                               SEQUENCE LISTING

<110> SANOFI PASTEUR BIOLOGICS, LLC
      VALNEVA
 
<120> ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND METHODS OF 
      USING THE SAME

<130> 0171.0002-PCT

<140>
<141>

<150> 61/794,071
<151> 2013-03-15

<160> 340   

<170> PatentIn version 3.5

<210> 1
<211> 1416
<212> DNA
<213> Homo sapiens

<400> 1
atgaaacatc tgtggttctt ccttctcctg gtggcagctc ccagatgggt cctgtcccag       60

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcagtact tactactgga gctggatccg gcagtcccca      180

gggaagggac tggagtggat ggggtatatc tattatagtg ggagcaccaa ctacaacccc      240

tccctcgaga gtcgggtcac catagcagtg gacacgtcca agaatcagtt ctccctgcag      300

ttgacctctg tgactgctgc ggacacggcc gtgtattact gtgcgagagg agcggcggag      360

tggctacggt tcagggggtt ctttgactcc tggggccagg gaaccctggt caccgtctcc      420

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210> 2
<211> 471
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Thr Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Glu Ser Arg Val Thr Ile Ala Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Gln Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Ala Ala Glu Trp Leu Arg Phe Arg Gly Phe Phe 
        115                 120                 125             


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210> 3
<211> 705
<212> DNA
<213> Homo sapiens

<400> 3
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga gaccaccgga       60

gaaaatgtgt tgacgcagtc tccagggacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca cagtgttacc aacaacttct tagcctggta ccagcaaaaa      180

cctggccagg ctcccaggct cctcatctat ggtgtgtcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag caatatggtg tctcagggac ttttggccag      360

gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      705


<210> 4
<211> 234
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Glu Thr Thr Gly Glu Asn Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser His Ser 
        35                  40                  45              


Val Thr Asn Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Val Ser Gly Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 5
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210> 6
<211> 10
<212> PRT
<213> Homo sapiens

<400> 6
Gly Gly Ser Ile Ser Thr Tyr Tyr Trp Ser 
1               5                   10  


<210> 7
<211> 14
<212> PRT
<213> Homo sapiens

<400> 7
Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210> 8
<211> 9
<212> PRT
<213> Homo sapiens

<400> 8
Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn 
1               5                   


<210> 9
<211> 39
<212> PRT
<213> Homo sapiens

<400> 9
Tyr Asn Pro Ser Leu Glu Ser Arg Val Thr Ile Ala Val Asp Thr Ser 
1               5                   10                  15      


Lys Asn Gln Phe Ser Leu Gln Leu Thr Ser Val Thr Ala Ala Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210> 10
<211> 14
<212> PRT
<213> Homo sapiens

<400> 10
Gly Ala Ala Glu Trp Leu Arg Phe Arg Gly Phe Phe Asp Ser 
1               5                   10                  


<210> 11
<211> 11
<212> PRT
<213> Homo sapiens

<400> 11
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210> 12
<211> 23
<212> PRT
<213> Homo sapiens

<400> 12
Glu Asn Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210> 13
<211> 12
<212> PRT
<213> Homo sapiens

<400> 13
Arg Ala Ser His Ser Val Thr Asn Asn Phe Leu Ala 
1               5                   10          


<210> 14
<211> 15
<212> PRT
<213> Homo sapiens

<400> 14
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 15
<211> 7
<212> PRT
<213> Homo sapiens

<400> 15
Gly Val Ser Ser Arg Ala Thr 
1               5           


<210> 16
<211> 32
<212> PRT
<213> Homo sapiens

<400> 16
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210> 17
<211> 12
<212> PRT
<213> Homo sapiens

<400> 17
Ala Ala Trp Asp Asp Ser Leu Thr Gly Leu Tyr Val 
1               5                   10          


<210> 18
<211> 20
<212> PRT
<213> Homo sapiens

<400> 18
Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala Asn 
1               5                   10                  15      


Pro Thr Val Thr 
            20  


<210> 19
<211> 1416
<212> DNA
<213> Homo sapiens

<400> 19
atgaaacatc tgtggttctt ccttctcctg gtggcagccc ccagatgggt cctgtcccag       60

gtgcacctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcacc      120

tgcactgtct ccggtgactc catcagtact tactactgga gctggatccg gcagccccca      180

gggaagggac tggagtggat tgggtatgtc tattacactg ggagcaccaa ctacagccct      240

tccctcgagg gtcgagtcac cttatcagta gacacgtcca agaaccagtt ctccctgaag      300

ttgaattctg tgagtgctgc ggacacggcc gtgtattact gtgcgagagg cgcggcggag      360

tggctacgat tcagggggtt ctttgactac tggggccagg gaatcctggt ctccgtctcc      420

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210> 20
<211> 471
<212> PRT
<213> Homo sapiens

<400> 20
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
        35                  40                  45              


Ser Thr Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Val Tyr Tyr Thr Gly Ser Thr Asn Tyr Ser Pro 
65                  70                  75                  80  


Ser Leu Glu Gly Arg Val Thr Leu Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Asn Ser Val Ser Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Ala Ala Glu Trp Leu Arg Phe Arg Gly Phe Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Ile Leu Val Ser Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210> 21
<211> 705
<212> DNA
<213> Homo sapiens

<400> 21
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaagttgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgta gggccagtca gagtgttacc aacggcttct tagcctggta ccagcagaaa      180

cctggccagg ctcccagggt cctcatctat ggtgcgtcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcaatgta ttactgtcag cagtatggtc tctcagggac ttttggccag      360

gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      705


<210> 22
<211> 234
<212> PRT
<213> Homo sapiens

<400> 22
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Thr Asn Gly Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Val Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Leu Ser Gly Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 23
<211> 25
<212> PRT
<213> Homo sapiens

<400> 23
Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210> 24
<211> 10
<212> PRT
<213> Homo sapiens

<400> 24
Gly Asp Ser Ile Ser Thr Tyr Tyr Trp Ser 
1               5                   10  


<210> 25
<211> 14
<212> PRT
<213> Homo sapiens

<400> 25
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210> 26
<211> 9
<212> PRT
<213> Homo sapiens

<400> 26
Tyr Val Tyr Tyr Thr Gly Ser Thr Asn 
1               5                   


<210> 27
<211> 39
<212> PRT
<213> Homo sapiens

<400> 27
Tyr Ser Pro Ser Leu Glu Gly Arg Val Thr Leu Ser Val Asp Thr Ser 
1               5                   10                  15      


Lys Asn Gln Phe Ser Leu Lys Leu Asn Ser Val Ser Ala Ala Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210> 28
<211> 14
<212> PRT
<213> Homo sapiens

<400> 28
Gly Ala Ala Glu Trp Leu Arg Phe Arg Gly Phe Phe Asp Tyr 
1               5                   10                  


<210> 29
<211> 11
<212> PRT
<213> Homo sapiens

<400> 29
Trp Gly Gln Gly Ile Leu Val Ser Val Ser Ser 
1               5                   10      


<210> 30
<211> 23
<212> PRT
<213> Homo sapiens

<400> 30
Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210> 31
<211> 12
<212> PRT
<213> Homo sapiens

<400> 31
Arg Ala Ser Gln Ser Val Thr Asn Gly Phe Leu Ala 
1               5                   10          


<210> 32
<211> 15
<212> PRT
<213> Homo sapiens

<400> 32
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Val Leu Ile Tyr 
1               5                   10                  15  


<210> 33
<211> 7
<212> PRT
<213> Homo sapiens

<400> 33
Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210> 34
<211> 32
<212> PRT
<213> Homo sapiens

<400> 34
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys 
            20                  25                  30          


<210> 35
<211> 8
<212> PRT
<213> Homo sapiens

<400> 35
Gln Gln Tyr Gly Leu Ser Gly Thr 
1               5               


<210> 36
<211> 10
<212> PRT
<213> Homo sapiens

<400> 36
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210> 37
<211> 1398
<212> DNA
<213> Homo sapiens

<400> 37
atgcaactgc tggagtctgg gggaggcttg gtgaagcctg gggggtccct tagactctcc       60

tgtgcagcct ctggattcac tttcagtaac gcctggatga gttgggtccg ccagggtcca      120

gggaaggggc tggaatgggt tggccgtatt aaaagtaaaa ctgatggtgg gacaacagac      180

tacgctgcac ccgtgaaagg cagattcagc atctcaagaa atgattcaaa taacacgctg      240

tttctgcaaa tgaacagcct gaaaaccgag gacacagccg tatattactg taccacaggt      300

cctcaaattg tagttgtagc aggtgctacc agtcgggacc agcctaacta ctactactac      360

ggtttggacg tctggggcct agggaccacg gtcaccgtct cgtcagcctc caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgggtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctccgg gtaaatga                                                   1398


<210> 38
<211> 465
<212> PRT
<213> Homo sapiens

<400> 38
Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala Trp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Ser Ile Ser Arg Asn Asp Ser Asn Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Thr Thr Gly Pro Gln Ile Val Val Val Ala Gly Ala Thr Ser Arg 
            100                 105                 110         


Asp Gln Pro Asn Tyr Tyr Tyr Tyr Gly Leu Asp Val Trp Gly Leu Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210> 39
<211> 711
<212> DNA
<213> Homo sapiens

<400> 39
atggccagct tccctctcct cctcaccctc ctcactcact gtgcagggtc ctgggcccag       60

tctgtgctga ctcagccacc ctcagcgtct gggacccccg ggcagagggt caccatctct      120

tgttctggaa gcagctccaa catcggcatt aatactgtaa actggtacca gcagctccca      180

ggaacggccc ccaaactcct catatataag agtaatctgc gaccctcagg ggtccctgac      240

cgattctctg gctccaagtc tggcacctca gcctccctgg ccatcagtgg gctccggtct      300

gaggatgagg ctgattatta ctgtgcggca tgggatgaca gcctgactgg tctttatgtc      360

ttcggaactg ggaccaaggt caccgtccta ggtcagccca aggccaaccc cactgtcact      420

ctgttcccgc cctcctctga ggagctccaa gccaacaagg ccacactagt gtgtctgatc      480

agtgacttct acccgggagc tgtgacagtg gcttggaagg cagatggcag ccccgtcaag      540

gcgggagtgg agacgaccaa accctccaaa cagagcaaca acaagtacgc ggccagcagc      600

tacctgagcc tgacgcccga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      660

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata g               711


<210> 40
<211> 236
<212> PRT
<213> Homo sapiens

<400> 40
Met Ala Ser Phe Pro Leu Leu Leu Thr Leu Leu Thr His Cys Ala Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ile Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ser Asn Leu Arg Pro Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
                85                  90                  95      


Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
            100                 105                 110         


Asp Ser Leu Thr Gly Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210> 41
<211> 24
<212> PRT
<213> Homo sapiens

<400> 41
Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  


<210> 42
<211> 10
<212> PRT
<213> Homo sapiens

<400> 42
Gly Phe Thr Phe Ser Asn Ala Trp Met Ser 
1               5                   10  


<210> 43
<211> 14
<212> PRT
<213> Homo sapiens

<400> 43
Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210> 44
<211> 12
<212> PRT
<213> Homo sapiens

<400> 44
Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp 
1               5                   10          


<210> 45
<211> 39
<212> PRT
<213> Homo sapiens

<400> 45
Tyr Ala Ala Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asn Asp Ser 
1               5                   10                  15      


