                         SEQUENCE LISTING

<110>  Wageningen Universiteit
 
<120>  Fungal strains with improved citric acid and itaconic acid 
       production

<130>  P6043692PCT

<160>  58    

<170>  PatentIn version 3.3

<210>  1
<211>  1440
<212>  DNA
<213>  Rhizopus oryzae

<400>  1
atgaacaact ctcctcgtct tttcagtagt gcctctgctg ctttgcaaaa attccgtgct     60

gagcgcgata cttttggtga tctccaagtt cctgctgata gatattgggg tgctcaaacc    120

caaaggtctc ttcaaaattt tgacattggt ggccctactg aacgtatgcc cgaacctttg    180

atccgtgcct ttggtgtcct caaaaaggct gctgctactg tcaacatgac ttatggcttg    240

gatcctaaag ttggtgaagc tattcaaaag gctgctgacg aggtcattga tggaagcttg    300

attgatcatt tccctcttgt tgtctggcaa actggttccg gtactcaaac caagatgaac    360

gttaacgaag ttatctccaa ccgtgctatt gaacttttgg gtggtgagct tggtagtaag    420

gctcctgttc atcccaacga tcatgtcaac atgagtcaat catccaatga cacgttccct    480

actgccatgc acgttgctgc tgttgttgaa attcacggtc gacttattcc tgctttgacc    540

actttgcgtg atgcccttca agccaaatcc gctgagtttg aacacatcat caagatcggt    600

cgtactcact tgcaagatgc aactcctttg actctcggtc aagaattctc tggttatact    660

caacaattga cttacggtat tgctcgtgta caaggtacct tggagcgcct ctataacctt    720

gctcaaggtg gtactgctgt tggtactggt cttaacacca gaaaaggttt cgatgccaag    780

gtagctgaag ctattgcttc tattaccggt cttcctttca agaccgcccc taataagttt    840

gaagcccttg ctgctcacga tgctctcgtt gaagctcacg gagctctcaa taccgttgct    900

tgttctctta tgaagatcgc caacgatatc cgttatcttg gttctggacc tcgctgtggt    960

cttggtgaac tttccttgcc tgaaaacgaa cccggatctt ctatcatgcc cggtaaggtt   1020

aatcctactc aatgtgaagc tatgaccatg gtctgtgctc aagtcatggg taacaacact   1080

gctatttctg ttgctggttc caatggtcaa ttcgagctta atgtcttcaa acccgtcatg   1140

atcaagaact tgatccaatc cattcgtctt atttctgatg cctctatttc attcaccaaa   1200

aactgtgttg ttggtattga agccaatgaa aagaagatta gcagcattat gaatgagtca   1260

ttgatgttgg tcactgctct taaccctcat attggttacg ataaagctgc taaatgtgcc   1320

aagaaggccc acaaggaagg caccaccttg aaggaagctg ccctttctct tggttacttg   1380

acttctgaag aattcgacca gtgggttaga cccgaagata tgatctctgc caaggattaa   1440


<210>  2
<211>  479
<212>  PRT
<213>  Rhizopus oryzae

<400>  2

Met Asn Asn Ser Pro Arg Leu Phe Ser Ser Ala Ser Ala Ala Leu Gln 
1               5                   10                  15      


Lys Phe Arg Ala Glu Arg Asp Thr Phe Gly Asp Leu Gln Val Pro Ala 
            20                  25                  30          


Asp Arg Tyr Trp Gly Ala Gln Thr Gln Arg Ser Leu Gln Asn Phe Asp 
        35                  40                  45              


Ile Gly Gly Pro Thr Glu Arg Met Pro Glu Pro Leu Ile Arg Ala Phe 
    50                  55                  60                  


Gly Val Leu Lys Lys Ala Ala Ala Thr Val Asn Met Thr Tyr Gly Leu 
65                  70                  75                  80  


Asp Pro Lys Val Gly Glu Ala Ile Gln Lys Ala Ala Asp Glu Val Ile 
                85                  90                  95      


Asp Gly Ser Leu Ile Asp His Phe Pro Leu Val Val Trp Gln Thr Gly 
            100                 105                 110         


Ser Gly Thr Gln Thr Lys Met Asn Val Asn Glu Val Ile Ser Asn Arg 
        115                 120                 125             


Ala Ile Glu Leu Leu Gly Gly Glu Leu Gly Ser Lys Ala Pro Val His 
    130                 135                 140                 


Pro Asn Asp His Val Asn Met Ser Gln Ser Ser Asn Asp Thr Phe Pro 
145                 150                 155                 160 


Thr Ala Met His Val Ala Ala Val Val Glu Ile His Gly Arg Leu Ile 
                165                 170                 175     


Pro Ala Leu Thr Thr Leu Arg Asp Ala Leu Gln Ala Lys Ser Ala Glu 
            180                 185                 190         


Phe Glu His Ile Ile Lys Ile Gly Arg Thr His Leu Gln Asp Ala Thr 
        195                 200                 205             


Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Thr Gln Gln Leu Thr 
    210                 215                 220                 


Tyr Gly Ile Ala Arg Val Gln Gly Thr Leu Glu Arg Leu Tyr Asn Leu 
225                 230                 235                 240 


Ala Gln Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Lys Gly 
                245                 250                 255     


Phe Asp Ala Lys Val Ala Glu Ala Ile Ala Ser Ile Thr Gly Leu Pro 
            260                 265                 270         


Phe Lys Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp Ala 
        275                 280                 285             


Leu Val Glu Ala His Gly Ala Leu Asn Thr Val Ala Cys Ser Leu Met 
    290                 295                 300                 


Lys Ile Ala Asn Asp Ile Arg Tyr Leu Gly Ser Gly Pro Arg Cys Gly 
305                 310                 315                 320 


Leu Gly Glu Leu Ser Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile Met 
                325                 330                 335     


Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val Cys 
            340                 345                 350         


Ala Gln Val Met Gly Asn Asn Thr Ala Ile Ser Val Ala Gly Ser Asn 
        355                 360                 365             


Gly Gln Phe Glu Leu Asn Val Phe Lys Pro Val Met Ile Lys Asn Leu 
    370                 375                 380                 


Ile Gln Ser Ile Arg Leu Ile Ser Asp Ala Ser Ile Ser Phe Thr Lys 
385                 390                 395                 400 


Asn Cys Val Val Gly Ile Glu Ala Asn Glu Lys Lys Ile Ser Ser Ile 
                405                 410                 415     


Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile Gly 
            420                 425                 430         


Tyr Asp Lys Ala Ala Lys Cys Ala Lys Lys Ala His Lys Glu Gly Thr 
        435                 440                 445             


Thr Leu Lys Glu Ala Ala Leu Ser Leu Gly Tyr Leu Thr Ser Glu Glu 
    450                 455                 460                 


Phe Asp Gln Trp Val Arg Pro Glu Asp Met Ile Ser Ala Lys Asp 
465                 470                 475                 


<210>  3
<211>  1446
<212>  DNA
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  3
atgcataact ctccacgcct gttctctagc gcttccgctg cactccaaaa gtttcgcgct     60

gagcgcgata ctttcggaga tcttcaggtc cctgccgacc gttactgggg tgcccagacc    120

cagcgctcgt tgcagaattt cgatattggt ggtcccaccg aacgtatgcc ggagcccctt    180

attcgcgctt tcggagtgtt gaaaaaggcc gcagccacag ttaacatgac ctacggtctg    240

gaccccaagg tgggcgaggc tatccaaaag gcggctgacg aagtcatcga tggatccctc    300

atcgaccact tccctctggt cgtctggcaa accggcagcg gcacgcagac aaagatgaat    360

gtcaacgagg tcatctctaa ccgtgcaatc gagcttctcg gcggtgagct gggatccaag    420

gcccctgtcc accctaacga ccacgtcaat atgtcgcagt cctctaacga caccttcccc    480

accgccatgc acgtggcggc agtggttgaa atccatggac gtctgatccc tgccctcacc    540

accctgcgcg acgccctgca ggctaagagt gcagagttcg agcacatcat taagattggt    600

cgcacccatc tgcaggacgc cactccgttg acccttggcc aggagttttc tggctacacc    660

caacagctca cgtacggtat cgctcgggtt caaggcacgc tcgaacgcct ttacaacctt    720

gcgcagggcg gtactgccgt cggcacaggc ttgaacaccc gtaagggatt tgatgctaag    780

gtggccgagg ccattgcttc cattaccggc ctccccttta agaccgctcc aaacaagttc    840

gaggcccttg cggctcatga cgccctggtg gaggcacatg gcgccttgaa cacggtcgcg    900

tgctcgctga tgaagattgc gaacgatatc cggtacctcg gctctggacc gcgctgcggt    960

ctgggtgagc tcagcttgcc ggagaacgag cccggtagtt ctatcatgcc aggcaaggtt   1020

aacccgaccc agtgtgaggc gatgactatg gtctgtgctc aggtcatggg aaacaacact   1080

gcgatcagtg ttgccggatc caacggtcag ttcgaattga acgttttcaa gcccgttatg   1140

atcaaaaacc tcattcagtc gatccggctg atttcggacg cctcgatcag cttcacgaaa   1200

aactgcgttg tgggtatcga agctaatgag aaaaagattt cgagcatcat gaatgaatcc   1260

ttgatgctcg tgactgccct caatccccac atcggttatg ataaggctgc taagtgcgcc   1320

aaaaaggccc acaaggaggg cactactctt aaggaggcag ccctgagcct gggctatctc   1380

acatccgagg agttcgatca atgggtgcgt cccgaagata tgatcagcgc caaggattaa   1440

gcggcc                                                              1446


<210>  4
<211>  479
<212>  PRT
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  4

Met His Asn Ser Pro Arg Leu Phe Ser Ser Ala Ser Ala Ala Leu Gln 
1               5                   10                  15      


Lys Phe Arg Ala Glu Arg Asp Thr Phe Gly Asp Leu Gln Val Pro Ala 
            20                  25                  30          


Asp Arg Tyr Trp Gly Ala Gln Thr Gln Arg Ser Leu Gln Asn Phe Asp 
        35                  40                  45              


Ile Gly Gly Pro Thr Glu Arg Met Pro Glu Pro Leu Ile Arg Ala Phe 
    50                  55                  60                  


Gly Val Leu Lys Lys Ala Ala Ala Thr Val Asn Met Thr Tyr Gly Leu 
65                  70                  75                  80  


Asp Pro Lys Val Gly Glu Ala Ile Gln Lys Ala Ala Asp Glu Val Ile 
                85                  90                  95      


Asp Gly Ser Leu Ile Asp His Phe Pro Leu Val Val Trp Gln Thr Gly 
            100                 105                 110         


Ser Gly Thr Gln Thr Lys Met Asn Val Asn Glu Val Ile Ser Asn Arg 
        115                 120                 125             


Ala Ile Glu Leu Leu Gly Gly Glu Leu Gly Ser Lys Ala Pro Val His 
    130                 135                 140                 


Pro Asn Asp His Val Asn Met Ser Gln Ser Ser Asn Asp Thr Phe Pro 
145                 150                 155                 160 


Thr Ala Met His Val Ala Ala Val Val Glu Ile His Gly Arg Leu Ile 
                165                 170                 175     


Pro Ala Leu Thr Thr Leu Arg Asp Ala Leu Gln Ala Lys Ser Ala Glu 
            180                 185                 190         


Phe Glu His Ile Ile Lys Ile Gly Arg Thr His Leu Gln Asp Ala Thr 
        195                 200                 205             


Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Thr Gln Gln Leu Thr 
    210                 215                 220                 


Tyr Gly Ile Ala Arg Val Gln Gly Thr Leu Glu Arg Leu Tyr Asn Leu 
225                 230                 235                 240 


Ala Gln Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Lys Gly 
                245                 250                 255     


Phe Asp Ala Lys Val Ala Glu Ala Ile Ala Ser Ile Thr Gly Leu Pro 
            260                 265                 270         


Phe Lys Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp Ala 
        275                 280                 285             


Leu Val Glu Ala His Gly Ala Leu Asn Thr Val Ala Cys Ser Leu Met 
    290                 295                 300                 


Lys Ile Ala Asn Asp Ile Arg Tyr Leu Gly Ser Gly Pro Arg Cys Gly 
305                 310                 315                 320 


Leu Gly Glu Leu Ser Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile Met 
                325                 330                 335     


Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val Cys 
            340                 345                 350         


Ala Gln Val Met Gly Asn Asn Thr Ala Ile Ser Val Ala Gly Ser Asn 
        355                 360                 365             


Gly Gln Phe Glu Leu Asn Val Phe Lys Pro Val Met Ile Lys Asn Leu 
    370                 375                 380                 


Ile Gln Ser Ile Arg Leu Ile Ser Asp Ala Ser Ile Ser Phe Thr Lys 
385                 390                 395                 400 


Asn Cys Val Val Gly Ile Glu Ala Asn Glu Lys Lys Ile Ser Ser Ile 
                405                 410                 415     


Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile Gly 
            420                 425                 430         


Tyr Asp Lys Ala Ala Lys Cys Ala Lys Lys Ala His Lys Glu Gly Thr 
        435                 440                 445             


Thr Leu Lys Glu Ala Ala Leu Ser Leu Gly Tyr Leu Thr Ser Glu Glu 
    450                 455                 460                 


Phe Asp Gln Trp Val Arg Pro Glu Asp Met Ile Ser Ala Lys Asp 
465                 470                 475                 


