                         SEQUENCE LISTING

<110>  Biomet Biologics LLC
 
<120>  Treatment Of Pain Using Protein Solutions

<130>  5490-001017/US

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  1
atggaaatct gcagaggcct ccgcagtcac ctaatcactc tcctcctctt cctgttccat       60

tcagagacga tctgccgacc ctctgggaga aaatccagca agatgcaagc cttcagaatc      120

tgggatgtta accagaagac cttctatctg aggaacaacc aactagttgc tggatacttg      180

caaggaccaa atgtcaattt agaagaaaag atagatgtgg tacccattga gcctcatgct      240

ctgttcttgg gaatccatgg agggaagatg tgcctgtcct gtgtcaagtc tggtgatgag      300

accagactcc agctggaggc agttaacatc actgacctga gcgagaacag aaagcaggac      360

aagcgcttcg ccttcatccg ctcagacagt ggccccacca ccagttttga gtctgccgcc      420

tgccccggtt ggttcctctg cacagcgatg gaagctgacc agcccgtcag cctcaccaat      480

atgcctgacg aaggcgtcat ggtcaccaaa ttctacttcc aggaggacga gtag            534


<210>  2
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  3
<211>  543
<212>  DNA
<213>  Homo sapiens

<400>  3
atggctttag ctgacttgta tgaagaagga ggtggaggag gaggagaagg tgaagacaat       60

gctgactcaa aggagacgat ctgccgaccc tctgggagaa aatccagcaa gatgcaagcc      120

ttcagaatct gggatgttaa ccagaagacc ttctatctga ggaacaacca actagttgct      180

ggatacttgc aaggaccaaa tgtcaattta gaagaaaaga tagatgtggt acccattgag      240

cctcatgctc tgttcttggg aatccatgga gggaagatgt gcctgtcctg tgtcaagtct      300

ggtgatgaga ccagactcca gctggaggca gttaacatca ctgacctgag cgagaacaga      360

aagcaggaca agcgcttcgc cttcatccgc tcagacagtg gccccaccac cagttttgag      420

tctgccgcct gccccggttg gttcctctgc acagcgatgg aagctgacca gcccgtcagc      480

ctcaccaata tgcctgacga aggcgtcatg gtcaccaaat tctacttcca ggaggacgag      540

tag                                                                    543


<210>  4
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Leu Ala Asp Leu Tyr Glu Glu Gly Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Glu Asp Asn Ala Asp Ser Lys Glu Thr Ile Cys Arg Pro Ser Gly 
            20                  25                  30          


Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        35                  40                  45              


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    50                  55                  60                  


Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
65                  70                  75                  80  


Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                85                  90                  95      


Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            100                 105                 110         


Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        115                 120                 125             


Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    130                 135                 140                 


Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
145                 150                 155                 160 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                165                 170                 175     


Gln Glu Asp Glu 
            180 


<210>  5
<211>  480
<212>  DNA
<213>  Homo sapiens

<400>  5
atggctttag agacgatctg ccgaccctct gggagaaaat ccagcaagat gcaagccttc       60

agaatctggg atgttaacca gaagaccttc tatctgagga acaaccaact agttgctgga      120

tacttgcaag gaccaaatgt caatttagaa gaaaagatag atgtggtacc cattgagcct      180

catgctctgt tcttgggaat ccatggaggg aagatgtgcc tgtcctgtgt caagtctggt      240

gatgagacca gactccagct ggaggcagtt aacatcactg acctgagcga gaacagaaag      300

caggacaagc gcttcgcctt catccgctca gacagtggcc ccaccaccag ttttgagtct      360

gccgcctgcc ccggttggtt cctctgcaca gcgatggaag ctgaccagcc cgtcagcctc      420

accaatatgc ctgacgaagg cgtcatggtc accaaattct acttccagga ggacgagtag      480


<210>  6
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  7
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  7
atgcaagcct tcagaatctg ggatgttaac cagaagacct tctatctgag gaacaaccaa       60

