                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Inovio Pharmaceuticals, Inc.
       Weiner, David B.
       Yan, Jian
       Sardesai, Niranjan
       Muthumani, Karupiah
 
<120>  FOOT AND MOUTH DISEASE VIRUS (FMDV) CONSENSUS PROTEINS, CODING 
       SEQUENCES THEREFOR AND VACCINES MADE THEREFROM

<130>  133172.3302

<150>  US 61/802,225
<151>  2013-03-15

<150>  US 61/794,197
<151>  2013-03-15

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  2421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FMDV-A24cruzeiro-Long nucleic acid

<400>  1
ggatccgcca ccatggattg gacatggatt ctgttcctgg tggctgctgc tactagagtg       60

cattcagggg ccggacagtc ttcacccgca accggatcac agaaccagag tggaaatacc      120

gggagcatca ttaacaatta ctatatgcag cagtaccaga acagcatgga cacacagctg      180

ggggataacg ccatcagcgg cggcagcaat gagggctcca cagataccac atctactcac      240

actaccaata cccagaacaa tgactggttc tctaaactgg caagctccgc cttcaccggc      300

ctctttggag ctctgctcgc aaggggaaga aagaggagaa gcgataagaa aacagaggaa      360

accaccctgc tggaggacag aatcctgacc acaagaaacg ggcacactac cagcacaact      420

cagtcttcag tgggcgtcac acacggatac tcaactgagg aagaccatgt ggccgggcca      480

aataccagtg gcctggagac acgagtggtc caggctgaaa ggttctacaa gaaatatctg      540

tttgactgga ccacagataa ggccttcggc cacctggaga aactggaact cccctcagac      600

caccacggcg tgttcggcca tctggtcgat agctacgcct atatgagaaa cggatgggac      660

gtggaggtct ccgctgtggg caaccagttc aatggcggat gcctgctcgt ggctatggtg      720

cccgagtgga aggaatttga taccagggaa aaataccagc tgacactctt cccacaccag      780

tttatctctc ctagaactaa catgaccgcc catattaccg tgccttatct gggcgtcaat      840

cggtacgacc agtataagaa acacaaacct tggaccctgg tggtcatggt ggtcagtccc      900

ctcacagtga acaatactag cgccgctcag atcaaggtct acgccaacat tgctccaacc      960

tatgtgcacg tcgcaggaga gctgccttcc aaggaacggg gacgcaaacg gcgctctggg     1020

atcttcccag tggcatgtgc tgacggatac ggagggctgg tcactaccga ccctaagacc     1080

gcagatcccg cctacggaaa agtgtataac ccacccagga ctaattaccc agggcggttc     1140

accaacctgc tcgatgtggc agaggcctgc cccaccttcc tgtgctttga cgatggcaag     1200

ccatacgtga caactcggac agacgatact cgcctgctcg ccaagtttga cctgagcctc     1260

gcagccaaac acatgtcaaa cacctacctg agtggaatcg cccagtacta tactcagtat     1320

tccgggacca ttaatctgca tttcatgttt accggctcta cagactcaaa ggctcgctac     1380

atggtggcat atatccctcc cggcgtcgag accccacctg atacacctga aagggctgca     1440

cactgcatcc atgccgagtg ggacacagga ctgaacagca agttcacttt ttccattccc     1500

tacgtgtctg ccgctgacta cgcttatacc gcatccgata ctgccgaaac cattaacgtg     1560

cagggatggg tctgtatcta ccagattact cacgggaaag ccgagaatga caccctggtg     1620

gtctccgtgt ctgctggcaa ggacttcgaa ctgcgcctcc ctatcgatcc ccgacagcag     1680

cgaggcagga agcgaaggag caccacagcc accggagagt ccgctgaccc tgtgactacc     1740

acagtcgaga actacggcgg agaaacacag attcagagac ggcaccatac tgacatcgga     1800

ttcattatgg atagatttgt gaagatccag tcactgagtc ccacccacgt gattgatctc     1860

atgcagacac accagcatgg actggtgggg gccctgctcc gagcagcaac ctactacttc     1920

agcgacctgg agatcgtggt ccgccatgaa ggcaacctga catgggtgcc aaatggagcc     1980

cctgagtcag ctctgctcaa cactagtaat cccaccgcat acaacaaagc ccccttcacc     2040

cggctggcac tcccctatac agccccacac cgcgtgctgg ccacagtcta caatggcact     2100

tctaagtatg ctgtgggcgg cagcggcagg aggggcgaca tggggtccct cgctgcacgg     2160

gtggtcaagc agctgccagc ttctttcaac tacggagcaa tcaaagctga cgcaattcac     2220

gagctgctcg tgcgcatgaa gcgagcagaa ctgtattgcc ccaggccact gctcgctatc     2280

gaggtgagta gccaggacag acataagcag aaaatcattg cccccgctaa gcagctgctc     2340

agaggccgga agagacgatc taattttgac ctgctcaagc tcgccggaga cgtggaatct     2400

aatcctggat gataactcga g                                               2421


<210>  2
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A24cruzeiro-Long amino acid

<400>  2

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln 
            20                  25                  30          


Ser Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr 
        35                  40                  45              


Gln Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly 
    50                  55                  60                  


Ser Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr 
65                  70                  75                  80  


Gln Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Thr Gly 
                85                  90                  95      


Leu Phe Gly Ala Leu Leu Ala Arg Gly Arg Lys Arg Arg Ser Asp Lys 
            100                 105                 110         


Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Leu Thr Thr Arg 
        115                 120                 125             


Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val Gly Val Thr His 
    130                 135                 140                 


Gly Tyr Ser Thr Glu Glu Asp His Val Ala Gly Pro Asn Thr Ser Gly 
145                 150                 155                 160 


Leu Glu Thr Arg Val Val Gln Ala Glu Arg Phe Tyr Lys Lys Tyr Leu 
                165                 170                 175     


Phe Asp Trp Thr Thr Asp Lys Ala Phe Gly His Leu Glu Lys Leu Glu 
            180                 185                 190         


Leu Pro Ser Asp His His Gly Val Phe Gly His Leu Val Asp Ser Tyr 
        195                 200                 205             


Ala Tyr Met Arg Asn Gly Trp Asp Val Glu Val Ser Ala Val Gly Asn 
    210                 215                 220                 


Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Met Val Pro Glu Trp Lys 
225                 230                 235                 240 


Glu Phe Asp Thr Arg Glu Lys Tyr Gln Leu Thr Leu Phe Pro His Gln 
                245                 250                 255     


Phe Ile Ser Pro Arg Thr Asn Met Thr Ala His Ile Thr Val Pro Tyr 
            260                 265                 270         


Leu Gly Val Asn Arg Tyr Asp Gln Tyr Lys Lys His Lys Pro Trp Thr 
        275                 280                 285             


Leu Val Val Met Val Val Ser Pro Leu Thr Val Asn Asn Thr Ser Ala 
    290                 295                 300                 


Ala Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr Tyr Val His Val 
305                 310                 315                 320 


Ala Gly Glu Leu Pro Ser Lys Glu Arg Gly Arg Lys Arg Arg Ser Gly 
                325                 330                 335     


Ile Phe Pro Val Ala Cys Ala Asp Gly Tyr Gly Gly Leu Val Thr Thr 
            340                 345                 350         


Asp Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val Tyr Asn Pro Pro 
        355                 360                 365             


Arg Thr Asn Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala Glu 
    370                 375                 380                 


Ala Cys Pro Thr Phe Leu Cys Phe Asp Asp Gly Lys Pro Tyr Val Thr 
385                 390                 395                 400 


Thr Arg Thr Asp Asp Thr Arg Leu Leu Ala Lys Phe Asp Leu Ser Leu 
                405                 410                 415     


Ala Ala Lys His Met Ser Asn Thr Tyr Leu Ser Gly Ile Ala Gln Tyr 
            420                 425                 430         


Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr Gly 
        435                 440                 445             


Ser Thr Asp Ser Lys Ala Arg Tyr Met Val Ala Tyr Ile Pro Pro Gly 
    450                 455                 460                 


Val Glu Thr Pro Pro Asp Thr Pro Glu Arg Ala Ala His Cys Ile His 
465                 470                 475                 480 


Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro 
                485                 490                 495     


Tyr Val Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala Glu 
            500                 505                 510         


Thr Ile Asn Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His Gly 
        515                 520                 525             


Lys Ala Glu Asn Asp Thr Leu Val Val Ser Val Ser Ala Gly Lys Asp 
    530                 535                 540                 


Phe Glu Leu Arg Leu Pro Ile Asp Pro Arg Gln Gln Arg Gly Arg Lys 
545                 550                 555                 560 


Arg Arg Ser Thr Thr Ala Thr Gly Glu Ser Ala Asp Pro Val Thr Thr 
                565                 570                 575     


Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln Ile Gln Arg Arg His His 
            580                 585                 590         


Thr Asp Ile Gly Phe Ile Met Asp Arg Phe Val Lys Ile Gln Ser Leu 
        595                 600                 605             


Ser Pro Thr His Val Ile Asp Leu Met Gln Thr His Gln His Gly Leu 
    610                 615                 620                 


Val Gly Ala Leu Leu Arg Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu 
625                 630                 635                 640 


Ile Val Val Arg His Glu Gly Asn Leu Thr Trp Val Pro Asn Gly Ala 
                645                 650                 655     


Pro Glu Ser Ala Leu Leu Asn Thr Ser Asn Pro Thr Ala Tyr Asn Lys 
            660                 665                 670         


Ala Pro Phe Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val 
        675                 680                 685             


Leu Ala Thr Val Tyr Asn Gly Thr Ser Lys Tyr Ala Val Gly Gly Ser 
    690                 695                 700                 


Gly Arg Arg Gly Asp Met Gly Ser Leu Ala Ala Arg Val Val Lys Gln 
705                 710                 715                 720 


Leu Pro Ala Ser Phe Asn Tyr Gly Ala Ile Lys Ala Asp Ala Ile His 
                725                 730                 735     


Glu Leu Leu Val Arg Met Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro 
            740                 745                 750         


Leu Leu Ala Ile Glu Val Ser Ser Gln Asp Arg His Lys Gln Lys Ile 
        755                 760                 765             


Ile Ala Pro Ala Lys Gln Leu Leu Arg Gly Arg Lys Arg Arg Ser Asn 
    770                 775                 780                 


Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
785                 790                 795                 


<210>  3
<211>  2145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A24cruzeiro-Short nucleic acid