Asn Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Thr Thr 
        35                  


<210> 46
<211> 8
<212> PRT
<213> Homo sapiens

<400> 46
Gly Pro Gln Ile Val Val Val Ala 
1               5               


<210> 47
<211> 28
<212> PRT
<213> Homo sapiens

<400> 47
Gly Ala Thr Ser Arg Asp Gln Pro Asn Tyr Tyr Tyr Tyr Gly Leu Asp 
1               5                   10                  15      


Val Trp Gly Leu Gly Thr Thr Val Thr Val Ser Ser 
            20                  25              


<210> 48
<211> 22
<212> PRT
<213> Homo sapiens

<400> 48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys 
            20          


<210> 49
<211> 13
<212> PRT
<213> Homo sapiens

<400> 49
Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn Thr Val Asn 
1               5                   10              


<210> 50
<211> 15
<212> PRT
<213> Homo sapiens

<400> 50
Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 51
<211> 7
<212> PRT
<213> Homo sapiens

<400> 51
Lys Ser Asn Leu Arg Pro Ser 
1               5           


<210> 52
<211> 32
<212> PRT
<213> Homo sapiens

<400> 52
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210> 53
<211> 12
<212> PRT
<213> Homo sapiens

<400> 53
Ala Ala Trp Asp Asp Ser Leu Thr Gly Leu Tyr Val 
1               5                   10          


<210> 54
<211> 20
<212> PRT
<213> Homo sapiens

<400> 54
Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala Asn 
1               5                   10                  15      


Pro Thr Val Thr 
            20  


<210> 55
<211> 1431
<212> DNA
<213> Homo sapiens

<400> 55
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcacctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcaacct ttggactcaa cttcagtgac tatggttttc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttaca tcatatgatg gaagcaacaa atactacgca      240

gaattcgtga agggccgatt caccatctcc agagacaatt acaagaatac ggtgtatctg      300

caaatgaaca gcctgagact tgaggacacg gctgtgtatt actgtgcgag agatctcgcc      360

ccatacaatt tttggagtgg ttatgggaat aattggttcg acccctgggg ccagggaacc      420

ctggtcaccg tctcctcagc ctccaccaag ggcccatcgg tcttccccct ggcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgg gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1431


<210> 56
<211> 476
<212> PRT
<213> Homo sapiens

<400> 56
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Thr Phe Gly Leu Asn Phe 
        35                  40                  45              


Ser Asp Tyr Gly Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Thr Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Glu Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Leu Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Leu Ala Pro Tyr Asn Phe Trp Ser Gly Tyr 
        115                 120                 125             


Gly Asn Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210> 57
<211> 711
<212> DNA
<213> Homo sapiens

<400> 57
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttact ggcacctcct tagcctggtt ccagcagaaa      180

cctggccagg ctccccggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctag actcactttc      360

ggcggaggga ccaaggtgga gatcaaacga actgtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta g               711


<210> 58
<211> 236
<212> PRT
<213> Homo sapiens

<400> 58
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Thr Gly Thr Ser Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210> 59
<211> 25
<212> PRT
<213> Homo sapiens

<400> 59
Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Phe 
            20                  25  


<210> 60
<211> 10
<212> PRT
<213> Homo sapiens

<400> 60
Gly Leu Asn Phe Ser Asp Tyr Gly Phe His 
1               5                   10  


<210> 61
<211> 14
<212> PRT
<213> Homo sapiens

<400> 61
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210> 62
<211> 9
<212> PRT
<213> Homo sapiens

<400> 62
Val Thr Ser Tyr Asp Gly Ser Asn Lys 
1               5                   


<210> 63
<211> 40
<212> PRT
<213> Homo sapiens

<400> 63
Tyr Tyr Ala Glu Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Tyr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Leu Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40  


<210> 64
<211> 18
<212> PRT
<213> Homo sapiens

<400> 64
Asp Leu Ala Pro Tyr Asn Phe Trp Ser Gly Tyr Gly Asn Asn Trp Phe 
1               5                   10                  15      


Asp Pro 
        


<210> 65
<211> 11
<212> PRT
<213> Homo sapiens

<400> 65
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210> 66
<211> 23
<212> PRT
<213> Homo sapiens

<400> 66
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210> 67
<211> 12
<212> PRT
<213> Homo sapiens

<400> 67
Arg Ala Ser Gln Ser Val Thr Gly Thr Ser Leu Ala 
1               5                   10          


<210> 68
<211> 15
<212> PRT
<213> Homo sapiens

<400> 68
Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 69
<211> 7
<212> PRT
<213> Homo sapiens

<400> 69
Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210> 70
<211> 32
<212> PRT
<213> Homo sapiens

<400> 70
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210> 71
<211> 10
<212> PRT
<213> Homo sapiens

<400> 71
Gln Gln Tyr Gly Ser Ser Pro Arg Leu Thr 
1               5                   10  


<210> 72
<211> 10
<212> PRT
<213> Homo sapiens

<400> 72
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210> 73
<211> 1431
<212> DNA
<213> Homo sapiens

<400> 73
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcacctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcaacct ttggactcaa cttcagtgac tatggttttc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttaca tcatatgatg gaagcaacaa atactacgca      240

gaattcgtga agggccgatt caccatctcc agagacaatt acaagaatac ggtgtatctg      300

caaatgaaca gcctgagact tgaggacacg gctgtgtatt actgtgcgag agatctcgcc      360

ccatacaatt tttggagtgg ttatgggaat aattggttcg acccctgggg ccagggaacc      420

ctggtcaccg tctcctcagc ctccaccaag ggcccatcgg tcttccccct ggcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgg gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1431


<210> 74
<211> 476
<212> PRT
<213> Homo sapiens

<400> 74
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Thr Phe Gly Leu Asn Phe 
        35                  40                  45              


Ser Asp Tyr Gly Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Thr Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Glu Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Leu Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Leu Ala Pro Tyr Asn Phe Trp Ser Gly Tyr 
        115                 120                 125             


Gly Asn Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210> 75
<211> 705
<212> DNA
<213> Homo sapiens

<400> 75
atggaagccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccactgga       60

gaaatagtga tgacgcagtc tccagccacc ctgtctgtct ctccaggaga aagagccacc      120

ctctcctgca gggccagtca gagtattagc agcaacttag cctggtacca gcagaaacct      180

ggccaggctc ccagactcct catctatgat gcatccacca gggccactgg tatcccagcc      240

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      300

gaagattttg cagtttatta ctgtcagcaa tacaatgact ggcttgtgac gttcggccaa      360

gggaccaaag tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      705


<210> 76
<211> 234
<212> PRT
<213> Homo sapiens

<400> 76
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn 
            100                 105                 110         


Asp Trp Leu Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210> 77
<211> 25
<212> PRT
<213> Homo sapiens

<400> 77
Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Phe 
            20                  25  


<210> 78
<211> 10
<212> PRT
<213> Homo sapiens

<400> 78
Gly Leu Asn Phe Ser Asp Tyr Gly Phe His 
1               5                   10  


<210> 79
<211> 14
<212> PRT
<213> Homo sapiens

<400> 79
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210> 80
<211> 9
<212> PRT
<213> Homo sapiens

<400> 80
Val Thr Ser Tyr Asp Gly Ser Asn Lys 
1               5                   


<210> 81
<211> 40
<212> PRT
<213> Homo sapiens

<400> 81
Tyr Tyr Ala Glu Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Tyr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Leu Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40  


<210> 82
<211> 18
<212> PRT
<213> Homo sapiens

<400> 82
Asp Leu Ala Pro Tyr Asn Phe Trp Ser Gly Tyr Gly Asn Asn Trp Phe 
1               5                   10                  15      


Asp Pro 
        


<210> 83
<211> 11
<212> PRT
<213> Homo sapiens

<400> 83
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210> 84
<211> 23
<212> PRT
<213> Homo sapiens

<400> 84
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210> 85
<211> 11
<212> PRT
<213> Homo sapiens

<400> 85
Arg Ala Ser Gln Ser Ile Ser Ser Asn Leu Ala 
1               5                   10      


<210> 86
<211> 15
<212> PRT
<213> Homo sapiens

<400> 86
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 87
<211> 7
<212> PRT
<213> Homo sapiens

<400> 87
Asp Ala Ser Thr Arg Ala Thr 
1               5           


<210> 88
<211> 32
<212> PRT
<213> Homo sapiens

<400> 88
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210> 89
<211> 9
<212> PRT
<213> Homo sapiens

<400> 89
Gln Gln Tyr Asn Asp Trp Leu Val Thr 
1               5                   


<210> 90
<211> 10
<212> PRT
<213> Homo sapiens

<400> 90
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210> 91
<211> 1413
<212> DNA
<213> Homo sapiens

<400> 91
atgaaacacc tgtggttctt cgtcctcctg gtggcagctc ccagatgggt cctgtcccag       60

gtgcaactac tgcagggggg cgcaggactg ttgaagcctt cggagaccct gtccctcacg      120

tgcgctgtct atggtgggtc ctttagtgaa cactattgga gttggatccg ccagccccca      180

gggaaggggc tggagtggat tggggaaatc aattatggtg gaaacaccaa ctacaacccg      240

tccctcgaga gtcgaatctc catctcagtg gacacatcaa agaaccaggt cttcctgaga      300

gtgagatttg tgacagctgc ggacacggct gtgtattttt gttcgggagg ccggcgagca      360

gcagtacatg gccggacttt tgctatctgg ggccaaggga caatggtcac cgtctcttca      420

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      780

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      960

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1140

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggtaaa tga                                  1413


<210> 92
<211> 470
<212> PRT
<213> Homo sapiens

<400> 92
Met Lys His Leu Trp Phe Phe Val Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Leu Gln Gly Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe 
        35                  40                  45              


Ser Glu His Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Tyr Gly Gly Asn Thr Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Glu Ser Arg Ile Ser Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Val Phe Leu Arg Val Arg Phe Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Phe Cys Ser Gly Gly Arg Arg Ala Ala Val His Gly Arg Thr Phe Ala 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210> 93
<211> 720
<212> DNA
<213> Homo sapiens

<400> 93
atgaggctcc ctgctcagct cctggggctg ctaatgctct gggtctccgg gtccagtggg       60

gatattgtga tgacgcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc      120

atctcctgca ggtctagtca gagcctgctt catactaatg gaaacaacta tttggtatgg      180

tatctgcaga agccagggca ggctccacat ctcctgatct atctgggatc taatcgggcc      240

tccggggtcc ctggcaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      300

agcagagtgg aggtcgagga tgttggggtt tattactgca tgcaatctct acaaactcct      360

cccacttttg gccaggggac caagctggag atcaaacgaa ctgtggctgc accatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      720


<210> 94
<211> 239
<212> PRT
<213> Homo sapiens

<400> 94
Met Arg Leu Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp Val Ser 
1               5                   10                  15      


Gly Ser Ser Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Thr Asn Gly Asn Asn Tyr Leu Val Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro His Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Val Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ser Leu Gln Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210> 95
<211> 25
<212> PRT
<213> Homo sapiens

<400> 95
Gln Val Gln Leu Leu Gln Gly Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr 
            20                  25  


<210> 96
<211> 10
<212> PRT
<213> Homo sapiens

<400> 96
Gly Gly Ser Phe Ser Glu His Tyr Trp Ser 
1               5                   10  


<210> 97
<211> 14
<212> PRT
<213> Homo sapiens

<400> 97
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210> 98
<211> 9
<212> PRT
<213> Homo sapiens

<400> 98
Glu Ile Asn Tyr Gly Gly Asn Thr Asn 
1               5                   


<210> 99
<211> 39
<212> PRT
<213> Homo sapiens

<400> 99
Tyr Asn Pro Ser Leu Glu Ser Arg Ile Ser Ile Ser Val Asp Thr Ser 
1               5                   10                  15      


