                         SEQUENCE LISTING

<110>  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
       WEINER, David
       MUTHUMANI, Karuppiah
 
<120>  VACCINES WITH BIOMOLECULAR ADJUVANTS

<130>  UPVG0048WO

<150>  61800328
<151>  2013-03-15

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rel-A

<400>  1
atggattgga cttggatctt atttttagtt gctgctgcta ctagagttca ttctgacgat       60

ctgtttcccc tcatctttcc ctcagagcca gcccaggctt ctgggcctta tgtggagatc      120

atcgaacagc cgaagcaacg gggcatgcga ttccgctata aatgcgaggg gcgctcagcg      180

ggcagtattc ctggcgagag aagcacagat accaccaaga cacaccccac catcaagatc      240

aatggctaca caggaccagg aacagttcga atctccctgg tcaccaagga tccacctcac      300

cggcctcatc cacatgaact tgtggggaag gactgccggg atggctacta tgaggctgac      360

ctctgcccag accgcagtat ccatagcttc cagaacctgg ggatccagtg tgtgaagaag      420

cgagacctgg agcaagccat tagccagcga atccagacca acaataaccc ctttcacgtt      480

cctatagagg agcagcgcgg ggactatgac ttgaatgcag tgcgcctctg cttccaggtg      540

acagtgcggg acccagcagg caggcccctc ctcctgaccc ctgtcctctc acatccgatt      600

tttgataacc gggcccccaa cactgccgag ctcaagatct gccgagtaaa ccggaactct      660

gggagctgcc tcggtgggga tgagatcttc ttgctgtgcg acaaggtgca gaaagaagac      720

attgaggtgt atttcacggg accaggctgg gaggcacgag gctccttttc tcaagctgat      780

gtgcatcggc aagtggccat tgtgttccgg actcctccgt acgccgaccc cagcctccag      840

gctcctgttc gagtctccat gcagctacgg cggccttctg atcgcgagct cagtgagccc      900

atggagttcc agtacttgcc agacacagat gatcgccacc ggattgaaga gaagcgcaaa      960

aggacctatg agaccttcaa gagtatcatg aagaagagtc ctttcaatgg accaactgaa     1020

ccccggcctc caacccggcg tattgctgtg cctacccgaa actcaacttc tgtccccaag     1080

ccagccccgc agccctacac cttcccagca tccctcagca ccatcaactt tgatgagttt     1140

tcccccatgc tgttaccatc agggcagatc tcaaaccagg ccctggcctt agcaccgtcc     1200

tctgccccag tccttgccca gaccatggtc ccttcctcag ccatggtacc tctggctcag     1260

cccccagctc ctgccccagt tctaaccccg ggtcctcccc agtccctgtc tgcacctgtt     1320

ccaaagagca cccaggctgg ggaaggcacg ctgtcggaag ccctgctgca cctgcagttt     1380

gatgctgatg aagacttggg ggccttgctt ggcaacagca cagacccagg agtgttcaca     1440

gacctggcat ctgtggacaa ctcagagttt cagcagctcc tgaaccaggg tgtgtccatg     1500

tctcactcca cagctgagcc catgctgatg gagtaccctg aagctataac tcgcctggtg     1560

acagggtccc agaggccccc tgacccagct cccacacccc tggggacctc ggggcttccc     1620

aatggtctct ccggagatga agacttctcc tccattgcgg acatggactt ctctgctctt     1680

ttgagtcaga tcagctcctg ataa                                            1704


<210>  2
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rel-A

<400>  2

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Asp Leu Phe Pro Leu Ile Phe Pro Ser Glu Pro Ala Gln 
            20                  25                  30          


Ala Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly 
        35                  40                  45              


Met Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro 
    50                  55                  60                  


Gly Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile 
65                  70                  75                  80  


Asn Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys 
                85                  90                  95      


Asp Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys 
            100                 105                 110         


Arg Asp Gly Tyr Tyr Glu Ala Asp Leu Cys Pro Asp Arg Ser Ile His 
        115                 120                 125             


Ser Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu 
    130                 135                 140                 


Gln Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe His Val 
145                 150                 155                 160 


Pro Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu 
                165                 170                 175     


Cys Phe Gln Val Thr Val Arg Asp Pro Ala Gly Arg Pro Leu Leu Leu 
            180                 185                 190         


Thr Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr 
        195                 200                 205             


Ala Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu 
    210                 215                 220                 


Gly Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp 
225                 230                 235                 240 


Ile Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe 
                245                 250                 255     


