                               SEQUENCE LISTING

<110> COLLIER, BRUCE
      WANG, DAN
 
<120> GLUTAMATE OXIDASE MUTAGENESIS FOR DIAGNOSTIC TESTING

<130> 215105.07000

<140>
<141>

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 2147
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(2139)

<400> 1
agc tgg tac cat atg aac gac atc cgt ccg ggt cac cgt cgt gaa ccg         48
Ser Trp Tyr His Met Asn Asp Ile Arg Pro Gly His Arg Arg Glu Pro           
1               5                   10                  15                

tcc ggt gct gaa cgt gct gct gct aaa acc tgc cag cag ctg gct cgt         96
Ser Gly Ala Glu Arg Ala Ala Ala Lys Thr Cys Gln Gln Leu Ala Arg           
            20                  25                  30                    

gaa ctg ctg ctg gtt ggt ccg gaa ccg gct aac gaa gac ctg aaa ctg        144
Glu Leu Leu Leu Val Gly Pro Glu Pro Ala Asn Glu Asp Leu Lys Leu           
        35                  40                  45                        

cgt tac ctg gac gtt ctg atc gac aac ggt ctg gaa ccg acc gct gac        192
Arg Tyr Leu Asp Val Leu Ile Asp Asn Gly Leu Glu Pro Thr Ala Asp           
    50                  55                  60                            

ccg aaa cgt atc ctg atc gtt ggt gct ggt atc gct ggt ctg gtt gct        240
Pro Lys Arg Ile Leu Ile Val Gly Ala Gly Ile Ala Gly Leu Val Ala           
65                  70                  75                  80            

ggt gac ctg ctg acc cgt gct ggt cac gaa gtt acc atc ctg gaa gct        288
Gly Asp Leu Leu Thr Arg Ala Gly His Glu Val Thr Ile Leu Glu Ala           
                85                  90                  95                

aac gct aac cgt gtt ggt ggt cgt atc aaa acc ttc cac gct aaa aaa        336
Asn Ala Asn Arg Val Gly Gly Arg Ile Lys Thr Phe His Ala Lys Lys           
            100                 105                 110                   

ggt gaa ccg ccg ccg ttc acc gac ccg gct cag tac gct gaa gct ggt        384
Gly Glu Pro Pro Pro Phe Thr Asp Pro Ala Gln Tyr Ala Glu Ala Gly           
        115                 120                 125                       

gct atg cgt ctg ccg tcc ttc cac ccg ctg acc ctg gct ctg atc gac        432
Ala Met Arg Leu Pro Ser Phe His Pro Leu Thr Leu Ala Leu Ile Asp           
    130                 135                 140                           

aaa ctg ggt ctg aaa cgt cgt ctg ttc ttc aac gtt gac atc gac ccg        480
Lys Leu Gly Leu Lys Arg Arg Leu Phe Phe Asn Val Asp Ile Asp Pro           
145                 150                 155                 160           

gct acc ggt aac cag aac gct ccg ctg ccg ccg gtt gtt tac aaa tcc        528
Ala Thr Gly Asn Gln Asn Ala Pro Leu Pro Pro Val Val Tyr Lys Ser           
                165                 170                 175               

ttc aaa gac ggt aaa gtt tgg acc aac ggt gct ccg tcc ccg gag ttc        576
Phe Lys Asp Gly Lys Val Trp Thr Asn Gly Ala Pro Ser Pro Glu Phe           
            180                 185                 190                   

cgt gct ccg gac aaa cgt aac cac acc tgg atc cgt acc aac cgt acc        624
Arg Ala Pro Asp Lys Arg Asn His Thr Trp Ile Arg Thr Asn Arg Thr           
        195                 200                 205                       

cag gtt cgt cgt gct cag tac gct aaa gac ccg tcc gct atc aac gaa        672
Gln Val Arg Arg Ala Gln Tyr Ala Lys Asp Pro Ser Ala Ile Asn Glu           
    210                 215                 220                           

ggt ttc cac ctg acc ggt tcc gct tcc cgt ctg ccg gtt gct gaa atg        720
Gly Phe His Leu Thr Gly Ser Ala Ser Arg Leu Pro Val Ala Glu Met           
225                 230                 235                 240           

gtt cac cag gct ctg gaa ccg gtt cgt gac tac tac tcc gtt ctg cag        768
Val His Gln Ala Leu Glu Pro Val Arg Asp Tyr Tyr Ser Val Leu Gln           
                245                 250                 255               

tcc gac ggc acc cgt gtt aac aaa ccg ttc cag gaa tgg ctg gac ggt        816
Ser Asp Gly Thr Arg Val Asn Lys Pro Phe Gln Glu Trp Leu Asp Gly           
            260                 265                 270                   

tgg gct gaa gtt atc cgt gac ttc gac ggt tac tcc atg ggt cgt ttc        864
Trp Ala Glu Val Ile Arg Asp Phe Asp Gly Tyr Ser Met Gly Arg Phe           
        275                 280                 285                       

ctg cgt gaa tac gct ggt ctg tcc gac gaa gct atc gaa gct atc ggc        912
Leu Arg Glu Tyr Ala Gly Leu Ser Asp Glu Ala Ile Glu Ala Ile Gly           
    290                 295                 300                           

acc atc gaa aac atg acc tcc cgt ctg cac ctg gct ttc ttc cac tcc        960
Thr Ile Glu Asn Met Thr Ser Arg Leu His Leu Ala Phe Phe His Ser           
305                 310                 315                 320           

ttc ctg ggt cgt tcc gac atc gac ccg acc gct acc tac tgg gaa atc       1008
Phe Leu Gly Arg Ser Asp Ile Asp Pro Thr Ala Thr Tyr Trp Glu Ile           
                325                 330                 335               

gaa ggt ggt tcc cgt cgt ctg ccg gaa gct ctg gct aaa gac ctg cgt       1056
Glu Gly Gly Ser Arg Arg Leu Pro Glu Ala Leu Ala Lys Asp Leu Arg           
            340                 345                 350                   

gac cag atc gtt atg ggt cgt cgt atg gtt cgt ctg gaa tac tac gat       1104
Asp Gln Ile Val Met Gly Arg Arg Met Val Arg Leu Glu Tyr Tyr Asp           
        355                 360                 365                       

ccg ggt cgt gac ggt cac cag ggc acc ctg gct ggt ccg ggt ggt ccg       1152
Pro Gly Arg Asp Gly His Gln Gly Thr Leu Ala Gly Pro Gly Gly Pro           
    370                 375                 380                           

gct gtt gct atc cag acc gtt ccg gaa ggt gac ccg tac ggt gaa ccg       1200
Ala Val Ala Ile Gln Thr Val Pro Glu Gly Asp Pro Tyr Gly Glu Pro           
385                 390                 395                 400           

cag acc tgg acc ggt gac ctg gct atc gtt acc atc ccg ttc gct tcc       1248
Gln Thr Trp Thr Gly Asp Leu Ala Ile Val Thr Ile Pro Phe Ala Ser           
                405                 410                 415               

ctg cgt ttc acc acc gtt acc ccg ccg ttc tcc tac aaa aaa cgt cgt       1296
Leu Arg Phe Thr Thr Val Thr Pro Pro Phe Ser Tyr Lys Lys Arg Arg           
            420                 425                 430                   

gct gtt atc gaa acc cac tac gac cag gct acc aaa gtt ctg ctg gag       1344
Ala Val Ile Glu Thr His Tyr Asp Gln Ala Thr Lys Val Leu Leu Glu           
        435                 440                 445                       

ttc tcc cgt cgt tgg tgg gag ttc acc gaa gct gac tgg aaa cgt gaa       1392
Phe Ser Arg Arg Trp Trp Glu Phe Thr Glu Ala Asp Trp Lys Arg Glu           
    450                 455                 460                           

ctg gac acc atc gct ccg ggt ctg tac gaa tac tac cag cag tgg ggt       1440
Leu Asp Thr Ile Ala Pro Gly Leu Tyr Glu Tyr Tyr Gln Gln Trp Gly           
465                 470                 475                 480           

gaa gac gac gct gaa gct gct gtt tcc gtt ccg cag cac ctg cgt gac       1488
Glu Asp Asp Ala Glu Ala Ala Val Ser Val Pro Gln His Leu Arg Asp           
                485                 490                 495               

ctg ccg acc ggt ctg ctg ggt gct cac ccg tcc gtt gac gaa aaa cgt       1536
Leu Pro Thr Gly Leu Leu Gly Ala His Pro Ser Val Asp Glu Lys Arg           
            500                 505                 510                   

atc ggt cag gaa cag gtt gaa tac tac cgt aac tcc tcc ctg cgt ggt       1584
Ile Gly Gln Glu Gln Val Glu Tyr Tyr Arg Asn Ser Ser Leu Arg Gly           
        515                 520                 525                       

ggt gtt cgt ccg gct acc cac gct gtt ggt ggt ggt tcc acc acc gac       1632
Gly Val Arg Pro Ala Thr His Ala Val Gly Gly Gly Ser Thr Thr Asp           
    530                 535                 540                           

