro Thr Ser  Arg Thr Thr Trp Ser  Ile His Ala 
    3275                 3280                 3285             


Lys His  Glu Trp Met Thr Thr  Glu Asp Met Leu Thr  Val Trp Asn 
    3290                 3295                 3300             


Arg Val  Trp Ile Gln Glu Asn  Pro Trp Met Glu Asp  Lys Thr Pro 
    3305                 3310                 3315             


Val Glu  Ser Trp Glu Glu Ile  Pro Tyr Leu Gly Lys  Arg Glu Asp 
    3320                 3325                 3330             


Gln Trp  Cys Gly Ser Leu Ile  Gly Leu Thr Ser Arg  Ala Thr Trp 
    3335                 3340                 3345             


Ala Lys  Asn Ile Gln Ala Ala  Ile Asn Gln Val Arg  Ser Leu Ile 
    3350                 3355                 3360             


Gly Asn  Glu Glu Tyr Thr Asp  Tyr Met Pro Ser Met  Lys Arg Phe 
    3365                 3370                 3375             


Arg Arg  Glu Glu Glu Glu Ala  Gly Val Leu Trp 
    3380                 3385                 


<210>  9
<211>  3389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 3, MVS

<400>  9

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Asp Gly Glu Pro Arg Met Ile Val 
        115                 120                 125             


Gly Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ala Ser Gly 
    130                 135                 140                 


Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Asp 
145                 150                 155                 160 


Asp Thr Val Thr Tyr Lys Cys Pro His Ile Thr Glu Val Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr Gln Thr Trp 
    210                 215                 220                 


Met Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val Glu Thr Trp 
225                 230                 235                 240 


Ala Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe Leu Ala His 
                245                 250                 255     


Tyr Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe Ile Leu Leu 
            260                 265                 270         


Met Leu Val Thr Pro Ser Met Thr Met Arg Cys Val Gly Val Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 
    290                 295                 300                 


Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu Ala Thr Leu 
                325                 330                 335     


Arg Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr Thr Asp Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro Glu Glu Gln Asp Gln 
        355                 360                 365             


Asn Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Gln 
385                 390                 395                 400 


Cys Leu Glu Ser Ile Glu Gly Lys Val Val Gln His Glu Asn Leu Lys 
                405                 410                 415     


Tyr Thr Val Ile Ile Thr Val His Thr Gly Asp Gln His Gln Val Gly 
            420                 425                 430         


Asn Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln Ala Ser Thr 
        435                 440                 445             


Ala Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu Glu Cys Ser 
    450                 455                 460                 


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Ser Leu Thr Met Lys 
465                 470                 475                 480 


Asn Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp Leu Pro Leu 
                485                 490                 495     


Pro Trp Thr Ser Gly Ala Ser Ala Glu Thr Pro Thr Trp Asn Arg Lys 
            500                 505                 510         


Glu Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys Gln Glu Val 
        515                 520                 525             


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
    530                 535                 540                 


Ala Thr Glu Ile Gln Thr Ser Gly Gly Thr Ser Ile Phe Ala Gly His 
545                 550                 555                 560 


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys Gly Met Ser 
                565                 570                 575     


Tyr Ala Met Cys Leu Ser Ser Phe Val Leu Lys Lys Glu Val Ser Glu 
            580                 585                 590         


Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys Gly Glu Asp 
        595                 600                 605             


Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln Gly Lys Ala 
    610                 615                 620                 


Leu Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Lys Lys Glu 
625                 630                 635                 640 


Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Asn Ile 
                645                 650                 655     


Val Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp Tyr Lys Lys 
            660                 665                 670         


Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala Arg 
        675                 680                 685             


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly 
    690                 695                 700                 


Gly Val Leu Asn Ser Leu Gly Lys Met Val His Gln Ile Phe Gly Ser 
705                 710                 715                 720 


Ala Tyr Thr Ala Leu Phe Gly Gly Val Ser Trp Met Met Lys Ile Gly 
                725                 730                 735     


Ile Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr Ser 
            740                 745                 750         


Met Ser Phe Ser Cys Ile Ala Ala Gly Ile Val Thr Leu Tyr Leu Gly 
        755                 760                 765             


Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys Asn Lys 
    770                 775                 780                 


Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val His Thr 
785                 790                 795                 800 


Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys Leu Ala 
                805                 810                 815     


Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile Arg Ser 
            820                 825                 830         


Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro Glu Leu 
        835                 840                 845             


Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met Thr Gly 
    850                 855                 860                 


Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg Pro Gln 
865                 870                 875                 880 


Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Met 
                885                 890                 895     


Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly Pro Glu 
            900                 905                 910         


Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu Glu Val 
        915                 920                 925             


Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu 
    930                 935                 940                 


Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser Ala Ala 
945                 950                 955                 960 


Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu 
                965                 970                 975     


Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe Ile Glu 
            980                 985                 990         


Val Lys Asn Cys His Trp Pro Lys  Ser His Thr Leu Trp  Ser Asn Gly 
        995                 1000                 1005             


Val Leu  Glu Ser Glu Met Ile  Ile Pro Lys Asn Leu  Ala Gly Pro 
    1010                 1015                 1020             


Val Ser  Gln His Asn Tyr Arg  Pro Gly Tyr His Thr  Gln Ile Thr 
    1025                 1030                 1035             


Gly Pro  Trp His Leu Gly Lys  Leu Glu Met Asp Phe  Asp Phe Cys 
    1040                 1045                 1050             


Asp Gly  Thr Thr Val Val Val  Thr Glu Asp Cys Gly  Asn Arg Gly 
    1055                 1060                 1065             


Pro Ser  Leu Arg Thr Thr Thr  Ala Ser Gly Lys Leu  Ile Thr Glu 
    1070                 1075                 1080             


Trp Cys  Cys Arg Ser Cys Thr  Leu Pro Pro Leu Arg  Tyr Arg Gly 
    1085                 1090                 1095             


Glu Asp  Gly Cys Trp Tyr Gly  Met Glu Ile Arg Pro  Leu Lys Glu 
    1100                 1105                 1110             


Lys Glu  Glu Asn Leu Val Asn  Ser Leu Val Thr Ala  Gly His Gly 
    1115                 1120                 1125             


Gln Val  Asp Asn Phe Ser Leu  Gly Val Leu Gly Met  Ala Leu Phe 
    1130                 1135                 1140             


Leu Glu  Glu Met Leu Arg Thr  Arg Val Gly Thr Lys  His Ala Ile 
    1145                 1150                 1155             


Leu Leu  Val Ala Val Ser Phe  Val Thr Leu Ile Thr  Gly Asn Met 
    1160                 1165                 1170             


Ser Phe  Arg Asp Leu Gly Arg  Val Met Val Met Val  Gly Ala Thr 
    1175                 1180                 1185             


Met Thr  Asp Asp Ile Gly Met  Gly Val Thr Tyr Leu  Ala Leu Leu 
    1190                 1195                 1200             


Ala Ala  Phe Lys Val Arg Pro  Thr Phe Ala Ala Gly  Leu Leu Leu 
    1205                 1210                 1215             


Arg Lys  Leu Thr Ser Lys Glu  Leu Met Met Thr Thr  Ile Gly Ile 
    1220                 1225                 1230             


Val Leu  Leu Ser Gln Ser Thr  Ile Pro Glu Thr Ile  Leu Glu Leu 
    1235                 1240                 1245             


Thr Asp  Ala Leu Ala Leu Gly  Met Met Val Leu Lys  Met Val Arg 
    1250                 1255                 1260             


Asn Met  Glu Lys Tyr Gln Leu  Ala Val Thr Ile Met  Ala Ile Leu 
    1265                 1270                 1275             


Cys Val  Pro Asn Ala Val Ile  Leu Gln Asn Ala Trp  Lys Val Ser 
    1280                 1285                 1290             


Cys Thr  Ile Leu Ala Val Val  Ser Val Ser Pro Leu  Phe Leu Thr 
    1295                 1300                 1305             


Ser Ser  Gln Gln Lys Thr Asp  Trp Ile Pro Leu Ala  Leu Thr Ile 
    1310                 1315                 1320             


Lys Gly  Leu Asn Pro Thr Ala  Ile Phe Leu Thr Thr  Leu Ser Arg 
    1325                 1330                 1335             


Thr Ser  Lys Lys Arg Ser Trp  Pro Leu Asn Glu Ala  Ile Met Ala 
    1340                 1345                 1350             


Val Gly  Met Val Ser Ile Leu  Ala Ser Ser Leu Leu  Lys Asn Asp 
    1355                 1360                 1365             


Ile Pro  Met Thr Gly Pro Leu  Val Ala Gly Gly Leu  Leu Thr Val 
    1370                 1375                 1380             


Cys Tyr  Val Leu Thr Gly Arg  Ser Ala Asp Leu Glu  Leu Glu Arg 
    1385                 1390                 1395             


Ala Ala  Asp Val Lys Trp Glu  Asp Gln Ala Glu Ile  Ser Gly Ser 
    1400                 1405                 1410             


Ser Pro  Ile Leu Ser Ile Thr  Ile Ser Glu Asp Gly  Ser Met Ser 
    1415                 1420                 1425             


Ile Lys  Asn Glu Glu Glu Glu  Gln Thr Leu Thr Ile  Leu Ile Arg 
    1430                 1435                 1440             


Thr Gly  Leu Leu Val Ile Ser  Gly Leu Phe Pro Val  Ser Ile Pro 
    1445                 1450                 1455             


Ile Thr  Ala Ala Ala Trp Tyr  Leu Trp Glu Val Lys  Lys Gln Arg 
    1460                 1465                 1470             


Ala Gly  Val Leu Trp Asp Val  Pro Ser Pro Pro Pro  Met Gly Lys 
    1475                 1480                 1485             


Ala Glu  Leu Glu Asp Gly Ala  Tyr Arg Ile Lys Gln  Lys Gly Ile 
    1490                 1495                 1500             


Leu Gly  Tyr Ser Gln Ile Gly  Ala Gly Val Tyr Lys  Glu Gly Thr 
    1505                 1510                 1515             


Phe His  Thr Met Trp His Val  Thr Arg Gly Ala Val  Leu Met His 
    1520                 1525                 1530             


Lys Gly  Lys Arg Ile Glu Pro  Ser Trp Ala Asp Val  Lys Lys Asp 
    1535                 1540                 1545             


Leu Ile  Ser Tyr Gly Gly Gly  Trp Lys Leu Glu Gly  Glu Trp Lys 
    1550                 1555                 1560             


Glu Gly  Glu Glu Val Gln Val  Leu Ala Leu Glu Pro  Gly Lys Asn 
    1565                 1570                 1575             


Pro Arg  Ala Val Gln Thr Lys  Pro Gly Leu Phe Lys  Thr Asn Ala 
    1580                 1585                 1590             


Gly Thr  Ile Gly Ala Val Ser  Leu Asp Phe Ser Pro  Gly Thr Ser 
    1595                 1600                 1605             


Gly Ser  Pro Ile Ile Asp Lys  Lys Gly Lys Val Val  Gly Leu Tyr 
    1610                 1615                 1620             


Gly Asn  Gly Val Val Thr Arg  Ser Gly Ala Tyr Val  Ser Ala Ile 
    1625                 1630                 1635             


Ala Gln  Thr Glu Lys Ser Ile  Glu Asp Asn Pro Glu  Ile Glu Asp 
    1640                 1645                 1650             


Asp Ile  Phe Arg Lys Arg Arg  Leu Thr Ile Met Asp  Leu His Pro 
    1655                 1660                 1665             


Gly Ala  Gly Lys Thr Lys Arg  Tyr Leu Pro Ala Ile  Val Arg Glu 
    1670                 1675                 1680             


Ala Ile  Lys Arg Gly Leu Arg  Thr Leu Ile Leu Ala  Pro Thr Arg 
    1685                 1690                 1695             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Ile 
    1700                 1705                 1710             