Ser Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro 
            260                 265                 270         


Pro Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln 
        275                 280                 285             


Leu Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln 
    290                 295                 300                 


Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys 
305                 310                 315                 320 


Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Asn 
                325                 330                 335     


Gly Pro Thr Glu Pro Arg Pro Pro Thr Arg Arg Ile Ala Val Pro Thr 
            340                 345                 350         


Arg Asn Ser Thr Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Thr Phe 
        355                 360                 365             


Pro Ala Ser Leu Ser Thr Ile Asn Phe Asp Glu Phe Ser Pro Met Leu 
    370                 375                 380                 


Leu Pro Ser Gly Gln Ile Ser Asn Gln Ala Leu Ala Leu Ala Pro Ser 
385                 390                 395                 400 


Ser Ala Pro Val Leu Ala Gln Thr Met Val Pro Ser Ser Ala Met Val 
                405                 410                 415     


Pro Leu Ala Gln Pro Pro Ala Pro Ala Pro Val Leu Thr Pro Gly Pro 
            420                 425                 430         


Pro Gln Ser Leu Ser Ala Pro Val Pro Lys Ser Thr Gln Ala Gly Glu 
        435                 440                 445             


Gly Thr Leu Ser Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu 
    450                 455                 460                 


Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Gly Val Phe Thr 
465                 470                 475                 480 


Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln 
                485                 490                 495     


Gly Val Ser Met Ser His Ser Thr Ala Glu Pro Met Leu Met Glu Tyr 
            500                 505                 510         


Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp 
        515                 520                 525             


Pro Ala Pro Thr Pro Leu Gly Thr Ser Gly Leu Pro Asn Gly Leu Ser 
    530                 535                 540                 


Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu 
545                 550                 555                 560 


Leu Ser Gln Ile Ser Ser 
                565     


<210>  3
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T-bet

<400>  3
atggattgga cttggatctt atttttagtt gctgctgcta ctagagttca ttctgggatt       60

gtggaacctg gatgtggaga tatgctgact ggaacagaac ctatgccttc agatgagggg      120

agaggacccg gcgcagatca gcagcacaga ttcttttacc cagagccagg agcacaggac      180

cctactgata ggagagctgg cagctccctg ggaaccccat acagcggagg agccctggtc      240

cctgcagctc cagggcgctt cctgggctcc tttgcttatc cacccagggc ccaggtggct      300

ggatttcctg gaccagggga gttctttcca ccccctgctg gagcagaagg gtacccaccc      360

gtggacggct atcccgctcc tgatccacga gcaggactgt accccgggcc tagggaggac      420

tatgcactgc cagccggcct ggaagtgtcc ggaaagctgc gggtcgccct gtccaaccac      480

ctgctgtggt ctaagttcaa tcagcatcag accgagatga tcattacaaa acagggcagg      540

aggatgttcc catttctgtc ttttactgtg gccggactgg aacccaccag tcactacagg      600

atgttcgtgg acgtggtcct ggtcgatcag caccattgga gatatcagtc cggaaagtgg      660

gtgcagtgcg gcaaagcaga gggatctatg ccaggaaacc gactgtacgt ccacccagat      720

agtcctaata caggcgctca ttggatgcgc caggaagtga gctttggaaa gctgaaactg      780

acaaacaata agggggcctc aaacaatgtg actcagatga tcgtcctgca gagcctgcac      840

aaatatcagc cccgcctgca tattgtggag gtcaacgacg gagagcctga agcagcatgc      900

tccgcttcta atacccacgt gttcacattt caggagactc agttcatcgc tgtcacagca      960

taccagaacg ccgaaatcac tcagctgaag attgataaca atcctttcgc taaaggattt     1020

cgagagaatt tcgaatctat gtatgcaagt gtggacacta gcgtcccatc ccctccagga     1080

cctaactgtc agctgctggg gggcgatcca ttttcacccc tgctgagcaa tcagtaccca     1140

gtgcccagca ggttctatcc tgacctgcca gggcagccca aggatatgat ttctcagcca     1200

tactggctgg gcacccccag agagcatagc tatgaggcag aatttcgggc cgtgagcatg     1260

aaaccaaccc tgctgccatc cgcccctgga ccaacagtgc cctactatag gggacaggac     1320

gtgctggcac ctggagctgg atggcctgtg gcaccacagt acccccctaa gatgtctcct     1380

gcaggatggt tccgaccaat gcgcaccctg ccaatggacc ccggactggg ctctagtgag     1440

gaacagggat caagccctag tctgtggcca gaggtgacct cactgcagcc cgaacctagt     1500

gactcaggac tgggggaggg cgatacaaaa cgaaggagaa tcagcccata tccctcctct     1560

ggcgacagtt caagccccgc cggagcacca tccccatttg ataaggagac cgaaggccag     1620

ttctacaatt actttcccaa ctgataa                                         1647


<210>  4
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T-bet

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile Val Glu Pro Gly Cys Gly Asp Met Leu Thr Gly Thr 
            20                  25                  30          


