                         SEQUENCE LISTING

<110>  Profactor Pharma Ltd
 
<120>  Recombinant Protein

<130>  PE955669WO

<150>  GB1304973.9
<151>  2013-03-19

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  4377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimised B domain deleted F VIII sequence for expression 
       in CHO cells

<400>  1
atgcagatcg agctgtccac ctgctttttt ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggag ctgtcctggg actacatgca gagcgacctg      120

ggcgagctgc ctgtggacgc ccggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gccagccacc ccgtgagcct gcacgccgtg      360

ggcgtgagct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgg      420

gagaaagaag atgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaacagcggc ctgatcggcg ctctgctcgt ctgccgggag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcccaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggcc tgattggctg ccaccggaag agcgtgtact ggcacgtgat cggcatgggc      840

accacacccg aggtgcacag catctttctg gaagggcaca cctttctggt ccggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagctctc accagcacga cggcatggaa     1020

gcctacgtga aggtggactc ttgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcggttcgac     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccccct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac ccgggaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacacactg     1440

ctgatcatct tcaagaacca ggctagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag caggcggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga ggacggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggacctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaacatc cagcggtttc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgactctc tgcagctctc cgtgtgtctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggacaccct gaccctgttc cctttcagcg gcgagacagt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg tccaagaaca acgccatcga accccggagc     2280

ttcagccaga acccccccgt gctgaagcgt caccagcggg agatcacccg gacaaccctg     2340

cagtccgacc aggaagagat cgattacgac gacaccatca gcgtggagat gaagaaagag     2400

gatttcgata tctacgacga ggacgagaac cagagcccca gaagcttcca gaagaaaacc     2460

cggcactact tcattgccgc cgtggagagg ctgtgggact acggcatgag ttctagcccc     2520

cacgtgctgc ggaaccgggc ccagagcggc agcgtgcccc agttcaagaa agtggtgttc     2580

caggaattca cagacggcag cttcacccag cctctgtata gaggcgagct gaacgagcac     2640

ctggggctgc tggggcccta catcagggcc gaagtggagg acaacatcat ggtgaccttc     2700

cggaatcagg ccagcagacc ctactccttc tacagcagcc tgatcagcta cgaagaggac     2760

cagcggcagg gcgccgaacc ccggaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg     2880

gcctacttca gcgacgtgga tctggaaaag gacgtgcact ctggactgat tggcccactc     2940

ctggtctgcc acactaacac cctcaacccc gcccacggcc gccaggtgac cgtgcaggaa     3000

ttcgccctgt tcttcaccat cttcgacgag acaaagtcct ggtacttcac cgagaatatg     3060

gaacggaact gcagagcccc ctgcaacatc cagatggaag atcctacctt caaagagaac     3120

taccggttcc acgccatcaa cggctacatc atggacaccc tgcctggcct ggtgatggcc     3180

caggaccaga gaatccggtg gtatctgctg tccatgggca gcaacgagaa tatccacagc     3240

atccacttca gcggccacgt gttcaccgtg cggaagaaag aagagtacaa gatggccctg     3300

tacaacctgt accccggcgt gttcgagaca gtggagatgc tgcccagcaa ggccggcatc     3360

tggcgggtgg agtgtctgat cggcgagcac ctgcacgctg gcatgagcac cctgtttctg     3420

gtgtacagca acaagtgcca gaccccactg ggcatggcct ctggccacat ccgggacttc     3480

cagatcaccg cctccggcca gtacggccag tgggccccca agctggccag actgcactac     3540

agcggcagca tcaacgcctg gtccaccaaa gagcccttca gctggatcaa ggtggacctg     3600

ctggccccta tgatcatcca cggcattaag acccagggcg ccaggcagaa gttcagcagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

cggggcaaca gcaccggcac cctgatggtg ttcttcggca atgtggacag cagcggcatc     3780

aagcacaaca tcttcaaccc ccccatcatt gcccggtaca tccggctgca ccccacccac     3840

tacagcatta gatccacact gagaatggaa ctgatgggct gcgacctgaa ctcctgcagc     3900

atgcctctgg gcatggaaag caaggccatc agcgacgccc agatcacagc cagcagctac     3960

ttcaccaaca tgttcgccac ctggtccccc tccaaggcca ggctgcacct gcagggccgg     4020

tccaacgcct ggcggcctca ggtcaacaac cccaaagaat ggctgcaggt ggactttcag     4080

aaaaccatga aggtgaccgg cgtgaccacc cagggcgtga aaagcctgct gaccagcatg     4140

tacgtgaaag agtttctgat cagcagctct caggatggcc accagtggac cctgttcttt     4200

cagaacggca aggtgaaagt gttccagggc aaccaggact ccttcacccc cgtggtgaac     4260

tccctggacc cccccctgct gacccgctac ctgagaatcc acccccagtc ttgggtgcac     4320

cagatcgccc tcaggatgga agtcctggga tgtgaggccc aggatctgta ctgatga        4377


<210>  2
<211>  8445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimised VWF sequence for CHO expression

