
                                SEQUENCE LISTING

<110> MILICH, David R.
      WHITACRE, David C.
      

<120> RODENT HEPADNAVIRUS CORES WITH REDUCED
  CARRIER-SPECIFIC ANTIGENICITY
  

<130> 720222000140

<140> PCT/US2014/029327   
<141> 2014-03-14  

<150> US 61/852,099       
<151> 2013-03-15  

<160> 32

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 188
<212> PRT
<213> Woodchuck hepatitis virus

<400> 1
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Leu Asp Phe Phe Pro Asp Leu Asn Ala Leu Val Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Cys Trp Asp Glu
    50                  55                  60                  
Leu Thr Lys Leu Ile Ala Trp Met Ser Ser Asn Ile Thr Ser Glu Gln
65                  70                  75                  80  
Val Arg Thr Ile Ile Val Asn His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Arg Arg Arg Gly Gly Ala Arg Ala Ser Arg Ser
145                 150                 155                 160 
Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro
                165                 170                 175     
Arg Arg Arg Arg Ser Gln Ser Pro Ser Ala Asn Cys
            180                 185             


<210> 2
<211> 188
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 2
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Ala Asp Phe Phe Pro Ala Ala Ala Val Leu Ala Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Cys Trp Asp Glu
    50                  55                  60                  
Leu Thr Lys Leu Ile Ala Trp Met Ser Ser Asn Ile Thr Ser Glu Gln
65                  70                  75                  80  
Val Arg Thr Ile Ile Val Asn His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Arg Arg Arg Gly Gly Ala Arg Ala Ser Arg Ser
145                 150                 155                 160 
Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro
                165                 170                 175     
Arg Arg Arg Arg Ser Gln Ser Pro Ser Ala Asn Cys
            180                 185             


<210> 3
<211> 188
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 3
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Leu Asp Phe Phe Pro Asp Leu Asn Ala Leu Val Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Cys Trp Asp Glu
    50                  55                  60                  
Leu Thr Lys Leu Ile Ala Trp Met Ser Ser Asn Ile Thr Ser Glu Gln
65                  70                  75                  80  
Val Arg Thr Ile Ile Val Asn His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Pro Pro Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Arg Arg Arg Gly Gly Ala Arg Ala Ser Arg Ser
145                 150                 155                 160 
Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro
                165                 170                 175     
Arg Arg Arg Arg Ser Gln Ser Pro Ser Ala Asn Cys
            180                 185             


<210> 4
<211> 188
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 4
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Leu Asp Phe Phe Pro Asp Leu Asn Ala Leu Val Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Ser Trp Asp Glu
    50                  55                  60                  
Leu Thr Lys Leu Ile Ala Trp Met Ser Ser Asn Ile Thr Ser Glu Gln
65                  70                  75                  80  
Val Arg Thr Ile Ile Val Asn His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Arg Arg Arg Gly Gly Ala Arg Ala Ser Arg Ser
145                 150                 155                 160 
Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro
                165                 170                 175     
Arg Arg Arg Arg Ser Gln Ser Pro Ser Ala Asn Cys
            180                 185             


<210> 5
<211> 188
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<220> 
<221> VARIANT        
<222> 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76,
77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87
<223> Xaa = Any Amino Acid

<400> 5
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Leu Asp Phe Phe Pro Asp Leu Asn Ala Leu Val Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Cys Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
65                  70                  75                  80  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Arg Arg Arg Gly Gly Ala Arg Ala Ser Arg Ser
145                 150                 155                 160 
Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro
                165                 170                 175     
Arg Arg Arg Arg Ser Gln Ser Pro Ser Ala Asn Cys
            180                 185             


<210> 6
<211> 188
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 6
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Leu Asp Phe Phe Pro Asp Leu Asn Ala Leu Val Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Cys Trp Asp Glu
    50                  55                  60                  
Leu Thr Lys Leu Ile Ala Trp Met Ser Ser Asn Ile Thr Ser Glu Gln
65                  70                  75                  80  
Val Arg Thr Ile Ile Val Asn His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Ala Ala Ala Gly Gly Ala Ala Ala Ser Ala Ser
145                 150                 155                 160 
Pro Ala Ala Ala Thr Pro Ser Pro Ala Ala Ala Arg Ser Gln Ser Pro
                165                 170                 175     
Ala Ala Ala Ala Ser Gln Ser Pro Ser Ala Asn Cys
            180                 185             


