                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique (CNRS)
       Universit Montpellier 2 Sciences et Techniques
 
<120>  New Cell-Penetrating Peptide Motifs

<130>  365133D31273

<150>  13305335.5
<151>  2013-03-20

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Short consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  W (Tryptophane) can be replaced by F (Phenylalanine)

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  W (Tryptophane) can be replaced by F (Phenylalanine)

<400>  1

Trp Trp Xaa Xaa Trp Trp 
1               5       


<210>  2
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Short cell penetrating motif with WW


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Trp Trp Xaa Xaa Trp Trp 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Short cell penetrating motif with FW


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Trp Phe Xaa Xaa Trp Trp 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Short cell penetrating motif with WF


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Trp Trp Xaa Xaa Trp Phe 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Short cell penetrating motif with FF


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Trp Phe Xaa Xaa Trp Phe 
1               5       


<210>  6
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Long cell penetrating consensus motif


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  W (Tryptophan) can be replaced by F (Phenylalanin)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  W (Tryptophan) can be replaced by F (Phenylalanin)

<400>  6

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Lys Lys 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  PEP1 cell penetrating motif

<400>  7

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Lys Lys 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Long cell penetrating peptide motif with FW

<400>  8

Lys Glu Thr Trp Phe Glu Thr Trp Trp Thr Glu Lys Lys 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Long cell-penetrating peptide motif with WF

<400>  9

Lys Glu Thr Trp Trp Glu Thr Trp Phe Thr Glu Lys Lys 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  PEP2 cell-penetrating motif

<400>  10

Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Lys Lys 
1               5                   10              


<210>  11
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  PEP3 cell penetrating peptide motif

<400>  11

Lys Trp Phe Glu Thr Trp Phe Thr Glu Lys Lys 
1               5                   10      


<210>  12
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PEP1b cell-penetrating peptide motif

<400>  12

Lys Glu Thr Trp Trp Glu Thr Trp Trp 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  PEP2b cell-penetrating peptide motif

<400>  13

Lys Glu Thr Trp Phe Glu Thr Trp Phe 
1               5                   


<210>  14
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  PEP3b cell-penetrating peptide motif

<400>  14

Lys Trp Phe Glu Thr Trp Phe 
1               5           


<210>  15
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  PEP1GW cell-penetrating peptide motif

<400>  15

Gly Gly Trp Trp Gly Gly Trp Trp Gly Gly 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  PEP2GW cell-penetrating peptide motif

<400>  16

Gly Gly Trp Phe Gly Gly Trp Phe Gly Gly 
1               5                   10  


<210>  17
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  PEP3GW cell-penetrating peptide motif

<400>  17

Gly Trp Phe Gly Gly Trp Phe Gly 
1               5               


<210>  18
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  C4 peptide

<400>  18

Thr Tyr Thr Lys Lys Gln Val Leu Arg Met Ala His Leu Val Leu Lys 
1               5                   10                  15      


Val Leu Thr Phe Asp Leu Cys 
            20              


<210>  19
<211>  35
<212>  PRT
<213>  artificial

<220>
<223>  PEP1-C4 peptide

<400>  19

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Lys Lys Thr Tyr Thr 
1               5                   10                  15      


Lys Lys Val Leu Arg Met Ala His Leu Val Leu Lys Val Leu Thr Phe 
            20                  25                  30          


Asp Leu Cys 
        35  


<210>  20
<211>  42
<212>  PRT
<213>  artificial

<220>
<223>  PEP1-CDKQUANT1 peptide

<400>  20

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Lys Lys His His Ala 
1               5                   10                  15      


Gly Pro Arg Lys Arg Val His Glu Arg Tyr Cys Gly Pro Thr Ala Gly 
            20                  25                  30          


Ser Ala Lys Arg Arg Leu Phe Gly Glu Asp 
        35                  40          


<210>  21
<211>  43
<212>  PRT
<213>  artificial

<220>
<223>  PEP1-CDKQUANT3 peptide

<400>  21

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Lys Lys Pro Glu Pro 
1               5                   10                  15      


Ile Leu Val Asp Thr Ala Ser Pro Met Glu Thr Cys Gly Pro Thr Ala 
            20                  25                  30          