ctagttgctg gatacttgca aggaccaaat gtcaatttag aagaaaagat agatgtggta      120

cccattgagc ctcatgctct gttcttggga atccatggag ggaagatgtg cctgtcctgt      180

gtcaagtctg gtgatgagac cagactccag ctggaggcag ttaacatcac tgacctgagc      240

gagaacagaa agcaggacaa gcgcttcgcc ttcatccgct cagacagtgg ccccaccacc      300

agttttgagt ctgccgcctg ccccggttgg ttcctctgca cagcgatgga agctgaccag      360

cccgtcagcc tcaccaatat gcctgacgaa ggcgtcatgg tcaccaaatt ctacttccag      420

gaggacgagt ag                                                          432


<210>  8
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             


<210>  9
<211>  1368
<212>  DNA
<213>  Homo sapiens

<400>  9
atgggcctct ccaccgtgcc tgacctgctg ctgccactgg tgctcctgga gctgttggtg       60

ggaatatacc cctcaggggt tattggactg gtccctcacc taggggacag ggagaagaga      120

gatagtgtgt gtccccaagg aaaatatatc caccctcaaa ataattcgat ttgctgtacc      180

aagtgccaca aaggaaccta cttgtacaat gactgtccag gcccggggca ggatacggac      240

tgcagggagt gtgagagcgg ctccttcacc gcttcagaaa accacctcag acactgcctc      300

agctgctcca aatgccgaaa ggaaatgggt caggtggaga tctcttcttg cacagtggac      360

cgggacaccg tgtgtggctg caggaagaac cagtaccggc attattggag tgaaaacctt      420

ttccagtgct tcaattgcag cctctgcctc aatgggaccg tgcacctctc ctgccaggag      480

aaacagaaca ccgtgtgcac ctgccatgca ggtttctttc taagagaaaa cgagtgtgtc      540

tcctgtagta actgtaagaa aagcctggag tgcacgaagt tgtgcctacc ccagattgag      600

aatgttaagg gcactgagga ctcaggcacc acagtgctgt tgcccctggt cattttcttt      660

ggtctttgcc ttttatccct cctcttcatt ggtttaatgt atcgctacca acggtggaag      720

tccaagctct actccattgt ttgtgggaaa tcgacacctg aaaaagaggg ggagcttgaa      780

ggaactacta ctaagcccct ggccccaaac ccaagcttca gtcccactcc aggcttcacc      840

cccaccctgg gcttcagtcc cgtgcccagt tccaccttca cctccagctc cacctatacc      900

cccggtgact gtcccaactt tgcggctccc cgcagagagg tggcaccacc ctatcagggg      960

gctgacccca tccttgcgac agccctcgcc tccgacccca tccccaaccc ccttcagaag     1020

tgggaggaca gcgcccacaa gccacagagc ctagacactg atgaccccgc gacgctgtac     1080

gccgtggtgg agaacgtgcc cccgttgcgc tggaaggaat tcgtgcggcg cctagggctg     1140

agcgaccacg agatcgatcg gctggagctg cagaacgggc gctgcctgcg cgaggcgcaa     1200

tacagcatgc tggcgacctg gaggcggcgc acgccgcggc gcgaggccac gctggagctg     1260

ctgggacgcg tgctccgcga catggacctg ctgggctgcc tggaggacat cgaggaggcg     1320

ctttgcggcc ccgccgccct cccgcccgcg cccagtcttc tcagatga                  1368


<210>  10
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  11
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcgcccg tcgccgtctg ggccgcgctg gccgtcggac tggagctctg ggctgcggcg       60