<400>  3
ggatccgcca ccatggactg gacctggatt ctgttcctcg tcgccgccgc aacacgggtg       60

cattcagaca aaaagaccga agagactaca ctcctggagg atagaatcct gaccacacgg      120

aacggccaca ctacctccac aactcagagc tccgtgggcg tcacacacgg atacagcact      180

gaggaagacc atgtggccgg gccaaatacc tccggcctgg agacaagggt ggtccaggct      240

gaaagattct acaagaagta tctcttcgac tggaccacag ataaggcctt cggacacctg      300

gagaaactgg aactcccctc tgaccaccac ggcgtgttcg gccatctggt cgattcatac      360

gcctatatga ggaacggatg ggacgtggag gtctccgctg tgggcaacca gttcaatggc      420

ggatgcctgc tcgtggctat ggtgcccgag tggaaggaat ttgataccag ggaaaaatac      480

cagctgacac tcttcccaca ccagtttatc tctcctagaa ctaacatgac cgcccatatt      540

acagtgcctt atctgggcgt caatcggtac gaccagtata agaaacacaa accttggacc      600

ctggtggtca tggtggtgag ccccctgaca gtgaacaata cttctgccgc tcagatcaag      660

gtctacgcaa acattgcccc aacctatgtg cacgtcgccg gcgagctgcc ttcaaaggaa      720

cgcggacgaa aaaggagaag tgggatcttc ccagtggcat gtgctgacgg atacggcgga      780

ctggtcacta ccgaccctaa gaccgctgat cccgcatacg ggaaagtgta taacccaccc      840

aggactaatt acccaggccg cttcaccaat ctgctcgatg tggcagaggc ctgccccacc      900

ttcctgtgct ttgacgatgg caagccatac gtgacaactc gcacagacga tactcgactg      960

ctcgccaagt ttgacctgag cctcgcagcc aaacacatga gcaacaccta cctgtccgga     1020

atcgcccagt actatactca gtatagcggg accattaatc tgcatttcat gtttaccggc     1080

tcaacagaca gtaaagcccg ctacatggtg gcttatatcc ctcccggagt cgagacccca     1140

cctgatacac ctgaaagggc tgcacactgc atccatgccg agtgggacac agggctgaac     1200

tctaagttca ctttttcaat tccctacgtg agtgccgctg actacgccta taccgccagc     1260

gatactgccg agaccatcaa cgtgcaggga tgggtctgta tctaccagat tactcacggg     1320

aaagccgaga atgacaccct ggtggtgagc gtgagcgccg gaaaggactt cgaactgcga     1380

ctccctatcg atccaaggca gcagaggggc agaaagcggc gctctaccac agcaaccgga     1440

gagtcagccg accctgtgac taccacagtc gagaactacg gaggggaaac acagattcag     1500

cgaaggcacc ataccgacat cgggttcatt atggatagat ttgtgaagat ccagtccctg     1560

tctcccacac acgtgattga tctcatgcag acccaccagc atggactggt gggggccctg     1620

ctccgagcag caacatacta cttcagcgac ctggagatcg tggtccgcca tgaaggcaac     1680

ctgacctggg tgccaaatgg agcacctgag agcgccctgc tcaacacttc caatcccacc     1740

gcttacaaca aagcaccctt caccagactg gctctcccct atacagcacc acaccgggtg     1800

ctggcaacag tctacaatgg gactagtaag tatgcagtgg gcggaagcgg cagacgggga     1860

gatatggggt ccctcgctgc acgggtggtc aagcagctgc cagcctcttt caactacggc     1920

gctatcaaag ctgacgcaat tcacgagctg ctcgtgcgaa tgaagagggc tgaactgtat     1980

tgcccccgcc cactgctcgc aatcgaggtg tcttcacagg accgacataa gcagaaaatc     2040

attgcccccg ctaagcagct gctcaggggc aggaaaagac gcagtaattt cgacctcctc     2100

aagctcgcag gcgacgtgga atctaacccc ggctgataac tcgag                     2145


<210>  4
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A24cruzeiro-Short amino acid

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile 
            20                  25                  30          


Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val 
        35                  40                  45              


Gly Val Thr His Gly Tyr Ser Thr Glu Glu Asp His Val Ala Gly Pro 
    50                  55                  60                  


Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala Glu Arg Phe Tyr 
65                  70                  75                  80  


Lys Lys Tyr Leu Phe Asp Trp Thr Thr Asp Lys Ala Phe Gly His Leu 
                85                  90                  95      


Glu Lys Leu Glu Leu Pro Ser Asp His His Gly Val Phe Gly His Leu 
            100                 105                 110         


Val Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu Val Ser 
        115                 120                 125             


Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Met Val 
    130                 135                 140                 


Pro Glu Trp Lys Glu Phe Asp Thr Arg Glu Lys Tyr Gln Leu Thr Leu 
145                 150                 155                 160 


Phe Pro His Gln Phe Ile Ser Pro Arg Thr Asn Met Thr Ala His Ile 
                165                 170                 175     


Thr Val Pro Tyr Leu Gly Val Asn Arg Tyr Asp Gln Tyr Lys Lys His 
            180                 185                 190         


Lys Pro Trp Thr Leu Val Val Met Val Val Ser Pro Leu Thr Val Asn 
        195                 200                 205             


Asn Thr Ser Ala Ala Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr 
    210                 215                 220                 


Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu Arg Gly Arg Lys 
225                 230                 235                 240 


Arg Arg Ser Gly Ile Phe Pro Val Ala Cys Ala Asp Gly Tyr Gly Gly 
                245                 250                 255     


Leu Val Thr Thr Asp Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val 
            260                 265                 270         


Tyr Asn Pro Pro Arg Thr Asn Tyr Pro Gly Arg Phe Thr Asn Leu Leu 
        275                 280                 285             


Asp Val Ala Glu Ala Cys Pro Thr Phe Leu Cys Phe Asp Asp Gly Lys 
    290                 295                 300                 


Pro Tyr Val Thr Thr Arg Thr Asp Asp Thr Arg Leu Leu Ala Lys Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Ala Lys His Met Ser Asn Thr Tyr Leu Ser Gly 
                325                 330                 335     


Ile Ala Gln Tyr Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe 
            340                 345                 350         


Met Phe Thr Gly Ser Thr Asp Ser Lys Ala Arg Tyr Met Val Ala Tyr 
        355                 360                 365             


Ile Pro Pro Gly Val Glu Thr Pro Pro Asp Thr Pro Glu Arg Ala Ala 
    370                 375                 380                 


His Cys Ile His Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr 
385                 390                 395                 400 


Phe Ser Ile Pro Tyr Val Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser 
                405                 410                 415     


Asp Thr Ala Glu Thr Ile Asn Val Gln Gly Trp Val Cys Ile Tyr Gln 
            420                 425                 430         


Ile Thr His Gly Lys Ala Glu Asn Asp Thr Leu Val Val Ser Val Ser 
        435                 440                 445             


Ala Gly Lys Asp Phe Glu Leu Arg Leu Pro Ile Asp Pro Arg Gln Gln 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Thr Thr Ala Thr Gly Glu Ser Ala Asp 
465                 470                 475                 480 


Pro Val Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln Ile Gln 
                485                 490                 495     


Arg Arg His His Thr Asp Ile Gly Phe Ile Met Asp Arg Phe Val Lys 
            500                 505                 510         


Ile Gln Ser Leu Ser Pro Thr His Val Ile Asp Leu Met Gln Thr His 
        515                 520                 525             


Gln His Gly Leu Val Gly Ala Leu Leu Arg Ala Ala Thr Tyr Tyr Phe 
    530                 535                 540                 


Ser Asp Leu Glu Ile Val Val Arg His Glu Gly Asn Leu Thr Trp Val 
545                 550                 555                 560 


Pro Asn Gly Ala Pro Glu Ser Ala Leu Leu Asn Thr Ser Asn Pro Thr 
                565                 570                 575     


Ala Tyr Asn Lys Ala Pro Phe Thr Arg Leu Ala Leu Pro Tyr Thr Ala 
            580                 585                 590         


Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Thr Ser Lys Tyr Ala 
        595                 600                 605             


Val Gly Gly Ser Gly Arg Arg Gly Asp Met Gly Ser Leu Ala Ala Arg 
    610                 615                 620                 


Val Val Lys Gln Leu Pro Ala Ser Phe Asn Tyr Gly Ala Ile Lys Ala 
625                 630                 635                 640 


Asp Ala Ile His Glu Leu Leu Val Arg Met Lys Arg Ala Glu Leu Tyr 
                645                 650                 655     


Cys Pro Arg Pro Leu Leu Ala Ile Glu Val Ser Ser Gln Asp Arg His 
            660                 665                 670         


Lys Gln Lys Ile Ile Ala Pro Ala Lys Gln Leu Leu Arg Gly Arg Lys 
        675                 680                 685             


Arg Arg Ser Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
    690                 695                 700                 


Asn Pro Gly 
705         


<210>  5
<211>  2409
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  As1-Shamir-89-Long nucleic acid

<400>  5
ggatccgcca ccatggattg gacatggatt ctgttcctgg tcgccgccgc aacacgggtg       60

cattctgggg ccggacagtc ttcacctgct actgggagcc agaaccagag cggaaataca      120

gggtccatca ttaacaatta ctatatgcag cagtaccaga acagcatgga cacccagctg      180

ggcgataacg ccatctccgg cggatctaat gagggatcta ctgacaccac atcaacacac      240

actaacaata cccagaacaa tgattggttc agtagactcg ccagctccgc tttctctgga      300

ctgtttggag cactgctcgc ccggggccgc aagaggagat ccgacaagaa aaccgaggaa      360

accaccctgc tggaggatcg aatcctgaca actaggaacg gacataccac aagcactacc      420

cagtcttcag tgggagtcac ctacgggtat gctgtcgcag aagacgccgt gagtgggccc      480

aacacaagcg gcctggagac tagagtgcag caggctgaac ggttctttaa gaaacacctc      540

ttcgattgga cacctaatct ggcctttggc cattgctact atctggagct ccccaccgaa      600

cacaaggggg tgtacggctc actgatgggg agttacgcat atatgcggaa cggatgggac      660

atcgaggtga ccgcagtcgg aaaccagttc aatggcggat gtctgctcgt ggctctggtc      720

cctgagctga aggaactcga tacaaggcag aaataccagc tgactctctt ccctcatcag      780

tttattaacc ccagaacaaa tatgactgcc cacatcaacg tgccctacgt cggcattaat      840

cggtacgacc agtatgccct ccataagcct tggaccctgg tggtcatggt ggtcgctccc      900

ctgaccgtga agacaggagg gtccgagcag atcaaagtgt acatgaacgc cgctccaacc      960

tatgtgcacg tcgccggcga gctgccttca aaggaacgag gcaggaaacg gcgctctgga     1020

attgtgccag tcgcatgcgc tgacggatac ggaaacatgg tgacaactga ccccaagacc     1080

gccgatccag tctatggaaa agtgttcaac ccacccagga ccaatctccc tgggcgattc     1140

acaaactttc tggatgtggc agaggcctgt cccacattcc tgcggtttgg ggaagtgcca     1200

ttcgtcaaga ccgtgaacag cggcgaccga ctgctcgcca aatttgacgt gagcctggcc     1260

gccggccaca tgagtaacac ctacctggct ggactcgcac agtactatac ccagtatagc     1320

gggacaatga atgtgcactt catgtttact ggcccaaccg acgctaaggc aagatacatg     1380

gtcgcctatg tgcctcccgg gatgacacca cctactgacc ctgagcacgc tgcacattgc     1440

atccacagcg aatgggatac tggcctcaac tccaaattca ccttttctat tccctacctg     1500

tcagccgctg actacgccta tacagccagc gatgtggccg agaccacatc cgtccaggga     1560

tgggtgtgca tctaccagat tacccacggc aaggctgagg gagacgcact ggtggtgagc     1620

gtgagcgccg ggaaagactt cgaatttcgg ctgcccgtgg atgcacgcca gcagagagga     1680

cggaagcgaa ggtctactac cacaactggg gaatcagccg acccagtcac cacaactgtg     1740

gagaactacg gcggagaaac ccagacagca agacggctgc acaccgacgt ggccttcatc     1800

ctcgatcgct ttgtgaagct gacagccccc aaaaatatcc agactctgga cctcatgcag     1860

attccatccc atacactggt gggcgcactg ctcaggagtg ccacttacta tttcagcgac     1920

ctggaggtcg ctctcgtgca cactggacca gtcacctggg tgcctaacgg agcaccaaag     1980

gatgctctga acaatcagac caatccaaca gcctaccaga aacagcctat caccaggctg     2040

gctctcccat atacagcacc tcacagagtc ctggctaccg tgtacaacgg aaagaccgcc     2100

tacggcgaga ccacaagccg ccgaggcgac atggcagccc tggcccagcg gctctccgct     2160

cgcctgccca catctttcaa ttacggagca gtgaaggccg atactatcac cgagctgctc     2220

attaggatga aaagagccga aacctattgc cccaggccac tgctcgctct ggacactacc     2280

caggatagga gaaagcagga gatcattgcc ccagaaaaac aggtgctgcg cggccgaaaa     2340

agacggagta atttcgacct gctcaagctc gctggcgatg tggaaagtaa tcccggatga     2400

taactcgag                                                             2409


<210>  6
<211>  795
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1-Shamir-89-Long amino acid