aac ccg aac cgt ttc atg tac tac ccg tcc cac ccg gtt ccg ggt tcc       1680
Asn Pro Asn Arg Phe Met Tyr Tyr Pro Ser His Pro Val Pro Gly Ser           
545                 550                 555                 560           

tcc ggt ggt gtt gtt ctg gct ggt tac tcc tgg tcc gac gac gct gct       1728
Ser Gly Gly Val Val Leu Ala Gly Tyr Ser Trp Ser Asp Asp Ala Ala           
                565                 570                 575               

cgt tgg gac tcc ttc gac gac gct gaa cgt tac tcc tac gct ctg ctg       1776
Arg Trp Asp Ser Phe Asp Asp Ala Glu Arg Tyr Ser Tyr Ala Leu Leu           
            580                 585                 590                   

aac ctg cag tcc gtt cac ggt cgt cgt atc gaa gtt ttc tac acc ggt       1824
Asn Leu Gln Ser Val His Gly Arg Arg Ile Glu Val Phe Tyr Thr Gly           
        595                 600                 605                       

gct ggt cag acc cag tcc tgg ctg cgt gac ccg tac gct tgc ggt gaa       1872
Ala Gly Gln Thr Gln Ser Trp Leu Arg Asp Pro Tyr Ala Cys Gly Glu           
    610                 615                 620                           

gct gct gtt tac acc ccg cac cag atg acc tcc ttc cac ctg gac gct       1920
Ala Ala Val Tyr Thr Pro His Gln Met Thr Ser Phe His Leu Asp Ala           
625                 630                 635                 640           

gtt cgt gct gaa ggt ccg gtt cac ttc gct ggt gaa cac gtt tcc ctg       1968
Val Arg Ala Glu Gly Pro Val His Phe Ala Gly Glu His Val Ser Leu           
                645                 650                 655               

aaa cac gct tgg atc gaa ggt gct gtt gaa acc gct gtt cgt gct gct       2016
Lys His Ala Trp Ile Glu Gly Ala Val Glu Thr Ala Val Arg Ala Ala           
            660                 665                 670                   

ctg gct gtt cac gaa tcc ccg gct gct tgc gaa tcc gct gct gct gct       2064
Leu Ala Val His Glu Ser Pro Ala Ala Cys Glu Ser Ala Ala Ala Ala           
        675                 680                 685                       

cgt acc gct gaa ccg ggt gaa tcc cgt gct gac gct acc ccg ccg gct       2112
Arg Thr Ala Glu Pro Gly Glu Ser Arg Ala Asp Ala Thr Pro Pro Ala           
    690                 695                 700                           

ccg tcc cag gaa gac gtt gtt acc tcc tgaagctt                          2147
Pro Ser Gln Glu Asp Val Val Thr Ser                                       
705                 710                                                   


<210> 2
<211> 10
<212> PRT
<213> Streptomyces griseus

<400> 2
Ser Phe Arg Ala Pro Asp Ser Asp Asp Arg 
1               5                   10  


<210> 3
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Glu or Asp

<400> 3
Ile Xaa Gly Arg 
1               


<210> 4
<211> 2207
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(2199)

<400> 4
cgg gat ccg agc tgg tac cat atg aac gac atc cgt ccg ggt cac cgt         48
Arg Asp Pro Ser Trp Tyr His Met Asn Asp Ile Arg Pro Gly His Arg           
1               5                   10                  15                

cgt gaa ccg tcc ggt gct gaa cgt gct gat atc gaa gcc cgc gct gct         96
Arg Glu Pro Ser Gly Ala Glu Arg Ala Asp Ile Glu Ala Arg Ala Ala           
            20                  25                  30                    

aaa acc tgc cag cag ctg gct cgt gaa ctg ctg ctg gtt ggt ccg gaa        144
Lys Thr Cys Gln Gln Leu Ala Arg Glu Leu Leu Leu Val Gly Pro Glu           
        35                  40                  45                        

ccg gct aac gaa gac ctg aaa ctg cgt tac ctg gac gtt ctg atc gac        192
Pro Ala Asn Glu Asp Leu Lys Leu Arg Tyr Leu Asp Val Leu Ile Asp           
    50                  55                  60                            

aac ggt ctg gaa ccg acc gct gac ccg aaa cgt atc ctg atc gtt ggt        240
Asn Gly Leu Glu Pro Thr Ala Asp Pro Lys Arg Ile Leu Ile Val Gly           
65                  70                  75                  80            

gct ggt atc gct ggt ctg gtt gct ggt gac ctg ctg acc cgt gct ggt        288
Ala Gly Ile Ala Gly Leu Val Ala Gly Asp Leu Leu Thr Arg Ala Gly           
                85                  90                  95                

cac gaa gtt acc atc ctg gaa gct aac gct aac cgt gtt ggt ggt cgt        336
His Glu Val Thr Ile Leu Glu Ala Asn Ala Asn Arg Val Gly Gly Arg           
            100                 105                 110                   

atc aaa acc ttc cac gct aaa aaa ggt gaa ccg ccg ccg ttc acc gac        384
Ile Lys Thr Phe His Ala Lys Lys Gly Glu Pro Pro Pro Phe Thr Asp           
        115                 120                 125                       

ccg gct cag tac gct gaa gct ggt gct atg cgt ctg ccg tcc ttc cac        432
Pro Ala Gln Tyr Ala Glu Ala Gly Ala Met Arg Leu Pro Ser Phe His           
    130                 135                 140                           

ccg ctg acc ctg gct ctg atc gac aaa ctg ggt ctg aaa cgt cgt ctg        480
Pro Leu Thr Leu Ala Leu Ile Asp Lys Leu Gly Leu Lys Arg Arg Leu           
145                 150                 155                 160           

ttc ttc aac gtt gac atc gac ccg gct acc ggt aac cag aac gct ccg        528
Phe Phe Asn Val Asp Ile Asp Pro Ala Thr Gly Asn Gln Asn Ala Pro           
                165                 170                 175               

ctg ccg ccg gtt gtt tac aaa tcc ttc aaa gac ggt aaa gtt tgg acc        576
Leu Pro Pro Val Val Tyr Lys Ser Phe Lys Asp Gly Lys Val Trp Thr           
            180                 185                 190                   

aac ggt gct ccg tcc ccg gag ttc cgt gct ccg gac aaa cgt aac cac        624
Asn Gly Ala Pro Ser Pro Glu Phe Arg Ala Pro Asp Lys Arg Asn His           
        195                 200                 205                       

acc tgg atc cgt acc aac cgt acc cag gtt cgt cgt gct cag tac gct        672
Thr Trp Ile Arg Thr Asn Arg Thr Gln Val Arg Arg Ala Gln Tyr Ala           
    210                 215                 220                           

aaa gac ccg tcc gct atc aac gaa ggt ttc cac ctg acc ggt tcc gct        720
Lys Asp Pro Ser Ala Ile Asn Glu Gly Phe His Leu Thr Gly Ser Ala           
225                 230                 235                 240           

tcc cgt ctg ccg gtt gct gaa atg gtt cac cag gct ctg gaa ccg gtt        768
Ser Arg Leu Pro Val Ala Glu Met Val His Gln Ala Leu Glu Pro Val           
                245                 250                 255               

cgt gac tac tac tcc gtt ctg cag tcc gac ggc acc cgt gtt aac aaa        816
Arg Asp Tyr Tyr Ser Val Leu Gln Ser Asp Gly Thr Arg Val Asn Lys           
            260                 265                 270                   

ccg ttc cag gaa tgg ctg gac ggt tgg gct gaa gtt atc cgt gac ttc        864
Pro Phe Gln Glu Trp Leu Asp Gly Trp Ala Glu Val Ile Arg Asp Phe           
        275                 280                 285                       

gac ggt tac tcc atg ggt cgt ttc ctg cgt gaa tac gct ggt ctg tcc        912
Asp Gly Tyr Ser Met Gly Arg Phe Leu Arg Glu Tyr Ala Gly Leu Ser           
    290                 295                 300                           

gac gaa gct atc gaa gct atc ggc acc atc gaa aac atg acc tcc cgt        960
Asp Glu Ala Ile Glu Ala Ile Gly Thr Ile Glu Asn Met Thr Ser Arg           
305                 310                 315                 320           

ctg cac ctg gct ttc ttc cac tcc ttc ctg ggt cgt tcc gac atc gac       1008
Leu His Leu Ala Phe Phe His Ser Phe Leu Gly Arg Ser Asp Ile Asp           
                325                 330                 335               

ccg acc gct acc tac tgg gaa atc gaa ggt ggt tcc cgt cgt ctg ccg       1056
Pro Thr Ala Thr Tyr Trp Glu Ile Glu Gly Gly Ser Arg Arg Leu Pro           
            340                 345                 350                   

gaa gct ctg gct aaa gac ctg cgt gac cag atc gtt atg ggt cgt cgt       1104
Glu Ala Leu Ala Lys Asp Leu Arg Asp Gln Ile Val Met Gly Arg Arg           
        355                 360                 365                       

atg gtt cgt ctg gaa tac tac gat ccg ggt cgt gac ggt cac cag ggc       1152
Met Val Arg Leu Glu Tyr Tyr Asp Pro Gly Arg Asp Gly His Gln Gly           
    370                 375                 380                           