Arg Tyr  Gln Thr Pro Ala Ile  Arg Ala Val His Thr  Gly Arg Glu 
    1715                 1720                 1725             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Met  Arg Leu Leu 
    1730                 1735                 1740             


Ser Pro  Val Arg Val Pro Asn  Tyr Asn Leu Ile Ile  Met Asp Glu 
    1745                 1750                 1755             


Ala His  Phe Thr Asp Pro Ala  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1760                 1765                 1770             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Gly Ile  Phe Met Thr 
    1775                 1780                 1785             


Ala Thr  Pro Pro Gly Ser Arg  Asp Pro Phe Pro Gln  Ser Asn Ala 
    1790                 1795                 1800             


Pro Ile  Ile Asp Glu Glu Arg  Glu Ile Pro Glu Arg  Ser Trp Asn 
    1805                 1810                 1815             


Ser Gly  His Glu Trp Val Thr  Asp Phe Lys Gly Lys  Thr Val Trp 
    1820                 1825                 1830             


Phe Val  Pro Ser Ile Lys Ala  Gly Asn Asp Ile Ala  Ala Cys Leu 
    1835                 1840                 1845             


Arg Lys  Asn Gly Lys Lys Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1850                 1855                 1860             


Asp Ser  Glu Tyr Val Lys Thr  Arg Thr Asn Asp Trp  Asp Phe Val 
    1865                 1870                 1875             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Glu 
    1880                 1885                 1890             


Arg Val  Ile Asp Pro Arg Arg  Cys Met Lys Pro Val  Ile Leu Thr 
    1895                 1900                 1905             


Asp Gly  Glu Glu Arg Val Ile  Leu Ala Gly Pro Met  Pro Val Thr 
    1910                 1915                 1920             


His Ser  Ser Ala Ala Gln Arg  Arg Gly Arg Ile Gly  Arg Asn Pro 
    1925                 1930                 1935             


Lys Asn  Glu Asn Asp Gln Tyr  Ile Tyr Met Gly Glu  Pro Leu Glu 
    1940                 1945                 1950             


Asn Asp  Glu Asp Cys Ala His  Trp Lys Glu Ala Lys  Met Leu Leu 
    1955                 1960                 1965             


Asp Asn  Ile Asn Thr Pro Glu  Gly Ile Ile Pro Ser  Met Phe Glu 
    1970                 1975                 1980             


Pro Glu  Arg Glu Lys Val Asp  Ala Ile Asp Gly Glu  Tyr Arg Leu 
    1985                 1990                 1995             


Arg Gly  Glu Ala Arg Lys Thr  Phe Val Asp Leu Met  Arg Arg Gly 
    2000                 2005                 2010             


Asp Leu  Pro Val Trp Leu Ala  Tyr Arg Val Ala Ala  Glu Gly Ile 
    2015                 2020                 2025             


Asn Tyr  Ala Asp Arg Arg Trp  Cys Phe Asp Gly Val  Lys Asn Asn 
    2030                 2035                 2040             


Gln Ile  Leu Glu Glu Asn Val  Glu Val Glu Ile Trp  Thr Lys Glu 
    2045                 2050                 2055             


Gly Glu  Arg Lys Lys Leu Lys  Pro Arg Trp Leu Asp  Ala Arg Ile 
    2060                 2065                 2070             


Tyr Ser  Asp Pro Leu Ala Leu  Lys Glu Phe Lys Glu  Phe Ala Ala 
    2075                 2080                 2085             


Gly Arg  Lys Ser Leu Thr Leu  Asn Leu Ile Thr Glu  Met Gly Arg 
    2090                 2095                 2100             


Leu Pro  Thr Phe Met Thr Gln  Lys Ala Arg Asp Ala  Leu Asp Asn 
    2105                 2110                 2115             


Leu Ala  Val Leu His Thr Ala  Glu Ala Gly Gly Arg  Ala Tyr Asn 
    2120                 2125                 2130             


His Ala  Leu Ser Glu Leu Pro  Glu Thr Leu Glu Thr  Leu Leu Leu 
    2135                 2140                 2145             


Leu Thr  Leu Leu Ala Thr Val  Thr Gly Gly Ile Phe  Leu Phe Leu 
    2150                 2155                 2160             


Met Ser  Ala Arg Gly Ile Gly  Lys Met Thr Leu Gly  Met Cys Cys 
    2165                 2170                 2175             


Ile Ile  Thr Ala Ser Ile Leu  Leu Trp Tyr Ala Gln  Ile Gln Pro 
    2180                 2185                 2190             


His Trp  Ile Ala Ala Ser Ile  Ile Leu Glu Phe Phe  Leu Ile Val 
    2195                 2200                 2205             


Leu Leu  Ile Pro Glu Pro Glu  Lys Gln Arg Thr Pro  Gln Asp Asn 
    2210                 2215                 2220             


Gln Leu  Thr Tyr Val Val Ile  Ala Ile Leu Thr Val  Val Ala Ala 
    2225                 2230                 2235             


Thr Met  Ala Asn Glu Met Gly  Phe Leu Glu Lys Thr  Lys Lys Asp 
    2240                 2245                 2250             


Leu Gly  Leu Gly Ser Ile Ala  Thr Gln Gln Pro Glu  Ser Asn Ile 
    2255                 2260                 2265             


Leu Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Thr  Leu Tyr Ala 
    2270                 2275                 2280             


Val Ala  Thr Thr Phe Val Thr  Pro Met Leu Arg His  Ser Ile Glu 
    2285                 2290                 2295             


Asn Ser  Ser Val Asn Val Ser  Leu Thr Ala Ile Ala  Asn Gln Ala 
    2300                 2305                 2310             


Thr Val  Leu Met Gly Leu Gly  Lys Gly Trp Pro Leu  Ser Lys Met 
    2315                 2320                 2325             


Asp Ile  Gly Val Pro Leu Leu  Ala Ile Gly Cys Tyr  Ser Gln Val 
    2330                 2335                 2340             


Asn Pro  Ile Thr Leu Thr Ala  Ala Leu Phe Leu Leu  Val Ala His 
    2345                 2350                 2355             


Tyr Ala  Ile Ile Gly Pro Gly  Leu Gln Ala Lys Ala  Thr Arg Glu 
    2360                 2365                 2370             


Ala Gln  Lys Arg Ala Ala Ala  Gly Ile Met Lys Asn  Pro Thr Val 
    2375                 2380                 2385             


Asp Gly  Ile Thr Val Ile Asp  Leu Asp Pro Ile Pro  Tyr Asp Pro 
    2390                 2395                 2400             


Lys Phe  Glu Lys Gln Leu Gly  Gln Val Met Leu Leu  Val Leu Cys 
    2405                 2410                 2415             


Val Thr  Gln Val Leu Met Met  Arg Thr Thr Trp Ala  Leu Cys Glu 
    2420                 2425                 2430             


Ala Leu  Thr Leu Ala Thr Gly  Pro Ile Ser Thr Leu  Trp Glu Gly 
    2435                 2440                 2445             


Asn Pro  Gly Arg Phe Trp Asn  Thr Thr Ile Ala Val  Ser Met Ala 
    2450                 2455                 2460             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Gly  Leu Leu Phe 
    2465                 2470                 2475             


Ser Ile  Met Lys Asn Thr Thr  Asn Thr Arg Arg Gly  Thr Gly Asn 
    2480                 2485                 2490             


Ile Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ser Arg  Leu Asn Ala 
    2495                 2500                 2505             


Leu Gly  Lys Ser Glu Phe Gln  Ile Tyr Lys Lys Ser  Gly Ile Gln 
    2510                 2515                 2520             


Glu Val  Asp Arg Thr Leu Ala  Lys Glu Gly Ile Lys  Arg Gly Glu 
    2525                 2530                 2535             


Thr Asp  His His Ala Val Ser  Arg Gly Ser Ala Lys  Leu Arg Trp 
    2540                 2545                 2550             


Phe Val  Glu Arg Asn Met Val  Thr Pro Glu Gly Lys  Val Val Asp 
    2555                 2560                 2565             


Leu Gly  Cys Gly Arg Gly Gly  Trp Ser Tyr Tyr Cys  Gly Gly Leu 
    2570                 2575                 2580             


Lys Asn  Val Arg Glu Val Lys  Gly Leu Thr Lys Gly  Gly Pro Gly 
    2585                 2590                 2595             


His Glu  Glu Pro Ile Pro Met  Ser Thr Tyr Gly Trp  Asn Leu Val 
    2600                 2605                 2610             


Arg Leu  Gln Ser Gly Val Asp  Val Phe Phe Ile Pro  Pro Glu Lys 
    2615                 2620                 2625             


Cys Asp  Thr Leu Leu Cys Asp  Ile Gly Glu Ser Ser  Pro Asn Pro 
    2630                 2635                 2640             


Thr Val  Glu Ala Gly Arg Thr  Leu Arg Val Leu Asn  Leu Val Glu 
    2645                 2650                 2655             


Asn Trp  Leu Asn Asn Asn Thr  Gln Phe Cys Ile Lys  Val Leu Asn 
    2660                 2665                 2670             


Pro Tyr  Met Pro Ser Val Ile  Glu Lys Met Glu Ala  Leu Gln Arg 
    2675                 2680                 2685             


Lys Tyr  Gly Gly Ala Leu Val  Arg Asn Pro Leu Ser  Arg Asn Ser 
    2690                 2695                 2700             


Thr His  Glu Met Tyr Trp Val  Ser Asn Ala Ser Gly  Asn Ile Val 
    2705                 2710                 2715             


Ser Ser  Val Asn Met Ile Ser  Arg Met Leu Ile Asn  Arg Phe Thr 
    2720                 2725                 2730             


Met Arg  Tyr Lys Lys Ala Thr  Tyr Glu Pro Asp Val  Asp Leu Gly 
    2735                 2740                 2745             


Ser Gly  Thr Arg Asn Ile Gly  Ile Glu Ser Glu Ile  Pro Asn Leu 
    2750                 2755                 2760             


Asp Ile  Ile Gly Lys Arg Ile  Glu Lys Ile Lys Gln  Glu His Glu 
    2765                 2770                 2775             


Thr Ser  Trp His Tyr Asp Gln  Asp His Pro Tyr Lys  Thr Trp Ala 
    2780                 2785                 2790             


Tyr His  Gly Ser Tyr Glu Thr  Lys Gln Thr Gly Ser  Ala Ser Ser 
    2795                 2800                 2805             


Met Val  Asn Gly Val Val Arg  Leu Leu Thr Lys Pro  Trp Asp Val 
    2810                 2815                 2820             


Val Pro  Met Val Thr Gln Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2825                 2830                 2835             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Arg Thr Gln 
    2840                 2845                 2850             


Glu Pro  Lys Glu Gly Thr Lys  Lys Leu Met Lys Ile  Thr Ala Glu 
    2855                 2860                 2865             


Trp Leu  Trp Lys Glu Leu Gly  Lys Lys Lys Thr Pro  Arg Met Cys 
    2870                 2875                 2880             


Thr Arg  Glu Glu Phe Thr Arg  Lys Val Arg Ser Asn  Ala Ala Leu 
    2885                 2890                 2895             


Gly Ala  Ile Phe Thr Asp Glu  Asn Lys Trp Lys Ser  Ala Arg Glu 
    2900                 2905                 2910             


Ala Val  Glu Asp Ser Arg Phe  Trp Glu Leu Val Asp  Lys Glu Arg 
    2915                 2920                 2925             


Asn Leu  His Leu Glu Gly Lys  Cys Glu Thr Cys Val  Tyr Asn Met 
    2930                 2935                 2940             


Met Gly  Lys Arg Glu Lys Lys  Leu Gly Glu Phe Gly  Lys Ala Lys 
    2945                 2950                 2955             