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln 
            20                  25                  30          


Ser Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr 
        35                  40                  45              


Gln Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly 
    50                  55                  60                  


Ser Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr 
65                  70                  75                  80  


Gln Asn Asn Asp Trp Phe Ser Arg Leu Ala Ser Ser Ala Phe Ser Gly 
                85                  90                  95      


Leu Phe Gly Ala Leu Leu Ala Arg Gly Arg Lys Arg Arg Ser Asp Lys 
            100                 105                 110         


Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Leu Thr Thr Arg 
        115                 120                 125             


Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val Gly Val Thr Tyr 
    130                 135                 140                 


Gly Tyr Ala Val Ala Glu Asp Ala Val Ser Gly Pro Asn Thr Ser Gly 
145                 150                 155                 160 


Leu Glu Thr Arg Val Gln Gln Ala Glu Arg Phe Phe Lys Lys His Leu 
                165                 170                 175     


Phe Asp Trp Thr Pro Asn Leu Ala Phe Gly His Cys Tyr Tyr Leu Glu 
            180                 185                 190         


Leu Pro Thr Glu His Lys Gly Val Tyr Gly Ser Leu Met Gly Ser Tyr 
        195                 200                 205             


Ala Tyr Met Arg Asn Gly Trp Asp Ile Glu Val Thr Ala Val Gly Asn 
    210                 215                 220                 


Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Leu Val Pro Glu Leu Lys 
225                 230                 235                 240 


Glu Leu Asp Thr Arg Gln Lys Tyr Gln Leu Thr Leu Phe Pro His Gln 
                245                 250                 255     


Phe Ile Asn Pro Arg Thr Asn Met Thr Ala His Ile Asn Val Pro Tyr 
            260                 265                 270         


Val Gly Ile Asn Arg Tyr Asp Gln Tyr Ala Leu His Lys Pro Trp Thr 
        275                 280                 285             


Leu Val Val Met Val Val Ala Pro Leu Thr Val Lys Thr Gly Gly Ser 
    290                 295                 300                 


Glu Gln Ile Lys Val Tyr Met Asn Ala Ala Pro Thr Tyr Val His Val 
305                 310                 315                 320 


Ala Gly Glu Leu Pro Ser Lys Glu Arg Gly Arg Lys Arg Arg Ser Gly 
                325                 330                 335     


Ile Val Pro Val Ala Cys Ala Asp Gly Tyr Gly Asn Met Val Thr Thr 
            340                 345                 350         


Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Phe Asn Pro Pro 
        355                 360                 365             


Arg Thr Asn Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val Ala Glu 
    370                 375                 380                 


Ala Cys Pro Thr Phe Leu Arg Phe Gly Glu Val Pro Phe Val Lys Thr 
385                 390                 395                 400 


Val Asn Ser Gly Asp Arg Leu Leu Ala Lys Phe Asp Val Ser Leu Ala 
                405                 410                 415     


Ala Gly His Met Ser Asn Thr Tyr Leu Ala Gly Leu Ala Gln Tyr Tyr 
            420                 425                 430         


Thr Gln Tyr Ser Gly Thr Met Asn Val His Phe Met Phe Thr Gly Pro 
        435                 440                 445             


Thr Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Val Pro Pro Gly Met 
    450                 455                 460                 


Thr Pro Pro Thr Asp Pro Glu His Ala Ala His Cys Ile His Ser Glu 
465                 470                 475                 480 


Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Leu 
                485                 490                 495     


Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Val Ala Glu Thr Thr 
            500                 505                 510         


Ser Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His Gly Lys Ala 
        515                 520                 525             


Glu Gly Asp Ala Leu Val Val Ser Val Ser Ala Gly Lys Asp Phe Glu 
    530                 535                 540                 


Phe Arg Leu Pro Val Asp Ala Arg Gln Gln Arg Gly Arg Lys Arg Arg 
545                 550                 555                 560 


Ser Thr Thr Thr Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr Val 
                565                 570                 575     


Glu Asn Tyr Gly Gly Glu Thr Gln Thr Ala Arg Arg Leu His Thr Asp 
            580                 585                 590         


Val Ala Phe Ile Leu Asp Arg Phe Val Lys Leu Thr Ala Pro Lys Asn 
        595                 600                 605             


Ile Gln Thr Leu Asp Leu Met Gln Ile Pro Ser His Thr Leu Val Gly 
    610                 615                 620                 


Ala Leu Leu Arg Ser Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Val Ala 
625                 630                 635                 640 


Leu Val His Thr Gly Pro Val Thr Trp Val Pro Asn Gly Ala Pro Lys 
                645                 650                 655     


Asp Ala Leu Asn Asn Gln Thr Asn Pro Thr Ala Tyr Gln Lys Gln Pro 
            660                 665                 670         


Ile Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala 
        675                 680                 685             


Thr Val Tyr Asn Gly Lys Thr Ala Tyr Gly Glu Thr Thr Ser Arg Arg 
    690                 695                 700                 


Gly Asp Met Ala Ala Leu Ala Gln Arg Leu Ser Ala Arg Leu Pro Thr 
705                 710                 715                 720 


Ser Phe Asn Tyr Gly Ala Val Lys Ala Asp Thr Ile Thr Glu Leu Leu 
                725                 730                 735     


Ile Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro Arg Pro Leu Leu Ala 
            740                 745                 750         


Leu Asp Thr Thr Gln Asp Arg Arg Lys Gln Glu Ile Ile Ala Pro Glu 
        755                 760                 765             


Lys Gln Val Leu Arg Gly Arg Lys Arg Arg Ser Asn Phe Asp Leu Leu 
    770                 775                 780                 


Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
785                 790                 795 


<210>  7
<211>  2133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  As1-Shamir-89-Short nucleic acid

<400>  7
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgccgc aactcgcgtg       60

cattcagata aaaagaccga agagactaca ctcctggaag acagaatcct gaccacaaga      120

aacggccata ctaccagcac aactcagagc tccgtgggag tcacctacgg gtatgctgtc      180

gcagaggacg ccgtgtccgg accaaacaca tctggcctgg agactcgggt gcagcaggct      240

gaacgcttct ttaagaaaca cctcttcgat tggacaccta atctggcctt tggacattgc      300

tactatctgg agctccccac cgaacacaag ggggtgtacg gcagtctgat ggggagctac      360

gcttatatga gaaacggctg ggacatcgag gtgaccgcag tcgggaacca gttcaatggc      420

ggatgtctgc tcgtggctct ggtccctgag ctgaaggaac tcgatacaag gcagaaatac      480

cagctgactc tcttccctca tcagtttatt aaccccagaa caaatatgac tgcccacatc      540

aacgtgccct acgtcggcat taatcggtac gaccagtatg cactccataa gccttggaca      600

ctggtggtca tggtggtcgc tcccctgacc gtgaagacag ggggctccga gcagatcaaa      660

gtgtacatga acgccgctcc aacctatgtg cacgtcgccg gagagctgcc ttccaaggaa      720

aggggcagaa aaaggaggag cggaattgtg ccagtcgcct gcgctgacgg ctacggaaac      780

atggtgacca cagaccccaa gaccgccgat ccagtctatg ggaaagtgtt caacccaccc      840

aggaccaatc tccctggcag gttcacaaac tttctggatg tggcagaggc ctgtcccaca      900

ttcctgcggt ttggcgaagt gccattcgtc aagaccgtga acagcggaga ccgcctgctc      960

gccaaatttg atgtgagcct ggcagccggc cacatgtcca acacctacct ggccggactc     1020

gctcagtact atacccagta tagcgggaca atgaatgtgc acttcatgtt tactggccca     1080

accgacgcta aggcacggta catggtcgcc tatgtgcctc ccggcatgac accacctact     1140

gaccctgagc acgctgcaca ttgcatccac agcgaatggg atactggact caactcaaaa     1200

ttcaccttta gtattcccta cctgagcgcc gctgactacg catatacagc ctctgatgtg     1260

gccgagacta cctcagtcca ggggtgggtg tgcatctacc agattaccca cggcaaggca     1320

gagggagacg ctctcgtggt gagcgtgagc gccggcaaag acttcgagtt caggctgcca     1380

gtggatgctc gacagcagcg gggacgcaag cggcgcagta caactaccac aggggaaagc     1440

gccgatccag tcactaccac agtggagaac tacggagggg aaacccagac agctcgaagg     1500

ctgcacaccg acgtggcatt catcctcgat cgctttgtga agctgacagc ccccaaaaat     1560

atccagactc tggacctcat gcagattcca tcccatactc tggtgggcgc tctgctcagg     1620

tccgcaacct actatttctc tgacctggag gtcgctctcg tgcacactgg accagtcacc     1680

tgggtgccta acggagcacc aaaggatgcc ctgaacaatc agaccaatcc aacagcctac     1740

cagaaacagc ctatcacccg cctggccctc ccatatacag ctcctcaccg agtcctggcc     1800

accgtgtaca acggaaagac cgcttatggg gagaccacca gcaggagggg cgacatggca     1860

gccctggcac agcgcctctc agcccgactg cccacaagtt tcaattacgg ggctgtgaag     1920

gcagatacta tcaccgagct gctcattaga atgaaacggg cagaaaccta ttgccccagg     1980

ccactgctcg ccctggacac aactcaggat cgccgaaagc aggagatcat tgccccagaa     2040

aaacaggtgc tgcgaggcag gaaaagacgc agtaatttcg acctcctcaa gctcgcaggc     2100

gacgtggaat ctaatcccgg atgataactc gag                                  2133


<210>  8
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1-Shamir-89-Short amino acid

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile 
            20                  25                  30          


Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val 
        35                  40                  45              


Gly Val Thr Tyr Gly Tyr Ala Val Ala Glu Asp Ala Val Ser Gly Pro 
    50                  55                  60                  


Asn Thr Ser Gly Leu Glu Thr Arg Val Gln Gln Ala Glu Arg Phe Phe 
65                  70                  75                  80  


Lys Lys His Leu Phe Asp Trp Thr Pro Asn Leu Ala Phe Gly His Cys 
                85                  90                  95      


Tyr Tyr Leu Glu Leu Pro Thr Glu His Lys Gly Val Tyr Gly Ser Leu 
            100                 105                 110         


Met Gly Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Ile Glu Val Thr 
        115                 120                 125             


Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Leu Val 
    130                 135                 140                 


Pro Glu Leu Lys Glu Leu Asp Thr Arg Gln Lys Tyr Gln Leu Thr Leu 
145                 150                 155                 160 


Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala His Ile 
                165                 170                 175     


Asn Val Pro Tyr Val Gly Ile Asn Arg Tyr Asp Gln Tyr Ala Leu His 
            180                 185                 190         


Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr Val Lys 
        195                 200                 205             


Thr Gly Gly Ser Glu Gln Ile Lys Val Tyr Met Asn Ala Ala Pro Thr 
    210                 215                 220                 


Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu Arg Gly Arg Lys 
225                 230                 235                 240 


Arg Arg Ser Gly Ile Val Pro Val Ala Cys Ala Asp Gly Tyr Gly Asn 
                245                 250                 255     


Met Val Thr Thr Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val 
            260                 265                 270         


Phe Asn Pro Pro Arg Thr Asn Leu Pro Gly Arg Phe Thr Asn Phe Leu 
        275                 280                 285             


Asp Val Ala Glu Ala Cys Pro Thr Phe Leu Arg Phe Gly Glu Val Pro 
    290                 295                 300                 


Phe Val Lys Thr Val Asn Ser Gly Asp Arg Leu Leu Ala Lys Phe Asp 
305                 310                 315                 320 


Val Ser Leu Ala Ala Gly His Met Ser Asn Thr Tyr Leu Ala Gly Leu 
                325                 330                 335     