acc ctg gct att gac gct cgt gtc gac ggt ccg ggt ggt ccg gct gtt       1200
Thr Leu Ala Ile Asp Ala Arg Val Asp Gly Pro Gly Gly Pro Ala Val           
385                 390                 395                 400           

gct atc cag acc gtt ccg gaa ggt gac ccg tac ggt gaa ccg cag acc       1248
Ala Ile Gln Thr Val Pro Glu Gly Asp Pro Tyr Gly Glu Pro Gln Thr           
                405                 410                 415               

tgg acc ggt gac ctg gct atc gtt acc atc ccg ttc gct tcc ctg cgt       1296
Trp Thr Gly Asp Leu Ala Ile Val Thr Ile Pro Phe Ala Ser Leu Arg           
            420                 425                 430                   

ttc acc acc gtt acc ccg ccg ttc tcc tac aaa aaa cgt cgt gct gtt       1344
Phe Thr Thr Val Thr Pro Pro Phe Ser Tyr Lys Lys Arg Arg Ala Val           
        435                 440                 445                       

atc gaa acc cac tac gac cag gct acc aaa gtt ctg ctg gag ttc tcc       1392
Ile Glu Thr His Tyr Asp Gln Ala Thr Lys Val Leu Leu Glu Phe Ser           
    450                 455                 460                           

cgt cgt tgg tgg gag ttc acc gaa gct gac tgg aaa cgt gaa ctg gac       1440
Arg Arg Trp Trp Glu Phe Thr Glu Ala Asp Trp Lys Arg Glu Leu Asp           
465                 470                 475                 480           

acc atc gct ccg ggt ctg tac gaa tac tac cag cag tgg ggt gaa gac       1488
Thr Ile Ala Pro Gly Leu Tyr Glu Tyr Tyr Gln Gln Trp Gly Glu Asp           
                485                 490                 495               

gac gct gaa gct gct gtt tcc gtt ccg cag cac ctg cgt gac ctg ccg       1536
Asp Ala Glu Ala Ala Val Ser Val Pro Gln His Leu Arg Asp Leu Pro           
            500                 505                 510                   

acc ggt ctg ctg ggt gct cac ccg tcc gtt gac gaa aaa cgt atc ggt       1584
Thr Gly Leu Leu Gly Ala His Pro Ser Val Asp Glu Lys Arg Ile Gly           
        515                 520                 525                       

cag gaa cag gtt gaa tac tac cgt aac tcc tcc ctg cgt atc gag gcc       1632
Gln Glu Gln Val Glu Tyr Tyr Arg Asn Ser Ser Leu Arg Ile Glu Ala           
    530                 535                 540                           

cgt gaa ttc ggt ggt gtt cgt ccg gct acc cac gct gtt ggt ggt ggt       1680
Arg Glu Phe Gly Gly Val Arg Pro Ala Thr His Ala Val Gly Gly Gly           
545                 550                 555                 560           

tcc acc acc gac aac ccg aac cgt ttc atg tac tac ccg tcc cac ccg       1728
Ser Thr Thr Asp Asn Pro Asn Arg Phe Met Tyr Tyr Pro Ser His Pro           
                565                 570                 575               

gtt ccg ggt tcc tcc ggt ggt gtt gtt ctg gct ggt tac tcc tgg tcc       1776
Val Pro Gly Ser Ser Gly Gly Val Val Leu Ala Gly Tyr Ser Trp Ser           
            580                 585                 590                   

gac gac gct gct cgt tgg gac tcc ttc gac gac gct gaa cgt tac tcc       1824
Asp Asp Ala Ala Arg Trp Asp Ser Phe Asp Asp Ala Glu Arg Tyr Ser           
        595                 600                 605                       

tac gct ctg ctg aac ctg cag tcc gtt cac ggt cgt cgt atc gaa gtt       1872
Tyr Ala Leu Leu Asn Leu Gln Ser Val His Gly Arg Arg Ile Glu Val           
    610                 615                 620                           

ttc tac acc ggt gct ggt cag acc cag tcc tgg ctg cgt gac ccg tac       1920
Phe Tyr Thr Gly Ala Gly Gln Thr Gln Ser Trp Leu Arg Asp Pro Tyr           
625                 630                 635                 640           

gct tgc ggt gaa gct gct gtt tac acc ccg cac cag atg acc tcc ttc       1968
Ala Cys Gly Glu Ala Ala Val Tyr Thr Pro His Gln Met Thr Ser Phe           
                645                 650                 655               

cac ctg gac gct gtt cgt gct gaa ggt ccg gtt cac ttc gct ggt gaa       2016
His Leu Asp Ala Val Arg Ala Glu Gly Pro Val His Phe Ala Gly Glu           
            660                 665                 670                   

cac gtt tcc ctg aaa cac gct tgg atc gaa ggt gct gtt gaa acc gct       2064
His Val Ser Leu Lys His Ala Trp Ile Glu Gly Ala Val Glu Thr Ala           
        675                 680                 685                       

gtt cgt gct gct ctg gct gtt cac gaa tcc ccg gct gct tgc gaa tcc       2112
Val Arg Ala Ala Leu Ala Val His Glu Ser Pro Ala Ala Cys Glu Ser           
    690                 695                 700                           

gct gct gct gct cgt acc gct gaa ccg ggt gaa tcc cgt gct gac gct       2160
Ala Ala Ala Ala Arg Thr Ala Glu Pro Gly Glu Ser Arg Ala Asp Ala           
705                 710                 715                 720           

acc ccg ccg gct ccg tcc cag gaa gac gtt gtt acc tcc tgaagctt          2207
Thr Pro Pro Ala Pro Ser Gln Glu Asp Val Val Thr Ser                       
                725                 730                                   


<210> 5
<211> 2127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(2127)

<400> 5
cat atg aat tcg atg acc acc gat acc gcg cgc cgc cat acc ggc gcg         48
His Met Asn Ser Met Thr Thr Asp Thr Ala Arg Arg His Thr Gly Ala           
1               5                   10                  15                

gaa cgc gcg aac gaa atg acc tat gaa cag ctg gcg cgc gaa ctg ctg         96
Glu Arg Ala Asn Glu Met Thr Tyr Glu Gln Leu Ala Arg Glu Leu Leu           
            20                  25                  30                    

ctg gtg ggc ccg gcg ccg acc aac gaa gat ctg aaa ctg cgc tat ctg        144
Leu Val Gly Pro Ala Pro Thr Asn Glu Asp Leu Lys Leu Arg Tyr Leu           
        35                  40                  45                        

gat gtg ctg att gat aac ggc ctg aac ccg ccg ggc ccg ccg aaa cgc        192
Asp Val Leu Ile Asp Asn Gly Leu Asn Pro Pro Gly Pro Pro Lys Arg           
    50                  55                  60                            

att ctg att gtg ggc gcg ggc att gcg ggc ctg gtg gcg ggc gat ctg        240
Ile Leu Ile Val Gly Ala Gly Ile Ala Gly Leu Val Ala Gly Asp Leu           
65                  70                  75                  80            

ctg acc cgc gcg ggc cat gat gtg acc att ctg gaa gcg aac gcg aac        288
Leu Thr Arg Ala Gly His Asp Val Thr Ile Leu Glu Ala Asn Ala Asn           
                85                  90                  95                

cgc gtg ggc ggc cgc att aaa acc ttt cat gcg aaa aaa ggc gaa ccg        336
Arg Val Gly Gly Arg Ile Lys Thr Phe His Ala Lys Lys Gly Glu Pro           
            100                 105                 110                   

agc ccg ttt gcg gat ccg gcg cag tat gcg gaa gcg ggc gcg atg cgc        384
Ser Pro Phe Ala Asp Pro Ala Gln Tyr Ala Glu Ala Gly Ala Met Arg           
        115                 120                 125                       

ctg ccg agc ttt cat ccg ctg acc ctg gcg ctg att gat aaa ctg ggc        432
Leu Pro Ser Phe His Pro Leu Thr Leu Ala Leu Ile Asp Lys Leu Gly           
    130                 135                 140                           

ctg aaa cgc cgc ctg ttt ttt aac gtg gat att gat ccg cag acc ggc        480
Leu Lys Arg Arg Leu Phe Phe Asn Val Asp Ile Asp Pro Gln Thr Gly           
145                 150                 155                 160           

aac cag gat gcg ccg gtg ccg ccg gtg ttt tat aaa agc ttt aaa gat        528
Asn Gln Asp Ala Pro Val Pro Pro Val Phe Tyr Lys Ser Phe Lys Asp           
                165                 170                 175               

ggc aaa acc tgg acc aac ggc gcg ccg agc ccg gaa ttt aaa gaa ccg        576
Gly Lys Thr Trp Thr Asn Gly Ala Pro Ser Pro Glu Phe Lys Glu Pro           
            180                 185                 190                   

gat aaa cgc aac cat acc tgg att cgc acc aac cgc gaa cag gtg cgc        624
Asp Lys Arg Asn His Thr Trp Ile Arg Thr Asn Arg Glu Gln Val Arg           
        195                 200                 205                       

cgc gcg cag tat gcg acc gat ccg agc agc att aac gaa ggc ttt cat        672
Arg Ala Gln Tyr Ala Thr Asp Pro Ser Ser Ile Asn Glu Gly Phe His           
    210                 215                 220                           