Lys Asn Gln Val Phe Leu Arg Val Arg Phe Val Thr Ala Ala Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Ser Gly 
        35                  


<210> 100
<211> 13
<212> PRT
<213> Homo sapiens

<400> 100
Gly Arg Arg Ala Ala Val His Gly Arg Thr Phe Ala Ile 
1               5                   10              


<210> 101
<211> 11
<212> PRT
<213> Homo sapiens

<400> 101
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210> 102
<211> 23
<212> PRT
<213> Homo sapiens

<400> 102
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210> 103
<211> 16
<212> PRT
<213> Homo sapiens

<400> 103
Arg Ser Ser Gln Ser Leu Leu His Thr Asn Gly Asn Asn Tyr Leu Val 
1               5                   10                  15      


<210> 104
<211> 15
<212> PRT
<213> Homo sapiens

<400> 104
Trp Tyr Leu Gln Lys Pro Gly Gln Ala Pro His Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 105
<211> 7
<212> PRT
<213> Homo sapiens

<400> 105
Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210> 106
<211> 32
<212> PRT
<213> Homo sapiens

<400> 106
Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Val Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210> 107
<211> 9
<212> PRT
<213> Homo sapiens

<400> 107
Met Gln Ser Leu Gln Thr Pro Pro Thr 
1               5                   


<210> 108
<211> 10
<212> PRT
<213> Homo sapiens

<400> 108
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210> 109
<211> 1395
<212> DNA
<213> Homo sapiens

<400> 109
atggagtttg ggctgagctg ggttttcctt gttgccattt taaaaggtgt ccagtgtgag       60

gtgcagctgg tggagtccgg gggaggctta gttcagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac tttcagaagt tactggatgc actgggtccg ccaagttcca      180

gggaaggggc tggtgtgggt gtcatgtatt aataaagaag ggagtagcac aacctacgcg      240

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac gctgtatttg      300

gaaatgaaca gtctgagagc cgacgacacg gctgtgtatt attgtctaag gggatacgat      360

gttgactact ggggccaggg aacgctggtc accgtctcct cagcctccac caagggccca      420

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      480

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      540

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      600

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      660

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact      720

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      780

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      840

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      900

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgggtggtc      960

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1020

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1080

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1140

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1200

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1260

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1320

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1380

tctccgggta aatga                                                      1395


<210> 110
<211> 464
<212> PRT
<213> Homo sapiens

<400> 110
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Arg Ser Tyr Trp Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu 
    50                  55                  60                  


Val Trp Val Ser Cys Ile Asn Lys Glu Gly Ser Ser Thr Thr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Leu Arg Gly Tyr Asp Val Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210> 111
<211> 723
<212> DNA
<213> Homo sapiens

<400> 111
atggcctgga ctcctctcct cctcctgttc ctctctcact gcacaggttc cctctcgcag       60

gctgtgctga ctcagccgtc ctccctctct gcatctcccg gagcatcagt cagtctcacc      120

tgcaccttgc gcagtggcat caatgttggt acctacagga tatactggta tcagcagaag      180

ccagggagtc ctccccgtta tctcctgagg tacaaatcag gcttagataa acaccagggc      240

tctggagtcc ccagccgctt ctctggatcc aaagatgatt cggccaatgc agggatttta      300

ttcatttctg ggctccagtc tgaggatgag gctgattatt actgtttgat ttggcacagc      360

agcgctgtgg tattcggcgg agggaccaag ctgaccgtcc taggtcagcc caaggctgcc      420

ccctcggtca ctctgttccc gccctcctct gaggagcttc aagccaacaa ggccacacta      480

gtgtgtctga tcagtgactt ctacccggga gctgtgacag tggcttggaa ggcagatggc      540

agccccgtca aggcgggagt ggagacgacc aaaccctcca aacagagcaa caacaagtac      600

gcggccagca gctacctgag cctgacgccc gagcagtgga agtcccacag aagctacagc      660

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac agaatgttca      720

tag                                                                    723


<210> 112
<211> 240
<212> PRT
<213> Homo sapiens

<400> 112
Met Ala Trp Thr Pro Leu Leu Leu Leu Phe Leu Ser His Cys Thr Gly 
1               5                   10                  15      


Ser Leu Ser Gln Ala Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Pro Gly Ala Ser Val Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn 
        35                  40                  45              


Val Gly Thr Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro 
    50                  55                  60                  


Pro Arg Tyr Leu Leu Arg Tyr Lys Ser Gly Leu Asp Lys His Gln Gly 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Asp Ser Ala Asn 
                85                  90                  95      


Ala Gly Ile Leu Phe Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
            100                 105                 110         


Tyr Tyr Cys Leu Ile Trp His Ser Ser Ala Val Val Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
    130                 135                 140                 


Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
                165                 170                 175     


Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro 
            180                 185                 190         


Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
        195                 200                 205             


Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr 
    210                 215                 220                 


His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235                 240 


<210> 113
<211> 25
<212> PRT
<213> Homo sapiens

<400> 113
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 114
<211> 10
<212> PRT
<213> Homo sapiens

<400> 114
Gly Phe Thr Phe Arg Ser Tyr Trp Met His 
1               5                   10  


<210> 115
<211> 14
<212> PRT
<213> Homo sapiens

<400> 115
Trp Val Arg Gln Val Pro Gly Lys Gly Leu Val Trp Val Ser 
1               5                   10                  


<210> 116
<211> 10
<212> PRT
<213> Homo sapiens

<400> 116
Cys Ile Asn Lys Glu Gly Ser Ser Thr Thr 
1               5                   10  


<210> 117
<211> 39
<212> PRT
<213> Homo sapiens

<400> 117
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Glu Met Asn Ser Leu Arg Ala Asp Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Leu Arg 
        35                  


<210> 118
<211> 8
<212> PRT
<213> Homo sapiens

<400> 118
Gly Tyr Asp Val Asp Tyr Trp Gly 
1               5               


<210> 119
<211> 9
<212> PRT
<213> Homo sapiens

<400> 119
Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   


<210> 120
<211> 25
<212> PRT
<213> Homo sapiens

<400> 120
Gln Ala Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Val Ser Leu Thr Cys Thr Leu Arg 
            20                  25  


<210> 121
<211> 11
<212> PRT
<213> Homo sapiens

<400> 121
Ser Gly Ile Asn Val Gly Thr Tyr Arg Ile Tyr 
1               5                   10      


<210> 122
<211> 14
<212> PRT
<213> Homo sapiens

<400> 122
Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Arg Tyr Leu Leu 
1               5                   10                  


<210> 123
<211> 9
<212> PRT
<213> Homo sapiens

<400> 123
Arg Tyr Lys Ser Gly Leu Asp Lys His 
1               5                   


<210> 124
<211> 39
<212> PRT
<213> Homo sapiens

<400> 124
Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Asp Ser 
1               5                   10                  15      


Ala Asn Ala Gly Ile Leu Phe Ile Ser Gly Leu Gln Ser Glu Asp Glu 
            20                  25                  30          


Ala Asp Tyr Tyr Cys Leu Ile 
        35                  


<210> 125
<211> 8
<212> PRT
<213> Homo sapiens

<400> 125
Trp His Ser Ser Ala Val Val Phe 
1               5               


<210> 126
<211> 19
<212> PRT
<213> Homo sapiens

<400> 126
Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
1               5                   10                  15      


Ser Val Thr 
            


<210> 127
<211> 1413
<212> DNA
<213> Homo sapiens

<400> 127
atggagttgg ggctgtgctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggaggcttg gtacagccgg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac cttcactacc tctaccatga actgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ttcatacatt actaggacca gcactgtcat atactatgca      240

gactctgtga agggccgatt caccatctcc agagacaatg ccaagaactc actgtatctg      300

caaatgagca gcctgagagc cgaggacacg gctgtgtatt attgtgcgag aggggtgagg      360

gacattggcg gaaacggttt tgactactgg ggccagggaa ccctggtcac cgtctcctca      420

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      780

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      960

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1140

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggtaaa tga                                  1413


<210> 128
<211> 470
<212> PRT
<213> Homo sapiens

<400> 128
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Thr Ser Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Tyr Ile Thr Arg Thr Ser Thr Val Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Val Arg Asp Ile Gly Gly Asn Gly Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210> 129
<211> 711
<212> DNA
<213> Homo sapiens

<400> 129
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctctctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgtaacc agcagttact tagcctggta ccagcagaaa      180

actggccagg ctcccaggct cctcatctac ggcgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcgc cagactggag      300

cctgaagatt ttgcggtgta ttactgtcag cagtatggta gctcgcctcc gtacactttt      360

ggccagggga ccaagctgga gatcaaacga actgtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta g               711


<210> 130
<211> 236
<212> PRT
<213> Homo sapiens

<400> 130
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Thr Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Thr Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ala Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210> 131
<211> 25
<212> PRT
<213> Homo sapiens

<400> 131
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 132
<211> 10
<212> PRT
<213> Homo sapiens

<400> 132
Gly Phe Thr Phe Thr Thr Ser Thr Met Asn 
1               5                   10  


<210> 133
<211> 14
<212> PRT
<213> Homo sapiens

<400> 133
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210> 134
<211> 9
<212> PRT
<213> Homo sapiens

<400> 134
Tyr Ile Thr Arg Thr Ser Thr Val Ile 
1               5                   


<210> 135
<211> 40
<212> PRT
<213> Homo sapiens

<400> 135
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40  


<210> 136
<211> 12
<212> PRT
<213> Homo sapiens

<400> 136
Gly Val Arg Asp Ile Gly Gly Asn Gly Phe Asp Tyr 
1               5                   10          


<210> 137
<211> 11
<212> PRT
<213> Homo sapiens

<400> 137
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210> 138
<211> 23
<212> PRT
<213> Homo sapiens

<400> 138
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210> 139
<211> 11
<212> PRT
<213> Homo sapiens

<400> 139
Arg Ala Ser Gln Ser Ile Ser Ser Asn Leu Ala 
1               5                   10      


<210> 140
<211> 15
<212> PRT
<213> Homo sapiens

<400> 140
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 141
<211> 7
<212> PRT
<213> Homo sapiens

<400> 141
Asp Ala Ser Thr Arg Ala Thr 
1               5           


<210> 142
<211> 32
<212> PRT
<213> Homo sapiens

<400> 142
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210> 143
<211> 9
<212> PRT
<213> Homo sapiens

<400> 143
Gln Gln Tyr Asn Asp Trp Leu Val Thr 
1               5                   


<210> 144
<211> 10
<212> PRT
<213> Homo sapiens

<400> 144
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210> 145
<211> 1407
<212> DNA
<213> Homo sapiens

<400> 145
atggaactgg ggctccgctg ggttttcctt gttgctattt tagaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggaggcctg gtcaagcctg gggggtccct gagagtctcc      120

tgtgcagcct ctggattcac cttcagtagc tatagcatga actggatccg ccaggctcca      180

gggaaggggc tggagtgggt ctcatccatt agtagtaata gtagttacat atactacgca      240

gactcagtta agggccgatt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtttatt actgtgcgag agatcgggac      360

tacagtaact accttaccgc gtggggccag ggaaccctgg tcaccgtctc ctcagcctcc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgggtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaatga                                         1407