Ala Gln Tyr Tyr Thr Gln Tyr Ser Gly Thr Met Asn Val His Phe Met 
            340                 345                 350         


Phe Thr Gly Pro Thr Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Val 
        355                 360                 365             


Pro Pro Gly Met Thr Pro Pro Thr Asp Pro Glu His Ala Ala His Cys 
    370                 375                 380                 


Ile His Ser Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser 
385                 390                 395                 400 


Ile Pro Tyr Leu Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Val 
                405                 410                 415     


Ala Glu Thr Thr Ser Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr 
            420                 425                 430         


His Gly Lys Ala Glu Gly Asp Ala Leu Val Val Ser Val Ser Ala Gly 
        435                 440                 445             


Lys Asp Phe Glu Phe Arg Leu Pro Val Asp Ala Arg Gln Gln Arg Gly 
    450                 455                 460                 


Arg Lys Arg Arg Ser Thr Thr Thr Thr Gly Glu Ser Ala Asp Pro Val 
465                 470                 475                 480 


Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln Thr Ala Arg Arg 
                485                 490                 495     


Leu His Thr Asp Val Ala Phe Ile Leu Asp Arg Phe Val Lys Leu Thr 
            500                 505                 510         


Ala Pro Lys Asn Ile Gln Thr Leu Asp Leu Met Gln Ile Pro Ser His 
        515                 520                 525             


Thr Leu Val Gly Ala Leu Leu Arg Ser Ala Thr Tyr Tyr Phe Ser Asp 
    530                 535                 540                 


Leu Glu Val Ala Leu Val His Thr Gly Pro Val Thr Trp Val Pro Asn 
545                 550                 555                 560 


Gly Ala Pro Lys Asp Ala Leu Asn Asn Gln Thr Asn Pro Thr Ala Tyr 
                565                 570                 575     


Gln Lys Gln Pro Ile Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His 
            580                 585                 590         


Arg Val Leu Ala Thr Val Tyr Asn Gly Lys Thr Ala Tyr Gly Glu Thr 
        595                 600                 605             


Thr Ser Arg Arg Gly Asp Met Ala Ala Leu Ala Gln Arg Leu Ser Ala 
    610                 615                 620                 


Arg Leu Pro Thr Ser Phe Asn Tyr Gly Ala Val Lys Ala Asp Thr Ile 
625                 630                 635                 640 


Thr Glu Leu Leu Ile Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro Arg 
                645                 650                 655     


Pro Leu Leu Ala Leu Asp Thr Thr Gln Asp Arg Arg Lys Gln Glu Ile 
            660                 665                 670         


Ile Ala Pro Glu Lys Gln Val Leu Arg Gly Arg Lys Arg Arg Ser Asn 
        675                 680                 685             


Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
    690                 695                 700             


<210>  9
<211>  2421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sat2-Long nucleic acid

<400>  9
ggatccgcca ccatggattg gacatggatt ctctttctgg tcgccgccgc aacacgggtg       60

cactcagggg ctggacagtc ttcacctgct acaggctctc agaaccagag tggaaatacc      120

gggagcatca ttaacaatta ctatatgcag cagtaccaga actccatgga cacccagctg      180

ggggataacg ccatctcagg cggaagtaat gaaggctcca ctgataccac atctacacac      240

actaacaata cccagaacaa tgactggttc agtaaactgg ctcagagcgc attttccgga      300

ctcgtgggag cactgctcgc taggggaaga aagaggagat cagataagaa aaccgaggaa      360

actaccctgc tggaggacag gatcgtgaca actagacatg gcaccacaac ttctaccaca      420

cagagctccg tcggaattac ctacgggtat gccgacgctg atagcttcag acctggcccc      480

aacacatccg gactggaaac tcgggtggag caggccgaac gcttctttaa gaaaaagctg      540

ttcgactgga cttctgataa gccttttgga accctccacg tgctggagct ccccaaagac      600

cagaagggga tctacggctc actgattgat gcatacgcct atacccgaaa cggatgggac      660

gtccaggtga ccgccacatc aactcagttc aatgggggca gtctgctcgt cgctatggtg      720

cccgagctgt cttcactcaa ggaaagagag gaattccagc tgacactcta tccacaccag      780

tttatcaacc ctcggaccaa tactaccgcc catattcagg tcccttacct gggagtgaac      840

cgacacgacc aggggaagcg gcatcaggcc tggtcactgg tggtcatggt gctgaccccc      900

ctcacaactg aggctcagat gaatagtgga acagtcgaag tgtacgcaaa catcgcccca      960

accaatgtct tcgtggcagg agagatgcct gcaaaacagc gaggacgaaa gcgacgaagc     1020

ggaatcattc cagtggcttg cgcagacggc tacggagggt ttcagaacac cgaccctaag     1080

acagccgatc ccatctacgg atatgtgtac aaccctagtc gcaatgattg ccacgggagg     1140

tatagcaacc tgctcgacgt ggccgaggct tgtcccacac tgctcaattt cgatggaaag     1200

ccatacgtgg tcaccaaaaa caatggggac aaggtcatgg cttgtttcga tgtggccttc     1260

acccacaaag tccataagaa cacttttctg gctggccccg cagactacta tacccagtac     1320

cagggcagcc tgaactatca cttcatgtac acagggccaa ctcaccataa agccaagttt     1380

atggtggctt atatcccccc aggggtcgag accgacaaac tgcccaagac accagaagat     1440

gccgctcact gctaccattc tgagtgggac accggcctga actcacagtt cacatttgct     1500

gtcccatatg tcagtgcaag cgacttcagc tacacccaca cagatactcc tgcaatggcc     1560

accacaaatg gctggatcgc tgtctaccag gtgaccgaca cacattccgc agaagcagca     1620

gtggtcgtgt ccgtgtctgc tggaccagac ctggagttca gatttcctat tgatcccgtg     1680

cgacagaggg gcagaaagcg aaggtctact acctcagccg gggaaggcgc tgacgtcgtg     1740

acaactgatc catctacaca cggcggagtg gagaaaagac ggatgcatac cgacgtcgcc     1800

ttcgtgctgg atcgctttac tcacgtgcat accaacaaga ccacattcaa tgtcgacctg     1860

atggatacaa aaaaggccct ggtgggagca ctgctcaggg ctagcaccta ctatttctgc     1920

gatctggaga tcgcctgtgt gggagaacac aagagagtct tttggcagcc aaacggagca     1980

cctcgaacta cccagctggg cgacaacccc atggtcttca gccacaatgt gactcgcttt     2040

gcaatcccct ataccgcccc acataggctg ctctccaccg tgtataacgg cgagtgtaaa     2100

tacacagtgg ccattagagg agaccgggct gtcctggctg caaagtacgc cactcacacc     2160

ctccctagca cattcaactt tggccatgtg actgccgaca aacccgtcga tgtgtactat     2220

cgcatgaagc gagctgaact gtattgccca aggcctctgc tcccagcata ccaccgagac     2280

cgcttcgatg ccccaatcgg cgtggagaaa cagctgtgta actttgacct gctcaaactc     2340

cgaggaagga agcgccgatc caacttcgac ctgctcaagc tggccggcga tgtggagtct     2400

aatcccggat gataactcga g                                               2421


<210>  10
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sat2-Long amino acid

<400>  10

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln 
            20                  25                  30          


Ser Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr 
        35                  40                  45              


Gln Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly 
    50                  55                  60                  


Ser Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr 
65                  70                  75                  80  


Gln Asn Asn Asp Trp Phe Ser Lys Leu Ala Gln Ser Ala Phe Ser Gly 
                85                  90                  95      


Leu Val Gly Ala Leu Leu Ala Arg Gly Arg Lys Arg Arg Ser Asp Lys 
            100                 105                 110         


Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Val Thr Thr Arg 
        115                 120                 125             


His Gly Thr Thr Thr Ser Thr Thr Gln Ser Ser Val Gly Ile Thr Tyr 
    130                 135                 140                 


Gly Tyr Ala Asp Ala Asp Ser Phe Arg Pro Gly Pro Asn Thr Ser Gly 
145                 150                 155                 160 


Leu Glu Thr Arg Val Glu Gln Ala Glu Arg Phe Phe Lys Lys Lys Leu 
                165                 170                 175     


Phe Asp Trp Thr Ser Asp Lys Pro Phe Gly Thr Leu His Val Leu Glu 
            180                 185                 190         


Leu Pro Lys Asp Gln Lys Gly Ile Tyr Gly Ser Leu Ile Asp Ala Tyr 
        195                 200                 205             


Ala Tyr Thr Arg Asn Gly Trp Asp Val Gln Val Thr Ala Thr Ser Thr 
    210                 215                 220                 


Gln Phe Asn Gly Gly Ser Leu Leu Val Ala Met Val Pro Glu Leu Ser 
225                 230                 235                 240 


Ser Leu Lys Glu Arg Glu Glu Phe Gln Leu Thr Leu Tyr Pro His Gln 
                245                 250                 255     


Phe Ile Asn Pro Arg Thr Asn Thr Thr Ala His Ile Gln Val Pro Tyr 
            260                 265                 270         


Leu Gly Val Asn Arg His Asp Gln Gly Lys Arg His Gln Ala Trp Ser 
        275                 280                 285             


Leu Val Val Met Val Leu Thr Pro Leu Thr Thr Glu Ala Gln Met Asn 
    290                 295                 300                 


Ser Gly Thr Val Glu Val Tyr Ala Asn Ile Ala Pro Thr Asn Val Phe 
305                 310                 315                 320 


Val Ala Gly Glu Met Pro Ala Lys Gln Arg Gly Arg Lys Arg Arg Ser 
                325                 330                 335     


Gly Ile Ile Pro Val Ala Cys Ala Asp Gly Tyr Gly Gly Phe Gln Asn 
            340                 345                 350         


Thr Asp Pro Lys Thr Ala Asp Pro Ile Tyr Gly Tyr Val Tyr Asn Pro 
        355                 360                 365             


Ser Arg Asn Asp Cys His Gly Arg Tyr Ser Asn Leu Leu Asp Val Ala 
    370                 375                 380                 


Glu Ala Cys Pro Thr Leu Leu Asn Phe Asp Gly Lys Pro Tyr Val Val 
385                 390                 395                 400 


Thr Lys Asn Asn Gly Asp Lys Val Met Ala Cys Phe Asp Val Ala Phe 
                405                 410                 415     


Thr His Lys Val His Lys Asn Thr Phe Leu Ala Gly Pro Ala Asp Tyr 
            420                 425                 430         


Tyr Thr Gln Tyr Gln Gly Ser Leu Asn Tyr His Phe Met Tyr Thr Gly 
        435                 440                 445             


Pro Thr His His Lys Ala Lys Phe Met Val Ala Tyr Ile Pro Pro Gly 
    450                 455                 460                 


Val Glu Thr Asp Lys Leu Pro Lys Thr Pro Glu Asp Ala Ala His Cys 
465                 470                 475                 480 


Tyr His Ser Glu Trp Asp Thr Gly Leu Asn Ser Gln Phe Thr Phe Ala 
                485                 490                 495     


Val Pro Tyr Val Ser Ala Ser Asp Phe Ser Tyr Thr His Thr Asp Thr 
            500                 505                 510         


Pro Ala Met Ala Thr Thr Asn Gly Trp Ile Ala Val Tyr Gln Val Thr 
        515                 520                 525             


Asp Thr His Ser Ala Glu Ala Ala Val Val Val Ser Val Ser Ala Gly 
    530                 535                 540                 


Pro Asp Leu Glu Phe Arg Phe Pro Ile Asp Pro Val Arg Gln Arg Gly 
545                 550                 555                 560 


Arg Lys Arg Arg Ser Thr Thr Ser Ala Gly Glu Gly Ala Asp Val Val 
                565                 570                 575     


Thr Thr Asp Pro Ser Thr His Gly Gly Val Glu Lys Arg Arg Met His 
            580                 585                 590         


