                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  BIFUNCTIONAL PROTEIN

<130>  X19930

<150>  61/787462
<151>  2013-03-15

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Lys Leu 
            20                  25                  30          


Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ile Ser Phe Gln Gly Gly Thr Tyr Thr Tyr Val Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 
465                 470                 475                 480 


Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr 
                485                 490                 495     


Glu Cys His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Cys Ala Ala 
            500                 505                 510         


Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 
        515                 520                 525             


Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 
    530                 535                 540                 


Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 
545                 550                 555                 560 


Ser Phe Arg Glu Asp Leu Lys Glu Asp Gly Tyr Asn Val Tyr Gln Ser 
                565                 570                 575     


Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asp Lys Ser Pro His 
            580                 585                 590         


Arg Lys Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 
        595                 600                 605             


Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 
    610                 615                 620                 


Pro Asp Val Gly Ser Ser Asp Pro Leu Arg Leu Val Glu Pro Ser Gln 
625                 630                 635                 640 


Leu Arg Ser Pro Ser Phe Glu 
                645         


<210>  2
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 
            20                  25                  30          


Asn Gly Ile Thr Tyr Ser Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Leu Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Tyr Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  3
<211>  1941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cccgttcagt aagctcggca tggtttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gtggtggtta cacatactat      180

ccagacagtg tgaaggggcg gttcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagagaagga      300

attagctttc agggtggcac ctacacttat gttatggact actggggcca gggcaccctg      360

gtcaccgtct cctcagcctc caccaagggc ccatcggtct tcccgctagc gccctgctcc      420

aggagcacct ccgagagcac agccgccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcacga agacctacac ctgcaacgta gatcacaagc ccagcaacac caaggtggac      660

aagagagttg agtccaaata tggtccccca tgcccaccct gcccagcacc tgaggccgcc      720

gggggaccat cagtcttcct gttcccccca aaacccaagg acactctcat gatctcccgg      780

acccctgagg tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc      840

aactggtacg tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

ttcaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac      960

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagag ccacaggtgt acaccctgcc cccatcccag     1080

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     1140

gacatcgccg tggagtggga aagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca ggctaaccgt ggacaagagc     1260

aggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacacaga agagcctctc cctgtctctg ggtggtggtg gtggctccgg aggcggcggc     1380

tctggtggcg gtggcagcgc tcaccccatc cctgactcca gtcctctcct gcaattcggg     1440

ggccaagtcc ggcagcggta cctgtacacc gacgacgccc agcagaccga gtgccacctg     1500

gaaatccggg aggacggcac cgtgggctgt gccgccgacc agtcccctga gtccctgctg     1560

cagctgaagg ccctgaagcc tggcgtgatc cagatcctgg gcgtgaaaac ctcccggttc     1620

ctgtgccaga ggcctgatgg cgccctgtac ggctccctgc acttcgaccc tgaggcctgc     1680

tccttccggg aggacctgaa ggaagatggc tacaacgtgt accagtccga ggctcacggc     1740

ctgcctctgc atctgcctgg cgacaagtcc ccccaccgga agcctgctcc taggggccct     1800

gccagattcc tgccactgcc tggcctgcct ccagctctgc ctgagcctcc tggcatcctg     1860

gcccctcagc ctccagacgt gggctcctcc gaccctctgc ggctggtcga gccttcccag     1920

ctgcggagcc ctagcttcga g                                               1941


<210>  4
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtaa gagtctctta catcgtaatg gcatcactta ttcgtattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atcagctgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgct atcaaaatct agaacttccg      300

ctcacgttcg gccagggcac caaggtggaa atcaaacgga ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgc         657