<210> 146
<211> 468
<212> PRT
<213> Homo sapiens

<400> 146
Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ser Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ser Ile Ser Ser Asn Ser Ser Tyr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Asp Tyr Ser Asn Tyr Leu Thr Ala Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210> 147
<211> 711
<212> DNA
<213> Homo sapiens

<400> 147
atggcctggt ctcctctcct cctcactctc ctcgctcact gcacagggtc ctgggcccag       60

tctgtgctga cgcagccgcc ctcagtgtct ggggccccag ggcagagggt caccatctcc      120

tgcactggga gcagctccaa catcggggca ggttatgatg tacactggta ccgccaactt      180

ccaggaacag cccccaaact cctcatctat ggtaagaaca atcggccctc aggggtccct      240

aaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcac tggcctccag      300

gctgaggatg aggctgatta ttactgtcag tcctatgaca gcagcctgag tggttcggta      360

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      420

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactagt gtgtctgatc      480

agtgacttct acccgggagc tgtgacagtg gcttggaagg cagatggcag ccccgtcaag      540

gcgggagtgg agacgaccaa accctccaaa cagagcaaca acaagtacgc ggccagcagc      600

tacctgagcc tgacgcccga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      660

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata g               711


<210> 148
<211> 236
<212> PRT
<213> Homo sapiens

<400> 148
Met Ala Trp Ser Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Val His Trp Tyr Arg Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Ser Ser Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210> 149
<211> 25
<212> PRT
<213> Homo sapiens

<400> 149
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser 
            20                  25  


<210> 150
<211> 10
<212> PRT
<213> Homo sapiens

<400> 150
Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   10  


<210> 151
<211> 14
<212> PRT
<213> Homo sapiens

<400> 151
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210> 152
<211> 9
<212> PRT
<213> Homo sapiens

<400> 152
Ser Ile Ser Ser Asn Ser Ser Tyr Ile 
1               5                   


<210> 153
<211> 40
<212> PRT
<213> Homo sapiens

<400> 153
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40  


<210> 154
<211> 10
<212> PRT
<213> Homo sapiens

<400> 154
Asp Arg Asp Tyr Ser Asn Tyr Leu Thr Ala 
1               5                   10  


<210> 155
<211> 11
<212> PRT
<213> Homo sapiens

<400> 155
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210> 156
<211> 22
<212> PRT
<213> Homo sapiens

<400> 156
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys 
            20          


<210> 157
<211> 14
<212> PRT
<213> Homo sapiens

<400> 157
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 158
<211> 15
<212> PRT
<213> Homo sapiens

<400> 158
Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210> 159
<211> 7
<212> PRT
<213> Homo sapiens

<400> 159
Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210> 160
<211> 32
<212> PRT
<213> Homo sapiens

<400> 160
Gly Val Pro Asn Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210> 161
<211> 11
<212> PRT
<213> Homo sapiens

<400> 161
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 
1               5                   10      


<210> 162
<211> 20
<212> PRT
<213> Homo sapiens

<400> 162
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
1               5                   10                  15      


Pro Ser Val Thr 
            20  


<210> 163
<211> 1395
<212> DNA
<213> Homo sapiens

<400> 163
atggagtttg ggctgagctg ggttttcctt gttgccattt taaaaggtgt ccagtgtgag       60

gtgcagctgg tggagtccgg gggaggctta gttcagcctg gggggtccct gagactctcc      120

tgttcagcct ctggattcac tttcagaagt tactggatgc actgggtccg ccaagttcca      180

gggaaggggc tggtatgggt ctcatgtatt aataaagaag ggagtagcac aacctacgcg      240

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac gctgtatttg      300

caaatgaaca gtctgagagc cgacgacacg gctgtgtatt actgtctaag gggatacgat      360

gttgactact ggggccaggg aaccctggtc accgtctcct cagcctccac caagggccca      420

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      480

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      540

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      600

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      660

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact      720

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      780

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      840

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      900

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgggtggtc      960

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1020

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1080

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1140

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1200

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1260

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1320

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1380

tctccgggta aatga                                                      1395


<210> 164
<211> 464
<212> PRT
<213> Homo sapiens

<400> 164
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Arg Ser Tyr Trp Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu 
    50                  55                  60                  


Val Trp Val Ser Cys Ile Asn Lys Glu Gly Ser Ser Thr Thr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Leu Arg Gly Tyr Asp Val Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210> 165
<211> 723
<212> DNA
<213> Homo sapiens

<400> 165
atggcctgga ctcctctcct cctcctgttc ctctctcact gcacaggttc cctctcgcag       60

gctgtgctga ctcagccgtc ctccctctct gcatctcccg gagcatcagt cagtctcacc      120

tgcaccttgc gcagtggcgt caatgttggt tcctacagga tatactggta tcagcagaag      180

ccagggagtc ctccccggta tctcctgagg tacaaatcag gcttagataa acaccagggc      240

tctggagtcc ccagccgctt ctctggatcc aaagatgatt cggccaatgc agggatttta      300

ttcatttctg ggctccagtc tgagaatgat gctgattatt actgtttgat ttggcacaac      360

agcgctgtgg tattcggcgg agggaccaag ctgaccgtcc taggtcagcc caaggctgcc      420

ccctcggtca ctctgttccc gccctcctct gaggagcttc aagccaacaa ggccacactg      480

gtgtgtctga tcagtgactt ctacccggga gctgtgacag tggcttggaa ggcagatggc      540

agccccgtca aggcgggagt ggagacgacc aaaccctcca aacagagcaa caacaagtac      600

gcggccagca gctacctgag cctgacgccc gagcagtgga agtcccacag aagctacagc      660

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac agaatgttca      720

tag                                                                    723


<210> 166
<211> 240
<212> PRT
<213> Homo sapiens

<400> 166
Met Ala Trp Thr Pro Leu Leu Leu Leu Phe Leu Ser His Cys Thr Gly 
1               5                   10                  15      


Ser Leu Ser Gln Ala Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Pro Gly Ala Ser Val Ser Leu Thr Cys Thr Leu Arg Ser Gly Val Asn 
        35                  40                  45              


Val Gly Ser Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro 
    50                  55                  60                  


Pro Arg Tyr Leu Leu Arg Tyr Lys Ser Gly Leu Asp Lys His Gln Gly 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Asp Ser Ala Asn 
                85                  90                  95      


Ala Gly Ile Leu Phe Ile Ser Gly Leu Gln Ser Glu Asn Asp Ala Asp 
            100                 105                 110         


Tyr Tyr Cys Leu Ile Trp His Asn Ser Ala Val Val Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
    130                 135                 140                 


Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
                165                 170                 175     


Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro 
            180                 185                 190         


Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
        195                 200                 205             


Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr 
    210                 215                 220                 


His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235                 240 


<210> 167
<211> 25
<212> PRT
<213> Homo sapiens

<400> 167
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


<210> 168
<211> 10
<212> PRT
<213> Homo sapiens

<400> 168
Gly Phe Thr Phe Arg Ser Tyr Trp Met His 
1               5                   10  


<210> 169
<211> 14
<212> PRT
<213> Homo sapiens

<400> 169
Trp Val Arg Gln Val Pro Gly Lys Gly Leu Val Trp Val Ser 
1               5                   10                  


<210> 170
<211> 10
<212> PRT
<213> Homo sapiens

<400> 170
Cys Ile Asn Lys Glu Gly Ser Ser Thr Thr 
1               5                   10  


<210> 171
<211> 39
<212> PRT
<213> Homo sapiens

<400> 171
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Leu Arg 
        35                  


<210> 172
<211> 8
<212> PRT
<213> Homo sapiens

<400> 172
Gly Tyr Asp Val Asp Tyr Trp Gly 
1               5               


<210> 173
<211> 9
<212> PRT
<213> Homo sapiens

<400> 173
Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   


<210> 174
<211> 25
<212> PRT
<213> Homo sapiens

<400> 174
Gln Ala Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Val Ser Leu Thr Cys Thr Leu Arg 
            20                  25  


<210> 175
<211> 11
<212> PRT
<213> Homo sapiens

<400> 175
Ser Gly Val Asn Val Gly Ser Tyr Arg Ile Tyr 
1               5                   10      


<210> 176
<211> 14
<212> PRT
<213> Homo sapiens

<400> 176
Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Arg Tyr Leu Leu 
1               5                   10                  


<210> 177
<211> 9
<212> PRT
<213> Homo sapiens

<400> 177
Arg Tyr Lys Ser Gly Leu Asp Lys His 
1               5                   


<210> 178
<211> 39
<212> PRT
<213> Homo sapiens

<400> 178
Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Asp Ser 
1               5                   10                  15      


Ala Asn Ala Gly Ile Leu Phe Ile Ser Gly Leu Gln Ser Glu Asn Asp 
            20                  25                  30          


Ala Asp Tyr Tyr Cys Leu Ile 
        35                  


<210> 179
<211> 8
<212> PRT
<213> Homo sapiens

<400> 179
Trp His Asn Ser Ala Val Val Phe 
1               5               


<210> 180
<211> 19
<212> PRT
<213> Homo sapiens

<400> 180
Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
1               5                   10                  15      


Ser Val Thr 
            


<210> 181
<211> 1416
<212> DNA
<213> Homo sapiens

<400> 181
atgaaacacc tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtctcag       60

gtgcatctgc aggagtcggg cccaggactg gtgaagcctt cggggaccct gtccctcacc      120

tgcgctgtct ctggtggctc catcagttac actaactggt ggagttgggt ccgcctgccc      180

ccagggaagg ggctggagtg gataggggaa atctatcata gtaggagcac caactacaac      240

ccgtccctca agagtcgagt caccatgtca atagacaagt ccaagaatct gttctccctg      300

aagctgaact ctgtgaccgc cgcggacacg gccatctatt actgtgctaa agccgcttac      360

acaagggatg gaatacagcc ttttgacaac tggggccagg gaaccctggt caccgtctcc      420

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210> 182
<211> 471
<212> PRT
<213> Homo sapiens

<400> 182
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Tyr Thr Asn Trp Trp Ser Trp Val Arg Leu Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Arg Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Met Ser Ile Asp Lys Ser Lys Asn 
                85                  90                  95      


Leu Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Ala Ala Tyr Thr Arg Asp Gly Ile Gln Pro Phe 
        115                 120                 125             


Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210> 183
<211> 723
<212> DNA
<213> Homo sapiens

<400> 183
atggtgttgc agacccaggt cttcatttct ctgttgctct ggatctctgg tgcctacggg       60

gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc      120

atcaactgca agtccagcca gagtgtttta aagagctcca acaataagaa ctacttagct      180

tggtaccagc agaaaccagg acagcctcct aagctgctca ttttctgggc atcgacccgg      240

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      300

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttctagtgct      360

cctcgaactt tcggcggagg gaccaacgta gaaatcagac gaactgtggc tgcaccatct      420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      720

tag                                                                    723


<210> 184
<211> 240
<212> PRT
<213> Homo sapiens

<400> 184
Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Lys Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Ser Ser Ala Pro Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Asn Val Glu Ile Arg Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210> 185
<211> 25
<212> PRT
<213> Homo sapiens

<400> 185
Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser 
            20                  25  


<210> 186
<211> 11
<212> PRT
<213> Homo sapiens

<400> 186
Gly Gly Ser Ile Ser Tyr Thr Asn Trp Trp Ser 
1               5                   10      


<210> 187
<211> 14
<212> PRT
<213> Homo sapiens

<400> 187
Trp Val Arg Leu Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210> 188
<211> 9
<212> PRT
<213> Homo sapiens

