
                                SEQUENCE LISTING

<110> The Regents of the University of California
      Bajaj, S. Paul

<120> DUAL REACTIVITY POTENT KUNITZ INHIBITOR OF FIBRINOLYSIS
  

<130> 720156.403WO

<140> US
<141> 2014-03-14

<150> US 61/922,026
<151> 2013-12-30

<150> US 61/793,131                 
<151> 2013-03-15  

<160> 53

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 57
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = Tyr, Ser, Thr, Asn, or Asp

<220>
<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Lys, Arg, Ser or Thr

<400> 1
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Xaa Gly Pro Cys Arg Ala
 1               5                  10                  15
Xaa Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg
    50                  55

<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 2
Ile Xaa Lys Val Xaa Lys
 1               5

<210> 3
<211> 60
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 3
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys
    50                  55                  60

<210> 4
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 4
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys
    50                  55                  60

<210> 5
<211> 60
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 5
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys
    50                  55                  60

<210> 6
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 6
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys
    50                  55                  60

<210> 7
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 7
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys
    50                  55                  60

<210> 8
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 8
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys
    50                  55                  60

<210> 9
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 9
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys
    50                  55                  60

<210> 10
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 10
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys
    50                  55                  60

<210> 11
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (62)...(62)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 11
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val Xaa Lys
    50                  55                  60

<210> 12
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (62)...(62)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 12
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val Xaa Lys
    50                  55                  60

<210> 13
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (63)...(63)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 13
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val Xaa Lys
    50                  55                  60

<210> 14
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (63)...(63)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 14
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val Xaa Lys
    50                  55                  60

<210> 15
<211> 60
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 15
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys
    50                  55                  60

<210> 16
<211> 60
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 16
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys
    50                  55                  60

<210> 17
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 17
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys
    50                  55                  60

<210> 18
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 18
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys
    50                  55                  60

<210> 19
<211> 58
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 19
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala
 1               5                  10                  15
Leu Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile
    50                  55

<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 20
Ile Xaa Lys Val Xaa
 1               5

<210> 21
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 21
Ile Xaa Lys Val
 1

<210> 22
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 22
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val
    50                  55                  60

<210> 23
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (62)...(62)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 23
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val Xaa
    50                  55                  60

<210> 24
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 24
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val
    50                  55                  60

<210> 25
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (62)...(62)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 25
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val Xaa
    50                  55                  60

<210> 26
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 26
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val
    50                  55                  60

<210> 27
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (63)...(63)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 27
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val Xaa
    50                  55                  60

<210> 28
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 28
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val
    50                  55                  60

<210> 29
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (63)...(63)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<400> 29
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Thr Gly Pro Cys Arg
 1               5                  10                  15
Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Val Xaa
    50                  55                  60

<210> 30
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = any amino acid

<400> 30
Ile Xaa Lys Xaa
 1

<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = any amino acid

<220>
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = any amino acid

<400> 31
Ile Xaa Lys Xaa Xaa
 1               5

<210> 32
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = Tyr, Ser, Thr, Asn, or Asp

<220>
<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Lys, Arg, Ser or Thr

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (61)...(61)
<223> Xaa = any amino acid

<400> 32
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Xaa Gly Pro Cys Arg Ala
 1               5                  10                  15
Xaa Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Xaa
    50                  55                  60

<210> 33
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = Tyr, Ser, Thr, Asn, or Asp

<220>
<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Lys, Arg, Ser or Thr

<220>
<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (61)...(61)
<223> Xaa = Any amino acid

<220>
<221> VARIANT        
<222> (62)...(62)
<223> Xaa = any amino acid

<400> 33
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Xaa Gly Pro Cys Arg Ala
 1               5                  10                  15
Xaa Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Xaa Xaa
    50                  55                  60

<210> 34
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (12)...(12)
<223> Xaa = Tyr, Ser, Thr, Asn, or Asp

<220>
<221> VARIANT        
<222> (18)...(18)
<223> Xaa = Lys, Arg, Ser or Thr

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (62)...(62)
<223> Xaa = any amino acid