<210> 7
<211> 188
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 7
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Leu Asp Phe Phe Pro Asp Leu Asn Ala Leu Val Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Cys Trp Asp Glu
    50                  55                  60                  
Leu Thr Lys Leu Ile Ala Trp Met Ser Ser Ala Ala Ala Ala Ala Ala
65                  70                  75                  80  
Ala Ala Ala Ile Ile Val Asn His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Arg Arg Arg Gly Gly Ala Arg Ala Ser Arg Ser
145                 150                 155                 160 
Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro
                165                 170                 175     
Arg Arg Arg Arg Ser Gln Ser Pro Ser Ala Asn Cys
            180                 185             


<210> 8
<211> 187
<212> PRT
<213> Ground Squirrel Hepatitis Virus

<400> 8
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Leu Asp Phe Phe Pro Asp Leu Asn Ala Leu Val Asp
            20                  25                  30          
Thr Ala Ala Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Cys Trp Glu Glu
    50                  55                  60                  
Leu Thr Arg Leu Ile Thr Trp Met Ser Glu Asn Thr Thr Glu Glu Val
65                  70                  75                  80  
Arg Arg Ile Ile Val Asp His Val Asn Asp Thr Trp Gly Leu Lys Val
                85                  90                  95      
Arg Gln Thr Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln His
            100                 105                 110         
Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro
        115                 120                 125             
Ala Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu
    130                 135                 140                 
His Thr Val Ile Arg Arg Arg Gly Gly Ser Arg Ala Ala Arg Ser Pro
145                 150                 155                 160 
Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg
                165                 170                 175     
Arg Arg Arg Ser Gln Ser Pro Ala Ser Asn Cys
            180                 185         


<210> 9
<211> 187
<212> PRT
<213> Arctic Ground Squirrel Hepatitis Virus

<400> 9
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Leu Asp Phe Phe Pro Glu Leu Asn Ala Leu Val Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Cys Trp Glu Glu
    50                  55                  60                  
Leu Thr Arg Leu Ile Ala Trp Met Ser Ala Asn Ile Asn Ser Glu Glu
65                  70                  75                  80  
Val Arg Arg Val Ile Val Ala His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Asn Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Arg Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Arg Arg Arg Gly Ser Ala Arg Val Val Arg Ser
145                 150                 155                 160 
Pro Arg Arg Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro
                165                 170                 175     
Arg Arg Arg Arg Gln Ser Pro Ala Ser Asn Cys
            180                 185         


<210> 10
<211> 183
<212> PRT
<213> Human Hepatitis B Virus

<400> 10
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu
 1               5                  10                  15      
Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp
            20                  25                  30          
Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu
    50                  55                  60                  
Leu Met Thr Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala
65                  70                  75                  80  
Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys
                85                  90                  95      
Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg
            100                 105                 110         
Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr
145                 150                 155                 160 
Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser
                165                 170                 175     
Gln Ser Arg Glu Ser Gln Cys
            180             


<210> 11
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 11
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Leu Asp Phe Phe Pro Asp Leu Asn Ala Leu Val Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Cys Trp Asp Glu
    50                  55                  60                  
Leu Thr Lys Leu Ile Ala Trp Met Ser Ser Asn Ile Thr Ser Glu Gln
65                  70                  75                  80  
Val Arg Thr Ile Ile Val Asn His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile
145                 


<210> 12
<211> 188
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<220> 
<221> VARIANT        
<222> (1)...(188)
<223> Xaa = Any Amino Acid or Absent


<400> 12
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Xaa Asp Phe Phe Pro Xaa Xaa Xaa Xaa Leu Xaa Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
65                  70                  75                  80  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Xaa Xaa Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
145                 150                 155                 160 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                165                 170                 175     
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            180                 185             


<210> 13
<211> 188
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<220> 
<221> VARIANT        
<222> (1)...(188)
<223> Xaa = Any Amino Acid or Absent