<400> 188
Glu Ile Tyr His Ser Arg Ser Thr Asn 
1               5                   


<210> 189
<211> 39
<212> PRT
<213> Homo sapiens

<400> 189
Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Ile Asp Lys Ser 
1               5                   10                  15      


Lys Asn Leu Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr 
            20                  25                  30          


Ala Ile Tyr Tyr Cys Ala Lys 
        35                  


<210> 190
<211> 13
<212> PRT
<213> Homo sapiens

<400> 190
Ala Ala Tyr Thr Arg Asp Gly Ile Gln Pro Phe Asp Asn 
1               5                   10              


<210> 191
<211> 11
<212> PRT
<213> Homo sapiens

<400> 191
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210> 192
<211> 23
<212> PRT
<213> Homo sapiens

<400> 192
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210> 193
<211> 17
<212> PRT
<213> Homo sapiens

<400> 193
Lys Ser Ser Gln Ser Val Leu Lys Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 194
<211> 15
<212> PRT
<213> Homo sapiens

<400> 194
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe 
1               5                   10                  15  


<210> 195
<211> 7
<212> PRT
<213> Homo sapiens

<400> 195
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 196
<211> 32
<212> PRT
<213> Homo sapiens

<400> 196
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210> 197
<211> 9
<212> PRT
<213> Homo sapiens

<400> 197
Gln Gln Tyr Ser Ser Ala Pro Arg Thr 
1               5                   


<210> 198
<211> 10
<212> PRT
<213> Homo sapiens

<400> 198
Phe Gly Gly Gly Thr Asn Val Glu Ile Arg 
1               5                   10  


<210> 199
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 199
Ser Gly Ser Gly His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr 
1               5                   10                  15      


Tyr Tyr Asp Glu Asp Ser Lys Leu 
            20                  


<210> 200
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 200
Ser Gly Ser Gly Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asp Ile Asn Thr Gly Ala 
            20                  


<210> 201
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 201
Ser Gly Ser Gly Leu Thr Ser Tyr Lys Ile Ile Asn Gly Lys His Phe 
1               5                   10                  15      


Tyr Phe Asn Asn Asp Gly Val Met 
            20                  


<210> 202
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 202
Ser Gly Ser Gly Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asp Asn Asn Ser Lys Ala 
            20                  


<210> 203
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 203
Ser Gly Ser Gly Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Pro Asn Asn Ala Ile 
            20                  


<210> 204
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 204
Ser Gly Ser Gly Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Pro Asp Thr Ala Ile 
            20                  


<210> 205
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 205
Ser Gly Ser Gly Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr 
1               5                   10                  15      


Tyr Phe Asp Thr Asp Thr Ala Ile 
            20                  


<210> 206
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 206
Ser Gly Ser Gly Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe 
1               5                   10                  15      


Tyr Phe Asp Ser Asp Cys Val Val 
            20                  


<210> 207
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 207
Ser Gly Ser Gly Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Thr Asn Thr Ala Glu 
            20                  


<210> 208
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 208
Ser Gly Ser Gly Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Thr Asn Thr Ala Glu 
            20                  


<210> 209
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 209
Ser Gly Ser Gly Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Thr Asn Thr Ala Ile 
            20                  


<210> 210
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 210
Ser Gly Ser Gly Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe 
1               5                   10                  15      


Tyr Phe Asn Thr Asp Gly Ile Met 
            20                  


<210> 211
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 211
Ser Gly Ser Gly Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Gly Ser Asp Ser Lys Ala 
            20                  


<210> 212
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 212
Ser Gly Ser Gly Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Pro Asn Asn Ala Ile 
            20                  


<210> 213
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 213
Ser Gly Ser Gly Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr 
1               5                   10                  15      


Tyr Phe Ser Tyr Asp Gly Ile Leu 
            20                  


<210> 214
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 214
Ser Gly Ser Gly Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe 
1               5                   10                  15      


Tyr Phe Asp Ala Asn Asn Glu Ser 
            20                  


<210> 215
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 215
Ser Gly Ser Gly Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asp Asn Asp Ser Lys Ala 
            20                  


<210> 216
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 216
Ser Gly Ser Gly Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Leu Asn Thr Ala Glu 
            20                  


<210> 217
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 217
Ser Gly Ser Gly Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Leu Asn Thr Ala Glu 
            20                  


<210> 218
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 218
Ser Gly Ser Gly Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Thr Asn Thr Phe Ile 
            20                  


<210> 219
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 219
Ser Gly Ser Gly Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe 
1               5                   10                  15      


Tyr Phe Asn Thr Asp Gly Ile Met 
            20                  


<210> 220
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 220
Ser Gly Ser Gly Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Gly Ser Asp Ser Lys Ala 
            20                  


<210> 221
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 221
Ser Gly Ser Gly Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Thr Asn Thr Ala Val 
            20                  


<210> 222
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 222
Ser Gly Ser Gly Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr 
1               5                   10                  15      


Tyr Phe Asn Thr Asn Thr Ser Ile 
            20                  


<210> 223
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 223
Ser Gly Ser Gly Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe 
1               5                   10                  15      


Tyr Phe Asn Thr Asp Gly Ile Met 
            20                  


<210> 224
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 224
Ser Gly Ser Gly Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr 
1               5                   10                  15      


Tyr Phe Gly Asn Asn Ser Lys Ala 
            20                  


<210> 225
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 225
Ser Gly Ser Gly Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr 
1               5                   10                  15      


Tyr Phe Glu Pro Asn Thr Ala Met 
            20                  


<210> 226
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 226
Ser Gly Ser Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe 
1               5                   10                  15      


Tyr Phe Arg Asn Gly Leu Pro Gln 
            20                  


<210> 227
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 227
Ser Gly Ser Gly Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr 
1               5                   10                  15      


Tyr Phe Gly Asn Asn Ser Lys Ala 
            20                  


<210> 228
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 228
Ser Gly Ser Gly Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
1               5                   10                  15      


Tyr Phe Met Pro Asp Thr Ala Met 
            20                  


<210> 229
<211> 24
<212> PRT
<213> Clostridium difficile

<400> 229
Ser Gly Ser Gly Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr 
1               5                   10                  15      


Phe Phe Gly Val Asp Gly Val Lys 
            20                  


<210> 230
<211> 2710
<212> PRT
<213> Clostridium difficile

<400> 230
Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      


Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          


Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              


Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr 
    50                  55                  60                  


Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  


Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      


Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         


Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             


Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 


Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 


Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     


Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         


Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             


Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg 
    210                 215                 220                 


Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 


Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     


Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         


Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met 
        275                 280                 285             


Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser 
    290                 295                 300                 


Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 


Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     


Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         


Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             


Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 


Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 


Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     


Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         


Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             


Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 


Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 


Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     


Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         


Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             


Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu 
    530                 535                 540                 


Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr 
545                 550                 555                 560 


Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser 
                565                 570                 575     


Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser 
            580                 585                 590         


Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile 
        595                 600                 605             


Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser 
    610                 615                 620                 


Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu 
625                 630                 635                 640 


Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly 
                645                 650                 655     


Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser 
            660                 665                 670         


Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile 
        675                 680                 685             


Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser 
    690                 695                 700                 


Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser 
705                 710                 715                 720 


Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser 
                725                 730                 735     


Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
            740                 745                 750         


Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu 
        755                 760                 765             


Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser 
    770                 775                 780                 


Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala 
785                 790                 795                 800 


Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser 
                805                 810                 815     


Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser 
            820                 825                 830         


Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn 
        835                 840                 845             


Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu 
    850                 855                 860                 


Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu 
865                 870                 875                 880 


Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser 
                885                 890                 895     


Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr 
            900                 905                 910         


Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr 
        915                 920                 925             


Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly 
    930                 935                 940                 


Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr 
945                 950                 955                 960 


Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn 
                965                 970                 975     


Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr 
            980                 985                 990         


Ala Gln Leu Phe Ser Thr Gly Leu  Asn Thr Ile Tyr Asp  Ser Ile Gln 
        995                 1000                 1005             


Leu Val  Asn Leu Ile Ser Asn  Ala Val Asn Asp Thr  Ile Asn Val 
    1010                 1015                 1020             


Leu Pro  Thr Ile Thr Glu Gly  Ile Pro Ile Val Ser  Thr Ile Leu 
    1025                 1030                 1035             


Asp Gly  Ile Asn Leu Gly Ala  Ala Ile Lys Glu Leu  Leu Asp Glu 
    1040                 1045                 1050             


His Asp  Pro Leu Leu Lys Lys  Glu Leu Glu Ala Lys  Val Gly Val 
    1055                 1060                 1065             


Leu Ala  Ile Asn Met Ser Leu  Ser Ile Ala Ala Thr  Val Ala Ser 
    1070                 1075                 1080             


Ile Val  Gly Ile Gly Ala Glu  Val Thr Ile Phe Leu  Leu Pro Ile 
    1085                 1090                 1095             


Ala Gly  Ile Ser Ala Gly Ile  Pro Ser Leu Val Asn  Asn Glu Leu 
    1100                 1105                 1110             


Ile Leu  His Asp Lys Ala Thr  Ser Val Val Asn Tyr  Phe Asn His 
    1115                 1120                 1125             


Leu Ser  Glu Ser Lys Lys Tyr  Gly Pro Leu Lys Thr  Glu Asp Asp 
    1130                 1135                 1140             


Lys Ile  Leu Val Pro Ile Asp  Asp Leu Val Ile Ser  Glu Ile Asp 
    1145                 1150                 1155             


Phe Asn  Asn Asn Ser Ile Lys  Leu Gly Thr Cys Asn  Ile Leu Ala 
    1160                 1165                 1170             


Met Glu  Gly Gly Ser Gly His  Thr Val Thr Gly Asn  Ile Asp His 
    1175                 1180                 1185             


Phe Phe  Ser Ser Pro Ser Ile  Ser Ser His Ile Pro  Ser Leu Ser 
    1190                 1195                 1200             


Ile Tyr  Ser Ala Ile Gly Ile  Glu Thr Glu Asn Leu  Asp Phe Ser 
    1205                 1210                 1215             


Lys Lys  Ile Met Met Leu Pro  Asn Ala Pro Ser Arg  Val Phe Trp 
    1220                 1225                 1230             


Trp Glu  Thr Gly Ala Val Pro  Gly Leu Arg Ser Leu  Glu Asn Asp 
    1235                 1240                 1245             


Gly Thr  Arg Leu Leu Asp Ser  Ile Arg Asp Leu Tyr  Pro Gly Lys 
    1250                 1255                 1260             


Phe Tyr  Trp Arg Phe Tyr Ala  Phe Phe Asp Tyr Ala  Ile Thr Thr 
    1265                 1270                 1275             


Leu Lys  Pro Val Tyr Glu Asp  Thr Asn Ile Lys Ile  Lys Leu Asp 
    1280                 1285                 1290             


Lys Asp  Thr Arg Asn Phe Ile  Met Pro Thr Ile Thr  Thr Asn Glu 
    1295                 1300                 1305             


Ile Arg  Asn Lys Leu Ser Tyr  Ser Phe Asp Gly Ala  Gly Gly Thr 
    1310                 1315                 1320             


Tyr Ser  Leu Leu Leu Ser Ser  Tyr Pro Ile Ser Thr  Asn Ile Asn 
    1325                 1330                 1335             


Leu Ser  Lys Asp Asp Leu Trp  Ile Phe Asn Ile Asp  Asn Glu Val 
    1340                 1345                 1350             


Arg Glu  Ile Ser Ile Glu Asn  Gly Thr Ile Lys Lys  Gly Lys Leu 
    1355                 1360                 1365             