<400>  2
atgatccctg ccagatttgc cggcgtgctg ctggccctgg ctctgatcct gcctggcaca       60

ctgtgtgccg agggcaccag aggcagatcc tctaccgccc ggtgttccct gttcggctcc      120

gacttcgtga acaccttcga cggctccatg tacagcttcg ccggctactg ctcctacctg      180

ctggctggcg gctgccagaa gcggtccttc tctatcatcg gcgacttcca gaacggcaag      240

cgggtgtccc tgtccgtgta cctgggcgag ttcttcgaca tccacctgtt cgtgaacggc      300

accgtgaccc agggcgatca gagggtgtcc atgccctacg cctccaaggg cctgtacctg      360

gaaaccgagg ccggctacta caagctgtcc ggcgaggcct acggcttcgt ggccagaatc      420

gatggctccg gcaacttcca ggtgctgctg tccgaccggt acttcaacaa gacctgcggc      480

ctgtgcggca acttcaacat cttcgccgag gacgacttca tgacccagga aggcaccctg      540

acctccgacc cctacgactt cgccaactcc tgggctctgt cctccggcga gcagtggtgc      600

gagagagcca gccctccttc ctcctcctgc aacatctcca gcggcgagat gcagaaaggc      660

ctgtgggagc agtgccagct gctgaagtcc acctctgtgt tcgcccggtg ccaccctctg      720

gtggaccctg agccttttgt ggccctgtgc gaaaagaccc tgtgcgagtg tgctggcggc      780

ctggaatgtg cctgtcctgc cctgctggaa tacgccagaa cctgcgctca ggaaggcatg      840

gtcctgtacg gctggaccga ccactctgcc tgctctccag tgtgtcctgc cggcatggaa      900

taccggcagt gcgtgtcccc ttgcgccagg acctgtcagt ccctgcacat caacgagatg      960

tgccaggaac gctgcgtgga cggctgctct tgtcctgagg gacagctgct ggacgagggc     1020

ctgtgcgtgg aatctaccga gtgcccttgc gtgcactccg gcaagagata ccctcctggc     1080

acctccctgt cccgggactg caacacctgt atctgccgga actcccagtg gatctgctcc     1140

aacgaggaat gccctggcga gtgcctggtc accggccagt cccacttcaa gtccttcgac     1200

aacagatact tcaccttctc cggcatctgc cagtatctgc tggccagaga ctgccaggac     1260

cactccttct ccatcgtgat cgaaaccgtg cagtgcgccg acgacagaga tgccgtgtgc     1320

accagatctg tgaccgtgcg gctgcctggc ctgcacaact ctctggtcaa gctgaagcac     1380

ggcgctggcg tggccatgga tggacaggat gtgcagctgc ccctgctgaa gggcgacctg     1440

agaatccagc acaccgtgac cgcaagcgtg cggctgtctt acggcgagga cctgcagatg     1500

gactgggacg gcagaggcag actgctggtc aaactgtccc ctgtgtacgc cggcaagacc     1560

tgtggactgt gtggaaacta caacggcaac cagggcgacg atttcctgac cccttctggc     1620

ctggccgagc cccgggtgga agattttggc aacgcctgga agctgcacgg cgactgtcag     1680

gatctgcaga agcagcactc cgacccttgc gccctgaacc cccggatgac ccggttttct     1740

gaagaggcct gtgccgtgct gacctcccct acctttgagg cctgtcacag agccgtgtcc     1800

cccctgccct acctgcggaa ctgtagatac gacgtgtgct cctgctccga cggccgcgaa     1860

tgtctgtgtg gcgccctggc ttcttacgcc gctgcttgtg ctggcagagg cgtcagagtg     1920

gcttggcggg aacctggcag atgcgagctg aactgcccta agggccaggt gtacctgcag     1980

tgcggcaccc cttgcaacct gacctgtcgg agcctgtcct accccgacga agagtgcaac     2040

gaggcctgcc tggaaggctg cttctgtccc cctggcctgt acatggacga gaggggcgac     2100

tgtgtgccca aggcccagtg cccctgttac tacgacggcg agatcttcca gcccgaggac     2160

atcttctccg accaccacac catgtgctac tgcgaggatg gcttcatgca ctgcaccatg     2220

tctggcgtgc ccggctctct gctgcctgat gctgtgctgt ccagccctct gtcccaccgg     2280

tccaagagat ccctgtcttg ccggcctccc atggtcaagc tggtctgccc tgccgacaac     2340

ctgagagccg agggactgga atgcaccaag acctgccaga actacgacct ggaatgcatg     2400

tccatgggct gcgtgtccgg ctgcctgtgt ccacctggaa tggtccgaca cgagaacaga     2460

tgcgtggccc tggaacggtg cccatgcttt catcagggca aagagtacgc ccctggcgag     2520

acagtgaaga tcggctgcaa tacctgcgtg tgccgggacc ggaagtggaa ctgcaccgat     2580

cacgtgtgcg acgccacctg ttccacaatc ggcatggccc actacctgac cttcgatggc     2640

ctgaagtacc tgttccccgg cgagtgccag tacgtgctgg tgcaggacta ctgcggctcc     2700

aaccccggca ccttcagaat cctggtcgga aacaagggct gctcccaccc ctccgtgaag     2760

tgcaagaagc gggtcaccat cctggtcgag ggcggcgaga tcgagctgtt cgacggcgaa     2820

gtgaacgtga agcggcccat gaaggacgag acacacttcg aggtggtgga atccggccgg     2880

tacatcatcc tgctgctggg caaggccctg tccgtcgtgt gggacagaca cctgagcatc     2940

tccgtggtgc tgaagcagac ctaccaggaa aaagtctgcg ggctgtgtgg caatttcgac     3000

ggcatccaga acaacgatct gacctccagc aacctgcagg tcgaagagga ccccgtggac     3060

ttcggcaaca gctggaaggt gtcctcccag tgtgccgaca ccagaaaggt gcccctggac     3120

tcctctcccg ccacctgtca caacaacatc atgaagcaga caatggtgga ctcctcctgt     3180

