                         SEQUENCE LISTING

<110>  Bayer Healthcare LLC
	WANG, Zhuozhi
       MURPHY, John
       HERMISTON, Terry
       ZHU, Ying
 
<120>  PRO-DRUG ANTIBODIES AGAINST TISSUE FACTOR PATHWAY INHIBITOR

<130>  BAYR.P0004WO

<140>	unknown
<141>	2014-03-14

<150>  61/794,024
<151>  2013-03-15

<160>  256   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  1

Ala His Pro Arg Ile Ile Ser Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  2

Ala Arg Thr Arg Ala Arg Arg Pro 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  3

Ala Ser Ala Arg Thr Thr Gly Ser 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  4

Ala Thr Pro Arg Gly Ala Ala Pro 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  5

Ala Val Val Arg Thr Pro Pro Lys 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  6

Glu Arg Thr Arg Ser Phe Gln Leu 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  7

Phe Gly Leu Arg Phe Tyr Ala Tyr 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  8

Phe Asn Pro Arg Thr Phe Gly Ser 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  9

Phe Arg Pro Lys His Thr Arg Ile 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  10

Phe Ser Ala Arg Gly His Arg Pro 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  11

Gly Asp Ile Arg Gly Pro Arg Ile 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  12

Gly Gly Val Arg Gly Pro Arg Val 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  13

Gly Ser Phe Arg Ala Gly Leu Phe 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  14

His Lys Gly Arg Ser Ala Leu Val 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  15

Ile Ala Gly Arg Ser Leu Asn Pro 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  16

Ile Asp Gly Arg Ile Val Glu Gly 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  17

Ile Glu Pro Arg Ser Phe Ser Gln 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  18

Ile Lys Pro Arg Ile Val Gly Gly 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  19

Ile Gln Ile Arg Ser Val Ala Lys 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  20

Ile Gln Ile Arg Ser Val Ala Lys 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  21

Lys Asn Val Lys Ser Lys Ile Gly 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  22

Lys Pro Lys Asp Ser Ser Val Asp 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  23

Leu Asp Pro Arg Ser Phe Leu Leu 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  24

Leu Gly Ile Arg Ser Phe Arg Asn 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  25

Leu Pro Ile Lys Thr Phe Arg Gly 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  26

Leu Arg Pro Arg Phe Lys Ile Ile 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  27

Leu Arg Pro Arg Ile Ile Gly Gly 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  28

Leu Ser Pro Arg Gly Val His Ile 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  29

Leu Ser Pro Arg Thr Phe His Pro 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  30

Met Thr Pro Arg Ser Glu Gly Ser 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  31

Met Thr Pro Arg Ser Gly Gly Ser 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  32

Met Thr Pro Arg Ser Arg Gly Ser 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  33

Met Val Pro Arg Ala Val Tyr Leu 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  34

Asn Val Pro Arg Ile Leu Ser Pro 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  35

Pro Ala Pro Arg Gly Tyr Pro Gly 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  36

Pro Asp Leu Arg Ser Cys Val Asn 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  37

Pro Gly Pro Arg Gly Pro Pro Pro 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  38

Pro Gly Ser Arg Ser Arg Thr Pro 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  39

Pro Gln Gly Arg Ile Val Gly Gly 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  40

Pro Gln Gly Arg Thr Thr Ala His 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  41

Pro Arg Ser Phe Leu Leu Arg Asn 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  42

Gln Ser Pro Arg Ser Phe Gln Lys 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  43

Gln Ser Pro Arg Ser Phe Gln Lys 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  44

Gln Tyr Leu Arg Val Pro Leu Val 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  45

Ser Glu Phe Arg Cys Leu Thr Pro 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  46

Ser Ile Gly Arg Ala Ser Leu His 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  47

Ser Lys Gly Arg Ser Leu Ile Gly 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  48

Ser Arg Leu Arg Ala Tyr Leu Leu 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  49

Thr Cys Leu Arg Ser Thr Lys Phe 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  50

Val Cys Leu Arg Ser Phe Gln Thr 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  51

Val Asp Pro Arg Leu Ile Asp Gly 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  52

Val Glu Val Lys Ser Glu Lys Leu 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  53

Val Ile Pro Lys Arg Ile Ser Pro 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  54

Val Ile Pro Arg Ser Gly Gly Ser 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  55

Val Asn Pro Arg Gly Ile Val Thr 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  56

Val Gln Pro Arg Ala Gln Lys Ile 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  57

Val Ser Pro Arg Ala Ser Ala Ser 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  58

Val Val Pro Arg Gly Val Asn Leu 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  59

Trp Tyr Leu Arg Ser Asn Asn Gly 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  60

Trp Tyr Leu Arg Ser Asn Thr Gly 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  61

Ala Phe Trp Lys Thr Asp Ala Ser 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  62

Ile Glu Gly Arg Thr Ala Thr Ser 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  63

Thr Ala Ala Arg Gln Ser Thr Asn 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  64

Ile Asp Gly Arg Ile Val Glu Gly 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  65

Phe Asn Pro Arg Thr Phe Gly Ser 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  66

Arg Val Pro Lys Ser Phe Pro Phe 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  67

Pro Gln Leu Arg Met Lys Asn Asn 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  68

Ser Ser Trp Arg Leu Thr Ser Ser 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  69

Leu Gly Ile Arg Ser Phe Arg Asn 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  70

Ala Met Ser Arg Met Ser Leu Ser 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  71

Ala Asn Asn Arg Asp Asn Thr Tyr 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  72

Ala Asn Val Arg Arg Lys Arg Tyr 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  73

Ala Arg Gly Arg Ala Phe Pro Gln 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  74

Ala Thr Leu Lys Ser Arg Lys Met 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  75

Ala Thr Gln Lys Lys Val Glu Arg 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  76

Ala Thr Trp Lys Thr Arg Trp Tyr 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  77

Asp Val Gly Glu Tyr Asn Val Phe 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  78

Glu Ala Arg Gly Ser Val Ile Leu 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  79

Glu Ala Tyr Arg Arg Phe Tyr Gly 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  80

Glu Asp Asn Arg Asp Ser Ser Met 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  81

Glu Thr Leu Lys Val Ile Asp Glu 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  82

Phe Arg Ala Arg Ala Tyr Gly Phe 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  83

Gly Glu Ala Arg Gly Ser Val Ile 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  84

Gly Gly Tyr Arg Ala Arg Pro Ala 
1               5               


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  85

Gly Ile Leu Lys Glu Asn Ala Ala 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  86

Gly Pro Lys Arg Gly Thr Glu Pro 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  87

Ile Ile Arg Arg Ser Ile Gln Ile 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  88

Ile Thr Phe Arg Met Asn Val Ala 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  89

Lys His Ser Lys Arg His Ile His 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  90

Lys Lys Asp Arg Ala Arg Gln Glu 
1               5               


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  91

Lys Lys Pro Arg Cys Gly Val Pro 
1               5               


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  92

Lys Gln Val Lys Asp Asn Glu Asn 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  93

Leu Asp Pro Arg Ser Phe Leu Leu 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  94

Leu Pro Pro Lys Ser Gln Pro Pro 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  95

Leu Ser Phe Arg Ala Arg Ala Tyr 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  96

Met Ser Met Arg Val Arg Arg His 
1               5               


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  97

Asn Ser Gly Arg Ala Val Thr Tyr 
1               5               


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  98

Pro Ala Pro Arg Gly Tyr Pro Gly 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  99

Pro Glu Ala Lys Ala Ser Cys Tyr 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  100

Pro Glu Ser Lys Ala Thr Asn Ala 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  101

Pro Gly Pro Lys Arg Gly Thr Glu 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  102

Pro Lys Ala Lys Ser His Ala Pro 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  103

Pro Leu Asp Lys Lys Arg Glu Glu 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  104

Pro Leu Gln Lys Gln Leu Pro Ala 
1               5               


<210>  105
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  105

Pro Gln Phe Arg Ile Lys Gly Gly 
1               5               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  106

Pro Gln Leu Arg Leu Pro His Thr 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  107

Pro Gln Leu Arg Arg Gly Trp Arg 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  108

Pro Gln Ser Arg Ser Val Pro Pro 
1               5               


<210>  109
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  109

Pro Arg Phe Lys Ile Ile Gly Gly 
1               5               


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  110

Pro Tyr Leu Lys Val Phe Asn Pro 
1               5               


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  111

Gln Lys Ser Arg Asn Gly Leu Arg 
1               5               


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  112

Gln Leu Ile Lys Ala Ile Gln Leu 
1               5               


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  113

Gln Arg Tyr Lys Val Asp Tyr Glu 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  114