Glu Pro Met Pro Ser Asp Glu Gly Arg Gly Pro Gly Ala Asp Gln Gln 
        35                  40                  45              


His Arg Phe Phe Tyr Pro Glu Pro Gly Ala Gln Asp Pro Thr Asp Arg 
    50                  55                  60                  


Arg Ala Gly Ser Ser Leu Gly Thr Pro Tyr Ser Gly Gly Ala Leu Val 
65                  70                  75                  80  


Pro Ala Ala Pro Gly Arg Phe Leu Gly Ser Phe Ala Tyr Pro Pro Arg 
                85                  90                  95      


Ala Gln Val Ala Gly Phe Pro Gly Pro Gly Glu Phe Phe Pro Pro Pro 
            100                 105                 110         


Ala Gly Ala Glu Gly Tyr Pro Pro Val Asp Gly Tyr Pro Ala Pro Asp 
        115                 120                 125             


Pro Arg Ala Gly Leu Tyr Pro Gly Pro Arg Glu Asp Tyr Ala Leu Pro 
    130                 135                 140                 


Ala Gly Leu Glu Val Ser Gly Lys Leu Arg Val Ala Leu Ser Asn His 
145                 150                 155                 160 


Leu Leu Trp Ser Lys Phe Asn Gln His Gln Thr Glu Met Ile Ile Thr 
                165                 170                 175     


Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Thr Val Ala Gly 
            180                 185                 190         


Leu Glu Pro Thr Ser His Tyr Arg Met Phe Val Asp Val Val Leu Val 
        195                 200                 205             


Asp Gln His His Trp Arg Tyr Gln Ser Gly Lys Trp Val Gln Cys Gly 
    210                 215                 220                 


Lys Ala Glu Gly Ser Met Pro Gly Asn Arg Leu Tyr Val His Pro Asp 
225                 230                 235                 240 


Ser Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Val Ser Phe Gly 
                245                 250                 255     


Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn Val Thr Gln 
            260                 265                 270         


Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu His Ile 
        275                 280                 285             


Val Glu Val Asn Asp Gly Glu Pro Glu Ala Ala Cys Ser Ala Ser Asn 
    290                 295                 300                 


Thr His Val Phe Thr Phe Gln Glu Thr Gln Phe Ile Ala Val Thr Ala 
305                 310                 315                 320 


Tyr Gln Asn Ala Glu Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe 
                325                 330                 335     


Ala Lys Gly Phe Arg Glu Asn Phe Glu Ser Met Tyr Ala Ser Val Asp 
            340                 345                 350         


Thr Ser Val Pro Ser Pro Pro Gly Pro Asn Cys Gln Leu Leu Gly Gly 
        355                 360                 365             


Asp Pro Phe Ser Pro Leu Leu Ser Asn Gln Tyr Pro Val Pro Ser Arg 
    370                 375                 380                 


Phe Tyr Pro Asp Leu Pro Gly Gln Pro Lys Asp Met Ile Ser Gln Pro 
385                 390                 395                 400 


Tyr Trp Leu Gly Thr Pro Arg Glu His Ser Tyr Glu Ala Glu Phe Arg 
                405                 410                 415     


Ala Val Ser Met Lys Pro Thr Leu Leu Pro Ser Ala Pro Gly Pro Thr 
            420                 425                 430         


Val Pro Tyr Tyr Arg Gly Gln Asp Val Leu Ala Pro Gly Ala Gly Trp 
        435                 440                 445             


Pro Val Ala Pro Gln Tyr Pro Pro Lys Met Ser Pro Ala Gly Trp Phe 
    450                 455                 460                 


Arg Pro Met Arg Thr Leu Pro Met Asp Pro Gly Leu Gly Ser Ser Glu 
465                 470                 475                 480 


Glu Gln Gly Ser Ser Pro Ser Leu Trp Pro Glu Val Thr Ser Leu Gln 
                485                 490                 495     