ctg acc ggc tgc gaa acc cgc ctg acc gtg agc gat atg gtg aac cag        720
Leu Thr Gly Cys Glu Thr Arg Leu Thr Val Ser Asp Met Val Asn Gln           
225                 230                 235                 240           

gcg ctg gaa ccg gtg cgc gat tat tat agc gtg aaa cag gat gat ggc        768
Ala Leu Glu Pro Val Arg Asp Tyr Tyr Ser Val Lys Gln Asp Asp Gly           
                245                 250                 255               

acc cgc gtg aac aaa ccg ttt aaa gaa tgg ctg gcg ggc tgg gcg gat        816
Thr Arg Val Asn Lys Pro Phe Lys Glu Trp Leu Ala Gly Trp Ala Asp           
            260                 265                 270                   

gtg gtg cgc gat ttt gat ggc tat agc atg ggc cgc ttt ctg cgc gaa        864
Val Val Arg Asp Phe Asp Gly Tyr Ser Met Gly Arg Phe Leu Arg Glu           
        275                 280                 285                       

tat gcg gaa ttt agc gat gaa gcg gtg gaa gcg att ggc acc att gaa        912
Tyr Ala Glu Phe Ser Asp Glu Ala Val Glu Ala Ile Gly Thr Ile Glu           
    290                 295                 300                           

aac atg acc agc cgc ctg cat ctg gcg ttt ttt cat agc ttt ctg ggc        960
Asn Met Thr Ser Arg Leu His Leu Ala Phe Phe His Ser Phe Leu Gly           
305                 310                 315                 320           

cgc agc gat att gat ccg cgc gcg acc tat tgg gaa att gaa ggc ggc       1008
Arg Ser Asp Ile Asp Pro Arg Ala Thr Tyr Trp Glu Ile Glu Gly Gly           
                325                 330                 335               

agc cgc atg ctg ccg gaa acc ctg gcg aaa gat ctg cgc gat cag att       1056
Ser Arg Met Leu Pro Glu Thr Leu Ala Lys Asp Leu Arg Asp Gln Ile           
            340                 345                 350                   

gtg atg ggc cag cgc atg gtg cgc ctg gaa tat tat gat ccg ggc cgc       1104
Val Met Gly Gln Arg Met Val Arg Leu Glu Tyr Tyr Asp Pro Gly Arg           
        355                 360                 365                       

gat ggc cat cat ggc gaa ctg acc ggc ccg ggc ggc ccg gcg gtg gcg       1152
Asp Gly His His Gly Glu Leu Thr Gly Pro Gly Gly Pro Ala Val Ala           
    370                 375                 380                           

att cag acc gtg ccg gaa ggc gaa ccg tat gcg gcg acc cag acc tgg       1200
Ile Gln Thr Val Pro Glu Gly Glu Pro Tyr Ala Ala Thr Gln Thr Trp           
385                 390                 395                 400           

acc ggc gat ctg gcg att gtg acc att ccg ttt agc agc ctg cgc ttt       1248
Thr Gly Asp Leu Ala Ile Val Thr Ile Pro Phe Ser Ser Leu Arg Phe           
                405                 410                 415               

gtg aaa gtg acc ccg ccg ttt agc tat aaa aaa cgc cgc gcg gtg att       1296
Val Lys Val Thr Pro Pro Phe Ser Tyr Lys Lys Arg Arg Ala Val Ile           
            420                 425                 430                   

gaa acc cat tat gat cag gcg acc aaa gtg ctg ctg gaa ttt agc cgc       1344
Glu Thr His Tyr Asp Gln Ala Thr Lys Val Leu Leu Glu Phe Ser Arg           
        435                 440                 445                       

cgc tgg tgg gaa ttt acc gaa gcg gat tgg aaa cgc gaa ctg gat gcg       1392
Arg Trp Trp Glu Phe Thr Glu Ala Asp Trp Lys Arg Glu Leu Asp Ala           
    450                 455                 460                           

att gcg ccg ggc ctg tat gat tat tat cag cag tgg ggc gaa gat gat       1440
Ile Ala Pro Gly Leu Tyr Asp Tyr Tyr Gln Gln Trp Gly Glu Asp Asp           
465                 470                 475                 480           

gcg gaa gcg gcg ctg gcg ctg ccg cag agc gtg cgc aac ctg ccg acc       1488
Ala Glu Ala Ala Leu Ala Leu Pro Gln Ser Val Arg Asn Leu Pro Thr           
                485                 490                 495               

ggc ctg ctg ggc gcg cat ccg agc gtg gat gaa agc cgc att ggc gaa       1536
Gly Leu Leu Gly Ala His Pro Ser Val Asp Glu Ser Arg Ile Gly Glu           
            500                 505                 510                   

gaa cag gtg gaa tat tat cgc aac agc gaa ctg cgc ggc ggc gtg cgc       1584
Glu Gln Val Glu Tyr Tyr Arg Asn Ser Glu Leu Arg Gly Gly Val Arg           
        515                 520                 525                       

ccg gcg acc aac gcg tat ggc ggc ggc agc acc acc gat aac ccg aac       1632
Pro Ala Thr Asn Ala Tyr Gly Gly Gly Ser Thr Thr Asp Asn Pro Asn           
    530                 535                 540                           

cgc ttt atg tat tat ccg agc cat ccg gtg ccg ggc acc cag ggc ggc       1680
Arg Phe Met Tyr Tyr Pro Ser His Pro Val Pro Gly Thr Gln Gly Gly           
545                 550                 555                 560           

gtg gtg ctg gcg gcg tat agc tgg agc gat gat gcg gcg cgc tgg gat       1728
Val Val Leu Ala Ala Tyr Ser Trp Ser Asp Asp Ala Ala Arg Trp Asp           
                565                 570                 575               

agc ttt gat gat gcg gaa cgc tat ggc tat gcg ctg gaa aac ctg cag       1776
Ser Phe Asp Asp Ala Glu Arg Tyr Gly Tyr Ala Leu Glu Asn Leu Gln           
            580                 585                 590                   

agc gtg cat ggc cgc cgc att gaa gtg ttt tat acc ggc gcg ggc cag       1824
Ser Val His Gly Arg Arg Ile Glu Val Phe Tyr Thr Gly Ala Gly Gln           
        595                 600                 605                       

acc cag agc tgg ctg cgc gat ccg tat gcg tgc ggc gaa gcg gcg gtg       1872
Thr Gln Ser Trp Leu Arg Asp Pro Tyr Ala Cys Gly Glu Ala Ala Val           
    610                 615                 620                           

tat acc ccg cat cag atg acc gcg ttt cat ctg gat gtg gtg cgc ccg       1920
Tyr Thr Pro His Gln Met Thr Ala Phe His Leu Asp Val Val Arg Pro           
625                 630                 635                 640           

gaa ggc ccg gtg tat ttt gcg ggc gaa cat gtg agc ctg aaa cat gcg       1968
Glu Gly Pro Val Tyr Phe Ala Gly Glu His Val Ser Leu Lys His Ala           
                645                 650                 655               

tgg att gaa ggc gcg gtg gaa acc gcg gtg cgc gcg gcg att gcg gtg       2016
Trp Ile Glu Gly Ala Val Glu Thr Ala Val Arg Ala Ala Ile Ala Val           
            660                 665                 670                   

aac gaa gcg ccg gtg ggc gat acc ggc gtg acc gcg gcg gcg ggc cgc       2064
Asn Glu Ala Pro Val Gly Asp Thr Gly Val Thr Ala Ala Ala Gly Arg           
        675                 680                 685                       

cgc ggc gcg gcg gcg gcg acc gaa ccg atg cgc gaa gaa gcg ctg acc       2112
Arg Gly Ala Ala Ala Ala Thr Glu Pro Met Arg Glu Glu Ala Leu Thr           
    690                 695                 700                           

agc ctc gag ata tct                                                   2127
Ser Leu Glu Ile Ser                                                       
705                                                                       


<210> 6
<211> 2127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(2127)