<400> 13
Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ser Ser Tyr Gln Leu Leu
 1               5                  10                  15      
Asn Phe Leu Pro Xaa Asp Phe Phe Pro Xaa Xaa Xaa Xaa Leu Xaa Asp
            20                  25                  30          
Thr Ala Thr Ala Leu Tyr Glu Glu Glu Leu Thr Gly Arg Glu His Cys
        35                  40                  45              
Ser Pro His His Thr Ala Ile Arg Gln Ala Leu Val Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
65                  70                  75                  80  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Val Asn Asp Thr Trp Gly Leu Lys
                85                  90                  95      
Val Arg Gln Ser Leu Trp Phe His Leu Ser Cys Leu Thr Phe Gly Gln
            100                 105                 110         
His Thr Val Gln Glu Phe Leu Val Ser Phe Gly Val Trp Ile Arg Thr
        115                 120                 125             
Pro Ala Pro Tyr Arg Pro Pro Xaa Xaa Pro Ile Leu Ser Thr Leu Pro
    130                 135                 140                 
Glu His Thr Val Ile Xaa Xaa Xaa Gly Gly Ala Xaa Ala Ser Xaa Ser
145                 150                 155                 160 
Pro Xaa Xaa Xaa Thr Pro Ser Pro Xaa Xaa Xaa Arg Ser Gln Ser Pro
                165                 170                 175     
Xaa Xaa Xaa Xaa Ser Gln Ser Pro Ser Ala Asn Cys
            180                 185             


<210> 14
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 14
Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro
 1               5                  10                  15      
Asn Ala Asn Pro
            20  


<210> 15
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 15
Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp
 1               5                  10                  15      
Gln Lys Lys Leu Met Ser Asn Asn
            20                  


<210> 16
<211> 3323
<212> DNA
<213> Woodchuck hepatitis virus

<400> 16
aattcgggac ataccacgtg gtttagttcc gcctcaaact ccaacaaatc gagatcaagg 60
gagaaagcct actcctccaa ctccacctct aagagatact cacccccact taactatgaa 120
aaatcagact tttcatctcc aggggttcgt agacggatta cgagacttga caacaacgga 180
acgccaacac aatgcctatg gagatccttt tacaacacta agccctgcgg ttcctactgt 240
atccaccata ttgtctcctc cctcgacgac tggggaccct gcactgtcac cggagatgtc 300
accatcaagt ctcctaggac tcctcgcagg attacaggtg gtgtatttct tgtggacaaa 360
aatcctaaca atagctcaga atctagattg gtggtggact tctctcagtt ttccaggggg 420
cataccagag tgcactggcc aaaattcgca gttccaaact tgcaaacact tgccaacctc 480
ctgtccacca acttgcaatg gctttcgttg gatgtatctg cggcgtttta tcatatacct 540
attagtcctg ctgctgtgcc tcatcttctt gttggttctc ctggactgga aaggtttaat 600
acctgtctgt cctcttcaac ccacaacaga aacaacagtc aattgcagac aatgcacaat 660
ctctgcacaa gacatgtata ctcctcctta ctgttgttgt ttaaaaccta cggcaggaaa 720
ttgcacttgt tggcccatcc cttcatcatg ggctttagga aattacctat gggagtgggc 780
cttagcccgt ttctcttggc tcaatttact agtgcccttg cttcaatggt taggaggaat 840
ttccctcatt gcgtggtttt tgcttatatg gatgatttgg ttttgggggc ccgcacttct 900
gagcatctta ccgccattta ttcccatatt tgttctgttt ttcttgattt gggtatacat 960
ttgaatgtca ataaaacaaa atggtggggc aatcatctac atttcatggg atatgtgatt 1020
actagttcag gtgtattgcc acaagacaaa catgttaaga aaatttcccg ttatttgcgc 1080
tctgttcctg ttaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt 1140
aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct 1200
attacttccc gtacggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt 1260
tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac 1320
gcaaccccca ctggttgggg cattgccacc acctatcaac tcctttccgg gactttcgct 1380
ttccccctcc ctattgccac ggcggaactc attgccgcct gccttgcccg ctgctggaca 1440
ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaagct gacgtccttt 1500
ccatggctgc tcgcctgtgt tgccaactgg attctgcgcg ggacgtcctt ctgctacgtc 1560
ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggt tctgcggcct 1620
cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg 1680
cctgtttcgc ctcggcgtcc ggtccgtgtt gcttggtctt cacctgtgca gaattgcgaa 1740
ccatggattc caccgtgaac tttgtctcct ggcatgcaaa tcgtcaactt ggcatgccaa 1800
gtaaggacct ttggactcct tatataaaag atcaattatt aactaaatgg gaggagggca 1860
gcattgatcc tagattatca atatttgtat taggaggctg taggcataaa tgcatgcgac 1920
ttctgtaacc atgtatcttt ttcacctgtg ccttgttttt gcctgtgttc catgtcctac 1980
ttttcaagcc tccaagctgt gccttggatg gctttggggc atggacatag atccctataa 2040
agaatttggt tcatcttatc agttgttgaa ttttcttcct ttggacttct ttcctgacct 2100
taatgctttg gtggacactg ctactgcctt gtatgaagaa gagctaacag gtagggaaca 2160
ttgctctccg caccatacag ctattagaca agctttagta tgctgggatg aattaactaa 2220
attgatagct tggatgagct ctaacataac ttctgaacaa gtaagaacaa tcatagtaaa 2280
tcatgtcaat gatacctggg gacttaaggt gagacaaagt ttatggtttc atttgtcatg 2340
tctcactttt ggacaacata cagttcaaga atttttagta agttttggag tatggatcag 2400
aactccagct ccatatagac ctcctaatgc acccattctc tcgactcttc cggaacatac 2460
agtcattagg agaagaggag gtgcaagagc ttctaggtcc cccagaagac gcactccctc 2520
tcctcgcagg agaagatctc aatcaccgcg tcgcagacgc tctcaatctc catctgccaa 2580
ctgctgatct tcaatgggta cataaaacta atgctattac aggtctttac tctaaccaag 2640
ctgctcagtt caatccgcat tggattcaac ctgagtttcc tgaacttcat ttacataatg 2700
atttaattca aaaattgcaa cagtattttg gtcctttgac tataaatgaa aagagaaaat 2760
tgcaattaaa ttttcctgcc agatttttcc ccaaagctac taaatatttc cctttaatta 2820
aaggcataaa aaacaattat cctaattttg ctttagaaca tttctttgct accgcaaatt 2880
atttgtggac tttatgggaa gctggaattt tgtatttaag gaagaatcaa acaactttga 2940
cttttaaagg taaaccatat tcttgggaac acagacagct agtgcaacat aatgggcaac 3000
aacataaaag tcaccttcaa tccagacaaa atagcagcat ggtggcctgc agtgggcact 3060
tattacacaa ccacttatcc tcagaatcag tcagtgtttc aaccaggaat ttatcaaaca 3120
acatctctga taaatcccaa aaatcaacaa gaactggact ctgttcttat aaacagatac 3180
aaacagatag actggaacac ttggcaagga tttcctgtgg atcaaaaatt accattggtc 3240
agcagggatc ctcccccaaa accttatata aatcaatcag ctcaaacttt cgaaatcaaa 3300
cctgggccta taatagttcc cgg                                         3323

