                         SEQUENCE LISTING

<110>  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
       David, Weiner B.
       Yan, Jian
       Morrow, Matthew P.
 
<120>  INFLUENZA NUCLEIC ACID MOLECULES AND VACCINES MADE THEREFROM

<130>  UPVG0034 WO2

<150>  61787182
<151>  2013-03-15

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H1 DNA sequence

<400>  1
atgaaggcta tcctcgtcgt gctgctgtac accttcgcca ccgccaacgc cgataccctg       60

tgcatcggct accacgccaa caacagcacc gacaccgtgg ataccgtgct ggaaaagaac      120

gtgaccgtga cccacagcgt gaacctgctg gaagataagc acaacggcaa gctgtgcaag      180

ctgagaggcg tggcccctct gcacctgggc aagtgcaata tcgccggctg gattctgggc      240

aaccccgagt gcgagagcct gtctaccgct agctcctggt cctacatcgt ggagacaagc      300

agcagcgaca acggcacctg ttaccccggc gacttcatcg actacgagga actgcgggag      360

cagctgagca gcgtgtccag cttcgagcgg ttcgagatct tccccaagac cagctcctgg      420

cccaaccacg acagcaacaa gggcgtgacc gccgcctgtc ctcacgctgg cgccaagagc      480

ttctacaaga acctgatctg gctggtcaag aagggcaaca gctaccccaa gctgagcaag      540

agctacatca acgacaaggg caaagaggtc ctcgtcctct ggggcatcca ccaccctagc      600

accagcgccg accagcagag cctgtaccag aacgccgacg cctacgtgtt cgtgggctca      660

tctcggtaca gcaagaagtt caagcccgag atcgccatca gacccaaagt gcgggaccag      720

gaaggccgga tgaactacta ctggaccctg gtggagcccg gcgacaagat caccttcgag      780

gccaccggca atctggtggt gcccagatac gccttcgcca tggaaagaaa cgccggcagc      840

ggcatcatca tcagcgacac ccccgtgcac gactgcaaca ccacctgtca gacccccaag      900

ggcgccatca acaccagcct gcccttccag aacatccacc ccatcaccat cggcaagtgc      960

cctaagtacg tgaagtccac taagctcaga ctggccaccg gcctgagaaa cgtgcccagc     1020

atccagagca gaggcctgtt tggcgccatt gccggcttta tcgagggcgg ctggaccgga     1080

atggtggacg ggtggtacgg ctaccaccac cagaatgagc agggcagcgg ctacgccgcc     1140

gacctgaagt ccacacagaa cgccatcgac gagatcacca acaaagtgaa cagcgtgatc     1200

gagaagatga acacccagtt caccgccgtg ggcaaagagt tcaaccacct ggaaaagcgg     1260

atcgagaacc tgaacaagaa ggtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctgg tgctgctgga aaacgagcgg accctggact accacgactc caacgtgaag     1380

aatctgtacg agaaagtgcg gagccagctg aagaacaacg ccaaagagat cggcaacggc     1440

tgcttcgagt tctaccacaa gtgcgacaac acctgtatgg aaagcgtgaa gaacggcacc     1500

tacgactacc ccaagtacag cgaggaagcc aagctgaacc gggaagagat cgacggcgtg     1560

aagctggaaa gcacccggat ctaccagatc ctggccatct actctactgt ggccagctca     1620

ctggtgctgg tggtgtccct gggcgccatc tccttttgga tgtgctccaa cggcagcctg     1680

cagtgccgga tctgc                                                      1695


<210>  2
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza Protein H1 Sequence

<400>  2

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  3
<211>  1818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgE-H1-HAT Antigen DNA Sequence

<400>  3
ttaattaagg atccgccacc atggactgga cctggattct gttcctggtg gctgctgcca       60

ctagagtgca cagcatgaag gctatcctcg tcgtgctgct gtacaccttc gccaccgcca      120

acgccgatac cctgtgcatc ggctaccacg ccaacaacag caccgacacc gtggataccg      180

tgctggaaaa gaacgtgacc gtgacccaca gcgtgaacct gctggaagat aagcacaacg      240

gcaagctgtg caagctgaga ggcgtggccc ctctgcacct gggcaagtgc aatatcgccg      300

gctggattct gggcaacccc gagtgcgaga gcctgtctac cgctagctcc tggtcctaca      360

tcgtggagac aagcagcagc gacaacggca cctgttaccc cggcgacttc atcgactacg      420

aggaactgcg ggagcagctg agcagcgtgt ccagcttcga gcggttcgag atcttcccca      480

agaccagctc ctggcccaac cacgacagca acaagggcgt gaccgccgcc tgtcctcacg      540

ctggcgccaa gagcttctac aagaacctga tctggctggt caagaagggc aacagctacc      600

ccaagctgag caagagctac atcaacgaca agggcaaaga ggtcctcgtc ctctggggca      660

tccaccaccc tagcaccagc gccgaccagc agagcctgta ccagaacgcc gacgcctacg      720

tgttcgtggg ctcatctcgg tacagcaaga agttcaagcc cgagatcgcc atcagaccca      780

aagtgcggga ccaggaaggc cggatgaact actactggac cctggtggag cccggcgaca      840

agatcacctt cgaggccacc ggcaatctgg tggtgcccag atacgccttc gccatggaaa      900

gaaacgccgg cagcggcatc atcatcagcg acacccccgt gcacgactgc aacaccacct      960

gtcagacccc caagggcgcc atcaacacca gcctgccctt ccagaacatc caccccatca     1020

ccatcggcaa gtgccctaag tacgtgaagt ccactaagct cagactggcc accggcctga     1080

gaaacgtgcc cagcatccag agcagaggcc tgtttggcgc cattgccggc tttatcgagg     1140

gcggctggac cggaatggtg gacgggtggt acggctacca ccaccagaat gagcagggca     1200

gcggctacgc cgccgacctg aagtccacac agaacgccat cgacgagatc accaacaaag     1260

tgaacagcgt gatcgagaag atgaacaccc agttcaccgc cgtgggcaaa gagttcaacc     1320

acctggaaaa gcggatcgag aacctgaaca agaaggtgga cgacggcttc ctggacatct     1380

ggacctacaa cgccgagctg ctggtgctgc tggaaaacga gcggaccctg gactaccacg     1440

actccaacgt gaagaatctg tacgagaaag tgcggagcca gctgaagaac aacgccaaag     1500

agatcggcaa cggctgcttc gagttctacc acaagtgcga caacacctgt atggaaagcg     1560

tgaagaacgg cacctacgac taccccaagt acagcgagga agccaagctg aaccgggaag     1620

agatcgacgg cgtgaagctg gaaagcaccc ggatctacca gatcctggcc atctactcta     1680

ctgtggccag ctcactggtg ctggtggtgt ccctgggcgc catctccttt tggatgtgct     1740

ccaacggcag cctgcagtgc cggatctgca tctaccccta cgacgtgccc gactacgcct     1800

gatgactcga ggcgcgcc                                                   1818


<210>  4
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE-H1-HATanitgen amino acid seqeunce

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr 
            20                  25                  30          


Ala Asn Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr 
        35                  40                  45              


Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
    50                  55                  60                  


Val Asn Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg 
65                  70                  75                  80  


Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile 
                85                  90                  95      


Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser 
            100                 105                 110         


Tyr Ile Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly 
        115                 120                 125             


Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser 
    130                 135                 140                 


Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn 
145                 150                 155                 160 


His Asp Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala 
                165                 170                 175     


Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser 
            180                 185                 190         


Tyr Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val 
        195                 200                 205             


Leu Val Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln 
    210                 215                 220                 


Ser Leu Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg 
225                 230                 235                 240 


Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg 
                245                 250                 255     


Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly 
            260                 265                 270         


Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr 
        275                 280                 285             


Ala Phe Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp 
    290                 295                 300                 


Thr Pro Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala 
305                 310                 315                 320 


Ile Asn Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly 
                325                 330                 335     


Lys Cys Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly 
            340                 345                 350         


Leu Arg Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr 
    370                 375                 380                 


Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser 
                405                 410                 415     


Val Ile Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe 
            420                 425                 430         


Asn His Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp 
        435                 440                 445             


Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu 
    450                 455                 460                 


Glu Asn Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu 
465                 470                 475                 480 


Tyr Glu Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu 
            500                 505                 510         


Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala 
        515                 520                 525             


Lys Leu Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg 
    530                 535                 540                 


Ile Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val 
545                 550                 555                 560 


Leu Val Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly 
                565                 570                 575     


Ser Leu Gln Cys Arg Ile Cys Ile Tyr Pro Tyr Asp Val Pro Asp Tyr 
            580                 585                 590         


Ala 
    


<210>  5
<211>  4739
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX2009 HS09 DNA sequence