Thr Asp Val Ala Phe Val Leu Asp Arg Phe Thr His Val His Thr Asn 
        595                 600                 605             


Lys Thr Thr Phe Asn Val Asp Leu Met Asp Thr Lys Lys Ala Leu Val 
    610                 615                 620                 


Gly Ala Leu Leu Arg Ala Ser Thr Tyr Tyr Phe Cys Asp Leu Glu Ile 
625                 630                 635                 640 


Ala Cys Val Gly Glu His Lys Arg Val Phe Trp Gln Pro Asn Gly Ala 
                645                 650                 655     


Pro Arg Thr Thr Gln Leu Gly Asp Asn Pro Met Val Phe Ser His Asn 
            660                 665                 670         


Val Thr Arg Phe Ala Ile Pro Tyr Thr Ala Pro His Arg Leu Leu Ser 
        675                 680                 685             


Thr Val Tyr Asn Gly Glu Cys Lys Tyr Thr Val Ala Ile Arg Gly Asp 
    690                 695                 700                 


Arg Ala Val Leu Ala Ala Lys Tyr Ala Thr His Thr Leu Pro Ser Thr 
705                 710                 715                 720 


Phe Asn Phe Gly His Val Thr Ala Asp Lys Pro Val Asp Val Tyr Tyr 
                725                 730                 735     


Arg Met Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Leu Leu Pro Ala 
            740                 745                 750         


Tyr His Arg Asp Arg Phe Asp Ala Pro Ile Gly Val Glu Lys Gln Leu 
        755                 760                 765             


Cys Asn Phe Asp Leu Leu Lys Leu Arg Gly Arg Lys Arg Arg Ser Asn 
    770                 775                 780                 


Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
785                 790                 795                 


<210>  11
<211>  2145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sat2-Short nucleic acid

<400>  11
ggatccgcca ccatggactg gacttggatt ctgttcctgg tggctgccgc aacacgggtg       60

catagcgaca aaaagaccga agagactaca ctgctggagg acagaatcgt gaccacacgg      120

cacggcacta ccacaagcac tacccagagc tccgtgggaa ttacctacgg gtatgccgac      180

gctgattctt tcagacctgg ccccaacaca tcaggactgg aaactcgcgt ggagcaggcc      240

gaacgattct ttaagaaaaa gctgttcgac tggactagtg ataagccttt tgggaccctc      300

cacgtgctgg agctccccaa agaccagaag gggatctacg gctccctgat tgatgcatac      360

gcctataccc gaaacggatg ggacgtccag gtgaccgcca caagcactca gttcaatgga      420

ggcagcctgc tcgtcgctat ggtgccagag ctgtcttcac tcaaagaaag agaggaattc      480

cagctgacac tctatccaca ccagtttatc aaccctcgga ccaatacaac tgcccatatt      540

caggtccctt acctgggagt gaacaggcac gaccagggga agagacatca ggcctggagc      600

ctggtggtca tggtgctgac ccccctcacc acagaggctc agatgaattc cgggacagtc      660

gaagtgtacg ctaacatcgc accaaccaat gtcttcgtgg ctggcgagat gcctgcaaaa      720

cagcgcgggc gaaagaggag aagcggcatc attccagtgg cttgcgcaga cggatacggg      780

ggctttcaga acaccgaccc taagacagcc gatcccatct acggctatgt gtacaaccct      840

tcccggaatg attgccacgg ccgctattct aacctgctcg acgtggccga ggcttgtccc      900

acactgctca atttcgatgg aaagccatac gtggtcacca aaaacaatgg ggacaaggtc      960

atggcctgtt tcgatgtggc ttttacacac aaagtccata agaacacttt tctggccggc     1020

cccgctgact actataccca gtaccagggc agcctgaact atcacttcat gtacacaggg     1080

ccaactcacc ataaagcaaa gtttatggtg gcctatatcc ccccaggcgt cgagaccgac     1140

aaactgccca agacaccaga agatgccgct cactgctacc atagtgagtg ggataccgga     1200

ctgaacagcc agttcacatt tgccgtccca tatgtcagtg ctagcgactt ctcttacacc     1260

cacacagata ctcctgcaat ggccactacc aatggctgga tcgccgtcta ccaggtgacc     1320

gacacacatt cagctgaagc agcagtggtc gtgtccgtgt ctgcaggacc agacctggag     1380

ttcaggtttc ctattgatcc cgtgaggcag agaggacgaa agcgacgatc aacaactagt     1440

gcaggcgaag gagccgacgt cgtgaccaca gatccatcca cacacggagg ggtggagaaa     1500

cgaaggatgc ataccgacgt cgccttcgtg ctggatcgct ttactcacgt gcataccaac     1560

aagactacct tcaatgtcga cctgatggat accaaaaagg ctctcgtggg agcactgctc     1620

agggcctcta cctactattt ctgcgatctg gagatcgcct gtgtggggga acacaagcga     1680

gtcttttggc agccaaacgg agcacctcga acaactcagc tgggcgacaa ccccatggtc     1740

ttctctcaca atgtgactcg ctttgctatc ccctataccg caccacatag gctgctctca     1800

acagtgtata acggcgagtg taaatacacc gtggcaattc gaggagaccg agcagtcctg     1860

gctgcaaagt acgccactca caccctccct tccacattca actttggcca tgtgactgcc     1920

gacaaacccg tcgatgtgta ctatcgaatg aagagggctg aactgtattg cccaagacct     1980

ctgctccccg cttaccaccg cgaccgattc gatgcaccaa tcggagtgga gaaacagctg     2040

tgtaactttg acctgctcaa actcaggggg agaaagagac ggtcaaactt cgacctgctc     2100

aagctggccg gcgatgtgga gagtaatccc ggatgataac tcgag                     2145


<210>  12
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sat2-Short amino acid

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile 
            20                  25                  30          


Val Thr Thr Arg His Gly Thr Thr Thr Ser Thr Thr Gln Ser Ser Val 
        35                  40                  45              


Gly Ile Thr Tyr Gly Tyr Ala Asp Ala Asp Ser Phe Arg Pro Gly Pro 
    50                  55                  60                  


Asn Thr Ser Gly Leu Glu Thr Arg Val Glu Gln Ala Glu Arg Phe Phe 
65                  70                  75                  80  


Lys Lys Lys Leu Phe Asp Trp Thr Ser Asp Lys Pro Phe Gly Thr Leu 
                85                  90                  95      


His Val Leu Glu Leu Pro Lys Asp Gln Lys Gly Ile Tyr Gly Ser Leu 
            100                 105                 110         


Ile Asp Ala Tyr Ala Tyr Thr Arg Asn Gly Trp Asp Val Gln Val Thr 
        115                 120                 125             


Ala Thr Ser Thr Gln Phe Asn Gly Gly Ser Leu Leu Val Ala Met Val 
    130                 135                 140                 


Pro Glu Leu Ser Ser Leu Lys Glu Arg Glu Glu Phe Gln Leu Thr Leu 
145                 150                 155                 160 


Tyr Pro His Gln Phe Ile Asn Pro Arg Thr Asn Thr Thr Ala His Ile 
                165                 170                 175     


Gln Val Pro Tyr Leu Gly Val Asn Arg His Asp Gln Gly Lys Arg His 
            180                 185                 190         


Gln Ala Trp Ser Leu Val Val Met Val Leu Thr Pro Leu Thr Thr Glu 
        195                 200                 205             


Ala Gln Met Asn Ser Gly Thr Val Glu Val Tyr Ala Asn Ile Ala Pro 
    210                 215                 220                 


Thr Asn Val Phe Val Ala Gly Glu Met Pro Ala Lys Gln Arg Gly Arg 
225                 230                 235                 240 


Lys Arg Arg Ser Gly Ile Ile Pro Val Ala Cys Ala Asp Gly Tyr Gly 
                245                 250                 255     


Gly Phe Gln Asn Thr Asp Pro Lys Thr Ala Asp Pro Ile Tyr Gly Tyr 
            260                 265                 270         


Val Tyr Asn Pro Ser Arg Asn Asp Cys His Gly Arg Tyr Ser Asn Leu 
        275                 280                 285             


Leu Asp Val Ala Glu Ala Cys Pro Thr Leu Leu Asn Phe Asp Gly Lys 
    290                 295                 300                 


Pro Tyr Val Val Thr Lys Asn Asn Gly Asp Lys Val Met Ala Cys Phe 
305                 310                 315                 320 


Asp Val Ala Phe Thr His Lys Val His Lys Asn Thr Phe Leu Ala Gly 
                325                 330                 335     


Pro Ala Asp Tyr Tyr Thr Gln Tyr Gln Gly Ser Leu Asn Tyr His Phe 
            340                 345                 350         


Met Tyr Thr Gly Pro Thr His His Lys Ala Lys Phe Met Val Ala Tyr 
        355                 360                 365             


Ile Pro Pro Gly Val Glu Thr Asp Lys Leu Pro Lys Thr Pro Glu Asp 
    370                 375                 380                 


Ala Ala His Cys Tyr His Ser Glu Trp Asp Thr Gly Leu Asn Ser Gln 
385                 390                 395                 400 


Phe Thr Phe Ala Val Pro Tyr Val Ser Ala Ser Asp Phe Ser Tyr Thr 
                405                 410                 415     


His Thr Asp Thr Pro Ala Met Ala Thr Thr Asn Gly Trp Ile Ala Val 
            420                 425                 430         


Tyr Gln Val Thr Asp Thr His Ser Ala Glu Ala Ala Val Val Val Ser 
        435                 440                 445             


Val Ser Ala Gly Pro Asp Leu Glu Phe Arg Phe Pro Ile Asp Pro Val 
    450                 455                 460                 


Arg Gln Arg Gly Arg Lys Arg Arg Ser Thr Thr Ser Ala Gly Glu Gly 
465                 470                 475                 480 


Ala Asp Val Val Thr Thr Asp Pro Ser Thr His Gly Gly Val Glu Lys 
                485                 490                 495     


Arg Arg Met His Thr Asp Val Ala Phe Val Leu Asp Arg Phe Thr His 
            500                 505                 510         


Val His Thr Asn Lys Thr Thr Phe Asn Val Asp Leu Met Asp Thr Lys 
        515                 520                 525             


Lys Ala Leu Val Gly Ala Leu Leu Arg Ala Ser Thr Tyr Tyr Phe Cys 
    530                 535                 540                 


Asp Leu Glu Ile Ala Cys Val Gly Glu His Lys Arg Val Phe Trp Gln 
545                 550                 555                 560 


Pro Asn Gly Ala Pro Arg Thr Thr Gln Leu Gly Asp Asn Pro Met Val 
                565                 570                 575     


Phe Ser His Asn Val Thr Arg Phe Ala Ile Pro Tyr Thr Ala Pro His 
            580                 585                 590         


Arg Leu Leu Ser Thr Val Tyr Asn Gly Glu Cys Lys Tyr Thr Val Ala 
        595                 600                 605             


Ile Arg Gly Asp Arg Ala Val Leu Ala Ala Lys Tyr Ala Thr His Thr 
    610                 615                 620                 


Leu Pro Ser Thr Phe Asn Phe Gly His Val Thr Ala Asp Lys Pro Val 
625                 630                 635                 640 


Asp Val Tyr Tyr Arg Met Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro 
                645                 650                 655     


Leu Leu Pro Ala Tyr His Arg Asp Arg Phe Asp Ala Pro Ile Gly Val 
            660                 665                 670         


Glu Lys Gln Leu Cys Asn Phe Asp Leu Leu Lys Leu Arg Gly Arg Lys 
        675                 680                 685             


Arg Arg Ser Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
    690                 695                 700                 


Asn Pro Gly 
705         


<210>  13
<211>  5357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A24cruzeiro-Long in pVAX nucleic acid

