                         SEQUENCE LISTING



<110>  CollPlant Ltd.

       Gueta, Racheli

       Shoseyov, Oded

       Grynspan Gotlieb, Frida

 

<120>  COMPOSITIONS COMPRISING COLLAGEN AND PRP FOR TISSUE REGENERATION



<130>  57782



<150>  US 61/803,856

<151>  2013-03-21



<160>  5     



<170>  PatentIn version 3.5



<210>  1

<211>  1464

<212>  PRT

<213>  Homo sapiens



<400>  1



Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 

1               5                   10                  15      





Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 

            20                  25                  30          





Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 

        35                  40                  45              





Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 

    50                  55                  60                  





Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 

65                  70                  75                  80  





Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 

                85                  90                  95      





Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 

            100                 105                 110         





Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 

        115                 120                 125             





Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 

    130                 135                 140                 





Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 

145                 150                 155                 160 





Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 

                165                 170                 175     





Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 

            180                 185                 190         





Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 

        195                 200                 205             





Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 

    210                 215                 220                 





Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 

225                 230                 235                 240 





Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 

                245                 250                 255     





Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 

            260                 265                 270         





Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 

        275                 280                 285             





Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 

    290                 295                 300                 





Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 

305                 310                 315                 320 





Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 

                325                 330                 335     





Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 

            340                 345                 350         





Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 

        355                 360                 365             





Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 

    370                 375                 380                 





Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 

385                 390                 395                 400 





Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 

                405                 410                 415     





Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 

            420                 425                 430         





Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 

        435                 440                 445             





Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 

    450                 455                 460                 





Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 

465                 470                 475                 480 





Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 

                485                 490                 495     





Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 

            500                 505                 510         





Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 

        515                 520                 525             





Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 

    530                 535                 540                 





Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 

545                 550                 555                 560 





Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 

                565                 570                 575     





Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 

            580                 585                 590         





Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 

        595                 600                 605             





Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 

    610                 615                 620                 





Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 

625                 630                 635                 640 





Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 

                645                 650                 655     





Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 

            660                 665                 670         





Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 

        675                 680                 685             





Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 

    690                 695                 700                 





Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 

705                 710                 715                 720 





Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 

                725                 730                 735     





Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 

            740                 745                 750         





Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 

        755                 760                 765             





Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 

    770                 775                 780                 





Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 

785                 790                 795                 800 





Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 

                805                 810                 815     





Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 

            820                 825                 830         





Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 

        835                 840                 845             





Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 

    850                 855                 860                 





Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 

865                 870                 875                 880 





Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 

                885                 890                 895     





Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 

            900                 905                 910         





Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 

        915                 920                 925             





Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 

    930                 935                 940                 





Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 

945                 950                 955                 960 





Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 

                965                 970                 975     





Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 

            980                 985                 990         





Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 

        995                 1000                 1005             





Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 

    1010                 1015                 1020             





Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 

    1025                 1030                 1035             





Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 

    1040                 1045                 1050             





Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 

    1055                 1060                 1065             





Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 

    1070                 1075                 1080             





Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 

    1085                 1090                 1095             





Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 

    1100                 1105                 1110             





Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 

    1115                 1120                 1125             





Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 

    1130                 1135                 1140             





Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 

    1145                 1150                 1155             





Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 

    1160                 1165                 1170             





Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 

    1175                 1180                 1185             





Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 

    1190                 1195                 1200             





Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 

    1205                 1210                 1215             





Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 

    1220                 1225                 1230             





Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 

    1235                 1240                 1245             





Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 

    1250                 1255                 1260             





Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 

    1265                 1270                 1275             





Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 

    1280                 1285                 1290             





Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 

    1295                 1300                 1305             





Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 

    1310                 1315                 1320             





Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 

    1325                 1330                 1335             





Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 

    1340                 1345                 1350             





Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 

    1355                 1360                 1365             





His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 

    1370                 1375                 1380             





Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 

    1385                 1390                 1395             





Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 