Arg Ala Gln Arg Ser Ala Gly Ala 
1               5               


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  115

Arg Gly Pro Arg Val Val Glu Arg 
1               5               


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  116

Arg Pro Ala Lys Ala Ala Ala Thr 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  117

Arg Arg Lys Arg Tyr Ala Ile Gln 
1               5               


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  118

Arg Ser Ser Lys Gly Arg Ser Leu 
1               5               


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  119

Arg Ser Thr Arg Phe Ala Ala Thr 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  120

Ser Cys Asp Lys Thr His Thr Cys 
1               5               


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  121

Ser Ile Asn Lys Ser Ser Pro Leu 
1               5               


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  122

Ser Gln Pro Pro Glu Lys Thr Glu 
1               5               


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  123

Ser Gln Arg Lys His Ser Lys Arg 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  124

Ser Ser Met Lys Leu Ser Phe Arg 
1               5               


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  125

Thr Glu Pro Lys Val Lys Leu Pro 
1               5               


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  126

Thr Glu Tyr Arg Leu Val Ser Ile 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  127

Thr His Glu Lys Gly Arg Gln Ser 
1               5               


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  128

Thr Tyr Ser Lys Ala Ser Thr Pro 
1               5               


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  129

Thr Tyr Ser Arg Ser Arg Tyr Leu 
1               5               


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  130

Val Ser Asn Lys Val Ser Met Ser 
1               5               


<210>  131
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab-1 light chain

<400>  131

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe 
        35                  40                  45              


Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Leu 
            100                 105                 110         


Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Gly Gln Pro Lys Ala Ala 
        115                 120                 125             


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
    130                 135                 140                 


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
145                 150                 155                 160 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
                165                 170                 175     


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
            180                 185                 190         


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
        195                 200                 205             


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
    210                 215                 220                 


Thr Glu Cys Ser 
225             


<210>  132
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site and linker

<400>  132

Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  133
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab-1 heavy chain

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
        195                 200                 205             


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Asp Tyr Lys Asp Asp Asp Asp Lys His 
225                 230                 235                 240 


His His His His His 
                245 


<210>  134
<211>  1590
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Fab-1

<400>  134
ggtctcacat gaaaaaaacc gctatcgcta tcgccgtcgc actggctggc ttcgcaaccg       60

tggcacaggc atcctatgaa ctgacccaac cgccgagtgt ctccgtgtca ccgggtcaga      120

cggcacgtat tacctgcagc ggtgataacc tgccgaaata ttacgcgcat tggtatcagc      180

aaaaaccggg ccaagccccg gtggttgtca tcttttatga cgttaatcgt ccgtccggta      240

tcccggaacg cttctcgggc agcaactctg gtaatacggc aaccctgacg atcagcggca      300

cccaggcaat ggatgaagct gactattact gtcaagcatg gtggagctct acgccggtgt      360

ttggcggtgg cacgaaactg accgtgctgg gtggcggtgg ctctctggtt ccgcgtggct      420

ccggtggcgg tggctcaggc cagccgaaag cagcaccgag tgttaccctg tttccgccga      480

gttccgaaga actgcaagca aacaaagcta ccctggtgtg cctgattagc gatttctatc      540

cgggcgcagt tacggtcgcg tggaaagccg actcatcgcc ggtgaaagct ggtgttgaaa      600

ccacgacccc gtcaaaacag tcgaacaata aatatgcagc tagctcttac ctgtctctga      660

ccccggaaca gtggaaaagt catcgcagtt actcctgtca agttacgcac gaaggctcca      720

cggtcgaaaa aaccgtggca ccgacggaat gctcatgata agcatgcgta ggagaaaata      780

aaatgaaaca gtctaccatc gcactggcac tgctgccgct gctgtttacg ccggtgacca      840

aagcagaagt tcagctggtc gaaagtggtg gcggtctggt tcaaccgggc ggttcactgc      900

gtctgtcgtg cgcagcaagc ggttttacct tcagttccta tggtatggat tgggtccgtc      960

aggcaccggg taaaggtctg gaatgggtgt catcgattcg tggcagccgc ggttctacct     1020

attacgccga ttcagttaaa ggccgtttta ccatctctcg cgacaacagt aaaaatacgc     1080

tgtatctgca gatgaacagc ctgcgcgcgg aagataccgc cgtgtattac tgtgcccgtc     1140

tgtatcgcta ctggttcgac tactggggcc agggtacgct ggtgaccgtt agctctggcg     1200

gtggcggttc gctggtcccg cgtggcagcg gcggtggcgg ttcagcgagc accaaaggtc     1260

cgagcgtgtt tccgctggca ccgtgcagcc gctctaccag tgaatccacg gcagctctgg     1320

gttgtctggt gaaagattat tttccggaac cggtcaccgt gagttggaac tccggcgcac     1380

tgacctcggg tgttcatacg ttcccggctg tcctgcagag ttccggcctg tatagcctgt     1440

catcggtggt taccgttccg agctctaatt tcggcaccca aacgtacacc tgcaacgtcg     1500

atcacaaacc gtctaatacc aaagttgaca aaacggttga ttacaaagac gacgacgaca     1560

aacaccacca ccaccaccat tgataagctt                                      1590


<210>  135
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab-2 light chain

<400>  135

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe 
        35                  40                  45              


Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Leu Val Pro Arg Gly Ser 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  136
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab-2 Heavy Chain

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Leu Val Pro Arg Gly Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Asp Tyr Lys 
    210                 215                 220                 


Asp Asp Asp Asp Lys His His His His His His 
225                 230                 235 


<210>  137
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  137

Leu Val Pro Arg Gly Ser 
1               5       


<210>  138
<211>  1530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab-2 coding sequence

<400>  138
ggtctcacat gaaaaaaacg gctatcgcaa tcgctgtggc actggcaggc ttcgcaacgg       60

tcgcgcaggc atcctatgaa ctgacgcaac cgccgagtgt ctccgtgtca ccgggtcaga      120

cggcacgtat tacctgctct ggtgataacc tgccgaaata ttacgcgcat tggtatcagc      180

aaaaaccggg ccaagccccg gtggttgtca tcttttatga cgttaatcgt ccgtcgggta      240

tcccggaacg cttctcgggc agcaactctg gtaatacggc caccctgacg atctcaggca      300

cccaggcaat ggatgaagct gactattact gccaagcatg gtggagctct acgccggtgt      360

ttggcggtgg cacgaaactg accgttctgc tggtcccgcg tggctccggt cagccgaaag      420

cagccccgtc agttaccctg tttccgccga gttccgaaga actgcaagca aacaaagcta      480

ccctggtgtg tctgattagc gatttctatc cgggcgcagt tacggtcgcg tggaaagccg      540

actcatcgcc ggtcaaagct ggtgtggaaa ccaccacccc gtcaaaacag tcgaacaata      600

aatatgcagc tagctcttac ctgtcgctga ccccggaaca gtggaaaagc catcgcagtt      660

actcctgcca agttacgcac gaaggctcta cggttgaaaa aaccgtcgca ccgacggaat      720

gcagttgata agcatgcgta ggagaaaata aaatgaaaca gagcaccatc gcactggcac      780

tgctgccgct gctgtttacg ccggtcacca aagcagaagt gcagctggtt gaatctggtg      840

gcggtctggt gcaaccgggc ggttcactgc gtctgtcgtg tgcggccagc ggctttacct      900

tcagttccta tggtatggat tgggtccgtc aggcaccggg taaaggtctg gaatgggtgt      960

catcgattcg tggcagccgc ggttctacct attacgccga ttccgttaaa ggccgtttca     1020

ccatctctcg cgacaacagt aaaaatacgc tgtatctgca gatgaacagt ctgcgcgcgg     1080

aagataccgc cgtgtattac tgcgcccgtc tgtatcgcta ctggtttgac tactggggcc     1140

agggtacgct ggtgaccgtt agctctctgg ttccgcgtgg ctcagcgagc accaaaggtc     1200

cgagtgtctt cccgctggca ccgtgcagcc gctctaccag tgaatccacg gcagctctgg     1260

gttgtctggt gaaagattat tttccggaac cggtcaccgt gagttggaac tccggcgcac     1320

tgacctccgg tgtgcatacg ttcccggctg ttctgcagag ttccggcctg tattcactgt     1380

catcggtggt taccgtgccg agctctaatt ttggcaccca aacgtacacc tgtaacgttg     1440

atcacaaacc gagcaatacc aaagttgaca aaaccgttga ctacaaagac gacgacgaca     1500

aacaccacca ccaccaccac tgataagctt                                      1530


<210>  139
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2-linker 1, Light chain amino acid sequence