Gly Ser  Arg Ala Ile Trp Tyr  Met Trp Leu Gly Ala  Arg Phe Leu 
    2960                 2965                 2970             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Phe Ser 
    2975                 2980                 2985             


Arg Glu  Asn Ser Leu Ser Gly  Val Glu Gly Glu Gly  Leu His Lys 
    2990                 2995                 3000             


Leu Gly  Tyr Ile Leu Arg Asp  Val Ser Lys Lys Glu  Gly Gly Ala 
    3005                 3010                 3015             


Met Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Leu 
    3020                 3025                 3030             


Glu Asp  Leu Lys Asn Glu Glu  Met Val Thr Asn His  Met Glu Gly 
    3035                 3040                 3045             


Glu His  Lys Lys Leu Ala Glu  Ala Ile Phe Lys Leu  Thr Tyr Gln 
    3050                 3055                 3060             


Asn Lys  Val Val Arg Val Gln  Arg Pro Thr Pro Arg  Gly Thr Val 
    3065                 3070                 3075             


Met Asp  Ile Ile Ser Arg Arg  Asp Gln Arg Gly Ser  Gly Gln Val 
    3080                 3085                 3090             


Gly Thr  Tyr Gly Leu Asn Thr  Phe Thr Asn Met Glu  Ala Gln Leu 
    3095                 3100                 3105             


Ile Arg  Gln Met Glu Gly Glu  Gly Val Phe Lys Ser  Ile Gln His 
    3110                 3115                 3120             


Leu Thr  Ile Thr Glu Glu Ile  Ala Val Gln Asn Trp  Leu Ala Arg 
    3125                 3130                 3135             


Val Gly  Arg Glu Arg Leu Ser  Arg Met Ala Ile Ser  Gly Asp Asp 
    3140                 3145                 3150             


Cys Val  Val Lys Pro Leu Asp  Asp Arg Phe Ala Ser  Ala Leu Thr 
    3155                 3160                 3165             


Ala Leu  Asn Asp Met Gly Lys  Ile Arg Lys Asp Ile  Gln Gln Trp 
    3170                 3175                 3180             


Glu Pro  Ser Arg Gly Trp Asn  Asp Trp Thr Gln Val  Pro Phe Cys 
    3185                 3190                 3195             


Ser His  His Phe His Glu Leu  Ile Met Lys Asp Gly  Arg Val Leu 
    3200                 3205                 3210             


Val Val  Pro Cys Arg Asn Gln  Asp Glu Leu Ile Gly  Arg Ala Arg 
    3215                 3220                 3225             


Ile Ser  Gln Gly Ala Gly Trp  Ser Leu Arg Glu Thr  Ala Cys Leu 
    3230                 3235                 3240             


Gly Lys  Ser Tyr Ala Gln Met  Trp Ser Leu Met Tyr  Phe His Arg 
    3245                 3250                 3255             


Arg Asp  Leu Arg Leu Ala Ala  Asn Ala Ile Cys Ser  Ala Val Pro 
    3260                 3265                 3270             


Ser His  Trp Val Pro Thr Ser  Arg Thr Thr Trp Ser  Ile His Ala 
    3275                 3280                 3285             


Lys His  Glu Trp Met Thr Thr  Glu Asp Met Leu Thr  Val Trp Asn 
    3290                 3295                 3300             


Arg Val  Trp Ile Gln Glu Asn  Pro Trp Met Glu Asp  Lys Thr Pro 
    3305                 3310                 3315             


Val Glu  Ser Trp Glu Glu Ile  Pro Tyr Leu Gly Lys  Arg Glu Asp 
    3320                 3325                 3330             


Gln Trp  Cys Gly Ser Leu Ile  Gly Leu Thr Ser Arg  Ala Thr Trp 
    3335                 3340                 3345             


Ala Lys  Asn Ile Gln Ala Ala  Ile Asn Gln Val Arg  Ser Leu Ile 
    3350                 3355                 3360             


Gly Asn  Glu Glu Tyr Thr Asp  Tyr Met Pro Ser Met  Lys Arg Phe 
    3365                 3370                 3375             


Arg Arg  Glu Glu Glu Glu Ala  Gly Val Leu Trp 
    3380                 3385                 


<210>  10
<211>  10723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 4, BVS

