                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> INCREASING SPECIFICITY FOR RNA-GUIDED GENOME EDITING

<130> 00786-0897WO1

<140> PCT/US2014/029304
<141> 2014-03-14

<150> 61/921,007
<151> 2013-12-26

<150> 61/838,178
<151> 2013-06-21

<150> 61/838,148
<151> 2013-06-21

<150> 61/799,647
<151> 2013-03-15

<160> 107    

<170> PatentIn version 3.5

<210> 1
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding site oligonucleotide

<400> 1
gggcacgggc agcttgccgg tgg                                               23


<210> 2
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding site oligonucleotide

<400> 2
gatgccgttc ttctgcttgt cgg                                               23


<210> 3
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding site oligonucleotide

<400> 3
ggtggtgcag atgaacttca ggg                                               23


<210> 4
<211> 242
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<220>
<221> modified_base
<222> (43)..(242)
<223> a, c, u, g, unknown or other and this region may encompass
      0-200 nucleotides

<400> 4
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu ugnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nn                                                                     242


<210> 5
<211> 32
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA oligonucleotide 


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 5
nnnnnnnnnn nnnnnnnnnn guuuuagagc ua                                     32


<210> 6
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA oligonucleotide 


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 6
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu ug                          42


<210> 7
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA oligonucleotide 


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 7
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcu                                 36


<210> 8
<211> 262
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<220>
<221> modified_base
<222> (63)..(262)
<223> a, c, u, g, unknown or other and this region may encompass
      0-200 nucleotides

<400> 8
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nn                                               262


<210> 9
<211> 275
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<220>
<221> modified_base
<222> (76)..(275)
<223> a, c, u, g, unknown or other and this region may encompass
      0-200 nucleotides

<400> 9
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcugaaa agcauagcaa guuaaaauaa       60

ggcuaguccg uuaucnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnn                                 275


<210> 10
<211> 287
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<220>
<221> modified_base
<222> (88)..(287)
<223> a, c, u, g, unknown or other and this region may encompass
      0-200 nucleotides

<400> 10
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu uggaaacaaa acagcauagc       60

aaguuaaaau aaggcuaguc cguuaucnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                    287


<210> 11
<211> 296
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<220>
<221> modified_base
<222> (97)..(296)
<223> a, c, u, g, unknown or other and this region may encompass
      0-200 nucleotides

<400> 11
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnn          296


<210> 12
<211> 96
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA oligonucleotide 


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 12
nnnnnnnnnn nnnnnnnnnn guuuaagagc uagaaauagc aaguuuaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210> 13
<211> 106
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 13
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuggaa acagcauagc aaguuuaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugc                     106


<210> 14
<211> 106
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 14
nnnnnnnnnn nnnnnnnnnn guuuaagagc uaugcuggaa acagcauagc aaguuuaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugc                     106


<210> 15
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA oligonucleotide 

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      guide RNA oligonucleotide 

<400> 15
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagt cggugcuuuu                                                   80


<210> 16
<211> 60
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA oligonucleotide 

<400> 16
uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc gagucggugc       60


<210> 17
<211> 64
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA oligonucleotide 

<400> 17
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugc                                                                    64


<210> 18
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 18
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 19
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding oligonucleotide

<400> 19
aaacaugagg auuacccaug ucg                                               23


<210> 20
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding oligonucleotide

<400> 20
aaacaugagg aucacccaug ucg                                               23


<210> 21
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding oligonucleotide

<400> 21
gcccugaaga agggc                                                        15


<210> 22
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding oligonucleotide

<400> 22
gcccugaaaa agggc                                                        15


<210> 23
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding oligonucleotide

<400> 23
guucacugcc guauaggcag                                                   20


<210> 24
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding oligonucleotide

<400> 24
guucacugcc guauaggcag cuaagaaa                                          28


<210> 25
<211> 130
<212> PRT
<213> Enterobacteria phage MS2

<220>
<223> MS2 coat polypeptide

<400> 25
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210> 26
<211> 130
<212> PRT
<213> Enterobacteria phage MS2