Pro Glu Pro Ser Asp Ser Gly Leu Gly Glu Gly Asp Thr Lys Arg Arg 
            500                 505                 510         


Arg Ile Ser Pro Tyr Pro Ser Ser Gly Asp Ser Ser Ser Pro Ala Gly 
        515                 520                 525             


Ala Pro Ser Pro Phe Asp Lys Glu Thr Glu Gly Gln Phe Tyr Asn Tyr 
    530                 535                 540                 


Phe Pro Asn 
545         


<210>  5
<211>  1881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Eomes

<400>  5
atggattgga cttggatctt atttttagtt gctgctgcta ctagagttca ttctcttagt       60

gacaccgacg ccggggacgc atttgccagc gctgcggcag tggccaagcc ggggcccccg      120

gacggccgca agggctcccc ctgcggggag gaggagctgc cctccgccgc tgcagccgcc      180

gccgccgccg ccgccgcggc tgcggccact gcgcgctact ccatggacag cctgagctcc      240

gagcggtact acctccagtc ccccggtcct caggggtcgg agctggctgc gccctgctca      300

ctcttcccgt accaggcggc ggctggggcg ccccacggac ctgtgtaccc ggctcctaac      360

ggggcgcgct acccctacgg ctccatgctg ccccccggcg gcttccccgc ggctgtgtgc      420

ccacccggga gggcgcagtt cggcccagga gccggtgcgg gcagtggcgc gggcggtagc      480

agcggcgggg gcggcggccc gggcacctat cagtacagcc agggggctcc gctctacggg      540

ccgtaccctg gagccgcagc ggcgggatct tgcggaggac tggggggcct gggggttcca      600

ggttctggct tccgtgccca cgtctacctg tgcaaccggc ctctgtggct caaattccac      660

cgccaccaaa ctgagatgat cattacgaaa cagggcaggc gcatgtttcc tttcttgagc      720

ttcaacataa acggactcaa tcccactgcc cactacaatg tgttcgtaga ggtggtgctg      780

gcggacccca accactggcg cttccagggg ggcaaatggg tgacctgtgg caaagccgac      840

aataacatgc agggcaacaa aatgtatgtt cacccagagt ctcctaatac tggttcccac      900

tggatgagac aggagatttc attcgggaaa ttaaaactca ccaataacaa aggcgcaaat      960

aacaacaaca cccagatgat agtcttacaa tccttacaca aataccaacc ccgactgcat     1020

attgttgaag ttacagagga tggcgtggag gacttgaatg agccctcaaa gacccagact     1080

tttaccttct cagaaacgca attcattgca gtgactgcct accaaaacac cgatattact     1140

caactaaaga ttgatcataa cccctttgca aaaggcttca gagacaacta tgattcatcc     1200

catcagattg tccctggagg tcggtacggc gttcaatcct tcttcccgga gccctttgtc     1260

aacactttac ctcaagcccg ctattataat ggcgagagaa ccgtgccaca gaccaacggc     1320

ctcctttcac cccaacagag cgaagaggtg gccaaccctc cccagcggtg gcttgtcacg     1380

cctgtccagc aacctgggac caacaaacta gacatcagtt cctatgaatc tgaatatact     1440

tctagcacat tgctcccata tggcattaaa tccttgcccc ttcagacatc ccatgccctg     1500

gggtattacc cagacccaac ctttcctgca atggcagggt ggggaggtcg aggttcttac     1560

cagaggaaga tggcagctgg actaccatgg acctccagaa caagccccac tgtgttctct     1620

gaagatcagc tctccaagga gaaagtgaaa gaggaaattg gctcttcttg gatagagaca     1680

cccccttcca tcaaatctct agattccaat gattcaggag tatacaccag tgcttgtaag     1740

cgaaggcggc tgtctcctag caactccagt aatgaaaatt caccctccat aaagtgtgag     1800

gacattaatg ctgaagagta tagtaaagac acctcaaaag gcatgggagg gtattatgct     1860

ttttacacaa ctccctgata a                                               1881


<210>  6
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Eomes

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Leu Ser Asp Thr Asp Ala Gly Asp Ala Phe Ala Ser Ala Ala 
            20                  25                  30          


Ala Val Ala Lys Pro Gly Pro Pro Asp Gly Arg Lys Gly Ser Pro Cys 
        35                  40                  45              


Gly Glu Glu Glu Leu Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Thr Ala Arg Tyr Ser Met Asp Ser Leu Ser Ser 
65                  70                  75                  80  