<400>  10
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaatgta       60

gttctaacag ttttttaatt agagagcaga tctctgatga ataaccaacg gaaaaaggcg      120

aaaaacacgc ctttcaatat gctgaaacgc gagagaaacc gcgtgtcgac tgtgcaacag      180

ctgacaaaga gattctcact tggaatgctg cagggacgag gacctttaaa actgttcatg      240

gccctggtgg cgttccttcg tttcctaaca atcccaccaa cagcagggat attgaagaga      300

tggggaacaa ttaaaaaatc aaaagctatt aatgttttga gagggttcag gaaagagatt      360

ggaaggatgc tgaacatctt gaataggaga cgcagctctg caggcatgat cattatgctg      420

attccaacag tgatggcgtt ccatttaacc acgcgtgatg gcgaacccct catgatagtg      480

gcaaaacatg aaagggggag acctctcttg tttaagacaa cagaggggat caacaaatgc      540

actctcattg ccatggactt gggtgaaatg tgtgaggaca ctgtcacgta taaatgcccc      600

ttactggtca ataccgaacc tgaagacatt gattgctggt gcaatctcac gtctacctgg      660

gtcatgtatg ggacatgcac ccagagcgga gaacggagac gagagaagcg ctcagtagct      720

ttaacaccac attcaggaat gggattggaa acaagagctg agacatggat gtcatcggaa      780

ggggcttgga agcatgctca gagagtagag agctggatac tcagaaaccc aggattcgcg      840

ctcttggcag gatttatggc ttatatgatt gggcaaacag gaatccagcg aactgtcttc      900

tttgtcctaa tgatgctggt cgccccatcc tacggaatgc gatgcgtagg agtaggaaac      960

agagactttg tggaaggagt ctcaggtgga gcatgggtcg atctggtgct agaacatgga     1020

ggatgcgtca caaccatggc ccagggaaaa ccaaccttgg attttgaact gactaagaca     1080

acagccaagg aagtggctct gttaagaacc tattgcattg aagcctcaat atcaaacata     1140

accacggcaa caagatgtcc aacgcaagga gagccttatc taaaagagga acaagaccaa     1200

cagtacattt gccggagaga tgtggtagac agagggtggg gcaatggctg tggcttgttt     1260

ggaaaaggag gagttgtgac atgtgcgaag ttttcatgtt cggggaagat aacaggcaat     1320

ttggtccaaa ttgagaacct tgaatacaca gtggttgtaa cagtccacaa tggagacacc     1380

catgcagtag gaaatgacac gtccaatcat ggagttacag ccacgataac tcccaggtca     1440

ccatcggtgg aagtcaaatt gccggactat ggagaactaa cactcgattg tgaacccagg     1500

tctggaattg actttaatga gatgattctg atgaaaatga aaaagaaaac atggcttgtg     1560

cataagcaat ggtttttgga tctacctcta ccatggacag caggagcaga cacatcagag     1620

gttcactgga attacaaaga gagaatggtg acatttaagg ttcctcatgc caagagacag     1680

gatgtgacag tgctgggatc tcaggaagga gccatgcatt ctgccctcgc tggagccaca     1740

gaagtggact ccggtgatgg aaatcacatg tttgcaggac atctcaagtg caaagtccgt     1800

atggagaaat tgagaatcaa gggaatgtca tacacgatgt gttcaggaaa gttctcaatt     1860

gacaaagaga tggcagaaac acagcatggg acaacagtgg tgaaagtcaa gtatgaaggt     1920

gctggagctc cgtgtaaagt ccccatagag ataagagatg tgaacaagga aaaagtggtt     1980

gggcgtatca tctcatccac ccctttggct gagaatacca acagtgtaac caacatagag     2040

ttagaacccc cctttgggga cagctacata gtgataggtg ttggaaacag tgcattaaca     2100

ctccattggt tcaggaaagg gagttccatt ggcaagatgt ttgagtccac atacagaggt     2160

gcaaaacgaa tggccattct aggtgaaaca gcttgggatt ttggttccgt tggtggactg     2220

ttcacatcat tgggaaaggc tgtgcaccag gtttttggaa gtgtgtatac aaccctgttt     2280

ggaggagtct catggatgat tagaatccta attgggttcc tagtgttgtg gattggcacg     2340

aactcaagga acacttcaat ggctatgacg tgcatagctg ccggcattgt gacactgtat     2400

ttgggagtca tggtgcaggc cgatagtggt tgcgttgtga gctggaaaaa caaagaactg     2460

aaatgtggca gtgggatttt catcacagac aacgtgcaca catggacaga acaatacaag     2520

ttccaaccag aatccccttc aaaactagct tcagctatcc agaaagccca tgaagaggac     2580

atttgtggaa tccgctcagt aacaagactg gagaatctga tgtggaaaca aataacacca     2640

gaattgaatc acattctatc agaaaatgag gtgaagttaa ctattatgac aggagacatc     2700

aaaggaatca tgcaggcagg aaaacgatct ctgcggcctc agcccactga gctgaagtat     2760

tcatggaaaa catggggcaa agcaaaaatg ctctctacag agtctcataa ccagaccttt     2820

ctcattgatg gccccgaaac agcagaatgc cccaacacaa atagagcttg gaattcgttg     2880

gaagttgaag actatggctt tggagtattc accaccaata tatggctaaa attgaaagaa     2940

aaacaggatg tattctgcga ctcaaaactc atgtcagcgg ccataaaaga caacagagcc     3000

gtccatgccg atatgggtta ttggatagaa agtgcactca atgacacatg gaagatagag     3060

aaagcctctt tcattgaagt taaaaactgc cactggccaa aatcacacac cctctggagc     3120

aatggagtgc tagaaagtga gatgataatt ccaaagaatc tcgctggacc agtgtctcaa     3180

cacaactata gaccaggcta ccatacacaa ataacaggac catggcatct aggtaagctt     3240

gagatggact ttgatttctg tgatggaaca acagtggtag tgactgagga ctgcggaaat     3300

agaggaccct ctttgagaac aaccactgcc tctggaaaac tcataacaga atggtgctgc     3360

cgatcttgca cattaccacc gctaagatac agaggtgagg atgggtgctg gtacgggatg     3420

gaaatcagac cattgaagga gaaagaagag aatttggtca actccttggt cacagctgga     3480

catgggcagg tcgacaactt ttcactagga gtcttgggaa tggcattgtt cctggaggaa     3540

atgcttagga cccgagtagg aacgaaacat gcaatactac tagttgcagt ttcttttgtg     3600

acattgatca cagggaacat gtcctttaga gacctgggaa gagtgatggt tatggtaggc     3660

gccactatga cgggtgacat aggtatgggc gtgacttatc ttgccctact agcagccttc     3720

aaagtcagac caacttttgc agctggacta ctcttgagaa agctgacctc cagggaattg     3780

atgatgacta ctataggaat tgtactcctc tcccagagca ccataccaga gaccattctt     3840

gagttgactg atgcgttagc cttaggcatg atggtcctca aaatggtgag aaatatggaa     3900

aagtatcaat tggcagtgac tatcatggct atcttgtgcg tcccaaacgc agtgatatta     3960

caaaacgcat ggaaagtgag ttgcacaata ttggcagtgg tgtccgtttc cccactgttc     4020

ttaacatcct cacagcaaaa aacagattgg ataccattag cattgacgat caaaggtctc     4080

aatccaacag ctatttttct aacaaccctc tcaagaacca gcaagaaaag gagctggcca     4140

ttaaatgagg ctatcatggc agtcgggatg gtgagcattt tagccagttc tctcctaaaa     4200

aatgatattc ccatgacagg accattagtg gctggagggc tcctcactgt gtgctacgtg     4260

ctcactggac gatcggccga tttggaactg gagagagcag ccgatgtcaa atgggaagac     4320

caggcagaga tatcaggaag cagtccaatc ctgtcaataa caatatcaga agatggtagc     4380

atgtcgataa aaaatgaaga ggaagaacaa acactgacca tactcattag aacaggattg     4440

ctggtgatct caggactttt tcctgtatca ataccaatca cggcagcagc atggtacctg     4500

tgggaagtga agaaacaacg ggccggagta ttgtgggatg ttccttcacc cccacccatg     4560

ggaaaggctg aactggaaga tggagcctat agaattaagc aaaaagggat tcttggatat     4620

tcccagatcg gagccggagt ttacaaagaa ggaacattcc atacaatgtg gcatgtcaca     4680

cgtggcgctg ttctaatgca taaaggaaag aggattgaac catcatgggc ggacgtcaag     4740

aaagacctaa tatcatatgg aggaggctgg aagttagaag gagaatggaa ggaaggagaa     4800

gaagtccagg tattggcact ggagcctgga aaaaatccaa gagccgtcca aacgaaacct     4860

ggtcttttca aaaccaacgc cggaacaata ggtgctgtat ctctggactt ttctcctgga     4920

acgtcaggat ctccaattat cgacaaaaaa ggaaaagttg tgggtcttta tggtaatggt     4980

gttgttacaa ggagtggagc atatgtgagt gctatagccc agactgaaaa aagcattgaa     5040

gacaacccag agatcgaaga tgacattttc cgaaagagaa gactgaccat catggacctc     5100

cacccaggag cgggaaagac gaagagatac cttccggcca tagtcagaga agctataaaa     5160

cggggtttga gaacattaat cttggccccc actagagttg tggcagctga aatggaggaa     5220

gcccttagag gacttccaat aagataccag accccagcca tcagagctgt gcacaccggg     5280

cgggagattg tggacctaat gtgtcatgcc acatttacca tgaggctgct atcaccagtt     5340

agagtgccaa actacaacct gattatcatg gacgaagccc atttcacaga tccagcaagt     5400

atagcagcta gaggatacat ctcaactcga gtggagatgg gtgaggcagc tgggattttt     5460

atgacagcca ctcccccggg aagcagagac ccatttcctc agagcaatgc accaatcata     5520

gatgaagaaa gagaaatccc tgaacgctcg tggaattccg gacatgaatg ggtcacggat     5580

tttaaaggga agactgtttg gttcgttcca agtataaaag caggaaatga tatagcagct     5640

tgcctgagga aaaatggaaa gaaagtgata caactcagta ggaagacctt tgattctgag     5700

tatgtcaaga ctagaaccaa tgattgggac ttcgtggtta caactgacat ttcagaaatg     5760

ggtgccaatt tcaaggctga gagggttata gaccccagac gctgcatgaa accagtcata     5820

ctaacagatg gtgaagagcg ggtgattctg gcaggaccta tgccagtgac ccactctagt     5880

gcagcacaaa gaagagggag aataggaaga aatccaaaaa atgagaatga ccagtacata     5940

tacatggggg aacctctgga aaatgatgaa gactgtgcac actggaaaga agctaaaatg     6000

ctcctagata acatcaacac gccagaagga atcattccta gcatgttcga accagagcgt     6060

gaaaaggtgg atgccattga tggcgaatac cgcttgagag gagaagcaag gaaaaccttt     6120

gtagacttaa tgagaagagg agacctacca gtctggttgg cctacagagt ggcagctgaa     6180

ggcatcaact acgcagacag aaggtggtgt tttgatggag tcaagaacaa ccaaatccta     6240

gaagaaaacg tggaagttga aatctggaca aaagaagggg aaaggaagaa attgaaaccc     6300

agatggttgg atgctaggat ctattctgac ccactggcgc taaaagaatt taaggaattt     6360

gcagccggaa gaaagtctct gaccctgaac ctaatcacag aaatgggtag gctcccaacc     6420

ttcatgactc agaaggtaag agacgcactg gacaacttag cagtgctgca cacggctgag     6480

gcaggtggaa gggcgtacaa ccatgctctc agtgaactgc cggagaccct ggagacattg     6540

cttttactga cacttctggc tacagtcacg ggagggatct ttttattctt gatgagcgca     6600

aggggcatag ggaagatgac cctgggaatg tgctgcataa tcacggctag catcctccta     6660

tggtacgcac aaatacagcc acactggata gcagcttcaa taatactgga gttttttctc     6720

atagttttgc ttattccaga acctgaaaaa cagagaacac cccaagacaa ccaactgacc     6780

tacgttgtca tagccatcct cacagtggtg gccgcaacca tggcaaacga gatgggtttc     6840

ctagaaaaaa cgaagaaaga tctcggattg ggaagcattg caacccagca acccgagagc     6900

aacatcctgg acatagatct acgtcctgca tcagcatgga cgctgtatgc cgtggccaca     6960

acatttgtta caccaatgtt gagacatagc attgaaaatt cctcagtgaa tgtgtcccta     7020

acagccatag ccaaccaagc cacagtgtta atgggtctcg ggaaaggatg gccattgtca     7080

aagatggaca tcggagttcc ccttctcgcc attggatgct actcacaagt caaccccata     7140

actctcacag cagctctttt cttattggta gcacattatg ccatcatagg gccaggactc     7200

caagcaaaag caaccagaga agctcagaaa agagcagcgg cgggcatcat gaaaaaccca     7260

actgtcgatg gaataacagt gattgaccta gatccaatac cttatgatcc aaagtttgaa     7320

aagcagttgg gacaagtaat gctcctagtc ctctgcgtga ctcaagtatt gatgatgagg     7380

actacatggg ctctgtgtga ggctttaacc ttagctaccg ggcccatctc cacattgtgg     7440

gaaggaaatc cagggaggtt ttggaacact accattgcgg tgtcaatggc taacattttt     7500

agagggagtt acttggccgg agctggactt ctctttttta ttatgaagaa cacaaccaac     7560

acaagaaggg gaactggcaa cataggagag acgcttggag agaaatggaa aagccgattg     7620

aacgcattgg gaaaaagtga attccagatc tacaagaaaa gtggaatcca ggaagtggat     7680

agaaccttag caaaagaagg cattaaaaga ggagaaacgg accatcacgc tgtgtcgcga     7740

ggctcagcaa aactgagatg gttcgttgag agaaacatgg tcacaccaga agggaaagta     7800

gtggacctcg gttgtggcag aggaggctgg tcatactatt gtggaggact aaagaatgta     7860

agagaagtca aaggcctaac aaaaggagga ccaggacacg aagaacccat ccccatgtca     7920

acatatgggt ggaatctagt gcgtcttcaa agtggagttg acgttttctt catcccgcca     7980

gaaaagtgtg acacattatt gtgtgacata ggggagtcat caccaaatcc cacagtggaa     8040

gcaggacgaa cactcagagt ccttaactta gtagaaaatt ggttgaacaa caacactcaa     8100

ttttgcataa aggttctcaa cccatatatg ccctcagtca tagaaaaaat ggaagcacta     8160

caaaggaaat atggaggagc cttagtgagg aatccactct cacgaaactc cacacatgag     8220

atgtactggg tatccaatgc ttccgggaac atagtgtcat cagtgaacat gatttcaagg     8280

atgttgatca acagatttac aatgagatac aagaaagcca cttacgagcc ggatgttgac     8340

ctcggaagcg gaacccgtaa catcgggatt gaaagtgaga taccaaacct agatataatt     8400

gggaaaagaa tagaaaaaat aaagcaagag catgaaacat catggcacta tgaccaagac     8460

cacccataca aaacgtgggc ataccatggt agctatgaaa caaaacagac tggatcagca     8520

tcatccatgg tcaacggagt ggtcaggctg ctgacaaaac cttgggacgt cgtccccatg     8580

gtgacacaga tggcaatgac agacacgact ccatttggac aacagcgcgt ttttaaagag     8640

aaagtggaca cgagaaccca agaaccgaaa gaaggcacga agaaactaat gaaaataaca     8700

gcagagtggc tttggaaaga attagggaag aaaaagacac ccaggatgtg caccagagaa     8760

gaattcacaa gaaaggtgag aagcaatgca gccttggggg ccatattcac tgatgagaac     8820

aagtggaagt cggcacgtga ggctgttgaa gatagtaggt tttgggagct ggttgacaag     8880

gaaaggaatc tccatcttga aggaaagtgt gaaacatgtg tgtacaacat gatgggaaaa     8940

agagagaaga agctagggga attcggcaag gcaaaaggca gcagagccat atggtacatg     9000

tggcttggag cacgcttctt agagtttgaa gccctaggat tcttaaatga agatcactgg     9060

ttctccagag agaactccct gagtggagtg gaaggagaag ggctgcacaa gctaggttac     9120

attctaagag acgtgagcaa gaaagaggga ggagcaatgt atgccgatga caccgcagga     9180

tgggatacaa gaatcacact agaagaccta aaaaatgaag aaatggtaac aaaccacatg     9240

gaaggagaac acaagaaact agccgaggcc attttcaaac taacgtacca aaacaaggtg     9300

gtgcgtgtgc aaagaccaac accaagaggc acagtaatgg acatcatatc gagaagagac     9360

caaagaggta gtggacaagt tggcacctat ggactcaata ctttcaccaa tatggaagcc     9420

caactaatca gacagatgga gggagaagga gtctttaaaa gcattcagca cctaacaatc     9480

acagaagaaa tcgctgtgca aaactggtta gcaagagtgg ggcgcgaaag gttatcaaga     9540

atggccatca gtggagatga ttgtgttgtg aaacctttag atgacaggtt cgcaagcgct     9600

ttaacagctc taaatgacat gggaaagatt aggaaagaca tacaacaatg ggaaccttca     9660

agaggatgga atgattggac acaagtgccc ttctgttcac accatttcca tgagttaatc     9720

atgaaagacg gtcgcgtact cgttgttccc tgtagaaacc aagatgaact gattggcaga     9780

gcccgaatct cccaaggagc agggtggtct ttgcgggaga cggcctgttt ggggaagtct     9840

tacgcccaaa tgtggagctt gatgtacttc cacagacgcg acctcaggct ggcggcaaat     9900

gctatttgct cggcagtacc atcacattgg gttccaacaa gtcgaacaac ctggtccata     9960

catgctaaac atgaatggat gacaacggaa gacatgctga cagtctggaa cagggtgtgg    10020

attcaagaaa acccatggat ggaagacaaa actccagtgg aatcatggga ggaaatccca    10080

tacttgggga aaagagaaga ccaatggtgc ggctcattga ttgggttaac aagcagggcc    10140

acctgggcaa agaacatcca agcagcaata aatcaagtta gatcccttat aggcaatgaa    10200

gaatacacag attacatgcc atccatgaaa agattcagaa gagaagagga agaagcagga    10260

gttctgtggt agaaagcaaa actaacatga aacaaggcta gaagtcaggt cggattaagc    10320

catagtacgg aaaaaactat gctacctgtg agccccgtcc aaggacgtta aaagaagtca    10380

ggccatcata aatgccatag cttgagtaaa ctatgcagcc tgtagctcca cctgagaagg    10440

tgtaaaaaat ccgggaggcc acaaaccatg gaagctgtac gcatggcgta gtggactagc    10500

ggttagagga gacccctccc ttacaaatcg cagcaacaat gggggcccaa ggcgagatga    10560

agctgtagtc tcgctggaag gactagaggt tagaggagac ccccccgaaa caaaaaacag    10620

catattgacg ctgggaaaga ccagagatcc tgctgtctcc tcagcatcat tccaggcaca    10680

gaacgccaga aaatggaatg gtgctgttga atcaacaggt tct                      10723


<210>  11
<211>  3391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 4, BVS