<400>  139

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe 
        35                  40                  45              


Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Leu 
            100                 105                 110         


Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Gly Gln Pro Lys Ala Ala 
        115                 120                 125             


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
    130                 135                 140                 


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
145                 150                 155                 160 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
                165                 170                 175     


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
            180                 185                 190         


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
        195                 200                 205             


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
    210                 215                 220                 


Thr Glu Cys Ser 
225             


<210>  140
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2-linker 1, heavy chain amino acid sequence

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
        195                 200                 205             


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455             


<210>  141
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG2-linker 1, Light chain DNA sequence

<400>  141
tcctacgagc tgacccagcc cccttccgtg tccgtgtctc ctggccagac cgcccggatc       60

acctgttccg gcgacaacct gcccaagtac tacgcccact ggtatcagca gaagcccggc      120

caggcccccg tggtggtcat cttctacgac gtgaaccggc cctccggcat ccccgagaga      180

ttctccggct ccaactccgg caacaccgcc accctgacca tctccggcac ccaggccatg      240

gacgaggccg actactactg ccaggcttgg tggtcctcca cccccgtgtt tggcggcgga      300

acaaagttaa ccgtgctggg cggtggagga tcactggttc cgcgtggctc tggcggtgga      360

ggatcaggcc agcccaaggc cgctccttcc gtgaccctgt tccccccatc ctccgaggaa      420

ctgcaggcca acaaggccac cctggtctgc ctgatctccg acttctaccc tggcgccgtg      480

accgtggcct ggaaggccga cagctctcct gtgaaggccg gcgtggaaac caccaccccc      540

tccaagcagt ccaacaacaa atacgccgcc tcctcctacc tgtccctgac ccccgagcag      600

tggaagtccc accggtccta cagctgccag gtcacacacg agggctccac cgtggaaaag      660

acagtggccc ccaccgagtg ctct                                             684


<210>  142
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG2-linker 1, Heavy chain DNA sequence

<400>  142
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc agctacggca tggactgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtgtcctcc atccggggct ctcggggctc cacctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc cagactgtac      300

cggtattggt tcgactactg gggccagggc accctggtca ccgtcagctc aggcggtgga      360

ggatcactgg ttccgcgtgg ctctggcggt ggaggatcag cttccaccaa gggcccctcc      420

gtgttccctc tggccccttg ctcccggtcc acctctgagt ctaccgccgc tctgggctgc      480

ctggtgaaag actacttccc cgagcccgtg accgtgtcct ggaactctgg cgccctgacc      540

tccggcgtgc acacctttcc agccgtgctg cagtcctccg gcctgtactc cctgtcctcc      600

gtggtgacag tgccctcctc caacttcggc acccagacct acacctgtaa cgtggaccac      660

aagccctcca acaccaaggt ggacaagacc gtggaacgga agtgctgcgt ggaatgccca      720

ccctgtcctg ctccacctgt ggctggcccc agcgtgttcc tgttcccccc aaagcccaag      780

gacaccctga tgatctcccg gacccccgaa gtgacctgcg tggtggtgga cgtgtcccac      840

gaggaccccg aggtgcagtt caattggtac gtggacggcg tggaagtgca caacgccaag      900

accaagccca gagaggaaca gttcaactcc accttccggg tggtgtccgt gctgaccgtg      960

gtgcatcagg actggctgaa cggcaaagag tacaagtgca aggtctccaa caagggcctg     1020

cctgccccca tcgaaaagac catcagcaag accaagggcc agccccgcga gccccaggtg     1080

tacacactgc cccccagccg ggaagagatg accaagaacc aggtgtccct gacctgtctg     1140

gtgaaaggct tctacccctc cgacattgcc gtggaatggg agtccaacgg acagcctgag     1200

aacaactaca agaccacccc ccccatgctg gactccgacg gctcattctt cctgtactcc     1260

aagctgacag tggacaagtc ccggtggcag cagggcaacg tgttctcctg ctccgtgatg     1320

cacgaggccc tgcacaacca ctacacccag aagtccctgt ccctgagccc cggc           1374


<210>  143
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2-linker 2, Light chain amino acid sequence

<400>  143

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe 
        35                  40                  45              


Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Leu Val Pro Arg Gly Ser 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  144
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2-linker 2, heavy chain amino acid sequence

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Leu Val Pro Arg Gly Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
    210                 215                 220                 


Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  145
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG2-linker 2, Light chain DNA sequence

<400>  145
tcctacgagc tgacccagcc cccttccgtg tccgtgtctc ctggccagac cgcccggatc       60

acctgttccg gcgacaacct gcccaagtac tacgcccact ggtatcagca gaagcccggc      120

caggcccccg tggtggtcat cttctacgac gtgaaccggc cctccggcat ccccgagaga      180

ttctccggct ccaactccgg caacaccgcc accctgacca tctccggcac ccaggccatg      240

gacgaggccg actactactg ccaggcttgg tggtcctcca cccccgtgtt tggcggcgga      300

acaaagttaa ccgtgctgct ggttccgcgt ggctctggcc agcccaaggc cgctccttcc      360

gtgaccctgt tccccccatc ctccgaggaa ctgcaggcca acaaggccac cctggtctgc      420

ctgatctccg acttctaccc tggcgccgtg accgtggcct ggaaggccga cagctctcct      480

gtgaaggccg gcgtggaaac caccaccccc tccaagcagt ccaacaacaa atacgccgcc      540

tcctcctacc tgtccctgac ccccgagcag tggaagtccc accggtccta cagctgccag      600

gtcacacacg agggctccac cgtggaaaag acagtggccc ccaccgagtg ctct            654


<210>  146
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG2-linker 2, Heavy chain DNA sequence

<400>  146
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc agctacggca tggactgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtgtcctcc atccggggct ctcggggctc cacctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc cagactgtac      300

cggtattggt tcgactactg gggccagggc accctggtca ccgtcagctc actggttccg      360

cgtggctctg cttccaccaa gggcccctcc gtgttccctc tggccccttg ctcccggtcc      420

acctctgagt ctaccgccgc tctgggctgc ctggtgaaag actacttccc cgagcccgtg      480

accgtgtcct ggaactctgg cgccctgacc tccggcgtgc acacctttcc agccgtgctg      540

cagtcctccg gcctgtactc cctgtcctcc gtggtgacag tgccctcctc caacttcggc      600

acccagacct acacctgtaa cgtggaccac aagccctcca acaccaaggt ggacaagacc      660

gtggaacgga agtgctgcgt ggaatgccca ccctgtcctg ctccacctgt ggctggcccc      720

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatctcccg gacccccgaa      780

gtgacctgcg tggtggtgga cgtgtcccac gaggaccccg aggtgcagtt caattggtac      840

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaactcc      900

accttccggg tggtgtccgt gctgaccgtg gtgcatcagg actggctgaa cggcaaagag      960

tacaagtgca aggtctccaa caagggcctg cctgccccca tcgaaaagac catcagcaag     1020

accaagggcc agccccgcga gccccaggtg tacacactgc cccccagccg ggaagagatg     1080

accaagaacc aggtgtccct gacctgtctg gtgaaaggct tctacccctc cgacattgcc     1140

gtggaatggg agtccaacgg acagcctgag aacaactaca agaccacccc ccccatgctg     1200

gactccgacg gctcattctt cctgtactcc aagctgacag tggacaagtc ccggtggcag     1260

cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag     1320

aagtccctgt ccctgagccc cggc                                            1344


<210>  147
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavage site


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  Xaa = hydrophobic amino acid

<220>
<221>  VARIANT
<222>  (5)..(6)
<223>  Xaa = nonacidic amino acid

<400>  147

Xaa Xaa Pro Arg Xaa Xaa 
1               5       


<210>  148
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Factor Xa cleavage site


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa = Glu or Asp

<400>  148

Ile Xaa Gly Arg 
1               


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  149

Gly Gly Gly Gly Ser 
1               5   


<210>  150
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 95-152 of SEQ ID NO:133

<400>  150

Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly 
1               5                   10                  15      