<210>  5
<211>  3579
<212>  DNA
<213>  Aspergillus niger

<400>  5
atggctgctc cccgccagcc cgaggaggcg gtcgatgaca ccgagttcat cgatgaccac     60

catgaccagc accgggactc tgtccacacc cgtctgcgtg ccaattcggc catcatgcag    120

ttccaaaaga tccttgttgc caaccgtggt gaaatcccca ttcgtatctt ccggacggct    180

cacgagctgt ccctgcagac tgtcgccgtc tactcccatg aggaccgtct ctccatgcac    240

cgtcagaagg ccgacgaggc ctacatgatt ggcaagcgcg gtcaatatac accggtcggg    300

gcctacttgg ccattgacga gatcgtcaag attgctctgg agcatggtgt acacctgatc    360

cacccgggtt acggtttcct gtccgagaac gccgagtttg cccgcaaggt ggagcagtcc    420

ggcatggttt tcgtcggccc taccccccag accatcgaga gcctcggtga caaggtctcc    480

gcccgtcagc tggctatccg ctgcgatgtg cccgtcgtgc ccggtacccc gggccctgtc    540

gagcgctacg aggaggtcaa ggccttcacc gacacctacg gcttccccat catcatcaag    600

gccgcctttg gtggtggtgg tcgtggtatg cgtgtcgttc gcgaccaggc cgaactgcgt    660

gactccttcg agcgtgccac ctccgaggcc cgctctgcct ttggcaacgg caccgtcttc    720

gtcgagcgct tcctcgaccg ccccaagcac atcgaagtcc agctgctggg tgacaaccac    780

ggcaacgtcg tccacctgtt cgagcgtgac tgctccgtcc aacgtcgcca ccagaaggtc    840

gttgaaattg ccccggccaa ggacctgcct gccgatgtcc gtgaccgcat cctggctgat    900

gctgtcaagc tggccaagtc ggtcaactac cgcaacgccg gtactgcaga gttcctggtt    960

gaccagcaga accgttacta cttcattgag atcaaccccc gtatccaggt cgagcacact   1020

atcaccgaag agatcacggg tatcgatatt gttgctgctc agatccagat tgcggccggt   1080

gctaccctgg aacagctggg tctgacccag gaccgcatct ccactcgtgg attcgccatt   1140

cagtgccgta tcaccaccga ggacccctcc aagggcttct cccccgacac cggtaagatc   1200

gaggtctacc gctccgccgg tggtaacggt gtccgtctgg atggtggaaa cggtttcgcc   1260

ggtgccatca tcacccctca ctacgactcc atgttggtca agtgtacctg ccgtggttcc   1320

acctatgaga tcgctcgccg caaggtcgtt cgtgctttgg tcgagttccg tatccgtggt   1380

gtcaagacca acattccttt cctcacctct cttctgagtc accctgtgtt cgtggatggt   1440

acctgctgga ccacgttcat tgatgacact cccgagctgt tcgcccttgt cggcagtcag   1500

aaccgtgccc agaagctgct ggcttacctg ggtgatgtgg ctgtcaacgg cagcagcatc   1560

aagggccaga tcggcgagcc caagctcaag ggcgatatca tcaagcccgt tctgcatgac   1620

gctgccggca agcccctcga cgtctctgtc cccgccacca agggatggaa gcagatcctg   1680

gacagtgagg gtcccgaggc ttttgcccgc gctgtgcgtg ccaacaaggg ctgcttgatc   1740

atggatacta cctggcgtga tgcccaccag tcgctgctgg ccactcgtgt gcgtaccatt   1800

gacctcctga acatcgccca cgagacgagc cacgccctcg ccaacgccta cagtttggaa   1860

tgctggggtg gtgccacctt cgatgtcgcc atgcgcttcc tgtacgagga cccctgggac   1920

cgtcttcgca agctgcgcaa ggccgttccc aacatcccct tccagatgtt gctccgtggt   1980

gccaacggtg ttgcttactc ctccctccct gacaacgcca tctaccactt ctgtaagcag   2040

gccaagaagt gcggtgtcga catcttccgt gtcttcgatg ctctcaacga cgttgaccag   2100

ctcgaggtcg gtatcaaggc tgtccacgct gccgagggtg ttgttgaggc tactatttgc   2160

tacagtggtg atatgctcaa ccccagcaag aagtacaacc tgccttacta cctcgacctt   2220

gttgataagg tggtccagtt caagccccac gtcttgggta tcaaggacat ggctggtgtg   2280

ctgaagcccc aggctgctcg tctgctgatc ggttccatcc gcgagcgcta ccccgacctc   2340

cccatccacg tgcacaccca cgactctgct ggtaccggtg tggcttccat gattgcttgc   2400

gctcaggccg gtgctgatgc cgttgatgct gccacggaca gcctttccgg tatgacctcc   2460

cagcccagca ttggtgctat cctcgcttcc ctcgagggaa ctgagcacga ccccggcctc   2520

aactcggccc aggttcgcgc ccttgacacc tactgggcgc agctgcgtct cctctactcg   2580

cccttcgagg caggtctgac tggtcccgac cccgaggttt acgagcatga gatccctggt   2640

ggtcaattga ccaacctgat cttccaggcc agccagcttg gtctgggcca gcagtgggcg   2700

gagacgaaga aggcttacga gtctgccaac gatcttttgg gcgatgtcgt caaggtcacc   2760

cccacttcca aggtggtcgg tgatttggct cagttcatgg tctccaacaa gttgactgct   2820

gaagatgtga ttgctcgcgc cggcgagctt gacttccccg gttccgttct ggagttcctc   2880

gagggtctca tgggccagcc ctacggtggg ttccccgagc ctctgcgctc tcgcgctctg   2940

cgtgaccgtc gcaagctcga caagcgccct ggtctgtacc tggagcccct tgacctggcc   3000

aagatcaaga gccagatccg ggagaactat ggcgcagcta ccgagtacga tgtggccagc   3060

tatgccatgt accccaaggt cttcgaggat tacaagaagt ttgtcgccaa gttcggtgat   3120

ttgtccgtcc tgcccacccg ttacttcttg gccaagcccg agatcggcga ggaattccac   3180

gtcgagctgg agaagggtaa ggtgctgatc ctgaagttgt tggccattgg tcccctctcc   3240

gagcagaccg gccagcgtga ggtcttctac gaagtcaacg gtgaggttcg ccaggttagt   3300

gtggacgaca agaaggcgtc cgtcgagaac accgcccgcc ccaaggccga gctgggtgac   3360

agcagccagg ttggtgctcc tatgagcggt gtggttgtcg agatccgcgt ccacgacggc   3420

ctggaagtca agaagggtga ccccattgcc gtcctgagcg ccatgaagat ggaaatggtt   3480

atctctgctc cccacagtgg caaggtctcc agcttgctgg tcaaggaagg tgactcggtg   3540

gatggccagg atcttgtctg caagatcgtc aaggcctag                          3579


<210>  6
<211>  1192
<212>  PRT
<213>  Aspergillus niger

<400>  6

Met Ala Ala Pro Arg Gln Pro Glu Glu Ala Val Asp Asp Thr Glu Phe 
1               5                   10                  15      


Ile Asp Asp His His Asp Gln His Arg Asp Ser Val His Thr Arg Leu 
            20                  25                  30          


Arg Ala Asn Ser Ala Ile Met Gln Phe Gln Lys Ile Leu Val Ala Asn 
        35                  40                  45              


Arg Gly Glu Ile Pro Ile Arg Ile Phe Arg Thr Ala His Glu Leu Ser 
    50                  55                  60                  


Leu Gln Thr Val Ala Val Tyr Ser His Glu Asp Arg Leu Ser Met His 
65                  70                  75                  80  


Arg Gln Lys Ala Asp Glu Ala Tyr Met Ile Gly Lys Arg Gly Gln Tyr 
                85                  90                  95      


Thr Pro Val Gly Ala Tyr Leu Ala Ile Asp Glu Ile Val Lys Ile Ala 
            100                 105                 110         


Leu Glu His Gly Val His Leu Ile His Pro Gly Tyr Gly Phe Leu Ser 
        115                 120                 125             


Glu Asn Ala Glu Phe Ala Arg Lys Val Glu Gln Ser Gly Met Val Phe 
    130                 135                 140                 


Val Gly Pro Thr Pro Gln Thr Ile Glu Ser Leu Gly Asp Lys Val Ser 
145                 150                 155                 160 


Ala Arg Gln Leu Ala Ile Arg Cys Asp Val Pro Val Val Pro Gly Thr 
                165                 170                 175     


Pro Gly Pro Val Glu Arg Tyr Glu Glu Val Lys Ala Phe Thr Asp Thr 
            180                 185                 190         


Tyr Gly Phe Pro Ile Ile Ile Lys Ala Ala Phe Gly Gly Gly Gly Arg 
        195                 200                 205             


Gly Met Arg Val Val Arg Asp Gln Ala Glu Leu Arg Asp Ser Phe Glu 
    210                 215                 220                 


Arg Ala Thr Ser Glu Ala Arg Ser Ala Phe Gly Asn Gly Thr Val Phe 
225                 230                 235                 240 


Val Glu Arg Phe Leu Asp Arg Pro Lys His Ile Glu Val Gln Leu Leu 
                245                 250                 255     


Gly Asp Asn His Gly Asn Val Val His Leu Phe Glu Arg Asp Cys Ser 
            260                 265                 270         


Val Gln Arg Arg His Gln Lys Val Val Glu Ile Ala Pro Ala Lys Asp 
        275                 280                 285             


Leu Pro Ala Asp Val Arg Asp Arg Ile Leu Ala Asp Ala Val Lys Leu 
    290                 295                 300                 


Ala Lys Ser Val Asn Tyr Arg Asn Ala Gly Thr Ala Glu Phe Leu Val 
305                 310                 315                 320 


Asp Gln Gln Asn Arg Tyr Tyr Phe Ile Glu Ile Asn Pro Arg Ile Gln 
                325                 330                 335     


Val Glu His Thr Ile Thr Glu Glu Ile Thr Gly Ile Asp Ile Val Ala 
            340                 345                 350         


Ala Gln Ile Gln Ile Ala Ala Gly Ala Thr Leu Glu Gln Leu Gly Leu 
        355                 360                 365             


Thr Gln Asp Arg Ile Ser Thr Arg Gly Phe Ala Ile Gln Cys Arg Ile 
    370                 375                 380                 


Thr Thr Glu Asp Pro Ser Lys Gly Phe Ser Pro Asp Thr Gly Lys Ile 
385                 390                 395                 400 


Glu Val Tyr Arg Ser Ala Gly Gly Asn Gly Val Arg Leu Asp Gly Gly 
                405                 410                 415     


Asn Gly Phe Ala Gly Ala Ile Ile Thr Pro His Tyr Asp Ser Met Leu 
            420                 425                 430         


Val Lys Cys Thr Cys Arg Gly Ser Thr Tyr Glu Ile Ala Arg Arg Lys 
        435                 440                 445             


Val Val Arg Ala Leu Val Glu Phe Arg Ile Arg Gly Val Lys Thr Asn 
    450                 455                 460                 


Ile Pro Phe Leu Thr Ser Leu Leu Ser His Pro Val Phe Val Asp Gly 
465                 470                 475                 480 


Thr Cys Trp Thr Thr Phe Ile Asp Asp Thr Pro Glu Leu Phe Ala Leu 
                485                 490                 495     


Val Gly Ser Gln Asn Arg Ala Gln Lys Leu Leu Ala Tyr Leu Gly Asp 
            500                 505                 510         


Val Ala Val Asn Gly Ser Ser Ile Lys Gly Gln Ile Gly Glu Pro Lys 
        515                 520                 525             


Leu Lys Gly Asp Ile Ile Lys Pro Val Leu His Asp Ala Ala Gly Lys 
    530                 535                 540                 


Pro Leu Asp Val Ser Val Pro Ala Thr Lys Gly Trp Lys Gln Ile Leu 
545                 550                 555                 560 


Asp Ser Glu Gly Pro Glu Ala Phe Ala Arg Ala Val Arg Ala Asn Lys 
                565                 570                 575     


Gly Cys Leu Ile Met Asp Thr Thr Trp Arg Asp Ala His Gln Ser Leu 
            580                 585                 590         


Leu Ala Thr Arg Val Arg Thr Ile Asp Leu Leu Asn Ile Ala His Glu 
        595                 600                 605             


Thr Ser His Ala Leu Ala Asn Ala Tyr Ser Leu Glu Cys Trp Gly Gly 
    610                 615                 620                 


Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Asp Pro Trp Asp 
625                 630                 635                 640 


Arg Leu Arg Lys Leu Arg Lys Ala Val Pro Asn Ile Pro Phe Gln Met 
                645                 650                 655     


Leu Leu Arg Gly Ala Asn Gly Val Ala Tyr Ser Ser Leu Pro Asp Asn 
            660                 665                 670         


Ala Ile Tyr His Phe Cys Lys Gln Ala Lys Lys Cys Gly Val Asp Ile 
        675                 680                 685             


Phe Arg Val Phe Asp Ala Leu Asn Asp Val Asp Gln Leu Glu Val Gly 
    690                 695                 700                 


Ile Lys Ala Val His Ala Ala Glu Gly Val Val Glu Ala Thr Ile Cys 
705                 710                 715                 720 


Tyr Ser Gly Asp Met Leu Asn Pro Ser Lys Lys Tyr Asn Leu Pro Tyr 
                725                 730                 735     


Tyr Leu Asp Leu Val Asp Lys Val Val Gln Phe Lys Pro His Val Leu 
            740                 745                 750         


Gly Ile Lys Asp Met Ala Gly Val Leu Lys Pro Gln Ala Ala Arg Leu 
        755                 760                 765             


Leu Ile Gly Ser Ile Arg Glu Arg Tyr Pro Asp Leu Pro Ile His Val 
    770                 775                 780                 


His Thr His Asp Ser Ala Gly Thr Gly Val Ala Ser Met Ile Ala Cys 
785                 790                 795                 800 


Ala Gln Ala Gly Ala Asp Ala Val Asp Ala Ala Thr Asp Ser Leu Ser 
                805                 810                 815     


Gly Met Thr Ser Gln Pro Ser Ile Gly Ala Ile Leu Ala Ser Leu Glu 
            820                 825                 830         


Gly Thr Glu His Asp Pro Gly Leu Asn Ser Ala Gln Val Arg Ala Leu 
        835                 840                 845             


Asp Thr Tyr Trp Ala Gln Leu Arg Leu Leu Tyr Ser Pro Phe Glu Ala 
    850                 855                 860                 


Gly Leu Thr Gly Pro Asp Pro Glu Val Tyr Glu His Glu Ile Pro Gly 
865                 870                 875                 880 


Gly Gln Leu Thr Asn Leu Ile Phe Gln Ala Ser Gln Leu Gly Leu Gly 
                885                 890                 895     


Gln Gln Trp Ala Glu Thr Lys Lys Ala Tyr Glu Ser Ala Asn Asp Leu 
            900                 905                 910         


Leu Gly Asp Val Val Lys Val Thr Pro Thr Ser Lys Val Val Gly Asp 
        915                 920                 925             


Leu Ala Gln Phe Met Val Ser Asn Lys Leu Thr Ala Glu Asp Val Ile 
    930                 935                 940                 


Ala Arg Ala Gly Glu Leu Asp Phe Pro Gly Ser Val Leu Glu Phe Leu 
945                 950                 955                 960 