Ile Lys  Asp Val Leu Ser Lys  Ile Asp Ile Asn Lys  Asn Lys Leu 
    1370                 1375                 1380             


Ile Ile  Gly Asn Gln Thr Ile  Asp Phe Ser Gly Asp  Ile Asp Asn 
    1385                 1390                 1395             


Lys Asp  Arg Tyr Ile Phe Leu  Thr Cys Glu Leu Asp  Asp Lys Ile 
    1400                 1405                 1410             


Ser Leu  Ile Ile Glu Ile Asn  Leu Val Ala Lys Ser  Tyr Ser Leu 
    1415                 1420                 1425             


Leu Leu  Ser Gly Asp Lys Asn  Tyr Leu Ile Ser Asn  Leu Ser Asn 
    1430                 1435                 1440             


Thr Ile  Glu Lys Ile Asn Thr  Leu Gly Leu Asp Ser  Lys Asn Ile 
    1445                 1450                 1455             


Ala Tyr  Asn Tyr Thr Asp Glu  Ser Asn Asn Lys Tyr  Phe Gly Ala 
    1460                 1465                 1470             


Ile Ser  Lys Thr Ser Gln Lys  Ser Ile Ile His Tyr  Lys Lys Asp 
    1475                 1480                 1485             


Ser Lys  Asn Ile Leu Glu Phe  Tyr Asn Asp Ser Thr  Leu Glu Phe 
    1490                 1495                 1500             


Asn Ser  Lys Asp Phe Ile Ala  Glu Asp Ile Asn Val  Phe Met Lys 
    1505                 1510                 1515             


Asp Asp  Ile Asn Thr Ile Thr  Gly Lys Tyr Tyr Val  Asp Asn Asn 
    1520                 1525                 1530             


Thr Asp  Lys Ser Ile Asp Phe  Ser Ile Ser Leu Val  Ser Lys Asn 
    1535                 1540                 1545             


Gln Val  Lys Val Asn Gly Leu  Tyr Leu Asn Glu Ser  Val Tyr Ser 
    1550                 1555                 1560             


Ser Tyr  Leu Asp Phe Val Lys  Asn Ser Asp Gly His  His Asn Thr 
    1565                 1570                 1575             


Ser Asn  Phe Met Asn Leu Phe  Leu Asp Asn Ile Ser  Phe Trp Lys 
    1580                 1585                 1590             


Leu Phe  Gly Phe Glu Asn Ile  Asn Phe Val Ile Asp  Lys Tyr Phe 
    1595                 1600                 1605             


Thr Leu  Val Gly Lys Thr Asn  Leu Gly Tyr Val Glu  Phe Ile Cys 
    1610                 1615                 1620             


Asp Asn  Asn Lys Asn Ile Asp  Ile Tyr Phe Gly Glu  Trp Lys Thr 
    1625                 1630                 1635             


Ser Ser  Ser Lys Ser Thr Ile  Phe Ser Gly Asn Gly  Arg Asn Val 
    1640                 1645                 1650             


Val Val  Glu Pro Ile Tyr Asn  Pro Asp Thr Gly Glu  Asp Ile Ser 
    1655                 1660                 1665             


Thr Ser  Leu Asp Phe Ser Tyr  Glu Pro Leu Tyr Gly  Ile Asp Arg 
    1670                 1675                 1680             


Tyr Ile  Asn Lys Val Leu Ile  Ala Pro Asp Leu Tyr  Thr Ser Leu 
    1685                 1690                 1695             


Ile Asn  Ile Asn Thr Asn Tyr  Tyr Ser Asn Glu Tyr  Tyr Pro Glu 
    1700                 1705                 1710             


Ile Ile  Val Leu Asn Pro Asn  Thr Phe His Lys Lys  Val Asn Ile 
    1715                 1720                 1725             


Asn Leu  Asp Ser Ser Ser Phe  Glu Tyr Lys Trp Ser  Thr Glu Gly 
    1730                 1735                 1740             


Ser Asp  Phe Ile Leu Val Arg  Tyr Leu Glu Glu Ser  Asn Lys Lys 
    1745                 1750                 1755             


Ile Leu  Gln Lys Ile Arg Ile  Lys Gly Ile Leu Ser  Asn Thr Gln 
    1760                 1765                 1770             


Ser Phe  Asn Lys Met Ser Ile  Asp Phe Lys Asp Ile  Lys Lys Leu 
    1775                 1780                 1785             


Ser Leu  Gly Tyr Ile Met Ser  Asn Phe Lys Ser Phe  Asn Ser Glu 
    1790                 1795                 1800             


Asn Glu  Leu Asp Arg Asp His  Leu Gly Phe Lys Ile  Ile Asp Asn 
    1805                 1810                 1815             


Lys Thr  Tyr Tyr Tyr Asp Glu  Asp Ser Lys Leu Val  Lys Gly Leu 
    1820                 1825                 1830             


Ile Asn  Ile Asn Asn Ser Leu  Phe Tyr Phe Asp Pro  Ile Glu Phe 
    1835                 1840                 1845             


Asn Leu  Val Thr Gly Trp Gln  Thr Ile Asn Gly Lys  Lys Tyr Tyr 
    1850                 1855                 1860             


Phe Asp  Ile Asn Thr Gly Ala  Ala Leu Thr Ser Tyr  Lys Ile Ile 
    1865                 1870                 1875             


Asn Gly  Lys His Phe Tyr Phe  Asn Asn Asp Gly Val  Met Gln Leu 
    1880                 1885                 1890             


Gly Val  Phe Lys Gly Pro Asp  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1895                 1900                 1905             


Asn Thr  Gln Asn Asn Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln 
    1910                 1915                 1920             


Ser Lys  Phe Leu Thr Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn 
    1925                 1930                 1935             


Asn Ser  Lys Ala Val Thr Gly  Trp Arg Ile Ile Asn  Asn Glu Lys 
    1940                 1945                 1950             


Tyr Tyr  Phe Asn Pro Asn Asn  Ala Ile Ala Ala Val  Gly Leu Gln 
    1955                 1960                 1965             


Val Ile  Asp Asn Asn Lys Tyr  Tyr Phe Asn Pro Asp  Thr Ala Ile 
    1970                 1975                 1980             


Ile Ser  Lys Gly Trp Gln Thr  Val Asn Gly Ser Arg  Tyr Tyr Phe 
    1985                 1990                 1995             


Asp Thr  Asp Thr Ala Ile Ala  Phe Asn Gly Tyr Lys  Thr Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Asp  Ser Asp Cys Val Val  Lys Ile Gly 
    2015                 2020                 2025             


Val Phe  Ser Thr Ser Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    2030                 2035                 2040             


Thr Tyr  Asn Asn Asn Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Ser 
    2045                 2050                 2055             


Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asn 
    2060                 2065                 2070             


Ser Lys  Ala Val Thr Gly Leu  Gln Thr Ile Asp Ser  Lys Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asn Thr Asn Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr 
    2090                 2095                 2100             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Glu Ala 
    2105                 2110                 2115             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    2120                 2125                 2130             


Thr Asn  Thr Ala Ile Ala Ser  Thr Gly Tyr Thr Ile  Ile Asn Gly 
    2135                 2140                 2145             


Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val 
    2150                 2155                 2160             


Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    2165                 2170                 2175             


Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Glu 
    2180                 2185                 2190             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser 
    2195                 2200                 2205             


Lys Ala  Val Thr Gly Trp Arg  Ile Ile Asn Asn Lys  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Asn Asn Ala Ile  Ala Ala Ile His Leu  Cys Thr Ile 
    2225                 2230                 2235             


Asn Asn  Asp Lys Tyr Tyr Phe  Ser Tyr Asp Gly Ile  Leu Gln Asn 
    2240                 2245                 2250             


Gly Tyr  Ile Thr Ile Glu Arg  Asn Asn Phe Tyr Phe  Asp Ala Asn 
    2255                 2260                 2265             


Asn Glu  Ser Lys Met Val Thr  Gly Val Phe Lys Gly  Pro Asn Gly 
    2270                 2275                 2280             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu 
    2285                 2290                 2295             


Gly Gln  Ala Ile Val Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly 
    2300                 2305                 2310             


Lys Lys  Tyr Tyr Phe Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp 
    2315                 2320                 2325             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala 
    2330                 2335                 2340             


Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    2345                 2350                 2355             


Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    2360                 2365                 2370             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Phe  Ile Ala Ser 
    2375                 2380                 2385             


Thr Gly  Tyr Thr Ser Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr 
    2390                 2395                 2400             


Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys Gly Pro  Asn Gly Phe 
    2405                 2410                 2415             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly 
    2420                 2425                 2430             


Gln Ala  Ile Leu Tyr Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys 
    2435                 2440                 2445             


Lys Tyr  Tyr Phe Gly Ser Asp  Ser Lys Ala Val Thr  Gly Leu Arg 
    2450                 2455                 2460             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Val 
    2465                 2470                 2475             


Ala Val  Thr Gly Trp Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe 
    2480                 2485                 2490             


Asn Thr  Asn Thr Ser Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Ser 
    2495                 2500                 2505             


Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly 
    2510                 2515                 2520             


Val Phe  Lys Gly Pro Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    2525                 2530                 2535             


Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn 
    2540                 2545                 2550             


Arg Phe  Leu Tyr Leu His Asp  Asn Ile Tyr Tyr Phe  Gly Asn Asn 
    2555                 2560                 2565             


Ser Lys  Ala Ala Thr Gly Trp  Val Thr Ile Asp Gly  Asn Arg Tyr 
    2570                 2575                 2580             


Tyr Phe  Glu Pro Asn Thr Ala  Met Gly Ala Asn Gly  Tyr Lys Thr 
    2585                 2590                 2595             


Ile Asp  Asn Lys Asn Phe Tyr  Phe Arg Asn Gly Leu  Pro Gln Ile 
    2600                 2605                 2610             


Gly Val  Phe Lys Gly Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    2615                 2620                 2625             


Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln 
    2630                 2635                 2640             


Asn Arg  Phe Leu His Leu Leu  Gly Lys Ile Tyr Tyr  Phe Gly Asn 
    2645                 2650                 2655             


Asn Ser  Lys Ala Val Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Val 
    2660                 2665                 2670             


Tyr Tyr  Phe Met Pro Asp Thr  Ala Met Ala Ala Ala  Gly Gly Leu 
    2675                 2680                 2685             


Phe Glu  Ile Asp Gly Val Ile  Tyr Phe Phe Gly Val  Asp Gly Val 
    2690                 2695                 2700             


Lys Ala  Pro Gly Ile Tyr Gly  
    2705                 2710 


<210> 231
<211> 2366
<212> PRT
<213> Clostridium difficile

<400> 231
Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys 
    1715                 1720                 1725             


Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp 
    1760                 1765                 1770             


Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1940                 1945                 1950             


Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu 
    2090                 2095                 2100             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln 
    2105                 2110                 2115             


Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn 
    2255                 2260                 2265             


Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu 
    2360                 2365     


<210> 232
<211> 7
<212> PRT
<213> Clostridium difficile


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala or Val

<400> 232
Xaa Thr Gly Trp Gln Thr Ile 
1               5           


<210> 233
<211> 14
<212> PRT
<213> Clostridium difficile


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ala or Val

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Asn or Asp

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Lys or Val

<400> 233
Xaa Thr Gly Trp Gln Thr Ile Xaa Gly Lys Xaa Tyr Tyr Phe 
1               5                   10                  