    1400                 1405                 1410             





Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 

    1415                 1420                 1425             





Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 

    1430                 1435                 1440             





Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 

    1445                 1450                 1455             





Gly Pro  Val Cys Phe Leu 

    1460                 





<210>  2

<211>  1366

<212>  PRT

<213>  Homo sapiens



<400>  2



Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 

1               5                   10                  15      





Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 

            20                  25                  30          





Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 

        35                  40                  45              





Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 

    50                  55                  60                  





Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 

65                  70                  75                  80  





Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 

                85                  90                  95      





Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 

            100                 105                 110         





Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 

        115                 120                 125             





Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 

    130                 135                 140                 





Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 

145                 150                 155                 160 





Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 

                165                 170                 175     





Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 

            180                 185                 190         





Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 

        195                 200                 205             





Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 

    210                 215                 220                 





Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 

225                 230                 235                 240 





Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 

                245                 250                 255     





Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 

            260                 265                 270         





Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 

        275                 280                 285             





Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 

    290                 295                 300                 





Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 

305                 310                 315                 320 





Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 

                325                 330                 335     





Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 

            340                 345                 350         





Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 

        355                 360                 365             





Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 

    370                 375                 380                 





Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 

385                 390                 395                 400 





Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 

                405                 410                 415     





Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 

            420                 425                 430         





Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 

        435                 440                 445             





Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 

    450                 455                 460                 





Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 

465                 470                 475                 480 





Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 

                485                 490                 495     





Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 

            500                 505                 510         





Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 

        515                 520                 525             





Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 

    530                 535                 540                 





Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 

545                 550                 555                 560 





Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 

                565                 570                 575     





Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 

            580                 585                 590         





Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 

        595                 600                 605             





Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 

    610                 615                 620                 





Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 

625                 630                 635                 640 





Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 

                645                 650                 655     





Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 

            660                 665                 670         





Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 

        675                 680                 685             





Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 

    690                 695                 700                 





Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 

705                 710                 715                 720 





Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 

                725                 730                 735     





Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 

            740                 745                 750         





Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 

        755                 760                 765             





Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 

    770                 775                 780                 





Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 

785                 790                 795                 800 





Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 

                805                 810                 815     





Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 

            820                 825                 830         





Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 

        835                 840                 845             





Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 

    850                 855                 860                 





Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 

865                 870                 875                 880 





Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 

                885                 890                 895     





Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 

            900                 905                 910         





Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 

        915                 920                 925             





Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 

    930                 935                 940                 





Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 

945                 950                 955                 960 





Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 

                965                 970                 975     





Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 

            980                 985                 990         





Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 

        995                 1000                 1005             





Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 

    1010                 1015                 1020             





Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 

    1025                 1030                 1035             





Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 

    1040                 1045                 1050             





Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 

    1055                 1060                 1065             





Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 

    1070                 1075                 1080             





Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 

    1085                 1090                 1095             





Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 

    1100                 1105                 1110             





Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 

    1115                 1120                 1125             





Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 

    1130                 1135                 1140             





Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 

    1145                 1150                 1155             





Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 

    1160                 1165                 1170             





Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 

    1175                 1180                 1185             





Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 

    1190                 1195                 1200             





Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 

    1205                 1210                 1215             





Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 

    1220                 1225                 1230             





Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 

    1235                 1240                 1245             





Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 

    1250                 1255                 1260             





Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 

    1265                 1270                 1275             





Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 

    1280                 1285                 1290             





Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 

    1295                 1300                 1305             





Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 

    1310                 1315                 1320             





Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 

    1325                 1330                 1335             





Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 

    1340                 1345                 1350             





Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 

    1355                 1360                 1365     





<210>  3

<211>  1633

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Synthetic sequence containing the coding regions of the vascular 