Glu Gly Leu Met Gly Gln Pro Tyr Gly Gly Phe Pro Glu Pro Leu Arg 
                965                 970                 975     


Ser Arg Ala Leu Arg Asp Arg Arg Lys Leu Asp Lys Arg Pro Gly Leu 
            980                 985                 990         


Tyr Leu Glu Pro Leu Asp Leu Ala  Lys Ile Lys Ser Gln  Ile Arg Glu 
        995                 1000                 1005             


Asn Tyr  Gly Ala Ala Thr Glu  Tyr Asp Val Ala Ser  Tyr Ala Met 
    1010                 1015                 1020             


Tyr Pro  Lys Val Phe Glu Asp  Tyr Lys Lys Phe Val  Ala Lys Phe 
    1025                 1030                 1035             


Gly Asp  Leu Ser Val Leu Pro  Thr Arg Tyr Phe Leu  Ala Lys Pro 
    1040                 1045                 1050             


Glu Ile  Gly Glu Glu Phe His  Val Glu Leu Glu Lys  Gly Lys Val 
    1055                 1060                 1065             


Leu Ile  Leu Lys Leu Leu Ala  Ile Gly Pro Leu Ser  Glu Gln Thr 
    1070                 1075                 1080             


Gly Gln  Arg Glu Val Phe Tyr  Glu Val Asn Gly Glu  Val Arg Gln 
    1085                 1090                 1095             


Val Ser  Val Asp Asp Lys Lys  Ala Ser Val Glu Asn  Thr Ala Arg 
    1100                 1105                 1110             


Pro Lys  Ala Glu Leu Gly Asp  Ser Ser Gln Val Gly  Ala Pro Met 
    1115                 1120                 1125             


Ser Gly  Val Val Val Glu Ile  Arg Val His Asp Gly  Leu Glu Val 
    1130                 1135                 1140             


Lys Lys  Gly Asp Pro Ile Ala  Val Leu Ser Ala Met  Lys Met Glu 
    1145                 1150                 1155             


Met Val  Ile Ser Ala Pro His  Ser Gly Lys Val Ser  Ser Leu Leu 
    1160                 1165                 1170             


Val Lys  Glu Gly Asp Ser Val  Asp Gly Gln Asp Leu  Val Cys Lys 
    1175                 1180                 1185             


Ile Val  Lys Ala 
    1190         


<210>  7
<211>  3579
<212>  DNA
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  7
atgcatgcgc cacgccagcc cgaggaggcc gtcgatgata ccgagttcat tgatgaccat     60

catgatcagc atcgcgatag tgtccatacc cgtctgcgag ccaatagtgc aattatgcaa    120

ttccagaaaa tactggtagc taacagggga gaaattccga tccgtatctt ccgcacagct    180

cacgaactgt cgctgcagac tgtcgcggta tactcacacg aggacagact ctctatgcac    240

cgccaaaagg cagatgaggc ttatatgata ggcaagcgcg gtcagtacac ccccgtgggc    300

gcatatcttg caatcgatga aatcgtaaag atcgcattgg agcacggtgt gcacctgatt    360

caccctggtt acggtttcct gtctgagaac gcagagtttg ctaggaaagt tgagcagtcc    420

ggcatggtgt tcgttgggcc tacgccccaa acgatagaga gcctcggaga caaagtgagt    480

gcaaggcaac tggccatccg ttgcgacgtc cccgtggtcc ccggaacacc aggtcctgtc    540

gaacgatacg aggaggtaaa ggcgtttaca gatacctacg ggttccccat cattatcaag    600

gcggcatttg gcggaggcgg acgtggaatg cgagttgtga gggaccaggc tgaattgaga    660

gacagtttcg aacgggcaac aagtgaagcc aggtctgcgt ttgggaatgg cacagttttc    720

gtggagcgat tcctcgatcg acctaagcac atcgaagtac aactccttgg ggacaaccac    780

ggtaatgtgg tccacctttt tgagcgtgac tgtagcgtcc agcgcagaca ccagaaggtg    840

gttgagatag ctccagcaaa ggacttgcca gcagacgtgc gtgaccgcat actcgctgat    900

gcggtgaagc tcgccaaatc ggtgaattac cggaacgccg gtactgccga gttcctggtc    960

gatcagcaga accgatacta ctttatcgag atcaatcccc gcatacaggt cgagcatacg   1020

attaccgagg aaattactgg catcgacatc gtcgcagccc agattcagat cgcggcaggg   1080

gccacccttg agcaacttgg actgacacag gaccgcattt caacacgggg ctttgcgatc   1140

cagtgtagga tcaccacaga ggaccctagc aagggatttt ccccagatac cggcaagatc   1200

gaagtctacc gtagtgccgg aggcaatggt gtgaggctgg atggcggtaa tggttttgca   1260

ggcgcgatta tcacgcccca ttacgacagc atgttggtca aatgcacgtg tcgtggtagt   1320

acttacgaga tcgctaggcg aaaagtggtc cgagcgttgg tcgagttccg catccgtgga   1380

gtgaaaacta acattccgtt ccttaccagc ctcctgagtc atcccgtttt cgtcgatggg   1440

acttgctgga ccacgttcat agacgacacc ccggagcttt tcgcactcgt tggatctcaa   1500

aacagggccc aaaaactgct ggcttacctc ggtgacgtcg ccgtgaacgg ttcctccatc   1560

aaggggcaga tcggagagcc taagctgaaa ggcgatatca tcaagcctgt ccttcatgac   1620

gccgctggga agccgctgga tgtctccgtt cccgcgacga agggctggaa gcaaatattg   1680

gactcggaag gccctgaggc tttcgccagg gctgtgaggg cgaataaggg ctgtctgatt   1740

atggatacca catggcgcga cgctcatcaa agtctgcttg ctactcgcgt ccgtaccatc   1800

gacctcctga acatcgcgca tgaaacatcc catgctctcg cgaatgccta cagtctggaa   1860

tgttggggag gggctacctt tgacgtggcc atgagattcc tctacgaaga tccctgggat   1920

agacttagga agttgcgaaa ggctgtaccg aatatcccat tccaaatgct gctgcgcgga   1980

gcgaacgggg ttgcttactc tagcttgccc gataatgcaa tctaccattt ctgcaagcag   2040

gcaaagaagt gcggcgtcga tattttccgg gtgttcgacg cgttgaatga tgtggatcag   2100

ttggaagtgg gtattaaggc ggtacacgcc gctgaaggcg tcgtcgaagc gaccatttgc   2160

tattccgggg atatgttgaa cccttccaaa aagtacaatc tcccatatta tctcgacctc   2220

gtagataagg tcgttcagtt caagccccac gtgttgggca ttaaggatat ggcaggggtg   2280

ttgaaaccac aagcagcccg gttgctcatc gggtccatcc gagagcgcta cccagacctc   2340

ccaatccacg tgcacaccca tgatagcgct ggcaccggtg tcgcttcaat gatcgcgtgc   2400

gcccaggctg gtgccgatgc tgtggacgca gccactgact ccctctcggg tatgacctcc   2460

cagccctcaa taggtgcgat tctcgcctct ctcgaaggca ctgaacatga ccccggattg   2520

aatagcgccc aagttcgtgc attggacaca tattgggcgc agctccgctt gttgtattcc   2580

ccattcgagg ctgggcttac cggaccggac cccgaagtct atgagcacga aatcccaggc   2640

ggtcaactca ccaacctcat ttttcaggcc tctcagctcg gcctgggcca gcagtgggcc   2700

gagactaaaa aggcttatga gagtgccaac gaccttctgg gagatgtggt taaggtgacg   2760

ccgacgtcca aggtcgtggg cgacctggcg cagtttatgg tttcgaacaa acttaccgcc   2820

gaagatgtga tcgcccgagc aggagaattg gacttccctg gcagtgtcct ggaatttctg   2880

gagggactga tgggtcaacc ttatggtgga ttcccggaac ctttgcggtc gcgtgccttg   2940

cgggatcggc ggaagctcga caaaaggcct gggctttacc ttgagcctct tgatctcgcg   3000

aaaatcaaat ctcaaattcg tgagaactac ggtgccgcca cggaatacga tgtcgctagt   3060

tatgcaatgt atccgaaagt tttcgaagat tacaaaaagt tcgtcgcgaa gtttggcgat   3120

ctgtccgttc tcccgacacg gtattttctc gccaaacccg agatcggcga ggagtttcac   3180

gtcgagctgg agaagggtaa ggtgttgatt ctgaagctgt tggcaattgg ccctcttagc   3240

gaacagactg ggcagcgaga agtgttctat gaggtcaacg gcgaagttcg acaagtgtcg   3300

gtagacgaca aaaaggcgtc cgtggagaac actgctcgcc cgaaggctga gctgggtgac   3360

agtagtcaag tcggcgctcc tatgtctgga gttgtcgtag aaattcgcgt tcacgatgga   3420

ttggaagtga aaaagggaga tccgattgcg gtactgtcag ctatgaaaat ggagatggtt   3480

atttctgccc cacattccgg aaaggtttcg agcctccttg tcaaagaggg cgacagtgta   3540

gacggtcagg atttggtctg caagatcgtg aaagcctga                          3579


<210>  8
<211>  1192
<212>  PRT
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  8

Met His Ala Pro Arg Gln Pro Glu Glu Ala Val Asp Asp Thr Glu Phe 
1               5                   10                  15      


Ile Asp Asp His His Asp Gln His Arg Asp Ser Val His Thr Arg Leu 
            20                  25                  30          


Arg Ala Asn Ser Ala Ile Met Gln Phe Gln Lys Ile Leu Val Ala Asn 
        35                  40                  45              


Arg Gly Glu Ile Pro Ile Arg Ile Phe Arg Thr Ala His Glu Leu Ser 
    50                  55                  60                  


Leu Gln Thr Val Ala Val Tyr Ser His Glu Asp Arg Leu Ser Met His 
65                  70                  75                  80  


Arg Gln Lys Ala Asp Glu Ala Tyr Met Ile Gly Lys Arg Gly Gln Tyr 
                85                  90                  95      


Thr Pro Val Gly Ala Tyr Leu Ala Ile Asp Glu Ile Val Lys Ile Ala 
            100                 105                 110         


Leu Glu His Gly Val His Leu Ile His Pro Gly Tyr Gly Phe Leu Ser 
        115                 120                 125             


Glu Asn Ala Glu Phe Ala Arg Lys Val Glu Gln Ser Gly Met Val Phe 
    130                 135                 140                 


Val Gly Pro Thr Pro Gln Thr Ile Glu Ser Leu Gly Asp Lys Val Ser 
145                 150                 155                 160 


Ala Arg Gln Leu Ala Ile Arg Cys Asp Val Pro Val Val Pro Gly Thr 
                165                 170                 175     


Pro Gly Pro Val Glu Arg Tyr Glu Glu Val Lys Ala Phe Thr Asp Thr 
            180                 185                 190         


Tyr Gly Phe Pro Ile Ile Ile Lys Ala Ala Phe Gly Gly Gly Gly Arg 
        195                 200                 205             


Gly Met Arg Val Val Arg Asp Gln Ala Glu Leu Arg Asp Ser Phe Glu 
    210                 215                 220                 


Arg Ala Thr Ser Glu Ala Arg Ser Ala Phe Gly Asn Gly Thr Val Phe 
225                 230                 235                 240 


Val Glu Arg Phe Leu Asp Arg Pro Lys His Ile Glu Val Gln Leu Leu 
                245                 250                 255     


Gly Asp Asn His Gly Asn Val Val His Leu Phe Glu Arg Asp Cys Ser 
            260                 265                 270         


Val Gln Arg Arg His Gln Lys Val Val Glu Ile Ala Pro Ala Lys Asp 
        275                 280                 285             


Leu Pro Ala Asp Val Arg Asp Arg Ile Leu Ala Asp Ala Val Lys Leu 
    290                 295                 300                 


Ala Lys Ser Val Asn Tyr Arg Asn Ala Gly Thr Ala Glu Phe Leu Val 
305                 310                 315                 320 


Asp Gln Gln Asn Arg Tyr Tyr Phe Ile Glu Ile Asn Pro Arg Ile Gln 
                325                 330                 335     


Val Glu His Thr Ile Thr Glu Glu Ile Thr Gly Ile Asp Ile Val Ala 
            340                 345                 350         


Ala Gln Ile Gln Ile Ala Ala Gly Ala Thr Leu Glu Gln Leu Gly Leu 
        355                 360                 365             


Thr Gln Asp Arg Ile Ser Thr Arg Gly Phe Ala Ile Gln Cys Arg Ile 
    370                 375                 380                 


Thr Thr Glu Asp Pro Ser Lys Gly Phe Ser Pro Asp Thr Gly Lys Ile 
385                 390                 395                 400 


Glu Val Tyr Arg Ser Ala Gly Gly Asn Gly Val Arg Leu Asp Gly Gly 
                405                 410                 415     


Asn Gly Phe Ala Gly Ala Ile Ile Thr Pro His Tyr Asp Ser Met Leu 
            420                 425                 430         


Val Lys Cys Thr Cys Arg Gly Ser Thr Tyr Glu Ile Ala Arg Arg Lys 
        435                 440                 445             


Val Val Arg Ala Leu Val Glu Phe Arg Ile Arg Gly Val Lys Thr Asn 
    450                 455                 460                 


Ile Pro Phe Leu Thr Ser Leu Leu Ser His Pro Val Phe Val Asp Gly 
465                 470                 475                 480 


Thr Cys Trp Thr Thr Phe Ile Asp Asp Thr Pro Glu Leu Phe Ala Leu 
                485                 490                 495     


Val Gly Ser Gln Asn Arg Ala Gln Lys Leu Leu Ala Tyr Leu Gly Asp 
            500                 505                 510         


Val Ala Val Asn Gly Ser Ser Ile Lys Gly Gln Ile Gly Glu Pro Lys 
        515                 520                 525             


Leu Lys Gly Asp Ile Ile Lys Pro Val Leu His Asp Ala Ala Gly Lys 
    530                 535                 540                 


Pro Leu Asp Val Ser Val Pro Ala Thr Lys Gly Trp Lys Gln Ile Leu 
545                 550                 555                 560 


Asp Ser Glu Gly Pro Glu Ala Phe Ala Arg Ala Val Arg Ala Asn Lys 
                565                 570                 575     


Gly Cys Leu Ile Met Asp Thr Thr Trp Arg Asp Ala His Gln Ser Leu 
            580                 585                 590         