<220>
<223> MS2 N55K polypeptide

<400> 26
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210> 27
<211> 117
<212> PRT
<213> Enterobacteria phage MS2

<220>
<223> MS2deltaFG polypeptide

<400> 27
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr 
        115         


<210> 28
<211> 262
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      dimeric MS2 coat polypeptide

<400> 28
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Leu Tyr Gly Ala Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp 
    130                 135                 140                 


Asn Gly Gly Thr Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn 
145                 150                 155                 160 


Gly Val Ala Glu Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys 
                165                 170                 175     


Val Thr Cys Ser Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr 
            180                 185                 190         


Ile Lys Val Glu Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val 
        195                 200                 205             


Glu Leu Pro Val Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr 
    210                 215                 220                 


Ile Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala 
225                 230                 235                 240 


Met Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala 
                245                 250                 255     


Ala Asn Ser Leu Ile Asn 
            260         


<210> 29
<211> 262
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      dimeric MS2 N55K polypeptide

<400> 29
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Leu Tyr Gly Ala Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp 
    130                 135                 140                 


Asn Gly Gly Thr Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn 
145                 150                 155                 160 


Gly Val Ala Glu Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys 
                165                 170                 175     


Val Thr Cys Ser Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr 
            180                 185                 190         


Ile Lys Val Glu Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val 
        195                 200                 205             


Glu Leu Pro Val Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr 
    210                 215                 220                 


Ile Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala 
225                 230                 235                 240 


Met Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala 
                245                 250                 255     


Ala Asn Ser Leu Ile Asn 
            260         


<210> 30
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      dimeric MS2deltaFG polypeptide

<400> 30
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Leu Tyr Gly Ala Met Ala Ser Asn Phe Thr Gln Phe Val 
        115                 120                 125             


Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr Val Ala Pro Ser Asn 
    130                 135                 140                 


Phe Ala Asn Gly Val Ala Glu Trp Ile Ser Ser Asn Ser Arg Ser Gln 
145                 150                 155                 160 


Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser Ser Ala Gln Lys Arg 
                165                 170                 175     


Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Gly Ala Trp Arg Ser Tyr 
            180                 185                 190         


Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn Ser Asp Cys 
        195                 200                 205             


Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp Gly Asn Pro 
    210                 215                 220                 


Ile Pro Ser Ala Ile Ala Ala Asn Ser Leu Ile Asn 
225                 230                 235     


<210> 31
<211> 22
<212> PRT
<213> Enterobacteria phage lambda N

<400> 31
Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn 
            20          


<210> 32
<211> 107
<212> PRT
<213> Enterobacteria phage lambda N

<400> 32
Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn Pro Leu Leu Val Gly Val Ser Ala Lys Pro 
            20                  25                  30          


Val Asn Arg Pro Ile Leu Ser Leu Asn Arg Lys Pro Lys Ser Arg Val 
        35                  40                  45              


Glu Ser Ala Leu Asn Pro Ile Asp Leu Thr Val Leu Ala Glu Tyr His 
    50                  55                  60                  


Lys Gln Ile Glu Ser Asn Leu Gln Arg Ile Glu Arg Lys Asn Gln Arg 
65                  70                  75                  80  


Thr Trp Tyr Ser Lys Pro Gly Glu Arg Gly Ile Thr Cys Ser Gly Arg 
                85                  90                  95      


Gln Lys Ile Lys Gly Lys Ser Ile Pro Leu Ile 
            100                 105         


<210> 33
<211> 583
<212> PRT
<213> Planomicrobium okeanokoites

<400> 33
Met Phe Leu Ser Met Val Ser Lys Ile Arg Thr Phe Gly Trp Val Gln 
1               5                   10                  15      


Asn Pro Gly Lys Phe Glu Asn Leu Lys Arg Val Val Gln Val Phe Asp 
            20                  25                  30          