cacgccttgc ccgcccaggt ggcatttaca ccctacgccc cggagcccgg gagcacatgc      120

cggctcagag aatactatga ccagacagct cagatgtgct gcagcaaatg ctcgccgggc      180

caacatgcaa aagtcttctg taccaagacc tcggacaccg tgtgtgactc ctgtgaggac      240

agcacataca cccagctctg gaactgggtt cccgagtgct tgagctgtgg ctcccgctgt      300

agctctgacc aggtggaaac tcaagcctgc actcgggaac agaaccgcat ctgcacctgc      360

aggcccggct ggtactgcgc gctgagcaag caggaggggt gccggctgtg cgcgccgctg      420

cgcaagtgcc gcccgggctt cggcgtggcc agaccaggaa ctgaaacatc agacgtggtg      480

tgcaagccct gtgccccggg gacgttctcc aacacgactt catccacgga tatttgcagg      540

ccccaccaga tctgtaacgt ggtggccatc cctgggaatg caagcatgga tgcagtctgc      600

acgtccacgt cccccacccg gagtatggcc ccaggggcag tacacttacc ccagccagtg      660

tccacacgat cccaacacac gcagccaact ccagaaccca gcactgctcc aagcacctcc      720

ttcctgctcc caatgggccc cagcccccca gctgaaggga gcactggcga cttcgctctt      780

ccagttggac tgattgtggg tgtgacagcc ttgggtctac taataatagg agtggtgaac      840

tgtgtcatca tgacccaggt gaaaaagaag cccttgtgcc tgcagagaga agccaaggtg      900

cctcacttgc ctgccgataa ggcccggggt acacagggcc ccgagcagca gcacctgctg      960

atcacagcgc cgagctccag cagcagctcc ctggagagct cggccagtgc gttggacaga     1020

agggcgccca ctcggaacca gccacaggca ccaggcgtgg aggccagtgg ggccggggag     1080

gcccgggcca gcaccgggag ctcagattct tcccctggtg gccatgggac ccaggtcaat     1140

gtcacctgca tcgtgaacgt ctgtagcagc tctgaccaca gctcacagtg ctcctcccaa     1200

gccagctcca caatgggaga cacagattcc agcccctcgg agtccccgaa ggacgagcag     1260

gtccccttct ccaaggagga atgtgccttt cggtcacagc tggagacgcc agagaccctg     1320

ctggggagca ccgaagagaa gcccctgccc cttggagtgc ctgatgctgg gatgaagccc     1380

agttaa                                                                1386


<210>  12
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  13
<211>  1710
<212>  DNA
<213>  Homo sapiens

<400>  13
atgaaagtgt tactcagact tatttgtttc atagctctac tgatttcttc tctggaggct       60

gataaatgca aggaacgtga agaaaaaata attttagtgt catctgcaaa tgaaattgat      120

gttcgtccct gtcctcttaa cccaaatgaa cacaaaggca ctataacttg gtataaagat      180

gacagcaaga cacctgtatc tacagaacaa gcctccagga ttcatcaaca caaagagaaa      240

ctttggtttg ttcctgctaa ggtggaggat tcaggacatt actattgcgt ggtaagaaat      300

tcatcttact gcctcagaat taaaataagt gcaaaatttg tggagaatga gcctaactta      360

tgttataatg cacaagccat atttaagcag aaactacccg ttgcaggaga cggaggactt      420

gtgtgccctt atatggagtt ttttaaaaat gaaaataatg agttacctaa attacagtgg      480

tataaggatt gcaaacctct acttcttgac aatatacact ttagtggagt caaagatagg      540

ctcatcgtga tgaatgtggc tgaaaagcat agagggaact atacttgtca tgcatcctac      600

acatacttgg gcaagcaata tcctattacc cgggtaatag aatttattac tctagaggaa      660

aacaaaccca caaggcctgt gattgtgagc ccagctaatg agacaatgga agtagacttg      720

ggatcccaga tacaattgat ctgtaatgtc accggccagt tgagtgacat tgcttactgg      780

aagtggaatg ggtcagtaat tgatgaagat gacccagtgc taggggaaga ctattacagt      840

gtggaaaatc ctgcaaacaa aagaaggagt accctcatca cagtgcttaa tatatcggaa      900

attgaaagta gattttataa acatccattt acctgttttg ccaagaatac acatggtata      960

gatgcagcat atatccagtt aatatatcca gtcactaatt tccagaagca catgattggt     1020

atatgtgtca cgttgacagt cataattgtg tgttctgttt tcatctataa aatcttcaag     1080

attgacattg tgctttggta cagggattcc tgctatgatt ttctcccaat aaaagcttca     1140

gatggaaaga cctatgacgc atatatactg tatccaaaga ctgttgggga agggtctacc     1200

tctgactgtg atatttttgt gtttaaagtc ttgcctgagg tcttggaaaa acagtgtgga     1260

tataagctgt tcatttatgg aagggatgac tacgttgggg aagacattgt tgaggtcatt     1320

aatgaaaacg taaagaaaag cagaagactg attatcattt tagtcagaga aacatcaggc     1380

ttcagctggc tgggtggttc atctgaagag caaatagcca tgtataatgc tcttgttcag     1440

gatggaatta aagttgtcct gcttgagctg gagaaaatcc aagactatga gaaaatgcca     1500

gaatcgatta aattcattaa gcagaaacat ggggctatcc gctggtcagg ggactttaca     1560

cagggaccac agtctgcaaa gacaaggttc tggaagaatg tcaggtacca catgccagtc     1620

cagcgacggt caccttcatc taaacaccag ttactgtcac cagccactaa ggagaaactg     1680

caaagagagg ctcacgtgcc tctcgggtag                                      1710


<210>  14
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  15
<211>  1197
<212>  DNA
<213>  Homo sapiens