Leu Ala Thr Arg Val Arg Thr Ile Asp Leu Leu Asn Ile Ala His Glu 
        595                 600                 605             


Thr Ser His Ala Leu Ala Asn Ala Tyr Ser Leu Glu Cys Trp Gly Gly 
    610                 615                 620                 


Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Asp Pro Trp Asp 
625                 630                 635                 640 


Arg Leu Arg Lys Leu Arg Lys Ala Val Pro Asn Ile Pro Phe Gln Met 
                645                 650                 655     


Leu Leu Arg Gly Ala Asn Gly Val Ala Tyr Ser Ser Leu Pro Asp Asn 
            660                 665                 670         


Ala Ile Tyr His Phe Cys Lys Gln Ala Lys Lys Cys Gly Val Asp Ile 
        675                 680                 685             


Phe Arg Val Phe Asp Ala Leu Asn Asp Val Asp Gln Leu Glu Val Gly 
    690                 695                 700                 


Ile Lys Ala Val His Ala Ala Glu Gly Val Val Glu Ala Thr Ile Cys 
705                 710                 715                 720 


Tyr Ser Gly Asp Met Leu Asn Pro Ser Lys Lys Tyr Asn Leu Pro Tyr 
                725                 730                 735     


Tyr Leu Asp Leu Val Asp Lys Val Val Gln Phe Lys Pro His Val Leu 
            740                 745                 750         


Gly Ile Lys Asp Met Ala Gly Val Leu Lys Pro Gln Ala Ala Arg Leu 
        755                 760                 765             


Leu Ile Gly Ser Ile Arg Glu Arg Tyr Pro Asp Leu Pro Ile His Val 
    770                 775                 780                 


His Thr His Asp Ser Ala Gly Thr Gly Val Ala Ser Met Ile Ala Cys 
785                 790                 795                 800 


Ala Gln Ala Gly Ala Asp Ala Val Asp Ala Ala Thr Asp Ser Leu Ser 
                805                 810                 815     


Gly Met Thr Ser Gln Pro Ser Ile Gly Ala Ile Leu Ala Ser Leu Glu 
            820                 825                 830         


Gly Thr Glu His Asp Pro Gly Leu Asn Ser Ala Gln Val Arg Ala Leu 
        835                 840                 845             


Asp Thr Tyr Trp Ala Gln Leu Arg Leu Leu Tyr Ser Pro Phe Glu Ala 
    850                 855                 860                 


Gly Leu Thr Gly Pro Asp Pro Glu Val Tyr Glu His Glu Ile Pro Gly 
865                 870                 875                 880 


Gly Gln Leu Thr Asn Leu Ile Phe Gln Ala Ser Gln Leu Gly Leu Gly 
                885                 890                 895     


Gln Gln Trp Ala Glu Thr Lys Lys Ala Tyr Glu Ser Ala Asn Asp Leu 
            900                 905                 910         


Leu Gly Asp Val Val Lys Val Thr Pro Thr Ser Lys Val Val Gly Asp 
        915                 920                 925             


Leu Ala Gln Phe Met Val Ser Asn Lys Leu Thr Ala Glu Asp Val Ile 
    930                 935                 940                 


Ala Arg Ala Gly Glu Leu Asp Phe Pro Gly Ser Val Leu Glu Phe Leu 
945                 950                 955                 960 


Glu Gly Leu Met Gly Gln Pro Tyr Gly Gly Phe Pro Glu Pro Leu Arg 
                965                 970                 975     


Ser Arg Ala Leu Arg Asp Arg Arg Lys Leu Asp Lys Arg Pro Gly Leu 
            980                 985                 990         


Tyr Leu Glu Pro Leu Asp Leu Ala  Lys Ile Lys Ser Gln  Ile Arg Glu 
        995                 1000                 1005             


Asn Tyr  Gly Ala Ala Thr Glu  Tyr Asp Val Ala Ser  Tyr Ala Met 
    1010                 1015                 1020             


Tyr Pro  Lys Val Phe Glu Asp  Tyr Lys Lys Phe Val  Ala Lys Phe 
    1025                 1030                 1035             


Gly Asp  Leu Ser Val Leu Pro  Thr Arg Tyr Phe Leu  Ala Lys Pro 
    1040                 1045                 1050             


Glu Ile  Gly Glu Glu Phe His  Val Glu Leu Glu Lys  Gly Lys Val 
    1055                 1060                 1065             


Leu Ile  Leu Lys Leu Leu Ala  Ile Gly Pro Leu Ser  Glu Gln Thr 
    1070                 1075                 1080             


Gly Gln  Arg Glu Val Phe Tyr  Glu Val Asn Gly Glu  Val Arg Gln 
    1085                 1090                 1095             


Val Ser  Val Asp Asp Lys Lys  Ala Ser Val Glu Asn  Thr Ala Arg 
    1100                 1105                 1110             


Pro Lys  Ala Glu Leu Gly Asp  Ser Ser Gln Val Gly  Ala Pro Met 
    1115                 1120                 1125             


Ser Gly  Val Val Val Glu Ile  Arg Val His Asp Gly  Leu Glu Val 
    1130                 1135                 1140             


Lys Lys  Gly Asp Pro Ile Ala  Val Leu Ser Ala Met  Lys Met Glu 
    1145                 1150                 1155             


Met Val  Ile Ser Ala Pro His  Ser Gly Lys Val Ser  Ser Leu Leu 
    1160                 1165                 1170             


Val Lys  Glu Gly Asp Ser Val  Asp Gly Gln Asp Leu  Val Cys Lys 
    1175                 1180                 1185             


Ile Val  Lys Ala 
    1190         


<210>  9
<211>  1350
<212>  DNA
<213>  Artificial

<220>
<223>  Modified from Aspergillus niger sequence

<400>  9
atggctcccc cccaagctcc cgtgcaaccg cccaagagac gccgcatcgg tgtcttgacc     60

tctggtggcg atgctcccgg tatgaacggt gtcgtccggg ccgtcgtccg gatggctatc    120

cactccgact gtgaggcttt cgccgtctac gaaggttacg agggtctcgt caatggcggc    180

gacatgatcc gtcagcttca ctgggaggat gttcgcggct ggttgtcccg tggtggtacc    240

ttgatcggtt ccgcccgctg catgaccttc cgtgagcgcc ccggtcgtct gcgggctgcc    300

aagaacatgg tcctccgtgg cattgacgcc cttgtcgtct gtggtggtga tggcagtttg    360

actggtgccg acgtttttcg ttccgagtgg cccggtctgt tgaaggaatt ggtcgagacg    420

ggcgagttga ccgaagagca ggtcaagcca taccagattc tgaacatcgt cggtttggtg    480

ggttcgatcg ataacgacat gtccggcacc gacgccacca tcggttgcta ctcctccctc    540

actcgcatct gtgacgccgt cgacgacgtc ttcgatactg ccttttccca ccagcgtgga    600

ttcgtcattg aggtcatggg tcgtcactgc ggttggctgg ccttgatgtc tgctatcagt    660

accggtgccg actggctgtt cgtgcccgag atgccgccca aggacggatg ggaggatgac    720

atgtgcgcta tcattaccaa gaacagaaag gagcgtggaa agcgtaggac gatcgtcatc    780

gtggccgagg gtgcccagga tcgccatctc aacaagatct cgagttcgaa gatcaaggat    840

attttgacgg agcggttgaa cctggatacc cgtgtgactg tgttgggtca cactcagaga    900

ggtggagccg cctgtgcgta cgaccgctgg ctgtccacac tgcagggtgt cgaggctgtc    960

cgcgcggtgc tggacatgaa gcccgaagcc ccgtccccgg tcatcaccat ccgtgagaac   1020

aagatcttgc gcatgccgtt gatggacgcc gtgcagcaca ccaagactgt caccaagcac   1080

attcagaaca aggagttcgc cgaagccatg gccctccgcg actcggaatt caaagagtac   1140

cacttttcct acatcaacac ttccacgccc gaccacccga agctgctcct cccagagaac   1200

aagagaatgc gcatcggtat tattcacgtt ggcgcccccg ctggtggtat gaaccaggct   1260

acccgcgcgg ccgttgccta ctgcctgact cgtggccaca cccccctggc cattcacaac   1320

ggtttccccg gtctgtgccg gcactatgat                                    1350


<210>  10
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  Modified from Aspergillus niger sequence

<400>  10

Met Ala Pro Pro Gln Ala Pro Val Gln Pro Pro Lys Arg Arg Arg Ile 
1               5                   10                  15      


Gly Val Leu Thr Ser Gly Gly Asp Ala Pro Gly Met Asn Gly Val Val 
            20                  25                  30          


Arg Ala Val Val Arg Met Ala Ile His Ser Asp Cys Glu Ala Phe Ala 
        35                  40                  45              


Val Tyr Glu Gly Tyr Glu Gly Leu Val Asn Gly Gly Asp Met Ile Arg 
    50                  55                  60                  


Gln Leu His Trp Glu Asp Val Arg Gly Trp Leu Ser Arg Gly Gly Thr 
65                  70                  75                  80  


Leu Ile Gly Ser Ala Arg Cys Met Thr Phe Arg Glu Arg Pro Gly Arg 
                85                  90                  95      


Leu Arg Ala Ala Lys Asn Met Val Leu Arg Gly Ile Asp Ala Leu Val 
            100                 105                 110         


Val Cys Gly Gly Asp Gly Ser Leu Thr Gly Ala Asp Val Phe Arg Ser 
        115                 120                 125             


Glu Trp Pro Gly Leu Leu Lys Glu Leu Val Glu Thr Gly Glu Leu Thr 
    130                 135                 140                 


Glu Glu Gln Val Lys Pro Tyr Gln Ile Leu Asn Ile Val Gly Leu Val 
145                 150                 155                 160 


Gly Ser Ile Asp Asn Asp Met Ser Gly Thr Asp Ala Thr Ile Gly Cys 
                165                 170                 175     


Tyr Ser Ser Leu Thr Arg Ile Cys Asp Ala Val Asp Asp Val Phe Asp 
            180                 185                 190         


Thr Ala Phe Ser His Gln Arg Gly Phe Val Ile Glu Val Met Gly Arg 
        195                 200                 205             


His Cys Gly Trp Leu Ala Leu Met Ser Ala Ile Ser Thr Gly Ala Asp 
    210                 215                 220                 


Trp Leu Phe Val Pro Glu Met Pro Pro Lys Asp Gly Trp Glu Asp Asp 
225                 230                 235                 240 


Met Cys Ala Ile Ile Thr Lys Asn Arg Lys Glu Arg Gly Lys Arg Arg 
                245                 250                 255     


Thr Ile Val Ile Val Ala Glu Gly Ala Gln Asp Arg His Leu Asn Lys 
            260                 265                 270         


Ile Ser Ser Ser Lys Ile Lys Asp Ile Leu Thr Glu Arg Leu Asn Leu 
        275                 280                 285             


Asp Thr Arg Val Thr Val Leu Gly His Thr Gln Arg Gly Gly Ala Ala 
    290                 295                 300                 


Cys Ala Tyr Asp Arg Trp Leu Ser Thr Leu Gln Gly Val Glu Ala Val 
305                 310                 315                 320 


Arg Ala Val Leu Asp Met Lys Pro Glu Ala Pro Ser Pro Val Ile Thr 
                325                 330                 335     


Ile Arg Glu Asn Lys Ile Leu Arg Met Pro Leu Met Asp Ala Val Gln 
            340                 345                 350         


His Thr Lys Thr Val Thr Lys His Ile Gln Asn Lys Glu Phe Ala Glu 
        355                 360                 365             


Ala Met Ala Leu Arg Asp Ser Glu Phe Lys Glu Tyr His Phe Ser Tyr 
    370                 375                 380                 


Ile Asn Thr Ser Thr Pro Asp His Pro Lys Leu Leu Leu Pro Glu Asn 
385                 390                 395                 400 


Lys Arg Met Arg Ile Gly Ile Ile His Val Gly Ala Pro Ala Gly Gly 
                405                 410                 415     


Met Asn Gln Ala Thr Arg Ala Ala Val Ala Tyr Cys Leu Thr Arg Gly 
            420                 425                 430         


His Thr Pro Leu Ala Ile His Asn Gly Phe Pro Gly Leu Cys Arg His 
        435                 440                 445             


Tyr Asp 
    450 


<210>  11
<211>  1014
<212>  DNA
<213>  Rhizopus oryzae

<400>  11
atgtttgctg cctctcgtgt tttctctatt gctgccaagc gttctttctc tacttctgct     60

gctaatcttt ccaaggttgc cgttcttggc gctgctggtg gtattggtca acccttgtct    120

ttgttgttga aggaaaaccc tcacgtcacc cacctttctc tttatgatat tgtcaacact    180

cctggtgtcg ctgccgatct tagccacatc aacaccaact ccaaggtcac tggccacacc    240

cctgaaaacg atggtttgaa gactgctctt gaaggtgctc acgttgttgt tattcctgct    300

ggcgttcctc gtaagcctgg tatgacccgt gatgatttat tcaacaccaa tgcttccatt    360

gttcgtgacc ttgctgaagc tgctgccaag cactgtcccg acgctcattt ccttatcatc    420

tccaaccctg tcaactccac tgttcccatc tttgccgaaa ccttaaagaa ggctggtgtc    480

ttcaacccta agcgtttgta tggtgtcacc actcttgatg tcgtccgtgc ctctcgcttc    540

gttgccgaag tcaagaactt ggaccccaac gatgtcaagg ttaccgttgt cggtggtcac    600

tctggtgtga ctattgtccc tctcctctct caaaccggtc tcgaattcag caaggaagaa    660

ctcgatgcct tgacccaccg tatccaattc ggtggtgatg aagtcgttca agccaagaat    720

ggtactggtt ctgccactct ctccatggcc tttgccggtg ctcgtttcgc caactctgtc    780

ttggaagcca ctgttggtgg taagaagggt gttgttgaac cctcctttgt caagtctgat    840

gtctttgcca aggatggtgt tgaatatttc tctaccaaca ttgaacttgg tcctgaaggt    900

gttgaaaaga tcaacgaact cggtcaaatc tctgactatg aaaaggaact tattgctaag    960

gccgttcctg aattaaagaa gaacattgct aagggtaaca gctttgttca ataa         1014


<210>  12
<211>  337
<212>  PRT
<213>  Rhizopus oryzae

<400>  12

Met Phe Ala Ala Ser Arg Val Phe Ser Ile Ala Ala Lys Arg Ser Phe 
1               5                   10                  15      