Arg Asn Ser Lys Val His Asn Glu Val Lys Asn Ile Lys Ile Pro Thr 
        35                  40                  45              


Leu Val Lys Glu Ser Lys Ile Gln Lys Glu Leu Val Ala Ile Met Asn 
    50                  55                  60                  


Gln His Asp Leu Ile Tyr Thr Tyr Lys Glu Leu Val Gly Thr Gly Thr 
65                  70                  75                  80  


Ser Ile Arg Ser Glu Ala Pro Cys Asp Ala Ile Ile Gln Ala Thr Ile 
                85                  90                  95      


Ala Asp Gln Gly Asn Lys Lys Gly Tyr Ile Asp Asn Trp Ser Ser Asp 
            100                 105                 110         


Gly Phe Leu Arg Trp Ala His Ala Leu Gly Phe Ile Glu Tyr Ile Asn 
        115                 120                 125             


Lys Ser Asp Ser Phe Val Ile Thr Asp Val Gly Leu Ala Tyr Ser Lys 
    130                 135                 140                 


Ser Ala Asp Gly Ser Ala Ile Glu Lys Glu Ile Leu Ile Glu Ala Ile 
145                 150                 155                 160 


Ser Ser Tyr Pro Pro Ala Ile Arg Ile Leu Thr Leu Leu Glu Asp Gly 
                165                 170                 175     


Gln His Leu Thr Lys Phe Asp Leu Gly Lys Asn Leu Gly Phe Ser Gly 
            180                 185                 190         


Glu Ser Gly Phe Thr Ser Leu Pro Glu Gly Ile Leu Leu Asp Thr Leu 
        195                 200                 205             


Ala Asn Ala Met Pro Lys Asp Lys Gly Glu Ile Arg Asn Asn Trp Glu 
    210                 215                 220                 


Gly Ser Ser Asp Lys Tyr Ala Arg Met Ile Gly Gly Trp Leu Asp Lys 
225                 230                 235                 240 


Leu Gly Leu Val Lys Gln Gly Lys Lys Glu Phe Ile Ile Pro Thr Leu 
                245                 250                 255     


Gly Lys Pro Asp Asn Lys Glu Phe Ile Ser His Ala Phe Lys Ile Thr 
            260                 265                 270         


Gly Glu Gly Leu Lys Val Leu Arg Arg Ala Lys Gly Ser Thr Lys Phe 
        275                 280                 285             


Thr Arg Val Pro Lys Arg Val Tyr Trp Glu Met Leu Ala Thr Asn Leu 
    290                 295                 300                 


Thr Asp Lys Glu Tyr Val Arg Thr Arg Arg Ala Leu Ile Leu Glu Ile 
305                 310                 315                 320 


Leu Ile Lys Ala Gly Ser Leu Lys Ile Glu Gln Ile Gln Asp Asn Leu 
                325                 330                 335     


Lys Lys Leu Gly Phe Asp Glu Val Ile Glu Thr Ile Glu Asn Asp Ile 
            340                 345                 350         


Lys Gly Leu Ile Asn Thr Gly Ile Phe Ile Glu Ile Lys Gly Arg Phe 
        355                 360                 365             


Tyr Gln Leu Lys Asp His Ile Leu Gln Phe Val Ile Pro Asn Arg Gly 
    370                 375                 380                 


Val Thr Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu 
385                 390                 395                 400 


Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile 
                405                 410                 415     


Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val 
            420                 425                 430         


Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly 
        435                 440                 445             


Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile 
    450                 455                 460                 


Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn 
465                 470                 475                 480 


Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn 
                485                 490                 495     


Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr 
            500                 505                 510         


Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe 
        515                 520                 525             


Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn 
    530                 535                 540                 


Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu 
545                 550                 555                 560 


Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe 
                565                 570                 575     