<400> 6
cat atg aat tcg atg acc acc gat acc gcg cgc cgc cat acc att gaa         48
His Met Asn Ser Met Thr Thr Asp Thr Ala Arg Arg His Thr Ile Glu           
1               5                   10                  15                

ggc cgc gcg aac gaa atg acc tat gaa cag ctg gcg cgc gaa ctg ctg         96
Gly Arg Ala Asn Glu Met Thr Tyr Glu Gln Leu Ala Arg Glu Leu Leu           
            20                  25                  30                    

ctg gtg ggc ccg gcg ccg acc aac gaa gat ctg aaa ctg cgc tat ctg        144
Leu Val Gly Pro Ala Pro Thr Asn Glu Asp Leu Lys Leu Arg Tyr Leu           
        35                  40                  45                        

gat gtg ctg att gat aac ggc ctg aac ccg ccg ggc ccg ccg aaa cgc        192
Asp Val Leu Ile Asp Asn Gly Leu Asn Pro Pro Gly Pro Pro Lys Arg           
    50                  55                  60                            

att ctg att gtg ggc gcg ggc att gcg ggc ctg gtg gcg ggc gat ctg        240
Ile Leu Ile Val Gly Ala Gly Ile Ala Gly Leu Val Ala Gly Asp Leu           
65                  70                  75                  80            

ctg acc cgc gcg ggc cat gat gtg acc att ctg gaa gcg aac gcg aac        288
Leu Thr Arg Ala Gly His Asp Val Thr Ile Leu Glu Ala Asn Ala Asn           
                85                  90                  95                

cgc gtg ggc ggc cgc att aaa acc ttt cat gcg aaa aaa ggc gaa ccg        336
Arg Val Gly Gly Arg Ile Lys Thr Phe His Ala Lys Lys Gly Glu Pro           
            100                 105                 110                   

agc ccg ttt gcg gat ccg gcg cag tat gcg gaa gcg ggc gcg atg cgc        384
Ser Pro Phe Ala Asp Pro Ala Gln Tyr Ala Glu Ala Gly Ala Met Arg           
        115                 120                 125                       

ctg ccg agc ttt cat ccg ctg acc ctg gcg ctg att gat aaa ctg ggc        432
Leu Pro Ser Phe His Pro Leu Thr Leu Ala Leu Ile Asp Lys Leu Gly           
    130                 135                 140                           

ctg aaa cgc cgc ctg ttt ttt aac gtg gat att gat ccg cag acc ggc        480
Leu Lys Arg Arg Leu Phe Phe Asn Val Asp Ile Asp Pro Gln Thr Gly           
145                 150                 155                 160           

aac cag gat gcg ccg gtg ccg ccg gtg ttt tat aaa agc ttt aaa gat        528
Asn Gln Asp Ala Pro Val Pro Pro Val Phe Tyr Lys Ser Phe Lys Asp           
                165                 170                 175               

ggc aaa acc tgg acc aac ggc gcg ccg agc ccg gaa ttt aaa gaa ccg        576
Gly Lys Thr Trp Thr Asn Gly Ala Pro Ser Pro Glu Phe Lys Glu Pro           
            180                 185                 190                   

gat aaa cgc aac cat acc tgg att cgc acc aac cgc gaa cag gtg cgc        624
Asp Lys Arg Asn His Thr Trp Ile Arg Thr Asn Arg Glu Gln Val Arg           
        195                 200                 205                       

cgc gcg cag tat gcg acc gat ccg agc agc att aac gaa ggc ttt cat        672
Arg Ala Gln Tyr Ala Thr Asp Pro Ser Ser Ile Asn Glu Gly Phe His           
    210                 215                 220                           

ctg acc ggc tgc gaa acc cgc ctg acc gtg agc gat atg gtg aac cag        720
Leu Thr Gly Cys Glu Thr Arg Leu Thr Val Ser Asp Met Val Asn Gln           
225                 230                 235                 240           

gcg ctg gaa ccg gtg cgc gat tat tat agc gtg aaa cag gat gat ggc        768
Ala Leu Glu Pro Val Arg Asp Tyr Tyr Ser Val Lys Gln Asp Asp Gly           
                245                 250                 255               

acc cgc gtg aac aaa ccg ttt aaa gaa tgg ctg gcg ggc tgg gcg gat        816
Thr Arg Val Asn Lys Pro Phe Lys Glu Trp Leu Ala Gly Trp Ala Asp           
            260                 265                 270                   

gtg gtg cgc gat ttt gat ggc tat agc atg ggc cgc ttt ctg cgc gaa        864
Val Val Arg Asp Phe Asp Gly Tyr Ser Met Gly Arg Phe Leu Arg Glu           
        275                 280                 285                       

tat gcg gaa ttt agc gat gaa gcg gtg gaa gcg att ggc acc att gaa        912
Tyr Ala Glu Phe Ser Asp Glu Ala Val Glu Ala Ile Gly Thr Ile Glu           
    290                 295                 300                           

aac atg acc agc cgc ctg cat ctg gcg ttt ttt cat agc ttt ctg ggc        960
Asn Met Thr Ser Arg Leu His Leu Ala Phe Phe His Ser Phe Leu Gly           
305                 310                 315                 320           

cgc agc gat att gat ccg cgc gcg acc tat tgg gaa att gaa ggc ggc       1008
Arg Ser Asp Ile Asp Pro Arg Ala Thr Tyr Trp Glu Ile Glu Gly Gly           
                325                 330                 335               

agc cgc atg ctg ccg gaa acc ctg gcg aaa gat ctg cgc gat cag att       1056
Ser Arg Met Leu Pro Glu Thr Leu Ala Lys Asp Leu Arg Asp Gln Ile           
            340                 345                 350                   

gtg atg ggc cag cgc atg gtg cgc ctg gaa tat tat gat ccg ggc cgc       1104
Val Met Gly Gln Arg Met Val Arg Leu Glu Tyr Tyr Asp Pro Gly Arg           
        355                 360                 365                       

gat ggc cat cat ggc gaa ctg acc ggc ccg ggc ggc ccg gcg gtg gcg       1152
Asp Gly His His Gly Glu Leu Thr Gly Pro Gly Gly Pro Ala Val Ala           
    370                 375                 380                           

att cag acc gtg ccg gaa ggc gaa ccg tat att gaa ggc cgc acc tgg       1200
Ile Gln Thr Val Pro Glu Gly Glu Pro Tyr Ile Glu Gly Arg Thr Trp           
385                 390                 395                 400           

acc ggc gat ctg gcg att gtg acc att ccg ttt agc agc ctg cgc ttt       1248
Thr Gly Asp Leu Ala Ile Val Thr Ile Pro Phe Ser Ser Leu Arg Phe           
                405                 410                 415               

gtg aaa gtg acc ccg ccg ttt agc tat aaa aaa cgc cgc gcg gtg att       1296
Val Lys Val Thr Pro Pro Phe Ser Tyr Lys Lys Arg Arg Ala Val Ile           
            420                 425                 430                   

gaa acc cat tat gat cag gcg acc aaa gtg ctg ctg gaa ttt agc cgc       1344
Glu Thr His Tyr Asp Gln Ala Thr Lys Val Leu Leu Glu Phe Ser Arg           
        435                 440                 445                       

cgc tgg tgg gaa ttt acc gaa gcg gat tgg aaa cgc gaa ctg gat gcg       1392
Arg Trp Trp Glu Phe Thr Glu Ala Asp Trp Lys Arg Glu Leu Asp Ala           
    450                 455                 460                           

att gcg ccg ggc ctg tat gat tat tat cag cag tgg ggc gaa gat gat       1440
Ile Ala Pro Gly Leu Tyr Asp Tyr Tyr Gln Gln Trp Gly Glu Asp Asp           
465                 470                 475                 480           

gcg gaa gcg gcg ctg gcg ctg ccg cag agc gtg cgc aac ctg ccg acc       1488
Ala Glu Ala Ala Leu Ala Leu Pro Gln Ser Val Arg Asn Leu Pro Thr           
                485                 490                 495               

ggc ctg ctg ggc gcg cat ccg agc gtg gat gaa agc cgc att ggc gaa       1536
Gly Leu Leu Gly Ala His Pro Ser Val Asp Glu Ser Arg Ile Gly Glu           
            500                 505                 510                   

gaa cag gtg gaa tat tat cgc aac agc gaa att gaa ggc cgc gtg cgc       1584
Glu Gln Val Glu Tyr Tyr Arg Asn Ser Glu Ile Glu Gly Arg Val Arg           
        515                 520                 525                       

ccg gcg acc aac gcg tat ggc ggc ggc agc acc acc gat aac ccg aac       1632
Pro Ala Thr Asn Ala Tyr Gly Gly Gly Ser Thr Thr Asp Asn Pro Asn           
    530                 535                 540                           

cgc ttt atg tat tat ccg agc cat ccg gtg ccg ggc acc cag ggc ggc       1680
Arg Phe Met Tyr Tyr Pro Ser His Pro Val Pro Gly Thr Gln Gly Gly           
545                 550                 555                 560           

gtg gtg ctg gcg gcg tat agc tgg agc gat gat gcg gcg cgc tgg gat       1728
Val Val Leu Ala Ala Tyr Ser Trp Ser Asp Asp Ala Ala Arg Trp Asp           
                565                 570                 575               

agc ttt gat gat gcg gaa cgc tat ggc tat gcg ctg gaa aac ctg cag       1776
Ser Phe Asp Asp Ala Glu Arg Tyr Gly Tyr Ala Leu Glu Asn Leu Gln           
            580                 585                 590                   

agc gtg cat ggc cgc cgc att gaa gtg ttt tat acc ggc gcg ggc cag       1824
Ser Val His Gly Arg Arg Ile Glu Val Phe Tyr Thr Gly Ala Gly Gln           
        595                 600                 605                       

acc cag agc tgg ctg cgc gat ccg tat gcg tgc ggc gaa gcg gcg gtg       1872
Thr Gln Ser Trp Leu Arg Asp Pro Tyr Ala Cys Gly Glu Ala Ala Val           
    610                 615                 620                           

tat acc ccg cat cag atg acc gcg ttt cat ctg gat gtg gtg cgc ccg       1920
Tyr Thr Pro His Gln Met Thr Ala Phe His Leu Asp Val Val Arg Pro           
625                 630                 635                 640           

gaa ggc ccg gtg tat ttt gcg ggc gaa cat gtg agc ctg aaa cat gcg       1968
Glu Gly Pro Val Tyr Phe Ala Gly Glu His Val Ser Leu Lys His Ala           
                645                 650                 655               

tgg att gaa ggc gcg gtg gaa acc gcg gtg cgc gcg gcg att gcg gtg       2016
Trp Ile Glu Gly Ala Val Glu Thr Ala Val Arg Ala Ala Ile Ala Val           
            660                 665                 670                   

aac gaa gcg ccg gtg ggc gat acc ggc gtg acc gcg gcg gcg ggc cgc       2064
Asn Glu Ala Pro Val Gly Asp Thr Gly Val Thr Ala Ala Ala Gly Arg           
        675                 680                 685                       

cgc ggc gcg gcg gcg gcg acc gaa ccg atg cgc gaa gaa gcg ctg acc       2112
Arg Gly Ala Ala Ala Ala Thr Glu Pro Met Arg Glu Glu Ala Leu Thr           
    690                 695                 700                           

agc ctc gag ata tct                                                   2127
Ser Leu Glu Ile Ser                                                       
705                                                                       