agaatcctga ccagcgacgt gttccaggac tgtaacaagc tggtcgatcc cgagccctac     3240

ctggacgtgt gtatctacga tacctgctcc tgcgagtcta tcggcgactg cgcctgcttc     3300

tgcgacacaa tcgccgccta cgcccacgtg tgcgctcagc atggaaaggt ggtcacctgg     3360

cggaccgcca ccctgtgtcc tcagtcctgc gaggaacgga acctgcgcga gaacggctac     3420

gagtgcgagt ggcggtacaa ctcttgcgcc cctgcctgcc aggtcacatg ccagcatcct     3480

gagcctctgg cctgccctgt gcagtgcgtg gaaggctgtc acgcccattg tcctcccggc     3540

aagatcctgg acgagctgct gcagacctgt gtggaccccg aggactgtcc tgtgtgcgaa     3600

gtggccggca gaagattcgc cagcggcaag aaagtgaccc tgaacccttc cgaccccgag     3660

cactgccaga tctgccactg cgacgtggtc aatctgacct gcgaggcttg ccaggaacca     3720

ggcggactgg tcgtgcctcc taccgatgct cctgtgtccc ccaccaccct gtacgtcgag     3780

gacatcagcg agccccccct gcacgacttc tactgctcta ggctgctgga cctggtgttc     3840

ctgctggacg gctcctccag actgtccgag gccgagttcg aggtgctgaa ggccttcgtg     3900

gtggacatga tggaacggct gcggatctcc cagaaatggg tccgagtggc cgtggtggaa     3960

taccacgatg gctcccacgc ctacatcggc ctgaaggaca gaaagcggcc ttccgagctg     4020

cggcggatcg ccagccaggt caaatacgct ggaagccagg tggcctccac ctccgaagtg     4080

ctgaagtata ccctgttcca gatcttctcc aagatcgacc ggcccgaggc ctccagaatc     4140

acactgctgc tgatggcctc ccaggaaccc cagcggatgt cccggaactt cgtcagatac     4200

gtgcagggcc tgaagaaaaa gaaagtgatc gtgatccccg tgggcatcgg cccccacgcc     4260

aatctgaagc agatccggct gatcgagaag caggcccccg agaacaaggc ctttgtgctg     4320

tcctccgtgg atgagctgga acagcagcgg gacgagatcg tgtcctacct gtgcgatctg     4380

gcccctgagg ctcctcctcc taccctgcct cctgatatgg cccaggtcac agtgggacct     4440

ggcctgctgg gagtgtctac cctgggaccc aagcggaaca gcatggtgct ggacgtggca     4500

ttcgtgctgg aaggctccga caagatcggc gaggccgact tcaaccggtc caaagagttc     4560

atggaagagg tcatccagcg gatggacgtg ggccaggact ccatccacgt gaccgtgctg     4620

cagtactcct acatggtcac cgtggaatac cccttcagcg aggcccagtc caagggcgac     4680

atcctgcaga gagtgcgcga gatcagatac cagggcggca acaggaccaa caccggcctg     4740

gcactgagat acctgtccga ccacagtttt ctggtgtctc agggcgacag agagcaggcc     4800

cctaacctgg tgtatatggt caccggaaac cccgcctccg acgagatcaa gagactgccc     4860

ggcgacatcc aggtggtgcc tatcggcgtg ggacccaacg ccaacgtgca ggaactggaa     4920

cggatcggct ggcccaacgc ccccatcctg atccaggact tcgagacact gccccgcgag     4980

gcccctgatc tggtgctgca gagatgctgt agcggcgagg ggctgcagat ccctaccctg     5040

tctccagccc ctgactgctc ccagcctctg gacgtgatcc tgctgctgga cggcagctct     5100

agcttccccg cctcctactt cgacgagatg aagtccttcg ccaaggcctt catctccaag     5160

gccaacatcg gccctcggct gacccaggtg tccgtcctgc agtacggctc catcaccacc     5220

atcgacgtgc catggaacgt ggtgcccgag aaggcccatc tgctgtccct ggtggacgtg     5280

atgcagagag agggcggacc ttcccagatc ggagatgccc tgggcttcgc cgtgcggtat     5340

ctgacctctg agatgcacgg cgccagacct ggcgcctcta aggctgtggt catcctggtc     5400

acagacgtgt ccgtggacag cgtggacgct gccgctgatg ccgccagatc caacagagtg     5460

accgtgttcc ctatcggcat cggcgacaga tacgacgccg cccagctgag aatcctggct     5520

ggacctgccg gcgactccaa cgtcgtgaag ctgcagagaa tcgaggatct gcccaccatg     5580

gtgaccctgg gcaacagctt cctgcacaag ctgtgctccg gcttcgtgcg gatctgcatg     5640

gacgaggacg gcaacgagaa gcggcctggc gacgtgtgga cactgcctga tcagtgccat     5700

accgtgacct gccagcctga cggccagacc ctgctgaaat cccacagagt gaactgcgac     5760

cggggcctga ggccttcctg ccctaactct cagtcccccg tgaaggtgga agagacatgc     5820

ggctgccggt ggacctgccc ttgtgtgtgt accggctcct ctacccggca catcgtgacc     5880

tttgacggac agaacttcaa gctgaccggc tcctgtagct acgtgctgtt ccagaacaaa     5940

gaacaggacc tggaagtgat tctgcacaac ggcgcctgct ccccaggcgc tagacagggc     6000

tgcatgaagt ctatcgaagt gaagcactcc gccctgagcg tcgagctgca ctccgacatg     6060

gaagtgaccg tgaatggccg gctggtgtcc gtgccttacg tgggcggcaa tatggaagtg     6120

aatgtgtacg gcgccatcat gcacgaagtg cggttcaacc acctgggcca catcttcacc     6180

ttcacacctc agaacaatga gttccagctg cagctgtccc ccaagacctt cgcctccaag     6240

acatacggcc tgtgtggaat ctgtgacgag aacggcgcca acgatttcat gctgcgggac     6300

ggaaccgtga ccaccgactg gaaaaccctg gtccaggaat ggaccgtcca gcgcccagga     6360