Thr Leu Val Thr Val Ser Ser Ala Ser Gly Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Pro Arg Gly Ser Gly Gly Gly Gly Ser Thr Lys Gly Pro Ser Val Phe 
        35                  40                  45              


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    50                  55              


<210>  151
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  151

Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      


<210>  152
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  152

Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      


Val 
    


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  153

Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   


<210>  154
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  154

Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   10  


<210>  155
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  155

Ser Ala Lys Thr Thr Pro 
1               5       


<210>  156
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  156

Arg Ala Asp Ala Ala Pro 
1               5       


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  157

Arg Ala Asp Ala Ala Pro Thr Val Ser 
1               5                   


<210>  158
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  158

Arg Ala Asp Ala Ala Ala Ala Gly Gly Pro Gly Ser 
1               5                   10          


<210>  159
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  159

Arg Ala Asp Ala Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25          


<210>  160
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  160

Ser Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
1               5                   10                  15      


Arg Val 
        


<210>  161
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  161

Ala Asp Ala Ala Pro 
1               5   


<210>  162
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  162

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
1               5                   10          


<210>  163
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  163

Thr Val Ala Ala Pro 
1               5   


<210>  164
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  164

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10          


<210>  165
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  165

Gln Pro Lys Ala Ala Pro 
1               5       


<210>  166
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  166

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
1               5                   10              


<210>  167
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  167

Ala Lys Thr Thr Pro Pro 
1               5       


<210>  168
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  168

Ala Lys Thr Thr Pro Pro Ser Val Thr Pro Leu Ala Pro 
1               5                   10              


<210>  169
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  169

Ala Lys Thr Thr Ala Pro 
1               5       


<210>  170
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  170

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
1               5                   10              


<210>  171
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  171

Ala Ser Thr Lys Gly Pro 
1               5       


<210>  172
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  172

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              


<210>  173
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  173

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  174
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  174

Gly Glu Asn Lys Val Glu Tyr Ala Pro Ala Leu Met Ala Leu Ser 
1               5                   10                  15  


<210>  175
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  175

Gly Pro Ala Lys Glu Leu Thr Pro Leu Lys Glu Ala Lys Val Ser 
1               5                   10                  15  


<210>  176
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  176

Gly His Glu Ala Ala Ala Val Met Gln Val Gln Tyr Pro Ala Ser 
1               5                   10                  15  


<210>  177
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
            180                 185                 190         


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440         


<210>  178
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  178

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe 
        35                  40                  45              


Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  179
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease-cleavable anti-TFPI scFv antibody

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser 
    130                 135                 140                 


Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu 
145                 150                 155                 160 


Pro Lys Tyr Tyr Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Val Val Val Ile Phe Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu 
            180                 185                 190         


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
        195                 200                 205             


Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp 
    210                 215                 220                 


Ser Ser Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 


<210>  180
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  protease-cleavable anti-TFPI scFv antibody coding sequence

<400>  180
gaagttcagc tggtcgaaag tggtggcggt ctggttcaac cgggcggttc actgcgtctg       60

tcgtgcgcag caagcggttt taccttcagt tcctatggta tggattgggt ccgtcaggca      120

ccgggtaaag gtctggaatg ggtgtcatcg attcgtggca gccgcggttc tacctattac      180

gccgattcag ttaaaggccg ttttaccatc tctcgcgaca acagtaaaaa tacgctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgccgtgt attactgtgc ccgtctgtat      300

cgctactggt tcgactactg gggccagggt acgctggtga ccgttagctc tggtggcggt      360

ggctctctgg ttccgcgtgg ctccggtggc ggtggctcat cctatgaact gacccaaccg      420

ccgagtgtct ccgtgtcacc gggtcagacg gcacgtatta cctgcagcgg tgataacctg      480

ccgaaatatt acgcgcattg gtatcagcaa aaaccgggcc aagccccggt ggttgtcatc      540

ttttatgacg ttaatcgtcc gtccggtatc ccggaacgct tctcgggcag caactctggt      600

aatacggcaa ccctgacgat cagcggcacc caggcaatgg atgaagctga ctattactgt      660

caagcatggt ggagctctac gccggtgttt ggcggtggca cgaaactgac cgtgctg         717


<210>  181
<211>  569
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  181

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Ser Ser Pro Ala Ser Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Ser Glu Gly Arg Thr Ala Thr Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
145                 150                 155                 160 


Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                245                 250                 255     


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
            260                 265                 270         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        275                 280                 285             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    290                 295                 300                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
305                 310                 315                 320 


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
                325                 330                 335     


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
            340                 345                 350         


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
        355                 360                 365             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    370                 375                 380                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
385                 390                 395                 400 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                405                 410                 415     


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
            420                 425                 430         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        435                 440                 445             


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
    450                 455                 460                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
465                 470                 475                 480 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                485                 490                 495     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            500                 505                 510         


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
        515                 520                 525             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    530                 535                 540                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
545                 550                 555                 560 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 


<210>  182
<211>  565
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  182

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Ser Ser Pro Ala Ser Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Ser Glu Gly Arg Thr Ala Thr Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly 
                165                 170                 175     


Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg 
    210                 215                 220                 


Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
                245                 250                 255     


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            260                 265                 270         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        275                 280                 285             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    290                 295                 300                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
305                 310                 315                 320 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                325                 330                 335     


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            340                 345                 350         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        355                 360                 365             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    370                 375                 380                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
385                 390                 395                 400 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                405                 410                 415     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            420                 425                 430         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        435                 440                 445             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    450                 455                 460                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
465                 470                 475                 480 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                485                 490                 495     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            500                 505                 510         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        515                 520                 525             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    530                 535                 540                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
545                 550                 555                 560 


Ser Leu Ser Pro Gly 
                565 


<210>  183
<211>  561
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  183

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Ser Ser Pro Ala Ser Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Ser Glu Gly Arg Thr Ala Thr Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    130                 135                 140                 


Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser 
                165                 170                 175     


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            180                 185                 190         


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        195                 200                 205             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
225                 230                 235                 240 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
                245                 250                 255     


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
            260                 265                 270         


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
        275                 280                 285             


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
    290                 295                 300                 


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
305                 310                 315                 320 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
                325                 330                 335     


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
            340                 345                 350         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        355                 360                 365             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    370                 375                 380                 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
385                 390                 395                 400 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
                405                 410                 415     


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
            420                 425                 430         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
        435                 440                 445             


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    450                 455                 460                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
465                 470                 475                 480 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                485                 490                 495     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
            500                 505                 510         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        515                 520                 525             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    530                 535                 540                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
545                 550                 555                 560 


Gly 
    


<210>  184
<211>  566
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  184

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Ser Ser Pro Ala Ser Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Glu Gly Arg Thr Ala Thr Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg 
                165                 170                 175     


Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr 
    210                 215                 220                 


Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
                245                 250                 255     


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            260                 265                 270         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        275                 280                 285             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    290                 295                 300                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
305                 310                 315                 320 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
                325                 330                 335     


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
            340                 345                 350         


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        355                 360                 365             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    370                 375                 380                 


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
385                 390                 395                 400 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                405                 410                 415     


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
            420                 425                 430         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        435                 440                 445             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
    450                 455                 460                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
465                 470                 475                 480 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                485                 490                 495     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            500                 505                 510         


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        515                 520                 525             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    530                 535                 540                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
545                 550                 555                 560 


Leu Ser Leu Ser Pro Gly 
                565     


<210>  185
<211>  562
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  185

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Ser Ser Pro Ala Ser Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Glu Gly Arg Thr Ala Thr Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly 
                165                 170                 175     


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
225                 230                 235                 240 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
                245                 250                 255     


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            260                 265                 270         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        275                 280                 285             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
305                 310                 315                 320 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
                325                 330                 335     


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
            340                 345                 350         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        355                 360                 365             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    370                 375                 380                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
385                 390                 395                 400 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
                405                 410                 415     


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
            420                 425                 430         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
        435                 440                 445             


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
    450                 455                 460                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
465                 470                 475                 480 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                485                 490                 495     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            500                 505                 510         


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        515                 520                 525             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    530                 535                 540                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
545                 550                 555                 560 


Pro Gly 
        


<210>  186
<211>  558
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  186

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Ser Ser Pro Ala Ser Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Glu Gly Arg Thr Ala Thr Gly Gly Leu Val 
        115                 120                 125             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
    130                 135                 140                 


Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly 
145                 150                 155                 160 


Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr 
                165                 170                 175     


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
            180                 185                 190         


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        195                 200                 205             


Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
225                 230                 235                 240 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
                245                 250                 255     


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
            260                 265                 270         