Glu Arg Tyr Tyr Leu Gln Ser Pro Gly Pro Gln Gly Ser Glu Leu Ala 
                85                  90                  95      


Ala Pro Cys Ser Leu Phe Pro Tyr Gln Ala Ala Ala Gly Ala Pro His 
            100                 105                 110         


Gly Pro Val Tyr Pro Ala Pro Asn Gly Ala Arg Tyr Pro Tyr Gly Ser 
        115                 120                 125             


Met Leu Pro Pro Gly Gly Phe Pro Ala Ala Val Cys Pro Pro Gly Arg 
    130                 135                 140                 


Ala Gln Phe Gly Pro Gly Ala Gly Ala Gly Ser Gly Ala Gly Gly Ser 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Gly Pro Gly Thr Tyr Gln Tyr Ser Gln Gly Ala 
                165                 170                 175     


Pro Leu Tyr Gly Pro Tyr Pro Gly Ala Ala Ala Ala Gly Ser Cys Gly 
            180                 185                 190         


Gly Leu Gly Gly Leu Gly Val Pro Gly Ser Gly Phe Arg Ala His Val 
        195                 200                 205             


Tyr Leu Cys Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr 
    210                 215                 220                 


Glu Met Ile Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser 
225                 230                 235                 240 


Phe Asn Ile Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val 
                245                 250                 255     


Glu Val Val Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys 
            260                 265                 270         


Trp Val Thr Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met 
        275                 280                 285             


Tyr Val His Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln 
    290                 295                 300                 


Glu Ile Ser Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn 
305                 310                 315                 320 


Asn Asn Asn Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln 
                325                 330                 335     


Pro Arg Leu His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu 
            340                 345                 350         


Asn Glu Pro Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe 
        355                 360                 365             


Ile Ala Val Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile 
    370                 375                 380                 


Asp His Asn Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Ser 
385                 390                 395                 400 


His Gln Ile Val Pro Gly Gly Arg Tyr Gly Val Gln Ser Phe Phe Pro 
                405                 410                 415     


Glu Pro Phe Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn Gly Glu 
            420                 425                 430         


Arg Thr Val Pro Gln Thr Asn Gly Leu Leu Ser Pro Gln Gln Ser Glu 
        435                 440                 445             


Glu Val Ala Asn Pro Pro Gln Arg Trp Leu Val Thr Pro Val Gln Gln 
    450                 455                 460                 


Pro Gly Thr Asn Lys Leu Asp Ile Ser Ser Tyr Glu Ser Glu Tyr Thr 
465                 470                 475                 480 


Ser Ser Thr Leu Leu Pro Tyr Gly Ile Lys Ser Leu Pro Leu Gln Thr 
                485                 490                 495     


Ser His Ala Leu Gly Tyr Tyr Pro Asp Pro Thr Phe Pro Ala Met Ala 
            500                 505                 510         


Gly Trp Gly Gly Arg Gly Ser Tyr Gln Arg Lys Met Ala Ala Gly Leu 
        515                 520                 525             


Pro Trp Thr Ser Arg Thr Ser Pro Thr Val Phe Ser Glu Asp Gln Leu 
    530                 535                 540                 


Ser Lys Glu Lys Val Lys Glu Glu Ile Gly Ser Ser Trp Ile Glu Thr 
545                 550                 555                 560 


Pro Pro Ser Ile Lys Ser Leu Asp Ser Asn Asp Ser Gly Val Tyr Thr 
                565                 570                 575     


Ser Ala Cys Lys Arg Arg Arg Leu Ser Pro Ser Asn Ser Ser Asn Glu 
            580                 585                 590         


Asn Ser Pro Ser Ile Lys Cys Glu Asp Ile Asn Ala Glu Glu Tyr Ser 
        595                 600                 605             


Lys Asp Thr Ser Lys Gly Met Gly Gly Tyr Tyr Ala Phe Tyr Thr Thr 
    610                 615                 620                 