<400>  13
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggattgg acatggattc tgttcctggt ggctgctgct      780

actagagtgc attcaggggc cggacagtct tcacccgcaa ccggatcaca gaaccagagt      840

ggaaataccg ggagcatcat taacaattac tatatgcagc agtaccagaa cagcatggac      900

acacagctgg gggataacgc catcagcggc ggcagcaatg agggctccac agataccaca      960

tctactcaca ctaccaatac ccagaacaat gactggttct ctaaactggc aagctccgcc     1020

ttcaccggcc tctttggagc tctgctcgca aggggaagaa agaggagaag cgataagaaa     1080

acagaggaaa ccaccctgct ggaggacaga atcctgacca caagaaacgg gcacactacc     1140

agcacaactc agtcttcagt gggcgtcaca cacggatact caactgagga agaccatgtg     1200

gccgggccaa ataccagtgg cctggagaca cgagtggtcc aggctgaaag gttctacaag     1260

aaatatctgt ttgactggac cacagataag gccttcggcc acctggagaa actggaactc     1320

ccctcagacc accacggcgt gttcggccat ctggtcgata gctacgccta tatgagaaac     1380

ggatgggacg tggaggtctc cgctgtgggc aaccagttca atggcggatg cctgctcgtg     1440

gctatggtgc ccgagtggaa ggaatttgat accagggaaa aataccagct gacactcttc     1500

ccacaccagt ttatctctcc tagaactaac atgaccgccc atattaccgt gccttatctg     1560

ggcgtcaatc ggtacgacca gtataagaaa cacaaacctt ggaccctggt ggtcatggtg     1620

gtcagtcccc tcacagtgaa caatactagc gccgctcaga tcaaggtcta cgccaacatt     1680

gctccaacct atgtgcacgt cgcaggagag ctgccttcca aggaacgggg acgcaaacgg     1740

cgctctggga tcttcccagt ggcatgtgct gacggatacg gagggctggt cactaccgac     1800

cctaagaccg cagatcccgc ctacggaaaa gtgtataacc cacccaggac taattaccca     1860

gggcggttca ccaacctgct cgatgtggca gaggcctgcc ccaccttcct gtgctttgac     1920

gatggcaagc catacgtgac aactcggaca gacgatactc gcctgctcgc caagtttgac     1980

ctgagcctcg cagccaaaca catgtcaaac acctacctga gtggaatcgc ccagtactat     2040

actcagtatt ccgggaccat taatctgcat ttcatgttta ccggctctac agactcaaag     2100

gctcgctaca tggtggcata tatccctccc ggcgtcgaga ccccacctga tacacctgaa     2160

agggctgcac actgcatcca tgccgagtgg gacacaggac tgaacagcaa gttcactttt     2220

tccattccct acgtgtctgc cgctgactac gcttataccg catccgatac tgccgaaacc     2280

attaacgtgc agggatgggt ctgtatctac cagattactc acgggaaagc cgagaatgac     2340

accctggtgg tctccgtgtc tgctggcaag gacttcgaac tgcgcctccc tatcgatccc     2400

cgacagcagc gaggcaggaa gcgaaggagc accacagcca ccggagagtc cgctgaccct     2460

gtgactacca cagtcgagaa ctacggcgga gaaacacaga ttcagagacg gcaccatact     2520

gacatcggat tcattatgga tagatttgtg aagatccagt cactgagtcc cacccacgtg     2580

attgatctca tgcagacaca ccagcatgga ctggtggggg ccctgctccg agcagcaacc     2640

tactacttca gcgacctgga gatcgtggtc cgccatgaag gcaacctgac atgggtgcca     2700

aatggagccc ctgagtcagc tctgctcaac actagtaatc ccaccgcata caacaaagcc     2760

cccttcaccc ggctggcact cccctataca gccccacacc gcgtgctggc cacagtctac     2820

aatggcactt ctaagtatgc tgtgggcggc agcggcagga ggggcgacat ggggtccctc     2880

gctgcacggg tggtcaagca gctgccagct tctttcaact acggagcaat caaagctgac     2940

gcaattcacg agctgctcgt gcgcatgaag cgagcagaac tgtattgccc caggccactg     3000

ctcgctatcg aggtgagtag ccaggacaga cataagcaga aaatcattgc ccccgctaag     3060

cagctgctca gaggccggaa gagacgatct aattttgacc tgctcaagct cgccggagac     3120

gtggaatcta atcctggatg ataactcgag tctagagggc ccgtttaaac ccgctgatca     3180

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     3240

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     3300

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     3360

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctact     3420

gggcggtttt atggacagca agcgaaccgg aattgccagc tggggcgccc tctggtaagg     3480

ttgggaagcc ctgcaaagta aactggatgg ctttcttgcc gccaaggatc tgatggcgca     3540

ggggatcaag ctctgatcaa gagacaggat gaggatcgtt tcgcatgatt gaacaagatg     3600

gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat gactgggcac     3660

aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag gggcgcccgg     3720

ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaagac gaggcagcgc     3780

ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac gttgtcactg     3840

aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc ctgtcatctc     3900

accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg ctgcatacgc     3960

ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag cgagcacgta     4020

ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat caggggctcg     4080

cgccagccga actgttcgcc aggctcaagg cgagcatgcc cgacggcgag gatctcgtcg     4140

tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc ttttctggat     4200

tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg ttggctaccc     4260

gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg ctttacggta     4320

tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag ttcttctgaa     4380

ttattaacgc ttacaatttc ctgatgcggt attttctcct tacgcatctg tgcggtattt     4440

cacaccgcat caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     4500

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     4560

taatagcacg tgctaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     4620

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     4680

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     4740

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     4800

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg     4860

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     4920

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     4980

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     5040

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     5100

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     5160

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     5220

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     5280

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     5340

tttgctcaca tgttctt                                                    5357


<210>  14
<211>  5081
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A24cruzeiro-Short in pVAX nucleic acid

<400>  14
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggactgg acctggattc tgttcctcgt cgccgccgca      780

acacgggtgc attcagacaa aaagaccgaa gagactacac tcctggagga tagaatcctg      840

accacacgga acggccacac tacctccaca actcagagct ccgtgggcgt cacacacgga      900

tacagcactg aggaagacca tgtggccggg ccaaatacct ccggcctgga gacaagggtg      960

gtccaggctg aaagattcta caagaagtat ctcttcgact ggaccacaga taaggccttc     1020

ggacacctgg agaaactgga actcccctct gaccaccacg gcgtgttcgg ccatctggtc     1080

gattcatacg cctatatgag gaacggatgg gacgtggagg tctccgctgt gggcaaccag     1140

ttcaatggcg gatgcctgct cgtggctatg gtgcccgagt ggaaggaatt tgataccagg     1200

gaaaaatacc agctgacact cttcccacac cagtttatct ctcctagaac taacatgacc     1260

gcccatatta cagtgcctta tctgggcgtc aatcggtacg accagtataa gaaacacaaa     1320

ccttggaccc tggtggtcat ggtggtgagc cccctgacag tgaacaatac ttctgccgct     1380

cagatcaagg tctacgcaaa cattgcccca acctatgtgc acgtcgccgg cgagctgcct     1440

tcaaaggaac gcggacgaaa aaggagaagt gggatcttcc cagtggcatg tgctgacgga     1500

tacggcggac tggtcactac cgaccctaag accgctgatc ccgcatacgg gaaagtgtat     1560

aacccaccca ggactaatta cccaggccgc ttcaccaatc tgctcgatgt ggcagaggcc     1620

tgccccacct tcctgtgctt tgacgatggc aagccatacg tgacaactcg cacagacgat     1680

actcgactgc tcgccaagtt tgacctgagc ctcgcagcca aacacatgag caacacctac     1740

ctgtccggaa tcgcccagta ctatactcag tatagcggga ccattaatct gcatttcatg     1800

tttaccggct caacagacag taaagcccgc tacatggtgg cttatatccc tcccggagtc     1860

gagaccccac ctgatacacc tgaaagggct gcacactgca tccatgccga gtgggacaca     1920

gggctgaact ctaagttcac tttttcaatt ccctacgtga gtgccgctga ctacgcctat     1980

accgccagcg atactgccga gaccatcaac gtgcagggat gggtctgtat ctaccagatt     2040

actcacggga aagccgagaa tgacaccctg gtggtgagcg tgagcgccgg aaaggacttc     2100

gaactgcgac tccctatcga tccaaggcag cagaggggca gaaagcggcg ctctaccaca     2160

gcaaccggag agtcagccga ccctgtgact accacagtcg agaactacgg aggggaaaca     2220

cagattcagc gaaggcacca taccgacatc gggttcatta tggatagatt tgtgaagatc     2280

cagtccctgt ctcccacaca cgtgattgat ctcatgcaga cccaccagca tggactggtg     2340

ggggccctgc tccgagcagc aacatactac ttcagcgacc tggagatcgt ggtccgccat     2400

gaaggcaacc tgacctgggt gccaaatgga gcacctgaga gcgccctgct caacacttcc     2460

aatcccaccg cttacaacaa agcacccttc accagactgg ctctccccta tacagcacca     2520

caccgggtgc tggcaacagt ctacaatggg actagtaagt atgcagtggg cggaagcggc     2580

agacggggag atatggggtc cctcgctgca cgggtggtca agcagctgcc agcctctttc     2640

aactacggcg ctatcaaagc tgacgcaatt cacgagctgc tcgtgcgaat gaagagggct     2700

gaactgtatt gcccccgccc actgctcgca atcgaggtgt cttcacagga ccgacataag     2760

cagaaaatca ttgcccccgc taagcagctg ctcaggggca ggaaaagacg cagtaatttc     2820

gacctcctca agctcgcagg cgacgtggaa tctaaccccg gctgataact cgagtctaga     2880

gggcccgttt aaacccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt     2940

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     3000

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     3060

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     3120

gcggtgggct ctatggcttc tactgggcgg ttttatggac agcaagcgaa ccggaattgc     3180

cagctggggc gccctctggt aaggttggga agccctgcaa agtaaactgg atggctttct     3240

tgccgccaag gatctgatgg cgcaggggat caagctctga tcaagagaca ggatgaggat     3300

cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct tgggtggaga     3360

ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc gccgtgttcc     3420

ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga     3480

atgaactgca agacgaggca gcgcggctat cgtggctggc cacgacgggc gttccttgcg     3540

cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg ggcgaagtgc     3600

cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc atcatggctg     3660

atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac caccaagcga     3720

aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat caggatgatc     3780

tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc aaggcgagca     3840

tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg aatatcatgg     3900

tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg gcggaccgct     3960

atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc gaatgggctg     4020

accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc gccttctatc     4080

gccttcttga cgagttcttc tgaattatta acgcttacaa tttcctgatg cggtattttc     4140

tccttacgca tctgtgcggt atttcacacc gcatcaggtg gcacttttcg gggaaatgtg     4200

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     4260

caataaccct gataaatgct tcaataatag cacgtgctaa aacttcattt ttaatttaaa     4320

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     4380

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     4440

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     4500

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     4560

ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta     4620

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     4680

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     4740

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     4800

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     4860

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     4920

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     4980

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     5040

cggttcctgg ccttttgctg gccttttgct cacatgttct t                         5081


<210>  15
<211>  5345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  As1-Shamir-89-Long in pVAX nucleic acid