<400>  11

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Ser Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Asp Gly Glu Pro Leu Met Ile Val 
        115                 120                 125             


Ala Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly 
    130                 135                 140                 


Ile Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Glu 
145                 150                 155                 160 


Asp Thr Val Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Met Tyr Gly 
            180                 185                 190         


Thr Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp 
225                 230                 235                 240 


Ile Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr 
                245                 250                 255     


Met Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu Met 
            260                 265                 270         


Met Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val Gly Val Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu Val 
    290                 295                 300                 


Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu Leu 
                325                 330                 335     


Arg Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln 
        355                 360                 365             


Gln Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe Ser 
385                 390                 395                 400 


Cys Ser Gly Lys Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu Glu 
                405                 410                 415     


Tyr Thr Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val Gly 
            420                 425                 430         


Asn Asp Thr Ser Asn His Gly Val Thr Ala Thr Ile Thr Pro Arg Ser 
        435                 440                 445             


Pro Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp 
    450                 455                 460                 


Cys Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys 
465                 470                 475                 480 


Met Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp Asn 
            500                 505                 510         


Tyr Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys Arg Gln 
        515                 520                 525             


Asp Val Thr Val Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala Leu 
    530                 535                 540                 


Ala Gly Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe Ala 
545                 550                 555                 560 


Gly His Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly 
                565                 570                 575     


Met Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly 
        595                 600                 605             


Ala Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys 
    610                 615                 620                 


Glu Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala Glu Asn 
625                 630                 635                 640 


Thr Asn Ser Val Thr Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser 
                645                 650                 655     


Tyr Ile Val Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp Phe 
            660                 665                 670         


Arg Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly 
        675                 680                 685             


Ala Lys Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln Val Phe 
705                 710                 715                 720 


Gly Ser Val Tyr Thr Thr Leu Phe Gly Gly Val Ser Trp Met Ile Arg 
                725                 730                 735     


Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg Asn 
            740                 745                 750         


Thr Ser Met Ala Met Thr Cys Ile Ala Ala Gly Ile Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 
    770                 775                 780                 


Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 
                805                 810                 815     


Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile 
            820                 825                 830         


Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 
        835                 840                 845             


Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 
    850                 855                 860                 


Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 
865                 870                 875                 880 


Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 
                885                 890                 895     


Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 
            900                 905                 910         


Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Asn Cys His Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Asn Leu Ala 
    1010                 1015                 1020             


Gly Pro  Val Ser Gln His Asn  Tyr Arg Pro Gly Tyr  His Thr Gln 
    1025                 1030                 1035             


Ile Thr  Gly Pro Trp His Leu  Gly Lys Leu Glu Met  Asp Phe Asp 
    1040                 1045                 1050             


Phe Cys  Asp Gly Thr Thr Val  Val Val Thr Glu Asp  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Ala Ser Gly  Lys Leu Ile 
    1070                 1075                 1080             


Thr Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr 
    1085                 1090                 1095             


Arg Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Leu 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Asn Ser Leu Val  Thr Ala Gly 
    1115                 1120                 1125             


His Gly  Gln Val Asp Asn Phe  Ser Leu Gly Val Leu  Gly Met Ala 
    1130                 1135                 1140             


Leu Phe  Leu Glu Glu Met Leu  Arg Thr Arg Val Gly  Thr Lys His 
    1145                 1150                 1155             


Ala Ile  Leu Leu Val Ala Val  Ser Phe Val Thr Leu  Ile Thr Gly 
    1160                 1165                 1170             


Asn Met  Ser Phe Arg Asp Leu  Gly Arg Val Met Val  Met Val Gly 
    1175                 1180                 1185             


Ala Thr  Met Thr Gly Asp Ile  Gly Met Gly Val Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Leu  Ala Ala Phe Lys Val  Arg Pro Thr Phe Ala  Ala Gly Leu 
    1205                 1210                 1215             


Leu Leu  Arg Lys Leu Thr Ser  Arg Glu Leu Met Met  Thr Thr Ile 
    1220                 1225                 1230             


Gly Ile  Val Leu Leu Ser Gln  Ser Thr Ile Pro Glu  Thr Ile Leu 
    1235                 1240                 1245             


Glu Leu  Thr Asp Ala Leu Ala  Leu Gly Met Met Val  Leu Lys Met 
    1250                 1255                 1260             


Val Arg  Asn Met Glu Lys Tyr  Gln Leu Ala Val Thr  Ile Met Ala 
    1265                 1270                 1275             


Ile Leu  Cys Val Pro Asn Ala  Val Ile Leu Gln Asn  Ala Trp Lys 
    1280                 1285                 1290             


Val Ser  Cys Thr Ile Leu Ala  Val Val Ser Val Ser  Pro Leu Phe 
    1295                 1300                 1305             


Leu Thr  Ser Ser Gln Gln Lys  Thr Asp Trp Ile Pro  Leu Ala Leu 
    1310                 1315                 1320             


Thr Ile  Lys Gly Leu Asn Pro  Thr Ala Ile Phe Leu  Thr Thr Leu 
    1325                 1330                 1335             


Ser Arg  Thr Ser Lys Lys Arg  Ser Trp Pro Leu Asn  Glu Ala Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Met Val Ser  Ile Leu Ala Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Ile Pro Met Thr Gly  Pro Leu Val Ala Gly  Gly Leu Leu 
    1370                 1375                 1380             


Thr Val  Cys Tyr Val Leu Thr  Gly Arg Ser Ala Asp  Leu Glu Leu 
    1385                 1390                 1395             


Glu Arg  Ala Ala Asp Val Lys  Trp Glu Asp Gln Ala  Glu Ile Ser 
    1400                 1405                 1410             


Gly Ser  Ser Pro Ile Leu Ser  Ile Thr Ile Ser Glu  Asp Gly Ser 
    1415                 1420                 1425             


Met Ser  Ile Lys Asn Glu Glu  Glu Glu Gln Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Ile Arg  Thr Gly Leu Leu Val  Ile Ser Gly Leu Phe  Pro Val Ser 
    1445                 1450                 1455             


Ile Pro  Ile Thr Ala Ala Ala  Trp Tyr Leu Trp Glu  Val Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ala Gly Val Leu Trp  Asp Val Pro Ser Pro  Pro Pro Met 
    1475                 1480                 1485             


Gly Lys  Ala Glu Leu Glu Asp  Gly Ala Tyr Arg Ile  Lys Gln Lys 
    1490                 1495                 1500             


Gly Ile  Leu Gly Tyr Ser Gln  Ile Gly Ala Gly Val  Tyr Lys Glu 
    1505                 1510                 1515             


Gly Thr  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met His  Lys Gly Lys Arg Ile  Glu Pro Ser Trp Ala  Asp Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Lys Leu  Glu Gly Glu 
    1550                 1555                 1560             


Trp Lys  Glu Gly Glu Glu Val  Gln Val Leu Ala Leu  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Arg Ala Val Gln  Thr Lys Pro Gly Leu  Phe Lys Thr 
    1580                 1585                 1590             


Asn Ala  Gly Thr Ile Gly Ala  Val Ser Leu Asp Phe  Ser Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Ile  Asp Lys Lys Gly Lys  Val Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Arg Ser Gly Ala  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Thr Glu Lys  Ser Ile Glu Asp Asn  Pro Glu Ile 
    1640                 1645                 1650             


Glu Asp  Asp Ile Phe Arg Lys  Arg Arg Leu Thr Ile  Met Asp Leu 
    1655                 1660                 1665             


His Pro  Gly Ala Gly Lys Thr  Lys Arg Tyr Leu Pro  Ala Ile Val 
    1670                 1675                 1680             


Arg Glu  Ala Ile Lys Arg Gly  Leu Arg Thr Leu Ile  Leu Ala Pro 
    1685                 1690                 1695             


Thr Arg  Val Val Ala Ala Glu  Met Glu Glu Ala Leu  Arg Gly Leu 
    1700                 1705                 1710             


Pro Ile  Arg Tyr Gln Thr Pro  Ala Ile Arg Ala Val  His Thr Gly 
    1715                 1720                 1725             


Arg Glu  Ile Val Asp Leu Met  Cys His Ala Thr Phe  Thr Met Arg 
    1730                 1735                 1740             


Leu Leu  Ser Pro Val Arg Val  Pro Asn Tyr Asn Leu  Ile Ile Met 
    1745                 1750                 1755             


Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly 
    1760                 1765                 1770             


Tyr Ile  Ser Thr Arg Val Glu  Met Gly Glu Ala Ala  Gly Ile Phe 
    1775                 1780                 1785             


Met Thr  Ala Thr Pro Pro Gly  Ser Arg Asp Pro Phe  Pro Gln Ser 
    1790                 1795                 1800             


Asn Ala  Pro Ile Ile Asp Glu  Glu Arg Glu Ile Pro  Glu Arg Ser 
    1805                 1810                 1815             


Trp Asn  Ser Gly His Glu Trp  Val Thr Asp Phe Lys  Gly Lys Thr 
    1820                 1825                 1830             


Val Trp  Phe Val Pro Ser Ile  Lys Ala Gly Asn Asp  Ile Ala Ala 
    1835                 1840                 1845             


Cys Leu  Arg Lys Asn Gly Lys  Lys Val Ile Gln Leu  Ser Arg Lys 
    1850                 1855                 1860             


Thr Phe  Asp Ser Glu Tyr Val  Lys Thr Arg Thr Asn  Asp Trp Asp 
    1865                 1870                 1875             


Phe Val  Val Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys 
    1880                 1885                 1890             


Ala Glu  Arg Val Ile Asp Pro  Arg Arg Cys Met Lys  Pro Val Ile 
    1895                 1900                 1905             


Leu Thr  Asp Gly Glu Glu Arg  Val Ile Leu Ala Gly  Pro Met Pro 
    1910                 1915                 1920             


Val Thr  His Ser Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg 
    1925                 1930                 1935             


Asn Pro  Lys Asn Glu Asn Asp  Gln Tyr Ile Tyr Met  Gly Glu Pro 
    1940                 1945                 1950             


Leu Glu  Asn Asp Glu Asp Cys  Ala His Trp Lys Glu  Ala Lys Met 
    1955                 1960                 1965             


Leu Leu  Asp Asn Ile Asn Thr  Pro Glu Gly Ile Ile  Pro Ser Met 
    1970                 1975                 1980             


Phe Glu  Pro Glu Arg Glu Lys  Val Asp Ala Ile Asp  Gly Glu Tyr 
    1985                 1990                 1995             


Arg Leu  Arg Gly Glu Ala Arg  Lys Thr Phe Val Asp  Leu Met Arg 
    2000                 2005                 2010             


Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr Arg Val  Ala Ala Glu 
    2015                 2020                 2025             


Gly Ile  Asn Tyr Ala Asp Arg  Arg Trp Cys Phe Asp  Gly Val Lys 
    2030                 2035                 2040             


Asn Asn  Gln Ile Leu Glu Glu  Asn Val Glu Val Glu  Ile Trp Thr 
    2045                 2050                 2055             


Lys Glu  Gly Glu Arg Lys Lys  Leu Lys Pro Arg Trp  Leu Asp Ala 
    2060                 2065                 2070             


Arg Ile  Tyr Ser Asp Pro Leu  Ala Leu Lys Glu Phe  Lys Glu Phe 
    2075                 2080                 2085             


Ala Ala  Gly Arg Lys Ser Leu  Thr Leu Asn Leu Ile  Thr Glu Met 
    2090                 2095                 2100             


Gly Arg  Leu Pro Thr Phe Met  Thr Gln Lys Val Arg  Asp Ala Leu 
    2105                 2110                 2115             


Asp Asn  Leu Ala Val Leu His  Thr Ala Glu Ala Gly  Gly Arg Ala 
    2120                 2125                 2130             


