                         SEQUENCE LISTING

<110>  Ying BUECHLER et al.
 
<120>  HISTIDYL-TRNA SYNTHETASE-FC CONJUGATES

<130>  ATYR-116/01WO

<150>  US 61/789,011
<151>  2013-03-15

<160>  396   

<170>  PatentIn version 3.5

<210>  1
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  2
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser 
            100                 105                 110         


Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu 
        115                 120                 125             


Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys 
    130                 135                 140                 


Val Lys Lys Met Lys Arg Tyr His Val Gly Lys Val Trp Arg Arg Glu 
145                 150                 155                 160 


Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp 
                165                 170                 175     


Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys 
            180                 185                 190         


Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe 
        195                 200                 205             


Leu Ile Lys Val Asn Asp Arg Arg Ile Val Asp Gly Met Phe Ala Val 
    210                 215                 220                 


Cys Gly Val Pro Glu Ser Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp 
225                 230                 235                 240 


Lys Leu Asp Lys Met Ala Trp Lys Asp Val Arg His Glu Met Val Val 
                245                 250                 255     


Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val 
            260                 265                 270         


Gln Cys His Gly Gly Val Ser Leu Val Glu Gln Met Phe Gln Asp Pro 
        275                 280                 285             


Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys 
    290                 295                 300                 


Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser 
305                 310                 315                 320 


Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile 
                325                 330                 335     


Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro 
            340                 345                 350         


Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val 
        355                 360                 365             


Gly Met Phe Asp Pro Lys Gly His Lys Val Pro Cys Val Gly Leu Ser 
    370                 375                 380                 


Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln Arg Met Lys Thr 
385                 390                 395                 400 


Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val Phe Val Ala Thr 
                405                 410                 415     


Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu 
            420                 425                 430         


Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys 
        435                 440                 445             


Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val 
    450                 455                 460                 


Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val Ile Lys Ile Arg 
465                 470                 475                 480 


Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg Glu Asn Phe Val 
                485                 490                 495     


Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505     


<210>  3
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met 
    130                 135                 140     


<210>  4
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu 
                405             


<210>  5
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu 
    


<210>  6
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  7
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Gly Tyr Pro Trp Trp Asn Ser Cys Ser Arg Ile Leu 
                245                 250                 255     


Asn Tyr Pro Lys Thr Ser Arg Pro Trp Arg Ala Trp Glu Thr 
            260                 265                 270 


<210>  8
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu 
1               5                   10                  15      


Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile 
            20                  25                  30          


Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu 
        35                  40                  45              


Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu 
    50                  55                  60                  


Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg 
65                  70                  75                  80  


Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg 
                85                  90                  95      


Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            100                 105 


<210>  9
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Asp Phe Asp Ile 
    50                  55                  60                  


Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile 
65                  70                  75                  80  


Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys 
                85                  90                  95      


Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val 
            100                 105                 110         


Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp 
        115                 120                 125             


Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly 
    130                 135                 140                 


Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His 
145                 150                 155                 160 


Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser 
                165                 170                 175     


Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe 
            180                 185                 190         


Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu 
        195                 200                 205             


Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala 
    210                 215                 220                 


Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val 
225                 230                 235                 240 


Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe 
                245                 250                 255     


Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val 
            260                 265                 270         


Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu 
        275                 280                 285             


Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys 
    290                 295                 300                 


Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala 
305                 310                 315                 320 


Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn 
                325                 330                 335     


Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile 
            340                 345                 350         


Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr 
        355                 360                 365             


Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile 
    370                 375                 380                 


Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
385                 390                 395 


<210>  10
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Val Asn Asp Arg 
    50                  55                  60                  


Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys 
65                  70                  75                  80  


Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp 
                85                  90                  95      


Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu 
            100                 105                 110         


Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser 
        115                 120                 125             


Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln 
    130                 135                 140                 


Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr 
145                 150                 155                 160 


Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg 
                165                 170                 175     


Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln 
            180                 185                 190         


Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala 
        195                 200                 205             


Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly 
    210                 215                 220                 


Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe 
225                 230                 235                 240 


Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr 
                245                 250                 255     


Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu 
            260                 265                 270         


Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala 
        275                 280                 285             


Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr 
    290                 295                 300                 


Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu 
305                 310                 315                 320 


Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu 
                325                 330                 335     


Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr 
            340                 345                 350         


Gly Gln Pro Leu Cys Ile Cys 
        355                 


<210>  11
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala 
            100                 105                 110         


Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val 
        115                 120                 125             


Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val 
    130                 135                 140                 


Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr 
145                 150                 155                 160 


Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp 
                165                 170                 175     


Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu 
            180                 185                 190         


Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile 
        195                 200                 205             


Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val 
    210                 215                 220                 


Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu 
225                 230                 235                 240 


Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu 
                245                 250                 255     


Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu 
            260                 265                 270         


Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu 
        275                 280                 285             


Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala 
    290                 295                 300                 


Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu 
305                 310                 315                 320 


Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro 
                325                 330                 335     


Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu 
            340                 345                 350         


Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu 
        355                 360                 365             


Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu 
    370                 375                 380                 


Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
385                 390                 395                 


<210>  12
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Val Asn 
                165                 170                 175     


Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp 
            180                 185                 190         


Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val 
        195                 200                 205             


Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala 
    210                 215                 220                 


Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly 
225                 230                 235                 240 


Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn 
                245                 250                 255     


Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr 
            260                 265                 270         


Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu 
        275                 280                 285             


Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu 
    290                 295                 300                 


Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser 
305                 310                 315                 320 


Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro 
                325                 330                 335     


Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg 
            340                 345                 350         


Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile 
        355                 360                 365             


Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu 
    370                 375                 380                 


Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile 
385                 390                 395                 400 


Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu 
                405                 410                 415     


Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu 
            420                 425                 430         


Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg 
        435                 440                 445             


Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg 
    450                 455                 460                 


Arg Thr Gly Gln Pro Leu Cys Ile Cys 
465                 470             


<210>  13
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Glu Thr Leu Met 
    50                  55                  60                  


Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln 
65                  70                  75                  80  


Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala 
                85                  90                  95      


Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile 
            100                 105                 110         


Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr 
        115                 120                 125             


Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro 
    130                 135                 140                 


Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser 
145                 150                 155                 160 


Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile 
                165                 170                 175     


Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg 
            180                 185                 190         


Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu 
        195                 200                 205             


Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala 
    210                 215                 220                 


Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val 
225                 230                 235                 240 


Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu 
                245                 250                 255     


Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe 
            260                 265                 270         


Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu 
        275                 280                 285             


Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro 
    290                 295                 300                 


Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly 
305                 310                 315                 320 


Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys 
                325                 330                 335     


Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile 
            340                 345                 350         


Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu 
        355                 360                 365             


Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg 
    370                 375                 380                 


Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu 
385                 390                 395                 400 


Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu 
                405                 410                 415     


Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys 
            420                 425                 430         


Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp 
        435                 440                 445             


Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln 
    450                 455                 460                 


Pro Leu Cys Ile Cys 
465                 


<210>  14
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile 
            100                 105                 110         


Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu 
        115                 120                 125             


Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp 
    130                 135                 140                 


Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile 
145                 150                 155                 160 


Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys 
                165                 170                 175     


Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg 
            180                 185                 190         


Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln 
        195                 200                 205             


Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly 
    210                 215                 220                 


Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile 
225                 230                 235                 240 


Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr 
                245                 250                 255     


Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln 
            260                 265                 270         


Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg 
        275                 280                 285             


Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro 
    290                 295                 300                 


Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu 
305                 310                 315                 320 


Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln 
                325                 330                 335     


Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys 
            340                 345                 350         


Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr 
        355                 360                 365             


Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala 
    370                 375                 380                 


Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly 
385                 390                 395                 400 


Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg 
                405                 410                 415     


Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            420                 425                 430         


Cys Ile Cys 
        435 


<210>  15
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ala Leu Glu Glu 
    50                  55                  60                  


Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys 
65                  70                  75                  80  


Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala 
                85                  90                  95      


Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn 
            100                 105                 110         


Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile 
        115                 120                 125             


Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr 
    130                 135                 140                 


Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile 
145                 150                 155                 160 


Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
                165                 170     


<210>  16
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln 
            100                 105                 110         


Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys 
        115                 120                 125             


Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr 
    130                 135                 140                 


Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala 
145                 150                 155                 160 


Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly 
                165                 170                 175     


Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg 
            180                 185                 190         


Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
        195                 200                 205             


Cys Ile Cys 
    210     


<210>  17
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
1               5                   10                  15      


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
            20                  25                  30          


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
        35                  40                  45              


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
    50                  55                  60                  


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
65                  70                  75                  80  


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
                85                  90                  95      


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
            100                 105                 110         


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
        115                 120                 125             


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
    130                 135                 140     


<210>  18
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp 
1               5                   10                  15      


Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala 
            20                  25                  30          


Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val 
        35                  40                  45              


Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val 
    50                  55                  60                  


Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr 
65                  70                  75                  80  


Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp 
                85                  90                  95      


Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu 
            100                 105                 110         


Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile 
        115                 120                 125             


Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly 
    130                 135                 140             


<210>  19
<211>  509
<212>  PRT
<213>  Mus musuculus

<400>  19

Met Ala Asp Arg Ala Ala Leu Glu Glu Leu Val Arg Leu Gln Gly Ala 
1               5                   10                  15      


His Val Arg Gly Leu Lys Glu Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Thr Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Gln Asp 
        35                  40                  45              


Glu Gly Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asn Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Val Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Ile Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Met Pro Thr Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Ile Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Ser 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Trp Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Arg Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Ala Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Arg Arg Arg Thr Asn Gln Pro Leu Ser Thr Cys 
            500                 505                 


<210>  20
<211>  509
<212>  PRT
<213>  Canis lupus familiaris

<400>  20

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Arg Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Gly Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Ser Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Glu Ile Met Cys Glu Ile Leu Arg Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp His Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Ile Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Glu 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Val Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Thr 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asn Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Ala Ser Arg Glu Glu Val Asp Val Pro Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Ser Gln Pro Phe Cys Ile Cys 
            500                 505                 


<210>  21
<211>  509
<212>  PRT
<213>  Bos taurus

<400>  21

Met Ala Asp Arg Ala Ala Leu Glu Asp Leu Val Arg Val Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Gly Lys Pro Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Ser Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Leu Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Pro Pro Ala Arg Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Ile Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Thr Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Ala Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Ser Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  22
<211>  508
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Met Ala Asp Arg Ala Ala Leu Glu Glu Leu Val Arg Leu Gln Gly Ala 
1               5                   10                  15      


His Val Arg Gly Leu Lys Glu Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Thr Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly His Asp 
        35                  40                  45              


Glu Gly Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asn Phe Gln 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Val Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Met Pro Thr Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Ile Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Lys Leu Glu Ala Ser 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Ile Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Arg Arg Arg Thr Ser Gln Pro Leu Ser Met 
            500                 505             


<210>  23
<211>  500
<212>  PRT
<213>  Gallus gallus

<400>  23

Met Ala Asp Glu Ala Ala Val Arg Gln Gln Ala Glu Val Val Arg Arg 
1               5                   10                  15      


Leu Lys Gln Asp Lys Ala Glu Pro Asp Glu Ile Ala Lys Glu Val Ala 
            20                  25                  30          


Lys Leu Leu Glu Met Lys Ala His Leu Gly Gly Asp Glu Gly Lys His 
        35                  40                  45              


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Gly Pro Lys 
    50                  55                  60                  


Gln Met Ala Ile Arg Glu Arg Val Phe Ser Ala Ile Ile Ala Cys Phe 
65                  70                  75                  80  


Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val Phe Glu Leu Lys 
                85                  90                  95      


Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp 
            100                 105                 110         


Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr 
        115                 120                 125             


Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Ile Thr Asn Ile Lys 
    130                 135                 140                 


Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr 
145                 150                 155                 160 


Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly 
                165                 170                 175     


Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Val Gln 
            180                 185                 190         


Glu Ile Leu Ser Asp Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn 
        195                 200                 205             


Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys Gly Val Pro Asp 
    210                 215                 220                 


Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Met 
225                 230                 235                 240 


Pro Trp Glu Glu Val Arg Asn Glu Met Val Gly Glu Lys Gly Leu Ser 
                245                 250                 255     


Pro Glu Ala Ala Asp Arg Ile Gly Glu Tyr Val Gln Leu His Gly Gly 
            260                 265                 270         


Met Asp Leu Ile Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn 
        275                 280                 285             


Lys Leu Val Lys Glu Gly Leu Gly Asp Met Lys Leu Leu Phe Glu Tyr 
    290                 295                 300                 


Leu Thr Leu Phe Gly Ile Thr Gly Lys Ile Ser Phe Asp Leu Ser Leu 
305                 310                 315                 320 


Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu 
                325                 330                 335     


Leu Gln Gln Asn Asp His Gly Glu Glu Ser Val Ser Val Gly Ser Val 
            340                 345                 350         


Ala Gly Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys 
        355                 360                 365             


Gly Arg Lys Val Pro Cys Val Gly Ile Ser Ile Gly Ile Glu Arg Ile 
    370                 375                 380                 


Phe Ser Ile Leu Glu Gln Arg Val Glu Ala Ser Glu Glu Lys Ile Arg 
385                 390                 395                 400 


Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu 
                405                 410                 415     


Glu Glu Arg Leu Lys Leu Ile Ser Glu Leu Trp Asp Ala Gly Ile Lys 
            420                 425                 430         


Ala Glu Val Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln 
        435                 440                 445             


Tyr Cys Glu Asp Thr Gly Ile Pro Leu Val Ala Ile Val Gly Glu Gln 
    450                 455                 460                 


Glu Leu Lys Asp Gly Val Val Lys Leu Arg Val Val Ala Thr Gly Glu 
465                 470                 475                 480 


Glu Val Asn Ile Arg Arg Glu Ser Leu Val Glu Glu Ile Arg Arg Arg 
                485                 490                 495     


Thr Asn Gln Leu 
            500 


<210>  24
<211>  437
<212>  PRT
<213>  Danio rerio

<400>  24

Met Ala Ala Leu Gly Leu Val Ser Met Arg Leu Cys Ala Gly Leu Met 
1               5                   10                  15      


Gly Arg Arg Ser Ala Val Arg Leu His Ser Leu Arg Val Cys Ser Gly 
            20                  25                  30          


Met Thr Ile Ser Gln Ile Asp Glu Glu Val Ala Arg Leu Leu Gln Leu 
        35                  40                  45              


Lys Ala Gln Leu Gly Gly Asp Glu Gly Lys His Val Phe Val Leu Lys 
    50                  55                  60                  


Thr Ala Lys Gly Thr Arg Asp Tyr Asn Pro Lys Gln Met Ala Ile Arg 
65                  70                  75                  80  


Glu Lys Val Phe Asn Ile Ile Ile Asn Cys Phe Lys Arg His Gly Ala 
                85                  90                  95      


Glu Thr Ile Asp Ser Pro Val Phe Glu Leu Lys Glu Thr Leu Thr Gly 
            100                 105                 110         


Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly 
        115                 120                 125             


Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg 
    130                 135                 140                 


Tyr Leu Ala Met Asn Lys Ile Thr Asn Ile Lys Arg Tyr His Ile Ala 
145                 150                 155                 160 


Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg 
                165                 170                 175     


Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Gln Tyr Asp Ala Met 
            180                 185                 190         


Ile Pro Asp Ala Glu Cys Leu Lys Leu Val Tyr Glu Ile Leu Ser Glu 
        195                 200                 205             


Leu Asp Leu Gly Asp Phe Arg Ile Lys Val Asn Asp Arg Arg Ile Leu 
    210                 215                 220                 


Asp Gly Met Phe Ala Ile Cys Gly Val Pro Asp Glu Lys Phe Arg Thr 
225                 230                 235                 240 


Ile Cys Ser Thr Val Asp Lys Leu Asp Lys Leu Ala Trp Glu Glu Val 
                245                 250                 255     


Lys Lys Glu Met Val Asn Glu Lys Gly Leu Ser Glu Glu Val Ala Asp 
            260                 265                 270         


Arg Ile Arg Asp Tyr Val Ser Met Gln Gly Gly Lys Asp Leu Ala Glu 
        275                 280                 285             


Arg Leu Leu Gln Asp Pro Lys Leu Ser Gln Ser Lys Gln Ala Cys Ala 
    290                 295                 300                 


Gly Ile Thr Asp Met Lys Leu Leu Phe Ser Tyr Leu Glu Leu Phe Gln 
305                 310                 315                 320 


Ile Thr Asp Lys Val Val Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp 
                325                 330                 335     


Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Ile Leu Thr Gln Ala Asn Pro 
            340                 345                 350         


Ala Pro Ala Ser Thr Pro Ala Glu Gln Asn Gly Ala Glu Asp Ala Gly 
        355                 360                 365             


Val Ser Val Gly Ser Val Ala Gly Gly Gly Arg Tyr Asp Gly Leu Val 
    370                 375                 380                 


Gly Met Phe Asp Pro Lys Ala Gly Lys Cys Pro Val Trp Gly Ser Ala 
385                 390                 395                 400 


Leu Ala Leu Arg Gly Ser Ser Pro Ser Trp Ser Arg Arg Gln Ser Cys 
                405                 410                 415     


Leu Gln Arg Arg Cys Ala Pro Leu Lys Leu Lys Cys Leu Trp Leu Gln 
            420                 425                 430         


His Arg Arg Thr Phe 
        435         


<210>  25
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  26
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


<210>  27
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


<210>  28
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val 
65                  70                  75                  


<210>  29
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp 
65                  70                  75              


<210>  30
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
65                  70                  75          


<210>  31
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
65                  70                  75      


<210>  32
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys 
65                  70                  75  


<210>  33
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu 
65                  70                  


<210>  34
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg 
65                  70              


<210>  35
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val 
65                  70          


<210>  36
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala 
65                  70      


<210>  37
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met 
65                  70  


<210>  38
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln 
65                  


<210>  39
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg 
65              


<210>  40
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro 
65          


<210>  41
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser 
65      


<210>  42
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr 
65  


<210>  43
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


<210>  44
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60              


<210>  45
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr 
    50                  55                  60          


<210>  46
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
    50                  55                  60      


<210>  47
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  48
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro 
    50                  55                  


<210>  49
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr 
    50                  55              


<210>  50
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys 
    50                  55          


<210>  51
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu 
    50                  55      


<210>  52
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val 
    50                  55  


<210>  53
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe 
    50                  


<210>  54
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys 
    50              


<210>  55
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln 
    50          


<210>  56
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys 
    50      


<210>  57
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser 
    50  


<210>  58
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu 
    


<210>  59
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


<210>  60
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
        35                  40                  45          


<210>  61
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly 
        35                  40                  45      


<210>  62
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
        35                  40                  45  


<210>  63
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
        35                  40                  


<210>  64
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala 
        35                  40              


<210>  65
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys 
        35                  40          


<210>  66
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu 
        35                  40      


<210>  67
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys 
        35                  40  


<210>  68
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg 
1               5                   10                  15      


Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
            20                  25                  30          


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
        35                  40                  45              


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
    50                  55                  60                  


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  


<210>  69
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  69

Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val 
1               5                   10                  15      


Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu 
            20                  25                  30          


Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
        35                  40                  45              


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser 
    50                  55                  60                  


Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75              


<210>  70
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  70

Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg 
1               5                   10                  15      


Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val 
            20                  25                  30          


Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys 
        35                  40                  45              


Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro 
    50                  55                  60                  


Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75          


<210>  71
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  71

Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly 
1               5                   10                  15      


Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala 
            20                  25                  30          


Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln 
        35                  40                  45              


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg 
    50                  55                  60                  


Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75      


<210>  72
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  72

Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu 
1               5                   10                  15      


Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys 
            20                  25                  30          


Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys 
        35                  40                  45              


Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
    50                  55                  60                  


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75  


<210>  73
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  73

Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys 
1               5                   10                  15      


Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu 
            20                  25                  30          


Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe 
        35                  40                  45              


Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met 
    50                  55                  60                  


Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  


<210>  74
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  74

Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln 
1               5                   10                  15      


Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu 
            20                  25                  30          


Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
        35                  40                  45              


Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala 
    50                  55                  60                  


Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70              


<210>  75
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  75

Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln 
1               5                   10                  15      


Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys 
            20                  25                  30          


Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu 
        35                  40                  45              


Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val 
    50                  55                  60                  


Arg Glu Lys Val Phe Asp Val Ile 
65                  70          


<210>  76
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  76

Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys 
1               5                   10                  15      


Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu 
            20                  25                  30          


Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys 
        35                  40                  45              


Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg 
    50                  55                  60                  


Glu Lys Val Phe Asp Val Ile 
65                  70      


<210>  77
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  77

Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala 
1               5                   10                  15      


Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys 
            20                  25                  30          


Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr 
        35                  40                  45              


Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu 
    50                  55                  60                  


Lys Val Phe Asp Val Ile 
65                  70  


<210>  78
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  78

Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser 
1               5                   10                  15      


Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala 
            20                  25                  30          


Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro 
        35                  40                  45              


Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys 
    50                  55                  60                  


Val Phe Asp Val Ile 
65                  


<210>  79
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  79

Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
1               5                   10                  15      


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            20                  25                  30          


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        35                  40                  45              


Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
    50                  55                  60                  


Phe Asp Val Ile 
65              


<210>  80
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  80

Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu 
1               5                   10                  15      


Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
            20                  25                  30          


Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
        35                  40                  45              


Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
    50                  55                  60                  


Asp Val Ile 
65          


<210>  81
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  81

Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu 
1               5                   10                  15      


Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly 
            20                  25                  30          


Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr 
        35                  40                  45              


Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp 
    50                  55                  60                  


Val Ile 
65      


<210>  82
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  82

Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
1               5                   10                  15      


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
            20                  25                  30          


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
        35                  40                  45              


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60                  


<210>  83
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  83

Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
1               5                   10                  15      


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
            20                  25                  30          


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
        35                  40                  45              


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60              


<210>  84
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  84

Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu 
1               5                   10                  15      


Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
            20                  25                  30          


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser 
        35                  40                  45              


Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60          


<210>  85
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  85

Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val 
1               5                   10                  15      


Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys 
            20                  25                  30          


Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro 
        35                  40                  45              


Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60      


<210>  86
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  86

Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala 
1               5                   10                  15      


Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln 
            20                  25                  30          


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg 
        35                  40                  45              


Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60  


<210>  87
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  87

Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys 
1               5                   10                  15      


Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys 
            20                  25                  30          


Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
        35                  40                  45              


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  


<210>  88
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu 
1               5                   10                  15      


Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe 
            20                  25                  30          


Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met 
        35                  40                  45              


Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55              


<210>  89
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  89

Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu 
1               5                   10                  15      


Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
            20                  25                  30          


Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala 
        35                  40                  45              


Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55          


<210>  90
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  90

Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys 
1               5                   10                  15      


Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu 
            20                  25                  30          


Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val 
        35                  40                  45              


Arg Glu Lys Val Phe Asp Val Ile 
    50                  55      


<210>  91
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  91

Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu 
1               5                   10                  15      


Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys 
            20                  25                  30          


Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg 
        35                  40                  45              