Ser Thr Ser Ala Ala Asn Leu Ser Lys Val Ala Val Leu Gly Ala Ala 
            20                  25                  30          


Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Glu Asn Pro His 
        35                  40                  45              


Val Thr His Leu Ser Leu Tyr Asp Ile Val Asn Thr Pro Gly Val Ala 
    50                  55                  60                  


Ala Asp Leu Ser His Ile Asn Thr Asn Ser Lys Val Thr Gly His Thr 
65                  70                  75                  80  


Pro Glu Asn Asp Gly Leu Lys Thr Ala Leu Glu Gly Ala His Val Val 
                85                  90                  95      


Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp 
            100                 105                 110         


Leu Phe Asn Thr Asn Ala Ser Ile Val Arg Asp Leu Ala Glu Ala Ala 
        115                 120                 125             


Ala Lys His Cys Pro Asp Ala His Phe Leu Ile Ile Ser Asn Pro Val 
    130                 135                 140                 


Asn Ser Thr Val Pro Ile Phe Ala Glu Thr Leu Lys Lys Ala Gly Val 
145                 150                 155                 160 


Phe Asn Pro Lys Arg Leu Tyr Gly Val Thr Thr Leu Asp Val Val Arg 
                165                 170                 175     


Ala Ser Arg Phe Val Ala Glu Val Lys Asn Leu Asp Pro Asn Asp Val 
            180                 185                 190         


Lys Val Thr Val Val Gly Gly His Ser Gly Val Thr Ile Val Pro Leu 
        195                 200                 205             


Leu Ser Gln Thr Gly Leu Glu Phe Ser Lys Glu Glu Leu Asp Ala Leu 
    210                 215                 220                 


Thr His Arg Ile Gln Phe Gly Gly Asp Glu Val Val Gln Ala Lys Asn 
225                 230                 235                 240 


Gly Thr Gly Ser Ala Thr Leu Ser Met Ala Phe Ala Gly Ala Arg Phe 
                245                 250                 255     


Ala Asn Ser Val Leu Glu Ala Thr Val Gly Gly Lys Lys Gly Val Val 
            260                 265                 270         


Glu Pro Ser Phe Val Lys Ser Asp Val Phe Ala Lys Asp Gly Val Glu 
        275                 280                 285             


Tyr Phe Ser Thr Asn Ile Glu Leu Gly Pro Glu Gly Val Glu Lys Ile 
    290                 295                 300                 


Asn Glu Leu Gly Gln Ile Ser Asp Tyr Glu Lys Glu Leu Ile Ala Lys 
305                 310                 315                 320 


Ala Val Pro Glu Leu Lys Lys Asn Ile Ala Lys Gly Asn Ser Phe Val 
                325                 330                 335     


Gln 
    


<210>  13
<211>  1014
<212>  DNA
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  13
atgcatgcgg cctctcgggt gttctctatt gcagcaaagc gttctttctc aacgagtgct     60

gcgaatcttt ccaaagttgc cgttctgggc gcggctggcg gaattggcca gcccttgagt    120

ttgctgctaa aggagaatcc acatgtcacc cacctttcac tttacgatat tgtgaacact    180

ccgggagtcg ctgcagacct aagccatata aataccaaca gcaaggtcac tggccacacc    240

cccgagaatg atggtctcaa gacagcactg gaaggggctc acgttgtggt tataccggct    300

ggcgtgccta ggaaacctgg catgacgcga gatgatttat tcaacaccaa tgcgtccata    360

gtacgtgacc tggcagaggc tgctgccaaa cactgccccg acgcacattt ccttatcatc    420

tccaaccctg tcaactccac tgtgcccatc tttgccgaga ccttaaagaa ggctggtgta    480

ttcaacccta agagattgta tggcgtgacg acgcttgacg tggtccgggc ctcacgcttc    540

gtggccgagg tcaagaactt ggaccccaac gatgtcaaag tgaccgttgt cgggggtcat    600

tcgggcgtga caatcgtccc actcctctcg cagaccgggc tcgaattcag caaggaggaa    660

ctagatgcgt tgacgcaccg catccaattc ggaggtgacg aggtcgtaca ggccaaaaat    720

gggactggtt cggtcactct cagtatggcc tttgcgggcg ctcgattcgc caactccgtg    780

cttgaggcca cagtgggagg aaaaaagggt gttgttgaac cgtcctttgt gaagtctgat    840

gtgtttgcta aagatggggt tgaatacttc agcacaaata tcgagctggg accggaaggt    900

gtggagaaga tcaatgaact cggacaaatc tcggactatg agaaggaact gattgctaag    960

gccgtaccag aactgaagaa gaacattgcg aaaggaaaca gctttgttca gtaa         1014


<210>  14
<211>  337
<212>  PRT
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  14

Met His Ala Ala Ser Arg Val Phe Ser Ile Ala Ala Lys Arg Ser Phe 
1               5                   10                  15      


Ser Thr Ser Ala Ala Asn Leu Ser Lys Val Ala Val Leu Gly Ala Ala 
            20                  25                  30          


Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Glu Asn Pro His 
        35                  40                  45              


Val Thr His Leu Ser Leu Tyr Asp Ile Val Asn Thr Pro Gly Val Ala 
    50                  55                  60                  


Ala Asp Leu Ser His Ile Asn Thr Asn Ser Lys Val Thr Gly His Thr 
65                  70                  75                  80  


Pro Glu Asn Asp Gly Leu Lys Thr Ala Leu Glu Gly Ala His Val Val 
                85                  90                  95      


Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp 
            100                 105                 110         


Leu Phe Asn Thr Asn Ala Ser Ile Val Arg Asp Leu Ala Glu Ala Ala 
        115                 120                 125             


Ala Lys His Cys Pro Asp Ala His Phe Leu Ile Ile Ser Asn Pro Val 
    130                 135                 140                 


Asn Ser Thr Val Pro Ile Phe Ala Glu Thr Leu Lys Lys Ala Gly Val 
145                 150                 155                 160 


Phe Asn Pro Lys Arg Leu Tyr Gly Val Thr Thr Leu Asp Val Val Arg 
                165                 170                 175     


Ala Ser Arg Phe Val Ala Glu Val Lys Asn Leu Asp Pro Asn Asp Val 
            180                 185                 190         


Lys Val Thr Val Val Gly Gly His Ser Gly Val Thr Ile Val Pro Leu 
        195                 200                 205             


Leu Ser Gln Thr Gly Leu Glu Phe Ser Lys Glu Glu Leu Asp Ala Leu 
    210                 215                 220                 


Thr His Arg Ile Gln Phe Gly Gly Asp Glu Val Val Gln Ala Lys Asn 
225                 230                 235                 240 


Gly Thr Gly Ser Val Thr Leu Ser Met Ala Phe Ala Gly Ala Arg Phe 
                245                 250                 255     


Ala Asn Ser Val Leu Glu Ala Thr Val Gly Gly Lys Lys Gly Val Val 
            260                 265                 270         


Glu Pro Ser Phe Val Lys Ser Asp Val Phe Ala Lys Asp Gly Val Glu 
        275                 280                 285             


Tyr Phe Ser Thr Asn Ile Glu Leu Gly Pro Glu Gly Val Glu Lys Ile 
    290                 295                 300                 


Asn Glu Leu Gly Gln Ile Ser Asp Tyr Glu Lys Glu Leu Ile Ala Lys 
305                 310                 315                 320 


Ala Val Pro Glu Leu Lys Lys Asn Ile Ala Lys Gly Asn Ser Phe Val 
                325                 330                 335     


Gln 
    


<210>  15
<211>  1473
<212>  DNA
<213>  Aspergillus terreus

<400>  15
atgaccaagc aatctgcgga cagcaacgca aagtcaggag ttacggccga aatatgccat     60

tgggcatcca acctggccac tgacgacatc ccttcggacg tattagaaag agcgaaatac    120

ctgattctcg atggtattgc atgtgcctgg gttggtgcaa gagtgccttg gtcagagaag    180

tatgtgcagg caacaatgag ctttgagccg ccaggagcct gcagggtgat tggatatggg    240

cagaaactgg ggcctgttgc agcagccatg accaattccg ctttcataca ggccacagag    300

cttgacgact accacagcga agccccccta cactctgcaa gcatcgtcct ccctgcggtc    360

tttgcagcaa gtgaggtctt agccgagcaa ggcaaaacaa tttctggtat agatgtcatt    420

ctagccgcca ttgtggggtt tgaatctggc ccgcggatcg gcaaagcaat ttacggatcg    480

gacctcttga acaacggctg gcattgtgga gccgtgtatg gtgctccagc tggtgcgctg    540

gccacaggaa agctcctcgg tctaactcca gactccatgg aagatgctct cggaatcgcg    600

tgcacgcaag cctgtggttt aatgtcggcg caatacggag gcatggtcaa gcgcgtgcaa    660

catggattcg cagcgcgtaa tggtcttctt gggggactgt tggcctatgg tgggtacgag    720

gccatgaagg gtgtcctgga gagatcttat ggcggtttcc tcaaaatgtt caccaagggc    780

aatggcagag agcctcccta caaagaggag gaagtggtgg ccggtctcgg ttcattctgg    840

cataccttta ctattcgcat caagctctat gcctgctgcg gacttgtcca tggtccagtc    900

gaagctatcg aaaagcttca gaggagatac cccgagctct tgaatagagc caacctcagc    960

aacattcgcc atgtttatgt acagctttca acagcctcga acagtcactg tggatggata   1020

ccagaggaga ggcccatcag ttcaatcgca gggcagatga gtgtcgcata catcctcgcc   1080

gtccagctgg tcgaccagca atgtcttctg gctcagtttt ctgagtttga tgacaacttg   1140

gagagaccag aagtgtggga tctggccagg aaggttactc catctcatag cgaagagttt   1200

gatcaagacg gcaactgtct cagtgcgggt cgcgtgagga ttgagttcaa cgatggctct   1260

tctgttacgg aaactgtcga gaagcctctt ggagtcaaag agcccatgcc aaacgaacgg   1320

attctccaca aataccgaac ccttgcgggt agcgtgacgg acgaatcccg ggtgaaagag   1380

attgaggatc ttgtcctcag cctggacagg ctcaccgaca ttaccccatt gctggagctg   1440

cttaattgtc ccgtgaaatc gccactggta taa                                1473


<210>  16
<211>  490
<212>  PRT
<213>  Aspergillus terreus

<400>  16

Met Thr Lys Gln Ser Ala Asp Ser Asn Ala Lys Ser Gly Val Thr Ala 
1               5                   10                  15      


Glu Ile Cys His Trp Ala Ser Asn Leu Ala Thr Asp Asp Ile Pro Ser 
            20                  25                  30          


Asp Val Leu Glu Arg Ala Lys Tyr Leu Ile Leu Asp Gly Ile Ala Cys 
        35                  40                  45              


Ala Trp Val Gly Ala Arg Val Pro Trp Ser Glu Lys Tyr Val Gln Ala 
    50                  55                  60                  


Thr Met Ser Phe Glu Pro Pro Gly Ala Cys Arg Val Ile Gly Tyr Gly 
65                  70                  75                  80  


Gln Lys Leu Gly Pro Val Ala Ala Ala Met Thr Asn Ser Ala Phe Ile 
                85                  90                  95      


Gln Ala Thr Glu Leu Asp Asp Tyr His Ser Glu Ala Pro Leu His Ser 
            100                 105                 110         


Ala Ser Ile Val Leu Pro Ala Val Phe Ala Ala Ser Glu Val Leu Ala 
        115                 120                 125             


Glu Gln Gly Lys Thr Ile Ser Gly Ile Asp Val Ile Leu Ala Ala Ile 
    130                 135                 140                 


Val Gly Phe Glu Ser Gly Pro Arg Ile Gly Lys Ala Ile Tyr Gly Ser 
145                 150                 155                 160 


Asp Leu Leu Asn Asn Gly Trp His Cys Gly Ala Val Tyr Gly Ala Pro 
                165                 170                 175     


Ala Gly Ala Leu Ala Thr Gly Lys Leu Leu Gly Leu Thr Pro Asp Ser 
            180                 185                 190         


Met Glu Asp Ala Leu Gly Ile Ala Cys Thr Gln Ala Cys Gly Leu Met 
        195                 200                 205             


Ser Ala Gln Tyr Gly Gly Met Val Lys Arg Val Gln His Gly Phe Ala 
    210                 215                 220                 


Ala Arg Asn Gly Leu Leu Gly Gly Leu Leu Ala Tyr Gly Gly Tyr Glu 
225                 230                 235                 240 


Ala Met Lys Gly Val Leu Glu Arg Ser Tyr Gly Gly Phe Leu Lys Met 
                245                 250                 255     


Phe Thr Lys Gly Asn Gly Arg Glu Pro Pro Tyr Lys Glu Glu Glu Val 
            260                 265                 270         


Val Ala Gly Leu Gly Ser Phe Trp His Thr Phe Thr Ile Arg Ile Lys 
        275                 280                 285             


Leu Tyr Ala Cys Cys Gly Leu Val His Gly Pro Val Glu Ala Ile Glu 
    290                 295                 300                 


Lys Leu Gln Arg Arg Tyr Pro Glu Leu Leu Asn Arg Ala Asn Leu Ser 
305                 310                 315                 320 


Asn Ile Arg His Val Tyr Val Gln Leu Ser Thr Ala Ser Asn Ser His 
                325                 330                 335     


Cys Gly Trp Ile Pro Glu Glu Arg Pro Ile Ser Ser Ile Ala Gly Gln 
            340                 345                 350         


Met Ser Val Ala Tyr Ile Leu Ala Val Gln Leu Val Asp Gln Gln Cys 
        355                 360                 365             


Leu Leu Ala Gln Phe Ser Glu Phe Asp Asp Asn Leu Glu Arg Pro Glu 
    370                 375                 380                 


Val Trp Asp Leu Ala Arg Lys Val Thr Pro Ser His Ser Glu Glu Phe 
385                 390                 395                 400 


Asp Gln Asp Gly Asn Cys Leu Ser Ala Gly Arg Val Arg Ile Glu Phe 
                405                 410                 415     


Asn Asp Gly Ser Ser Val Thr Glu Thr Val Glu Lys Pro Leu Gly Val 
            420                 425                 430         


Lys Glu Pro Met Pro Asn Glu Arg Ile Leu His Lys Tyr Arg Thr Leu 
        435                 440                 445             


Ala Gly Ser Val Thr Asp Glu Ser Arg Val Lys Glu Ile Glu Asp Leu 
    450                 455                 460                 