Tyr Asn  His Ala Leu Ser Glu  Leu Pro Glu Thr Leu  Glu Thr Leu 
    2135                 2140                 2145             


Leu Leu  Leu Thr Leu Leu Ala  Thr Val Thr Gly Gly  Ile Phe Leu 
    2150                 2155                 2160             


Phe Leu  Met Ser Ala Arg Gly  Ile Gly Lys Met Thr  Leu Gly Met 
    2165                 2170                 2175             


Cys Cys  Ile Ile Thr Ala Ser  Ile Leu Leu Trp Tyr  Ala Gln Ile 
    2180                 2185                 2190             


Gln Pro  His Trp Ile Ala Ala  Ser Ile Ile Leu Glu  Phe Phe Leu 
    2195                 2200                 2205             


Ile Val  Leu Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Thr Pro Gln 
    2210                 2215                 2220             


Asp Asn  Gln Leu Thr Tyr Val  Val Ile Ala Ile Leu  Thr Val Val 
    2225                 2230                 2235             


Ala Ala  Thr Met Ala Asn Glu  Met Gly Phe Leu Glu  Lys Thr Lys 
    2240                 2245                 2250             


Lys Asp  Leu Gly Leu Gly Ser  Ile Ala Thr Gln Gln  Pro Glu Ser 
    2255                 2260                 2265             


Asn Ile  Leu Asp Ile Asp Leu  Arg Pro Ala Ser Ala  Trp Thr Leu 
    2270                 2275                 2280             


Tyr Ala  Val Ala Thr Thr Phe  Val Thr Pro Met Leu  Arg His Ser 
    2285                 2290                 2295             


Ile Glu  Asn Ser Ser Val Asn  Val Ser Leu Thr Ala  Ile Ala Asn 
    2300                 2305                 2310             


Gln Ala  Thr Val Leu Met Gly  Leu Gly Lys Gly Trp  Pro Leu Ser 
    2315                 2320                 2325             


Lys Met  Asp Ile Gly Val Pro  Leu Leu Ala Ile Gly  Cys Tyr Ser 
    2330                 2335                 2340             


Gln Val  Asn Pro Ile Thr Leu  Thr Ala Ala Leu Phe  Leu Leu Val 
    2345                 2350                 2355             


Ala His  Tyr Ala Ile Ile Gly  Pro Gly Leu Gln Ala  Lys Ala Thr 
    2360                 2365                 2370             


Arg Glu  Ala Gln Lys Arg Ala  Ala Ala Gly Ile Met  Lys Asn Pro 
    2375                 2380                 2385             


Thr Val  Asp Gly Ile Thr Val  Ile Asp Leu Asp Pro  Ile Pro Tyr 
    2390                 2395                 2400             


Asp Pro  Lys Phe Glu Lys Gln  Leu Gly Gln Val Met  Leu Leu Val 
    2405                 2410                 2415             


Leu Cys  Val Thr Gln Val Leu  Met Met Arg Thr Thr  Trp Ala Leu 
    2420                 2425                 2430             


Cys Glu  Ala Leu Thr Leu Ala  Thr Gly Pro Ile Ser  Thr Leu Trp 
    2435                 2440                 2445             


Glu Gly  Asn Pro Gly Arg Phe  Trp Asn Thr Thr Ile  Ala Val Ser 
    2450                 2455                 2460             


Met Ala  Asn Ile Phe Arg Gly  Ser Tyr Leu Ala Gly  Ala Gly Leu 
    2465                 2470                 2475             


Leu Phe  Phe Ile Met Lys Asn  Thr Thr Asn Thr Arg  Arg Gly Thr 
    2480                 2485                 2490             


Gly Asn  Ile Gly Glu Thr Leu  Gly Glu Lys Trp Lys  Ser Arg Leu 
    2495                 2500                 2505             


Asn Ala  Leu Gly Lys Ser Glu  Phe Gln Ile Tyr Lys  Lys Ser Gly 
    2510                 2515                 2520             


Ile Gln  Glu Val Asp Arg Thr  Leu Ala Lys Glu Gly  Ile Lys Arg 
    2525                 2530                 2535             


Gly Glu  Thr Asp His His Ala  Val Ser Arg Gly Ser  Ala Lys Leu 
    2540                 2545                 2550             


Arg Trp  Phe Val Glu Arg Asn  Met Val Thr Pro Glu  Gly Lys Val 
    2555                 2560                 2565             


Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp Ser Tyr  Tyr Cys Gly 
    2570                 2575                 2580             


Gly Leu  Lys Asn Val Arg Glu  Val Lys Gly Leu Thr  Lys Gly Gly 
    2585                 2590                 2595             


Pro Gly  His Glu Glu Pro Ile  Pro Met Ser Thr Tyr  Gly Trp Asn 
    2600                 2605                 2610             


Leu Val  Arg Leu Gln Ser Gly  Val Asp Val Phe Phe  Ile Pro Pro 
    2615                 2620                 2625             


Glu Lys  Cys Asp Thr Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Pro 
    2630                 2635                 2640             


Asn Pro  Thr Val Glu Ala Gly  Arg Thr Leu Arg Val  Leu Asn Leu 
    2645                 2650                 2655             


Val Glu  Asn Trp Leu Asn Asn  Asn Thr Gln Phe Cys  Ile Lys Val 
    2660                 2665                 2670             


Leu Asn  Pro Tyr Met Pro Ser  Val Ile Glu Lys Met  Glu Ala Leu 
    2675                 2680                 2685             


Gln Arg  Lys Tyr Gly Gly Ala  Leu Val Arg Asn Pro  Leu Ser Arg 
    2690                 2695                 2700             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Asn Ala  Ser Gly Asn 
    2705                 2710                 2715             


Ile Val  Ser Ser Val Asn Met  Ile Ser Arg Met Leu  Ile Asn Arg 
    2720                 2725                 2730             


Phe Thr  Met Arg Tyr Lys Lys  Ala Thr Tyr Glu Pro  Asp Val Asp 
    2735                 2740                 2745             


Leu Gly  Ser Gly Thr Arg Asn  Ile Gly Ile Glu Ser  Glu Ile Pro 
    2750                 2755                 2760             


Asn Leu  Asp Ile Ile Gly Lys  Arg Ile Glu Lys Ile  Lys Gln Glu 
    2765                 2770                 2775             


His Glu  Thr Ser Trp His Tyr  Asp Gln Asp His Pro  Tyr Lys Thr 
    2780                 2785                 2790             


Trp Ala  Tyr His Gly Ser Tyr  Glu Thr Lys Gln Thr  Gly Ser Ala 
    2795                 2800                 2805             


Ser Ser  Met Val Asn Gly Val  Val Arg Leu Leu Thr  Lys Pro Trp 
    2810                 2815                 2820             


Asp Val  Val Pro Met Val Thr  Gln Met Ala Met Thr  Asp Thr Thr 
    2825                 2830                 2835             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2840                 2845                 2850             


Thr Gln  Glu Pro Lys Glu Gly  Thr Lys Lys Leu Met  Lys Ile Thr 
    2855                 2860                 2865             


Ala Glu  Trp Leu Trp Lys Glu  Leu Gly Lys Lys Lys  Thr Pro Arg 
    2870                 2875                 2880             


Met Cys  Thr Arg Glu Glu Phe  Thr Arg Lys Val Arg  Ser Asn Ala 
    2885                 2890                 2895             


Ala Leu  Gly Ala Ile Phe Thr  Asp Glu Asn Lys Trp  Lys Ser Ala 
    2900                 2905                 2910             


Arg Glu  Ala Val Glu Asp Ser  Arg Phe Trp Glu Leu  Val Asp Lys 
    2915                 2920                 2925             


Glu Arg  Asn Leu His Leu Glu  Gly Lys Cys Glu Thr  Cys Val Tyr 
    2930                 2935                 2940             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Leu Gly Glu  Phe Gly Lys 
    2945                 2950                 2955             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2960                 2965                 2970             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    2975                 2980                 2985             


Phe Ser  Arg Glu Asn Ser Leu  Ser Gly Val Glu Gly  Glu Gly Leu 
    2990                 2995                 3000             


His Lys  Leu Gly Tyr Ile Leu  Arg Asp Val Ser Lys  Lys Glu Gly 
    3005                 3010                 3015             


Gly Ala  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3020                 3025                 3030             


Thr Leu  Glu Asp Leu Lys Asn  Glu Glu Met Val Thr  Asn His Met 
    3035                 3040                 3045             


Glu Gly  Glu His Lys Lys Leu  Ala Glu Ala Ile Phe  Lys Leu Thr 
    3050                 3055                 3060             


Tyr Gln  Asn Lys Val Val Arg  Val Gln Arg Pro Thr  Pro Arg Gly 
    3065                 3070                 3075             


Thr Val  Met Asp Ile Ile Ser  Arg Arg Asp Gln Arg  Gly Ser Gly 
    3080                 3085                 3090             


Gln Val  Gly Thr Tyr Gly Leu  Asn Thr Phe Thr Asn  Met Glu Ala 
    3095                 3100                 3105             


Gln Leu  Ile Arg Gln Met Glu  Gly Glu Gly Val Phe  Lys Ser Ile 
    3110                 3115                 3120             


Gln His  Leu Thr Ile Thr Glu  Glu Ile Ala Val Gln  Asn Trp Leu 
    3125                 3130                 3135             


Ala Arg  Val Gly Arg Glu Arg  Leu Ser Arg Met Ala  Ile Ser Gly 
    3140                 3145                 3150             


Asp Asp  Cys Val Val Lys Pro  Leu Asp Asp Arg Phe  Ala Ser Ala 
    3155                 3160                 3165             


Leu Thr  Ala Leu Asn Asp Met  Gly Lys Ile Arg Lys  Asp Ile Gln 
    3170                 3175                 3180             


Gln Trp  Glu Pro Ser Arg Gly  Trp Asn Asp Trp Thr  Gln Val Pro 
    3185                 3190                 3195             


Phe Cys  Ser His His Phe His  Glu Leu Ile Met Lys  Asp Gly Arg 
    3200                 3205                 3210             


Val Leu  Val Val Pro Cys Arg  Asn Gln Asp Glu Leu  Ile Gly Arg 
    3215                 3220                 3225             


Ala Arg  Ile Ser Gln Gly Ala  Gly Trp Ser Leu Arg  Glu Thr Ala 
    3230                 3235                 3240             


Cys Leu  Gly Lys Ser Tyr Ala  Gln Met Trp Ser Leu  Met Tyr Phe 
    3245                 3250                 3255             


His Arg  Arg Asp Leu Arg Leu  Ala Ala Asn Ala Ile  Cys Ser Ala 
    3260                 3265                 3270             


Val Pro  Ser His Trp Val Pro  Thr Ser Arg Thr Thr  Trp Ser Ile 
    3275                 3280                 3285             


His Ala  Lys His Glu Trp Met  Thr Thr Glu Asp Met  Leu Thr Val 
    3290                 3295                 3300             


Trp Asn  Arg Val Trp Ile Gln  Glu Asn Pro Trp Met  Glu Asp Lys 
    3305                 3310                 3315             


Thr Pro  Val Glu Ser Trp Glu  Glu Ile Pro Tyr Leu  Gly Lys Arg 
    3320                 3325                 3330             


Glu Asp  Gln Trp Cys Gly Ser  Leu Ile Gly Leu Thr  Ser Arg Ala 
    3335                 3340                 3345             


Thr Trp  Ala Lys Asn Ile Gln  Ala Ala Ile Asn Gln  Val Arg Ser 
    3350                 3355                 3360             


Leu Ile  Gly Asn Glu Glu Tyr  Thr Asp Tyr Met Pro  Ser Met Lys 
    3365                 3370                 3375             


Arg Phe  Arg Arg Glu Glu Glu  Glu Ala Gly Val Leu  Trp 
    3380                 3385                 3390     