<400>  15
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggattgg acatggattc tgttcctggt cgccgccgca      780

acacgggtgc attctggggc cggacagtct tcacctgcta ctgggagcca gaaccagagc      840

ggaaatacag ggtccatcat taacaattac tatatgcagc agtaccagaa cagcatggac      900

acccagctgg gcgataacgc catctccggc ggatctaatg agggatctac tgacaccaca      960

tcaacacaca ctaacaatac ccagaacaat gattggttca gtagactcgc cagctccgct     1020

ttctctggac tgtttggagc actgctcgcc cggggccgca agaggagatc cgacaagaaa     1080

accgaggaaa ccaccctgct ggaggatcga atcctgacaa ctaggaacgg acataccaca     1140

agcactaccc agtcttcagt gggagtcacc tacgggtatg ctgtcgcaga agacgccgtg     1200

agtgggccca acacaagcgg cctggagact agagtgcagc aggctgaacg gttctttaag     1260

aaacacctct tcgattggac acctaatctg gcctttggcc attgctacta tctggagctc     1320

cccaccgaac acaagggggt gtacggctca ctgatgggga gttacgcata tatgcggaac     1380

ggatgggaca tcgaggtgac cgcagtcgga aaccagttca atggcggatg tctgctcgtg     1440

gctctggtcc ctgagctgaa ggaactcgat acaaggcaga aataccagct gactctcttc     1500

cctcatcagt ttattaaccc cagaacaaat atgactgccc acatcaacgt gccctacgtc     1560

ggcattaatc ggtacgacca gtatgccctc cataagcctt ggaccctggt ggtcatggtg     1620

gtcgctcccc tgaccgtgaa gacaggaggg tccgagcaga tcaaagtgta catgaacgcc     1680

gctccaacct atgtgcacgt cgccggcgag ctgccttcaa aggaacgagg caggaaacgg     1740

cgctctggaa ttgtgccagt cgcatgcgct gacggatacg gaaacatggt gacaactgac     1800

cccaagaccg ccgatccagt ctatggaaaa gtgttcaacc cacccaggac caatctccct     1860

gggcgattca caaactttct ggatgtggca gaggcctgtc ccacattcct gcggtttggg     1920

gaagtgccat tcgtcaagac cgtgaacagc ggcgaccgac tgctcgccaa atttgacgtg     1980

agcctggccg ccggccacat gagtaacacc tacctggctg gactcgcaca gtactatacc     2040

cagtatagcg ggacaatgaa tgtgcacttc atgtttactg gcccaaccga cgctaaggca     2100

agatacatgg tcgcctatgt gcctcccggg atgacaccac ctactgaccc tgagcacgct     2160

gcacattgca tccacagcga atgggatact ggcctcaact ccaaattcac cttttctatt     2220

ccctacctgt cagccgctga ctacgcctat acagccagcg atgtggccga gaccacatcc     2280

gtccagggat gggtgtgcat ctaccagatt acccacggca aggctgaggg agacgcactg     2340

gtggtgagcg tgagcgccgg gaaagacttc gaatttcggc tgcccgtgga tgcacgccag     2400

cagagaggac ggaagcgaag gtctactacc acaactgggg aatcagccga cccagtcacc     2460

acaactgtgg agaactacgg cggagaaacc cagacagcaa gacggctgca caccgacgtg     2520

gccttcatcc tcgatcgctt tgtgaagctg acagccccca aaaatatcca gactctggac     2580

ctcatgcaga ttccatccca tacactggtg ggcgcactgc tcaggagtgc cacttactat     2640

ttcagcgacc tggaggtcgc tctcgtgcac actggaccag tcacctgggt gcctaacgga     2700

gcaccaaagg atgctctgaa caatcagacc aatccaacag cctaccagaa acagcctatc     2760

accaggctgg ctctcccata tacagcacct cacagagtcc tggctaccgt gtacaacgga     2820

aagaccgcct acggcgagac cacaagccgc cgaggcgaca tggcagccct ggcccagcgg     2880

ctctccgctc gcctgcccac atctttcaat tacggagcag tgaaggccga tactatcacc     2940

gagctgctca ttaggatgaa aagagccgaa acctattgcc ccaggccact gctcgctctg     3000

gacactaccc aggataggag aaagcaggag atcattgccc cagaaaaaca ggtgctgcgc     3060

ggccgaaaaa gacggagtaa tttcgacctg ctcaagctcg ctggcgatgt ggaaagtaat     3120

cccggatgat aactcgagtc tagagggccc gtttaaaccc gctgatcagc ctcgactgtg     3180

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa     3240

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt     3300

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     3360

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctactgg gcggttttat     3420

ggacagcaag cgaaccggaa ttgccagctg gggcgccctc tggtaaggtt gggaagccct     3480

gcaaagtaaa ctggatggct ttcttgccgc caaggatctg atggcgcagg ggatcaagct     3540

ctgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga ttgcacgcag     3600

gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa cagacaatcg     3660

gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca     3720

agaccgacct gtccggtgcc ctgaatgaac tgcaagacga ggcagcgcgg ctatcgtggc     3780

tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg     3840

actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac cttgctcctg     3900

ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt gatccggcta     3960

cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact cggatggaag     4020

ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg ccagccgaac     4080

tgttcgccag gctcaaggcg agcatgcccg acggcgagga tctcgtcgtg acccatggcg     4140

atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc atcgactgtg     4200

gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt gatattgctg     4260

aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc gccgctcccg     4320

attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgaatt attaacgctt     4380

acaatttcct gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatca     4440

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     4500

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atagcacgtg     4560

ctaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     4620

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     4680

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     4740

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     4800

gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta gccgtagtta     4860

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     4920

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     4980

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     5040

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     5100

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     5160

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     5220

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     5280

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     5340

ttctt                                                                 5345


<210>  16
<211>  5069
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  As1-Shamir-89-Short in pVAX nucleic acid

<400>  16
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggactgg acctggattc tgttcctggt ggccgccgca      780

actcgcgtgc attcagataa aaagaccgaa gagactacac tcctggaaga cagaatcctg      840

accacaagaa acggccatac taccagcaca actcagagct ccgtgggagt cacctacggg      900

tatgctgtcg cagaggacgc cgtgtccgga ccaaacacat ctggcctgga gactcgggtg      960

cagcaggctg aacgcttctt taagaaacac ctcttcgatt ggacacctaa tctggccttt     1020

ggacattgct actatctgga gctccccacc gaacacaagg gggtgtacgg cagtctgatg     1080

gggagctacg cttatatgag aaacggctgg gacatcgagg tgaccgcagt cgggaaccag     1140

ttcaatggcg gatgtctgct cgtggctctg gtccctgagc tgaaggaact cgatacaagg     1200

cagaaatacc agctgactct cttccctcat cagtttatta accccagaac aaatatgact     1260

gcccacatca acgtgcccta cgtcggcatt aatcggtacg accagtatgc actccataag     1320

ccttggacac tggtggtcat ggtggtcgct cccctgaccg tgaagacagg gggctccgag     1380

cagatcaaag tgtacatgaa cgccgctcca acctatgtgc acgtcgccgg agagctgcct     1440

tccaaggaaa ggggcagaaa aaggaggagc ggaattgtgc cagtcgcctg cgctgacggc     1500

tacggaaaca tggtgaccac agaccccaag accgccgatc cagtctatgg gaaagtgttc     1560

aacccaccca ggaccaatct ccctggcagg ttcacaaact ttctggatgt ggcagaggcc     1620

tgtcccacat tcctgcggtt tggcgaagtg ccattcgtca agaccgtgaa cagcggagac     1680

cgcctgctcg ccaaatttga tgtgagcctg gcagccggcc acatgtccaa cacctacctg     1740

gccggactcg ctcagtacta tacccagtat agcgggacaa tgaatgtgca cttcatgttt     1800

actggcccaa ccgacgctaa ggcacggtac atggtcgcct atgtgcctcc cggcatgaca     1860

ccacctactg accctgagca cgctgcacat tgcatccaca gcgaatggga tactggactc     1920

aactcaaaat tcacctttag tattccctac ctgagcgccg ctgactacgc atatacagcc     1980

tctgatgtgg ccgagactac ctcagtccag gggtgggtgt gcatctacca gattacccac     2040

ggcaaggcag agggagacgc tctcgtggtg agcgtgagcg ccggcaaaga cttcgagttc     2100

aggctgccag tggatgctcg acagcagcgg ggacgcaagc ggcgcagtac aactaccaca     2160

ggggaaagcg ccgatccagt cactaccaca gtggagaact acggagggga aacccagaca     2220

gctcgaaggc tgcacaccga cgtggcattc atcctcgatc gctttgtgaa gctgacagcc     2280

cccaaaaata tccagactct ggacctcatg cagattccat cccatactct ggtgggcgct     2340

ctgctcaggt ccgcaaccta ctatttctct gacctggagg tcgctctcgt gcacactgga     2400

ccagtcacct gggtgcctaa cggagcacca aaggatgccc tgaacaatca gaccaatcca     2460

acagcctacc agaaacagcc tatcacccgc ctggccctcc catatacagc tcctcaccga     2520

gtcctggcca ccgtgtacaa cggaaagacc gcttatgggg agaccaccag caggaggggc     2580

gacatggcag ccctggcaca gcgcctctca gcccgactgc ccacaagttt caattacggg     2640

gctgtgaagg cagatactat caccgagctg ctcattagaa tgaaacgggc agaaacctat     2700

tgccccaggc cactgctcgc cctggacaca actcaggatc gccgaaagca ggagatcatt     2760

gccccagaaa aacaggtgct gcgaggcagg aaaagacgca gtaatttcga cctcctcaag     2820

ctcgcaggcg acgtggaatc taatcccgga tgataactcg agtctagagg gcccgtttaa     2880

acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     2940

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     3000

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     3060

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct     3120

atggcttcta ctgggcggtt ttatggacag caagcgaacc ggaattgcca gctggggcgc     3180

cctctggtaa ggttgggaag ccctgcaaag taaactggat ggctttcttg ccgccaagga     3240

tctgatggcg caggggatca agctctgatc aagagacagg atgaggatcg tttcgcatga     3300

ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg ctattcggct     3360

atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc     3420

aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat gaactgcaag     3480

acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca gctgtgctcg     3540

acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg gggcaggatc     3600

tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat gcaatgcggc     3660

ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa catcgcatcg     3720

agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg gacgaagagc     3780

atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgagcatg cccgacggcg     3840

aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc     3900

gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag     3960

cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg     4020

tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg     4080

agttcttctg aattattaac gcttacaatt tcctgatgcg gtattttctc cttacgcatc     4140

tgtgcggtat ttcacaccgc atcaggtggc acttttcggg gaaatgtgcg cggaacccct     4200

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     4260

taaatgcttc aataatagca cgtgctaaaa cttcattttt aatttaaaag gatctaggtg     4320

aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga     4380

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     4440

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     4500

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     4560

gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     4620

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     4680

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     4740

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     4800

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     4860

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     4920

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     4980

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc     5040

ttttgctggc cttttgctca catgttctt                                       5069


<210>  17
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1-ShamirVP4 amino acid

<400>  17

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Arg Leu Ala Ser Ser Ala Phe Ser Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala 
                85      


<210>  18
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1- cruzeiroVP4 amino acid

<400>  18

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Thr Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Leu Leu Ala 
                85      


<210>  19
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMDV-As1- shamirVP2 amino acid

<400>  19

Met Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Leu 
1               5                   10                  15      


Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val Gly 
            20                  25                  30          


Val Thr Tyr Gly Tyr Ala Val Ala Glu Asp Ala Val Ser Gly Pro Asn 
        35                  40                  45              


Thr Ser Gly Leu Glu Thr Arg Val Gln Gln Ala Glu Arg Phe Phe Lys 
    50                  55                  60                  


Lys His Leu Phe Asp Trp Thr Pro Asn Leu Ala Phe Gly His Cys Tyr 
65                  70                  75                  80  


Tyr Leu Glu Leu Pro Thr Glu His Lys Gly Val Tyr Gly Ser Leu Met 
                85                  90                  95      


Gly Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Ile Glu Val Thr Ala 
            100                 105                 110         


Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Leu Val Pro 
        115                 120                 125             


Glu Leu Lys Glu Leu Asp Thr Arg Gln Lys Tyr Gln Leu Thr Leu Phe 
    130                 135                 140                 


Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala His Ile Asn 
145                 150                 155                 160 