<400>  5
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggactgg acctggattc tgttcctggt ggctgctgcc      780

actagagtgc acagcatgaa ggctatcctc gtcgtgctgc tgtacacctt cgccaccgcc      840

aacgccgata ccctgtgcat cggctaccac gccaacaaca gcaccgacac cgtggatacc      900

gtgctggaaa agaacgtgac cgtgacccac agcgtgaacc tgctggaaga taagcacaac      960

ggcaagctgt gcaagctgag aggcgtggcc cctctgcacc tgggcaagtg caatatcgcc     1020

ggctggattc tgggcaaccc cgagtgcgag agcctgtcta ccgctagctc ctggtcctac     1080

atcgtggaga caagcagcag cgacaacggc acctgttacc ccggcgactt catcgactac     1140

gaggaactgc gggagcagct gagcagcgtg tccagcttcg agcggttcga gatcttcccc     1200

aagaccagct cctggcccaa ccacgacagc aacaagggcg tgaccgccgc ctgtcctcac     1260

gctggcgcca agagcttcta caagaacctg atctggctgg tcaagaaggg caacagctac     1320

cccaagctga gcaagagcta catcaacgac aagggcaaag aggtcctcgt cctctggggc     1380

atccaccacc ctagcaccag cgccgaccag cagagcctgt accagaacgc cgacgcctac     1440

gtgttcgtgg gctcatctcg gtacagcaag aagttcaagc ccgagatcgc catcagaccc     1500

aaagtgcggg accaggaagg ccggatgaac tactactgga ccctggtgga gcccggcgac     1560

aagatcacct tcgaggccac cggcaatctg gtggtgccca gatacgcctt cgccatggaa     1620

agaaacgccg gcagcggcat catcatcagc gacacccccg tgcacgactg caacaccacc     1680

tgtcagaccc ccaagggcgc catcaacacc agcctgccct tccagaacat ccaccccatc     1740

accatcggca agtgccctaa gtacgtgaag tccactaagc tcagactggc caccggcctg     1800

agaaacgtgc ccagcatcca gagcagaggc ctgtttggcg ccattgccgg ctttatcgag     1860

ggcggctgga ccggaatggt ggacgggtgg tacggctacc accaccagaa tgagcagggc     1920

agcggctacg ccgccgacct gaagtccaca cagaacgcca tcgacgagat caccaacaaa     1980

gtgaacagcg tgatcgagaa gatgaacacc cagttcaccg ccgtgggcaa agagttcaac     2040

cacctggaaa agcggatcga gaacctgaac aagaaggtgg acgacggctt cctggacatc     2100

tggacctaca acgccgagct gctggtgctg ctggaaaacg agcggaccct ggactaccac     2160

gactccaacg tgaagaatct gtacgagaaa gtgcggagcc agctgaagaa caacgccaaa     2220

gagatcggca acggctgctt cgagttctac cacaagtgcg acaacacctg tatggaaagc     2280

gtgaagaacg gcacctacga ctaccccaag tacagcgagg aagccaagct gaaccgggaa     2340

gagatcgacg gcgtgaagct ggaaagcacc cggatctacc agatcctggc catctactct     2400

actgtggcca gctcactggt gctggtggtg tccctgggcg ccatctcctt ttggatgtgc     2460

tccaacggca gcctgcagtg ccggatctgc atctacccct acgacgtgcc cgactacgcc     2520

tgatgactcg agtctagagg gcccgtttaa acccgctgat cagcctcgac tgtgccttct     2580

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     2640

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     2700

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     2760

agcaggcatg ctggggatgc ggtgggctct atggcttcta ctgggcggtt ttatggacag     2820

caagcgaacc ggaattgcca gctggggcgc cctctggtaa ggttgggaag ccctgcaaag     2880

taaactggat ggctttcttg ccgccaagga tctgatggcg caggggatca agctctgatc     2940

aagagacagg atgaggatcg tttcgcatga ttgaacaaga tggattgcac gcaggttctc     3000

cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca atcggctgct     3060

ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg     3120

acctgtccgg tgccctgaat gaactgcaag acgaggcagc gcggctatcg tggctggcca     3180

cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga agggactggc     3240

tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct cctgccgaga     3300

aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg gctacctgcc     3360

cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg gaagccggtc     3420

ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc gaactgttcg     3480

ccaggctcaa ggcgagcatg cccgacggcg aggatctcgt cgtgacccat ggcgatgcct     3540

gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac tgtggccggc     3600

tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt gctgaagagc     3660

ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct cccgattcgc     3720

agcgcatcgc cttctatcgc cttcttgacg agttcttctg aattattaac gcttacaatt     3780

tcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atcaggtggc     3840

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     3900

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatagca cgtgctaaaa     3960

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     4020

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     4080

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     4140

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     4200

ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac     4260

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     4320

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     4380

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     4440

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     4500

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     4560

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     4620

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     4680

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttctt      4739


<210>  6
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H2 antigen DNA sequence

<400>  6
ggtaccaagc ttgccaccat ggccatcatc tacctgatcc tgctgttcac cgccgtgcgg       60

ggcgaccaga tctgcatcgg ctaccacgcc aacaacagca ccgagaaggt ggacaccatc      120

ctggaacgga acgtgaccgt gacccacgcc aaggacatcc tggaaaagac ccacaacggc      180

aagctgtgca agctgaacgg catccccccc ctggaactgg gcgactgcag cattgccggc      240

tggctgctgg gcaaccccga gtgcgaccgg ctgctgtccg tgcccgagtg gagctacatc      300

atggaaaaag agaacccccg ggacggcctg tgctaccccg gcagcttcaa cgactacgag      360

gaactgaagc acctgctgtc cagcgtgaag cacttcgaga aggtgaaaat cctgcccaag      420

gaccggtgga cccagcacac caccaccggc ggcagcagag cctgtgccgt gagcggcaac      480

cccagcttct tccggaacat ggtgtggctg accaagaagg gcagcaacta ccccgtggcc      540

aagggcagct acaacaacac ctccggagaa cagatgctga tcatctgggg cgtgcaccac      600

cccaacgacg agacagagca gcggaccctg taccagaacg tgggcaccta cgtgagcgtg      660

ggcaccagca ccctgaacaa gcggagcacc cccgagatcg ccacccggcc caaggtgaac      720

ggcctgggca gccggatgga attcagctgg accctgctgg acatgtggga caccatcaac      780

ttcgagagca ccggcaacct gatcgccccc gagtacggct tcaagatcag caagcggggc      840

agcagcggca tcatgaaaac cgagggcacc ctggaaaact gcgagacaaa gtgccagacc      900

cccctgggcg ccatcaacac caccctgccc ttccacaacg tgcaccccct gaccatcggc      960

gagtgcccca agtacgtgaa gagcgagaag ctggtgctgg ccaccggcct gcggaacgtg     1020

ccccagatcg agagcagggg cctgttcggc gccattgccg gattcatcga gggcggctgg     1080

cagggcatgg tggacgggtg gtacggctac caccacagca acgaccaggg cagcggctac     1140

gccgccgaca aagagagcac ccagaaggcc ttcgacggca tcaccaacaa ggtgaacagc     1200

gtgatcgaga agatgaacac ccagttcgag gccgtgggca aagagttcag caacctggaa     1260

cggcggctgg aaaacctgaa caagaaaatg gaagatggct tcctggacgt gtggacctac     1320

aacgccgagc tgctggtgct gatggaaaac gagaggaccc tggacttcca cgacagcaac     1380

gtgaagaacc tgtacgacaa agtgcggatg cagctgcggg acaacgtgaa agagctgggc     1440

aacggctgct tcgagttcta ccacaagtgc gacgacgagt gcatgaactc cgtgaagaac     1500

ggcacctacg actaccctaa gtacgaggaa gagtccaagc tgaaccggaa cgagatcaag     1560

ggcgtgaagc tgtccagcat gggcgtgtac cagatcctgg ccatctacgc caccgtggcc     1620

ggcagcctga gcctggctat tatgatggct ggcatcagct tttggatgtg cagcaacggc     1680

agcctgcagt gccggatctg catctgatga ctcgagctc                            1719


<210>  7
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H2 amino acid sequence

<400>  7

Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Asp 
1               5                   10                  15      


Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Lys Val Asp 
            20                  25                  30          


Thr Ile Leu Glu Arg Asn Val Thr Val Thr His Ala Lys Asp Ile Leu 
        35                  40                  45              


Glu Lys Thr His Asn Gly Lys Leu Cys Lys Leu Asn Gly Ile Pro Pro 
    50                  55                  60                  


Leu Glu Leu Gly Asp Cys Ser Ile Ala Gly Trp Leu Leu Gly Asn Pro 
65                  70                  75                  80  


Glu Cys Asp Arg Leu Leu Ser Val Pro Glu Trp Ser Tyr Ile Met Glu 
                85                  90                  95      


Lys Glu Asn Pro Arg Asp Gly Leu Cys Tyr Pro Gly Ser Phe Asn Asp 
            100                 105                 110         


Tyr Glu Glu Leu Lys His Leu Leu Ser Ser Val Lys His Phe Glu Lys 
        115                 120                 125             


Val Lys Ile Leu Pro Lys Asp Arg Trp Thr Gln His Thr Thr Thr Gly 
    130                 135                 140                 


Gly Ser Arg Ala Cys Ala Val Ser Gly Asn Pro Ser Phe Phe Arg Asn 
145                 150                 155                 160 


Met Val Trp Leu Thr Lys Lys Gly Ser Asn Tyr Pro Val Ala Lys Gly 
                165                 170                 175     


Ser Tyr Asn Asn Thr Ser Gly Glu Gln Met Leu Ile Ile Trp Gly Val 
            180                 185                 190         


His His Pro Asn Asp Glu Thr Glu Gln Arg Thr Leu Tyr Gln Asn Val 
        195                 200                 205             


Gly Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Lys Arg Ser Thr 
    210                 215                 220                 


Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Leu Gly Ser Arg Met 
225                 230                 235                 240 


Glu Phe Ser Trp Thr Leu Leu Asp Met Trp Asp Thr Ile Asn Phe Glu 
                245                 250                 255     


Ser Thr Gly Asn Leu Ile Ala Pro Glu Tyr Gly Phe Lys Ile Ser Lys 
            260                 265                 270         


Arg Gly Ser Ser Gly Ile Met Lys Thr Glu Gly Thr Leu Glu Asn Cys 
        275                 280                 285             


Glu Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Thr Thr Leu Pro 
    290                 295                 300                 


Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val 
305                 310                 315                 320 


Lys Ser Glu Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Val Pro Gln 
                325                 330                 335     


Ile Glu Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
            340                 345                 350         


Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn 
        355                 360                 365             


Asp Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala 
    370                 375                 380                 


Phe Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn 
385                 390                 395                 400 


Thr Gln Phe Glu Ala Val Gly Lys Glu Phe Ser Asn Leu Glu Arg Arg 
                405                 410                 415     


Leu Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp 
            420                 425                 430         


Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu 
        435                 440                 445             


Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Met 
    450                 455                 460                 


Gln Leu Arg Asp Asn Val Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe 
465                 470                 475                 480 


Tyr His Lys Cys Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr 
                485                 490                 495     


Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu 
            500                 505                 510         


Ile Lys Gly Val Lys Leu Ser Ser Met Gly Val Tyr Gln Ile Leu Ala 
        515                 520                 525             


Ile Tyr Ala Thr Val Ala Gly Ser Leu Ser Leu Ala Ile Met Met Ala 
    530                 535                 540                 


Gly Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
545                 550                 555                 560 


Cys Ile 
        


<210>  8
<211>  4628
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX2006 H2HA DNA sequence

<400>  8
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttgcc      720

accatggcca tcatctacct gatcctgctg ttcaccgccg tgcggggcga ccagatctgc      780

atcggctacc acgccaacaa cagcaccgag aaggtggaca ccatcctgga acggaacgtg      840

accgtgaccc acgccaagga catcctggaa aagacccaca acggcaagct gtgcaagctg      900

aacggcatcc cccccctgga actgggcgac tgcagcattg ccggctggct gctgggcaac      960

cccgagtgcg accggctgct gtccgtgccc gagtggagct acatcatgga aaaagagaac     1020

ccccgggacg gcctgtgcta ccccggcagc ttcaacgact acgaggaact gaagcacctg     1080

ctgtccagcg tgaagcactt cgagaaggtg aaaatcctgc ccaaggaccg gtggacccag     1140

cacaccacca ccggcggcag cagagcctgt gccgtgagcg gcaaccccag cttcttccgg     1200

aacatggtgt ggctgaccaa gaagggcagc aactaccccg tggccaaggg cagctacaac     1260

aacacctccg gagaacagat gctgatcatc tggggcgtgc accaccccaa cgacgagaca     1320

gagcagcgga ccctgtacca gaacgtgggc acctacgtga gcgtgggcac cagcaccctg     1380

aacaagcgga gcacccccga gatcgccacc cggcccaagg tgaacggcct gggcagccgg     1440

atggaattca gctggaccct gctggacatg tgggacacca tcaacttcga gagcaccggc     1500

aacctgatcg cccccgagta cggcttcaag atcagcaagc ggggcagcag cggcatcatg     1560

aaaaccgagg gcaccctgga aaactgcgag acaaagtgcc agacccccct gggcgccatc     1620

aacaccaccc tgcccttcca caacgtgcac cccctgacca tcggcgagtg ccccaagtac     1680

gtgaagagcg agaagctggt gctggccacc ggcctgcgga acgtgcccca gatcgagagc     1740

aggggcctgt tcggcgccat tgccggattc atcgagggcg gctggcaggg catggtggac     1800

gggtggtacg gctaccacca cagcaacgac cagggcagcg gctacgccgc cgacaaagag     1860

agcacccaga aggccttcga cggcatcacc aacaaggtga acagcgtgat cgagaagatg     1920

aacacccagt tcgaggccgt gggcaaagag ttcagcaacc tggaacggcg gctggaaaac     1980

ctgaacaaga aaatggaaga tggcttcctg gacgtgtgga cctacaacgc cgagctgctg     2040

gtgctgatgg aaaacgagag gaccctggac ttccacgaca gcaacgtgaa gaacctgtac     2100

gacaaagtgc ggatgcagct gcgggacaac gtgaaagagc tgggcaacgg ctgcttcgag     2160

ttctaccaca agtgcgacga cgagtgcatg aactccgtga agaacggcac ctacgactac     2220

cctaagtacg aggaagagtc caagctgaac cggaacgaga tcaagggcgt gaagctgtcc     2280

agcatgggcg tgtaccagat cctggccatc tacgccaccg tggccggcag cctgagcctg     2340

gctattatga tggctggcat cagcttttgg atgtgcagca acggcagcct gcagtgccgg     2400

atctgcatct gatgactcga gtctagaggg cccgtttaaa cccgctgatc agcctcgact     2460

gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg     2520

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg     2580

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg     2640

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctac tgggcggttt     2700

tatggacagc aagcgaaccg gaattgccag ctggggcgcc ctctggtaag gttgggaagc     2760

cctgcaaagt aaactggatg gctttcttgc cgccaaggat ctgatggcgc aggggatcaa     2820

gctctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg     2880

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa     2940

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg     3000

tcaagaccga cctgtccggt gccctgaatg aactgcaaga cgaggcagcg cggctatcgt     3060

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa     3120

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc     3180

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg     3240

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg     3300

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg     3360

aactgttcgc caggctcaag gcgagcatgc ccgacggcga ggatctcgtc gtgacccatg     3420

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact     3480

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg     3540

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc     3600

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga attattaacg     3660

cttacaattt cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca     3720

tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata     3780

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatagcac     3840

gtgctaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     3900

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     3960

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     4020

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     4080

aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt gtagccgtag     4140

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     4200

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     4260

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     4320

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     4380

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     4440

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     4500

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     4560

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     4620

atgttctt                                                              4628


<210>  9
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza U2 DNA sequence

<400>  9
aaggccaagc tgctggtgct gctgtgcacc ttcgccgcca ccaacgccga caccatctgc       60

atcggctacc acgccaacaa cagcaccgac accgtggata ccgtgctgga aaagaacgtg      120

accgtgaccc acagcgtgaa cctgctggaa gataagcaca acggcaagct gtgcaagctg      180

aagggaatcg cccccctgca gctgggcaag tgcaatatcg ccggctggat tctgggcaac      240

cccgagtgcg agagcctgag cagcaagagc agctggtcct acatcgtgga aacccccaac      300

agcgagaacg gcacctgtta ccccggcgac ttcgccgact acgaggaact gcgcgagcag      360

ctgagcagcg tgtccagctt cgagagattc gagatcttcc ccaagaccag cagctggccc      420

aaccacgacg tgaccaaggg cgtgaccgct agctgtagcc acgcaggcgc cagcagcttc      480

tacaagaacc tgctgtggct gaccaagaag aacggcagct accccaagct gagcaagagc      540

tacatcaaca acaaagaaaa agaggtgctg gtcctctggg gcgtccacca ccccagcaca      600

atcgccgacc agcagagcct gtaccagaac gagaacgcct acgtgtccgt gggcagcagc      660

cactacagcc ggaagttcac ccccgagatc gccaagcggc ccaaagtgcg ggaccaggaa      720

ggccggatca actactactg gaccctgctg gaacccggcg acaccatcat cttcgaggcc      780

aacggcaacc tgatcgcccc cagatacgcc ttcgccctga gcagaggctt cggcagcggc      840

atcatcatca gcaacgcccc catgcacgac tgcgacacca agtgccagac ccctcagggc      900

gccatcaaca gcagcctgcc cttccagaac atccaccccg tgaccatcgg cgagtgcccc      960

aaatacgtgc ggagcaccaa gctgcggatg gccaccggcc tgcggaacat ccccagcatc     1020

cagagcagag gcctgttcgg cgccattgcc ggcttcatcg agggcggctg gaccggaatg     1080

gtggacgggt ggtacggcta ccaccaccag aatgagcagg gcagcggcta cgccgccgac     1140

cagaagtcca cccagaacgc catcgacggc atcaccaaca aagtgaacag cgtgatcgag     1200

aagatgaaca cccagttcac cgccgtgggc aaagagttca acaagctgga aaagcggatg     1260

gaaaacctga acaagaaggt ggacgacggc ttcctggaca tctggaccta caacgccgaa     1320

ctgctcgtgc tgctggaaaa cgagcggacc ctggacttcc acgacagcaa cgtgaagaac     1380

ctgtacgaga aagtgaagtc ccagctgaag aacaacgcca aagagatcgg caacggctgc     1440

ttcgagttct accacaagtg caacaacgag tgcatggaaa gcgtgaagaa cggaacctac     1500

gactacccca agtacagcga ggaaagcaag ctgaaccggg aagagatcga cggcgtgaag     1560

ctggaatcca tgggcgtgta ccagatcctg gccatctaca gcaccgtggc tagcagcctg     1620

gtgctgctgg tgtccctggg cgccatctcc ttttggatgt gctccaacgg cagcctgcag     1680

tgccggatct gcatc                                                      1695


<210>  10
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza U2 amino acid sequence

<400>  10

Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Ala Ala Thr Asn Ala 
1               5                   10                  15      


Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val 
            20                  25                  30          


Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu 
        35                  40                  45              


Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile Ala 
    50                  55                  60                  


Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly Asn 
65                  70                  75                  80  


Pro Glu Cys Glu Ser Leu Ser Ser Lys Ser Ser Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe Ala 
            100                 105                 110         


Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu 
        115                 120                 125             


Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp Val 
    130                 135                 140                 


Thr Lys Gly Val Thr Ala Ser Cys Ser His Ala Gly Ala Ser Ser Phe 
145                 150                 155                 160 


Tyr Lys Asn Leu Leu Trp Leu Thr Lys Lys Asn Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ile Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Ser Thr Ile Ala Asp Gln Gln Ser Leu Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Gly Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Ile Ser Asn Ala Pro Met 
        275                 280                 285             


His Asp Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  11
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgE-U2-HATAntigen DNA Sequence