<210> 17
<211> 65
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<220> 
<221> VARIANT        
<222> (5)...(64)
<223> Xaa = Any Amino Acid and up to 60 of them can be 
      present or absent

<400> 17
Gly Ile Leu Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        35                  40                  45              
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Leu
65  


<210> 18
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 18
Trp Leu Trp Gly
 1              


<210> 19
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 19
Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu
 1               5                  10          


<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 20
Ala Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu
 1               5                  10          


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 21
Pro Ala Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu
 1               5                  10          


<210> 22
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 22
Pro Pro Phe Tyr Arg Pro Pro Asn Ala Pro Ile Leu
 1               5                  10          


<210> 23
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 23
Pro Pro Ala Ala Arg Pro Pro Asn Ala Pro Ile Leu
 1               5                  10          


<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 24
Pro Pro Ala Tyr Ala Pro Pro Asn Ala Pro Ile Leu
 1               5                  10          


<210> 25
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 25
Pro Pro Ala Tyr Arg Ala Pro Asn Ala Pro Ile Leu
 1               5                  10          


<210> 26
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 26
Pro Pro Ala Tyr Arg Pro Ala Asn Ala Pro Ile Leu
 1               5                  10          


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 27
Pro Pro Ala Tyr Arg Pro Pro Ala Ala Pro Ile Leu
 1               5                  10          


<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 28
Pro Pro Ala Tyr Arg Pro Pro Asn Phe Pro Ile Leu
 1               5                  10          


<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 29
Pro Pro Ala Tyr Arg Pro Pro Asn Ala Ala Ile Leu
 1               5                  10          


<210> 30
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 30
Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ala Leu
 1               5                  10          


<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 31
Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Ala
 1               5                  10          


<210> 32
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Construct

<400> 32
Pro Pro Ala Tyr Arg Pro Pro Pro Pro Pro Ile Leu
 1               5                  10          