Glu Lys Val Phe Asp Val Ile 
    50                  55  


<210>  92
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  92

Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys 
1               5                   10                  15      


Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr 
            20                  25                  30          


Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu 
        35                  40                  45              


Lys Val Phe Asp Val Ile 
    50                  


<210>  93
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  93

Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala 
1               5                   10                  15      


Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys 
        35                  40                  45              


Val Phe Asp Val Ile 
    50              


<210>  94
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  94

Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
1               5                   10                  15      


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
            20                  25                  30          


Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
        35                  40                  45              


Phe Asp Val Ile 
    50          


<210>  95
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  95

Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
1               5                   10                  15      


Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
            20                  25                  30          


Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
        35                  40                  45              


Asp Val Ile 
    50      


<210>  96
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  96

Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly 
1               5                   10                  15      


Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr 
            20                  25                  30          


Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp 
        35                  40                  45              


Val Ile 
    50  


<210>  97
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  97

Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
1               5                   10                  15      


Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg 
            20                  25                  30          


Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val 
        35                  40                  45              


Ile 
    


<210>  98
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  98

Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
1               5                   10                  15      


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
            20                  25                  30          


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45              


<210>  99
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  99

Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
1               5                   10                  15      


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
            20                  25                  30          


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45          


<210>  100
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  100

Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
1               5                   10                  15      


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser 
            20                  25                  30          


Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45      


<210>  101
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  101

Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys 
1               5                   10                  15      


Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro 
            20                  25                  30          


Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45  


<210>  102
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  102

Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln 
1               5                   10                  15      


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg 
            20                  25                  30          


Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  


<210>  103
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  103

Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys 
1               5                   10                  15      


Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
            20                  25                  30          


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40              


<210>  104
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  104

Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe 
1               5                   10                  15      


Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met 
            20                  25                  30          


Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40          


<210>  105
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  105

Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
1               5                   10                  15      


Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala 
            20                  25                  30          


Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40      


<210>  106
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  106

Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu 
1               5                   10                  15      


Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val 
            20                  25                  30          


Arg Glu Lys Val Phe Asp Val Ile 
        35                  40  


<210>  107
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS-Fc fusion protein (C-terminal Fc fusion)

<400>  107

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    50                  55                  60                  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
65                  70                  75                  80  


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                85                  90                  95      


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            100                 105                 110         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        115                 120                 125             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    130                 135                 140                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
145                 150                 155                 160 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                165                 170                 175     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            180                 185                 190         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        195                 200                 205             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    210                 215                 220                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
225                 230                 235                 240 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                245                 250                 255     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Lys 
        275 


<210>  108
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS-Fc fusion protein (N-terminal Fc fusion)

<400>  108

Met Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu 
225                 230                 235                 240 


Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu 
                245                 250                 255     


Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
            260                 265                 270         


Gly Pro Asp 
        275 


<210>  109
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS-Fc fusion protein (C-terminal Fc fusion)

<400>  109

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Asp Lys Thr His Thr Cys 
            500                 505                 510         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        515                 520                 525             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    530                 535                 540                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
545                 550                 555                 560 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                565                 570                 575     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            580                 585                 590         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        595                 600                 605             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    610                 615                 620                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
625                 630                 635                 640 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                645                 650                 655     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            660                 665                 670         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        675                 680                 685             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    690                 695                 700                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
705                 710                 715                 720 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730             


<210>  110
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS-Fc fusion protein (N-terminal Fc fusion)

<400>  110

Met Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu 
225                 230                 235                 240 


Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu 
                245                 250                 255     


Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
            260                 265                 270         


Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
        275                 280                 285             


Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
    290                 295                 300                 


Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp 
305                 310                 315                 320 


Thr Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu 
                325                 330                 335     


Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu 
            340                 345                 350         


Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met 
        355                 360                 365             


Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg 
    370                 375                 380                 


Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln 
385                 390                 395                 400 


Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala 
                405                 410                 415     


Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly 
            420                 425                 430         


Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe 
        435                 440                 445             


Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser 
    450                 455                 460                 


Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met 
465                 470                 475                 480 


Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp 
                485                 490                 495     


Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln 
            500                 505                 510         


Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp 
        515                 520                 525             


Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys 
    530                 535                 540                 


Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly 
545                 550                 555                 560 


Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu 
                565                 570                 575     


Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly 
            580                 585                 590         


Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly 
        595                 600                 605             


Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu 
    610                 615                 620                 


Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val 
625                 630                 635                 640 


Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser 
                645                 650                 655     


Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn 
            660                 665                 670         


Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro 
        675                 680                 685             


Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys 
    690                 695                 700                 


Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp 
705                 710                 715                 720 


Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
                725                 730             


<210>  111
<211>  1527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  111
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag      180

ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc      240

atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag      300

gaaacactga tgggaaagta tggggaagac tccaagctta tctatgacct gaaggaccag      360

ggcggggagc tcctgtccct tcgctatgac ctcactgttc cttttgctcg gtatttggca      420

atgaataaac tgaccaacat taaacgctac cacatagcaa aggtatatcg gcgggataac      480

ccagccatga cccgtggccg ataccgggaa ttctaccagt gtgattttga cattgctggg      540

aactttgatc ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga gatcctgagt      600

tcacttcaga taggcgactt cctggtcaag gtaaacgatc gacgcattct agatgggatg      660

tttgctatct gtggtgtttc tgacagcaag ttccgtacca tctgctcctc agtagacaag      720

ctggacaagg tgtcctggga agaggtgaag aatgagatgg tgggagagaa gggccttgca      780

cctgaggtgg ctgaccgcat tggggactat gtccagcaac atggtggggt atccctggtg      840

gaacagctgc tccaggatcc taaactatcc caaaacaagc aggccttgga gggcctggga      900

gacctgaagt tgctctttga gtacctgacc ctatttggca ttgatgacaa aatctccttt      960

gacctgagcc ttgctcgagg gctggattac tacactgggg tgatctatga ggcagtgctg     1020

ctacagaccc cagcccaggc aggggaagag cccctgggtg tgggcagtgt ggctgctgga     1080

ggacgctatg atgggctagt gggcatgttc gaccccaaag ggcgcaaggt gccatgtgtg     1140

gggctcagca ttggggtgga gcggattttc tccatcgtgg aacagagact agaggctttg     1200

gaggagaaga tacggaccac ggagacacag gtgcttgtgg catctgcaca gaagaagctg     1260

ctagaggaaa gactaaagct tgtctcagaa ctgtgggatg ctgggatcaa ggctgagctg     1320

ctgtacaaga agaacccaaa gctactgaac cagttacagt actgtgagga ggcaggcatc     1380

ccactggtgg ctatcatcgg cgagcaggaa ctcaaggatg gggtcatcaa gctccgttca     1440

gtgacgagca gggaagaggt ggatgtccga agagaagacc ttgtggagga aatcaaaagg     1500

agaacaggcc agcccctctg catctgc                                         1527


<210>  112
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  112
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaacccgtg actattctcc tcgtcaaatg gccgtccgtg aaaaagtgtt cgacgtgatc      240

attcgctgct ttaaacgcca tggtgccgaa gtgattgata ccccggtgtt tgagctgaaa      300

gagacactga tgggcaaata tggtgaggac agcaaactga tttatgacct gaaagatcag      360

ggtggtgaac tgctgagtct gcgctatgat ctgacagttc cgtttgcccg ttatctggca      420

atg                                                                    423


<210>  113
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  113
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaacccgtg actattctcc tcgtcaaatg gccgtccgtg aaaaagtgtt cgacgtgatc      240

attcgctgct ttaaacgcca tggtgccgaa gtgattgata ccccggtgtt tgagctgaaa      300

gagacactga tgggcaaata tggtgaggac agcaaactga tttatgacct gaaagatcag      360

ggtggtgaac tgctgagtct gcgctatgat ctgacagttc cgtttgcccg ttatctggca      420

atgaataaac tgaccaacat taaacgctat cacattgcta aagtctatcg ccgtgacaat      480

cctgctatga cccgtggtcg ttatcgtgag ttctatcagt gtgacttcga tattgccggc      540

aactttgatc cgatgatccc ggatgctgaa tgcctgaaaa tcatgtgtga gatcctgagc      600

agtctgcaga ttggcgattt cctggtgaaa gtcaacgatc gccgtattct ggatggcatg      660

ttcgccatct gtggtgttag cgactccaaa ttccgtacca tctgtagtag tgtggacaaa      720

ctggataaag tgagctggga ggaggtgaaa aacgaaatgg tgggcgagaa aggtctggct      780

cctgaagtgg ctgaccgtat tggtgattat gtccagcagc acggtggagt atcactggtt      840

gagcaactgc tgcaagaccc taaactgagt cagaataaac aggccctgga gggactggga      900

gatctgaaac tgctgttcga gtatctgacc ctgttcggta tcgatgacaa aatctccttt      960

gacctgtcac tggctcgtgg actggactat tataccggcg tgatctatga agctgtactg     1020

ctgcaaactc cagcacaagc aggtgaagag cctctgggtg tgggtagtgt agccgctggg     1080

ggacgttatg atggactggt ggggatgttc gaccctaaag gccgtaaagt tccgtgtgtg     1140

ggtctgagta tcggtgttga gcgtatcttt tccatcgtcg agcaacgtct ggaagcactg     1200

gaggaaaaaa tccgtacgac cgaa                                            1224


<210>  114
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  114
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaacccgtg actattctcc tcgtcaaatg gccgtccgtg aaaaagtgtt cgacgtgatc      240

attcgctgct ttaaacgcca tggtgccgaa gtgattgata ccccggtgtt tgagctgaaa      300

gagacactga tgggcaaata tggtgaggac agcaaactg                             339


<210>  115
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  115
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaag      180


<210>  116
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  116
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag      180

ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc      240

atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag      300

gaaacactga tgggaaagta tggggaagac tccaagctta tctatgacct gaaggaccag      360

ggcggggagc tcctgtccct tcgctatgac ctcactgttc cttttgctcg gtatttggca      420

atgaataaac tgaccaacat taaacgctac cacatagcaa aggtatatcg gcgggataac      480

ccagccatga cccgtggccg ataccgggaa ttctaccagt gtgattttga cattgctggg      540

aactttgatc ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga gatcctgagt      600

tcacttcaga taggcgactt cctggtcaag gtaaacgatc gacgcattct agatgggatg      660

tttgctatct gtggtgtttc tgacagcaag ttccgtacca tctgctcctc agtagacaag      720

ctggacaagg tgtcctggga agaggtgaag aatgagatgg tgggagagaa gggccttgca      780

cctgaggtgg ctgaccgcat tggggactat gtccagcaac atggtggggt atccctggtg      840

gaacagctgc tccaggatcc taaactatcc caaaacaagc aggccttgga gggcctggga      900

gacctgaagt tgctctttga gtacctgacc ctatttggca ttgatgacaa aatctccttt      960

gacctgagcc ttgctcgagg gctggattac tacactgggg tgatctatga ggcagtgctg     1020

ctacagaccc cagcccaggc aggggaagag cccctgggtg tgggcagtgt ggctgctgga     1080

ggacgctatg atgggctagt gggcatgttc gaccccaaag ggcgcaaggt gccatgtgtg     1140

gggctcagca ttggggtgga gcggattttc tccatcgtgg aacagagact agaggctttg     1200

gaggagaaga tacggaccac ggagacacag gtgcttgtgg catctgcaca gaagaagctg     1260

ctagaggaaa gactaaagct tgtctcagaa ctgtgggatg ctgggatcaa ggctgagctg     1320

ctgtacaaga agaacccaaa gctactgaac cagttacagt actgtgagga ggcaggcatc     1380

ccactggtgg ctatcatcgg cgagcaggaa ctcaaggatg gggtcatcaa gctccgttca     1440

gtgacgagca gggaagaggt ggatgtccga agagaagacc ttgtggagga aatcaaaagg     1500

agaacaggcc agcccctc                                                   1518


<210>  117
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized version of HRS