Asn Asn Gly Glu Ile Asn Phe 
            580             


<210> 34
<211> 1752
<212> DNA
<213> Planomicrobium okeanokoites

<400> 34
atgtttttga gtatggtttc taaaataaga actttcggtt gggttcaaaa tccaggtaaa       60

tttgagaatt taaaacgagt agttcaagta tttgatagaa attctaaagt acataatgaa      120

gtgaaaaata taaagatacc aaccctagtc aaagaaagta agatccaaaa agaactagtt      180

gctattatga atcaacatga tttgatttat acatataaag agttagtagg aacaggaact      240

tcaatacgtt cagaagcacc atgcgatgca attattcaag caacaatagc agatcaagga      300

aataaaaaag gctatatcga taattggtca tctgacggtt ttttgcgttg ggcacatgct      360

ttaggattta ttgaatatat aaataaaagt gattcttttg taataactga tgttggactt      420

gcttactcta aatcagctga cggcagcgcc attgaaaaag agattttgat tgaagcgata      480

tcatcttatc ctccagcgat tcgtatttta actttgctag aagatggaca acatttgaca      540

aagtttgatc ttggcaagaa tttaggtttt agtggagaaa gtggatttac ttctctaccg      600

gaaggaattc ttttagatac tctagctaat gctatgccta aagataaagg cgaaattcgt      660

aataattggg aaggatcttc agataagtac gcaagaatga taggtggttg gctggataaa      720

ctaggattag taaagcaagg aaaaaaagaa tttatcattc ctactttggg taagccggac      780

aataaagagt ttatatccca cgcttttaaa attactggag aaggtttgaa agtactgcgt      840

cgagcaaaag gctctacaaa atttacacgt gtacctaaaa gagtatattg ggaaatgctt      900

gctacaaacc taaccgataa agagtatgta agaacaagaa gagctttgat tttagaaata      960

ttaatcaaag ctggatcatt aaaaatagaa caaatacaag acaacttgaa gaaattagga     1020

tttgatgaag ttatagaaac tattgaaaat gatatcaaag gcttaattaa cacaggtata     1080

tttatagaaa tcaaagggcg attttatcaa ttgaaagacc atattcttca atttgtaata     1140

cctaatcgtg gtgtgactaa gcaactagtc aaaagtgaac tggaggagaa gaaatctgaa     1200

cttcgtcata aattgaaata tgtgcctcat gaatatattg aattaattga aattgccaga     1260

aattccactc aggatagaat tcttgaaatg aaggtaatgg aattttttat gaaagtttat     1320

ggatatagag gtaaacattt gggtggatca aggaaaccgg acggagcaat ttatactgtc     1380

ggatctccta ttgattacgg tgtgatcgtg gatactaaag cttatagcgg aggttataat     1440

ctgccaattg gccaagcaga tgaaatgcaa cgatatgtcg aagaaaatca aacacgaaac     1500

aaacatatca accctaatga atggtggaaa gtctatccat cttctgtaac ggaatttaag     1560

tttttatttg tgagtggtca ctttaaagga aactacaaag ctcagcttac acgattaaat     1620

catatcacta attgtaatgg agctgttctt agtgtagaag agcttttaat tggtggagaa     1680

atgattaaag ccggcacatt aaccttagag gaagtgagac ggaaatttaa taacggcgag     1740

ataaactttt aa                                                         1752


<210> 35
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
gtaaaacgac ggccag                                                       16


<210> 36
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Csy4 RNA binding oligonucleotide

<400> 36
guucacugcc guauaggcag cuaagaaa                                          28


<210> 37
<211> 252
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      multiplex guide RNA polynucleotide


<220>
<221> modified_base
<222> (21)..(40)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (137)..(156)
<223> a, c, u, g, unknown or other

<400> 37
guucacugcc guauaggcag nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc       60

aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcguuc      120

acugccguau aggcagnnnn nnnnnnnnnn nnnnnnguuu uagagcuaga aauagcaagu      180

uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu gcguucacug      240

ccguauaggc ag                                                          252


<210> 38
<211> 1167
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Csy4-FokI N-terminal fusion polynucleotide