<400>  11
ggtaccggat ccgccaccat ggactggacc tggattctgt tcctggtcgc cgctgctacc       60

cgggtgcact ctaaggccaa gctgctggtg ctgctgtgca ccttcgccgc caccaacgcc      120

gacaccatct gcatcggcta ccacgccaac aacagcaccg acaccgtgga taccgtgctg      180

gaaaagaacg tgaccgtgac ccacagcgtg aacctgctgg aagataagca caacggcaag      240

ctgtgcaagc tgaagggaat cgcccccctg cagctgggca agtgcaatat cgccggctgg      300

attctgggca accccgagtg cgagagcctg agcagcaaga gcagctggtc ctacatcgtg      360

gaaaccccca acagcgagaa cggcacctgt taccccggcg acttcgccga ctacgaggaa      420

ctgcgcgagc agctgagcag cgtgtccagc ttcgagagat tcgagatctt ccccaagacc      480

agcagctggc ccaaccacga cgtgaccaag ggcgtgaccg ctagctgtag ccacgcaggc      540

gccagcagct tctacaagaa cctgctgtgg ctgaccaaga agaacggcag ctaccccaag      600

ctgagcaaga gctacatcaa caacaaagaa aaagaggtgc tggtcctctg gggcgtccac      660

caccccagca caatcgccga ccagcagagc ctgtaccaga acgagaacgc ctacgtgtcc      720

gtgggcagca gccactacag ccggaagttc acccccgaga tcgccaagcg gcccaaagtg      780

cgggaccagg aaggccggat caactactac tggaccctgc tggaacccgg cgacaccatc      840

atcttcgagg ccaacggcaa cctgatcgcc cccagatacg ccttcgccct gagcagaggc      900

ttcggcagcg gcatcatcat cagcaacgcc cccatgcacg actgcgacac caagtgccag      960

acccctcagg gcgccatcaa cagcagcctg cccttccaga acatccaccc cgtgaccatc     1020

ggcgagtgcc ccaaatacgt gcggagcacc aagctgcgga tggccaccgg cctgcggaac     1080

atccccagca tccagagcag aggcctgttc ggcgccattg ccggcttcat cgagggcggc     1140

tggaccggaa tggtggacgg gtggtacggc taccaccacc agaatgagca gggcagcggc     1200

tacgccgccg accagaagtc cacccagaac gccatcgacg gcatcaccaa caaagtgaac     1260

agcgtgatcg agaagatgaa cacccagttc accgccgtgg gcaaagagtt caacaagctg     1320

gaaaagcgga tggaaaacct gaacaagaag gtggacgacg gcttcctgga catctggacc     1380

tacaacgccg aactgctcgt gctgctggaa aacgagcgga ccctggactt ccacgacagc     1440

aacgtgaaga acctgtacga gaaagtgaag tcccagctga agaacaacgc caaagagatc     1500

ggcaacggct gcttcgagtt ctaccacaag tgcaacaacg agtgcatgga aagcgtgaag     1560

aacggaacct acgactaccc caagtacagc gaggaaagca agctgaaccg ggaagagatc     1620

gacggcgtga agctggaatc catgggcgtg taccagatcc tggccatcta cagcaccgtg     1680

gctagcagcc tggtgctgct ggtgtccctg ggcgccatct ccttttggat gtgctccaac     1740

ggcagcctgc agtgccggat ctgcatctac ccctacgacg tgcccgacta cgcctgatga     1800

ctcgagctc                                                             1809


<210>  12
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE-U2-HATantigen amino acid Sequence

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Ala Ala Thr 
            20                  25                  30          


Asn Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp 
        35                  40                  45              


Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val 
    50                  55                  60                  


Asn Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Lys Gly 
65                  70                  75                  80  


Ile Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu 
                85                  90                  95      


Gly Asn Pro Glu Cys Glu Ser Leu Ser Ser Lys Ser Ser Trp Ser Tyr 
            100                 105                 110         


Ile Val Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp 
        115                 120                 125             


Phe Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser 
    130                 135                 140                 


Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His 
145                 150                 155                 160 


Asp Val Thr Lys Gly Val Thr Ala Ser Cys Ser His Ala Gly Ala Ser 
                165                 170                 175     


Ser Phe Tyr Lys Asn Leu Leu Trp Leu Thr Lys Lys Asn Gly Ser Tyr 
            180                 185                 190         


Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asn Lys Glu Lys Glu Val Leu 
        195                 200                 205             


Val Leu Trp Gly Val His His Pro Ser Thr Ile Ala Asp Gln Gln Ser 
    210                 215                 220                 


Leu Tyr Gln Asn Glu Asn Ala Tyr Val Ser Val Gly Ser Ser His Tyr 
225                 230                 235                 240 


Ser Arg Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp 
                245                 250                 255     


Gln Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp 
            260                 265                 270         


Thr Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala 
        275                 280                 285             


Phe Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Ile Ser Asn Ala 
    290                 295                 300                 


Pro Met His Asp Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile 
305                 310                 315                 320 


Asn Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu 
                325                 330                 335     


Cys Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Ala Thr Gly Leu 
            340                 345                 350         


Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly 
    370                 375                 380                 


Tyr His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys 
385                 390                 395                 400 


Ser Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val 
                405                 410                 415     


Ile Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn 
            420                 425                 430         


Lys Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly 
        435                 440                 445             


Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu 
    450                 455                 460                 


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
465                 470                 475                 480 


Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser 
            500                 505                 510         


Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys 
        515                 520                 525             


Leu Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val 
    530                 535                 540                 


Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu 
545                 550                 555                 560 


Leu Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser 
                565                 570                 575     


Leu Gln Cys Arg Ile Cys Ile Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            580                 585                 590         


<210>  13
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BHA DNA Sequence

<400>  13
aaggccatca tcgtgctgct gatggtggtc acaagcaacg ccgaccggat ctgcaccggc       60

atcaccagca gcaacagccc ccacgtggtc aaaaccgcca cccagggcga agtgaacgtg      120

accggcgtga tccccctgac caccaccccc accaagagcc acttcgccaa cctgaagggc      180

accaagaccc ggggaaagct gtgccccaag tgcctgaact gcaccgacct ggacgtggcc      240

ctgggcagac ctatgtgcgt gggcaccacc cctagcgcca aggccagcat cctgcacgaa      300

gtgcggcccg tgaccagcgg ctgcttcccc atcatgcacg accggaccaa gatccggcag      360

ctccccaacc tgctgcgggg ctacgagaac atccggctga gcacccagaa cgtgatcaac      420

gccgagaagg cccctggcgg cccttacaga ctgggcacaa gcggctcttg ccccaacgcc      480

accagcaaga gcggcttttt cgccacaatg gcctgggccg tgcccaagga caacaacaag      540

accgccacca accccctgac cgtggaagtg ccctacatct gcaccgaggg cgaggaccag      600

atcaccgtgt ggggcttcca cagcgataac aagacccaga tgaagaacct gtacggcgac      660

agcaaccccc agaagttcac cagctccgcc aacggcgtga ccacccacta cgtgtcccag      720

atcggcggct tccccgacca gacagaggat ggcggcctgc cccagagcgg cagaatcgtg      780

gtggactaca tggtgcagaa gcccggcaag accggcacca tcgtgtacca gcggggcatc      840

ctgctgcccc agaaagtgtg gtgcgccagc ggccggtcca aagtgatcaa gggcagcctg      900

cctctgatcg gcgaggccga ttgcctgcac gagaagtacg gcggcctgaa caagagcaag      960

ccctactaca ccggcgagca cgccaaagcc atcggcaact gccccatctg ggtcaaaacc     1020

cccctgaagc tggccaacgg caccaagtac cggcctcccg ccaagctgct gaaagagcgg     1080

ggcttcttcg gcgctatcgc cggctttctg gaaggcggct gggagggcat gatcgccggc     1140

tggcacggct acacatctca cggcgctcat ggcgtggccg tggccgctga tctgaagtcc     1200

acccaggaag ccatcaacaa gatcaccaag aacctgaaca gcctgagcga gctggaagtg     1260

aagaatctgc agcggctgag cggcgccatg gacgagctgc acaacgagat cctggaactg     1320

gacgagaagg tggacgacct gcgggccgac accatctcca gccagatcga gctggccgtg     1380

ctgctgtcca acgagggcat catcaacagc gaggacgagc atctgctggc cctggaacgg     1440

aagctgaaga agatgctggg ccctagcgcc gtggacatcg gcaacggctg cttcgagaca     1500

aagcacaagt gcaaccagac ctgcctggac cggatcgctg ccggcacctt caacgccggc     1560

gagttcagcc tgcccacctt cgacagcctg aacatcaccg ccgccagcct gaacgacgac     1620

ggcctggaca accacaccat cctgctgtac tacagcaccg cagcctccag cctggccgtg     1680

accctgatga tcgccatctt catcgtgtac atggtgtctc gggacaacgt gtcctgcagc     1740

atctgcctg                                                             1749


<210>  14
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHA Amino Acid Sequence

<400>  14

Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp Arg 
1               5                   10                  15      


Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys Thr 
            20                  25                  30          


Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr Thr 
        35                  40                  45              


Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr Arg 
    50                  55                  60                  


Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val Ala 
65                  70                  75                  80  


Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala Ser 
                85                  90                  95      


Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile Met 
            100                 105                 110         


His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly Tyr 
        115                 120                 125             


Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asn Ala Glu Lys Ala 
    130                 135                 140                 


Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn Ala 
145                 150                 155                 160 


Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro Lys 
                165                 170                 175     


Asp Asn Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
            180                 185                 190         


Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
        195                 200                 205             


Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln 
    210                 215                 220                 


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
225                 230                 235                 240 


Ile Gly Gly Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser 
                245                 250                 255     


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
            260                 265                 270         


Thr Ile Val Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys 
        275                 280                 285             


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
    290                 295                 300                 


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
305                 310                 315                 320 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
                325                 330                 335     


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
            340                 345                 350         


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
        355                 360                 365             


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
    370                 375                 380                 


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
385                 390                 395                 400 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
                405                 410                 415     


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
            420                 425                 430         


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
        435                 440                 445             


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    450                 455                 460                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
465                 470                 475                 480 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
                485                 490                 495     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            500                 505                 510         


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        515                 520                 525             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
    530                 535                 540                 


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
545                 550                 555                 560 


Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn 
                565                 570                 575     


Val Ser Cys Ser Ile Cys Leu 
            580             


<210>  15
<211>  1865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgE-BHA-HATantigen DNA Sequence

