                         SEQUENCE LISTING

<110>  ST. JUDE CHILDREN'S RESEARCH HOSPITAL
       Zuo, Jian
       Chen, Taosheng
       Walters, Brandon
       Kuo, Bryan
       Walters, Bradley
 
<120>  METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTIONAL MODULATORS

<130>  19116.0025P1-

<150>  61/787,578
<151>  2013-03-15

<150>  61/938,404
<151>  2014-02-27

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1020
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1020)
<223>  Nucleotide sequnce for human Atoh1

<400>  1
atgtcccgcc tgctgcatgc agaagagtgg gctgaagtga aggagttggg agaccaccat       60

cgccagcccc agccgcatca tctcccgcaa ccgccgccgc cgccgcagcc acctgcaact      120

ttgcaggcga gagagcatcc cgtctacccg cctgagctgt ccctcctgga cagcaccgac      180

ccacgcgcct ggctggctcc cactttgcag ggcatctgca cggcacgcgc cgcccagtat      240

ttgctacatt ccccggagct gggtgcctca gaggccgctg cgccccggga cgaggtggac      300

ggccgggggg agctggtaag gaggagcagc ggcggtgcca gcagcagcaa gagccccggg      360

ccggtgaaag tgcgggaaca gctgtgcaag ctgaaaggcg gggtggtggt agacgagctg      420

ggctgcagcc gccaacgggc cccttccagc aaacaggtga atggggtgca gaagcagaga      480

cggctagcag ccaacgccag ggagcggcgc aggatgcatg ggctgaacca cgccttcgac      540

cagctgcgca atgttatccc gtcgttcaac aacgacaaga agctgtccaa atatgagacc      600

ctgcagatgg cccaaatcta catcaacgcc ttgtccgagc tgctacaaac gcccagcgga      660

ggggaacagc caccgccgcc tccagcctcc tgcaaaagcg accaccacca ccttcgcacc      720

gcggcctcct atgaaggggg cgcgggcaac gcgaccgcag ctggggctca gcaggcttcc      780

ggagggagcc agcggccgac cccgcccggg agttgccgga ctcgcttctc agccccagct      840

tctgcgggag ggtactcggt gcagctggac gctctgcact tctcgacttt cgaggacagc      900

gccctgacag cgatgatggc gcaaaagaat ttgtctcctt ctctccccgg gagcatcttg      960

cagccagtgc aggaggaaaa cagcaaaact tcgcctcggt cccacagaag cgacggggaa     1020


<210>  2
<211>  354
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(354)
<223>  Protein is human Atoh1

<220>
<221>  MISC_FEATURE
<222>  (1)..(354)
<223>  Protein sequence for human Atoh1

<400>  2

Met Ser Arg Leu Leu His Ala Glu Glu Trp Ala Glu Val Lys Glu Leu 
1               5                   10                  15      


Gly Asp His His Arg Gln Pro Gln Pro His His Leu Pro Gln Pro Pro 
            20                  25                  30          


Pro Pro Pro Gln Pro Pro Ala Thr Leu Gln Ala Arg Glu His Pro Val 
        35                  40                  45              


Tyr Pro Pro Glu Leu Ser Leu Leu Asp Ser Thr Asp Pro Arg Ala Trp 
    50                  55                  60                  


Leu Ala Pro Thr Leu Gln Gly Ile Cys Thr Ala Arg Ala Ala Gln Tyr 
65                  70                  75                  80  


Leu Leu His Ser Pro Glu Leu Gly Ala Ser Glu Ala Ala Ala Pro Arg 
                85                  90                  95      


Asp Glu Val Asp Gly Arg Gly Glu Leu Val Arg Arg Ser Ser Gly Gly 
            100                 105                 110         


Ala Ser Ser Ser Lys Ser Pro Gly Pro Val Lys Val Arg Glu Gln Leu 
        115                 120                 125             


Cys Lys Leu Lys Gly Gly Val Val Val Asp Glu Leu Gly Cys Ser Arg 
    130                 135                 140                 


Gln Arg Ala Pro Ser Ser Lys Gln Val Asn Gly Val Gln Lys Gln Arg 
145                 150                 155                 160 


Arg Leu Ala Ala Asn Ala Arg Glu Arg Arg Arg Met His Gly Leu Asn 
                165                 170                 175     


His Ala Phe Asp Gln Leu Arg Asn Val Ile Pro Ser Phe Asn Asn Asp 
            180                 185                 190         


Lys Lys Leu Ser Lys Tyr Glu Thr Leu Gln Met Ala Gln Ile Tyr Ile 
        195                 200                 205             


Asn Ala Leu Ser Glu Leu Leu Gln Thr Pro Ser Gly Gly Glu Gln Pro 
    210                 215                 220                 


Pro Pro Pro Pro Ala Ser Cys Lys Ser Asp His His His Leu Arg Thr 
225                 230                 235                 240 


Ala Ala Ser Tyr Glu Gly Gly Ala Gly Asn Ala Thr Ala Ala Gly Ala 
                245                 250                 255     


Gln Gln Ala Ser Gly Gly Ser Gln Arg Pro Thr Pro Pro Gly Ser Cys 
            260                 265                 270         


Arg Thr Arg Phe Ser Ala Pro Ala Ser Ala Gly Gly Tyr Ser Val Gln 
        275                 280                 285             


Leu Asp Ala Leu His Phe Ser Thr Phe Glu Asp Ser Ala Leu Thr Ala 
    290                 295                 300                 


Met Met Ala Gln Lys Asn Leu Ser Pro Ser Leu Pro Gly Ser Ile Leu 
305                 310                 315                 320 


Gln Pro Val Gln Glu Glu Asn Ser Lys Thr Ser Pro Arg Ser His Arg 
                325                 330                 335     