Val Leu Ser Leu Asp Arg Leu Thr Asp Ile Thr Pro Leu Leu Glu Leu 
465                 470                 475                 480 


Leu Asn Cys Pro Val Lys Ser Pro Leu Val 
                485                 490 


<210>  17
<211>  906
<212>  DNA
<213>  Aspergillus terreus

<400>  17
atggactcta aaatccagac aaatgttcca ttaccaaagg caccccttat ccaaaaagcc     60

cgtgggaagc gtacgaaagg cattcctgca ttggttgcgg gtgcttgtgc tggggcagtt    120

gaaatctcca tcacctaccc tttcgaatcg gctaaaactc gcgcccagct taagcggcga    180

aaccatgatg tggcagctat aaaacctgga atccgaggct ggtatgctgg gtatggagcc    240

accttggtag gaaccacagt gaaagcctcc gttcaatttg cctcattcaa tatttatcgc    300

tcggcccttt cgggcccaaa tggagagctc tcaactggag cttccgtcct ggctgggttt    360

ggggctggcg tgaccgaggc tgtcttagcc gtaaccccag cggaggcgat caagacaaaa    420

atcattgatg caaggaaggt tggaaatgca gagttaagta cgacttttgg cgcgatagct    480

gggatccttc gagatcgggg accgcttgga ttcttctctg cggttggtcc tacaattttg    540

cggcagtcct ccaatgcggc agtgaagttc actgtttata acgaacttat tgggctggcc    600

cgaaaatact cgaagaatgg cgaagacgtg caccctctgg caagcacctt ggtcggttct    660

gttactggag tttgctgcgc ctggtcgaca cagccactgg acgtgatcaa gacacgaatg    720

caatctcttc aggcaagaca actgtacgga aataccttca actgcgtgaa aacactcctg    780

cgcagtgaag gcattggcgt tttctggtcc ggtgtctggt ttcggacagg gagactttcc    840

cttacctcgg ccatcatgtt tcccgtctac gagaaagtct acaagttctt gacgcaacca    900

aactga                                                               906


<210>  18
<211>  301
<212>  PRT
<213>  Aspergillus terreus

<400>  18

Met Asp Ser Lys Ile Gln Thr Asn Val Pro Leu Pro Lys Ala Pro Leu 
1               5                   10                  15      


Ile Gln Lys Ala Arg Gly Lys Arg Thr Lys Gly Ile Pro Ala Leu Val 
            20                  25                  30          


Ala Gly Ala Cys Ala Gly Ala Val Glu Ile Ser Ile Thr Tyr Pro Phe 
        35                  40                  45              


Glu Ser Ala Lys Thr Arg Ala Gln Leu Lys Arg Arg Asn His Asp Val 
    50                  55                  60                  


Ala Ala Ile Lys Pro Gly Ile Arg Gly Trp Tyr Ala Gly Tyr Gly Ala 
65                  70                  75                  80  


Thr Leu Val Gly Thr Thr Val Lys Ala Ser Val Gln Phe Ala Ser Phe 
                85                  90                  95      


Asn Ile Tyr Arg Ser Ala Leu Ser Gly Pro Asn Gly Glu Leu Ser Thr 
            100                 105                 110         


Gly Ala Ser Val Leu Ala Gly Phe Gly Ala Gly Val Thr Glu Ala Val 
        115                 120                 125             


Leu Ala Val Thr Pro Ala Glu Ala Ile Lys Thr Lys Ile Ile Asp Ala 
    130                 135                 140                 


Arg Lys Val Gly Asn Ala Glu Leu Ser Thr Thr Phe Gly Ala Ile Ala 
145                 150                 155                 160 


Gly Ile Leu Arg Asp Arg Gly Pro Leu Gly Phe Phe Ser Ala Val Gly 
                165                 170                 175     


Pro Thr Ile Leu Arg Gln Ser Ser Asn Ala Ala Val Lys Phe Thr Val 
            180                 185                 190         


Tyr Asn Glu Leu Ile Gly Leu Ala Arg Lys Tyr Ser Lys Asn Gly Glu 
        195                 200                 205             


Asp Val His Pro Leu Ala Ser Thr Leu Val Gly Ser Val Thr Gly Val 
    210                 215                 220                 


Cys Cys Ala Trp Ser Thr Gln Pro Leu Asp Val Ile Lys Thr Arg Met 
225                 230                 235                 240 


Gln Ser Leu Gln Ala Arg Gln Leu Tyr Gly Asn Thr Phe Asn Cys Val 
                245                 250                 255     


Lys Thr Leu Leu Arg Ser Glu Gly Ile Gly Val Phe Trp Ser Gly Val 
            260                 265                 270         


Trp Phe Arg Thr Gly Arg Leu Ser Leu Thr Ser Ala Ile Met Phe Pro 
        275                 280                 285             


Val Tyr Glu Lys Val Tyr Lys Phe Leu Thr Gln Pro Asn 
    290                 295                 300     


<210>  19
<211>  1212
<212>  DNA
<213>  Aspergillus terreus

<400>  19
atgggccacg gtgacactga gtccccgaac ccaacgacga ccacggaagg tagcggacaa     60

aacgagccag agaaaaaggg ccgtgatatt ccattatgga gaaaatgtgt cattacgttt    120

gttgttagtt ggatgactct agtcgttact ttctccagta cttgtcttct tcctgccgcc    180

cctgaaatcg cgaatgaatt tgatatgact gtcgagacta tcaacatctc caatgctggt    240

gtcctagttg ccatgggata ttcatccctc atatggggtc ccatgaacaa gttagtcggc    300

cggcggacat catacaatct ggccatttca atgctttgtg catgctccgc tggaacggca    360

gcggcgataa acgaggaaat gttcatagcg ttcagagtgt tgagcggctt aaccggaacc    420

tcgttcatgg tctcaggcca aactgttctt gcagatatct ttgagcctgt ttaccgtggg    480

acggccgtag gtttcttcat ggccgggact ctttctggcc ctgcaatagg cccctgcgtg    540

ggaggggtca tcgtcacttt cacgagttgg cgtgttatct tctggcttca actaggtatg    600

agcgggctgg ggctcgtgct ttctctgcta tttttcccga aaatcgaagg aaattctgag    660

aaggtctcaa cggcgtttaa accgaccaca cttgtcacaa tcatatcgaa attctcccca    720

acggatgtgc tcaagcagtg ggtgtatcca aatgtctttc ttgccgactt atgctgtggc    780

ctcctggcaa tcacgcaata ttcgatcctg acttcagctc gtgccatatt caactcacga    840

tttcatttaa cgactgccct agtatcgggt ctcttctacc tcgctccagg tgccgggttc    900

ctgataggca gtctcgtcgg cggtaaactt tcggatcgca ccgttcggag atacatagta    960

aagcgcggat tccgtctccc tcaggatcga ctccacagcg ggctcatcac attgttcgcc   1020

gtgctgcccg caggaacgct catttacggg tggacactcc aagaggataa gggtgatatg   1080

gtagtgccca taatcgcggc gttcttcgcg ggctgggggc tcatgggcag ttttaactgc   1140

ctgaacactt acgtggctgg tttgttccac accctcattt atctattccc tttgtgtaca   1200

tgcccacaat aa                                                       1212


<210>  20
<211>  403
<212>  PRT
<213>  Aspergillus terreus

<400>  20

Met Gly His Gly Asp Thr Glu Ser Pro Asn Pro Thr Thr Thr Thr Glu 
1               5                   10                  15      


Gly Ser Gly Gln Asn Glu Pro Glu Lys Lys Gly Arg Asp Ile Pro Leu 
            20                  25                  30          


Trp Arg Lys Cys Val Ile Thr Phe Val Val Ser Trp Met Thr Leu Val 
        35                  40                  45              


Val Thr Phe Ser Ser Thr Cys Leu Leu Pro Ala Ala Pro Glu Ile Ala 
    50                  55                  60                  


Asn Glu Phe Asp Met Thr Val Glu Thr Ile Asn Ile Ser Asn Ala Gly 
65                  70                  75                  80  


Val Leu Val Ala Met Gly Tyr Ser Ser Leu Ile Trp Gly Pro Met Asn 
                85                  90                  95      


Lys Leu Val Gly Arg Arg Thr Ser Tyr Asn Leu Ala Ile Ser Met Leu 
            100                 105                 110         


Cys Ala Cys Ser Ala Gly Thr Ala Ala Ala Ile Asn Glu Glu Met Phe 
        115                 120                 125             


Ile Ala Phe Arg Val Leu Ser Gly Leu Thr Gly Thr Ser Phe Met Val 
    130                 135                 140                 


Ser Gly Gln Thr Val Leu Ala Asp Ile Phe Glu Pro Val Tyr Arg Gly 
145                 150                 155                 160 


Thr Ala Val Gly Phe Phe Met Ala Gly Thr Leu Ser Gly Pro Ala Ile 
                165                 170                 175     


Gly Pro Cys Val Gly Gly Val Ile Val Thr Phe Thr Ser Trp Arg Val 
            180                 185                 190         


Ile Phe Trp Leu Gln Leu Gly Met Ser Gly Leu Gly Leu Val Leu Ser 
        195                 200                 205             


Leu Leu Phe Phe Pro Lys Ile Glu Gly Asn Ser Glu Lys Val Ser Thr 
    210                 215                 220                 


Ala Phe Lys Pro Thr Thr Leu Val Thr Ile Ile Ser Lys Phe Ser Pro 
225                 230                 235                 240 


Thr Asp Val Leu Lys Gln Trp Val Tyr Pro Asn Val Phe Leu Ala Asp 
                245                 250                 255     


Leu Cys Cys Gly Leu Leu Ala Ile Thr Gln Tyr Ser Ile Leu Thr Ser 
            260                 265                 270         


Ala Arg Ala Ile Phe Asn Ser Arg Phe His Leu Thr Thr Ala Leu Val 
        275                 280                 285             


Ser Gly Leu Phe Tyr Leu Ala Pro Gly Ala Gly Phe Leu Ile Gly Ser 
    290                 295                 300                 


Leu Val Gly Gly Lys Leu Ser Asp Arg Thr Val Arg Arg Tyr Ile Val 
305                 310                 315                 320 


Lys Arg Gly Phe Arg Leu Pro Gln Asp Arg Leu His Ser Gly Leu Ile 
                325                 330                 335     


Thr Leu Phe Ala Val Leu Pro Ala Gly Thr Leu Ile Tyr Gly Trp Thr 
            340                 345                 350         


Leu Gln Glu Asp Lys Gly Asp Met Val Val Pro Ile Ile Ala Ala Phe 
        355                 360                 365             


Phe Ala Gly Trp Gly Leu Met Gly Ser Phe Asn Cys Leu Asn Thr Tyr 
    370                 375                 380                 


Val Ala Gly Leu Phe His Thr Leu Ile Tyr Leu Phe Pro Leu Cys Thr 
385                 390                 395                 400 


Cys Pro Gln 
            


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  21
tcataaccga tgtggggatt                                                 20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  22
acgttttcaa gcccgttatg                                                 20


<210>  23
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  23
gagaatgcat atggctgctc cccgccagcc                                      30


<210>  24
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  24
gagagcggcc gcctaggcct tgacgatctt gc                                   32


<210>  25
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  25
cccacagact ggctcaacc                                                  19


<210>  26
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  26
aagcctcatc tgccttttgg                                                 20


<210>  27
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  27
acgctcgaag gagtcacg                                                   18


<210>  28
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  28
gagaatgcat atggctcccc cccaagc                                         27


<210>  29
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  29
gagagcggcc gcatcatagt gccggcacag acc                                  33


<210>  30
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  30
cccacagact ggctcaacc                                                  19


<210>  31
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  31
accgctccgt caaaatatcc                                                 20


<210>  32
<211>  1476
<212>  DNA
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  32
atgcataaac agagtgcgga cagcaacgct aagagcggag tcacggccga gatttgccac     60

tgggcgtcta atttagcaac agacgacata cccagcgatg tgctggaaag agctaagtac    120

ctgatcctcg atggtatcgc ctgtgcctgg gttggtgccc gtgttccttg gtccgagaag    180

tatgttcagg ctaccatgtc gtttgaaccc ccgggtgcct gtcgcgtcat tggatatggc    240

cagaagctgg ggccggtggc agctgcgatg actaactctg cttttattca ggcgactgaa    300

ttggatgact accactcaga ggcccccctt cactctgcgt cgatcgtgct gccggcagtg    360

ttcgcagcca gcgaggtcct agcagagcaa gggaagacga tttccggtat tgacgtcatt    420

ctggcagcca tcgttggctt tgagagtggt ccacgcatcg gcaaggcgat ctacgggtcg    480

gacctcctta acaatgggtg gcattgtggt gcagtgtatg gggctcccgc aggagctctg    540

gcgaccggca aattgcttgg actgactccg gactccatgg aagatgctct tggtatagct    600

tgcacccagg cttgcggact catgtcagcc caatatggcg gaatggttaa aagggtgcaa    660

catggattcg ccgctcgtaa cggcctctta ggcggcctgt tggcatatgg cgggtatgaa    720

gcgatgaagg gtgtgctcga acgttcatac ggaggttttc tgaagatgtt caccaagggc    780

aatgggcgtg agccccccta caaagaagaa gaagtggtgg ccggcttggg ctccttctgg    840

cacaccttca caatccggat taaactgtac gcttgctgtg ggttggtcca tggtcctgtc    900

gaggcgatcg aaaaactcca acggcgctat cctgagcttc tcaaccgggc caatctatcg    960

aatatcagac atgtatacgt gcagctaagc acggctagta acagccattg cggatggata   1020

cccgaggaaa ggccgatttc ttctatagca ggccaaatgt ccgtcgccta catccttgcc   1080

gtccagctcg ttgatcagca atgcctgtta gcccagttct ctgagtttga tgataatctc   1140

gaacgacctg aggtctggga ccttgcgagg aaagttactc cgtcgcactc cgaagaattc   1200

gatcaggatg gaaattgtct ttcagccgga cgcgtccgaa tcgagttcaa cgacggctca   1260

agtgtaaccg aaacagtgga gaaacctctg ggcgtcaagg aaccaatgcc aaacgaacgg   1320

attctacaca agtaccgaac gttggctggt tcggtcaccg atgagtcccg cgtaaaggaa   1380

atcgaagacc tcgtcctgtc cttggaccgg ttgacagata tcactcctct tctcgaactg   1440

ctcaactgcc cagtaaagtc gccactagtg taatag                             1476


<210>  33
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  33

Met His Lys Gln Ser Ala Asp Ser Asn Ala Lys Ser Gly Val Thr Ala 
1               5                   10                  15      