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
        275                 280                 285             


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
    290                 295                 300                 


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
305                 310                 315                 320 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
                325                 330                 335     


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
            340                 345                 350         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        355                 360                 365             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    370                 375                 380                 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
385                 390                 395                 400 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
                405                 410                 415     


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            420                 425                 430         


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        435                 440                 445             


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    450                 455                 460                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
465                 470                 475                 480 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                485                 490                 495     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
            500                 505                 510         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        515                 520                 525             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    530                 535                 540                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
545                 550                 555             


<210>  187
<211>  563
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  187

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Ser Ser Pro Ala Ser Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Glu Gly Arg Thr Ala Thr Glu Val Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg 
                165                 170                 175     


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp 
    210                 215                 220                 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
225                 230                 235                 240 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
                245                 250                 255     


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            260                 265                 270         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        275                 280                 285             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    290                 295                 300                 


Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr 
305                 310                 315                 320 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 
                325                 330                 335     


Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
            340                 345                 350         


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        355                 360                 365             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    370                 375                 380                 


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
385                 390                 395                 400 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                405                 410                 415     


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
            420                 425                 430         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
        435                 440                 445             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
    450                 455                 460                 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
465                 470                 475                 480 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                485                 490                 495     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            500                 505                 510         


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        515                 520                 525             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    530                 535                 540                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
545                 550                 555                 560 


Ser Pro Gly 
            


<210>  188
<211>  559
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  188

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Ser Ser Pro Ala Ser Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Glu Gly Arg Thr Ala Thr Val Glu Ser Gly Gly Gly Leu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    130                 135                 140                 


Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr 
                165                 170                 175     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
            180                 185                 190         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
225                 230                 235                 240 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
                245                 250                 255     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            260                 265                 270         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        275                 280                 285             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    290                 295                 300                 


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
305                 310                 315                 320 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
                325                 330                 335     


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
545                 550                 555                 


<210>  189
<211>  555
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  189

Gln Val Glu Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Ser Ser Pro Ala Ser Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Glu Gly Arg Thr Ala Thr Gly Gly Leu Val Gln Pro Gly 
        115                 120                 125             


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
    130                 135                 140                 


Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
145                 150                 155                 160 


Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser 
                165                 170                 175     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
        195                 200                 205             


Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr 
    210                 215                 220                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
225                 230                 235                 240 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
                245                 250                 255     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            260                 265                 270         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        275                 280                 285             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    290                 295                 300                 


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
305                 310                 315                 320 


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
                325                 330                 335     


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
            340                 345                 350         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        355                 360                 365             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
    370                 375                 380                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
385                 390                 395                 400 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
                405                 410                 415     


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            420                 425                 430         


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
        435                 440                 445             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    450                 455                 460                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
465                 470                 475                 480 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                485                 490                 495     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
            500                 505                 510         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        515                 520                 525             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    530                 535                 540                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
545                 550                 555 


<210>  190
<211>  331
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  190

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala 
            100                 105                 110         


Ser Glu Gly Arg Thr Ala Thr Ser Tyr Glu Leu Thr Gln Pro Pro Ser 
        115                 120                 125             


Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp 
    130                 135                 140                 


Asn Leu Pro Lys Tyr Tyr Ala His Trp Tyr Gln Gln Lys Pro Gly Gln 
145                 150                 155                 160 


Ala Pro Val Val Val Ile Phe Tyr Asp Val Asn Arg Pro Ser Gly Ile 
                165                 170                 175     


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
            180                 185                 190         


Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala 
        195                 200                 205             


Trp Trp Ser Ser Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
    210                 215                 220                 


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
225                 230                 235                 240 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
                245                 250                 255     


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
            260                 265                 270         


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
        275                 280                 285             


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
    290                 295                 300                 


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
305                 310                 315                 320 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
                325                 330     


<210>  191
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  191

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala 
            100                 105                 110         


Ser Glu Gly Arg Thr Ala Thr Thr Gln Pro Pro Ser Val Ser Val Ser 
        115                 120                 125             


Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys 
    130                 135                 140                 


Tyr Tyr Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val 
145                 150                 155                 160 


Val Ile Phe Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe 
                165                 170                 175     


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr 
            180                 185                 190         


Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser 
        195                 200                 205             


Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    210                 215                 220                 


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
225                 230                 235                 240 


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
                245                 250                 255     


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
            260                 265                 270         


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
        275                 280                 285             


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
    290                 295                 300                 


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
305                 310                 315                 320 


Val Ala Pro Thr Glu Cys Ser 
                325         


<210>  192
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  192

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala 
            100                 105                 110         


Ser Glu Gly Arg Thr Ala Thr Ser Val Ser Val Ser Pro Gly Gln Thr 
        115                 120                 125             


Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala His 
    130                 135                 140                 


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe Tyr 
145                 150                 155                 160 


Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
                165                 170                 175     


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp 
            180                 185                 190         


Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val Phe 
        195                 200                 205             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
    210                 215                 220                 


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
225                 230                 235                 240 


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
                245                 250                 255     


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
            260                 265                 270         


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
        275                 280                 285             


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
    290                 295                 300                 


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
305                 310                 315                 320 


Glu Cys Ser 
            


<210>  193
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  193

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu 
            100                 105                 110         


Gly Arg Thr Ala Thr Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser 
        115                 120                 125             


Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu 
    130                 135                 140                 


Pro Lys Tyr Tyr Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
145                 150                 155                 160 


Val Val Val Ile Phe Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu 
                165                 170                 175     


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
            180                 185                 190         


Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp 
        195                 200                 205             


Ser Ser Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
    210                 215                 220                 


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
225                 230                 235                 240 


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
                245                 250                 255     


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
            260                 265                 270         


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
        275                 280                 285             


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
    290                 295                 300                 


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
305                 310                 315                 320 


Lys Thr Val Ala Pro Thr Glu Cys Ser 
                325                 


<210>  194
<211>  325
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  194

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu 
            100                 105                 110         


Gly Arg Thr Ala Thr Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly 
        115                 120                 125             


Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr 
    130                 135                 140                 


Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile 
145                 150                 155                 160 


Phe Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
                165                 170                 175     


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala 
            180                 185                 190         


Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro 
        195                 200                 205             


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
    210                 215                 220                 


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
225                 230                 235                 240 


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
                245                 250                 255     


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
            260                 265                 270         


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
        275                 280                 285             


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
    290                 295                 300                 


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
305                 310                 315                 320 


Pro Thr Glu Cys Ser 
                325 


<210>  195
<211>  321
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  195

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu 
            100                 105                 110         


Gly Arg Thr Ala Thr Ser Val Ser Val Ser Pro Gly Gln Thr Ala Arg 
        115                 120                 125             


Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala His Trp Tyr 
    130                 135                 140                 


Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe Tyr Asp Val 
145                 150                 155                 160 


Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
                165                 170                 175     


Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala 
            180                 185                 190         


Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val Phe Gly Gly 
        195                 200                 205             


Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val 
    210                 215                 220                 


Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr 
225                 230                 235                 240 


Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala 
                245                 250                 255     


Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr 
            260                 265                 270         


Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser 
        275                 280                 285             


Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val 
    290                 295                 300                 


Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys 
305                 310                 315                 320 


Ser 
    


<210>  196
<211>  690
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  196

Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asn Phe Met Leu Thr Gln Pro His 
    130                 135                 140                 


Ser Val Ser Ala Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg 
145                 150                 155                 160 


Ser Ser Gly Ser Val Ala Ser Tyr Tyr Val Gln Trp Tyr Gln Gln Arg 
                165                 170                 175     


Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu Asp Asn His Arg Pro 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Thr Ser Ser Asn 
        195                 200                 205             


Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Gln Ser Tyr Asp Ser Asn Asn Leu Val Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu Gly Glu Gly Arg Thr Ala Thr Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly 
    290                 295                 300                 


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe 
            340                 345                 350         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        355                 360                 365             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    370                 375                 380                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
385                 390                 395                 400 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                405                 410                 415     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            420                 425                 430         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        435                 440                 445             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    450                 455                 460                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
465                 470                 475                 480 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                485                 490                 495     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            500                 505                 510         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        515                 520                 525             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    530                 535                 540                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
545                 550                 555                 560 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                565                 570                 575     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            580                 585                 590         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        595                 600                 605             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    610                 615                 620                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
625                 630                 635                 640 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                645                 650                 655     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            660                 665                 670         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        675                 680                 685             


Pro Gly 
    690 


<210>  197
<211>  683
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  197

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Ile Gln Ser Pro Ser 
    130                 135                 140                 