<210> 7
<211> 713
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Ser Trp Tyr His Met Asn Asp Ile Arg Pro Gly His Arg Arg Glu Pro 
1               5                   10                  15      


Ser Gly Ala Glu Arg Ala Ala Ala Lys Thr Cys Gln Gln Leu Ala Arg 
            20                  25                  30          


Glu Leu Leu Leu Val Gly Pro Glu Pro Ala Asn Glu Asp Leu Lys Leu 
        35                  40                  45              


Arg Tyr Leu Asp Val Leu Ile Asp Asn Gly Leu Glu Pro Thr Ala Asp 
    50                  55                  60                  


Pro Lys Arg Ile Leu Ile Val Gly Ala Gly Ile Ala Gly Leu Val Ala 
65                  70                  75                  80  


Gly Asp Leu Leu Thr Arg Ala Gly His Glu Val Thr Ile Leu Glu Ala 
                85                  90                  95      


Asn Ala Asn Arg Val Gly Gly Arg Ile Lys Thr Phe His Ala Lys Lys 
            100                 105                 110         


Gly Glu Pro Pro Pro Phe Thr Asp Pro Ala Gln Tyr Ala Glu Ala Gly 
        115                 120                 125             


Ala Met Arg Leu Pro Ser Phe His Pro Leu Thr Leu Ala Leu Ile Asp 
    130                 135                 140                 


Lys Leu Gly Leu Lys Arg Arg Leu Phe Phe Asn Val Asp Ile Asp Pro 
145                 150                 155                 160 


Ala Thr Gly Asn Gln Asn Ala Pro Leu Pro Pro Val Val Tyr Lys Ser 
                165                 170                 175     


Phe Lys Asp Gly Lys Val Trp Thr Asn Gly Ala Pro Ser Pro Glu Phe 
            180                 185                 190         


Arg Ala Pro Asp Lys Arg Asn His Thr Trp Ile Arg Thr Asn Arg Thr 
        195                 200                 205             


Gln Val Arg Arg Ala Gln Tyr Ala Lys Asp Pro Ser Ala Ile Asn Glu 
    210                 215                 220                 


Gly Phe His Leu Thr Gly Ser Ala Ser Arg Leu Pro Val Ala Glu Met 
225                 230                 235                 240 


Val His Gln Ala Leu Glu Pro Val Arg Asp Tyr Tyr Ser Val Leu Gln 
                245                 250                 255     


Ser Asp Gly Thr Arg Val Asn Lys Pro Phe Gln Glu Trp Leu Asp Gly 
            260                 265                 270         


Trp Ala Glu Val Ile Arg Asp Phe Asp Gly Tyr Ser Met Gly Arg Phe 
        275                 280                 285             


Leu Arg Glu Tyr Ala Gly Leu Ser Asp Glu Ala Ile Glu Ala Ile Gly 
    290                 295                 300                 


Thr Ile Glu Asn Met Thr Ser Arg Leu His Leu Ala Phe Phe His Ser 
305                 310                 315                 320 


Phe Leu Gly Arg Ser Asp Ile Asp Pro Thr Ala Thr Tyr Trp Glu Ile 
                325                 330                 335     


Glu Gly Gly Ser Arg Arg Leu Pro Glu Ala Leu Ala Lys Asp Leu Arg 
            340                 345                 350         


Asp Gln Ile Val Met Gly Arg Arg Met Val Arg Leu Glu Tyr Tyr Asp 
        355                 360                 365             


Pro Gly Arg Asp Gly His Gln Gly Thr Leu Ala Gly Pro Gly Gly Pro 
    370                 375                 380                 


Ala Val Ala Ile Gln Thr Val Pro Glu Gly Asp Pro Tyr Gly Glu Pro 
385                 390                 395                 400 


Gln Thr Trp Thr Gly Asp Leu Ala Ile Val Thr Ile Pro Phe Ala Ser 
                405                 410                 415     


Leu Arg Phe Thr Thr Val Thr Pro Pro Phe Ser Tyr Lys Lys Arg Arg 
            420                 425                 430         


Ala Val Ile Glu Thr His Tyr Asp Gln Ala Thr Lys Val Leu Leu Glu 
        435                 440                 445             


Phe Ser Arg Arg Trp Trp Glu Phe Thr Glu Ala Asp Trp Lys Arg Glu 
    450                 455                 460                 


Leu Asp Thr Ile Ala Pro Gly Leu Tyr Glu Tyr Tyr Gln Gln Trp Gly 
465                 470                 475                 480 


Glu Asp Asp Ala Glu Ala Ala Val Ser Val Pro Gln His Leu Arg Asp 
                485                 490                 495     


Leu Pro Thr Gly Leu Leu Gly Ala His Pro Ser Val Asp Glu Lys Arg 
            500                 505                 510         


Ile Gly Gln Glu Gln Val Glu Tyr Tyr Arg Asn Ser Ser Leu Arg Gly 
        515                 520                 525             


Gly Val Arg Pro Ala Thr His Ala Val Gly Gly Gly Ser Thr Thr Asp 
    530                 535                 540                 


Asn Pro Asn Arg Phe Met Tyr Tyr Pro Ser His Pro Val Pro Gly Ser 
545                 550                 555                 560 


Ser Gly Gly Val Val Leu Ala Gly Tyr Ser Trp Ser Asp Asp Ala Ala 
                565                 570                 575     


Arg Trp Asp Ser Phe Asp Asp Ala Glu Arg Tyr Ser Tyr Ala Leu Leu 
            580                 585                 590         


Asn Leu Gln Ser Val His Gly Arg Arg Ile Glu Val Phe Tyr Thr Gly 
        595                 600                 605             


Ala Gly Gln Thr Gln Ser Trp Leu Arg Asp Pro Tyr Ala Cys Gly Glu 
    610                 615                 620                 


Ala Ala Val Tyr Thr Pro His Gln Met Thr Ser Phe His Leu Asp Ala 
625                 630                 635                 640 


Val Arg Ala Glu Gly Pro Val His Phe Ala Gly Glu His Val Ser Leu 
                645                 650                 655     


Lys His Ala Trp Ile Glu Gly Ala Val Glu Thr Ala Val Arg Ala Ala 
            660                 665                 670         


Leu Ala Val His Glu Ser Pro Ala Ala Cys Glu Ser Ala Ala Ala Ala 
        675                 680                 685             


Arg Thr Ala Glu Pro Gly Glu Ser Arg Ala Asp Ala Thr Pro Pro Ala 
    690                 695                 700                 


Pro Ser Gln Glu Asp Val Val Thr Ser 
705                 710             


<210> 8
<211> 733
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Arg Asp Pro Ser Trp Tyr His Met Asn Asp Ile Arg Pro Gly His Arg 
1               5                   10                  15      


Arg Glu Pro Ser Gly Ala Glu Arg Ala Asp Ile Glu Ala Arg Ala Ala 
            20                  25                  30          


Lys Thr Cys Gln Gln Leu Ala Arg Glu Leu Leu Leu Val Gly Pro Glu 
        35                  40                  45              


Pro Ala Asn Glu Asp Leu Lys Leu Arg Tyr Leu Asp Val Leu Ile Asp 
    50                  55                  60                  


Asn Gly Leu Glu Pro Thr Ala Asp Pro Lys Arg Ile Leu Ile Val Gly 
65                  70                  75                  80  


Ala Gly Ile Ala Gly Leu Val Ala Gly Asp Leu Leu Thr Arg Ala Gly 
                85                  90                  95      


His Glu Val Thr Ile Leu Glu Ala Asn Ala Asn Arg Val Gly Gly Arg 
            100                 105                 110         


Ile Lys Thr Phe His Ala Lys Lys Gly Glu Pro Pro Pro Phe Thr Asp 
        115                 120                 125             


Pro Ala Gln Tyr Ala Glu Ala Gly Ala Met Arg Leu Pro Ser Phe His 
    130                 135                 140                 


Pro Leu Thr Leu Ala Leu Ile Asp Lys Leu Gly Leu Lys Arg Arg Leu 
145                 150                 155                 160 