<400>  117
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgat                                             144


<210>  118
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  118
tgcctgaaaa tcatgtgtga gatcctgagt agtctgcaaa ttggcgactt tctggtcaaa       60

gtgaacgatc gccgtattct ggatggcatg ttcgccatct gtggtgttag cgactccaaa      120

ttccgtacaa tctgtagcag cgtggacaaa ctggataaag tgtcctggga agaggtgaaa      180

aacgaaatgg tgggtgaaaa aggtctggct ccggaggttg ctgaccgtat cggtgattat      240

gttcagcagc acggcggtgt tagtctggtt gaacaactgc tgcaagaccc gaaactgtct      300

cagaacaaac aggccctgga aggactggga gatctgaaac tgctgttcga gtatctgacg      360

ctgttcggca ttgatgacaa aatttctttc gacctgtcac tggcacgtgg actggactat      420

tataccggt                                                              429


<210>  119
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  119
cgtaccaccg aaacccaagt tctggttgcc tcagctcaga aaaaactgct ggaagaacgc       60

ctgaaactgg ttagcgaact gtgggatgct ggcattaaag ccgaactgct gtataaaaaa      120

aacccgaaac tgctgaatca gctgcagtat tgtgaggaag cgggtattcc tctggtggcc      180

attatcggag aacaggaact gaaagacggc gttattaaac tgcgtagcgt gacctctcgt      240

gaagaagttg acgttcgccg tgaagatctg gtcgaggaaa tcaaacgtcg taccggtcaa      300

cctctgtgta tttgc                                                       315


<210>  120
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  120
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaacccgtg actattctcc tcgtcaaatg gccgtccgtg aaaaagtgtt cgacgtgatc      240

attcgctgct ttaaacgcca tggtgccgaa gtgattgata ccccggtgtt tgagctgaaa      300

gagacactga tgggcaaata tggtgaggac agcaaactga tctatgacct gaaagaccaa      360

ggcggtgaac tgctgtccct gcgttatgat ctgactgtgc cgtttgcccg ttatctggcc      420

atgaataaac tgacgaacat taaacgctat cacattgcca aagtgtatcg ccgtgacaat      480

cctgctatga ctcgtggacg ttatcgtgaa ttctatcagt gtgacttcga tattgccggc      540

aacttcgacc ctatgattcc ggatgctgaa tgcctgaaaa tcatgtgtga gatcctgagc      600

agcctgcaaa ttggtgactt cctggtgaaa gtgaatgacc gtcgtatcct ggatggcatg      660

tttgccattt gtggtgtgag cgattccaaa ttccgtacca tctgtagtag tgtggacaaa      720

ctggataaag tgggctatcc gtggtggaac tcttgtagcc gtattctgaa ctatcctaaa      780

accagccgcc cgtggcgtgc ttgggaaact                                       810


<210>  121
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  121
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

gacttcgata ttgccgggaa ttttgaccct atgatccctg atgccgaatg tctgaaaatc      240

atgtgtgaga tcctgagcag tctgcagatt ggtgacttcc tggtgaaagt gaacgatcgc      300

cgtattctgg atggaatgtt tgccatttgt ggcgtgtctg acagcaaatt tcgtacgatc      360

tgtagcagcg tggataaact ggataaagtg agctgggagg aggtgaaaaa tgagatggtg      420

ggcgaaaaag gtctggcacc tgaagtggct gaccgtatcg gtgattatgt tcagcaacat      480

ggcggtgttt ctctggtcga acagctgctg caagacccaa aactgagcca gaacaaacag      540

gcactggaag gactgggtga tctgaaactg ctgtttgagt atctgacgct gtttggcatc      600

gatgacaaaa tctcgtttga cctgagcctg gcacgtggtc tggattatta taccggcgtg      660

atctatgaag ccgtcctgct gcaaactcca gcacaagcag gtgaagaacc tctgggtgtt      720

ggtagtgtag cggcaggcgg acgttatgat ggactggtgg ggatgtttga tccgaaaggc      780

cgtaaagttc cgtgtgtcgg tctgagtatc ggggttgagc gtatctttag cattgtggag      840

caacgtctgg aagctctgga ggaaaaaatc cgtaccaccg aaacccaagt tctggttgcc      900

tcagctcaga aaaaactgct ggaagaacgc ctgaaactgg ttagcgaact gtgggatgct      960

ggcattaaag ccgaactgct gtataaaaaa aacccgaaac tgctgaatca gctgcagtat     1020

tgtgaggaag cgggtattcc tctggtggcc attatcggag aacaggaact gaaagacggc     1080

gttattaaac tgcgtagcgt gacctctcgt gaagaagttg acgttcgccg tgaagatctg     1140

gtcgaggaaa tcaaacgtcg taccggtcaa cctctgtgta tttgc                     1185


<210>  122
<211>  1077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  122
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

gtgaatgatc gccgtatcct ggatggcatg tttgccattt gtggtgtgag cgactcgaaa      240

ttccgtacga tttgctctag cgtcgataaa ctggacaaag tgtcctggga agaggtgaaa      300

aacgagatgg tgggtgagaa aggtctggct cctgaagttg ccgaccgtat tggtgattat      360

gttcagcagc atggcggtgt ttcactggtt gaacaactgc tgcaagaccc gaaactgtct      420

cagaataaac aggcgctgga aggactggga gatctgaaac tgctgtttga gtatctgacc      480

ctgttcggca ttgatgacaa aatcagcttc gacctgagcc tggcacgtgg tctggattat      540

tataccggcg tgatctatga agccgttctg ctgcagacac cagcacaagc aggcgaagaa      600

cctctgggtg ttggttctgt ggcagccggt ggtcgttatg atggactggt aggcatgttc      660

gatccgaaag gccgtaaagt tccgtgtgtg ggactgagta tcggtgttga gcgtatcttt      720

agcatcgtgg aacaacgtct ggaagcgctg gaggagaaaa ttcgtaccac cgaaacccaa      780

gttctggttg cctcagctca gaaaaaactg ctggaagaac gcctgaaact ggttagcgaa      840

ctgtgggatg ctggcattaa agccgaactg ctgtataaaa aaaacccgaa actgctgaat      900

cagctgcagt attgtgagga agcgggtatt cctctggtgg ccattatcgg agaacaggaa      960

ctgaaagacg gcgttattaa actgcgtagc gtgacctctc gtgaagaagt tgacgttcgc     1020

cgtgaagatc tggtcgagga aatcaaacgt cgtaccggtc aacctctgtg tatttgc        1077


<210>  123
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  123
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaactcgtg attatagccc tcgccagatg gctgtccgtg aaaaagtgtt cgatgtgatc      240

attcgctgct tcaaacgtca tggtgccgaa gtcattgata ccccggtgtt cgagctgaaa      300

gtgaacgatc gccgtattct ggatggcatg ttcgccattt gtggtgttag cgatagcaaa      360

ttccgtacaa tctgctctag cgtggacaaa ctggacaaag tgagctggga agaggtgaaa      420

aacgagatgg tgggtgagaa aggcctggct cctgaagttg ccgaccgtat cggagattat      480

gttcagcagc atggcggagt ttcactggtt gaacaactgc tgcaagaccc gaaactgtct      540

cagaacaaac aggcactgga aggtctggga gatctgaaac tgctgttcga gtatctgacg      600

ctgttcggta ttgacgacaa aatttccttc gacctgtcgc tggcacgtgg tctggattat      660

tatacaggcg tgatctatga ggctgtactg ctgcagacac cagcacaagc aggtgaagag      720

cctctgggtg ttggttcagt tgctgccggt ggacgttatg acggactggt agggatgttt      780

gacccaaaag gccgtaaagt cccgtgtgta ggactgtcta ttggcgttga gcgtatcttt      840

agcatcgtgg agcaacgtct ggaagctctg gaggagaaaa tccgtaccac cgaaacccaa      900

gttctggttg cctcagctca gaaaaaactg ctggaagaac gcctgaaact ggttagcgaa      960

ctgtgggatg ctggcattaa agccgaactg ctgtataaaa aaaacccgaa actgctgaat     1020

cagctgcagt attgtgagga agcgggtatt cctctggtgg ccattatcgg agaacaggaa     1080

ctgaaagacg gcgttattaa actgcgtagc gtgacctctc gtgaagaagt tgacgttcgc     1140

cgtgaagatc tggtcgagga aatcaaacgt cgtaccggtc aacctctgtg tatttgc        1197


<210>  124
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  124
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaactcgtg attatagccc tcgccagatg gctgtccgtg aaaaagtgtt cgatgtgatc      240

attcgctgct tcaaacgtca tggtgccgaa gtcattgata ccccggtgtt cgagctgaaa      300

gaaaccctga tgggcaaata tggggaagat tccaaactga tctatgacct gaaagaccag      360

ggaggtgaac tgctgtctct gcgctatgac ctgactgttc cttttgctcg ctatctggcc      420

atgaataaac tgaccaacat caaacgctat catatcgcca aagtgtatcg ccgtgacaat      480

ccagcaatga cccgtggtcg ttatcgtgaa ttttatcagt gtgtgaacga tcgccgtatt      540

ctggacggca tgttcgccat ttgtggtgtg tctgactcca aatttcgtac gatctgctca      600

agcgtggaca aactggacaa agtgagctgg gaagaggtga aaaacgagat ggtgggtgag      660

aaaggcctgg ctcctgaagt tgccgaccgt atcggagatt atgttcagca gcatggcgga      720

gtttcactgg ttgaacaact gctgcaagac ccgaaactgt cacagaacaa acaggcactg      780

gaaggtctgg gggatctgaa actgctgttc gagtatctga cgctgttcgg tattgacgac      840

aaaatcagct tcgatctgag cctggcacgt ggtctggact attataccgg cgtgatttat      900

gaagccgttc tgctgcagac tccagcacaa gcaggtgaag agcctctggg tgttggaagt      960

gtggcagccg gtggccgtta tgatggtctg gttggcatgt ttgacccgaa aggccgtaaa     1020

gtcccgtgtg taggactgtc tatcggcgtg gagcgtattt ttagcatcgt ggaacaacgc     1080

ctggaagctc tggaagagaa aatccgtacc accgaaaccc aagttctggt tgcctcagct     1140

cagaaaaaac tgctggaaga acgcctgaaa ctggttagcg aactgtggga tgctggcatt     1200

aaagccgaac tgctgtataa aaaaaacccg aaactgctga atcagctgca gtattgtgag     1260

gaagcgggta ttcctctggt ggccattatc ggagaacagg aactgaaaga cggcgttatt     1320

aaactgcgta gcgtgacctc tcgtgaagaa gttgacgttc gccgtgaaga tctggtcgag     1380

gaaatcaaac gtcgtaccgg tcaacctctg tgtatttgc                            1419


<210>  125
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  125
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