Ser Asp Gly Glu Phe Ser Pro His Ser His Tyr Ser Asp Ser Asp Glu 
            340                 345                 350         


Ala Ser 
        


<210>  3
<211>  2400
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2400)
<223>  Nucleotide sequence for human p27Kip1

<400>  3
cttcttcgtc agcctccctt ccaccgccat attgggccac taaaaaaagg gggctcgtct       60

tttcggggtg tttttctccc cctcccctgt ccccgcttgc tcacggctct gcgactccga      120

cgccggcaag gtttggagag cggctgggtt cgcgggaccc gcgggcttgc acccgcccag      180

actcggacgg gctttgccac cctctccgct tgcctggtcc cctctcctct ccgccctccc      240

gctcgccagt ccatttgatc agcggagact cggcggccgg gccggggctt ccccgcagcc      300

cctgcgcgct cctagagctc gggccgtggc tcgtcggggt ctgtgtcttt tggctccgag      360

ggcagtcgct gggcttccga gaggggttcg ggctgcgtag gggcgctttg ttttgttcgg      420

ttttgttttt ttgagagtgc gagagaggcg gtcgtgcaga cccgggagaa agatgtcaaa      480

cgtgcgagtg tctaacggga gccctagcct ggagcggatg gacgccaggc aggcggagca      540

ccccaagccc tcggcctgca ggaacctctt cggcccggtg gaccacgaag agttaacccg      600

ggacttggag aagcactgca gagacatgga agaggcgagc cagcgcaagt ggaatttcga      660

ttttcagaat cacaaacccc tagagggcaa gtacgagtgg caagaggtgg agaagggcag      720

cttgcccgag ttctactaca gacccccgcg gccccccaaa ggtgcctgca aggtgccggc      780

gcaggagagc caggatgtca gcgggagccg cccggcggcg cctttaattg gggctccggc      840

taactctgag gacacgcatt tggtggaccc aaagactgat ccgtcggaca gccagacggg      900

gttagcggag caatgcgcag gaataaggaa gcgacctgca accgacgatt cttctactca      960

aaacaaaaga gccaacagaa cagaagaaaa tgtttcagac ggttccccaa atgccggttc     1020

tgtggagcag acgcccaaga agcctggcct cagaagacgt caaacgtaaa cagctcgaat     1080

taagaatatg tttccttgtt tatcagatac atcactgctt gatgaagcaa ggaagatata     1140

catgaaaatt ttaaaaatac atatcgctga cttcatggaa tggacatcct gtataagcac     1200

tgaaaaacaa caacacaata acactaaaat tttaggcact cttaaatgat ctgcctctaa     1260

aagcgttgga tgtagcatta tgcaattagg tttttcctta tttgcttcat tgtactacct     1320

gtgtatatag tttttacctt ttatgtagca cataaacttt ggggaaggga gggcagggtg     1380

gggctgagga actgacgtgg agcggggtat gaagagcttg ctttgattta cagcaagtag     1440

ataaatattt gacttgcatg aagagaagca attttgggga agggtttgaa ttgttttctt     1500

taaagatgta atgtcccttt cagagacagc tgatacttca tttaaaaaaa tcacaaaaat     1560

ttgaacactg gctaaagata attgctattt atttttacaa gaagtttatt ctcatttggg     1620

agatctggtg atctcccaag ctatctaaag tttgttagat agctgcatgt ggctttttta     1680

aaaaagcaac agaaacctat cctcactgcc ctccccagtc tctcttaaag ttggaattta     1740

ccagttaatt actcagcaga atggtgatca ctccaggtag tttggggcaa aaatccgagg     1800

tgcttgggag ttttgaatgt taagaattga ccatctgctt ttattaaatt tgttgacaaa     1860

attttctcat tttcttttca cttcgggctg tgtaaacaca gtcaaaataa ttctaaatcc     1920

ctcgatattt ttaaagatct gtaagtaact tcacattaaa aaatgaaata ttttttaatt     1980

taaagcttac tctgtccatt tatccacagg aaagtgttat ttttcaagga aggttcatgt     2040

agagaaaagc acacttgtag gataagtgaa atggatacta catctttaaa cagtatttca     2100

ttgcctgtgt atggaaaaac catttgaagt gtacctgtgt acataactct gtaaaaacac     2160

tgaaaaatta tactaactta tttatgttaa aagatttttt ttaatctaga caatatacaa     2220

gccaaagtgg catgttttgt gcatttgtaa atgctgtgtt gggtagaata ggttttcccc     2280

tcttttgtta aataatatgg ctatgcttaa aaggttgcat actgagccaa gtataatttt     2340

ttgtaatgtg tgaaaaagat gccaattatt gttacacatt aagtaatcaa taaagaaaac     2400


<210>  4
<211>  198
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(198)
<223>  Protein sequence for human p27Kip1

<400>  4

Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met 
1               5                   10                  15      


Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu 
            20                  25                  30          


Phe Gly Pro Val Asp His Glu Glu Leu Thr Arg Asp Leu Glu Lys His 
        35                  40                  45              


Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe 
    50                  55                  60                  


Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu 
65                  70                  75                  80  


Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys 
                85                  90                  95      


Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser 
            100                 105                 110         


Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Thr 
        115                 120                 125             


His Leu Val Asp Pro Lys Thr Asp Pro Ser Asp Ser Gln Thr Gly Leu 
    130                 135                 140                 


Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Thr Asp Asp Ser 
145                 150                 155                 160 


Ser Thr Gln Asn Lys Arg Ala Asn Arg Thr Glu Glu Asn Val Ser Asp 
                165                 170                 175     


Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly 
            180                 185                 190         


Leu Arg Arg Arg Gln Thr 
        195             