Phe Phe Asn Val Asp Ile Asp Pro Ala Thr Gly Asn Gln Asn Ala Pro 
                165                 170                 175     


Leu Pro Pro Val Val Tyr Lys Ser Phe Lys Asp Gly Lys Val Trp Thr 
            180                 185                 190         


Asn Gly Ala Pro Ser Pro Glu Phe Arg Ala Pro Asp Lys Arg Asn His 
        195                 200                 205             


Thr Trp Ile Arg Thr Asn Arg Thr Gln Val Arg Arg Ala Gln Tyr Ala 
    210                 215                 220                 


Lys Asp Pro Ser Ala Ile Asn Glu Gly Phe His Leu Thr Gly Ser Ala 
225                 230                 235                 240 


Ser Arg Leu Pro Val Ala Glu Met Val His Gln Ala Leu Glu Pro Val 
                245                 250                 255     


Arg Asp Tyr Tyr Ser Val Leu Gln Ser Asp Gly Thr Arg Val Asn Lys 
            260                 265                 270         


Pro Phe Gln Glu Trp Leu Asp Gly Trp Ala Glu Val Ile Arg Asp Phe 
        275                 280                 285             


Asp Gly Tyr Ser Met Gly Arg Phe Leu Arg Glu Tyr Ala Gly Leu Ser 
    290                 295                 300                 


Asp Glu Ala Ile Glu Ala Ile Gly Thr Ile Glu Asn Met Thr Ser Arg 
305                 310                 315                 320 


Leu His Leu Ala Phe Phe His Ser Phe Leu Gly Arg Ser Asp Ile Asp 
                325                 330                 335     


Pro Thr Ala Thr Tyr Trp Glu Ile Glu Gly Gly Ser Arg Arg Leu Pro 
            340                 345                 350         


Glu Ala Leu Ala Lys Asp Leu Arg Asp Gln Ile Val Met Gly Arg Arg 
        355                 360                 365             


Met Val Arg Leu Glu Tyr Tyr Asp Pro Gly Arg Asp Gly His Gln Gly 
    370                 375                 380                 


Thr Leu Ala Ile Asp Ala Arg Val Asp Gly Pro Gly Gly Pro Ala Val 
385                 390                 395                 400 


Ala Ile Gln Thr Val Pro Glu Gly Asp Pro Tyr Gly Glu Pro Gln Thr 
                405                 410                 415     


Trp Thr Gly Asp Leu Ala Ile Val Thr Ile Pro Phe Ala Ser Leu Arg 
            420                 425                 430         


Phe Thr Thr Val Thr Pro Pro Phe Ser Tyr Lys Lys Arg Arg Ala Val 
        435                 440                 445             


Ile Glu Thr His Tyr Asp Gln Ala Thr Lys Val Leu Leu Glu Phe Ser 
    450                 455                 460                 


Arg Arg Trp Trp Glu Phe Thr Glu Ala Asp Trp Lys Arg Glu Leu Asp 
465                 470                 475                 480 


Thr Ile Ala Pro Gly Leu Tyr Glu Tyr Tyr Gln Gln Trp Gly Glu Asp 
                485                 490                 495     


Asp Ala Glu Ala Ala Val Ser Val Pro Gln His Leu Arg Asp Leu Pro 
            500                 505                 510         


Thr Gly Leu Leu Gly Ala His Pro Ser Val Asp Glu Lys Arg Ile Gly 
        515                 520                 525             


Gln Glu Gln Val Glu Tyr Tyr Arg Asn Ser Ser Leu Arg Ile Glu Ala 
    530                 535                 540                 


Arg Glu Phe Gly Gly Val Arg Pro Ala Thr His Ala Val Gly Gly Gly 
545                 550                 555                 560 


Ser Thr Thr Asp Asn Pro Asn Arg Phe Met Tyr Tyr Pro Ser His Pro 
                565                 570                 575     


Val Pro Gly Ser Ser Gly Gly Val Val Leu Ala Gly Tyr Ser Trp Ser 
            580                 585                 590         


Asp Asp Ala Ala Arg Trp Asp Ser Phe Asp Asp Ala Glu Arg Tyr Ser 
        595                 600                 605             


Tyr Ala Leu Leu Asn Leu Gln Ser Val His Gly Arg Arg Ile Glu Val 
    610                 615                 620                 


Phe Tyr Thr Gly Ala Gly Gln Thr Gln Ser Trp Leu Arg Asp Pro Tyr 
625                 630                 635                 640 


Ala Cys Gly Glu Ala Ala Val Tyr Thr Pro His Gln Met Thr Ser Phe 
                645                 650                 655     


His Leu Asp Ala Val Arg Ala Glu Gly Pro Val His Phe Ala Gly Glu 
            660                 665                 670         


His Val Ser Leu Lys His Ala Trp Ile Glu Gly Ala Val Glu Thr Ala 
        675                 680                 685             


Val Arg Ala Ala Leu Ala Val His Glu Ser Pro Ala Ala Cys Glu Ser 
    690                 695                 700                 


Ala Ala Ala Ala Arg Thr Ala Glu Pro Gly Glu Ser Arg Ala Asp Ala 
705                 710                 715                 720 


Thr Pro Pro Ala Pro Ser Gln Glu Asp Val Val Thr Ser 
                725                 730             


<210> 9
<211> 709
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
His Met Asn Ser Met Thr Thr Asp Thr Ala Arg Arg His Thr Gly Ala 
1               5                   10                  15      


Glu Arg Ala Asn Glu Met Thr Tyr Glu Gln Leu Ala Arg Glu Leu Leu 
            20                  25                  30          


Leu Val Gly Pro Ala Pro Thr Asn Glu Asp Leu Lys Leu Arg Tyr Leu 
        35                  40                  45              


Asp Val Leu Ile Asp Asn Gly Leu Asn Pro Pro Gly Pro Pro Lys Arg 
    50                  55                  60                  


Ile Leu Ile Val Gly Ala Gly Ile Ala Gly Leu Val Ala Gly Asp Leu 
65                  70                  75                  80  


Leu Thr Arg Ala Gly His Asp Val Thr Ile Leu Glu Ala Asn Ala Asn 
                85                  90                  95      


Arg Val Gly Gly Arg Ile Lys Thr Phe His Ala Lys Lys Gly Glu Pro 
            100                 105                 110         


Ser Pro Phe Ala Asp Pro Ala Gln Tyr Ala Glu Ala Gly Ala Met Arg 
        115                 120                 125             


Leu Pro Ser Phe His Pro Leu Thr Leu Ala Leu Ile Asp Lys Leu Gly 
    130                 135                 140                 


Leu Lys Arg Arg Leu Phe Phe Asn Val Asp Ile Asp Pro Gln Thr Gly 
145                 150                 155                 160 


Asn Gln Asp Ala Pro Val Pro Pro Val Phe Tyr Lys Ser Phe Lys Asp 
                165                 170                 175     


Gly Lys Thr Trp Thr Asn Gly Ala Pro Ser Pro Glu Phe Lys Glu Pro 
            180                 185                 190         


Asp Lys Arg Asn His Thr Trp Ile Arg Thr Asn Arg Glu Gln Val Arg 
        195                 200                 205             


Arg Ala Gln Tyr Ala Thr Asp Pro Ser Ser Ile Asn Glu Gly Phe His 
    210                 215                 220                 


Leu Thr Gly Cys Glu Thr Arg Leu Thr Val Ser Asp Met Val Asn Gln 
225                 230                 235                 240 


Ala Leu Glu Pro Val Arg Asp Tyr Tyr Ser Val Lys Gln Asp Asp Gly 
                245                 250                 255     


Thr Arg Val Asn Lys Pro Phe Lys Glu Trp Leu Ala Gly Trp Ala Asp 
            260                 265                 270         


Val Val Arg Asp Phe Asp Gly Tyr Ser Met Gly Arg Phe Leu Arg Glu 
        275                 280                 285             


Tyr Ala Glu Phe Ser Asp Glu Ala Val Glu Ala Ile Gly Thr Ile Glu 
    290                 295                 300                 


Asn Met Thr Ser Arg Leu His Leu Ala Phe Phe His Ser Phe Leu Gly 
305                 310                 315                 320 


Arg Ser Asp Ile Asp Pro Arg Ala Thr Tyr Trp Glu Ile Glu Gly Gly 
                325                 330                 335     


Ser Arg Met Leu Pro Glu Thr Leu Ala Lys Asp Leu Arg Asp Gln Ile 
            340                 345                 350         


Val Met Gly Gln Arg Met Val Arg Leu Glu Tyr Tyr Asp Pro Gly Arg 
        355                 360                 365             


Asp Gly His His Gly Glu Leu Thr Gly Pro Gly Gly Pro Ala Val Ala 
    370                 375                 380                 


Ile Gln Thr Val Pro Glu Gly Glu Pro Tyr Ala Ala Thr Gln Thr Trp 
385                 390                 395                 400 


Thr Gly Asp Leu Ala Ile Val Thr Ile Pro Phe Ser Ser Leu Arg Phe 
                405                 410                 415     


Val Lys Val Thr Pro Pro Phe Ser Tyr Lys Lys Arg Arg Ala Val Ile 
            420                 425                 430         