gaaaccctga tgggcaaata tggcgaagat tccaaactga tctatgacct gaaagaccaa      240

ggcggtgaac tgctgtccct gcgttatgac ctgactgttc cgtttgctcg ttatctggcc      300

atgaataaac tgaccaacat taaacgctat cacattgcca aagtgtatcg ccgtgacaat      360

cctgctatga ctcgtggacg ttatcgtgaa ttctatcagt gtgacttcga tattgccggc      420

aacttcgacc ctatgattcc ggatgctgaa tgcctgaaaa tcatgtgtga gatcctgagc      480

agcctgcaaa ttggtgactt cctggtgaaa gtgaatgacc gtcgtatcct ggatggcatg      540

ttcgccattt gtggtgttag cgattccaaa ttccgtacca tctgtagtag tgtggacaaa      600

ctggataaag tgagctggga agaggtgaaa aacgaaatgg tgggcgaaaa aggtctggca      660

cctgaggttg ctgatcgtat cggtgactat gtccagcagc atggaggtgt ttcactggtt      720

gagcaactgc tgcaagatcc gaaactgtct cagaacaaac aggccctgga aggactgggt      780

gatctgaaac tgctgttcga gtatctgacg ctgttcggta ttgatgacaa aatctcgttc      840

gacctgtctc tggctcgtgg actggattat tatacgggcg taatctatga agctgtcctg      900

ctgcagacac cagcacaagc aggtgaagag cctctgggtg ttggaagtgt tgctgccggt      960

ggtcgctatg acggactggt tggcatgttc gatccgaaag gccgtaaagt tccgtgtgta     1020

ggactgagca ttggcgttga gcgtatcttt tccatcgttg agcaacgtct ggaagcactg     1080

gaagagaaaa tccgtaccac cgaaacccaa gttctggttg cctcagctca gaaaaaactg     1140

ctggaagaac gcctgaaact ggttagcgaa ctgtgggatg ctggcattaa agccgaactg     1200

ctgtataaaa aaaacccgaa actgctgaat cagctgcagt attgtgagga agcgggtatt     1260

cctctggtgg ccattatcgg agaacaggaa ctgaaagacg gcgttattaa actgcgtagc     1320

gtgacctctc gtgaagaagt tgacgttcgc cgtgaagatc tggtcgagga aatcaaacgt     1380

cgtaccggtc aacctctgtg tatttgc                                         1407


<210>  126
<211>  1305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  126
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaactcgtg attatagccc tcgccagatg gctgtccgtg aaaaagtgtt cgatgtgatc      240

attcgctgct tcaaacgtca tggtgccgaa gtcattgata ccccggtgtt cgagctgaaa      300

gatttcgata ttgccggcaa ctttgatccg atgattccgg atgctgagtg tctgaaaatc      360

atgtgtgaga tcctgagtag tctgcagatt ggggatttcc tggtgaaagt gaacgatcgc      420

cgtattctgg acggcatgtt tgccatttgt ggcgttagcg atagcaaatt ccgtacgatc      480

tgtagcagtg tggacaaact ggataaagtc tcttgggaag aggtcaaaaa cgagatggtt      540

ggtgagaaag gcctggctcc tgaagtggct gaccgtattg gtgattatgt ccagcagcat      600

ggtggtgttt cactggttga acaactgctg caagacccga aactgtctca gaacaaacag      660

gcactggaag gtctgggtga tctgaaactg ctgttcgagt atctgacgct gttcggtatt      720

gacgacaaaa tttccttcga cctgtcactg gcacgtggtc tggattatta tacaggcgta      780

atctatgagg ctgtactgct gcaaactcca gcacaagcag gtgaagaacc tctgggagtt      840

ggtagtgtag cggcaggggg tcgttatgat gggctggtcg ggatgttcga tccaaaaggc      900

cgtaaagtcc cgtgtgttgg tctgtctatt ggcgttgagc gtatcttctc catcgtggag      960

caacgtctgg aagctctgga agaaaaaatc cgtaccaccg aaacccaagt tctggttgcc     1020

tcagctcaga aaaaactgct ggaagaacgc ctgaaactgg ttagcgaact gtgggatgct     1080

ggcattaaag ccgaactgct gtataaaaaa aacccgaaac tgctgaatca gctgcagtat     1140

tgtgaggaag cgggtattcc tctggtggcc attatcggag aacaggaact gaaagacggc     1200

gttattaaac tgcgtagcgt gacctctcgt gaagaagttg acgttcgccg tgaagatctg     1260

gtcgaggaaa tcaaacgtcg taccggtcaa cctctgtgta tttgc                     1305


<210>  127
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of HRS

<400>  127
atgttcgacc caaaaggccg taaagttccg tgtgtagggc tgtctatcgg tgttgagcgt       60

atcttctcca tcgttgagca gcgtctggaa gcactggagg aaaaaatccg tacgaccgag      120

actcaagtcc tggttgctag tgcccagaaa aaactgctgg aagagcgcct gaaactggtt      180

agtgagctgt gggatgccgg tattaaagcc gaactgctgt ataaaaaaaa cccgaaactg      240

ctgaatcagc tgcagtattg tgaagaagcg ggcattccgc tggtagcgat tatcggggaa      300

caagaactga aagatggcgt gatcaaactg cgtagcgtta caagccgtga ggaagtggac      360

gtccgccgtg aggatctggt tgaagagatt aaacgccgta caggtcagcc tctgtgtatt      420

tgc                                                                    423


<210>  128
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Human IgA1 hinge region

<400>  128

Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  129
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  Human IgA1 CH2 region

<400>  129

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Thr Leu Ser Lys Ser 
            100     


<210>  130
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  human IgA1 CH3 region

<400>  130

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  131
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  human IgA2 hinge region

<400>  131

Val Pro Pro Pro Pro Pro 
1               5       


<210>  132
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  human IgA2 CH2

<400>  132

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Asn Ile Thr Lys Ser 
            100     


<210>  133
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  human IgA2 CH3 region

<400>  133

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  134
<211>  58
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(58)
<223>  human IgD hinge region

<400>  134

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  135
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  human IgD CH2 region

<400>  135

Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro 
1               5                   10                  15      


Ala Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe 
            20                  25                  30          


Val Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala 
        35                  40                  45              


Gly Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His 
    50                  55                  60                  


Ser Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser 
65                  70                  75                  80  


Leu Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser 
                85                  90                  95      


Leu Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro 
            100                 105             


<210>  136
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(117)
<223>  human IgD CH3 region

<400>  136

Ala Ala Gln Ala Pro Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser 
1               5                   10                  15      


Asp Pro Pro Glu Ala Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe 
            20                  25                  30          


Ser Pro Pro Asn Ile Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val 
        35                  40                  45              


Asn Thr Ser Gly Phe Ala Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser 
    50                  55                  60                  


Thr Thr Phe Trp Ala Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser 
65                  70                  75                  80  


Pro Gln Pro Ala Thr Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg 
                85                  90                  95      


Thr Leu Leu Asn Ala Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp 
            100                 105                 110         


His Gly Pro Met Lys 
        115         


<210>  137
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  human IgE CH2 region

<400>  137

Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
1               5                   10                  15      


Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
            20                  25                  30          


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
        35                  40                  45              


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
    50                  55                  60                  


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
65                  70                  75                  80  


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala 
            100                 105         


<210>  138
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  human IgE CH3 region

<400>  138

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105             


<210>  139
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  human IgE CH4 region

<400>  139

Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
1               5                   10                  15      


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
            20                  25                  30          


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
        35                  40                  45              


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
    50                  55                  60                  


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
65                  70                  75                  80  


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
                85                  90                  95      


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
            100                 105                 110 


<210>  140
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  human IgG1 hinge region

<400>  140

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  141
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  human IgG1 CH2 region

<400>  141

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  142
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  human IgG1 CH3 region

<400>  142

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  143
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  human IgG2 hinge region

<400>  143

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  144
<211>  109
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(109)
<223>  human IgG2 CH2 region

<400>  144

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 


<210>  145
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  human IgG2 CH3 region

<400>  145

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  146
<211>  62
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(62)
<223>  human IgG3 hinge region

<400>  146

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  147
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  human IgG3 CH2 region

<400>  147

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 110 


<210>  148
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  human IgG3 CH3 region

<400>  148

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  149
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  human IgG4 hinge region

<400>  149

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  150
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  human IgG4 CH2 region

<400>  150

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  151
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  human IgG4 CH3 region

<400>  151

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  152
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(112)
<223>  human IgM CH2 region

<400>  152

Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg 
1               5                   10                  15      


Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala 
            20                  25                  30          


Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly 
        35                  40                  45              


Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala 
    50                  55                  60                  


Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile 
65                  70                  75                  80  


Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp 
                85                  90                  95      


His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro 
            100                 105                 110         


<210>  153
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  human IgM CH3 region

<400>  153

Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala 
1               5                   10                  15      


Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp 
            20                  25                  30          


Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly 
        35                  40                  45              


Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala 
    50                  55                  60                  


Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn 
65                  70                  75                  80  


Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser 
                85                  90                  95      


Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys 
            100                 105     


<210>  154
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  human IgM CH4 region

<400>  154

Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg 
1               5                   10                  15      


Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr 
            20                  25                  30          


Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln 
        35                  40                  45              


Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro 
    50                  55                  60                  


Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu 
65                  70                  75                  80  


Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu 
                85                  90                  95      


Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly 
            100                 105                 110         


Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  155
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc variant


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Ala or absent

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa is Pro or Glu

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa is Phe, Val or Ala

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa is Leu, Glu or Ala

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Xaa is Asn or Ala

<220>
<221>  VARIANT
<222>  (230)..(230)
<223>  Xaa is Lys or absent

<400>  155

Xaa Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Xaa 
1               5                   10                  15      


Xaa Xaa Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Xaa 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            100                 105                 110         


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Leu Gly Xaa 
225                 230 


<210>  156
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  156

Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu 
1               5                   10                  15      


Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp 
            20                  25                  30          


Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala 
        35                  40                  45              


Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser 
    50                  55                  60                  


Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr Phe 
65                  70                  75                  80  


Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr 
                85                  90                  95      


Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro 
            100                 105                 110         


Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys 
        115                 120                 125             


Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln 
    130                 135                 140                 


Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg 
145                 150                 155                 160 


Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu 
                165                 170                 175     


Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met 
            180                 185                 190         


Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp 
        195                 200                 205             


Arg 
    


<210>  157
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  157

Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu 
1               5                   10                  15      


Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp 
            20                  25                  30          


Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala 
        35                  40                  45              


Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser 
    50                  55                  60                  


Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe 
65                  70                  75                  80  


Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn 
                85                  90                  95      


Ile Thr Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro 
            100                 105                 110         


Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys 
        115                 120                 125             


Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln 
    130                 135                 140                 


Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg 
145                 150                 155                 160 


Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu 
                165                 170                 175     


Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met 
            180                 185                 190         


Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp 
        195                 200                 205             


Arg 
    


<210>  158
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  158

Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe 
1               5                   10                  15      


Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr 
            20                  25                  30          


Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val 
        35                  40                  45              


Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser 
    50                  55                  60                  


Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu 
65                  70                  75                  80  


Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys 
                85                  90                  95      


Gln Thr Ile Ser Arg Pro Lys Gly Val Ala Leu His Arg Pro Asp Val 
            100                 105                 110         


Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala 
        115                 120                 125             


Thr Ile Thr Cys Leu Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val 
    130                 135                 140                 


Gln Trp Met Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr 
145                 150                 155                 160 


Ser Ala Pro Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His 
                165                 170                 175     


Ser Ile Leu Thr Val Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr 
            180                 185                 190         


Thr Cys Val Val Ala His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg 
        195                 200                 205             


Thr Val Asp Lys 
    210         


<210>  159
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  159

Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu 
        35                  40                  45              


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
                85                  90                  95      


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        115                 120                 125             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    130                 135                 140                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
145                 150                 155                 160 


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                165                 170                 175     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            180                 185                 190         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        195                 200                 205             


<210>  160
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  160

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        115                 120                 125             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    130                 135                 140                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
145                 150                 155                 160 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                165                 170                 175     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            180                 185                 190         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        195                 200                 205             