Val Pro Tyr Val Gly Ile Asn Arg Tyr Gly Gln Tyr Ala Leu His Lys 
                165                 170                 175     


Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr Val Lys Thr 
            180                 185                 190         


Gly Gly Ser Glu Gln Ile Lys Val Tyr Met Asn Ala Ala Pro Thr Tyr 
        195                 200                 205             


Val His Val Ala Gly Glu Leu Pro Ser Lys Glu 
    210                 215                 


<210>  20
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1- cruzeiroVP2 amino acid

<400>  20

Met Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Leu 
1               5                   10                  15      


Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val Gly 
            20                  25                  30          


Val Thr His Gly Tyr Ser Thr Glu Glu Asp His Val Ala Gly Pro Asn 
        35                  40                  45              


Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala Glu Arg Phe Tyr Lys 
    50                  55                  60                  


Lys Tyr Leu Phe Asp Trp Thr Thr Asp Lys Ala Phe Gly His Leu Glu 
65                  70                  75                  80  


Lys Leu Glu Leu Pro Ser Asp His His Gly Val Phe Gly His Leu Val 
                85                  90                  95      


Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu Val Ser Ala 
            100                 105                 110         


Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Met Val Pro 
        115                 120                 125             


Glu Trp Lys Glu Phe Asp Thr Arg Glu Lys Tyr Gln Leu Thr Leu Phe 
    130                 135                 140                 


Pro His Gln Phe Ile Ser Pro Arg Thr Asn Met Thr Ala His Ile Thr 
145                 150                 155                 160 


Val Pro Tyr Leu Gly Val Asn Arg Tyr Asp Gln Tyr Lys Lys His Lys 
                165                 170                 175     


Pro Trp Thr Leu Val Val Met Val Val Ser Pro Leu Thr Val Asn Asn 
            180                 185                 190         


Thr Ser Ala Ala Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr Tyr 
        195                 200                 205             


Val His Val Ala Gly Glu Leu Pro Ser Lys Glu 
    210                 215                 


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1- shamir2A amino acid

<400>  21

Met Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1- cruzeiro2A amino acid

<400>  22

Met Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1- shamirVP3 amino acid

<400>  23

Met Gly Ile Val Pro Val Ala Cys Ala Asp Gly Tyr Gly Asn Met Val 
1               5                   10                  15      


Thr Thr Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Phe Asn 
            20                  25                  30          


Pro Pro Arg Thr Asn Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val 
        35                  40                  45              


Ala Glu Ala Cys Pro Thr Phe Leu Arg Phe Gly Glu Val Pro Phe Val 
    50                  55                  60                  


Lys Thr Val Asn Ser Gly Asp Arg Leu Leu Ala Lys Phe Asp Val Ser 
65                  70                  75                  80  


Leu Ala Ala Gly His Met Ser Asn Thr Tyr Leu Ala Gly Leu Ala Gln 
                85                  90                  95      


Tyr Tyr Thr Gln Tyr Ser Gly Thr Met Asn Val His Phe Met Phe Thr 
            100                 105                 110         


Gly Pro Thr Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Val Pro Pro 
        115                 120                 125             


Gly Met Thr Pro Pro Thr Asp Pro Glu His Ala Ala His Cys Ile His 
    130                 135                 140                 


Ser Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro 
145                 150                 155                 160 


Tyr Leu Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Val Ala Glu 
                165                 170                 175     


Thr Thr Ser Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His Gly 
            180                 185                 190         


Lys Ala Glu Gly Asp Ala Leu Val Val Ser Val Ser Ala Gly Lys Asp 
        195                 200                 205             


Phe Glu Phe Arg Leu Pro Val Asp Ala Arg Gln Gln 
    210                 215                 220 


<210>  24
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1- cruzeiroVP3 amino acid

<400>  24

Met Gly Ile Phe Pro Val Ala Cys Ala Asp Gly Tyr Gly Gly Leu Val 
1               5                   10                  15      


Thr Thr Asp Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val Tyr Asn 
            20                  25                  30          


Pro Pro Arg Thr Asn Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val 
        35                  40                  45              


Ala Glu Ala Cys Pro Thr Phe Leu Cys Phe Asp Asp Gly Lys Pro Tyr 
    50                  55                  60                  


Val Thr Thr Arg Thr Asp Asp Thr Arg Leu Leu Ala Lys Phe Asp Leu 
65                  70                  75                  80  


Ser Leu Ala Ala Lys His Met Ser Asn Thr Tyr Leu Ser Gly Ile Ala 
                85                  90                  95      


Gln Tyr Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe 
            100                 105                 110         


Thr Gly Ser Thr Asp Ser Lys Ala Arg Tyr Met Val Ala Tyr Ile Pro 
        115                 120                 125             


Pro Gly Val Glu Thr Pro Pro Asp Thr Pro Glu Arg Ala Ala His Cys 
    130                 135                 140                 


Ile His Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser 
145                 150                 155                 160 


Ile Pro Tyr Val Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr 
                165                 170                 175     


Ala Glu Thr Ile Asn Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr 
            180                 185                 190         


His Gly Lys Ala Glu Asn Asp Thr Leu Val Val Ser Val Ser Ala Gly 
        195                 200                 205             


Lys Asp Phe Glu Leu Arg Leu Pro Ile Asp Pro Arg Gln Gln 
    210                 215                 220         


<210>  25
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1- shamirVP1 amino acid

<400>  25

Met Thr Thr Thr Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr Val 
1               5                   10                  15      


Glu Asn Tyr Gly Gly Glu Thr Gln Thr Ala Arg Arg Leu His Thr Asp 
            20                  25                  30          


Val Ala Phe Ile Leu Asp Arg Phe Val Lys Leu Thr Ala Pro Lys Asn 
        35                  40                  45              


Ile Gln Thr Leu Asp Leu Met Gln Ile Pro Ser His Thr Leu Val Gly 
    50                  55                  60                  


Ala Leu Leu Arg Ser Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Val Ala 
65                  70                  75                  80  


Leu Val His Thr Gly Pro Val Thr Trp Val Pro Asn Gly Ala Pro Lys 
                85                  90                  95      


Asp Ala Leu Asn Asn Gln Thr Asn Pro Thr Ala Tyr Gln Lys Gln Pro 
            100                 105                 110         


Ile Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala 
        115                 120                 125             


Thr Val Tyr Asn Gly Lys Thr Ala Tyr Gly Glu Thr Thr Ser Arg Arg 
    130                 135                 140                 


Gly Asp Met Ala Ala Leu Ala Gln Arg Leu Ser Ala Arg Leu Pro Thr 
145                 150                 155                 160 


Ser Phe Asn Tyr Gly Ala Val Lys Ala Asp Thr Ile Thr Glu Leu Leu 
                165                 170                 175     


Ile Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro Arg Pro Leu Leu Ala 
            180                 185                 190         


Leu Asp Thr Thr Gln Asp Arg Arg Lys Gln Glu Ile Ile Ala Pro Glu 
        195                 200                 205             


Lys Gln Val Leu 
    210         


<210>  26
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  As1- cruzeiroVP1 amino acid

<400>  26

Met Thr Thr Ala Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr Val 
1               5                   10                  15      


Glu Asn Tyr Gly Gly Glu Thr Gln Ile Gln Arg Arg His His Thr Asp 
            20                  25                  30          


Ile Gly Phe Ile Met Asp Arg Phe Val Lys Ile Gln Ser Leu Ser Pro 
        35                  40                  45              


Thr His Val Ile Asp Leu Met Gln Thr His Gln His Gly Leu Val Gly 
    50                  55                  60                  


Ala Leu Leu Arg Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile Val 
65                  70                  75                  80  


Val Arg His Glu Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro Glu 
                85                  90                  95      


Ser Ala Leu Leu Asn Thr Ser Asn Pro Thr Ala Tyr Asn Lys Ala Pro 
            100                 105                 110         


Phe Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala 
        115                 120                 125             


Thr Val Tyr Asn Gly Thr Ser Lys Tyr Ala Val Gly Gly Ser Gly Arg 
    130                 135                 140                 


Arg Gly Asp Met Gly Ser Leu Ala Ala Arg Val Val Lys Gln Leu Pro 
145                 150                 155                 160 


Ala Ser Phe Asn Tyr Gly Ala Ile Lys Ala Asp Ala Ile His Glu Leu 
                165                 170                 175     


Leu Val Arg Met Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Leu Leu 
            180                 185                 190         


Ala Ile Glu Val Ser Ser Gln Asp Arg His Lys Gln Lys Ile Ile Ala 
        195                 200                 205             


Pro Ala Lys Gln Leu Leu 
    210                 


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proteolytic cleavage site

<400>  27

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  28
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Protease C3 nucleic acid

<400>  28
tactgcgtga agaagcccgt ggccctgaag gtgaaggcca agaacaccct gatcgtgacc       60

gagagcggcg ccccccccac cgacctgcag aagatggtga tgggcaacac caagcccgtg      120

gagctgatcc tggacggcaa gaccgtggcc atctgctgcg ccaccggcgt gttcggcacc      180

gcctacctgg tgccccgcca cctgttcgcc gagaagtacg acaagatcat gctggacggc      240

cgcgccatga ccgacagcga ctaccgcgtg ttcgagttcg agatcaaggt gaagggccag      300

gacatgctga gcgacgccgc cctgatggtg ctgcaccgcg gcaaccgcgt gcgcgacatc      360

accaagcact tccgcgacac cgcccgcatg aagaagggca cccccgtggt gggcgtgatc      420

aacaacgccg acgtgggccg cctgatcttc agcggcgagg ccctgaccta caaggacatc      480

gtggtgtgca tggacggcga caccatgccc ggcctgttcg cctacaaggc cgccaccaag      540

gccggctact gcggcggcgc cgtgctggcc aaggacggcg ccgacacctt catcgtgggc      600

acccacagcg ccggcggccg caacggcgtg ggctactgca gctgcgtgag ccgcagcatg      660

ctgctgaaga tgaaggccca catcgacccc gagccccacc acgagggcct gatcgtggac      720

acccgcgacg tggaggagcg cgtgcacgtg atgtga                                756


<210>  29
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence of Consensus Protease C3

<400>  29

Tyr Cys Val Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Thr 
1               5                   10                  15      


Leu Ile Val Thr Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met 
            20                  25                  30          


Val Met Gly Asn Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr 
        35                  40                  45              


Val Ala Ile Cys Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val 
    50                  55                  60                  


Pro Arg His Leu Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly 
65                  70                  75                  80  


Arg Ala Met Thr Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys 
                85                  90                  95      


Val Lys Gly Gln Asp Met Leu Ser Asp Ala Ala Leu Met Val Leu His 
            100                 105                 110         


Arg Gly Asn Arg Val Arg Asp Ile Thr Lys His Phe Arg Asp Thr Ala 
        115                 120                 125             


Arg Met Lys Lys Gly Thr Pro Val Val Gly Val Ile Asn Asn Ala Asp 
    130                 135                 140                 


Val Gly Arg Leu Ile Phe Ser Gly Glu Ala Leu Thr Tyr Lys Asp Ile 
145                 150                 155                 160 


Val Val Cys Met Asp Gly Asp Thr Met Pro Gly Leu Phe Ala Tyr Lys 
                165                 170                 175     


Ala Ala Thr Lys Ala Gly Tyr Cys Gly Gly Ala Val Leu Ala Lys Asp 
            180                 185                 190         


Gly Ala Asp Thr Phe Ile Val Gly Thr His Ser Ala Gly Gly Arg Asn 
        195                 200                 205             


Gly Val Gly Tyr Cys Ser Cys Val Ser Arg Ser Met Leu Leu Lys Met 
    210                 215                 220                 


Lys Ala His Ile Asp Pro Glu Pro His His Glu Gly Leu Ile Val Asp 
225                 230                 235                 240 


Thr Arg Asp Val Glu Glu Arg Val His Val Met 
                245                 250     