       signal sequence of barley gene for Thiol protease aleurain 

       precursor fused to the human Prolyl 4-hydroxylase beta subunit 

       and flanking regions



<400>  3

ctcgagtaaa ccatggctca tgctagggtt ttgcttttgg ctcttgctgt tcttgctact       60



gctgctgttg ctgtggcttc ttcttcatct ttcgctgatt ctaacccaat taggccagtg      120



actgatagag ctgcttctac tcttgctcaa ttggtcgaca tggatgctcc agaagaggag      180



gatcacgttc ttgtgcttag gaagtctaac ttcgctgaag ctcttgctgc tcacaagtac      240



cttcttgtgg agttttatgc tccttggtgc ggacattgca aagctcttgc tccagagtat      300



gctaaggctg ctggaaagtt gaaggctgag ggatctgaaa ttaggcttgc taaagtggat      360



gctactgagg agtctgatct tgctcaacag tacggagtta ggggataccc aactattaag      420



ttcttcagga acggagatac tgcttctcca aaggagtata ctgctggaag ggaggctgat      480



gatattgtga actggcttaa gaagagaact ggaccagctg ctactactct tccagatgga      540



gctgctgctg aatctcttgt ggagtcatct gaggtggcag tgattggatt cttcaaggat      600



gtggagtctg attctgctaa gcagttcctt caagctgctg aggctattga tgatattcca      660



ttcggaatta cttctaactc tgatgtgttc tctaagtacc agcttgataa ggatggagtg      720



gtgcttttca agaaattcga tgagggaagg aacaatttcg agggagaggt gacaaaggag      780



aaccttcttg atttcattaa gcacaaccag cttccacttg tgattgagtt cactgagcag      840



actgctccaa agattttcgg aggagagatt aagactcaca ttcttctttt ccttccaaag      900



tctgtgtctg attacgatgg aaagttgtct aacttcaaga ctgctgctga gtctttcaag      960



ggaaagattc ttttcatttt cattgattct gatcacactg ataaccagag gattcttgag     1020



ttcttcggac ttaagaagga agagtgccca gctgttaggc ttattactct tgaggaggag     1080



atgactaagt acaagccaga gtctgaagaa cttactgctg agaggattac tgagttctgc     1140



cacagattcc ttgagggaaa gattaagcca caccttatgt ctcaagagct tccagaggat     1200



tgggataagc agccagttaa ggtgttggtg ggtaaaaact tcgaggatgt ggctttcgat     1260



gagaagaaga acgtgttcgt ggagttctac gcaccttggt gtggtcactg taagcagctt     1320



gctccaattt gggataagtt gggagagact tacaaggatc acgagaacat tgtgattgct     1380



aagatggatt ctactgctaa cgaggtggag gctgttaagg ttcactcttt cccaactttg     1440



aagttcttcc cagcttctgc tgataggact gtgattgatt acaacggaga aaggactctt     1500



gatggattca agaagttcct tgagtctgga ggacaagatg gagctggaga tgatgatgat     1560



cttgaggatt tggaagaagc tgaggagcca gatatggagg aggatgatga tcagaaggct     1620



gtgtgatgag ctc                                                        1633





<210>  4

<211>  1723

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Synthetic sequence containing the coding regions of the vascular 