<210>  161
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  161

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        115                 120                 125             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    130                 135                 140                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
145                 150                 155                 160 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                165                 170                 175     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            180                 185                 190         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        195                 200                 205             


<210>  162
<211>  208
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (90)..(90)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (103)..(103)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (105)..(105)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (181)..(181)
<223>  Xaa = any amino acid

<400>  162

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Xaa 
65                  70                  75                  80  


Gly Lys Glu Tyr Lys Cys Lys Val Ser Xaa Lys Gly Leu Pro Ser Ser 
                85                  90                  95      


Ile Glu Lys Thr Ile Ser Xaa Ala Xaa Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        115                 120                 125             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    130                 135                 140                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
145                 150                 155                 160 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                165                 170                 175     


Val Asp Lys Ser Xaa Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            180                 185                 190         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        195                 200                 205             


<210>  163
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  163

Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe 
1               5                   10                  15      


Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro 
            20                  25                  30          


Ser Lys Gly Thr Val Gln Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro 
        35                  40                  45              


Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu 
    50                  55                  60                  


Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly 
65                  70                  75                  80  


Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu 
                85                  90                  95      


Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val 
            100                 105                 110         


Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr 
        115                 120                 125             


Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln 
    130                 135                 140                 


Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr 
145                 150                 155                 160 


Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu 
                165                 170                 175     


Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg 
            180                 185                 190         


Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val 
        195                 200                 205             


Ser Val 
    210 


<210>  164
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  164
aaacaaaaca aaaca                                                        15


<210>  165
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  165
aaacaaaaca                                                              10


<210>  166
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  166
caaaacaaaa                                                              10


<210>  167
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  167
caaaacaaaa caaaa                                                        15


<210>  168
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  168
aaacaaaaca                                                              10


<210>  169
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  169
acaaaacaaa                                                              10


<210>  170
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg 
            500 


<210>  171
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg 
            500     


<210>  172
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr 
            500         


<210>  173
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly 
            500             


<210>  174
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln 
            500                 


<210>  175
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro 
            500                 505 


<210>  176
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys 
            500                 505         


<210>  177
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile 
            500                 505             


<210>  178
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  179
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HRS polypeptide

<400>  179

Met Cys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly 
1               5                   10                  15      


Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile 
            20                  25                  30          


Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
        35                  40                  45              


Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60      


<210>  180
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HRS polypeptide

<400>  180

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Cys Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  181
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HRS polypeptide

<400>  181

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Cys 
    50                  55                  60      


<210>  182
<211>  183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cyteine modified HRS

<400>  182
atgtgtgcag aaagagccgc cctggaagag ttagttaagt tgcaaggtga acgtgtccgt       60

ggtctgaagc agcagaaggc tagcgcggag ctgatcgaag aagaggtggc caaactgctg      120

aagctgaagg cgcagctggg cccggacgag agcaaacaaa agttcgtcct gaaaaccccg      180

aaa                                                                    183


<210>  183
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cyteine modified HRS

<400>  183
atggcagaac gtgcggcatt ggaagaattg gttaaactgc aaggtgaacg tgttcgtggt       60

ctgaagcagc agaagtgcag cgcggagctg atcgaagaag aggtggccaa actgctgaag      120

ctgaaggcgc agctgggccc ggacgagagc aaacaaaagt tcgtcctgaa aaccccgaaa      180


<210>  184
<211>  183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cyteine modified HRS

<400>  184
atggcagaac gtgcggcatt ggaagaattg gttaaactgc aaggtgaacg tgttcgtggt       60

ctgaagcagc agaaggctag cgcggagctg atcgaagaag aggtggccaa actgctgaag      120

ctgaaggcgc agctgggccc ggacgagagc aaacaaaagt tcgtcctgaa aaccccgaaa      180

tgc                                                                    183


<210>  185
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  185

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Ala Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  186
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  186

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Val Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  187
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  187

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Ala Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  188
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  188

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Ser Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  189
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  189

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Val Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  190
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  190

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Ser 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  191
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  191

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Ser Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  192
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  192
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagg ctgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  193
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  193
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagg ttgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  194
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  194
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag gctttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  195
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  195
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag agtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  196
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  196
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag gttttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  197
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  197
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt ccggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  198
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  198
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctcctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  199
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak consensus sequence

<400>  199
rccrccatgg                                                              10


<210>  200
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  200

Gly Ser Gly Ser 
1               


<210>  201
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  201

Gly Gly Ser Gly 
1               


<210>  202
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  202

Gly Gly Gly Ser 
1               


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  203

Gly Gly Gly Gly Ser 
1               5   


<210>  204
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  204

Gly Asn Gly Asn 
1               


<210>  205
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  205

Gly Gly Asn Gly 
1               


<210>  206
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  206

Gly Gly Gly Asn 
1               


<210>  207
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  207

Gly Gly Gly Gly Asn 
1               5   


<210>  208
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  208

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  209
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  209

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser 
            20          


<210>  210
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  210

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  211
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  211

Asp Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ala Ala Ala Arg Glu 
1               5                   10                  15      


Ala Ala Ala Arg Asp Ala Ala Ala Lys 
            20                  25  


<210>  212
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker sequence

<400>  212

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
1               5                   10                  


<210>  213
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  213

Asp Gly Gly Gly Ser 
1               5   


<210>  214
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  214

Thr Gly Glu Lys Pro 
1               5   


<210>  215
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  215

Gly Gly Arg Arg 
1               


<210>  216
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  216

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  217
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  217

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  218
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  218

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  219
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  219

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  220
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  220

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  221
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker sequence

<400>  221

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  222
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  222

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  223
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  223

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  224
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  224

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  225
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  225

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  226
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  226

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  227
<211>  24
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  227

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  228
<211>  40
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  228

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  229
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  229

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  230
<211>  40
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  230

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  231
<211>  33
<212>  PRT
<213>  Unknown

<220>
<223>  Naturally occurring 2A or 2A-like self cleaving peptide

<400>  231

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  232
<211>  7
<212>  PRT
<213>  Tobacco etch virus


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = any amino acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is either Gly or Ser

<400>  232

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  233
<211>  7
<212>  PRT
<213>  Tobacco etch virus

<400>  233

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  234
<211>  7
<212>  PRT
<213>  Tabacco etch virus

<400>  234

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  235
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  235

Gly Arg Gly Asp 
1               


<210>  236
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  236

Gly Arg Gly Asp Asn Pro 
1               5       


<210>  237
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  237

Gly Arg Gly Asp Ser 
1               5   


<210>  238
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  238

Gly Arg Gly Asp Ser Pro Lys 
1               5           


<210>  239
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  239

Ala Ala Pro Val 
1               


<210>  240
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  240

Ala Ala Pro Leu 
1               


<210>  241
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  241

Ala Ala Pro Phe 
1               


<210>  242
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  242

Ala Ala Pro Ala 
1               


<210>  243
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  243

Ala Tyr Leu Val 
1               


<210>  244
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = Any amino acid

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Any amino acid

<400>  244

Gly Pro Xaa Gly Pro Xaa 
1               5       


<210>  245
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = Any amino acid

<400>  245

Leu Gly Pro Xaa 
1               


<210>  246
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Any amino acid

<400>  246

Gly Pro Ile Gly Pro Xaa 
1               5       


<210>  247
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = Any amino acid

<400>  247

Ala Pro Gly Leu Xaa 
1               5   


<210>  248
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Any amino acid

<400>  248

Pro Leu Gly Pro Asp Arg Xaa 
1               5           


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Any amino acid

<400>  249

Pro Leu Gly Leu Leu Gly Xaa 
1               5           


<210>  250
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  250

Pro Gln Gly Ile Ala Gly Trp 
1               5           


<210>  251
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  251

Pro Leu Gly Cys His 
1               5   


<210>  252
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  252

Pro Leu Gly Leu Tyr Ala 
1               5       


<210>  253
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  253

Pro Leu Ala Leu Trp Ala Arg 
1               5           


<210>  254
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  254

Pro Leu Ala Tyr Trp Ala Arg 
1               5           


<210>  255
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stromelysin cleavable linker

<400>  255

Pro Tyr Ala Tyr Tyr Met Arg 
1               5           


<210>  256
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gelatinase cleavable linker

<400>  256

Pro Leu Gly Met Tyr Ser Arg 
1               5           


<210>  257
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin converting enzyme cleavable linker

<400>  257

Gly Asp Lys Pro 
1               


<210>  258
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin converting enzyme cleavable linker

<400>  258

Gly Ser Asp Lys Pro 
1               5   


<210>  259
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cathepsin B cleavable linker

<400>  259

Ala Leu Ala Leu 
1               


<210>  260
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cathepsin B cleavable linker

<400>  260

Gly Phe Leu Gly 
1               


<210>  261
<211>  198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized DNA sequence for HRS polypeptide with 6xHis tag

<400>  261
atggcagaac gtgcggcatt ggaagaattg gttaaactgc aaggtgaacg tgttcgtggt       60

ctgaagcagc agaaggctag cgcggagctg atcgaagaag aggtggccaa actgctgaag      120

ctgaaggcgc agctgggccc ggacgagagc aaacaaaagt tcgtcctgaa aaccccgaaa      180

caccaccatc accatcac                                                    198


<210>  262
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS polypeptide with 6xHis tag

<400>  262

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys His His His His 
    50                  55                  60                  


His His 
65      


<210>  263
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized DNA sequence for HRS polypeptide with 6xHis tag

<400>  263
atgtgtgcag aaagagccgc cctggaagag ttagttaagt tgcaaggtga acgtgtccgt       60

ggtctgaagc agcagaaggc tagcgcggag ctgatcgaag aagaggtggc caaactgctg      120

aagctgaagg cgcagctggg cccggacgag agcaaacaaa agttcgtcct gaaaaccccg      180

aaacaccacc atcaccatca c                                                201


<210>  264
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS polypeptide with 6xHis tag

<400>  264

Met Cys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly 
1               5                   10                  15      


Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile 
            20                  25                  30          


Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
        35                  40                  45              


Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys His His His 
    50                  55                  60                  


His His His 
65          


<210>  265
<211>  198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized DNA sequence for HRS polypeptide with 6xHis tag

<400>  265
atggcagaac gtgcggcatt ggaagaattg gttaaactgc aaggtgaacg tgttcgtggt       60

ctgaagcagc agaagtgcag cgcggagctg atcgaagaag aggtggccaa actgctgaag      120

ctgaaggcgc agctgggccc ggacgagagc aaacaaaagt tcgtcctgaa aaccccgaaa      180

caccaccatc accatcac                                                    198


<210>  266
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS polypeptide with 6xHis tag

<400>  266

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Cys Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys His His His His 
    50                  55                  60                  


His His 
65      


<210>  267
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized DNA sequence for HRS polypeptide with 6xHis tag

<400>  267
atggcagaac gtgcggcatt ggaagaattg gttaaactgc aaggtgaacg tgttcgtggt       60

ctgaagcagc agaaggctag cgcggagctg atcgaagaag aggtggccaa actgctgaag      120

ctgaaggcgc agctgggccc ggacgagagc aaacaaaagt tcgtcctgaa aaccccgaaa      180

tgccaccacc atcaccatca c                                                201


<210>  268
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS polypeptide with 6xHis tag

<400>  268

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Cys His His His 
    50                  55                  60                  


His His His 
65          


<210>  269
<211>  1563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized DNA for HRS full length protein with 6xHis tag