<400> 38
atggaccact acctcgacat tcgcttgcga ccggacccgg aatttccccc ggcgcaactc       60

atgagcgtgc tcttcggcaa gctccaccag gccctggtgg cacagggcgg ggacaggatc      120

ggcgtgagct tccccgacct cgacgaaagc cgctcccggc tgggcgagcg cctgcgcatt      180

catgcctcgg cggacgacct tcgtgccctg ctcgcccggc cctggctgga agggttgcgg      240

gaccatctgc aattcggaga accggcagtc gtgcctcacc ccacaccgta ccgtcaggtc      300

agtcgggttc aggcgaaaag caatccggaa cgcctgcggc ggcggctcat gcgccggcac      360

gatctgagtg aggaggaggc tcggaaacgc attcccgata cggtcgcgag agccttggac      420

ctgcccttcg tcacgctacg cagccagagc accggacagc acttccgtct cttcatccgc      480

cacgggccgt tgcaggtgac ggcagaggaa ggaggattca cctgttacgg gttgagcaaa      540

ggaggtttcg ttccctggtt cggtggcggt ggatcccaac tagtcaaaag tgaactggag      600

gagaagaaat ctgaacttcg tcataaattg aaatatgtgc ctcatgaata tattgaatta      660

attgaaattg ccagaaattc cactcaggat agaattcttg aaatgaaggt aatggaattt      720

tttatgaaag tttatggata tagaggtaaa catttgggtg gatcaaggaa accggacgga      780

gcaatttata ctgtcggatc tcctattgat tacggtgtga tcgtggatac taaagcttat      840

agcggaggtt ataatctgcc aattggccaa gcagatgaaa tgcaacgata tgtcgaagaa      900

aatcaaacac gaaacaaaca tatcaaccct aatgaatggt ggaaagtcta tccatcttct      960

gtaacggaat ttaagttttt atttgtgagt ggtcacttta aaggaaacta caaagctcag     1020

cttacacgat taaatcatat cactaattgt aatggagctg ttcttagtgt agaagagctt     1080

ttaattggtg gagaaatgat taaagccggc acattaacct tagaggaagt cagacggaaa     1140

tttaataacg gcgagataaa cttttga                                         1167


<210> 39
<211> 388
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Csy4-FokI N-terminal fusion polypeptide

<400> 39
Met Asp His Tyr Leu Asp Ile Arg Leu Arg Pro Asp Pro Glu Phe Pro 
1               5                   10                  15      


Pro Ala Gln Leu Met Ser Val Leu Phe Gly Lys Leu His Gln Ala Leu 
            20                  25                  30          


Val Ala Gln Gly Gly Asp Arg Ile Gly Val Ser Phe Pro Asp Leu Asp 
        35                  40                  45              


Glu Ser Arg Ser Arg Leu Gly Glu Arg Leu Arg Ile His Ala Ser Ala 
    50                  55                  60                  


Asp Asp Leu Arg Ala Leu Leu Ala Arg Pro Trp Leu Glu Gly Leu Arg 
65                  70                  75                  80  


Asp His Leu Gln Phe Gly Glu Pro Ala Val Val Pro His Pro Thr Pro 
                85                  90                  95      


Tyr Arg Gln Val Ser Arg Val Gln Ala Lys Ser Asn Pro Glu Arg Leu 
            100                 105                 110         


Arg Arg Arg Leu Met Arg Arg His Asp Leu Ser Glu Glu Glu Ala Arg 
        115                 120                 125             


Lys Arg Ile Pro Asp Thr Val Ala Arg Ala Leu Asp Leu Pro Phe Val 
    130                 135                 140                 


Thr Leu Arg Ser Gln Ser Thr Gly Gln His Phe Arg Leu Phe Ile Arg 
145                 150                 155                 160 


His Gly Pro Leu Gln Val Thr Ala Glu Glu Gly Gly Phe Thr Cys Tyr 
                165                 170                 175     