cagacctgtc agcccatcct ggaagaacag tgcctggtgc ccgactccag ccactgtcag     6420

gtcctgctgc tgcctctgtt cgccgagtgc cacaaggtgc tggcccctgc caccttctac     6480

gctatctgtc agcaggacag ctgccaccag gaacaggtct gcgaagtcat tgccagctac     6540

gctcacctgt gccggaccaa cggcgtgtgt gtggattggc ggacccctga cttctgcgcc     6600

atgtcctgtc ccccttccct ggtgtacaac cactgcgagc acggctgccc cagacactgt     6660

gatggcaacg tgtcctcctg cggcgaccac ccttctgagg gctgtttctg ccctcctgac     6720

aaagtgatgc tggaaggatc ttgcgtgccc gaagaggctt gcacccagtg catcggagag     6780

gatggcgtgc agcaccagtt tctggaagcc tgggtgccag accaccagcc ttgtcagatc     6840

tgcacctgtc tgtccggccg gaaagtgaac tgtaccaccc agccttgccc caccgccaag     6900

gctcctacat gtggcctgtg tgaagtggcc cggctgagac agaacgccga ccagtgctgt     6960

cccgagtacg agtgcgtgtg cgaccccgtg tcttgcgatc tgcctcctgt gccccattgc     7020

gagagaggcc tgcagcctac cctgaccaac ccaggcgagt gccggcccaa ctttacctgc     7080

gcctgccgga aagaggaatg caagagagtc agccccccca gctgcccccc tcatagactg     7140

ccaaccctga gaaagaccca gtgctgtgat gagtatgagt gcgcctgcaa ctgcgtgaac     7200

tccaccgtgt cctgtcctct gggctacctg gccagcaccg ccaccaacga ttgtggctgc     7260

accaccacca cctgtctgcc cgacaaagtg tgcgtgcacc ggtccaccat ctaccccgtg     7320

ggccagtttt gggaagaggg ctgcgacgtg tgtacctgta ccgatatgga agatgccgtg     7380

atgggcctgc gggtggccca gtgttctcag aagccttgcg aggactcttg cagatctggc     7440

ttcacctacg tgctgcacga gggcgagtgc tgcggcagat gtctgccttc tgcttgcgag     7500

gtcgtgaccg gctctcctag aggcgactcc cagtcctcct ggaagtccgt gggatctcag     7560

tgggcctccc ctgagaaccc ttgcctgatc aacgagtgtg tgcgcgtgaa agaagaggtg     7620

ttcatccagc agcggaacgt gtcctgcccc cagctggaag tccctgtgtg cccttccggc     7680

ttccagctga gttgcaagac ctccgcctgc tgcccttcct gtagatgcga gcggatggaa     7740

gcctgcatgc tgaatggcac agtgatcggc cctggcaaga ccgtgatgat tgacgtgtgc     7800

acaacctgcc ggtgcatggt gcaggtcgga gtgatcagcg gcttcaagct ggaatgcaga     7860

aagaccacct gtaacccctg ccccctgggc tacaaagaag agaacaacac cggcgagtgt     7920

tgtggccggt gcctgcctac cgcttgcacc attcagctga gaggcggcca gatcatgacc     7980

ctgaagcggg acgaaaccct gcaggacggc tgcgataccc acttctgcaa agtgaacgag     8040

cggggcgagt acttctggga gaagagagtg accggctgcc ccccattcga cgagcacaag     8100

tgtctggctg agggcggaaa gattatgaag atccctggca cctgttgcga cacatgcgag     8160

gaacccgagt gtaacgacat caccgccaga ctgcagtacg tgaaagtggg ctcctgcaag     8220

tccgaggtgg aagtggacat ccactactgc cagggcaagt gcgccagcaa ggccatgtac     8280

tccatcgaca tcaacgacgt gcaggaccag tgctcttgct gctcccccac cagaaccgag     8340

cctatgcagg tcgccctgca ctgtaccaac ggctccgtgg tgtaccacga ggtcctgaac     8400

gccatggaat gcaagtgctc cccccggaag tgctccaagt gatga                     8445


<210>  3
<211>  1457
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             


Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 
    770                 775                 780                 


Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 
785                 790                 795                 800 


Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 
                805                 810                 815     


Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 
            820                 825                 830         


Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 
        835                 840                 845             


Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 
    850                 855                 860                 


Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 
865                 870                 875                 880 


Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 
                885                 890                 895     


Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
            900                 905                 910         


Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 
        915                 920                 925             


Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 
    930                 935                 940                 


Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 
945                 950                 955                 960 


Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 
                965                 970                 975     


Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 
            980                 985                 990         


Gly Arg Gln Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
        995                 1000                 1005             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1010                 1015                 1020             


Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 
    1040                 1045                 1050             


Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1055                 1060                 1065             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1070                 1075                 1080             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    1085                 1090                 1095             


Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    1100                 1105                 1110             


Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 
    1115                 1120                 1125             


Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    1130                 1135                 1140             


Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 
    1145                 1150                 1155             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    1160                 1165                 1170             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    1175                 1180                 1185             


Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    1190                 1195                 1200             


Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 
    1205                 1210                 1215             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    1220                 1225                 1230             


Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    1235                 1240                 1245             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    1250                 1255                 1260             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    1265                 1270                 1275             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    1280                 1285                 1290             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 
    1295                 1300                 1305             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 
    1310                 1315                 1320             


Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 
    1325                 1330                 1335             


Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    1340                 1345                 1350             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 
    1355                 1360                 1365             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    1370                 1375                 1380             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 
    1385                 1390                 1395             


Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    1400                 1405                 1410             


Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 
    1415                 1420                 1425             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 
    1430                 1435                 1440             


Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    1445                 1450                 1455         


<210>  4
<211>  2813
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