<400>  269
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgttatg tatttgcgcg gccgcactcg agcaccacca ccaccaccac     1560

tga                                                                   1563


<210>  270
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS full length protein with 6xHis tag

<400>  270

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys Ala Ala Ala 
            500                 505                 510         


Leu Glu His His His His His His 
        515                 520 


<210>  271
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HARS peptide fragment

<400>  271

Val Phe Asp Val Ile Ile Arg Cys Phe Lys 
1               5                   10  


<210>  272
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HARS peptide fragment

<400>  272

Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu 
1               5                   10                  15      


Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile 
            20                  25                  30          


Pro Asp Ala Glu Cys Leu Lys 
        35                  


<210>  273
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HARS peptide fragment

<400>  273

Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val 
1               5                   10                  15      


Lys 
    


<210>  274
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HARS peptide fragment

<400>  274

Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val 
1               5                   10                  15      


Ser Asp Ser Lys 
            20  


<210>  275
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HARS peptide fragment

<400>  275

Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
1               5                   10  


<210>  276
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HARS peptide fragment

<400>  276

Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys 
1               5                   10              


<210>  277
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HARS peptide fragment

<400>  277

Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile 
1               5                   10                  15      


Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys 
            20                  25          


<210>  278
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HARS peptide fragment

<400>  278

Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val 
1               5                   10                  15      


Ala Ile Ile Gly Glu Gln Glu Leu Lys 
            20                  25  


<210>  279
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HARS peptide fragment

<400>  279

Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
1               5                   10  


<210>  280
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  280
gtttgacgta atcatccgtt gcttcaagcg ccacggtgca g                           41


<210>  281
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  281
ctgcaccgtg gcgcttgaag caacggatga ttacgtcaaa c                           41


<210>  282
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  282
gccgataccg ggaattctac cagtgtgatt ttgacattgc tggg                        44


<210>  283
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  283
cccagcaatg tcaaaatcac actggtagaa ttcccggtat cggc                        44


<210>  284
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  284
ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga g                           41


<210>  285
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  285
ctcgcacatg atcttcaggc actctgcatc agggatcatg g                           41


<210>  286
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  286
gcagagtgcc tgaagatcat gtgcgagatc ctgagttcac ttc                         43


<210>  287
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  287
gaagtgaact caggatctcg cacatgatct tcaggcactc tgc                         43


<210>  288
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  288
ctagatggga tgtttgctat ctgtggtgtt tctgacagca agttc                       45


<210>  289
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  289
gaacttgctg tcagaaacac cacagatagc aaacatccca tctag                       45


<210>  290
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  290
cagcaagttc cgtaccatct gctcctcagt agacaagctg g                           41


<210>  291
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  291
ccagcttgtc tactgaggag cagatggtac ggaacttgct g                           41


<210>  292
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  292
gggcgcaagg tgccatgtgt ggggctcagc attgggg                                37


<210>  293
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  293
ccccaatgct gagccccaca catggcacct tgcgccc                                37


<210>  294
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  294
ctgaaccagt tacagtactg tgaggaggca ggcatccc                               38


<210>  295
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  295
gggatgcctg cctcctcaca gtactgtaac tggttcag                               38


<210>  296
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  296
gagaacaggc cagcccctct gcatctgcta gaacccagc                              39


<210>  297
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  297
gctgggttct agcagatgca gaggggctgg cctgttctc                              39


<210>  298
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  298
ccagcccctc tgcatctgct agaacccagc tttcttg                                37


<210>  299
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  299
caagaaagct gggttctagc agatgcagag gggctgg                                37


<210>  300
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  300
gaacaggcca gcccctctag aacccagctt tcttg                                  35


<210>  301
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  301
caagaaagct gggttctaga ggggctggcc tgttc                                  35


<210>  302
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  302
cccggatgcc gaggctttga aaattatgtg                                        30


<210>  303
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  303
cacataattt tcaaagcctc ggcatccggg                                        30


<210>  304
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  304
gatcccggat gccgagagtt tgaaaattat gtgtg                                  35


<210>  305
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  305
cacacataat tttcaaactc tcggcatccg ggatc                                  35


<210>  306
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  306
gatcccggat gccgaggttt tgaaaattat gtgtg                                  35


<210>  307
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  307
cacacataat tttcaaaacc tcggcatccg ggatc                                  35


<210>  308
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  308
cgcgaattct atcaggctga ttttgatatt gccgg                                  35


<210>  309
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  309
ccggcaatat caaaatcagc ctgatagaat tcgcg                                  35


<210>  310
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  310
cgcgaattct atcaggttga ttttgatatt gccg                                   34


<210>  311
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  311
cggcaatatc aaaatcaacc tgatagaatt cgcg                                   34


<210>  312
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  312
ggtatgtttg ctatttccgg tgtttctgat tcc                                    33


<210>  313
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  313
ggaatcagaa acaccggaaa tagcaaacat acc                                    33


<210>  314
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  314
ccaaattccg tacaatctcc tcaagcgtgg acaaattgg                              39


<210>  315
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  315
ccaatttgtc cacgcttgag gagattgtac ggaatttgg                              39


<210>  316
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  316
cccggatgcc gaggctttga aaattatgtg                                        30


<210>  317
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  317
cacataattt tcaaagcctc ggcatccggg                                        30


<210>  318
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for tag free HRS polypeptide

<400>  318
cgccgcaccg gtcaaccgtt acaccaccac caccaccact g                           41


<210>  319
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for tag free HRS polypeptide

<400>  319
cagtggtggt ggtggtggtg taacggttga ccggtgcggc g                           41


<210>  320
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for tag free HRS polypeptide

<400>  320
cgccgcaccg gtcaaccgtt atgagatccg gctgctaac                              39


<210>  321
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for tag free HRS polypeptide

<400>  321
gttagcagcc ggatctcata acggttgacc ggtgcggcg                              39


<210>  322
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRS WHEP consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(6)
<223>  Xaa = Any Amino Acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaa = Any Amino Acid or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Xaa = Any Amino Acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = Any Amino Acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(19)
<223>  Xaa = Any Amino Acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(28)
<223>  Xaa = Any Amino Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(30)
<223>  Xaa = Any Amino Acid or Absent

<220>
<221>  MISC_FEATURE
<222>  (32)..(33)
<223>  Xaa = Any Amino Acid

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa = Any Amino Acid

<400>  322

Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Gly Xaa Xaa Val Arg Xaa Leu 
1               5                   10                  15      


Lys Xaa Xaa Lys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa 
            20                  25                  30          


Xaa Leu Leu Xaa Leu Lys 
        35              


<210>  323
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the N-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  323
taattttgtt taactttaag aaggagatat acatatgtct gacaaaactc acacatgccc       60


<210>  324
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the N-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  324
agcctctccc tgtctccggg taaagcagag cgtgcggcgc tgg                         43


<210>  325
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the N-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  325
ccagcgccgc acgctctgct ttacccggag acagggagag gct                         43


<210>  326
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the N-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  326
ttttgtttaa ctttaagaag gagatataca tatgtctgac aaaactcaca catgccc          57


<210>  327
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the N-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  327
ctctccctgt ctccgggtaa agcagagcgt gcggcgc                                37


<210>  328
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the N-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  328
gcgccgcacg ctctgcttta cccggagaca gggagag                                37


<210>  329
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the C-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  329
caaacagaaa tttgtgctca aaacccccaa gtctgacaaa actcacacat gcccaccg         58


<210>  330
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the C-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  330
agcctctccc tgtctccggg taaatgagat ccggctgcta acaaagccc                   49


<210>  331
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the C-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  331
gggctttgtt agcagccgga tctcatttac ccggagacag ggagaggct                   49


<210>  332
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the C-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  332
cagaaatttg tgctcaaaac ccccaagtct gacaaaactc acacatgccc                  50


<210>  333
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the C-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  333
ctctccctgt ctccgggtaa atgagatccg gctgctaaca aag                         43


<210>  334
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to create the C-terminally fused HRS(1-60) Fc fusion 
       protein

<400>  334
ctttgttagc agccggatct catttacccg gagacaggga gag                         43


<210>  335
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of FC-HRS(1-60) (N-terminal Fc fusion)

<400>  335
atgtctgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg       60

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      120

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      180

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      300

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      600

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag      660

aagagcctct ccctgtctcc gggtaaagca gagcgtgcgg cgctggagga gctggtgaaa      720

cttcagggag agcgcgtgcg aggcctcaag cagcagaagg ccagcgccga gctgatcgag      780

gaggaggtgg cgaaactcct gaaactgaag gcacagctgg gtcctgatga aagcaaacag      840

aaatttgtgc tcaaaacccc caagtga                                          867


<210>  336
<211>  866
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of HRS(1-60)-Fc (C-terminal Fc fusion)

<400>  336
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgggtcc tgatgaagca aacagaaatt tgtgctcaaa acccccaagt      180

ctgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg ggaccgtcag      240

tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca      300

catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg      360

acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt      420

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc aaggagtaca      480

agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaagcca      540

aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag gagatgacca      600

agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg      660

agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact      720

ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg      780

ggaacgtctt ctcatgctcc gtgatgcacg aggctctgca caaccactac acgcagaaga      840

gcctctccct gtctccgggt aaatga                                           866


<210>  337
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Fc-HRS(1-60) (N-terminal Fc fusion)

<400>  337

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        275                 280                 285             


<210>  338
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of HRS(1-60)-Fc (C-terminal Fc fusion)

<400>  338

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ser Asp Lys Thr 
    50                  55                  60                  


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
65                  70                  75                  80  


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                85                  90                  95      


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            100                 105                 110         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        115                 120                 125             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    130                 135                 140                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
145                 150                 155                 160 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                165                 170                 175     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            180                 185                 190         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        195                 200                 205             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    210                 215                 220                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
225                 230                 235                 240 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                245                 250                 255     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            260                 265                 270         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280                 285             


<210>  339
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys 
225                 


<210>  340
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  340

Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  341
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified human IgG1 hinge region

<400>  341

Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10      


<210>  342
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys 
225                 


<210>  343
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS (2-60)

<400>  343
gatatacata tgtctgacaa aactcacaca tgcc                                   34


<210>  344
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS (2-60)

<400>  344
gatcctcgag tcacttgggg gttttg                                            26


<210>  345
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS (1-60)-Fc

<400>  345
gatatacata tggcagagcg tgcgg                                             25


<210>  346
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS (1-60)-Fc

<400>  346
gatcctcgag tcatttaccc ggagac                                            26


<210>  347
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Fc-HRS(2-60)

<400>  347
atgtctgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg       60

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      120

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      180

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      300

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      600

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag      660

aagagcctct ccctgtctcc gggtaaagca gagcgtgcgg cgctggagga gctggtgaaa      720

cttcagggag agcgcgtgcg aggcctcaag cagcagaagg ccagcgccga gctgatcgag      780

gaggaggtgg cgaaactcct gaaactgaag gcacagctgg gtcctgatga aagcaaacag      840

aaatttgtgc tcaaaacccc caagtga                                          867


<210>  348
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of HRS(1-60)-Fc (C-terminal Fc fusion)

<400>  348
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag      180

tctgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      240

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      300

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      360

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      420

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      480

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      540

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc      600

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      660

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      720

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      780

gggaacgtct tctcatgctc cgtgatgcac gaggctctgc acaaccacta cacgcagaag      840

agcctctccc tgtctccggg taaatga                                          867


<210>  349
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Fc-HRS(2-60) (N-terminal Fc fusion)

<400>  349

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        275                 280                 285             


<210>  350
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of HRS(1-60)-Fc (C-terminal Fc fusion)