Gly Leu Ser Lys Gly Gly Phe Val Pro Trp Phe Gly Gly Gly Gly Ser 
            180                 185                 190         


Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
        195                 200                 205             


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
    210                 215                 220                 


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
225                 230                 235                 240 


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
                245                 250                 255     


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
            260                 265                 270         


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
        275                 280                 285             


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
    290                 295                 300                 


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
305                 310                 315                 320 


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
                325                 330                 335     


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
            340                 345                 350         


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
        355                 360                 365             


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
    370                 375                 380                 


Glu Ile Asn Phe 
385             


<210> 40
<211> 1167
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Csy4-FokI C-terminal fusion polynucleotide

<400> 40
atgcaactag tcaaaagtga actggaggag aagaaatctg aacttcgtca taaattgaaa       60

tatgtgcctc atgaatatat tgaattaatt gaaattgcca gaaattccac tcaggataga      120

attcttgaaa tgaaggtaat ggaatttttt atgaaagttt atggatatag aggtaaacat      180

ttgggtggat caaggaaacc ggacggagca atttatactg tcggatctcc tattgattac      240

ggtgtgatcg tggatactaa agcttatagc ggaggttata atctgccaat tggccaagca      300

gatgaaatgc aacgatatgt cgaagaaaat caaacacgaa acaaacatat caaccctaat      360

gaatggtgga aagtctatcc atcttctgta acggaattta agtttttatt tgtgagtggt      420

cactttaaag gaaactacaa agctcagctt acacgattaa atcatatcac taattgtaat      480

ggagctgttc ttagtgtaga agagctttta attggtggag aaatgattaa agccggcaca      540

ttaaccttag aggaagtcag acggaaattt aataacggcg agataaactt tggtggcggt      600

ggatccgacc actacctcga cattcgcttg cgaccggacc cggaatttcc cccggcgcaa      660

ctcatgagcg tgctcttcgg caagctccac caggccctgg tggcacaggg cggggacagg      720

atcggcgtga gcttccccga cctcgacgaa agccgctccc ggctgggcga gcgcctgcgc      780

attcatgcct cggcggacga ccttcgtgcc ctgctcgccc ggccctggct ggaagggttg      840

cgggaccatc tgcaattcgg agaaccggca gtcgtgcctc accccacacc gtaccgtcag      900

gtcagtcggg ttcaggcgaa aagcaatccg gaacgcctgc ggcggcggct catgcgccgg      960

cacgatctga gtgaggagga ggctcggaaa cgcattcccg atacggtcgc gagagccttg     1020

gacctgccct tcgtcacgct acgcagccag agcaccggac agcacttccg tctcttcatc     1080

cgccacgggc cgttgcaggt gacggcagag gaaggaggat tcacctgtta cgggttgagc     1140

aaaggaggtt tcgttccctg gttctga                                         1167


<210> 41
<211> 388
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Csy4-FokI C-terminal fusion polypeptide

<400> 41
Met Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
1               5                   10                  15      


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
            20                  25                  30          


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
        35                  40                  45              


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
    50                  55                  60                  


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
65                  70                  75                  80  


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
                85                  90                  95      


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
            100                 105                 110         


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
        115                 120                 125             


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
    130                 135                 140                 


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
145                 150                 155                 160 


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
                165                 170                 175     


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
            180                 185                 190         


Gly Glu Ile Asn Phe Gly Gly Gly Gly Ser Asp His Tyr Leu Asp Ile 
        195                 200                 205             


Arg Leu Arg Pro Asp Pro Glu Phe Pro Pro Ala Gln Leu Met Ser Val 
    210                 215                 220                 


Leu Phe Gly Lys Leu His Gln Ala Leu Val Ala Gln Gly Gly Asp Arg 
225                 230                 235                 240 


Ile Gly Val Ser Phe Pro Asp Leu Asp Glu Ser Arg Ser Arg Leu Gly 
                245                 250                 255     


Glu Arg Leu Arg Ile His Ala Ser Ala Asp Asp Leu Arg Ala Leu Leu 
            260                 265                 270         