Pro 
625 


<210>  7
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLT3L

<400>  7
atggattgga cttggatctt atttttagtt gctgctgcta ctagagttca ttctacggtc       60

ctcgcccctg cgtggtcgcc caactcgtca ctgctgttgc tccttctgtt gttgtcaccc      120

tgtttgcgag ggacaccgga ctgttatttc agccatagcc ccatctcgtc caacttcaaa      180

gtaaagtttc gggaactcac tgaccacctt ctcaaagatt accccgtcac agtggcggtg      240

aatcttcaag acgaaaagca ctgtaaggcc ctctggagcc tgtttctggc acagagatgg      300

atcgagcaac ttaaaacggt cgcgggttca aagatgcaga ccctcttgga agatgtgaat      360

acagagattc actttgtcac gtcatgcacc tttcagcctc tgcccgaatg cctcagattc      420

gtacaaacta atatctccca tctcctcaag gacacatgca cccagttgct cgcgttgaag      480

ccgtgcatcg ggaaagcatg tcagaacttc tcccgctgcc ttgaggtaca gtgccagccc      540

gattcctcga cgcttcttcc cccgagatcg cctattgcct tggaggccac ggagctgccc      600

gaacctcgac cgcgccagtt gctgctcctc ctgttgctct tgcttccgct tacactcgtg      660

ctgctggctg cagcgtgggg attgaggtgg cagagggcta ggcggagagg cgagctgcat      720

ccgggagtgc cattgccgtc gcacccatga taa                                   753


<210>  8
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3L

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Thr Val Leu Ala Pro Ala Trp Ser Pro Asn Ser Ser Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Ser Pro Cys Leu Arg Gly Thr Pro Asp Cys 
        35                  40                  45              


Tyr Phe Ser His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe Arg 
    50                  55                  60                  


Glu Leu Thr Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala Val 
65                  70                  75                  80  


Asn Leu Gln Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe Leu 
                85                  90                  95      


Ala Gln Arg Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys Met 
            100                 105                 110         


Gln Thr Leu Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr Ser 
        115                 120                 125             


Cys Thr Phe Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr Asn 
    130                 135                 140                 


Ile Ser His Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu Lys 
145                 150                 155                 160 


Pro Cys Ile Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu Val 
                165                 170                 175     


Gln Cys Gln Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro Ile 
            180                 185                 190         


Ala Leu Glu Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu Leu 
        195                 200                 205             


Leu Leu Leu Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala Ala 
    210                 215                 220                 


Ala Trp Gly Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu His 
225                 230                 235                 240 


Pro Gly Val Pro Leu Pro Ser His Pro 
                245                 


<210>  9
<211>  803
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TWEAK

<400>  9
atggattgga cttggatctt atttttagtt gctgctgcta ctagagttca ttctgccgca       60

agacggagtc agcgaagacg gggaagaagg ggagaacctg gcaccgcact gctggcacct      120

ctggtcctga gcctgggact ggctctggca tgcctggggc tgctgctggt ggtcgtgtct      180

ctgggcagtt gggcaactct gtcagcccag gagccaagcc aggaggaact gaccgccgaa      240

gacaggagag agccccctga actgaaccct cagaccgagg aatcccagga tgtcgtgcca      300

ttcctggagc agctggtccg accacggcgc tctgccccaa agggacgaaa agctcgaccc      360

cgaagggcaa tcgccgctca ctacgaggtg catccacgac caggacagga cggagcacag      420

gctggagtcg atggcaccgt gagcggatgg gaggaaacaa agattaacag ctcctctcct      480

ctgagatatg acagacagat cggcgagttc acagtgatta gagcaggact gtactatctg      540

tactgtcagg tccactttga cgaaggaaag gccgtgtacc tgaaactggt ctgctggtca      600

atggggtgct ggccctgcga tgcctggagg agttcagcgc cacagcagcc agttcacctg      660

gaccacagct gcgactgtgc caggtgtctg gactgctgcc actgcgacct gggagctccc      720

tgagaatccg gactctgccc tgggctcatc tgaaggctgc tccatttctg acatactttg      780

ggctgttcca ggtccactaa tga                                              803


<210>  10
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TWEAK

<400>  10

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu 
            20                  25                  30          


Pro Gly Thr Ala Leu Leu Ala Pro Leu Val Leu Ser Leu Gly Leu Ala 
        35                  40                  45              


Leu Ala Cys Leu Gly Leu Leu Leu Val Val Val Ser Leu Gly Ser Trp 
    50                  55                  60                  


Ala Thr Leu Ser Ala Gln Glu Pro Ser Gln Glu Glu Leu Thr Ala Glu 
65                  70                  75                  80  


Asp Arg Arg Glu Pro Pro Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln 
                85                  90                  95      


Asp Val Val Pro Phe Leu Glu Gln Leu Val Arg Pro Arg Arg Ser Ala 
            100                 105                 110         


Pro Lys Gly Arg Lys Ala Arg Pro Arg Arg Ala Ile Ala Ala His Tyr 
        115                 120                 125             


Glu Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp 
    130                 135                 140                 


