                         SEQUENCE LISTING

<110>  MERCK SHARP & DOHME CORP.
       Xu, Feng
       Liu, Zhuqing
       Desmond, Richard
       Park, Jeonghan
       Kalinin, Alexei
       Kosjek, Birgit
       Strotman, Hallena
       Li, Hongmei
       Moncecchi, Johannah
 
<120>  PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES

<130>  23146

<150>  61/791,247
<151>  2013-03-15

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Lactobacillus kefir ketoreductase

<400>  1

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      


Gln Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          


Lys Val Val Ile Thr Gly Arg Arg Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              


Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  


Ser Asp Glu Ala Gly Trp Pro Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  


Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Pro Met Val 
                85                  90                  95      


Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         


Val Asn Leu Asp Gly Val Phe Phe Gly Ala Arg Leu Gly Ile Gln Arg 
        115                 120                 125             


Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Val 
    130                 135                 140                 


Phe Gly Ile Val Gly Asp Pro Thr Thr Gly Ala Tyr Cys Ala Ser Lys 
145                 150                 155                 160 


Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     


Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         


Thr Pro Met Met Asp Ser Tyr Glu Gly Ala Glu Glu Met Phe Ser Gln 
        195                 200                 205             


Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 


Trp Val Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 


Ala Glu Phe Val Val Asp Gly Gly Phe Thr Ala Gln 
                245                 250         