Ala Arg Pro Trp Leu Glu Gly Leu Arg Asp His Leu Gln Phe Gly Glu 
        275                 280                 285             


Pro Ala Val Val Pro His Pro Thr Pro Tyr Arg Gln Val Ser Arg Val 
    290                 295                 300                 


Gln Ala Lys Ser Asn Pro Glu Arg Leu Arg Arg Arg Leu Met Arg Arg 
305                 310                 315                 320 


His Asp Leu Ser Glu Glu Glu Ala Arg Lys Arg Ile Pro Asp Thr Val 
                325                 330                 335     


Ala Arg Ala Leu Asp Leu Pro Phe Val Thr Leu Arg Ser Gln Ser Thr 
            340                 345                 350         


Gly Gln His Phe Arg Leu Phe Ile Arg His Gly Pro Leu Gln Val Thr 
        355                 360                 365             


Ala Glu Glu Gly Gly Phe Thr Cys Tyr Gly Leu Ser Lys Gly Gly Phe 
    370                 375                 380                 


Val Pro Trp Phe 
385             


<210> 42
<211> 79
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide

<400> 42
ggaaccauuc aaaacagcau agcaaguuaa aauaaggcua guccguuauc aacuugaaaa       60

aguggcaccg agucggugc                                                    79


<210> 43
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 

<400> 43
caaaacagca uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc       60

gagucggugc                                                              70


<210> 44
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 

<400> 44
uagcaaguua aaauaaggcu aguccguuau caacuugaaa aagug                       45


<210> 45
<211> 32
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 

<400> 45
uagcaaguua aaauaaggcu aguccguuau ca                                     32


<210> 46
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 

<400> 46
uagcaaguua aaauaaggcu aguccg                                            26


<210> 47
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 47
Gly Gly Gly Ser 
1               


<210> 48
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 48
Gly Gly Gly Gly Ser 
1               5   


<210> 49
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 49
ggtgagtgag tgtgtgcgtg tgg                                               23


<210> 50
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 50
gggcgatgcc acctacgg                                                     18


<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 51
gagggcgatg ccacctacgg                                                   20


<210> 52
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 52
gcgagggcga tgccacctac gg                                                22


<210> 53
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 53
ggcgagggcg atgccaccta cgg                                               23


<210> 54
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 54
gggcgagggc gatgccacct acgg                                              24


<210> 55
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 55
gagggcgagg gcgatgccac ctacgg                                            26


<210> 56
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 56
gcgcgggcga gggcgatgcc acctacgg                                          28


<210> 57
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 57
gcacgggcag cttgccggtg g                                                 21


<210> 58
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 58
gggcacgggc agcttgccgg tgg                                               23


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 59
gccgttcttc tgcttgtcgg                                                   20


<210> 60
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 60
gatgccgttc ttctgcttgt cgg                                               23


<210> 61
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 61
gtgcagatga acttcaggg                                                    19


<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 62
ggtgcagatg aacttcaggg                                                   20


<210> 63
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 63
ggtggtgcag atgaacttca ggg                                               23


<210> 64
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 64
gaggagctgt tcaccgggg                                                    19


<210> 65
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 65
gcgaggagct gttcaccggg g                                                 21


<210> 66
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 66
gggcgaggag ctgttcaccg ggg                                               23


<210> 67
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 67
gtggggggag tttgctcctg g                                                 21


<210> 68
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 68
gggtgggggg agtttgctcc tgg                                               23


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 69
gagtgagtgt gtgcgtgtgg                                                   20


<210> 70
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 70
ggtgagtgag tgtgtgcgtg tgg                                               23


<210> 71
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 71
gtccgagcag aagaagaagg g                                                 21


<210> 72
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 72
gagtccgagc agaagaagaa ggg                                               23


<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 73
gatgtagtgt ttccacaggg                                                   20


<210> 74
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 74
gcagatgtag tgtttccaca ggg                                               23