Gly Thr Val Ser Gly Trp Glu Glu Thr Lys Ile Asn Ser Ser Ser Pro 
145                 150                 155                 160 


Leu Arg Tyr Asp Arg Gln Ile Gly Glu Phe Thr Val Ile Arg Ala Gly 
                165                 170                 175     


Leu Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val 
            180                 185                 190         


Tyr Leu Lys Leu Val Cys Trp Ser Met Gly Cys Trp Pro Cys Asp Ala 
        195                 200                 205             


Trp Arg Ser Ser Ala Pro Gln Gln Pro Val His Leu Asp His Ser Cys 
    210                 215                 220                 


Asp Cys Ala Arg Cys Leu Asp Cys Cys His Cys Asp Leu Gly Ala Pro 
225                 230                 235                 240 


<210>  11
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GITRL

<400>  11
atggattgga cttggatctt atttttagtt gctgctgcta ctagagttca ttctgaagaa       60

atgcccctga gagaatcaag tccccagaga gctgagaggt gtaagaagtc ctggctgctg      120

tgcatcgtcg ccctgctgct gatgctgctg tgcagtctgg gaactctgat ctacacctca      180

ctgaaaccta cagccattga gagctgtatg gtgaagttcg aactgagctc ctctaaatgg      240

cacatgacta gtcccaagcc tcattgcgtg aacaccacat ccgacgggaa gctgaaaatc      300

ctgcagtctg ggacctacct gatctatggc caggtcatcc cagtcgacaa gaaatacatc      360

aaggataatg cccccttcgt ggtccagatc tacaagaaaa acgacgtgct gcagacactg      420

atgaatgatt ttcagatcct gcccattggc ggagtctacg agctgcacgc tggcgacaac      480

atctatctga agtttaattc caaggatcat attcagaaaa caaacaccta ttgggggatt      540

atcctgatgc cagacctgcc cttcattagc taatga                                576


<210>  12
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GITRL

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Glu Met Pro Leu Arg Glu Ser Ser Pro Gln Arg Ala Glu 
            20                  25                  30          


Arg Cys Lys Lys Ser Trp Leu Leu Cys Ile Val Ala Leu Leu Leu Met 
        35                  40                  45              


Leu Leu Cys Ser Leu Gly Thr Leu Ile Tyr Thr Ser Leu Lys Pro Thr 
    50                  55                  60                  


Ala Ile Glu Ser Cys Met Val Lys Phe Glu Leu Ser Ser Ser Lys Trp 
65                  70                  75                  80  


His Met Thr Ser Pro Lys Pro His Cys Val Asn Thr Thr Ser Asp Gly 
                85                  90                  95      


Lys Leu Lys Ile Leu Gln Ser Gly Thr Tyr Leu Ile Tyr Gly Gln Val 
            100                 105                 110         


Ile Pro Val Asp Lys Lys Tyr Ile Lys Asp Asn Ala Pro Phe Val Val 
        115                 120                 125             


Gln Ile Tyr Lys Lys Asn Asp Val Leu Gln Thr Leu Met Asn Asp Phe 
    130                 135                 140                 


Gln Ile Leu Pro Ile Gly Gly Val Tyr Glu Leu His Ala Gly Asp Asn 
145                 150                 155                 160 


Ile Tyr Leu Lys Phe Asn Ser Lys Asp His Ile Gln Lys Thr Asn Thr 
                165                 170                 175     


Tyr Trp Gly Ile Ile Leu Met Pro Asp Leu Pro Phe Ile Ser 
            180                 185                 190 


<210>  13
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STING

<400>  13
ggatccgcca ccatggactg gacctggatt ctgttcctgg tcgccgctgc cacccgcgtg       60