Glu Ile Cys His Trp Ala Ser Asn Leu Ala Thr Asp Asp Ile Pro Ser 
            20                  25                  30          


Asp Val Leu Glu Arg Ala Lys Tyr Leu Ile Leu Asp Gly Ile Ala Cys 
        35                  40                  45              


Ala Trp Val Gly Ala Arg Val Pro Trp Ser Glu Lys Tyr Val Gln Ala 
    50                  55                  60                  


Thr Met Ser Phe Glu Pro Pro Gly Ala Cys Arg Val Ile Gly Tyr Gly 
65                  70                  75                  80  


Gln Lys Leu Gly Pro Val Ala Ala Ala Met Thr Asn Ser Ala Phe Ile 
                85                  90                  95      


Gln Ala Thr Glu Leu Asp Asp Tyr His Ser Glu Ala Pro Leu His Ser 
            100                 105                 110         


Ala Ser Ile Val Leu Pro Ala Val Phe Ala Ala Ser Glu Val Leu Ala 
        115                 120                 125             


Glu Gln Gly Lys Thr Ile Ser Gly Ile Asp Val Ile Leu Ala Ala Ile 
    130                 135                 140                 


Val Gly Phe Glu Ser Gly Pro Arg Ile Gly Lys Ala Ile Tyr Gly Ser 
145                 150                 155                 160 


Asp Leu Leu Asn Asn Gly Trp His Cys Gly Ala Val Tyr Gly Ala Pro 
                165                 170                 175     


Ala Gly Ala Leu Ala Thr Gly Lys Leu Leu Gly Leu Thr Pro Asp Ser 
            180                 185                 190         


Met Glu Asp Ala Leu Gly Ile Ala Cys Thr Gln Ala Cys Gly Leu Met 
        195                 200                 205             


Ser Ala Gln Tyr Gly Gly Met Val Lys Arg Val Gln His Gly Phe Ala 
    210                 215                 220                 


Ala Arg Asn Gly Leu Leu Gly Gly Leu Leu Ala Tyr Gly Gly Tyr Glu 
225                 230                 235                 240 


Ala Met Lys Gly Val Leu Glu Arg Ser Tyr Gly Gly Phe Leu Lys Met 
                245                 250                 255     


Phe Thr Lys Gly Asn Gly Arg Glu Pro Pro Tyr Lys Glu Glu Glu Val 
            260                 265                 270         


Val Ala Gly Leu Gly Ser Phe Trp His Thr Phe Thr Ile Arg Ile Lys 
        275                 280                 285             


Leu Tyr Ala Cys Cys Gly Leu Val His Gly Pro Val Glu Ala Ile Glu 
    290                 295                 300                 


Lys Leu Gln Arg Arg Tyr Pro Glu Leu Leu Asn Arg Ala Asn Leu Ser 
305                 310                 315                 320 


Asn Ile Arg His Val Tyr Val Gln Leu Ser Thr Ala Ser Asn Ser His 
                325                 330                 335     


Cys Gly Trp Ile Pro Glu Glu Arg Pro Ile Ser Ser Ile Ala Gly Gln 
            340                 345                 350         


Met Ser Val Ala Tyr Ile Leu Ala Val Gln Leu Val Asp Gln Gln Cys 
        355                 360                 365             


Leu Leu Ala Gln Phe Ser Glu Phe Asp Asp Asn Leu Glu Arg Pro Glu 
    370                 375                 380                 


Val Trp Asp Leu Ala Arg Lys Val Thr Pro Ser His Ser Glu Glu Phe 
385                 390                 395                 400 


Asp Gln Asp Gly Asn Cys Leu Ser Ala Gly Arg Val Arg Ile Glu Phe 
                405                 410                 415     


Asn Asp Gly Ser Ser Val Thr Glu Thr Val Glu Lys Pro Leu Gly Val 
            420                 425                 430         


Lys Glu Pro Met Pro Asn Glu Arg Ile Leu His Lys Tyr Arg Thr Leu 
        435                 440                 445             


Ala Gly Ser Val Thr Asp Glu Ser Arg Val Lys Glu Ile Glu Asp Leu 
    450                 455                 460                 


Val Leu Ser Leu Asp Arg Leu Thr Asp Ile Thr Pro Leu Leu Glu Leu 
465                 470                 475                 480 


Leu Asn Cys Pro Val Lys Ser Pro Leu Val 
                485                 490 


<210>  34
<211>  909
<212>  DNA
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  34
atgcatgaat ctaaggtgca aacgaatgtc cctcttccta aagctccact tacacagaag     60

gcccgtggaa agcgcaccaa gggcatccct gcgctggttg caggcgcttg tgctggagct    120

gtcgagattt ctatcacata cccctttgag agcgctaaga cccgcgctca gttgaagcgg    180

cgcaaccacg acgtcgcagc catcaagccg ggtatccggg gttggtatgc gggttacggt    240

gctacgctcg tgggtaccac gttgaaggct tcggtccaat tcgcgtcgtt caacatttac    300

cgctccgctc tttccggccc caacggcgag ctctctacgg gagcatcggt cctcgcgggc    360

ttcggcgctg gcgtcaccga ggccgtcctt gcggtgaccc ccgctgaggc catcaaaaca    420

aagatcatcg acgcgcgtaa ggttggcaac gccgaactca gtaccacctt cggtgctatc    480

gctggcatct tgcgtgatcg cggcccactc ggattcttct ccgcagttgg cccgaccatc    540

cttcgtcaga gctccaacgc tgccgtgaag ttcaccgtct ataacgaatt gattggcctc    600

gcccgcaagt acagtaagaa cggagaggat gtccacccct tggcctccac gctggtcggc    660

agcgtgactg gcgtctgttg cgcctggtcc acgcagcctc tcgatgttat taagacccgc    720

atgcaatccc tgcaggcccg ccagctctac ggcaacacgt ttaattgcgt taagaccctg    780

ctccgcaacg aaggcatcgg tgttttctgg tccggagtct ggttccgtac aggtcgcctt    840

tctctgacta gcgctatcat gttccccgtc tacgagaagg tctacaagtt cttgacccaa    900

cctaactga                                                            909


<210>  35
<211>  302
<212>  PRT
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  35

Met His Glu Ser Lys Val Gln Thr Asn Val Pro Leu Pro Lys Ala Pro 
1               5                   10                  15      


Leu Thr Gln Lys Ala Arg Gly Lys Arg Thr Lys Gly Ile Pro Ala Leu 
            20                  25                  30          


Val Ala Gly Ala Cys Ala Gly Ala Val Glu Ile Ser Ile Thr Tyr Pro 
        35                  40                  45              


Phe Glu Ser Ala Lys Thr Arg Ala Gln Leu Lys Arg Arg Asn His Asp 
    50                  55                  60                  


Val Ala Ala Ile Lys Pro Gly Ile Arg Gly Trp Tyr Ala Gly Tyr Gly 
65                  70                  75                  80  


Ala Thr Leu Val Gly Thr Thr Leu Lys Ala Ser Val Gln Phe Ala Ser 
                85                  90                  95      


Phe Asn Ile Tyr Arg Ser Ala Leu Ser Gly Pro Asn Gly Glu Leu Ser 
            100                 105                 110         


Thr Gly Ala Ser Val Leu Ala Gly Phe Gly Ala Gly Val Thr Glu Ala 
        115                 120                 125             


Val Leu Ala Val Thr Pro Ala Glu Ala Ile Lys Thr Lys Ile Ile Asp 
    130                 135                 140                 


Ala Arg Lys Val Gly Asn Ala Glu Leu Ser Thr Thr Phe Gly Ala Ile 
145                 150                 155                 160 


Ala Gly Ile Leu Arg Asp Arg Gly Pro Leu Gly Phe Phe Ser Ala Val 
                165                 170                 175     


Gly Pro Thr Ile Leu Arg Gln Ser Ser Asn Ala Ala Val Lys Phe Thr 
            180                 185                 190         


Val Tyr Asn Glu Leu Ile Gly Leu Ala Arg Lys Tyr Ser Lys Asn Gly 
        195                 200                 205             


Glu Asp Val His Pro Leu Ala Ser Thr Leu Val Gly Ser Val Thr Gly 
    210                 215                 220                 


Val Cys Cys Ala Trp Ser Thr Gln Pro Leu Asp Val Ile Lys Thr Arg 
225                 230                 235                 240 


Met Gln Ser Leu Gln Ala Arg Gln Leu Tyr Gly Asn Thr Phe Asn Cys 
                245                 250                 255     


Val Lys Thr Leu Leu Arg Asn Glu Gly Ile Gly Val Phe Trp Ser Gly 
            260                 265                 270         


Val Trp Phe Arg Thr Gly Arg Leu Ser Leu Thr Ser Ala Ile Met Phe 
        275                 280                 285             


Pro Val Tyr Glu Lys Val Tyr Lys Phe Leu Thr Gln Pro Asn 
    290                 295                 300         


<210>  36
<211>  1467
<212>  DNA
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  36
atgcatggtc gtggtgatac tgaaagtcct aatcctgcta ctacatctga aggttccggt     60

caaaatgagc cggagaagaa gggccgtgac atccctctct ggcggaagtg tgtcatcacg    120

tttgttgtgt cctggatgac tctggtcgtg acttttagct ctacctgtct gcttccggcc    180

gcccccgaga tcgctaacga gtttgatatg accgtggaga ctatcaacat tagcaacgcc    240

ggtgtccttg tggctatggg ctactcctcc ttgatctggg gccctatgaa caagctggtg    300

ggtcgtcgca ccagttacaa cttggccatc tcgatgctgt gcgcgtgctc cgctggtact    360

gccgccgcaa tcaacgagaa aatgtttatc gccttccgcg ttctctccgg cttgactgga    420

acgagcttta tggtttctgg ccaaaccgtc ctggctgata ttttcgaacc tgtctatcgc    480

ggtactgcag tgggcttctt catggcgggc actctctctg gccctgcgat tgcgtgcgtc    540

ggaggcgtca tcgtcacctt cactagctgg cgtgtgatct tttggctgca attgggcatg    600

agcggcctgg gtttggtcct ttccctcctt ttctttccga agatcgaagg cacgagtgag    660

aaggtttcta ctgcttttaa acccactact ctcgtctcga tcatctctaa gttcagtccc    720

acggatgtcc tcaagcagtg ggtgtatcct aacgtcttcc tggccgtttc cgcctgggaa    780

atctgcccct tgcacctgct cgagacgaag tgcagttgtc gcaagcagaa ggatctctgc    840

tgtggcttgc tggccatcac ccagtatagc attcttacct ccgcccgtgc catcttcaac    900

agccgcttcc acctcacaac tgcgctggtc agcggtctgt tctacctcgc gcctggcgct    960

ggtttcttga tcggctctct ggttggcggc aagctgtctg accggaccgt gcgtcgctat   1020

attgtcaagc gcggtttccg tctgccgcag gaccggttgc attctggctt gatcaccctc   1080

tttgccgtcc tcccagccgg aactctgatt tatggctgga ccctccagga ggacaagggt   1140

ggcatggtgg ttccgatcat cgccgctttc ttcgctggat ggggattgat gggctccttt   1200

aactgcctga acacatacgt ggccgtcgag gccctccctc ggaatcgcag cgctgtcatc   1260

gccggtaaat acatgattca atactcgttc tcggccggtt cttccgcctt ggttgtcccc   1320

gtcatcgatg ctctgggtgt gggttggact ttcacccttt gcgtcgtcgc ttccactatc   1380

gccggtctta tcaccgccgc catcgcccgt tggggtatca acatgcaacg ttgggccgag   1440

cgtgctttta acctgccgac acagtaa                                       1467


<210>  37
<211>  488
<212>  PRT
<213>  Artificial

<220>
<223>  Optimised for Aspergillus niger

<400>  37

Met His Gly Arg Gly Asp Thr Glu Ser Pro Asn Pro Ala Thr Thr Ser 
1               5                   10                  15      


Glu Gly Ser Gly Gln Asn Glu Pro Glu Lys Lys Gly Arg Asp Ile Pro 
            20                  25                  30          


Leu Trp Arg Lys Cys Val Ile Thr Phe Val Val Ser Trp Met Thr Leu 
        35                  40                  45              


Val Val Thr Phe Ser Ser Thr Cys Leu Leu Pro Ala Ala Pro Glu Ile 
    50                  55                  60                  


Ala Asn Glu Phe Asp Met Thr Val Glu Thr Ile Asn Ile Ser Asn Ala 
65                  70                  75                  80  


Gly Val Leu Val Ala Met Gly Tyr Ser Ser Leu Ile Trp Gly Pro Met 
                85                  90                  95      


Asn Lys Leu Val Gly Arg Arg Thr Ser Tyr Asn Leu Ala Ile Ser Met 
            100                 105                 110         


Leu Cys Ala Cys Ser Ala Gly Thr Ala Ala Ala Ile Asn Glu Lys Met 
        115                 120                 125             


Phe Ile Ala Phe Arg Val Leu Ser Gly Leu Thr Gly Thr Ser Phe Met 
    130                 135                 140                 


Val Ser Gly Gln Thr Val Leu Ala Asp Ile Phe Glu Pro Val Tyr Arg 
145                 150                 155                 160 


Gly Thr Ala Val Gly Phe Phe Met Ala Gly Thr Leu Ser Gly Pro Ala 
                165                 170                 175     


Ile Ala Cys Val Gly Gly Val Ile Val Thr Phe Thr Ser Trp Arg Val 
            180                 185                 190         


Ile Phe Trp Leu Gln Leu Gly Met Ser Gly Leu Gly Leu Val Leu Ser 
        195                 200                 205             


Leu Leu Phe Phe Pro Lys Ile Glu Gly Thr Ser Glu Lys Val Ser Thr 
    210                 215                 220                 


Ala Phe Lys Pro Thr Thr Leu Val Ser Ile Ile Ser Lys Phe Ser Pro 
225                 230                 235                 240 


Thr Asp Val Leu Lys Gln Trp Val Tyr Pro Asn Val Phe Leu Ala Val 
                245                 250                 255     


Ser Ala Trp Glu Ile Cys Pro Leu His Leu Leu Glu Thr Lys Cys Ser 
            260                 265                 270         