<400> 34
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Xaa Gly Pro Cys Arg
 1               5                  10                  15
Ala Xaa Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Xaa
    50                  55                  60

<210> 35
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<220>
<221> VARIANT        
<222> (12)...(12)
<223> Xaa = Tyr, Ser, Thr, Asn or Asp

<220>
<221> VARIANT        
<222> (18)...(18)
<223> Xaa = Lys, Arg, Ser or Thr

<220>
<221> VARIANT        
<222> (60)...(60)
<223> Xaa = Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met,
      Asn, Pro, Gln, Ser, Thr, Val or Tyr

<220>
<221> VARIANT        
<222> (62)...(62)
<223> Xaa = any amino acid

<220>
<221> VARIANT        
<222> (63)...(63)
<223> Xaa = any amino acid

<400> 35
Met Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Xaa Gly Pro Cys Arg
 1               5                  10                  15
Ala Xaa Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg
            20                  25                  30
Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr
        35                  40                  45
Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Xaa Lys Xaa Xaa
    50                  55                  60

<210> 36
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Illustrative spacer

<400> 36
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp
 1               5                  10

<210> 37
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Illustrative spacer

<400> 37
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser
 1               5                  10                  15
Leu Asp


<210> 38
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible polylinker

<400> 38
Gly Gly Gly Gly Ser
 1               5


<210> 39
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 39
Ile Glu Lys Val Pro Lys
 1               5

<210> 40
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 40
Ile Glu Lys Val Pro
 1               5

<210> 41
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 41
Ile Glu Lys Val
 1

<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 42
Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys Val
 1               5                  10

<210> 43
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 43
Asp Ala Ala Gln Glu Pro Thr Gly Asn Asn Ala Glu
 1               5                  10

<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 44
Glu Lys Val Pro Lys Val
 1               5

<210> 45
<211> 58
<212> PRT
<213> Bovine sp.

<400> 45
Arg Pro Asp Phe Cys Leu Glu Pro Pro Tyr Thr Gly Pro Cys Lys Ala
 1               5                  10                  15
Arg Ile Ile Arg Tyr Phe Tyr Asn Ala Lys Ala Gly Leu Cys Gln Thr
            20                  25                  30
Phe Val Tyr Gly Gly Cys Arg Ala Lys Arg Asn Asn Phe Lys Ser Ala
        35                  40                  45
Glu Asp Cys Met Arg Thr Cys Gly Gly Ala
    50                  55

<210> 46
<211> 77
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 46
Gly Ser His Met Asp Ala Ala Gln Glu Pro Thr Gly Asn Asn Ala Glu
 1               5                  10                  15
Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala Arg Leu Leu
            20                  25                  30
Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln Phe Leu Tyr
        35                  40                  45
Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp Glu Ala Cys
    50                  55                  60
Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys Val
65                  70                  75

<210> 47
<211> 65
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 47
Gly Asn Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys
 1               5                  10                  15
Arg Ala Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys
            20                  25                  30
Arg Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr
        35                  40                  45
Thr Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro
    50                  55                  60
Lys
65

<210> 48
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 48
Asn Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala
 1               5                  10                  15
Arg Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln
            20                  25                  30
Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp
        35                  40                  45
Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys
    50                  55                  60

<210> 49
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 49
Gly Asn Asn Ala Glu Ile
 1               5

<210> 50
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 50
Asn Ala Glu Ile
 1

<210> 51
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 51
Glu Lys Val Pro Lys
 1               5

<210> 52
<211> 76
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 52
Gly Ser His Met Asp Ala Ala Gln Glu Pro Thr Gly Asn Asn Ala Glu
 1               5                  10                  15
Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala Arg Leu Leu
            20                  25                  30
Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln Phe Leu Tyr
        35                  40                  45
Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp Glu Ala Cys
    50                  55                  60
Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys
65                  70                  75

<210> 53
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Engineered polypeptide

<400> 53
Gly Ser His Met Asp Ala Ala Gln Glu Pro
 1               5                  10