<210>  12
<211>  3391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dengue virus serotype 4, MVS

<400>  12

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Ser Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Asp Gly Glu Pro Leu Met Ile Val 
        115                 120                 125             


Ala Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly 
    130                 135                 140                 


Ile Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Glu 
145                 150                 155                 160 


Asp Thr Val Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Met Tyr Gly 
            180                 185                 190         


Thr Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp 
225                 230                 235                 240 


Ile Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr 
                245                 250                 255     


Met Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu Met 
            260                 265                 270         


Met Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val Gly Val Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu Val 
    290                 295                 300                 


Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu Leu 
                325                 330                 335     


Arg Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln 
        355                 360                 365             


Gln Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe Ser 
385                 390                 395                 400 


Cys Ser Gly Lys Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu Glu 
                405                 410                 415     


Tyr Thr Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val Gly 
            420                 425                 430         


Asn Asp Thr Ser Asn His Gly Val Thr Ala Thr Ile Thr Pro Arg Ser 
        435                 440                 445             


Pro Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp 
    450                 455                 460                 


Cys Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys 
465                 470                 475                 480 


Met Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp Asn 
            500                 505                 510         


Tyr Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys Arg Gln 
        515                 520                 525             


Asp Val Thr Val Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala Leu 
    530                 535                 540                 


Ala Gly Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe Ala 
545                 550                 555                 560 


Gly His Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly 
                565                 570                 575     


Met Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly 
        595                 600                 605             


Ala Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys 
    610                 615                 620                 


Glu Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala Glu Asn 
625                 630                 635                 640 


Thr Asn Ser Val Thr Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser 
                645                 650                 655     


Tyr Ile Val Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp Phe 
            660                 665                 670         


Arg Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly 
        675                 680                 685             


Ala Lys Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln Val Phe 
705                 710                 715                 720 


Gly Ser Val Tyr Thr Thr Leu Phe Gly Gly Val Ser Trp Met Ile Arg 
                725                 730                 735     


Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg Asn 
            740                 745                 750         


Thr Ser Met Ala Met Thr Cys Ile Ala Ala Gly Ile Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 
    770                 775                 780                 


Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 
                805                 810                 815     


Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Asp Ile Cys Gly Ile 
            820                 825                 830         


Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 
        835                 840                 845             


Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 
    850                 855                 860                 


Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 
865                 870                 875                 880 


Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 
                885                 890                 895     


Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 
            900                 905                 910         


Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Asn Cys His Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Asn Leu Ala 
    1010                 1015                 1020             


Gly Pro  Val Ser Gln His Asn  Tyr Arg Pro Gly Tyr  His Thr Gln 
    1025                 1030                 1035             


Ile Thr  Gly Pro Trp His Leu  Gly Lys Leu Glu Met  Asp Phe Asp 
    1040                 1045                 1050             


Phe Cys  Asp Gly Thr Thr Val  Val Val Thr Glu Asp  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Ala Ser Gly  Lys Leu Ile 
    1070                 1075                 1080             


Thr Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr 
    1085                 1090                 1095             


Arg Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Leu 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Asn Ser Leu Val  Thr Ala Gly 
    1115                 1120                 1125             


His Gly  Gln Val Asp Asn Phe  Ser Leu Gly Val Leu  Gly Met Ala 
    1130                 1135                 1140             


Leu Phe  Leu Glu Glu Met Leu  Arg Thr Arg Val Gly  Thr Lys His 
    1145                 1150                 1155             


Ala Ile  Leu Leu Val Ala Val  Ser Phe Val Thr Leu  Ile Thr Gly 
    1160                 1165                 1170             


Asn Met  Ser Phe Arg Asp Leu  Gly Arg Val Met Val  Met Val Gly 
    1175                 1180                 1185             


Ala Thr  Met Thr Gly Asp Ile  Gly Met Gly Val Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Leu  Ala Ala Phe Lys Val  Arg Pro Thr Phe Ala  Ala Gly Leu 
    1205                 1210                 1215             


Leu Leu  Arg Lys Leu Thr Ser  Arg Glu Leu Met Met  Thr Thr Ile 
    1220                 1225                 1230             


Gly Ile  Val Leu Leu Ser Gln  Ser Thr Ile Pro Glu  Thr Ile Leu 
    1235                 1240                 1245             


Glu Leu  Thr Asp Ala Leu Ala  Leu Gly Met Met Val  Leu Lys Met 
    1250                 1255                 1260             


Val Arg  Asn Met Glu Lys Tyr  Gln Leu Ala Val Thr  Ile Met Ala 
    1265                 1270                 1275             


Ile Leu  Cys Val Pro Asn Ala  Val Ile Leu Gln Asn  Ala Trp Lys 
    1280                 1285                 1290             


Val Ser  Cys Thr Ile Leu Ala  Val Val Ser Val Ser  Pro Leu Phe 
    1295                 1300                 1305             


Leu Thr  Ser Ser Gln Gln Lys  Thr Asp Trp Ile Pro  Leu Ala Leu 
    1310                 1315                 1320             


Thr Ile  Lys Gly Leu Asn Pro  Thr Ala Ile Phe Leu  Thr Thr Leu 
    1325                 1330                 1335             


Ser Arg  Thr Ser Lys Lys Arg  Ser Trp Pro Leu Asn  Glu Ala Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Met Val Ser  Ile Leu Ala Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Ile Pro Met Thr Gly  Pro Leu Val Ala Gly  Gly Leu Leu 
    1370                 1375                 1380             


Thr Val  Cys Tyr Val Leu Thr  Gly Arg Ser Ala Asp  Leu Glu Leu 
    1385                 1390                 1395             


Glu Arg  Ala Ala Asp Val Lys  Trp Glu Asp Gln Ala  Glu Ile Ser 
    1400                 1405                 1410             


Gly Ser  Ser Pro Ile Leu Ser  Ile Thr Ile Ser Glu  Asp Gly Ser 
    1415                 1420                 1425             


Met Ser  Ile Lys Asn Glu Glu  Glu Glu Gln Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Ile Arg  Thr Gly Leu Leu Val  Ile Ser Gly Leu Phe  Pro Val Ser 
    1445                 1450                 1455             


Ile Pro  Ile Thr Ala Ala Ala  Trp Tyr Leu Trp Glu  Val Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ala Gly Val Leu Trp  Asp Val Pro Ser Pro  Pro Pro Met 
    1475                 1480                 1485             


Gly Lys  Ala Glu Leu Glu Asp  Gly Ala Tyr Arg Ile  Lys Gln Lys 
    1490                 1495                 1500             


Gly Ile  Leu Gly Tyr Ser Gln  Ile Gly Ala Gly Val  Tyr Lys Glu 
    1505                 1510                 1515             


Gly Thr  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met His  Lys Gly Lys Arg Ile  Glu Pro Ser Trp Ala  Asp Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Lys Leu  Glu Gly Glu 
    1550                 1555                 1560             


Trp Lys  Glu Gly Glu Glu Val  Gln Val Leu Ala Leu  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Arg Ala Val Gln  Thr Lys Pro Gly Leu  Phe Lys Thr 
    1580                 1585                 1590             


Asn Ala  Gly Thr Ile Gly Ala  Val Ser Leu Asp Phe  Ser Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Ile  Asp Lys Lys Gly Lys  Val Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Arg Ser Gly Ala  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Thr Glu Lys  Ser Ile Glu Asp Asn  Pro Glu Ile 
    1640                 1645                 1650             


Glu Asp  Asp Ile Phe Arg Lys  Arg Arg Leu Thr Ile  Met Asp Leu 
    1655                 1660                 1665             


His Pro  Gly Ala Gly Lys Thr  Lys Arg Tyr Leu Pro  Ala Ile Val 
    1670                 1675                 1680             


Arg Glu  Ala Ile Lys Arg Gly  Leu Arg Thr Leu Ile  Leu Ala Pro 
    1685                 1690                 1695             


Thr Arg  Val Val Ala Ala Glu  Met Glu Glu Ala Leu  Arg Gly Leu 
    1700                 1705                 1710             


Pro Ile  Arg Tyr Gln Thr Pro  Ala Ile Arg Ala Val  His Thr Gly 
    1715                 1720                 1725             


Arg Glu  Ile Val Asp Leu Met  Cys His Ala Thr Phe  Thr Met Arg 
    1730                 1735                 1740             


Leu Leu  Ser Pro Val Arg Val  Pro Asn Tyr Asn Leu  Ile Ile Met 
    1745                 1750                 1755             


Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly 
    1760                 1765                 1770             


Tyr Ile  Ser Thr Arg Val Glu  Met Gly Glu Ala Ala  Gly Ile Phe 
    1775                 1780                 1785             


Met Thr  Ala Thr Pro Pro Gly  Ser Arg Asp Pro Phe  Pro Gln Ser 
    1790                 1795                 1800             


Asn Ala  Pro Ile Ile Asp Glu  Glu Arg Glu Ile Pro  Glu Arg Ser 
    1805                 1810                 1815             


Trp Asn  Ser Gly His Glu Trp  Val Thr Asp Phe Lys  Gly Lys Thr 
    1820                 1825                 1830             


Val Trp  Phe Val Pro Ser Ile  Lys Ala Gly Asn Asp  Ile Ala Ala 
    1835                 1840                 1845             


Cys Leu  Arg Lys Asn Gly Lys  Lys Val Ile Gln Leu  Ser Arg Lys 
    1850                 1855                 1860             


Thr Phe  Asp Ser Glu Tyr Val  Lys Thr Arg Thr Asn  Asp Trp Asp 
    1865                 1870                 1875             


Phe Val  Val Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys 
    1880                 1885                 1890             


Ala Glu  Arg Val Ile Asp Pro  Arg Arg Cys Met Lys  Pro Val Ile 
    1895                 1900                 1905             


Leu Thr  Asp Gly Glu Glu Arg  Val Ile Leu Ala Gly  Pro Met Pro 
    1910                 1915                 1920             


Val Thr  His Ser Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg 
    1925                 1930                 1935             


Asn Pro  Lys Asn Glu Asn Asp  Gln Tyr Ile Tyr Met  Gly Glu Pro 
    1940                 1945                 1950             


Leu Glu  Asn Asp Glu Asp Cys  Ala His Trp Lys Glu  Ala Lys Met 
    1955                 1960                 1965             


Leu Leu  Asp Asn Ile Asn Thr  Pro Glu Gly Ile Ile  Pro Ser Met 
    1970                 1975                 1980             


Phe Glu  Pro Glu Arg Glu Lys  Val Asp Ala Ile Asp  Gly Glu Tyr 
    1985                 1990                 1995             


Arg Leu  Arg Gly Glu Ala Arg  Lys Thr Phe Val Asp  Leu Met Arg 
    2000                 2005                 2010             


Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr Arg Val  Ala Ala Glu 
    2015                 2020                 2025             


Gly Ile  Asn Tyr Ala Asp Arg  Arg Trp Cys Phe Asp  Gly Val Lys 
    2030                 2035                 2040             


Asn Asn  Gln Ile Leu Glu Glu  Asn Val Glu Val Glu  Ile Trp Thr 
    2045                 2050                 2055             


Lys Glu  Gly Glu Arg Lys Lys  Leu Lys Pro Arg Trp  Leu Asp Ala 
    2060                 2065                 2070             


Arg Ile  Tyr Ser Asp Pro Leu  Ala Leu Lys Glu Phe  Lys Glu Phe 
    2075                 2080                 2085             


Ala Ala  Gly Arg Lys Ser Leu  Thr Leu Asn Leu Ile  Thr Glu Met 
    2090                 2095                 2100             


Gly Arg  Leu Pro Thr Phe Met  Thr Gln Lys Val Arg  Asp Ala Leu 
    2105                 2110                 2115             


Asp Asn  Leu Ala Val Leu His  Thr Ala Glu Ala Gly  Gly Arg Ala 
    2120                 2125                 2130             