<210> 75
<211> 67
<212> DNA
<213> Homo sapiens

<400> 75
gaagctggag gaggaagggc ctgagtccga gcagaagaag aagggctccc atcacatcaa       60

ccggtgg                                                                 67


<210> 76
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
gaagctggag gagga                                                        15


<210> 77
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
tcaaccggtg g                                                            11


<210> 78
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
gaagctggag gaggaagg                                                     18


<210> 79
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
gggctcccat cacatcaacc ggtgg                                             25


<210> 80
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
gaagctggag gaggaagggc ctga                                              24


<210> 81
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
gaagctggag gagg                                                         14


<210> 82
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
gaagctggag gaggaagggc ccatcacatc aaccggtgg                              39


<210> 83
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
gaagctggag gaggaagggc tcgcacacat caaccggtgg                             40


<210> 84
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 84
gaagctggag gaggaagggc cttccatcac atcaaccggt gg                          42


<210> 85
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
gaagctggag gaggaagggc ctgagtccca tcacatcaac cggtgg                      46


<210> 86
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
gaagctggag gaggaagggc ctgagtccga gtcccatcac atcaaccggt gg               52


<210> 87
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
gaagctggag gaggaagggc ctgagtccga gcagaagtcc catcacatca accggtgg         58


<210> 88
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
gaagctggag gaggaagggc ctgagtcctg ccgtttgtag ccatcacatc aaccggtgg        59


<210> 89
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
gaagctggag gaggaagggc ctgagtccga gcagaagagc tcccatcaca tcaaccggtg       60

g                                                                       61


<210> 90
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
gaagctggag gaggaagggc ctgagtccga gcagaagaac tcccatcaca tcaaccggtg       60

g                                                                       61


<210> 91
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
gaagctggag gaggaagggc ctgagtccga gcagaagaag ggctcccatc acatcaaccg       60

gtgg                                                                    64


<210> 92
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 92
gaagctggag gaggaagggc ctgagtccga gcagaagaaa gggctcccat cacatcaacc       60

ggtgg                                                                   65


<210> 93
<211> 67
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 93
gaagctggag gaggaagggc ctgagtccga gcagaagaac agaagggctc ccatcacatc       60

aaccggt                                                                 67


<210> 94
<211> 67
<212> DNA
<213> Homo sapiens

<400> 94
gaagctggag gaggaagggc ctgagtccga gcagaagaag aagggctccc atcacatcaa       60

ccggtgg                                                                 67


<210> 95
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 95
gaagctggag gaggaagggc ctgagtccga g                                      31


<210> 96
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
gaagctggag g                                                            11


<210> 97
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 97
gaagctggag g                                                            11


<210> 98
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
gaagctggag gaggaagggc ctgagtgg                                          28


<210> 99
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 99
gaagctggag gaggaagggc tcccatcaca tcaaccggtg g                           41


<210> 100
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
gaagctggag gaggaagggc ctgagtccat cacatcaacc ggtgg                       45


<210> 101
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
gaagctggag gaggaagggc ctgagtccca tcacatcaac cggtgg                      46


<210> 102
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
gaagctggag gaggaagggc ctgagtccga gcatcacatc aaccggtgg                   49


<210> 103
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 103
gaagctggag gaggaagggc ctgagtccga gctcccatca catcaaccgg tgg              53


<210> 104
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
gaagctggag gaggaagggc ctgagtccga gcagaagggc tcccatcaca tcaaccggtg       60

g                                                                       61


<210> 105
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
gaagctggag gaggaagggc ctgagtccga gcagaagaag ggctcccatc acatcaaccg       60

gtgg                                                                    64


<210> 106
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
gaagctggag gaggaagggc ctgagtccga gcagaaagaa gggctcccat cacatcaacc       60

ggtgg                                                                   65


<210> 107
<211> 67
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
gaagctggag gaggaagggc ctgagtccga gcagaagaac agaagggctc ccatcacatc       60

aaccggt                                                                 67