<400>  350

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ser Asp Lys Thr 
    50                  55                  60                  


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
65                  70                  75                  80  


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                85                  90                  95      


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            100                 105                 110         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        115                 120                 125             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    130                 135                 140                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
145                 150                 155                 160 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                165                 170                 175     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            180                 185                 190         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        195                 200                 205             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    210                 215                 220                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
225                 230                 235                 240 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                245                 250                 255     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            260                 265                 270         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280                 285             


<210>  351
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  351
ggtggcgaaa ctcctgaaat gactcgagga tccggctgc                              39


<210>  352
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  352
gcagccggat cctcgagtca tttcaggagt ttcgccacc                              39


<210>  353
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  353
ctgaaggcac agctgtgact cgaggatccg gctgc                                  35


<210>  354
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  354
gcagccggat cctcgagtca cagctgtgcc ttcag                                  35


<210>  355
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  355
gggtcctgat gaaagctgac tcgaggatcc ggctgc                                 36


<210>  356
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  356
gcagccggat cctcgagtca gctttcatca ggaccc                                 36


<210>  357
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  357
gcaaacagaa atttgtgtga ctcgaggatc cggctgc                                37


<210>  358
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  358
gcagccggat cctcgagtca cacaaatttc tgtttgc                                37


<210>  359
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  359
gctcaaaacc cccaagggaa cccgtgatta tagttgactc gaggatccgg                  50


<210>  360
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify Fc-HRS polypeptides

<400>  360
ccggatcctc gagtcaacta taatcacggg ttcccttggg ggttttgagc                  50


<210>  361
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  361
ggtggcgaaa ctcctgaaat ctgacaaaac tcacacatgc                             40


<210>  362
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  362
gcatgtgtga gttttgtcag atttcaggag tttcgccacc                             40


<210>  363
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  363
ctgaaactga aggcacagct gtctgacaaa actcacacat gc                          42


<210>  364
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  364
gcatgtgtga gttttgtcag acagctgtgc cttcagtttc ag                          42


<210>  365
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  365
gctgggtcct gatgaaagct ctgacaaaac tcacacatgc                             40


<210>  366
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  366
gcatgtgtga gttttgtcag agctttcatc aggacccagc                             40


<210>  367
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  367
gaaagcaaac agaaatttgt gtctgacaaa actcacacat gc                          42


<210>  368
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  368
gcatgtgtga gttttgtcag acacaaattt ctgtttgctt tc                          42


<210>  369
<211>  49
<212>  DNA
<213>  Artificial Sequenc

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  369
gctcaaaacc cccaagggaa cccgtgatta tagttctgac aaaactcac                   49


<210>  370
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer to amplify HRS-Fc polypeptides

<400>  370
gtgagttttg tcagaactat aatcacgggt tcccttgggg gttttgagc                   49


<210>  371
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Fc-HRS (2-40) (N-terminal Fc fusion)

<400>  371
atgtctgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg       60

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      120

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      180

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      300

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      600

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag      660

aagagcctct ccctgtctcc gggtaaagca gagcgtgcgg cgctggagga gctggtgaaa      720

cttcagggag agcgcgtgcg aggcctcaag cagcagaagg ccagcgccga gctgatcgag      780

gaggaggtgg cgaaactcct gaaatga                                          807


<210>  372
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Fc-HRS (2-45) (N-terminal Fc fusion)

<400>  372
atgtctgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg       60

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      120

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      180

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      300

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      600

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag      660

aagagcctct ccctgtctcc gggtaaagca gagcgtgcgg cgctggagga gctggtgaaa      720

cttcagggag agcgcgtgcg aggcctcaag cagcagaagg ccagcgccga gctgatcgag      780

gaggaggtgg cgaaactcct gaaactgaag gcacagctgt ga                         822


<210>  373
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Fc-HRS (2-50) (N-terminal Fc fusion)

<400>  373
atgtctgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg       60

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      120

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      180

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      300

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      600

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag      660

aagagcctct ccctgtctcc gggtaaagca gagcgtgcgg cgctggagga gctggtgaaa      720

cttcagggag agcgcgtgcg aggcctcaag cagcagaagg ccagcgccga gctgatcgag      780

gaggaggtgg cgaaactcct gaaactgaag gcacagctgg gtcctgatga aagctga         837


<210>  374
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Fc-HRS (2-55) (N-terminal Fc fusion)

<400>  374
atgtctgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg       60

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      120

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      180

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      300

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      600

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag      660

aagagcctct ccctgtctcc gggtaaagca gagcgtgcgg cgctggagga gctggtgaaa      720

cttcagggag agcgcgtgcg aggcctcaag cagcagaagg ccagcgccga gctgatcgag      780

gaggaggtgg cgaaactcct gaaactgaag gcacagctgg gtcctgatga aagcaaacag      840

aaatttgtgt ga                                                          852


<210>  375
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Fc-HRS (2-66) (N-terminal Fc fusion)

<400>  375
atgtctgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg       60

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      120

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      180

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      300

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      600

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag      660

aagagcctct ccctgtctcc gggtaaagca gagcgtgcgg cgctggagga gctggtgaaa      720

cttcagggag agcgcgtgcg aggcctcaag cagcagaagg ccagcgccga gctgatcgag      780

gaggaggtgg cgaaactcct gaaactgaag gcacagctgg gtcctgatga aagcaaacag      840

aaatttgtgc tcaaaacccc caagggaacc cgtgattata gttga                      885


<210>  376
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of HRS(1-40)-Fc (C-terminal Fc fusion)

<400>  376
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

tctgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      180

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      240

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      300

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      360

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      420

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      480

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc      540

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      600

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      660

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      720

gggaacgtct tctcatgctc cgtgatgcac gaggctctgc acaaccacta cacgcagaag      780

agcctctccc tgtctccggg taaatga                                          807


<210>  377
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of HRS(1-45)-Fc (C-terminal Fc fusion)

<400>  377
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgtctga caaaactcac acatgcccac cgtgcccagc acctgaactc      180

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      240

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      300

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      360

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      420

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa      480

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      540

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc      600

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      660

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      720

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac      780

cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                         822


<210>  378
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of HRS(1-50)-Fc (C-terminal Fc fusion)

<400>  378
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgggtcc tgatgaaagc tctgacaaaa ctcacacatg cccaccgtgc      180

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      240

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      300

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      360

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      420

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      480

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      540

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc      600

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      660

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag      720

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcac      780

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga         837


<210>  379
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of HRS(1-55)-Fc (C-terminal Fc fusion)

<400>  379
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgtctga caaaactcac      180

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      240

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      300

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      360

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      420

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      480

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga      540

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc      600

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat      660

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc      720

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca      780

tgctccgtga tgcacgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct      840

ccgggtaaat ga                                                          852


<210>  380
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of HRS(1-66)-Fc (C-terminal Fc fusion)

<400>  380
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag      180

ggaacccgtg attatagttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      240

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      300

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      360

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      420

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      480

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      540

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      600

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      660

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      720

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      780

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcacga ggctctgcac      840

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                      885


<210>  381
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Fc-HRS (2-40) (N-terminal Fc fusion)

<400>  381

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys 
            260                 265             


<210>  382
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Fc-HRS (2-45) (N-terminal Fc fusion)

<400>  382

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu 
    


<210>  383
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Fc-HRS (2-50) (N-terminal Fc fusion)

<400>  383

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser 
        275             


<210>  384
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Fc-HRS (2-55) (N-terminal Fc fusion)

<400>  384

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
        275                 280             


<210>  385
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Fc-HRS (2-66) (N-terminal Fc fusion)

<400>  385

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        275                 280                 285             


Gly Thr Arg Asp Tyr Ser 
    290                 


<210>  386
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of HRS(1-40)-Fc (C-terminal Fc fusion)

<400>  386

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Ser Asp Lys Thr His Thr Cys Pro 
        35                  40                  45              


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    50                  55                  60                  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
65                  70                  75                  80  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                85                  90                  95      


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            100                 105                 110         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        115                 120                 125             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    130                 135                 140                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
145                 150                 155                 160 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                165                 170                 175     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            180                 185                 190         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        195                 200                 205             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    210                 215                 220                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
225                 230                 235                 240 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                245                 250                 255     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265             


<210>  387
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of HRS(1-45)-Fc (C-terminal Fc fusion)

<400>  387

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Ser Asp Lys 
        35                  40                  45              


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                85                  90                  95      


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            260                 265                 270         


Lys 
    


<210>  388
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of HRS(1-50)-Fc (C-terminal Fc fusion)

<400>  388

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    50                  55                  60                  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
65                  70                  75                  80  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                85                  90                  95      


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            100                 105                 110         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        115                 120                 125             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    130                 135                 140                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
145                 150                 155                 160 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                165                 170                 175     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            180                 185                 190         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        195                 200                 205             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    210                 215                 220                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
225                 230                 235                 240 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                245                 250                 255     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            260                 265                 270         


Ser Leu Ser Pro Gly Lys 
        275             


<210>  389
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of HRS(1-55)-Fc (C-terminal Fc fusion)

<400>  389

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Ser Asp Lys Thr His Thr Cys Pro Pro 
    50                  55                  60                  


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
65                  70                  75                  80  


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                85                  90                  95      


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            100                 105                 110         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        115                 120                 125             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    130                 135                 140                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
145                 150                 155                 160 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                165                 170                 175     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            180                 185                 190         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        195                 200                 205             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    210                 215                 220                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
225                 230                 235                 240 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                245                 250                 255     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            260                 265                 270         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280             


<210>  390
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of HRS(1-66)-Fc (C-terminal Fc fusion)

<400>  390

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    130                 135                 140                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  391
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer used to amplify Fc-HRS (2-60)

<400>  391
tattctcgag gcagagcgtg cggc                                              24


<210>  392
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer used to amplify Fc-HRS (2-60)

<400>  392
gcgcctcgag tcacttgggg gttttg                                            26


<210>  393
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer used to amplify Fc-HRS (2-60)

<400>  393
gtgctcaaaa cccccaaggc agagcgtgcg gcgctgg                                37


<210>  394
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer used to amplify Fc-HRS (2-60)

<400>  394
ccagcgccgc acgctctgcc ttgggggttt tgagcac                                37


<210>  395
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Fc-HRS(2-60) HRS(2-60) (N-terminal Fc fusion)

<400>  395
atgtctgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg       60

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      120

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      180

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      240

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      300

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      360

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg      420

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      480

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      540

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      600

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag      660

aagagcctct ccctgtctcc gggtaaagca gagcgtgcgg cgctggagga gctggtgaaa      720

cttcagggag agcgcgtgcg aggcctcaag cagcagaagg ccagcgccga gctgatcgag      780

gaggaggtgg cgaaactcct gaaactgaag gcacagctgg gtcctgatga aagcaaacag      840

aaatttgtgc tcaaaacccc caaggcagag cgtgcggcgc tggaggagct ggtgaaactt      900

cagggagagc gcgtgcgagg cctcaagcag cagaaggcca gcgccgagct gatcgaggag      960

gaggtggcga aactcctgaa actgaaggca cagctgggtc ctgatgaaag caaacagaaa     1020

tttgtgctca aaacccccaa gtga                                            1044


<210>  396
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of Fc-HRS(2-60) HRS(2-60) (N-terminal Fc fusion)

<400>  396

Met Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys 
225                 230                 235                 240 


Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
                245                 250                 255     


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            260                 265                 270         


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        275                 280                 285             


Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg 
    290                 295                 300                 


Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
305                 310                 315                 320 


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
                325                 330                 335     


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
            340                 345         