Tyr Asn  His Ala Leu Ser Glu  Leu Pro Glu Thr Leu  Glu Thr Leu 
    2135                 2140                 2145             


Leu Leu  Leu Thr Leu Leu Ala  Thr Val Thr Gly Gly  Ile Phe Leu 
    2150                 2155                 2160             


Phe Leu  Met Ser Ala Arg Gly  Ile Gly Lys Met Thr  Leu Gly Met 
    2165                 2170                 2175             


Cys Cys  Ile Ile Thr Ala Ser  Ile Leu Leu Trp Tyr  Ala Gln Ile 
    2180                 2185                 2190             


Gln Pro  His Trp Ile Ala Ala  Ser Ile Ile Leu Glu  Phe Phe Leu 
    2195                 2200                 2205             


Ile Val  Leu Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Thr Pro Gln 
    2210                 2215                 2220             


Asp Asn  Gln Leu Thr Tyr Val  Val Ile Ala Ile Leu  Thr Val Val 
    2225                 2230                 2235             


Ala Ala  Thr Met Ala Asn Glu  Met Gly Phe Leu Glu  Lys Thr Lys 
    2240                 2245                 2250             


Lys Asp  Leu Gly Leu Gly Ser  Ile Ala Thr Gln Gln  Pro Glu Ser 
    2255                 2260                 2265             


Asn Ile  Leu Asp Ile Asp Leu  Arg Pro Ala Ser Ala  Trp Thr Leu 
    2270                 2275                 2280             


Tyr Ala  Val Ala Thr Thr Phe  Val Thr Pro Met Leu  Arg His Ser 
    2285                 2290                 2295             


Ile Glu  Asn Ser Ser Val Asn  Val Ser Leu Thr Ala  Ile Ala Asn 
    2300                 2305                 2310             


Gln Ala  Thr Val Leu Met Gly  Leu Gly Lys Gly Trp  Pro Leu Ser 
    2315                 2320                 2325             


Lys Met  Asp Ile Gly Val Pro  Leu Leu Ala Ile Gly  Cys Tyr Ser 
    2330                 2335                 2340             


Gln Val  Asn Pro Ile Thr Leu  Thr Ala Ala Leu Phe  Leu Leu Val 
    2345                 2350                 2355             


Ala His  Tyr Ala Ile Ile Gly  Pro Gly Leu Gln Ala  Lys Ala Thr 
    2360                 2365                 2370             


Arg Glu  Ala Gln Lys Arg Ala  Ala Ala Gly Ile Met  Lys Asn Pro 
    2375                 2380                 2385             


Thr Val  Asp Gly Ile Thr Val  Ile Asp Leu Asp Pro  Ile Pro Tyr 
    2390                 2395                 2400             


Asp Pro  Lys Phe Glu Lys Gln  Leu Gly Gln Val Met  Leu Leu Val 
    2405                 2410                 2415             


Leu Cys  Val Thr Gln Val Leu  Met Met Arg Thr Thr  Trp Ala Leu 
    2420                 2425                 2430             


Cys Glu  Ala Leu Thr Leu Ala  Thr Gly Pro Ile Ser  Thr Leu Trp 
    2435                 2440                 2445             


Glu Gly  Asn Pro Gly Arg Phe  Trp Asn Thr Thr Ile  Ala Val Ser 
    2450                 2455                 2460             


Met Ala  Asn Ile Phe Arg Gly  Ser Tyr Leu Ala Gly  Ala Gly Leu 
    2465                 2470                 2475             


Leu Phe  Ser Ile Met Lys Asn  Thr Thr Asn Thr Arg  Arg Gly Thr 
    2480                 2485                 2490             


Gly Asn  Ile Gly Glu Thr Leu  Gly Glu Lys Trp Lys  Ser Arg Leu 
    2495                 2500                 2505             


Asn Ala  Leu Gly Lys Ser Glu  Phe Gln Ile Tyr Lys  Lys Ser Gly 
    2510                 2515                 2520             


Ile Gln  Glu Val Asp Arg Thr  Leu Ala Lys Glu Gly  Ile Lys Arg 
    2525                 2530                 2535             


Gly Glu  Thr Asp His His Ala  Val Ser Arg Gly Ser  Ala Lys Leu 
    2540                 2545                 2550             


Arg Trp  Phe Val Glu Arg Asn  Met Val Thr Pro Glu  Gly Lys Val 
    2555                 2560                 2565             


Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp Ser Tyr  Tyr Cys Gly 
    2570                 2575                 2580             


Gly Leu  Lys Asn Val Arg Glu  Val Lys Gly Leu Thr  Lys Gly Gly 
    2585                 2590                 2595             


Pro Gly  His Glu Glu Pro Ile  Pro Met Ser Thr Tyr  Gly Trp Asn 
    2600                 2605                 2610             


Leu Val  Arg Leu Gln Ser Gly  Val Asp Val Phe Phe  Ile Pro Pro 
    2615                 2620                 2625             


Glu Lys  Cys Asp Thr Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Pro 
    2630                 2635                 2640             


Asn Pro  Thr Val Glu Ala Gly  Arg Thr Leu Arg Val  Leu Asn Leu 
    2645                 2650                 2655             


Val Glu  Asn Trp Leu Asn Asn  Asn Thr Gln Phe Cys  Ile Lys Val 
    2660                 2665                 2670             


Leu Asn  Pro Tyr Met Pro Ser  Val Ile Glu Lys Met  Glu Ala Leu 
    2675                 2680                 2685             


Gln Arg  Lys Tyr Gly Gly Ala  Leu Val Arg Asn Pro  Leu Ser Arg 
    2690                 2695                 2700             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Asn Ala  Ser Gly Asn 
    2705                 2710                 2715             


Ile Val  Ser Ser Val Asn Met  Ile Ser Arg Met Leu  Ile Asn Arg 
    2720                 2725                 2730             


Phe Thr  Met Arg Tyr Lys Lys  Ala Thr Tyr Glu Pro  Asp Val Asp 
    2735                 2740                 2745             


Leu Gly  Ser Gly Thr Arg Asn  Ile Gly Ile Glu Ser  Glu Ile Pro 
    2750                 2755                 2760             


Asn Leu  Asp Ile Ile Gly Lys  Arg Ile Glu Lys Ile  Lys Gln Glu 
    2765                 2770                 2775             


His Glu  Thr Ser Trp His Tyr  Asp Gln Asp His Pro  Tyr Lys Thr 
    2780                 2785                 2790             


Trp Ala  Tyr His Gly Ser Tyr  Glu Thr Lys Gln Thr  Gly Ser Ala 
    2795                 2800                 2805             


Ser Ser  Met Val Asn Gly Val  Val Arg Leu Leu Thr  Lys Pro Trp 
    2810                 2815                 2820             


Asp Val  Val Pro Met Val Thr  Gln Met Ala Met Thr  Asp Thr Thr 
    2825                 2830                 2835             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2840                 2845                 2850             


Thr Gln  Glu Pro Lys Glu Gly  Thr Lys Lys Leu Met  Lys Ile Thr 
    2855                 2860                 2865             


Ala Glu  Trp Leu Trp Lys Glu  Leu Gly Lys Lys Lys  Thr Pro Arg 
    2870                 2875                 2880             


Met Cys  Thr Arg Glu Glu Phe  Thr Arg Lys Val Arg  Ser Asn Ala 
    2885                 2890                 2895             


Ala Leu  Gly Ala Ile Phe Thr  Asp Glu Asn Lys Trp  Lys Ser Ala 
    2900                 2905                 2910             


Arg Glu  Ala Val Glu Asp Ser  Arg Phe Trp Glu Leu  Val Asp Lys 
    2915                 2920                 2925             


Glu Arg  Asn Leu His Leu Glu  Gly Lys Cys Glu Thr  Cys Val Tyr 
    2930                 2935                 2940             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Leu Gly Glu  Phe Gly Lys 
    2945                 2950                 2955             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2960                 2965                 2970             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    2975                 2980                 2985             


Phe Ser  Arg Glu Asn Ser Leu  Ser Gly Val Glu Gly  Glu Gly Leu 
    2990                 2995                 3000             


His Lys  Leu Gly Tyr Ile Leu  Arg Asp Val Ser Lys  Lys Glu Gly 
    3005                 3010                 3015             


Gly Ala  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3020                 3025                 3030             


Thr Leu  Glu Asp Leu Lys Asn  Glu Glu Met Val Thr  Asn His Met 
    3035                 3040                 3045             


Glu Gly  Glu His Lys Lys Leu  Ala Glu Ala Ile Phe  Lys Leu Thr 
    3050                 3055                 3060             


Tyr Gln  Asn Lys Val Val Arg  Val Gln Arg Pro Thr  Pro Arg Gly 
    3065                 3070                 3075             


Thr Val  Met Asp Ile Ile Ser  Arg Arg Asp Gln Arg  Gly Ser Gly 
    3080                 3085                 3090             


Gln Val  Gly Thr Tyr Gly Leu  Asn Thr Phe Thr Asn  Met Glu Ala 
    3095                 3100                 3105             


Gln Leu  Ile Arg Gln Met Glu  Gly Glu Gly Val Phe  Lys Ser Ile 
    3110                 3115                 3120             


Gln His  Leu Thr Ile Thr Glu  Glu Ile Ala Val Gln  Asn Trp Leu 
    3125                 3130                 3135             


Ala Arg  Val Gly Arg Glu Arg  Leu Ser Arg Met Ala  Ile Ser Gly 
    3140                 3145                 3150             


Asp Asp  Cys Val Val Lys Pro  Leu Asp Asp Arg Phe  Ala Ser Ala 
    3155                 3160                 3165             


Leu Thr  Ala Leu Asn Asp Met  Gly Lys Ile Arg Lys  Asp Ile Gln 
    3170                 3175                 3180             


Gln Trp  Glu Pro Ser Arg Gly  Trp Asn Asp Trp Thr  Gln Val Pro 
    3185                 3190                 3195             


Phe Cys  Ser His His Phe His  Glu Leu Ile Met Lys  Asp Gly Arg 
    3200                 3205                 3210             


Val Leu  Val Val Pro Cys Arg  Asn Gln Asp Glu Leu  Ile Gly Arg 
    3215                 3220                 3225             


Ala Arg  Ile Ser Gln Gly Ala  Gly Trp Ser Leu Arg  Glu Thr Ala 
    3230                 3235                 3240             


Cys Leu  Gly Lys Ser Tyr Ala  Gln Met Trp Ser Leu  Met Tyr Phe 
    3245                 3250                 3255             


His Arg  Arg Asp Leu Arg Leu  Ala Ala Asn Ala Ile  Cys Ser Ala 
    3260                 3265                 3270             


Val Pro  Ser His Trp Val Pro  Thr Ser Arg Thr Thr  Trp Ser Ile 
    3275                 3280                 3285             


His Ala  Lys His Glu Trp Met  Thr Thr Glu Asp Met  Leu Thr Val 
    3290                 3295                 3300             


Trp Asn  Arg Val Trp Ile Gln  Glu Asn Pro Trp Met  Glu Asp Lys 
    3305                 3310                 3315             


Thr Pro  Val Glu Ser Trp Glu  Glu Ile Pro Tyr Leu  Gly Lys Arg 
    3320                 3325                 3330             


Glu Asp  Gln Trp Cys Gly Ser  Leu Ile Gly Leu Thr  Ser Arg Ala 
    3335                 3340                 3345             


Thr Trp  Ala Lys Asn Ile Gln  Ala Ala Ile Asn Gln  Val Arg Ser 
    3350                 3355                 3360             


Leu Ile  Gly Asn Glu Glu Tyr  Thr Asp Tyr Met Pro  Ser Met Lys 
    3365                 3370                 3375             


Arg Phe  Arg Arg Glu Glu Glu  Glu Ala Gly Val Leu  Trp 
    3380                 3385                 3390     