Val Leu Ser Ala Ser Val Gly Asp Arg Val Thr Leu Asn Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Asn Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly 
                165                 170                 175     


Glu Ala Pro Lys Val Leu Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe 
    210                 215                 220                 


Gln His Tyr Thr Trp Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Glu Gly Arg Thr Ala Thr Ser Gly Gly Gly Leu Val Gln Pro Gly 
                245                 250                 255     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            260                 265                 270         


Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        275                 280                 285             


Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr 
            340                 345                 350         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        355                 360                 365             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    370                 375                 380                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
385                 390                 395                 400 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                405                 410                 415     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            420                 425                 430         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        435                 440                 445             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    450                 455                 460                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
465                 470                 475                 480 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                485                 490                 495     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            500                 505                 510         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        515                 520                 525             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    530                 535                 540                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
545                 550                 555                 560 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                565                 570                 575     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            580                 585                 590         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        595                 600                 605             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    610                 615                 620                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
625                 630                 635                 640 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                645                 650                 655     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            660                 665                 670         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680             


<210>  198
<211>  212
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  198

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe 
        35                  40                  45              


Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  199
<211>  463
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  199

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460             


<210>  200
<211>  705
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  200

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Ile Gln Ser Pro Ser 
    130                 135                 140                 


Val Leu Ser Ala Ser Val Gly Asp Arg Val Thr Leu Asn Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Asn Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly 
                165                 170                 175     


Glu Ala Pro Lys Val Leu Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe 
    210                 215                 220                 


Gln His Tyr Thr Trp Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser 
            260                 265                 270         


Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser 
        275                 280                 285             


Asp Ser Ala Ala Trp Ser Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu 
    290                 295                 300                 


Glu Trp Leu Gly Ile Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Arg Tyr 
305                 310                 315                 320 


Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys 
                325                 330                 335     


Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg Trp His Ser Asp Lys His Trp Gly Phe Asp 
        355                 360                 365             


Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    370                 375                 380                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
385                 390                 395                 400 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                405                 410                 415     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            420                 425                 430         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        435                 440                 445             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    450                 455                 460                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
465                 470                 475                 480 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                485                 490                 495     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            500                 505                 510         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        515                 520                 525             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    530                 535                 540                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
545                 550                 555                 560 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                565                 570                 575     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            580                 585                 590         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        595                 600                 605             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    610                 615                 620                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
625                 630                 635                 640 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                645                 650                 655     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            660                 665                 670         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        675                 680                 685             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    690                 695                 700                 


Gly 
705 


<210>  201
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  201

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Phe Arg 
            20                  25                  30          


Asp Gly Ile Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Asp Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  202
<211>  699
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  202

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Ile Gln Ser Pro Ser 
    130                 135                 140                 


Val Leu Ser Ala Ser Val Gly Asp Arg Val Thr Leu Asn Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Asn Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly 
                165                 170                 175     


Glu Ala Pro Lys Val Leu Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe 
    210                 215                 220                 


Gln His Tyr Thr Trp Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
        275                 280                 285             


Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    370                 375                 380                 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
385                 390                 395                 400 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                405                 410                 415     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            420                 425                 430         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        435                 440                 445             


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
    450                 455                 460                 


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
465                 470                 475                 480 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
                485                 490                 495     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            500                 505                 510         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
        515                 520                 525             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    530                 535                 540                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
545                 550                 555                 560 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                565                 570                 575     


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            580                 585                 590         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        595                 600                 605             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    610                 615                 620                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
625                 630                 635                 640 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
                645                 650                 655     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            660                 665                 670         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        675                 680                 685             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 


<210>  203
<211>  700
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  203

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Leu Thr Gly Gly Gly Gly Ser Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Ile Gln Ser Pro 
    130                 135                 140                 


Ser Val Leu Ser Ala Ser Val Gly Asp Arg Val Thr Leu Asn Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asn Ile Asn Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Leu 
                165                 170                 175     


Gly Glu Ala Pro Lys Val Leu Ile Tyr Asn Thr Asn Asn Leu Gln Thr 
            180                 185                 190         


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Phe Gln His Tyr Thr Trp Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
        275                 280                 285             


Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    290                 295                 300                 


Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    370                 375                 380                 


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
385                 390                 395                 400 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                405                 410                 415     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            420                 425                 430         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        435                 440                 445             


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
    450                 455                 460                 


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
465                 470                 475                 480 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
                485                 490                 495     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            500                 505                 510         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
        515                 520                 525             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    530                 535                 540                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
545                 550                 555                 560 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                565                 570                 575     


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            580                 585                 590         


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        595                 600                 605             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    610                 615                 620                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
625                 630                 635                 640 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
                645                 650                 655     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            660                 665                 670         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        675                 680                 685             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700 


<210>  204
<211>  717
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  204

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Ile Gln Ser Pro Ser 
    130                 135                 140                 


Val Leu Ser Ala Ser Val Gly Asp Arg Val Thr Leu Asn Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Asn Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly 
                165                 170                 175     


Glu Ala Pro Lys Val Leu Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe 
    210                 215                 220                 


Gln His Tyr Thr Trp Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Ser Lys Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu 
                245                 250                 255     


Arg Asn Pro Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys 
            260                 265                 270         


Asn Glu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    290                 295                 300                 


Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala 
                325                 330                 335     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            340                 345                 350         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
385                 390                 395                 400 


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
                405                 410                 415     


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
            420                 425                 430         


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
        435                 440                 445             


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
    450                 455                 460                 


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
465                 470                 475                 480 


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
                485                 490                 495     


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
            500                 505                 510         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        515                 520                 525             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    530                 535                 540                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
545                 550                 555                 560 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
                565                 570                 575     


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            580                 585                 590         


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        595                 600                 605             


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    610                 615                 620                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
625                 630                 635                 640 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                645                 650                 655     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
            660                 665                 670         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        675                 680                 685             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    690                 695                 700                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
705                 710                 715         


<210>  205
<211>  705
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  205

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Ile Gln Ser Pro Ser 
    130                 135                 140                 


Val Leu Ser Ala Ser Val Gly Asp Arg Val Thr Leu Asn Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Asn Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly 
                165                 170                 175     


Glu Ala Pro Lys Val Leu Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe 
    210                 215                 220                 


Gln His Tyr Thr Trp Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Glu Gly Arg Thr Ala Thr Gly Gly Gly Gly Ser Leu Val Pro Arg 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser 
305                 310                 315                 320 


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                325                 330                 335     


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            340                 345                 350         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    370                 375                 380                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
385                 390                 395                 400 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                405                 410                 415     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            420                 425                 430         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        435                 440                 445             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    450                 455                 460                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
465                 470                 475                 480 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                485                 490                 495     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            500                 505                 510         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        515                 520                 525             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    530                 535                 540                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
545                 550                 555                 560 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                565                 570                 575     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            580                 585                 590         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        595                 600                 605             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    610                 615                 620                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
625                 630                 635                 640 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                645                 650                 655     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            660                 665                 670         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        675                 680                 685             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    690                 695                 700                 


Gly 
705 


<210>  206
<211>  710
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  206

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Ile Gln Ser Pro Ser 
    130                 135                 140                 


Val Leu Ser Ala Ser Val Gly Asp Arg Val Thr Leu Asn Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Asn Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly 
                165                 170                 175     


Glu Ala Pro Lys Val Leu Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly 
            180                 185                 190         


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe 
    210                 215                 220                 


Gln His Tyr Thr Trp Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg 
305                 310                 315                 320 


Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr 
        355                 360                 365             


Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
385                 390                 395                 400 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                405                 410                 415     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            420                 425                 430         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        435                 440                 445             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
    450                 455                 460                 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
465                 470                 475                 480 


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
                485                 490                 495     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            500                 505                 510         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        515                 520                 525             


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    530                 535                 540                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
545                 550                 555                 560 


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
                565                 570                 575     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            580                 585                 590         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
        595                 600                 605             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    610                 615                 620                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
625                 630                 635                 640 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                645                 650                 655     


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            660                 665                 670         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        675                 680                 685             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    690                 695                 700                 


Leu Ser Leu Ser Pro Gly 
705                 710 


<210>  207
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  207

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Leu Thr Gly Gly Gly Gly Ser Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly 
            180                 185                 190         


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
            260                 265                 270         


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
                325                 330                 335     


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
            340                 345                 350         


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
        355                 360                 365             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    370                 375                 380                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
385                 390                 395                 400 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                405                 410                 415     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
            420                 425                 430         


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
        435                 440                 445             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
    450                 455                 460                 