Glu Thr His Tyr Asp Gln Ala Thr Lys Val Leu Leu Glu Phe Ser Arg 
        435                 440                 445             


Arg Trp Trp Glu Phe Thr Glu Ala Asp Trp Lys Arg Glu Leu Asp Ala 
    450                 455                 460                 


Ile Ala Pro Gly Leu Tyr Asp Tyr Tyr Gln Gln Trp Gly Glu Asp Asp 
465                 470                 475                 480 


Ala Glu Ala Ala Leu Ala Leu Pro Gln Ser Val Arg Asn Leu Pro Thr 
                485                 490                 495     


Gly Leu Leu Gly Ala His Pro Ser Val Asp Glu Ser Arg Ile Gly Glu 
            500                 505                 510         


Glu Gln Val Glu Tyr Tyr Arg Asn Ser Glu Leu Arg Gly Gly Val Arg 
        515                 520                 525             


Pro Ala Thr Asn Ala Tyr Gly Gly Gly Ser Thr Thr Asp Asn Pro Asn 
    530                 535                 540                 


Arg Phe Met Tyr Tyr Pro Ser His Pro Val Pro Gly Thr Gln Gly Gly 
545                 550                 555                 560 


Val Val Leu Ala Ala Tyr Ser Trp Ser Asp Asp Ala Ala Arg Trp Asp 
                565                 570                 575     


Ser Phe Asp Asp Ala Glu Arg Tyr Gly Tyr Ala Leu Glu Asn Leu Gln 
            580                 585                 590         


Ser Val His Gly Arg Arg Ile Glu Val Phe Tyr Thr Gly Ala Gly Gln 
        595                 600                 605             


Thr Gln Ser Trp Leu Arg Asp Pro Tyr Ala Cys Gly Glu Ala Ala Val 
    610                 615                 620                 


Tyr Thr Pro His Gln Met Thr Ala Phe His Leu Asp Val Val Arg Pro 
625                 630                 635                 640 


Glu Gly Pro Val Tyr Phe Ala Gly Glu His Val Ser Leu Lys His Ala 
                645                 650                 655     


Trp Ile Glu Gly Ala Val Glu Thr Ala Val Arg Ala Ala Ile Ala Val 
            660                 665                 670         


Asn Glu Ala Pro Val Gly Asp Thr Gly Val Thr Ala Ala Ala Gly Arg 
        675                 680                 685             


Arg Gly Ala Ala Ala Ala Thr Glu Pro Met Arg Glu Glu Ala Leu Thr 
    690                 695                 700                 


Ser Leu Glu Ile Ser 
705                 


<210> 10
<211> 709
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
His Met Asn Ser Met Thr Thr Asp Thr Ala Arg Arg His Thr Ile Glu 
1               5                   10                  15      


Gly Arg Ala Asn Glu Met Thr Tyr Glu Gln Leu Ala Arg Glu Leu Leu 
            20                  25                  30          


Leu Val Gly Pro Ala Pro Thr Asn Glu Asp Leu Lys Leu Arg Tyr Leu 
        35                  40                  45              


Asp Val Leu Ile Asp Asn Gly Leu Asn Pro Pro Gly Pro Pro Lys Arg 
    50                  55                  60                  


Ile Leu Ile Val Gly Ala Gly Ile Ala Gly Leu Val Ala Gly Asp Leu 
65                  70                  75                  80  


Leu Thr Arg Ala Gly His Asp Val Thr Ile Leu Glu Ala Asn Ala Asn 
                85                  90                  95      


Arg Val Gly Gly Arg Ile Lys Thr Phe His Ala Lys Lys Gly Glu Pro 
            100                 105                 110         


Ser Pro Phe Ala Asp Pro Ala Gln Tyr Ala Glu Ala Gly Ala Met Arg 
        115                 120                 125             


Leu Pro Ser Phe His Pro Leu Thr Leu Ala Leu Ile Asp Lys Leu Gly 
    130                 135                 140                 


Leu Lys Arg Arg Leu Phe Phe Asn Val Asp Ile Asp Pro Gln Thr Gly 
145                 150                 155                 160 


Asn Gln Asp Ala Pro Val Pro Pro Val Phe Tyr Lys Ser Phe Lys Asp 
                165                 170                 175     


Gly Lys Thr Trp Thr Asn Gly Ala Pro Ser Pro Glu Phe Lys Glu Pro 
            180                 185                 190         


Asp Lys Arg Asn His Thr Trp Ile Arg Thr Asn Arg Glu Gln Val Arg 
        195                 200                 205             


Arg Ala Gln Tyr Ala Thr Asp Pro Ser Ser Ile Asn Glu Gly Phe His 
    210                 215                 220                 


Leu Thr Gly Cys Glu Thr Arg Leu Thr Val Ser Asp Met Val Asn Gln 
225                 230                 235                 240 


Ala Leu Glu Pro Val Arg Asp Tyr Tyr Ser Val Lys Gln Asp Asp Gly 
                245                 250                 255     


Thr Arg Val Asn Lys Pro Phe Lys Glu Trp Leu Ala Gly Trp Ala Asp 
            260                 265                 270         


Val Val Arg Asp Phe Asp Gly Tyr Ser Met Gly Arg Phe Leu Arg Glu 
        275                 280                 285             


Tyr Ala Glu Phe Ser Asp Glu Ala Val Glu Ala Ile Gly Thr Ile Glu 
    290                 295                 300                 


Asn Met Thr Ser Arg Leu His Leu Ala Phe Phe His Ser Phe Leu Gly 
305                 310                 315                 320 


Arg Ser Asp Ile Asp Pro Arg Ala Thr Tyr Trp Glu Ile Glu Gly Gly 
                325                 330                 335     


Ser Arg Met Leu Pro Glu Thr Leu Ala Lys Asp Leu Arg Asp Gln Ile 
            340                 345                 350         


Val Met Gly Gln Arg Met Val Arg Leu Glu Tyr Tyr Asp Pro Gly Arg 
        355                 360                 365             


Asp Gly His His Gly Glu Leu Thr Gly Pro Gly Gly Pro Ala Val Ala 
    370                 375                 380                 


Ile Gln Thr Val Pro Glu Gly Glu Pro Tyr Ile Glu Gly Arg Thr Trp 
385                 390                 395                 400 


Thr Gly Asp Leu Ala Ile Val Thr Ile Pro Phe Ser Ser Leu Arg Phe 
                405                 410                 415     


Val Lys Val Thr Pro Pro Phe Ser Tyr Lys Lys Arg Arg Ala Val Ile 
            420                 425                 430         


Glu Thr His Tyr Asp Gln Ala Thr Lys Val Leu Leu Glu Phe Ser Arg 
        435                 440                 445             


Arg Trp Trp Glu Phe Thr Glu Ala Asp Trp Lys Arg Glu Leu Asp Ala 
    450                 455                 460                 


Ile Ala Pro Gly Leu Tyr Asp Tyr Tyr Gln Gln Trp Gly Glu Asp Asp 
465                 470                 475                 480 


Ala Glu Ala Ala Leu Ala Leu Pro Gln Ser Val Arg Asn Leu Pro Thr 
                485                 490                 495     


Gly Leu Leu Gly Ala His Pro Ser Val Asp Glu Ser Arg Ile Gly Glu 
            500                 505                 510         


Glu Gln Val Glu Tyr Tyr Arg Asn Ser Glu Ile Glu Gly Arg Val Arg 
        515                 520                 525             


Pro Ala Thr Asn Ala Tyr Gly Gly Gly Ser Thr Thr Asp Asn Pro Asn 
    530                 535                 540                 


Arg Phe Met Tyr Tyr Pro Ser His Pro Val Pro Gly Thr Gln Gly Gly 
545                 550                 555                 560 


Val Val Leu Ala Ala Tyr Ser Trp Ser Asp Asp Ala Ala Arg Trp Asp 
                565                 570                 575     


Ser Phe Asp Asp Ala Glu Arg Tyr Gly Tyr Ala Leu Glu Asn Leu Gln 
            580                 585                 590         


Ser Val His Gly Arg Arg Ile Glu Val Phe Tyr Thr Gly Ala Gly Gln 
        595                 600                 605             


Thr Gln Ser Trp Leu Arg Asp Pro Tyr Ala Cys Gly Glu Ala Ala Val 
    610                 615                 620                 


Tyr Thr Pro His Gln Met Thr Ala Phe His Leu Asp Val Val Arg Pro 
625                 630                 635                 640 


Glu Gly Pro Val Tyr Phe Ala Gly Glu His Val Ser Leu Lys His Ala 
                645                 650                 655     


Trp Ile Glu Gly Ala Val Glu Thr Ala Val Arg Ala Ala Ile Ala Val 
            660                 665                 670         


Asn Glu Ala Pro Val Gly Asp Thr Gly Val Thr Ala Ala Ala Gly Arg 
        675                 680                 685             


Arg Gly Ala Ala Ala Ala Thr Glu Pro Met Arg Glu Glu Ala Leu Thr 
    690                 695                 700                 


Ser Leu Glu Ile Ser 
705                 


<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 11
His His His His His His 
1               5       


<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Cys Thr Glu Ala Asp Trp Lys Arg Glu Leu Asp Thr Ile 
1               5                   10              