<400>  15
ggtaccggat ccgccaccat ggactggacc tggattctgt tcctggtggc cgctgccaca       60

cgggtgcaca gcaaggccat catcgtgctg ctgatggtgg tcacaagcaa cgccgaccgg      120

atctgcaccg gcatcaccag cagcaacagc ccccacgtgg tcaaaaccgc cacccagggc      180

gaagtgaacg tgaccggcgt gatccccctg accaccaccc ccaccaagag ccacttcgcc      240

aacctgaagg gcaccaagac ccggggaaag ctgtgcccca agtgcctgaa ctgcaccgac      300

ctggacgtgg ccctgggcag acctatgtgc gtgggcacca cccctagcgc caaggccagc      360

atcctgcacg aagtgcggcc cgtgaccagc ggctgcttcc ccatcatgca cgaccggacc      420

aagatccggc agctccccaa cctgctgcgg ggctacgaga acatccggct gagcacccag      480

aacgtgatca acgccgagaa ggcccctggc ggcccttaca gactgggcac aagcggctct      540

tgccccaacg ccaccagcaa gagcggcttt ttcgccacaa tggcctgggc cgtgcccaag      600

gacaacaaca agaccgccac caaccccctg accgtggaag tgccctacat ctgcaccgag      660

ggcgaggacc agatcaccgt gtggggcttc cacagcgata acaagaccca gatgaagaac      720

ctgtacggcg acagcaaccc ccagaagttc accagctccg ccaacggcgt gaccacccac      780

tacgtgtccc agatcggcgg cttccccgac cagacagagg atggcggcct gccccagagc      840

ggcagaatcg tggtggacta catggtgcag aagcccggca agaccggcac catcgtgtac      900

cagcggggca tcctgctgcc ccagaaagtg tggtgcgcca gcggccggtc caaagtgatc      960

aagggcagcc tgcctctgat cggcgaggcc gattgcctgc acgagaagta cggcggcctg     1020

aacaagagca agccctacta caccggcgag cacgccaaag ccatcggcaa ctgccccatc     1080

tgggtcaaaa cccccctgaa gctggccaac ggcaccaagt accggcctcc cgccaagctg     1140

ctgaaagagc ggggcttctt cggcgctatc gccggctttc tggaaggcgg ctgggagggc     1200

atgatcgccg gctggcacgg ctacacatct cacggcgctc atggcgtggc cgtggccgct     1260

gatctgaagt ccacccagga agccatcaac aagatcacca agaacctgaa cagcctgagc     1320

gagctggaag tgaagaatct gcagcggctg agcggcgcca tggacgagct gcacaacgag     1380

atcctggaac tggacgagaa ggtggacgac ctgcgggccg acaccatctc cagccagatc     1440

gagctggccg tgctgctgtc caacgagggc atcatcaaca gcgaggacga gcatctgctg     1500

gccctggaac ggaagctgaa gaagatgctg ggccctagcg ccgtggacat cggcaacggc     1560

tgcttcgaga caaagcacaa gtgcaaccag acctgcctgg accggatcgc tgccggcacc     1620

ttcaacgccg gcgagttcag cctgcccacc ttcgacagcc tgaacatcac cgccgccagc     1680

ctgaacgacg acggcctgga caaccacacc atcctgctgt actacagcac cgcagcctcc     1740

agcctggccg tgaccctgat gatcgccatc ttcatcgtgt acatggtgtc tcgggacaac     1800

gtgtcctgca gcatctgcct gtacccctac gacgtgcccg actacgctga tgactcgagc     1860

tcctc                                                                 1865


<210>  16
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE-BHA-HATantigen Amino Acid Sequence

<400>  16

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala 
            20                  25                  30          


Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
        35                  40                  45              


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
    50                  55                  60                  


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys 
65                  70                  75                  80  


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
                85                  90                  95      


Val Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys 
            100                 105                 110         


Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
        115                 120                 125             


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
    130                 135                 140                 


Gly Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asn Ala Glu 
145                 150                 155                 160 


Lys Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro 
                165                 170                 175     


Asn Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
            180                 185                 190         


Pro Lys Asp Asn Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val 
        195                 200                 205             


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
    210                 215                 220                 


His Ser Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn 
225                 230                 235                 240 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
                245                 250                 255     


Ser Gln Ile Gly Gly Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro 
            260                 265                 270         


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys 
        275                 280                 285             


Thr Gly Thr Ile Val Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
    290                 295                 300                 


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
305                 310                 315                 320 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
                325                 330                 335     


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
            340                 345                 350         


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
        355                 360                 365             


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
    370                 375                 380                 


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
385                 390                 395                 400 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
                405                 410                 415     


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
            420                 425                 430         


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
        435                 440                 445             


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
    450                 455                 460                 


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
465                 470                 475                 480 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
                485                 490                 495     


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly 
            500                 505                 510         


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
        515                 520                 525             


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
    530                 535                 540                 


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
545                 550                 555                 560 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
                565                 570                 575     


Ala Val Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg 
            580                 585                 590         


Asp Asn Val Ser Cys Ser Ile Cys Leu Tyr Pro Tyr Asp Val Pro Asp 
        595                 600                 605             


Tyr Ala 
    610 


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE Leader Amino Acid Sequence

<400>  17

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag amino acid sequence

<400>  18

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  19
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX2012 H1HA-ConBris DNA Sequence

<400>  19
atgaaggtga aactgctggt gctgctgtgc accttcaccg ccacctacgc cgacaccatc       60

tgcatcggct accacgccaa caacagcacc gacaccgtgg ataccgtgct ggaaaagaac      120

gtgaccgtga cccacagcgt gaacctgctg gaaaacagcc acaacggcaa gctgtgcctg      180

ctgaagggaa tcgcccccct gcagctgggc aattgcagcg tggccggctg gattctgggc      240

aaccccgagt gcgagctgct gatcagcaaa gagtcctggt cctacatcgt ggaaaagccc      300

aaccccgaga acggcacctg ttaccccggc cacttcgccg actacgagga actgcgcgag      360

cagctgagca gcgtgtccag cttcgagaga ttcgagatct tccccaaaga gtctagctgg      420

cccaaccaca ccgtgacagg cgtgtccgcc agctgctccc acaacggcga gagcagcttc      480

taccggaacc tgctgtggct gaccggcaag aacggcctgt accccaacct gagcaagagc      540

tatgccaaca acaaagaaaa agaggtgctg gtgctgtggg gcgtgcacca cccccccaac      600

atcggcgacc agaaggccct gtaccacacc gagaacgcct acgtgtccgt ggtgtccagc      660

cactacagcc ggaagttcac ccccgagatc gccaagcggc ccaaagtgcg ggaccaggaa      720

ggccggatca actactactg gaccctgctg gaacccggcg acaccatcat cttcgaggcc      780

aacggcaacc tgatcgcccc cagatacgcc ttcgccctga gcagaggctt cggcagcggc      840

atcatcaaca gcaacgcccc catggacaag tgcgacgcca agtgccagac cccccagggc      900

gccatcaaca gctccctgcc cttccagaac gtgcaccccg tgaccatcgg cgagtgcccc      960

aaatacgtgc ggagcgccaa gctgcggatg gtgacaggcc tgcggaacat ccccagcatc     1020

cagagcagag gcctgttcgg cgccattgcc ggcttcatcg agggcggctg gaccggaatg     1080

gtggacgggt ggtacggcta ccaccaccag aacgagcagg gcagcggcta cgccgccgac     1140

cagaagtcca cccagaacgc catcaacggc atcaccaaca aagtgaacag cgtgatcgag     1200

aagatgaaca cccagttcac cgccgtgggc aaagagttca acaagctgga acggcggatg     1260

gaaaacctga acaagaaggt ggacgacggc tttatcgaca tctggaccta caacgccgag     1320

ctgctggtcc tgctggaaaa cgagcggacc ctggacttcc acgacagcaa cgtgaagaac     1380

ctgtacgaga aagtgaagtc ccagctgaag aacaacgcca aagagatcgg caacggctgc     1440

ttcgagttct accacaagtg caacgacgag tgcatggaaa gcgtgaagaa tggcacctac     1500

gactacccca agtacagcga ggaaagcaag ctgaaccgcg agaagatcga cggcgtgaag     1560

ctggaatcca tgggcgtgta ccagatcctg gccatctaca gcaccgtggc cagcagcctg     1620

gtcctgctgg tgtccctggg cgccatctcc ttttggatgt gctccaacgg cagcctgcag     1680

tgccggatct gcatctga                                                   1698


<210>  20
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pGX2012 H1HA-ConBris Protein Sequence

<400>  20

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Lys Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Lys Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  21
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX2015 H1HA-ConTT DNA Sequence

<400>  21
aaggcaaaac tgctggtgct gctgtgcgca ttcaccgcca catacgctga cacaatctgc       60