<210> 234
<211> 5
<212> PRT
<213> Clostridium difficile

<400> 234
Ser Gly Arg Asn Lys 
1               5   


<210> 235
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 235
caccatggga tttaaaataa tagataataa aacttattac                             40


<210> 236
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 236
gccatatatc ccaggggc                                                     18


<210> 237
<211> 932
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 237
Met Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp Glu Asp 
1               5                   10                  15      


Ser Lys Leu Val Lys Gly Leu Ile Asn Ile Asn Asn Ser Leu Phe Tyr 
            20                  25                  30          


Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr Ile Asn 
        35                  40                  45              


Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser 
    50                  55                  60                  


Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val 
65                  70                  75                  80  


Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala 
                85                  90                  95      


Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr 
            100                 105                 110         


Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn 
        115                 120                 125             


Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr 
    130                 135                 140                 


Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys 
                165                 170                 175     


Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr 
            180                 185                 190         


Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr 
        195                 200                 205             


Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn 
    210                 215                 220                 


Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu 
225                 230                 235                 240 


Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys 
                245                 250                 255     


Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Leu Gln Thr 
            260                 265                 270         


Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala 
        275                 280                 285             


Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
    290                 295                 300                 


Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
305                 310                 315                 320 


Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile 
                325                 330                 335     


Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly 
            340                 345                 350         


Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr 
        355                 360                 365             


Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe 
    370                 375                 380                 


Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala 
385                 390                 395                 400 


Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro 
                405                 410                 415     


Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys 
            420                 425                 430         


Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile 
        435                 440                 445             


Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val 
    450                 455                 460                 


Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
465                 470                 475                 480 


Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn 
                485                 490                 495     


Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser 
            500                 505                 510         


Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe 
        515                 520                 525             


Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
    530                 535                 540                 


Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp 
545                 550                 555                 560 


Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile 
                565                 570                 575     


Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
            580                 585                 590         


Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
        595                 600                 605             


Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln 
    610                 615                 620                 


Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
625                 630                 635                 640 


Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
                645                 650                 655     


Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
            660                 665                 670         


Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
        675                 680                 685             


Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
    690                 695                 700                 


Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
705                 710                 715                 720 


Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
                725                 730                 735     


Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
            740                 745                 750         


Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
        755                 760                 765             


Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
    770                 775                 780                 


Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
785                 790                 795                 800 


Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
                805                 810                 815     


Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
            820                 825                 830         


Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
        835                 840                 845             


Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
    850                 855                 860                 


Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
865                 870                 875                 880 


Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
                885                 890                 895     


Gly Ile Tyr Gly Lys Gly Glu Leu Asn Ser Lys Leu Glu Gly Lys Pro 
            900                 905                 910         


Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His 
        915                 920                 925             


His His His His 
    930         


<210> 238
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 238
cggatccgaa ttcattctta tgtcaactag tgaagaaaat aagg                        44


<210> 239
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 239
gtggtggtgc tcgagagctg tatcaggatc aaaataatac                             40


<210> 240
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 240
Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe 
1               5                   10                  15      


Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn 
            20                  25                  30          


Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe 
        35                  40                  45              


Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu 
    50                  55                  60                  


Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met 
65                  70                  75                  80  


Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro 
                85                  90                  95      


Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys 
            100                 105                 110         


Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr 
        115                 120                 125             


Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln 
    130                 135                 140                 


Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala 
145                 150                 155                 160 


Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly 
                165                 170                 175     


Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg 
            180                 185                 190         


Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser 
        195                 200                 205             


Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr 
    210                 215                 220                 


Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser 
225                 230                 235                 240 


Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val Met Lys Val 
                245                 250                 255     


Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly 
            260                 265                 270         


Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe 
        275                 280                 285             


Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser 
    290                 295                 300                 


Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp 
305                 310                 315                 320 


Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys 
                325                 330                 335     


Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu 
            340                 345                 350         


Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val 
        355                 360                 365             


Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly 
    370                 375                 380                 


Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile 
385                 390                 395                 400 


Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly 
                405                 410                 415     


Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly 
            420                 425                 430         


Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr 
        435                 440                 445             


Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met 
    450                 455                 460                 


Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala 
465                 470                 475                 480 


Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu 
                485                 490                 495     


Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr 
            500                 505                 510         


Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu 
        515                 520                 525             


Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val 
    530                 535                 540                 


Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu 
545                 550                 555                 560 


Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp 
                565                 570                 575     


Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr 
            580                 585                 590         


Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr 
        595                 600                 605             


Ala Leu Glu His His His His His His 
    610                 615         


<210> 241
<211> 20
<212> PRT
<213> Clostridium difficile

<400> 241
Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile 
1               5                   10                  15      


Asn Thr Gly Ala 
            20  


<210> 242
<211> 20
<212> PRT
<213> Clostridium difficile

<400> 242
Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu 
1               5                   10                  15      


Asn Thr Ala Glu 
            20  


<210> 243
<211> 20
<212> PRT
<213> Clostridium difficile

<400> 243
Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro 
1               5                   10                  15      


Asp Thr Ala Met 
            20  


<210> 244
<211> 15
<212> PRT
<213> Clostridium difficile

<400> 244
Thr Asp Ile Cys Ile Asp Thr Tyr Lys Lys Ser Gly Arg Asn Lys 
1               5                   10                  15  


<210> 245
<211> 15
<212> PRT
<213> Clostridium difficile

<400> 245
Asp Thr Tyr Lys Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe 
1               5                   10                  15  


<210> 246
<211> 15
<212> PRT
<213> Clostridium difficile

<400> 246
Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
1               5                   10                  15  


<210> 247
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 247
Ser Gly Ser Gly Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met 
1               5                   10                  15      


Ala Asn Val 
            


<210> 248
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 248
Ser Gly Ser Gly Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe 
1               5                   10                  15      


Arg Thr Gln 
            


<210> 249
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 249
Ser Gly Ser Gly Lys Met Ala Asn Val Arg Phe Arg Thr Gln Glu Asp 
1               5                   10                  15      


Glu Tyr Val 
            


<210> 250
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 250
Ser Gly Ser Gly Arg Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile 
1               5                   10                  15      


Leu Asp Ala 
            


<210> 251
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 251
Ser Gly Ser Gly Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
1               5                   10                  15      


Glu Tyr His 
            


<210> 252
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 252
Ser Gly Ser Gly Ala Ile Leu Asp Ala Leu Glu Glu Tyr His Asn Met 
1               5                   10                  15      


Ser Glu Asn 
            


<210> 253
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 253
Ser Gly Ser Gly Leu Glu Glu Tyr His Asn Met Ser Glu Asn Thr Val 
1               5                   10                  15      


Val Glu Lys 
            


<210> 254
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 254
Ser Gly Ser Gly Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu 
1               5                   10                  15      


Lys Leu Lys 
            


<210> 255
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 255
Ser Gly Ser Gly Thr Val Val Glu Lys Tyr Leu Lys Leu Lys Asp Ile 
1               5                   10                  15      


Asn Ser Leu 
            


<210> 256
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 256
Ser Gly Ser Gly Tyr Leu Lys Leu Lys Asp Ile Asn Ser Leu Thr Asp 
1               5                   10                  15      


Ile Cys Ile 
            


<210> 257
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 257
Ser Gly Ser Gly Asp Ile Asn Ser Leu Thr Asp Ile Cys Ile Asp Thr 
1               5                   10                  15      


Tyr Lys Lys 
            


<210> 258
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 258
Ser Gly Ser Gly Thr Asp Ile Cys Ile Asp Thr Tyr Lys Lys Ser Gly 
1               5                   10                  15      


Arg Asn Lys 
            


<210> 259
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 259
Ser Gly Ser Gly Asp Thr Tyr Lys Lys Ser Gly Arg Asn Lys Ala Leu 
1               5                   10                  15      


Lys Lys Phe 
            


<210> 260
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 260
Ser Gly Ser Gly Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu 
1               5                   10                  15      


Tyr Leu Val 
            


<210> 261
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 261
Ser Gly Ser Gly Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr Glu 
1               5                   10                  15      


Val Leu Glu 
            


<210> 262
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 262
Ser Gly Ser Gly Lys Glu Tyr Leu Val Thr Glu Val Leu Glu Leu Lys 
1               5                   10                  15      


Asn Asn Asn 
            


<210> 263
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 263
Ser Gly Ser Gly Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr 
1               5                   10                  15      


Pro Val Glu 
            


<210> 264
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 264
Ser Gly Ser Gly Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn 
1               5                   10                  15      


Leu His Phe 
            


<210> 265
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 265
Ser Gly Ser Gly Lys Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile 
1               5                   10                  15      


Asn Asp Thr 
            


<210> 266
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 266
Ser Gly Ser Gly Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
1               5                   10                  15      


Asn Tyr Ile 
            


<210> 267
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 267
Ser Gly Ser Gly Gln Ile Asn Asp Thr Ala Ile Asn Tyr Ile Asn Gln 
1               5                   10                  15      


Trp Lys Asp 
            


<210> 268
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 268
Ser Gly Ser Gly Ala Ile Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn 
1               5                   10                  15      


Ser Asp Tyr 
            


<210> 269
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 269
Ser Gly Ser Gly Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val 
1               5                   10                  15      


Asn Val Phe 
            


<210> 270
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 270
Ser Gly Ser Gly Val Asn Ser Asp Tyr Asn Val Asn Val Phe Tyr Asp 
1               5                   10                  15      


Ser Asn Ala 
            


<210> 271
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 271
Ser Gly Ser Gly Leu Lys Lys Thr Val Val Glu Ser Ala Ile Asn Asp 
1               5                   10                  15      


Thr Leu Glu 
            


<210> 272
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 272
Ser Gly Ser Gly Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe 
1               5                   10                  15      


Arg Glu Asn 
            


<210> 273
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 273
Ser Gly Ser Gly Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu Asn 
1               5                   10                  15      


Asp Pro Arg 
            


<210> 274
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 274
Ser Gly Ser Gly Ser Phe Arg Glu Asn Leu Asn Asp Pro Arg Phe Asp 
1               5                   10                  15      


Tyr Asn Lys 
            


<210> 275
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 275
Ser Gly Ser Gly Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe 
1               5                   10                  15      


Arg Lys Arg 
            


<210> 276
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 276
Ser Gly Ser Gly Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu 
1               5                   10                  15      


Ile Ile Tyr 
            


<210> 277
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 277
Ser Gly Ser Gly Phe Phe Arg Lys Arg Met Glu Ile Ile Tyr Asp Lys 
1               5                   10                  15      


Gln Lys Asn 
            


<210> 278
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 278
Ser Gly Ser Gly Met Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile 
1               5                   10                  15      


Asn Tyr Tyr 
            


<210> 279
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 279
Ser Gly Ser Gly Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
1               5                   10                  15      


Gln Arg Glu 
            


<210> 280
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 280
Ser Gly Ser Gly Phe Ile Asn Tyr Tyr Lys Ala Gln Arg Glu Glu Asn 
1               5                   10                  15      


Pro Glu Leu 
            


<210> 281
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 281
Ser Gly Ser Gly Lys Ala Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile 
1               5                   10                  15      


Asp Asp Ile 
            


<210> 282
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 282
Ser Gly Ser Gly Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys 
1               5                   10                  15      


Thr Tyr Leu 
            


<210> 283
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 283
Ser Gly Ser Gly Ile Ile Asp Asp Ile Val Lys Thr Tyr Leu Ser Asn 
1               5                   10                  15      


Glu Tyr Ser 
            


<210> 284
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 284
Ser Gly Ser Gly Val Lys Thr Tyr Leu Ser Asn Glu Tyr Ser Lys Glu 
1               5                   10                  15      


Ile Asp Glu 
            


<210> 285
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 285
Ser Gly Ser Gly Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn 
1               5                   10                  15      