cattcacctt actcaaacct gcaccctgcc attccccgac ccagaggaca ccggtcaaag      120

tacgtggctc tgatcttcct ggtcgcaagc ctgatgattc tgtgggtggc taaggaccct      180

cccaaccata ccctgaaata tctggctctg cacctggcat cccatgagct ggggctgctg      240

ctgaagaatc tgtgctgtct ggccgaggaa ctgtgccacg tgcagagtag gtaccaggga      300

tcatattgga aagcagtcag agcctgcctg gggtgtccta tccattgtat ggcaatgatt      360

ctgctgagct cctacttcta ttttctgcag aacaccgccg atatctacct gtcctggatg      420

ttcggcctgc tggtgctgta taagtctctg agtatgctgc tgggactgca gagcctgaca      480

cctgccgagg tgtccgctgt ctgcgaggaa aagaaactga acgtggcaca cggactggcc      540

tggtcttact atatcgggta cctgcggctg attctgccag gcctgcaggc tcggattcgc      600

atgtttaatc agctgcataa caatatgctg tccggcgcag gatctaggag actgtatatc      660

ctgttcccac tggactgcgg ggtgcccgat aacctgtctg tggtcgaccc taatattagg      720

ttcagggata tgctgccaca gcagaacatc gaccgagccg gcattaagaa ccgcgtgtac      780

tcaaatagcg tctatgagat cctggaaaat gggcagcccg caggcgtgtg cattctggag      840

tacgccaccc ctctgcagac actgttcgct atgtctcagg acgccaaggc tggcttcagc      900

agggaggatc gactggaaca ggccaaactg ttctgccgca cactggagga aatcctggag      960

gacgtgccag aaagtcggaa caattgtcgc ctgattgtct accaggagcc cactgatggc     1020

aactcctttt ctctgagtca ggaagtgctg aggcacatca gacaggagga aaaagaggaa     1080

gtcactatga atgcaccaat gaccagcgtg gctccacccc cttcagtcct gagccaggaa     1140

ccacgcctgc tgattagcgg aatggaccag ccactgccac tgcgaactga cctgatttga     1200

taactcgag                                                             1209


<210>  14
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STING

<400>  14

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Pro Tyr Ser Asn Leu His Pro Ala Ile Pro Arg Pro Arg Gly 
            20                  25                  30          


His Arg Ser Lys Tyr Val Ala Leu Ile Phe Leu Val Ala Ser Leu Met 
        35                  40                  45              


Ile Leu Trp Val Ala Lys Asp Pro Pro Asn His Thr Leu Lys Tyr Leu 
    50                  55                  60                  


Ala Leu His Leu Ala Ser His Glu Leu Gly Leu Leu Leu Lys Asn Leu 
65                  70                  75                  80  


Cys Cys Leu Ala Glu Glu Leu Cys His Val Gln Ser Arg Tyr Gln Gly 
                85                  90                  95      


Ser Tyr Trp Lys Ala Val Arg Ala Cys Leu Gly Cys Pro Ile His Cys 
            100                 105                 110         


Met Ala Met Ile Leu Leu Ser Ser Tyr Phe Tyr Phe Leu Gln Asn Thr 
        115                 120                 125             


Ala Asp Ile Tyr Leu Ser Trp Met Phe Gly Leu Leu Val Leu Tyr Lys 
    130                 135                 140                 


Ser Leu Ser Met Leu Leu Gly Leu Gln Ser Leu Thr Pro Ala Glu Val 
145                 150                 155                 160 


Ser Ala Val Cys Glu Glu Lys Lys Leu Asn Val Ala His Gly Leu Ala 
                165                 170                 175     


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Gly Leu Gln 
            180                 185                 190         


Ala Arg Ile Arg Met Phe Asn Gln Leu His Asn Asn Met Leu Ser Gly 
        195                 200                 205             


Ala Gly Ser Arg Arg Leu Tyr Ile Leu Phe Pro Leu Asp Cys Gly Val 
    210                 215                 220                 


Pro Asp Asn Leu Ser Val Val Asp Pro Asn Ile Arg Phe Arg Asp Met 
225                 230                 235                 240 


Leu Pro Gln Gln Asn Ile Asp Arg Ala Gly Ile Lys Asn Arg Val Tyr 
                245                 250                 255     


Ser Asn Ser Val Tyr Glu Ile Leu Glu Asn Gly Gln Pro Ala Gly Val 
            260                 265                 270         


Cys Ile Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
        275                 280                 285             


Gln Asp Ala Lys Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
    290                 295                 300                 


Lys Leu Phe Cys Arg Thr Leu Glu Glu Ile Leu Glu Asp Val Pro Glu 
305                 310                 315                 320 


Ser Arg Asn Asn Cys Arg Leu Ile Val Tyr Gln Glu Pro Thr Asp Gly 
                325                 330                 335     


Asn Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Ile Arg Gln Glu 
            340                 345                 350         


Glu Lys Glu Glu Val Thr Met Asn Ala Pro Met Thr Ser Val Ala Pro 
        355                 360                 365             


Pro Pro Ser Val Leu Ser Gln Glu Pro Arg Leu Leu Ile Ser Gly Met 
    370                 375                 380                 


Asp Gln Pro Leu Pro Leu Arg Thr Asp Leu Ile 
385                 390                 395 