attggctatc acgccaacaa ttccactgac accgtggata ctgtcctgga gaagaacgtg      120

acagtcactc acagcgtgaa cctgctggaa gattcccata atggaaagct gtgccggctg      180

aaaggcatcg ctcctctgca gctggggaac tgctctgtgg cagggtggat tctgggaaat      240

ccagagtgtg aaagcctgtt ttccaaggag tcatggagct acatcgccga gacccccaac      300

cctgaaaatg gcacatgcta ccctgggtat ttcgctgact atgaggaact gcgggagcag      360

ctgagctccg tgtctagttt cgagagattt gaaatcttcc caaaggaatc aagctggccc      420

aaccacaccg tgacaaaggg agtcactgcc tcctgttctc ataacggcaa atcctctttt      480

taccgaaatc tgctgtggct gacagagaaa aacggcctgt acccaaatct gagtaagtca      540

tacgtgaaca ataaggagaa agaagtgctg gtcctgtggg gggtccacca tccctccaac      600

atcggagacc agcgcgccat ctaccacacc gagaatgctt acgtgagcgt ggtcagttca      660

cattacagcc ggcggttcac ccctgagatc gccaagcgac caaaagtgcg ggaccaggaa      720

ggcaggatta actactattg gactctgctg gagccagggg ataccatcat tttcgaagca      780

aacggaaatc tgatcgcccc ctggtatgca tttgccctga gtcgcggatt cggctcaggg      840

atcattacct ctaatgcaag tatgggcgag tgcgatgcca agtgtcagac accacagggg      900

gctatcaaca gctccctgcc cttccagaat gtgcaccctg tcaccattgg agagtgcccc      960

aaatacgtga gaagcacaaa gctgaggatg gtcactggcc tgcgcaacat cccttcaatt     1020

cagagccgag gcctgtttgg ggctatcgca ggcttcattg agggcgggtg gaccgggatg     1080

atcgacggat ggtacggcta tcaccatcag aatgaacagg gatcaggcta cgccgctgat     1140

cagaagagca cacagaacgc aatcaatggg attactaaca aagtgaatag cgtcatcgag     1200

aagatgaaca ctcagtttac cgccgtggga aaggagttca acaagctgga gaggcgcatg     1260

gaaaacctga ataagaaagt ggacgatggc tttctggata tttggactta caacgctgag     1320

ctgctggtgc tgctggagaa tgaaagaacc ctggacttcc acgattccaa cgtgaagaat     1380

ctgtatgaaa aggtcaaatc tcagctgaag aacaatgcaa aagagatcgg gaacggatgt     1440

ttcgagttct accataaatg caacaatgag tgtatggaat ctgtgaaaaa cgggacctac     1500

gactatccca agtattccga ggaatctaag ctgaataggg agaaaatcga tggagtgaag     1560

ctggaaagta tgggcgtcta ccagatcctg gctatctaca gcacagtggc atctagtctg     1620

gtgctgctgg tcagcctggg cgctatctcc ttctggatgt gctcaaatgg gtctctgcag     1680

tgccgcatct gtatctaatg a                                               1701


<210>  22
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pGX2015 H1HA-ConTT Protein Sequence

<400>  22

Lys Ala Lys Leu Leu Val Leu Leu Cys Ala Phe Thr Ala Thr Tyr Ala 
1               5                   10                  15      


Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val 
            20                  25                  30          


Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu 
        35                  40                  45              


Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile Ala 
    50                  55                  60                  


Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly Asn 
65                  70                  75                  80  


Pro Glu Cys Glu Ser Leu Phe Ser Lys Glu Ser Trp Ser Tyr Ile Ala 
                85                  90                  95      


Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe Ala 
            100                 105                 110         


Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu 
        115                 120                 125             


Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr Val 
    130                 135                 140                 


Thr Lys Gly Val Thr Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Ser Asn Ile Gly Asp Gln Arg Ala Ile Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


Gly Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  23
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX2016 H3HA-V2 DNA Sequence

<400>  23
atgaagacca tcattgccct gagctacatc ctgtgcctgg tgttcgccca gaagctgccc       60

ggcaacgaca acagcaccgc caccctgtgt ctgggccacc acgccgtgcc caacggcacc      120

ctggtgaaaa ccatcaccaa cgaccagatc gaagtgacca acgccaccga gctggtgcag      180

agcagcagca ccggcagaat ctgcgacagc ccccacagaa tcctggacgg cgagaactgc      240

accctgatcg acgccctgct gggcgatccc cactgcgacg gcttccagaa caaagaatgg      300

gacctgttcg tggaacggtc caaggcctac agcaactgct acccctacga cgtgcccgac      360

tacgccagcc tgagaagcct ggtggccagc agcggcacac tggaattcaa caacgagagc      420

ttcaactgga ccggcgtggc ccagaacggc accagcagcg cctgcaagcg gcggagcgtg      480

aagtccttct tctcccggct gaactggctg caccagctga agtacaagta ccccgccctg      540

aacgtgacca tgcccaacaa tgagaagttc gacaagctgt acatctgggg cgtgcaccac      600

cctagcaccg acagcgacca gaccagcctg tacgcccagg ccagcggcag agtgaccgtg      660

tccaccaagc ggagccagca gaccgtgatc cccaacatcg gcagcagacc ttgggtccgc      720

ggcgtgtcca gccggatcag catctactgg accatcgtga agcccggcga catcctgctg      780

atcaactcca ccggcaacct gatcgccccc agaggctact tcaagatcag aagcggcaag      840

agcagcatca tgagaagcga cgcccccatc ggcaagtgca acagcgagtg catcaccccc      900

aacggcagca tccccaacga caagcccttc cagaacgtga accggatcac ctacggcgcc      960

tgccccagat acgtgaagca gaacaccctg aagctggcca ccggcatgcg gaacgtgccc     1020

gagaagcaga cccggggcat ctttggcgcc attgccggct tcatcgagaa cggctgggag     1080

ggcatggtgg acgggtggta cggcttccgg caccagaata gcgagggcac aggccaggcc     1140

gccgacctga aaagcaccca ggccgccatc aaccagatca acggcaagct gaaccggctg     1200

atcgaaaaga ccaacgagaa gttccaccag atcgagaaag aattcagcga ggtggaaggc     1260

agaatccagg acctggaaaa gtacgtggaa gataccaaga tcgacctgtg gtcctacaac     1320

gccgagctgc tggtggccct ggaaaaccag cacaccatcg acctgaccga ctccgagatg     1380

aacaagctgt tcgagcggac ccggaagcag ctgcgcgaga acgccgagga catgggcaac     1440

ggctgcttta agatctacca caagtgcgac aacgcctgca tcggctccat ccggaacggc     1500

acctacgacc acgacgtgta ccgggacgag gccctgaaca accggttcca gatcaagggc     1560

gtggaactga agtccggcta caaggactgg attctgtgga tcagcttcgc catcagctgc     1620

tttctgctgt gcgtggtgct gctgggcttc atcatgtggg cctgccagaa gggcaacatc     1680

cgctgcaaca tctgcatctg a                                               1701


<210>  24
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pGX2016 H3HA-V2 Protein Sequence

<400>  24

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Ala Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Val 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu His Gln Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Asp Gln Thr 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Val Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  25
<211>  1758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX2014 B-HA-V2 DNA Sequence

<400>  25
atgaaggcca tcatcgtgct gctgatggtg gtgacaagca acgccgaccg gatctgcacc       60

ggcatcacca gcagcaacag cccccacgtg gtgaaaaccg ccacccaggg cgaagtgaac      120

gtgaccggcg tgatccccct gaccaccacc cccaccaaga gccacttcgc caacctgaag      180

ggcaccgaga cacggggcaa gctgtgtccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggca gacccaagtg caccggcaac atccccagcg ccagagtgtc catcctgcac      300

gaagtgcggc ccgtgacctc cggctgcttc cctatcatgc acgaccggac caagatcaga      360

cagctgccta acctgctgcg gggctacgag cacatccggc tgagcaccca caacgtgatc      420

aacgccgaga acgcccctgg cggcccttac aagatcggca ccagcggaag ctgccccaac      480

gtgacaaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccaa gaacgacaac      540

aacaagacag ccaccaacag cctgaccatc gaggtgccct acatctgcac cgagggcgag      600

gaccagatca ccgtgtgggg cttccacagc gacaacgaga cacagatggc caagctgtac      660

ggcgacagca agccccagaa gttcaccagc tccgccaacg gcgtgaccac ccactacgtg      720

tcccagatcg gcggcttccc caaccagacc gaggatggcg gcctgcccca gagcggcaga      780

atcgtggtgg actacatggt gcagaagtcc ggcaagaccg gcaccatcac ctaccagcgg      840

ggcatcctgc tgccccagaa agtgtggtgc gccagcggcc ggtccaaagt gatcaaggga      900

agcctgcccc tgatcggcga ggccgattgc ctgcacgaga agtacggcgg cctgaacaag      960

agcaagccct actacaccgg cgagcacgcc aaggccatcg gcaactgccc catctgggtg     1020

aaaacccccc tgaagctggc caacggcacc aagtaccggc ctcccgccaa gctgctgaaa     1080

gagcggggct tcttcggcgc tatcgccggc tttctggaag gcggctggga gggcatgatc     1140

gccggctggc acggctacac atctcacggc gctcatggcg tggccgtggc cgccgatctg     1200

aagtccaccc aggaagccat caacaagatc accaagaacc tgaacagcct gagcgagctg     1260

gaagtgaaga acctgcagcg gctgagcggc gccatggacg agctgcacaa cgagatcctg     1320

gaactggacg agaaggtgga cgacctgcgg gccgacacca tctccagcca gatcgagctg     1380

gccgtgctgc tgtccaacga gggcatcatc aacagcgagg acgagcatct gctggccctg     1440

gaacggaagc tgaagaagat gctgggcccc tccgccgtgg aaatcggcaa tggctgcttc     1500

gagacaaagc acaagtgcaa ccagacctgc ctggaccgga tcgctgccgg caccttcgat     1560

gccggcgagt tcagcctgcc caccttcgac agcctgaaca tcaccgccgc cagcctgaac     1620

gacgacggcc tggacaacca caccatcctg ctgtactaca gcaccgccgc ctccagcctg     1680

gccgtgaccc tgatgatcgc catcttcgtg gtgtacatgg tgtccagaga caacgtgtcc     1740

tgcagcatct gcctgtga                                                   1758


<210>  26
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pGX2014 B-HA-V2 protein Sequence

<400>  26

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  27
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3HA-V3 DNA Sequence