Thr Tyr Ile 
            


<210> 286
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 286
Ser Gly Ser Gly Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile Glu Glu 
1               5                   10                  15      


Ser Leu Asn 
            


<210> 287
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 287
Ser Gly Ser Gly Leu Asn Thr Tyr Ile Glu Glu Ser Leu Asn Lys Ile 
1               5                   10                  15      


Thr Gln Asn 
            


<210> 288
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 288
Ser Gly Ser Gly Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly 
1               5                   10                  15      


Asn Asp Val 
            


<210> 289
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 289
Ser Gly Ser Gly Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg Asn 
1               5                   10                  15      


Phe Gly Glu 
            


<210> 290
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 290
Ser Gly Ser Gly Ser Gly Asn Asp Val Arg Asn Phe Gly Glu Phe Lys 
1               5                   10                  15      


Asn Gly Glu 
            


<210> 291
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 291
Ser Gly Ser Gly Arg Asn Phe Gly Glu Phe Lys Asn Gly Glu Ser Phe 
1               5                   10                  15      


Asn Leu Tyr 
            


<210> 292
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 292
Ser Gly Ser Gly Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln 
1               5                   10                  15      


Glu Leu Val 
            


<210> 293
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 293
Ser Gly Ser Gly Asp Val Asp Met Leu Pro Gly Ile Gln Pro Asp Leu 
1               5                   10                  15      


Phe Glu Ser 
            


<210> 294
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 294
Ser Gly Ser Gly Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu 
1               5                   10                  15      


Lys Pro Ser 
            


<210> 295
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 295
Ser Gly Ser Gly Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser Ser Val 
1               5                   10                  15      


Thr Val Asp 
            


<210> 296
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 296
Ser Gly Ser Gly Ile Glu Lys Pro Ser Ser Val Thr Val Asp Phe Trp 
1               5                   10                  15      


Glu Met Thr 
            


<210> 297
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 297
Ser Gly Ser Gly Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu 
1               5                   10                  15      


Glu Ala Ile 
            


<210> 298
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 298
Ser Gly Ser Gly Lys Leu Glu Ala Ile Met Lys Tyr Lys Glu Tyr Ile 
1               5                   10                  15      


Pro Glu Tyr 
            


<210> 299
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 299
Ser Gly Ser Gly Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser 
1               5                   10                  15      


Glu His Phe 
            


<210> 300
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 300
Ser Gly Ser Gly Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met 
1               5                   10                  15      


Leu Asp Glu 
            


<210> 301
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 301
Ser Gly Ser Gly Thr Ser Glu His Phe Asp Met Leu Asp Glu Glu Val 
1               5                   10                  15      


Gln Ser Ser 
            


<210> 302
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 302
Ser Gly Ser Gly Asp Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu 
1               5                   10                  15      


Ser Val Leu 
            


<210> 303
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 303
Ser Gly Ser Gly Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
1               5                   10                  15      


Lys Ser Asp 
            


<210> 304
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 304
Ser Gly Ser Gly Phe Glu Ser Val Leu Ala Ser Lys Ser Asp Lys Ser 
1               5                   10                  15      


Glu Ile Phe 
            


<210> 305
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 305
Ser Gly Ser Gly Ala Ser Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser 
1               5                   10                  15      


Leu Gly Asp 
            


<210> 306
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 306
Ser Gly Ser Gly Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu 
1               5                   10                  15      


Ala Ser Pro 
            


<210> 307
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 307
Ser Gly Ser Gly Ser Ser Leu Gly Asp Met Glu Ala Ser Pro Leu Glu 
1               5                   10                  15      


Val Lys Ile 
            


<210> 308
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 308
Ser Gly Ser Gly Met Glu Ala Ser Pro Leu Glu Val Lys Ile Ala Phe 
1               5                   10                  15      


Asn Ser Lys 
            


<210> 309
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 309
Ser Gly Ser Gly Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile 
1               5                   10                  15      


Ile Asn Gln 
            


<210> 310
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 310
Ser Gly Ser Gly Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln Gly Leu 
1               5                   10                  15      


Ile Ser Val 
            


<210> 311
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 311
Ser Gly Ser Gly Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys Gln 
1               5                   10                  15      


Ile Glu Asn 
            


<210> 312
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 312
Ser Gly Ser Gly Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn 
1               5                   10                  15      


Ser Leu Asn 
            


<210> 313
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 313
Ser Gly Ser Gly Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala 
1               5                   10                  15      


Ile Ser Glu 
            


<210> 314
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 314
Ser Gly Ser Gly Asn Asn Ser Leu Asn Pro Ala Ile Ser Glu Asp Asn 
1               5                   10                  15      


Asp Phe Asn 
            


<210> 315
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 315
Ser Gly Ser Gly Pro Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr 
1               5                   10                  15      


Thr Asn Thr 
            


<210> 316
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 316
Ser Gly Ser Gly Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
1               5                   10                  15      


Asp Ser Ile 
            


<210> 317
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 317
Ser Gly Ser Gly Thr Thr Thr Asn Thr Phe Ile Asp Ser Ile Met Ala 
1               5                   10                  15      


Glu Ala Asn 
            


<210> 318
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 318
Ser Gly Ser Gly Phe Ile Asp Ser Ile Met Ala Glu Ala Asn Ala Asp 
1               5                   10                  15      


Asn Gly Arg 
            


<210> 319
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 319
Ser Gly Ser Gly Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met 
1               5                   10                  15      


Met Glu Leu 
            


<210> 320
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 320
Ser Gly Ser Gly Ala Asp Asn Gly Arg Phe Met Met Glu Leu Gly Lys 
1               5                   10                  15      


Tyr Leu Arg 
            


<210> 321
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 321
Ser Gly Ser Gly Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His 
1               5                   10                  15      


Leu Ile Glu 
            


<210> 322
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 322
Ser Gly Ser Gly Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp 
1               5                   10                  15      


Leu Arg Asn 
            


<210> 323
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 323
Ser Gly Ser Gly Ile His Leu Ile Glu Ala Asp Leu Arg Asn Phe Glu 
1               5                   10                  15      


Ile Ser Lys 
            


<210> 324
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 324
Ser Gly Ser Gly Ala Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn 
1               5                   10                  15      


Ile Ser Gln 
            


<210> 325
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 325
Ser Gly Ser Gly Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
1               5                   10                  15      


Glu Gln Glu 
            


<210> 326
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 326
Ser Gly Ser Gly Thr Asn Ile Ser Gln Ser Thr Glu Gln Glu Met Ala 
1               5                   10                  15      


Ser Leu Trp 
            


<210> 327
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 327
Ser Gly Ser Gly Ser Thr Glu Gln Glu Met Ala Ser Leu Trp Ser Phe 
1               5                   10                  15      


Asp Asp Ala 
            


<210> 328
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 328
Ser Gly Ser Gly Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala 
1               5                   10                  15      


Lys Ala Gln 
            


<210> 329
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 329
Ser Gly Ser Gly Ser Phe Asp Asp Ala Arg Ala Lys Ala Gln Phe Glu 
1               5                   10                  15      


Glu Tyr Lys 
            


<210> 330
<211> 19
<212> PRT
<213> Clostridium difficile

<400> 330
Ser Gly Ser Gly Arg Ala Lys Ala Gln Phe Glu Glu Tyr Lys Arg Asn 
1               5                   10                  15      


Tyr Phe Glu 
            


<210> 331
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 331
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 332
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 332
His His His His His His 
1               5       


<210> 333
<211> 20
<212> PRT
<213> Clostridium difficile

<400> 333
Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu 
1               5                   10                  15      


Asn Thr Ala Glu 
            20  


<210> 334
<211> 20
<212> PRT
<213> Clostridium difficile

<400> 334
Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr 
1               5                   10                  15      


Asn Thr Phe Ile 
            20  


<210> 335
<211> 20
<212> PRT
<213> Clostridium difficile

<400> 335
Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr 
1               5                   10                  15      


Asn Thr Ser Ile 
            20  


<210> 336
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      motif which allows for sortase-catalyzed conjugation
      of labels, such as biotin

<400> 336
Leu Pro Glu Thr Gly 
1               5   


<210> 337
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      mutated peptide

<400> 337
Ala Gly Ala Asn Lys 
1               5   


<210> 338
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 338
Met Ser Gly Leu Val Pro Arg Gly Ser His Met Ser Leu Val Asn Arg 
1               5                   10                  15      


Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe Arg Thr Gln Glu Asp 
            20                  25                  30          


Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu Tyr His Asn Met Ser 
        35                  40                  45              


Glu Asn Thr Val Val Glu Lys Tyr Leu Lys Leu Lys Asp Ile Asn Ser 
    50                  55                  60                  


Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys Ser Gly Arg Asn Lys 
65                  70                  75                  80  


Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr Glu Val Leu Glu Leu 
                85                  90                  95      


Lys Asn Asn Asn Leu Leu Pro Glu Thr Gly Gly His His His His His 
            100                 105                 110         


His 
    


<210> 339
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 339
Met Ser Gly Leu Val Pro Arg Gly Ser His Met Ser Leu Val Asn Arg 
1               5                   10                  15      


Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe Arg Thr Gln Glu Asp 
            20                  25                  30          


Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu Tyr His Asn Met Ser 
        35                  40                  45              


Glu Asn Thr Val Val Glu Lys Tyr Leu Lys Leu Lys Asp Ile Asn Ser 
    50                  55                  60                  


Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys Ala Gly Ala Asn Lys 
65                  70                  75                  80  


Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr Glu Val Leu Glu Leu 
                85                  90                  95      


Lys Asn Asn Asn Leu Leu Pro Glu Thr Gly Gly His His His His His 
            100                 105                 110         


His 
    


<210> 340
<211> 464
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 340
Met Glu Lys Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp 
1               5                   10                  15      


Thr Ala Ile Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr 
            20                  25                  30          


Asn Val Asn Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu 
        35                  40                  45              


Lys Lys Thr Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe 
    50                  55                  60                  


Arg Glu Asn Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg 
65                  70                  75                  80  


Lys Arg Met Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr 
                85                  90                  95      


Tyr Lys Ala Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile 
            100                 105                 110         


Val Lys Thr Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu 
        115                 120                 125             


Asn Thr Tyr Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly 
    130                 135                 140                 


Asn Asp Val Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn 
145                 150                 155                 160 


Leu Tyr Glu Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser 
                165                 170                 175     


Asp Ile Leu Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu 
            180                 185                 190         


Asp Val Asp Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile 
        195                 200                 205             


Glu Lys Pro Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu 
    210                 215                 220                 


Glu Ala Ile Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu 
225                 230                 235                 240 


His Phe Asp Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val 
                245                 250                 255     


Leu Ala Ser Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp 
            260                 265                 270         


Met Glu Ala Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly 
        275                 280                 285             


Ile Ile Asn Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn 
    290                 295                 300                 


Leu Ile Val Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser 
305                 310                 315                 320 


Leu Asn Pro Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn 
                325                 330                 335     


Thr Phe Ile Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg 
            340                 345                 350         


Phe Met Met Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp 
        355                 360                 365             


Val Lys Thr Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala 
    370                 375                 380                 


Tyr Gln Asp Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu 
385                 390                 395                 400 


Ile Glu Ala Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser 
                405                 410                 415     


Gln Ser Thr Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala 
            420                 425                 430         


Arg Ala Lys Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly 
        435                 440                 445             


Ser Leu Gly Glu Leu Pro Glu Thr Gly Gly His His His His His His 
    450                 455                 460                 