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
465                 470                 475                 480 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                485                 490                 495     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            500                 505                 510         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        515                 520                 525             


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    530                 535                 540                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
545                 550                 555                 560 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                565                 570                 575     


Pro Gly 
        


<210>  208
<211>  334
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  208

Asp Ile Gln Met Ile Gln Ser Pro Ser Val Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Asn Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Phe Gln His Tyr Thr Trp Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Leu 
            100                 105                 110         


Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu Leu Thr Gln 
        115                 120                 125             


Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys 
    130                 135                 140                 


Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala His Trp Tyr Gln Gln Lys 
145                 150                 155                 160 


Pro Gly Gln Ala Pro Val Val Val Ile Phe Tyr Asp Val Asn Arg Pro 
                165                 170                 175     


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 
            180                 185                 190         


Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr 
        195                 200                 205             


Cys Gln Ala Trp Trp Ser Ser Thr Pro Val Phe Gly Gly Gly Thr Lys 
    210                 215                 220                 


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
225                 230                 235                 240 


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
                245                 250                 255     


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
            260                 265                 270         


Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys 
        275                 280                 285             


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
    290                 295                 300                 


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu 
305                 310                 315                 320 


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
                325                 330                 


<210>  209
<211>  565
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  209

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Leu Val Pro Arg Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly 
                165                 170                 175     


Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg 
    210                 215                 220                 


Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
                245                 250                 255     


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            260                 265                 270         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        275                 280                 285             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    290                 295                 300                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
305                 310                 315                 320 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                325                 330                 335     


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            340                 345                 350         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        355                 360                 365             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    370                 375                 380                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
385                 390                 395                 400 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                405                 410                 415     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            420                 425                 430         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        435                 440                 445             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    450                 455                 460                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
465                 470                 475                 480 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                485                 490                 495     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            500                 505                 510         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        515                 520                 525             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    530                 535                 540                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
545                 550                 555                 560 


Ser Leu Ser Pro Gly 
                565 


<210>  210
<211>  322
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  210

Asp Ile Gln Met Ile Gln Ser Pro Ser Val Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Asn Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Phe Gln His Tyr Thr Trp Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Val Pro Arg Gly Ser Ser Tyr 
            100                 105                 110         


Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala 
        115                 120                 125             


Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala His Trp 
    130                 135                 140                 


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe Tyr Asp 
145                 150                 155                 160 


Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
                165                 170                 175     


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu 
            180                 185                 190         


Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val Phe Gly 
        195                 200                 205             


Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
    210                 215                 220                 


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
225                 230                 235                 240 


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
                245                 250                 255     


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
            260                 265                 270         


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
        275                 280                 285             


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
    290                 295                 300                 


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
305                 310                 315                 320 


Cys Ser 
        


<210>  211
<211>  568
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  211

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Arg Pro Asp Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val 
    50                  55                  60                  


Arg Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Met Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Pro Thr Arg Ala Gly Leu Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Leu Thr Leu Val Pro Arg Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met 
145                 150                 155                 160 


Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
                165                 170                 175     


Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                245                 250                 255     


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
            260                 265                 270         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        275                 280                 285             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    290                 295                 300                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
305                 310                 315                 320 


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
                325                 330                 335     


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
            340                 345                 350         


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        355                 360                 365             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    370                 375                 380                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
385                 390                 395                 400 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                405                 410                 415     


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
            420                 425                 430         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        435                 440                 445             


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
    450                 455                 460                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
465                 470                 475                 480 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                485                 490                 495     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            500                 505                 510         


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        515                 520                 525             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    530                 535                 540                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
545                 550                 555                 560 


Lys Ser Leu Ser Leu Ser Pro Gly 
                565             


<210>  212
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  212

Asp Ile Gln Met Ile Gln Ser Pro Ser Val Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Asn Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Phe Gln His Tyr Thr Trp Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Ser Leu Val Pro 
            100                 105                 110         


Arg Gly Ser Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val 
        115                 120                 125             


Ser Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn 
    130                 135                 140                 


Leu Pro Lys Tyr Tyr Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
145                 150                 155                 160 


Pro Val Val Val Ile Phe Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro 
                165                 170                 175     


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
            180                 185                 190         


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
        195                 200                 205             


Trp Ser Ser Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
    210                 215                 220                 


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
225                 230                 235                 240 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
                245                 250                 255     


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
            260                 265                 270         


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
        275                 280                 285             


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
    290                 295                 300                 


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
305                 310                 315                 320 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
                325                 330 


<210>  213
<211>  482
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  213

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
        35                  40                  45              


Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser 
    50                  55                  60                  


Ser Asp Ser Ala Ala Trp Ser Trp Ile Arg Gln Ser Pro Ser Arg Gly 
65                  70                  75                  80  


Leu Glu Trp Leu Gly Ile Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Arg 
                85                  90                  95      


Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser 
            100                 105                 110         


Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr 
        115                 120                 125             


Ala Val Tyr Tyr Cys Ala Arg Trp His Ser Asp Lys His Trp Gly Phe 
    130                 135                 140                 


Asp Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
145                 150                 155                 160 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
                165                 170                 175     


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            180                 185                 190         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        195                 200                 205             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    210                 215                 220                 


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
225                 230                 235                 240 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
                245                 250                 255     


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly 
        


<210>  214
<211>  476
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  214

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        35                  40                  45              


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    50                  55                  60                  


Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
65                  70                  75                  80  


Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp 
                85                  90                  95      


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            100                 105                 110         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        115                 120                 125             


Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  215
<211>  494
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  215

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Ser Lys Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu 
            20                  25                  30          


Leu Arg Asn Pro Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu 
        35                  40                  45              


Lys Asn Glu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    50                  55                  60                  


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
65                  70                  75                  80  


Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly 
                85                  90                  95      


Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr 
            100                 105                 110         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        115                 120                 125             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    130                 135                 140                 


Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly 
145                 150                 155                 160 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
                165                 170                 175     


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
            180                 185                 190         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        195                 200                 205             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    210                 215                 220                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
225                 230                 235                 240 


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
                245                 250                 255     


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
            260                 265                 270         


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 


<210>  216
<211>  482
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  216

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Gly Gly Gly Ser Leu Val Pro 
            20                  25                  30          


Arg Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly 
                85                  90                  95      


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        115                 120                 125             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe 
    130                 135                 140                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
145                 150                 155                 160 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
                165                 170                 175     


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            180                 185                 190         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        195                 200                 205             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    210                 215                 220                 


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
225                 230                 235                 240 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
                245                 250                 255     


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly 
        


<210>  217
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  217

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Gly Gly Arg Ser Gly Ser Gly Gly Arg Ser Gly Ser Glu Val 
            20                  25                  30          


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        35                  40                  45              


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met 
    50                  55                  60                  


Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
65                  70                  75                  80  


Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                85                  90                  95      


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
            100                 105                 110         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        115                 120                 125             


Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  218
<211>  463
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  218

Leu Pro His Ser His Arg Ala His Ser Leu Pro Pro Phe Asn Pro Arg 
1               5                   10                  15      


Gly Pro Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460             


<210>  219
<211>  482
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  219

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
        35                  40                  45              


Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser 
    50                  55                  60                  


Ser Asp Ser Ala Ala Trp Ser Trp Ile Arg Gln Ser Pro Ser Arg Gly 
65                  70                  75                  80  


Leu Glu Trp Leu Gly Ile Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Arg 
                85                  90                  95      


Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser 
            100                 105                 110         


Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr 
        115                 120                 125             


Ala Val Tyr Tyr Cys Ala Arg Trp His Ser Asp Lys His Trp Gly Phe 
    130                 135                 140                 


Asp Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
145                 150                 155                 160 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
                165                 170                 175     


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            180                 185                 190         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        195                 200                 205             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    210                 215                 220                 


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
225                 230                 235                 240 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
                245                 250                 255     


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly 
        


<210>  220
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  220

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Phe Arg 
            20                  25                  30          


Asp Gly Ile Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Asp Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  221
<211>  476
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  221

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        35                  40                  45              


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    50                  55                  60                  


Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
65                  70                  75                  80  


Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp 
                85                  90                  95      


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            100                 105                 110         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        115                 120                 125             


Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  222
<211>  494
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  222

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Ser Lys Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu 
            20                  25                  30          


Leu Arg Asn Pro Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu 
        35                  40                  45              


Lys Asn Glu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    50                  55                  60                  


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
65                  70                  75                  80  


Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly 
                85                  90                  95      


Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr 
            100                 105                 110         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        115                 120                 125             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    130                 135                 140                 


Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly 
145                 150                 155                 160 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
                165                 170                 175     


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
            180                 185                 190         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        195                 200                 205             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    210                 215                 220                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
225                 230                 235                 240 


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
                245                 250                 255     


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
            260                 265                 270         


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 


<210>  223
<211>  482
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  223

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Gly Gly Gly Ser Leu Val Pro 
            20                  25                  30          


Arg Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly 
                85                  90                  95      


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        115                 120                 125             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe 
    130                 135                 140                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
145                 150                 155                 160 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
                165                 170                 175     


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            180                 185                 190         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        195                 200                 205             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    210                 215                 220                 


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
225                 230                 235                 240 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
                245                 250                 255     


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly 
        


<210>  224
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  224

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Gly Gly Arg Ser Gly Ser Gly Gly Arg Ser Gly Ser Glu Val 
            20                  25                  30          


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        35                  40                  45              


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met 
    50                  55                  60                  


Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
65                  70                  75                  80  


Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                85                  90                  95      


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
            100                 105                 110         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        115                 120                 125             


Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  225
<211>  228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  225

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe 
        35                  40                  45              


Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Leu 
            100                 105                 110         


Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Gly Gln Pro Lys Ala Ala 
        115                 120                 125             


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
    130                 135                 140                 


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
145                 150                 155                 160 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
                165                 170                 175     


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
            180                 185                 190         


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
        195                 200                 205             


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
    210                 215                 220                 


Thr Glu Cys Ser 
225             


<210>  226
<211>  476
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  226

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        35                  40                  45              


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    50                  55                  60                  


Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
65                  70                  75                  80  


Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp 
                85                  90                  95      


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            100                 105                 110         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        115                 120                 125             


Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  227
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  227

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    50                  55                  60                  


Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
65                  70                  75                  80  


Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
    210                 215                 220                 


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
225                 230                 235                 240 


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  228
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  228

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Leu Val Pro Arg Gly Ser Glu Val 
            20                  25                  30          


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        35                  40                  45              


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met 
    50                  55                  60                  


Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
65                  70                  75                  80  


Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                85                  90                  95      


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
            100                 105                 110         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        115                 120                 125             


Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  229
<211>  470
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  229

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Ser Glu Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp 
    50                  55                  60                  


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg 
65                  70                  75                  80  


Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
            100                 105                 110         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr 
        115                 120                 125             


Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
145                 150                 155                 160 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  230
<211>  468
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  230

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Leu Val Pro Arg Gly Ser Gly Ser Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser 
65                  70                  75                  80  


Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr 
        115                 120                 125             


Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
225                 230                 235                 240 


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly 
465             


<210>  231
<211>  468
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  231

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Ser Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser 
65                  70                  75                  80  


Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr 
        115                 120                 125             


Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
225                 230                 235                 240 


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly 
465             


<210>  232
<211>  482
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  232

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Ser Thr Ala Thr Gly Gly Gly Gly Ser Leu Val Pro 
            20                  25                  30          


Ser Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly 
                85                  90                  95      


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        115                 120                 125             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe 
    130                 135                 140                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
145                 150                 155                 160 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
                165                 170                 175     


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            180                 185                 190         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        195                 200                 205             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    210                 215                 220                 


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
225                 230                 235                 240 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
                245                 250                 255     


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly 
        


<210>  233
<211>  479
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  233

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Gly Gly Gly Ser Leu Val Pro 
            20                  25                  30          


Arg Gly Ser Gly Gly Gly Gly Ser Leu Val Glu Ser Gly Gly Gly Leu 
        35                  40                  45              


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    50                  55                  60                  


Thr Phe Ser Ser Tyr Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys 
65                  70                  75                  80  


Gly Leu Glu Trp Val Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr 
                85                  90                  95      


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
            100                 105                 110         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        115                 120                 125             


Ala Val Tyr Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp 
    130                 135                 140                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
                245                 250                 255     


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 


<210>  234
<211>  442
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  234

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
            180                 185                 190         


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440         


<210>  235
<211>  246
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  235

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro 
        35                  40                  45              


Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr 
    50                  55                  60                  


Tyr Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val 
65                  70                  75                  80  


Ile Phe Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
                85                  90                  95      


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln 
            100                 105                 110         


Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr 
        115                 120                 125             


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
    130                 135                 140                 


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
145                 150                 155                 160 


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
                165                 170                 175     


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
            180                 185                 190         


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
        195                 200                 205             


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
    210                 215                 220                 


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
225                 230                 235                 240 


Ala Pro Thr Glu Cys Ser 
                245     


<210>  236
<211>  240
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  236

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Ser Ser Tyr Glu Leu 
            20                  25                  30          


Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile 
        35                  40                  45              


Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala His Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe Tyr Asp Val Asn 
65                  70                  75                  80  


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
                85                  90                  95      


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp 
            100                 105                 110         


Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
    130                 135                 140                 


Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
                165                 170                 175     


Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro 
            180                 185                 190         


Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
        195                 200                 205             


Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr 
    210                 215                 220                 


His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235                 240 


<210>  237
<211>  240
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  237

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Ser Leu Val Pro Ser Gly Ser Gly Gly Ser Ser Tyr Glu Leu 
            20                  25                  30          


Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile 
        35                  40                  45              


Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala His Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe Tyr Asp Val Asn 
65                  70                  75                  80  


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
                85                  90                  95      


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp 
            100                 105                 110         


Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
    130                 135                 140                 


Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
                165                 170                 175     


Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro 
            180                 185                 190         


Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
        195                 200                 205             


Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr 
    210                 215                 220                 


His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235                 240 


<210>  238
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  238

Ala Ala Arg Tyr Trp Asp Tyr Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly 
    50                  


<210>  239
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  239

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
        35                  40                  45              


Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val 
    50                  55                  60              


<210>  240
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  240

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        35                  40                  45              


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    50                  55                  60              


<210>  241
<211>  82
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  241

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Ser Lys Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu 
            20                  25                  30          


Leu Arg Asn Pro Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu 
        35                  40                  45              


Lys Asn Glu Ser Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    50                  55                  60                  


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
65                  70                  75                  80  


Tyr Gly 
        


<210>  242
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  242

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Gly Gly Gly Ser Leu Val Pro 
            20                  25                  30          


Arg Gly Ser Gly Gly Gly Gly Leu Val Glu Ser Gly Gly Gly Leu Val 
        35                  40                  45              


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
    50                  55                  60                  


Phe Ser Ser Tyr Gly 
65                  


<210>  243
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  243

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        35                  40                  45              


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    50                  55                  60              


<210>  244
<211>  73
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  244

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Gly Gly Gly Ser Leu Val Pro 
            20                  25                  30          


Arg Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
65                  70              


<210>  245
<211>  67
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  245

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        35                  40                  45              


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    50                  55                  60                  


Ser Tyr Gly 
65          


<210>  246
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  246

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    50                  55                  60                  


<210>  247
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  247

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Leu Val Pro Arg Gly Ser Glu Val 
            20                  25                  30          


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        35                  40                  45              


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    50                  55                  60              


<210>  248
<211>  61
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  248

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Ser Glu Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    50                  55                  60      


<210>  249
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  249

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Leu Val Pro Arg Gly Ser Gly Ser Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    50                  55                  


<210>  250
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  250

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Ser Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    50                  55                  


<210>  251
<211>  73
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  251

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Ser Thr Ala Thr Gly Gly Gly Gly Ser Leu Val Pro 
            20                  25                  30          


Ser Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
65                  70              


<210>  252
<211>  70
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  252

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Gly Gly Gly Ser Leu Val Pro 
            20                  25                  30          


Arg Gly Ser Gly Gly Gly Gly Ser Leu Val Glu Ser Gly Gly Gly Leu 
        35                  40                  45              


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    50                  55                  60                  


Thr Phe Ser Ser Tyr Gly 
65                  70  


<210>  253
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  253

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
            20                  25                  30  


<210>  254
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  254

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Glu Gly Arg Thr Ala Thr Gly Ser Leu Val Pro Arg Gly Ser 
            20                  25                  30          


Gly Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
        35                  40                  45              


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
    50                  55                  60                  


<210>  255
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  255

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Ser Asp Ile Val Met 
            20                  25                  30          


Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
        35                  40                  45              


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
    50                  55              


<210>  256
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  256

Ala Ala Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly Thr Pro Val 
1               5                   10                  15      


Gly Gly Ser Leu Val Pro Ser Gly Ser Gly Gly Ser Asp Ile Val Met 
            20                  25                  30          


Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
        35                  40                  45              


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
    50                  55              