       signal sequence of barley gene for Thiol protease aleurain 

       precursor fused to the human Prolyl 4-hydroxylase alpha-1 subunit

       and flanking regions



<400>  4

ctcgagtaaa ccatggctca tgctagggtt ttgcttttgg ctcttgctgt tcttgctact       60



gctgctgttg ctgtggcttc ttcttcatct ttcgctgatt ctaacccaat taggccagtg      120



actgatagag ctgcttctac tcttgctcaa ttggtcgaca tgcacccagg attcttcact      180



tctattggac agatgactga tcttattcac actgagaagg atcttgtgac ttctcttaag      240



gattacatta aggctgagga ggataagttg gagcagatta agaagtgggc tgagaagttg      300



gataggctta cttctactgc tacaaaagat ccagagggat tcgttggtca tccagtgaac      360



gctttcaagt tgatgaagag gcttaacact gagtggagtg agcttgagaa ccttgtgctt      420



aaggatatgt ctgatggatt catttctaac cttactattc agaggcagta cttcccaaat      480



gatgaggatc aagtgggagc tgctaaggct cttcttaggc ttcaggatac ttacaacctt      540



gatactgata caatttctaa gggaaacctt ccaggagtta agcacaagtc tttccttact      600



gctgaggatt gcttcgagct tggaaaggtt gcatacactg aggctgatta ctaccacact      660



gagctttgga tggaacaagc tcttaggcaa cttgatgagg gagagatttc tactattgat      720



aaggtgtcag tgcttgatta cctttcttac gctgtgtacc agcagggtga tcttgataag      780



gctcttttgc ttactaagaa gttgcttgag cttgatccag aacatcagag ggctaacgga      840



aaccttaagt acttcgagta cattatggct aaggaaaagg atgtgaacaa gtctgcttct      900



gatgatcagt ctgatcaaaa gactactcca aagaagaagg gagtggctgt tgattatctt      960



cctgagaggc agaagtatga gatgttgtgt aggggagagg gtattaagat gactccaagg     1020



aggcagaaga agttgttctg caggtatcac gatggaaaca ggaacccaaa gttcattctt     1080



gctccagcta agcaagaaga tgagtgggat aagccaagga ttattaggtt ccacgatatt     1140



atttctgatg ctgagattga gattgtgaag gatcttgcta agccaagact taggagggct     1200



actatttcta accctattac tggtgatctt gagactgtgc actacaggat ttctaagtct     1260



gcttggcttt ctggatacga gaacccagtg gtgtctagga ttaacatgag gattcaggat     1320



cttactggac ttgatgtgtc tactgctgag gagcttcaag ttgctaacta cggagttgga     1380



ggacaatatg agccacactt cgatttcgct aggaaggatg agccagatgc ttttaaggag     1440



cttggaactg gaaacaggat tgctacttgg cttttctaca tgtctgatgt ttctgctgga     1500



ggagctactg ttttcccaga agtgggagct tctgtttggc caaagaaggg aactgctgtg     1560



ttctggtaca accttttcgc ttctggagag ggagattact ctactaggca tgctgcttgc     1620



ccagttcttg ttggaaacaa gtgggtgtca aacaagtggc ttcatgagag gggacaagag     1680



tttagaaggc catgcactct ttctgagctt gagtgatgag ctc                       1723





<210>  5

<211>  2888

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Synthetic sequence containing the coding regions of the vascular 