Gly Ser Ala Lys Arg Arg Leu Phe Gly Glu Asp 
        35                  40              


<210>  22
<211>  43
<212>  PRT
<213>  artificial

<220>
<223>  PEP1-CDKQUANT3 peptide

<400>  22

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Lys Lys Arg Ala Gly 
1               5                   10                  15      


Gly Pro Ala Thr Pro Leu Ser Pro Thr Arg Leu Cys Gly Pro Thr Ala 
            20                  25                  30          


Gly Ser Ala Lys Arg Arg Leu Phe Gly Glu Asp 
        35                  40              


<210>  23
<211>  41
<212>  PRT
<213>  artificial

<220>
<223>  PEP1-CDKQUANT4 peptide

<400>  23

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Lys Lys Tyr Lys Phe 
1               5                   10                  15      


Pro Ser Ser Pro Leu Arg Ile Pro Gly Cys Gly Pro Thr Ala Gly Ser 
            20                  25                  30          


Ala Lys Arg Arg Leu Phe Gly Glu Asp 
        35                  40      


<210>  24
<211>  44
<212>  PRT
<213>  artificial

<220>
<223>  PEP1-CDKQUANT5 peptide

<400>  24

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Lys Lys Ser Gly Tyr 
1               5                   10                  15      


Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Cys Gly Pro Thr 
            20                  25                  30          


Ala Gly Ser Ala Lys Arg Arg Leu Phe Gly Glu Asp 
        35                  40                  


<210>  25
<211>  33
<212>  PRT
<213>  artificial

<220>
<223>  PEP1-control peptide

<400>  25

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Lys Lys Val Glu Ser 
1               5                   10                  15      


Ser Asp Thr Ile Asp Asn Val Lys Ser Lys Ile Gln Asp Lys Glu Gly 
            20                  25                  30          


Cys 
    


<210>  26
<211>  33
<212>  PRT
<213>  artificial

<220>
<223>  TAT-C4

<400>  26

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Thr Tyr Thr Lys Lys Gln 
1               5                   10                  15      


Val Leu Arg Met Ala His Leu Val Leu Lys Val Leu Thr Phe Asp Leu 
            20                  25                  30          


Cys 
    


<210>  27
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  CADY1 peptide

<400>  27

Gly Leu Trp Arg Ala Leu Trp Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Trp Lys Val 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  CADY2 peptide

<400>  28

Gly Leu Trp Trp Arg Leu Trp Trp Arg Leu Arg Ser Trp Phe Arg Leu 
1               5                   10                  15      


Trp Phe Arg Val 
            20  


<210>  29
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  CDKSENS1

<400>  29

His His Ala Gly Pro Arg Lys Arg Val His Glu Arg Tyr Cys Gly Pro 
1               5                   10                  15      


Thr Ala Gly Ser Ala Lys Arg Arg Leu Phe Gly Glu Asp 
            20                  25                  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Control peptide

<400>  30

Val Glu Ser Ser Asp Thr Ile Asp Asn Val Lys Ser Lys Ile Gln Asp 
1               5                   10                  15      


Lys Glu Gly Cys 
            20  


<210>  31
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  PEP2b-C4

<400>  31

Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Tyr Thr Lys Lys Gln Val 
1               5                   10                  15      


Leu Arg Met Ala His Leu Val Leu Lys Val Leu Thr Phe Asp Leu Cys 
            20                  25                  30          


<210>  32
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  PEP3b-C4

<400>  32

Lys Trp Phe Glu Thr Trp Phe Thr Tyr Thr Lys Lys Gln Val Leu Arg 
1               5                   10                  15      


Met Ala His Leu Val Leu Lys Val Leu Thr Phe Asp Leu Cys 
            20                  25                  30  


<210>  33
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Short consensus sequence

<400>  33

Trp Trp Glu Thr Trp Trp 
1               5       


<210>  34
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Short consensus sequence

<400>  34

Trp Phe Glu Thr Trp Trp 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Short consensus sequence

<400>  35

Trp Trp Glu Thr Trp Phe 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Short consensus sequence

<400>  36

Trp Phe Glu Thr Trp Phe 
1               5       