<400>  15
atgttgcgct tgtacgtgtt ggtaatggga gtttctgcct tcacccttca gcctgcggca       60

cacacagggg ctgccagaag ctgccggttt cgtgggaggc attacaagcg ggagttcagg      120

ctggaagggg agcctgtagc cctgaggtgc ccccaggtgc cctactggtt gtgggcctct      180

gtcagccccc gcatcaacct gacatggcat aaaaatgact ctgctaggac ggtcccagga      240

gaagaagaga cacggatgtg ggcccaggac ggtgctctgt ggcttctgcc agccttgcag      300

gaggactctg gcacctacgt ctgcactact agaaatgctt cttactgtga caaaatgtcc      360

attgagctca gagtttttga gaatacagat gctttcctgc cgttcatctc atacccgcaa      420

attttaacct tgtcaacctc tggggtatta gtatgccctg acctgagtga attcacccgt      480

gacaaaactg acgtgaagat tcaatggtac aaggattctc ttcttttgga taaagacaat      540

gagaaatttc taagtgtgag ggggaccact cacttactcg tacacgatgt ggccctggaa      600

gatgctggct attaccgctg tgtcctgaca tttgcccatg aaggccagca atacaacatc      660

actaggagta ttgagctacg catcaagaaa aaaaaagaag agaccattcc tgtgatcatt      720

tcccccctca agaccatatc agcttctctg gggtcaagac tgacaatccc gtgtaaggtg      780

tttctgggaa ccggcacacc cttaaccacc atgctgtggt ggacggccaa tgacacccac      840

atagagagcg cctacccggg aggccgcgtg accgaggggc cacgccagga atattcagaa      900

aataatgaga actacattga agtgccattg atttttgatc ctgtcacaag agaggatttg      960

cacatggatt ttaaatgtgt tgtccataat accctgagtt ttcagacact acgcaccaca     1020

gtcaaggaag cctcctccac gttctcctgg ggcattgtgc tggccccact ttcactggcc     1080

ttcttggttt tggggggaat atggatgcac agacggtgca aacacagaac tggaaaagca     1140

gatggtctga ctgtgctatg gcctcatcat caagactttc aatcctatcc caagtga        1197


<210>  16
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  17
<211>  891
<212>  DNA
<213>  Homo sapiens

<400>  17
atgttgcgct tgtacgtgtt ggtaatggga gtttctgcct tcacccttca gcctgcggca       60

cacacagggg ctgccagaag ctgccggttt cgtgggaggc attacaagcg ggagttcagg      120

ctggaagggg agcctgtagc cctgaggtgc ccccaggtgc cctactggtt gtgggcctct      180

gtcagccccc gcatcaacct gacatggcat aaaaatgact ctgctaggac ggtcccagga      240

gaagaagaga cacggatgtg ggcccaggac ggtgctctgt ggcttctgcc agccttgcag      300

gaggactctg gcacctacgt ctgcactact agaaatgctt cttactgtga caaaatgtcc      360

attgagctca gagtttttga gaatacagat gctttcctgc cgttcatctc atacccgcaa      420

attttaacct tgtcaacctc tggggtatta gtatgccctg acctgagtga attcacccgt      480

gacaaaactg acgtgaagat tcaatggtac aaggattctc ttcttttgga taaagacaat      540

gagaaatttc taagtgtgag ggggaccact cacttactcg tacacgatgt ggccctggaa      600

gatgctggct attaccgctg tgtcctgaca tttgcccatg aaggccagca atacaacatc      660

actaggagta ttgagctacg catcaagaaa aaaaaagaag agaccattcc tgtgatcatt      720

tcccccctca agaccatatc agcttctctg gggtcaagac tgacaatccc gtgtaaggtg      780

tttctgggaa ccggcacacc cttaaccacc atgctgtggt ggacggccaa tgacacccac      840

atagagagcg cctacccggg aggccgcgtg accgaggggc cacgccagta a               891


<210>  18
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln 
    290                 295     