       signal sequence of barley gene for Thiol protease aleurain 

       precursor fused to the human Lysyl hydroxylase 3 and flanking 

       regions



<400>  5

gcgaattcgc tagctatcac tgaaaagaca gcaagacaat ggtgtctcga tgcaccagaa       60



ccacatcttt gcagcagatg tgaagcagcc agagtggtcc acaagacgca ctcagaaaag      120



gcatcttcta ccgacacaga aaaagacaac cacagctcat catccaacat gtagactgtc      180



gttatgcgtc ggctgaagat aagactgacc ccaggccagc actaaagaag aaataatgca      240



agtggtccta gctccacttt agctttaata attatgtttc attattattc tctgcttttg      300



ctctctatat aaagagcttg tattttcatt tgaaggcaga ggcgaacaca cacacagaac      360



ctccctgctt acaaaccaga tcttaaacca tggctcacgc tagggttttg cttcttgctc      420



ttgctgttct tgctactgct gctgttgctg tggcttcttc aagttctttc gctgattcta      480



acccaattag gccagtgact gatagagctg cttctactct tgctcaattg agatctatgt      540



ctgatagacc aaggggaagg gatccagtta atccagagaa gttgcttgtg attactgtgg      600



ctactgctga gactgaagga taccttagat tccttaggag tgctgagttc ttcaactaca      660



ctgtgaggac tcttggactt ggagaagaat ggaggggagg agatgttgct agaactgttg      720



gaggaggaca gaaagtgaga tggcttaaga aagagatgga gaagtacgct gatagggagg      780



atatgattat tatgttcgtg gattcttacg atgtgattct tgctggatct ccaactgagc      840



ttttgaagaa attcgttcag tctggatcta ggcttctttt ctctgctgag tctttttgtt      900



ggccagaatg gggacttgct gagcaatatc cagaagtggg aactggaaag agattcctta      960



actctggagg attcattgga ttcgctacta ctattcacca gattgtgagg cagtggaagt     1020



acaaggatga cgatgatgat cagcttttct acactaggct ttaccttgat ccaggactta     1080



gggagaagtt gtctcttaac cttgatcaca agtctaggat tttccagaac cttaacggtg     1140



ctcttgatga ggttgtgctt aagttcgata ggaacagagt gaggattagg aacgtggctt     1200



acgatactct tcctattgtg gtgcatggaa acggaccaac aaaactccag cttaactacc     1260



ttggaaacta cgttccaaac ggatggactc cagaaggagg atgtggattc tgcaatcagg     1320



ataggagaac tcttccagga ggacaaccac caccaagagt tttccttgct gtgttcgttg     1380



aacagccaac tccattcctt ccaagattcc ttcagaggct tcttcttttg gattacccac     1440



cagatagggt gacacttttc cttcacaaca acgaggtttt ccacgagcca cacattgctg     1500



attcttggcc acagcttcag gatcatttct ctgctgtgaa gttggttggt ccagaagaag     1560



ctctttctcc aggagaagct agggatatgg ctatggattt gtgcaggcag gatccagagt     1620



gcgagttcta cttctctctt gatgctgatg ctgtgcttac taaccttcag actcttagga     1680



ttcttattga ggagaacagg aaagtgattg ctccaatgct ttctaggcac ggaaagttgt     1740



ggtctaattt ctggggtgct ctttctcctg atgagtacta cgctagatca gaggactacg     1800



tggagcttgt tcagagaaag agagtgggag tttggaacgt tccttatatt tctcaggctt     1860



acgtgattag gggagatact cttaggatgg agcttccaca gagggatgtt ttctctggat     1920



ctgatactga tccagatatg gctttctgca agtctttcag ggataaggga attttccttc     1980



acctttctaa ccagcatgag ttcggaagat tgcttgctac ttcaagatac gatactgagc     2040



accttcatcc tgatctttgg cagattttcg ataacccagt ggattggaag gagcagtaca     2100



ttcacgagaa ctactctagg gctcttgaag gagaaggaat tgtggagcaa ccatgcccag     2160



atgtttactg gttcccactt ctttctgagc aaatgtgcga tgagcttgtt gctgagatgg     2220



agcattacgg acaatggagt ggaggtagac atgaggattc taggcttgct ggaggatacg     2280



agaacgttcc aactgtggat attcacatga agcaagtggg atacgaggat caatggcttc     2340



agcttcttag gacttatgtg ggaccaatga ctgagtctct tttcccagga taccacacta     2400



aggctagggc tgttatgaac ttcgttgtga ggtatcgtcc agatgagcaa ccatctctta     2460



ggccacacca cgattcttct actttcactc ttaacgtggc tcttaaccac aagggacttg     2520



attatgaggg aggaggatgc cgtttcctta gatacgattg cgtgatttct tcaccaagaa     2580



agggatgggc tcttcttcat ccaggaaggc ttactcatta ccacgaggga cttccaacta     2640



cttggggaac tagatatatt atggtgtctt tcgtggatcc atgactgctt taatgagata     2700



tgcgagacgc ctatgatcgc atgatatttg ctttcaattc tgttgtgcac gttgtaaaaa     2760



acctgagcat gtgtagctca gatccttacc gccggtttcg gttcattcta atgaatatat     2820



cacccgttac tatcgtattt ttatgaataa tattctccgt tcaatttact gattgtccag     2880



aattcgcg                                                              2888