<400>  27
atgaaaacaa tcatcgccct gtcctacatc ctgtgcctgg tctttgccca gaaactgccc       60

gggaacgaca actcaactgc tacactgtgt ctgggccacc atgccgtgcc taacgggacc      120

ctggtcaaga ccattacaaa cgaccagatc gaagtgacta atgctaccga actggtccag      180

agctcctcta ccggacgcat ttgcgacagc ccacaccgaa tcctggatgg caaaaattgt      240

acactgatcg acgcactgct gggagacccc cattgcgatg gcttccagaa caaggagtgg      300

gatctgtttg tggaacgcag taaagcttac tcaaattgtt acccctatga cgtgcctgat      360

tatgcatccc tgcgatctct ggtcgccagt tcagggactc tggagttcat caacgaagac      420

tttaattgga ccggagtggc tcaggatggc gggtcctacg catgcaagag aggcagtgtc      480

aactcattct ttagcaggct gaattggctg cacaagctgg agtacaaata tcccgccctg      540

aacgtgacta tgcctaacaa tgggaagttc gacaaactgt acatctgggg agtgcaccat      600

ccctccactg actctgatca gacctcactg tatgtccggg ccagcggcag agtgacagtc      660

agcactaagc ggtcccagca gacagtgatc cctaatattg gaagtaggcc atgggtccgc      720

ggcctgagct ccagaatctc aatctactgg acaatcgtga aacctggcga tatcctgctg      780

attaacagca ctgggaatct gattgctcca agaggatatt tcaagattag gaccggcaaa      840

tctagtatca tgcggagcga cgcaccaatt ggcaactgct caagcgagtg tattactccc      900

aacgggtcca tcccaaatga taagcccttt cagaacgtga ataggatcac ctacggggcc      960

tgtccccgct atgtcaagca gaacacactg aaactggcta ctggaatgcg aaatgtgcct     1020

gagaaacaga cccggggcat cttcggggct attgcaggct ttatcgagaa cggatgggaa     1080

ggcatggtgg acgggtggta cggattcaga caccagaatt ccgagggaac cggacaggca     1140

gctgacctga agtctacaca ggcagccatc gatcagatta acggcaaact gaataggctg     1200

atcgagaaga caaacgaaaa attccatcag attgagaagg agttcagcga ggtggaaggg     1260

cgcatccagg atctggagaa gtacgtcgaa gacactaaaa ttgatctgtg gtcttataac     1320

gccgagctgc tggtggctct ggaaaatcag cacaccatcg acctgacaga tagtgagatg     1380

aataagctgt tcgaaaagac ccgaaaacag ctgcgggaga acgcagaaga catggggaat     1440

ggatgcttta agatctacca caaatgcgat aacgcctgta tcggctctat taggaatggg     1500

acatacgacc atgacgtgta ccgggacgag gccctgaaca atagatttca gatcaagggg     1560

gtggaactga agagcggata caaggattgg attctgtgga tctctttcgc cattagttgc     1620

tttctgctgt gcgtggtcct gctgggattc attatgtggg cttgtcagaa aggaaatatt     1680

cggtgtaaca tctgcatttg ataa                                            1704


<210>  28
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3HA-V3 protein Sequence

<400>  28

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Asp Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Ala Gln Asp Gly Gly Ser Tyr Ala Cys Lys Arg Gly Ser Val 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu His Lys Leu Glu Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Gly Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Asp Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Arg Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Asn Cys Ser Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  29
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3HA-V4 DNA Sequence

<400>  29
atgaaaacaa tcatcgccct gtcctacatc ctgtgcctgg tctttgctca gaaactgcct       60

ggaaatgaca actctactgc tacactgtgt ctgggacacc atgcagtgcc aaacggcacc      120

atcgtcaaaa ccattacaaa cgaccagatc gaagtgacta atgctaccga actggtccag      180

agctcctcta caggagagat ttgcgacagc ccccaccaga tcctggatgg cgaaaattgt      240

actctgattg acgcactgct gggggaccct cagtgcgatg gattccagaa caagaaatgg      300

gatctgtttg tggagcggtc caaggcctac tctaattgtt acccctatga cgtgcctgat      360

tatgcttcac tgagaagcct ggtcgcaagt tcaggcaccc tggagttcaa caatgaatcc      420

tttaactgga caggggtgac tcagaatgga acaagctccg cctgcatccg gagatccaac      480

aattctttct ttagtcgcct gaactggctg acccatctga agttcaaata ccctgccctg      540

aatgtgacaa tgccaaacaa tgagcagttt gacaagctgt atatctgggg cgtccaccat      600

ccaggaaccg acaacgatca gatcttcctg tacgctcaag caagtggcag gattaccgtg      660

agtacaaaac gctcacagca gacagtcatc cctaacattg ggtcaaggcc acgcgtgcga      720

aatatcccct caagaatcag catctactgg actattgtca agccaggcga tatcctgctg      780

attaacagca ccgggaatct gatcgccccc agaggatact tcaagattag atctggcaaa      840

tctagtatca tgaggagtga cgctcccatt ggcaagtgca actcagagtg tattactcct      900

aacgggagca tcccaaatga taaacccttt cagaacgtga atagaatcac ctacggggca      960

tgtcctagat atgtcaagca gaacacactg aaactggcca ctggaatgcg caatgtgcca     1020

gagaagcaga cccgagggat cttcggagcc attgctggct ttatcgagaa cggctgggaa     1080

gggatggtgg acggatggta cggcttccgg caccagaatt ccgagggaat cggacaggca     1140

gctgacctga agtctacaca ggcagccatc gatcagatta acgggaaact gaataggctg     1200

atcggaaaga ctaacgaaaa gttccatcag atcgagaagg aattttccga ggtggaaggc     1260

cgcatccagg atctggagaa gtacgtcgaa gacaccaaaa ttgatctgtg gtcttataac     1320

gcagagctgc tggtggccct ggaaaatcag cacactatcg acctgaccga tagtgagatg     1380

aataagctgt tcgaaaagac taagaaacag ctgcgagaga acgctgaaga catgggaaat     1440

ggctgcttta agatctacca caaatgcgat aacgcatgta tcggatctat tcggaatggc     1500

acatacgacc atgacgtgta ccgagacgag gccctgaaca atcggtttca gatcaagggc     1560

gtcgaactga agtccgggta caaagattgg attctgtgga ttagcttcgc catttcctgc     1620

tttctgctgt gcgtggctct gctgggattc attatgtggg cctgtcagaa aggaaatatt     1680

cggtgtaaca tttgcatctg ataa                                            1704


<210>  30
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3HA-V4 protein Sequence

<400>  30

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  31
<211>  1755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-HA-V3 DNA Sequence

<400>  31
atgaaggcta ttattgtcct gctgatggtc gtcacatcta acgctgatcg catctgcacc       60

ggaattacct cctctaactc tcctcacgtg gtcaagacag ccactcaggg agaagtgaat      120

gtcaccggcg tgatccctct gaccacaact ccaacaaagt cccactttgc taacctgaag      180

gggaccaaaa caaggggaaa actgtgcccc aactgtctga attgcaccga cctggatgtg      240

gccctggggc gccctatgtg catcggaacc acaccatcag caaaagccag cattctgcac      300

gaggtgcgac ccgtcacttc tggctgcttc cctatcatgc atgaccggac caagattaga      360

cagctgccta atctgctgag ggggtacgaa aacatccgcc tgtccactca taacgtgatt      420

aatgctgagc gagcaccagg cgggccatat cgactgggca cttccggatc ttgtcccaac      480

gtgaccagtc gctcaggctt ctttgccaca atggcttggg cagtccctcg agacaacaag      540

actgctacca atcccctgac agtggaagtc ccttacatct gcaccaaagg ggaggaccag      600

attacagtgt ggggatttca cagcgataac aagacacaga tgaaaaatct gtacggggat      660

tccaaccccc agaagttcac cagctccgcc aatggagtga ctacccatta tgtctcccag      720

atcggaggct tcccaaacca gaccgaggac gggggactgc cacagtctgg ccgcatcgtg      780

gtcgattaca tggtgcagaa gcctggaaaa acaggcacta tcgtgtacca gcggggagtc      840

ctgctgccac agaaagtgtg gtgtgcttct ggcagaagta aggtcatcaa aggcagtctg      900

ccactgattg gggaagcaga ctgcctgcac gagaagtatg gcgggctgaa taagtccaaa      960

ccctactata ccggagaaca tgccaaagct atcggcaatt gtccaatttg ggtgaagact     1020

cccctgaaac tggcaaacgg caccaagtac agaccccctg ccaagctgct gaaagagagg     1080

gggttctttg gagcaatcgc cggctttctg gaaggaggct gggaggggat gattgccggc     1140

tggcacgggt atacatctca cggagcacat ggagtggctg tcgcagctga cctgaagagt     1200

acacaggaag ctatcaacaa gatcactaag aacctgaata gcctgtccga gctggaagtg     1260

aaaaatctgc agcgcctgag cggcgccatg gatgagctgc ataacgagat cctggaactg     1320

gacgagaagg tggacgatct gcgggctgat accatctcta gtcagattga actggcagtc     1380

ctgctgagta acgagggaat cattaattca gaggatgaac acctgctggc actggaaaga     1440

aagctgaaga aaatgctggg gcctagcgcc gtggacatcg ggaatggatg cttcgagact     1500

aagcataaat gtaaccagac ctgcctggat aggattgcag ccggcacctt caatgccggg     1560

gagttttccc tgccaacatt cgactctctg aacatcactg ctgcatcact gaatgacgat     1620

ggcctggata accacaccat tctgctgtac tatagcacag ccgcttcaag cctggccgtg     1680

acactgatga tcgctatttt catcgtgtat atggtgtcca gagataatgt ctcctgtagt     1740

atttgcctgt gataa                                                      1755


<210>  32
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-HA-V3 protein Sequence

<400>  32

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Ile Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Arg 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Ser Arg Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Arg Asp Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
            180                 185                 190         


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
        195                 200                 205             


Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln 
    210                 215                 220                 


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
225                 230                 235                 240 


Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser 
                245                 250                 255     


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
            260                 265                 270         


Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
        275                 280                 285             


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
    290                 295                 300                 


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
305                 310                 315                 320 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
                325                 330                 335     


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
            340                 345                 350         


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
        355                 360                 365             


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
    370                 375                 380                 


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
385                 390                 395                 400 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
                405                 410                 415     


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
            420                 425                 430         


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
        435                 440                 445             


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    450                 455                 460                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
465                 470                 475                 480 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
                485                 490                 495     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            500                 505                 510         


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        515                 520                 525             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
    530                 535                 540                 


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
545                 550                 555                 560 


Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn 
                565                 570                 575     


Val Ser Cys Ser Ile Cys Leu 
            580             


<210>  33
<211>  1761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-HA-V4 DNA Sequence

<400>  33
atgaaggcaa ttatcgtcct gctgatggtg gtgacctcaa acgccgacag aatctgcaca       60

ggcattacct cctcaaatag tccccatgtg gtcaagactg ccacccaggg ggaagtgaat      120

gtcactggag tgatccctct gaccacaact ccaaccaaat cccactttgc taacctgaag      180

ggcacaaaaa ctcgcgggaa gctgtgcccc aaatgtctga attgcaccga cctggatgtg      240

gctctgggcc gaccaaagtg tacagggaac atcccctctg caaaagtcag tattctgcac      300

gaggtgaggc ctgtcacaag tggatgcttc ccaatcatgc atgaccggac taagattaga      360

cagctgccta atctgctgag gggctacgaa cacatccgcc tgtccacaca taacgtgatt      420

aatgcagaga aggccccagg cgggccctat aaaatcggaa catccggctc ttgtccaaac      480

gtgactaacg ggaatggatt ctttgcaacc atggcatggg ccgtccccaa gaacgacaac      540

aacaagaccg ccacaaattc tctgaccatc gaagtgcctt acatttgcac tgagggcgaa      600

gaccagatca ccgtctgggg gtttcacagc gataacgaga ctcagatggc taagctgtac      660

ggcgattcca agccacagaa gttcaccagc agcgccaacg gggtgaccac acattatgtc      720

tcccagatcg gaggcttccc caatcagacc gaggacgggg gactgcctca gagtggacgg      780

attgtggtcg attacatggt gcagaagtca gggaaaactg gaaccatcac atatcagaga      840

gggattctgc tgccacagaa agtgtggtgt gccagcggaa ggtccaaggt catcaaagga      900

tccctgcccc tgattggcga agctgattgc ctgcacgaga agtatggcgg gctgaataag      960

tctaaaccct actatacagg ggaacatgct aaagcaatcg gaaactgtcc catttgggtg     1020

aagacacctc tgaaactggc caatggcact aagtaccgac cccctgctaa gctgctgaaa     1080

gagcggggct tctttggggc catcgctgga tttctggaag gaggctggga gggcatgatt     1140

gccggatggc acggctatac ctctcacggg gctcatggag tggcagtcgc cgctgacctg     1200

aagagtaccc aggaagccat caacaagatc acaaagaacc tgaatagtct gtcagagctg     1260

gaagtgaaaa acctgcagcg cctgagcggc gccatggatg agctgcataa tgagatcctg     1320

gaactggacg agaaggtgga cgatctgcgg gcagatacca tctctagtca gattgaactg     1380

gccgtgctgc tgtccaacga ggggatcatt aattctgagg acgaacacct gctggccctg     1440

gaaagaaagc tgaagaaaat gctgggccct agcgccgtgg aaatcggcaa cgggtgcttc     1500

gagacaaagc ataaatgtaa tcagacttgc ctggatagga ttgcagccgg aacattcaac     1560

gccggcgagt tttcactgcc aaccttcgac agcctgaata tcacagctgc atcactgaac     1620

gacgatggcc tggataatca cactattctg ctgtactata gcaccgccgc ttcaagcctg     1680

gccgtgactc tgatgatcgc catctttgtg gtgtatatgg tgtccaggga taacgtgtct     1740

tgtagcattt gtctgtgata a                                               1761


<210>  34
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-HA-V4 protein Sequence

<400>  34

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Lys Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  35
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1U consensus DNA sequence

<400>  35
ggtaccaagc ttgccaccat gaaggtgaaa ctgctggtgc tgctgtgcac cttcaccgcc       60

acctacgccg acaccatctg catcggctac cacgccaaca acagcaccga caccgtggat      120

accgtgctgg aaaagaacgt gaccgtgacc cacagcgtga acctgctgga agatagccac      180

aacggcaagc tgtgcctgct gaaaggcatc gcccccctgc agctgggcaa ctgcagcgtg      240

gccggctgga tcctgggcaa ccccgagtgc gagctgctga tttccaaaga aagctggtcc      300

tacatcgtgg agacccccaa ccccgagaac ggcacctgct accccggcta cttcgccgac      360

tacgaggaac tgcgggagca gctgtccagc gtgagcagct tcgagcggtt cgagatcttc      420

cccaaagaga gcagctggcc caaccacacc gtgaccggcg tgagcgccag ctgctcccac      480

aatggcaaga gcagcttcta ccggaacctg ctgtggctga ccggcaagaa cggcctgtac      540

cccaacctga gcaagagcta cgccaataac aaagaaaagg aagtgctggt gctgtggggc      600

gtgcaccacc cccccaacat cggcgaccag cgggccctgt accacaccga gaacgcctac      660

gtgagcgtgg tgtccagcca ctacagccgg cggttcaccc ccgagatcgc caagcggccc      720

aaagtgcggg accaggaagg ccggatcaac tactactgga ccctgctgga acccggcgac      780

accatcatct tcgaggccaa cggcaacctg atcgccccca gatacgcctt cgccctgagc      840

cggggcttcg gcagcggcat catcaccagc aacgccccca tggacgagtg cgacgccaag      900

tgccagaccc ctcagggagc tattaacagc agcctgccct tccagaacgt gcaccccgtg      960

accatcggcg agtgccccaa gtacgtgcgg agcgccaagc tgcggatggt gaccggcctg     1020

cggaacatcc ccagcatcca gagcaggggc ctgttcggcg ccatcgccgg cttcatcgag     1080

ggcggctgga ccggcatggt ggacgggtgg tacggctacc accaccagaa cgagcagggc     1140

agcggctacg ccgccgacca gaagagcacc cagaacgcca tcaacggcat caccaacaag     1200

gtgaacagcg tgatcgagaa gatgaacacc cagttcaccg ccgtgggcaa agagttcaac     1260

aagctggaac ggcggatgga aaacctgaac aagaaggtgg acgacggctt cctggacatc     1320

tggacctaca acgccgagct gctggtgctg ctggaaaacg agcggaccct ggacttccac     1380

gacagcaacg tgaagaacct gtacgagaag gtgaaaagcc agctgaagaa caacgccaaa     1440

gagatcggca acggctgctt cgagttctac cacaagtgca acgacgagtg catggaaagc     1500

gtgaagaatg gcacctacga ctaccccaag tacagcgagg aaagcaagct gaaccgggag     1560

aagatcgacg gcgtgaagct ggaaagcatg ggcgtgtacc agatcctggc catctacagc     1620

accgtcgctt ccagcctcgt cctgctcgtg tccctgggcg ccatctcctt ttggatgtgc     1680

agcaacggca gcctgcagtg ccggatctgc atctgatgac tcgagctc                  1728


<210>  36
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1U consensus protein sequence

<400>  36

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  37
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3HA1 consensus DNA sequence

<400>  37
ggtaccaagc ttgccaccat gaaaaccatc atcgccctga gctacatcct gtgcctggtg       60

ttcgcccaga agctgcccgg caacgacaac agcaccgcca ccctgtgtct gggccaccac      120

gccgtgccca acggcaccat cgtgaaaaca atcaccaacg accagatcga ggtgaccaac      180

gccaccgagc tggtgcagag cagcagcacc ggcggcatct gcgacagccc ccaccagatc      240

ctggacggcg agaactgcac cctgatcgac gccctgctgg gcgaccctca gtgcgacggc      300

ttccagaaca aaaagtggga cctgttcgtg gagcggagca aggcctacag caactgctac      360

ccctacgacg tgcccgacta cgccagcctg cggagcctgg tggccagcag cggcaccctg      420

gaattcaaca acgagagctt caactggacc ggcgtgaccc agaacggcac cagcagcgcc      480

tgcaagcggc ggagcaacaa cagcttcttt tccagactga actggctgac ccacctgaag      540

ttcaagtacc ccgccctgaa cgtgaccatg cccaacaatg agaagttcga caagctgtac      600

atctggggcg tgcaccaccc cggcaccgac aatgaccaga tcagcctgta cgcccaggcc      660

agcggccgga tcaccgtgag caccaagcgg agccagcaga ccgtgatccc caacatcggc      720

agccggccca gagtgagaga catccccagc cggatcagca tctactggac aatcgtgaag      780

cccggcgaca tcctgctgat caactccacc ggcaacctga tcgcccccag gggctacttc      840

aagatcagaa gcggcaagag cagcatcatg cggagcgacg cccccatcgg caagtgcaac      900

agcgagtgca tcacccccaa tggcagcatc cccaacgaca agcccttcca gaacgtgaac      960

cggatcacct acggcgcctg ccccagatac gtgaagcaga acaccctgaa gctggccacc     1020

ggcatgcgga acgtgcccga gaagcagacc cggggcatct tcggcgccat cgccggcttc     1080

atcgagaacg gctgggaggg catggtggac gggtggtacg gcttccggca ccagaactcc     1140

gagggcatcg gccaggccgc cgacctgaag agcacccagg ccgccatcaa ccagatcaac     1200

ggcaagctga accggctgat cggcaagacc aacgagaagt tccaccagat cgaaaaagaa     1260

ttcagcgagg tggagggccg gatccaggac ctggaaaagt acgtggagga caccaagatc     1320

gacctgtgga gctacaacgc cgagctgctg gtcgccctgg aaaaccagca caccatcgac     1380

ctgaccgaca gcgagatgaa caagctgttc gagcggacca agaagcagct gcgggagaac     1440

gccgaggaca tgggcaacgg ctgctttaag atctaccaca agtgcgacaa cgcctgcatc     1500

ggcagcatcc ggaacggcac ctacgaccac gacgtgtacc gggacgaggc cctgaacaac     1560

cggttccaga tcaagggcgt ggagctgaag agcggctaca aggactggat cctgtggatc     1620

agcttcgcca tcagctgctt tctgctgtgc gtggccctgc tgggattcat catgtgggcc     1680

tgccagaagg gcaacatccg ctgcaacatc tgcatctgat gactcgagct c              1731


<210>  38
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3HA1 consensus protein sequence

<400>  38

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