Cys Arg Lys Gln Lys Asp Leu Cys Cys Gly Leu Leu Ala Ile Thr Gln 
        275                 280                 285             


Tyr Ser Ile Leu Thr Ser Ala Arg Ala Ile Phe Asn Ser Arg Phe His 
    290                 295                 300                 


Leu Thr Thr Ala Leu Val Ser Gly Leu Phe Tyr Leu Ala Pro Gly Ala 
305                 310                 315                 320 


Gly Phe Leu Ile Gly Ser Leu Val Gly Gly Lys Leu Ser Asp Arg Thr 
                325                 330                 335     


Val Arg Arg Tyr Ile Val Lys Arg Gly Phe Arg Leu Pro Gln Asp Arg 
            340                 345                 350         


Leu His Ser Gly Leu Ile Thr Leu Phe Ala Val Leu Pro Ala Gly Thr 
        355                 360                 365             


Leu Ile Tyr Gly Trp Thr Leu Gln Glu Asp Lys Gly Gly Met Val Val 
    370                 375                 380                 


Pro Ile Ile Ala Ala Phe Phe Ala Gly Trp Gly Leu Met Gly Ser Phe 
385                 390                 395                 400 


Asn Cys Leu Asn Thr Tyr Val Ala Val Glu Ala Leu Pro Arg Asn Arg 
                405                 410                 415     


Ser Ala Val Ile Ala Gly Lys Tyr Met Ile Gln Tyr Ser Phe Ser Ala 
            420                 425                 430         


Gly Ser Ser Ala Leu Val Val Pro Val Ile Asp Ala Leu Gly Val Gly 
        435                 440                 445             


Trp Thr Phe Thr Leu Cys Val Val Ala Ser Thr Ile Ala Gly Leu Ile 
    450                 455                 460                 


Thr Ala Ala Ile Ala Arg Trp Gly Ile Asn Met Gln Arg Trp Ala Glu 
465                 470                 475                 480 


Arg Ala Phe Asn Leu Pro Thr Gln 
                485             


<210>  38
<211>  296
<212>  PRT
<213>  Aspergillus clavatus

<400>  38

Met Thr Ser Glu Asp Lys Asp His Arg Pro Lys Pro Ser Ser Leu Arg 
1               5                   10                  15      


Ser Ile Ile Ala Gly Ser Thr Ala Gly Ala Val Glu Ile Ala Ile Thr 
            20                  25                  30          


Tyr Pro Ala Glu Phe Ala Lys Thr Arg Ser Gln Leu Asn Arg Arg Leu 
        35                  40                  45              


Pro Asp Ala Lys Lys Leu Pro Trp Pro Pro Phe Gly Gly Gln Trp Tyr 
    50                  55                  60                  


Ala Gly Cys Thr Thr Leu Ile Ile Gly Asn Ser Leu Lys Ala Gly Ile 
65                  70                  75                  80  


Arg Phe Val Ala Phe Asp Thr Phe Lys Ser Leu Leu Gln Asp Glu Asn 
                85                  90                  95      


Gly Lys Ile Ser Gly Pro Lys Thr Val Ile Ala Gly Phe Gly Ala Gly 
            100                 105                 110         


Phe Thr Glu Ser Leu Leu Ala Val Thr Pro Phe Glu Ser Ile Lys Thr 
        115                 120                 125             


Gln Ile Ile Asp Asp Arg Lys Ser Pro Asn Pro Arg Met His Gly Phe 
    130                 135                 140                 


Leu His Gly Thr Lys Leu Ile Tyr Gln Glu Arg Gly Ile Arg Gly Phe 
145                 150                 155                 160 


Phe Gln Gly Phe Val Pro Thr Thr Ala Arg Gln Ala Ala Asn Ser Ala 
                165                 170                 175     


Thr Arg Phe Ser Ser Tyr Thr Met Leu Lys Gln Phe Ala Gln Gly Tyr 
            180                 185                 190         


Val Ala Pro Gly Glu Lys Leu Gly Thr Ala Ser Thr Phe Ala Leu Gly 
        195                 200                 205             


Gly Ile Ala Gly Leu Ile Thr Val Tyr Val Thr Gln Pro Leu Asp Thr 
    210                 215                 220                 


Val Lys Thr Arg Met Gln Ser Leu Glu Ala Ser Lys Asn Tyr Lys Asn 
225                 230                 235                 240 


Ser Phe Val Cys Ala Ala Arg Ile Phe Lys Asp Glu Gly Ile Leu Thr 
                245                 250                 255     


Phe Trp Ser Gly Ala Val Pro Arg Leu Ala Arg Leu Ile Leu Ser Gly 
            260                 265                 270         


Gly Ile Val Phe Thr Met Tyr Glu Lys Thr Met Glu Thr Leu Asp Ser 
        275                 280                 285             


Ile Asp Pro Gln Arg Lys Tyr Ile 
    290                 295     


<210>  39
<211>  296
<212>  PRT
<213>  Aspergillus fumigatus

<400>  39

Met Val Thr Ala Glu Lys Asp Pro Lys Ser Lys Pro Ser Ser Leu Arg 
1               5                   10                  15      


Ser Ile Ile Ala Gly Ser Ser Ala Gly Ala Val Glu Ile Ala Ile Thr 
            20                  25                  30          


Tyr Pro Ala Glu Phe Ala Lys Thr Arg Ser Gln Leu Asn Arg Arg Leu 
        35                  40                  45              


Pro Asp Ala Lys Lys Leu Pro Trp Pro Pro Phe Gly Lys Gln Trp Tyr 
    50                  55                  60                  


Ala Gly Cys Thr Thr Leu Ile Ile Gly Asn Ser Leu Lys Ala Gly Ile 
65                  70                  75                  80  


Arg Phe Val Ala Phe Asp Thr Phe Lys Ser Leu Leu Gln Asp Glu Asn 
                85                  90                  95      


Gly Asn Ile Ser Gly Pro Arg Thr Val Ile Ala Gly Phe Gly Ala Gly 
            100                 105                 110         


Phe Thr Glu Ser Leu Leu Ala Val Thr Pro Phe Glu Ser Ile Lys Thr 
        115                 120                 125             


Gln Leu Ile Asp Asp Arg Lys Ser Pro Asn Pro Arg Met Arg Gly Phe 
    130                 135                 140                 


Leu His Gly Ser Lys Ile Ile Phe Gln Glu Arg Gly Leu Arg Gly Phe 
145                 150                 155                 160 


Phe Gln Gly Phe Val Pro Thr Thr Ala Arg Gln Ala Ala Asn Ser Ala 
                165                 170                 175     


Thr Arg Phe Ser Ser Tyr Thr Met Leu Lys Gln Leu Ala Gln Gly Tyr 
            180                 185                 190         


Val Ala Pro Gly Glu Lys Leu Gly Thr Ala Ser Thr Phe Ala Leu Gly 
        195                 200                 205             


Gly Ile Ala Gly Leu Ile Thr Val Tyr Val Thr Gln Pro Leu Asp Thr 
    210                 215                 220                 


Val Lys Thr Arg Met Gln Ser Leu Glu Ala Ser Lys Asn Tyr Lys Asn 
225                 230                 235                 240 


Ser Phe Val Cys Ala Ala Arg Ile Phe Lys Asp Glu Gly Leu Leu Thr 
                245                 250                 255     


Phe Trp Ser Gly Ala Val Pro Arg Leu Ala Arg Leu Ile Met Ser Gly 
            260                 265                 270         


Gly Ile Val Phe Thr Met Tyr Glu Lys Thr Met Glu Ala Leu Asp Ala 
        275                 280                 285             


Ile Asp Pro Glu Arg Lys Tyr Ile 
    290                 295     


<210>  40
<211>  296
<212>  PRT
<213>  Neosartorya fischeri 

<400>  40

Met Ala Thr Ala Glu Lys Asp Pro Lys Ser Lys Pro Ser Ser Leu Arg 
1               5                   10                  15      


Ser Ile Ile Ala Gly Ser Ser Ala Gly Ala Val Glu Ile Ala Ile Thr 
            20                  25                  30          


Tyr Pro Ala Glu Phe Ala Lys Thr Arg Ser Gln Leu Asn Arg Arg Leu 
        35                  40                  45              


Pro Asp Ala Lys Lys Leu Pro Trp Pro Pro Phe Gly Lys Gln Trp Tyr 
    50                  55                  60                  


Ala Gly Cys Thr Thr Leu Ile Ile Gly Asn Ser Leu Lys Ala Gly Ile 
65                  70                  75                  80  


Arg Phe Val Ala Phe Asp Thr Phe Lys Ser Leu Leu Gln Asp Glu Asn 
                85                  90                  95      


Gly Asn Ile Ser Gly Pro Arg Thr Val Ile Ala Gly Phe Gly Ala Gly 
            100                 105                 110         


Phe Thr Glu Ser Leu Leu Ala Val Thr Pro Phe Glu Ser Ile Lys Thr 
        115                 120                 125             


Gln Leu Ile Asp Asp Arg Lys Ser Pro Asn Pro Arg Met Arg Gly Phe 
    130                 135                 140                 


Leu His Gly Ser Lys Ile Ile Phe Gln Glu Arg Gly Leu Arg Gly Phe 
145                 150                 155                 160 


Phe Gln Gly Phe Val Pro Thr Thr Ala Arg Gln Ala Ala Asn Ser Ala 
                165                 170                 175     


Thr Arg Phe Ser Ser Tyr Thr Met Leu Lys Gln Leu Ala Gln Gly Tyr 
            180                 185                 190         


Val Ala Pro Gly Glu Lys Leu Gly Thr Ala Ser Thr Phe Ala Leu Gly 
        195                 200                 205             


Gly Ile Ala Gly Leu Ile Thr Val Tyr Val Thr Gln Pro Leu Asp Thr 
    210                 215                 220                 


Val Lys Thr Arg Met Gln Ser Leu Glu Ala Ser Lys Asn Tyr Lys Asn 
225                 230                 235                 240 


Ser Phe Val Cys Ala Ala Arg Ile Phe Lys Asp Glu Gly Leu Leu Thr 
                245                 250                 255     


Phe Trp Ser Gly Ala Val Pro Arg Leu Ala Arg Leu Ile Met Ser Gly 
            260                 265                 270         


Gly Ile Val Phe Thr Met Tyr Glu Lys Thr Met Glu Ala Leu Asp Ser 
        275                 280                 285             


Ile Asp Pro Glu Arg Lys Tyr Ile 
    290                 295     


<210>  41
<211>  297
<212>  PRT
<213>  Neurospora crassa

<400>  41

Met Ser Ser Ala Ala Thr Lys Asp Asp Asn Ala Arg Ala His Pro Ala 
1               5                   10                  15      


Val Lys Gly Pro Ser Ala Leu Arg Ser Ile Leu Ala Gly Ala Thr Ala 
            20                  25                  30          


Gly Ala Val Glu Ile Val Ala Lys Thr Arg Thr Gln Leu Asn Arg Arg 
        35                  40                  45              


Leu Ala Glu Gly Gln Lys Leu Pro Trp Pro Pro Phe Gly Ala Gln Trp 
    50                  55                  60                  


Tyr Ala Gly Cys Thr Thr Leu Ile Ile Gly Asn Ser Leu Lys Ala Gly 
65                  70                  75                  80  


Ile Arg Phe Val Ala Phe Asp Gln Tyr Lys Lys Leu Leu Ser Asp Ser 
                85                  90                  95      


Asn Gly Lys Leu Ser Gly Pro Gly Thr Val Leu Ala Gly Phe Gly Ala 
            100                 105                 110         


Gly Val Thr Glu Ser Leu Leu Ala Val Thr Pro Thr Glu Ser Ile Lys 
        115                 120                 125             


Thr Thr Leu Ile Asp Asp Arg Lys Ser Ala Lys Pro Arg Leu Arg Gly 
    130                 135                 140                 


Phe Leu Asp Ala Val Pro Val Ile Tyr Arg Glu Arg Gly Ile Arg Gly 
145                 150                 155                 160 


Phe Phe Gln Gly Phe Val Pro Thr Thr Ala Arg Gln Ala Ala Asn Ser 
                165                 170                 175     


Ala Thr Arg Phe Ser Thr Tyr Thr Ala Leu Lys Gln Leu Ala Glu Ser 
            180                 185                 190         


Tyr Thr Ala Pro Gly Glu Lys Leu Gly Ala Val Gly Thr Phe Ala Met 
        195                 200                 205             


Gly Gly Ile Ala Gly Leu Ile Thr Val Tyr Val Thr Gln Pro Leu Asp 
    210                 215                 220                 


Thr Ile Lys Thr Arg Met Gln Ser Ile Glu Ala Lys Gln Leu Tyr Gly 
225                 230                 235                 240 


Asn Ser Phe Arg Cys Ala Ser Ile Ile Phe Lys Gln Glu Gly Val Leu 
                245                 250                 255     


Thr Phe Trp Ser Gly Ala Leu Pro Arg Leu Ala Arg Leu Ile Leu Ser 
            260                 265                 270         


Gly Gly Ile Val Phe Thr Met Tyr Glu Lys Ser Met Asp Leu Phe Asp 
        275                 280                 285             


Arg Leu Asp Pro Glu Arg Lys Tyr Ile 
    290                 295         


<210>  42
<211>  297
<212>  PRT
<213>  Talaromyces stipitatus 

<400>  42

Met Ala Ser Asn Lys Asp Gln Asp Gln Arg Pro Lys Pro Ser Ser Phe 
1               5                   10                  15      


Arg Ser Ile Ile Ala Gly Ser Thr Ala Gly Ala Val Glu Val Ala Ile 
            20                  25                  30          


Thr Tyr Pro Ala Glu Phe Ala Lys Thr Arg Thr Gln Leu Asn Arg Arg 
        35                  40                  45              


Leu Pro Asp Ala Gly Lys Leu Pro Trp Pro Pro Phe Gly Lys Gln Trp 
    50                  55                  60                  


Tyr Ala Gly Cys Thr Thr Leu Ile Ile Gly Asn Ser Leu Lys Ala Gly 
65                  70                  75                  80  


Ile Arg Phe Val Ala Phe Asp Lys Phe Lys Thr Leu Leu Gln Asp Glu 
                85                  90                  95      


Asn Gly Asn Ile Ser Gly Pro Arg Thr Val Ile Ala Gly Phe Gly Ala 
            100                 105                 110         


Gly Phe Thr Glu Ser Ile Leu Ala Val Thr Pro Phe Glu Ser Ile Lys 
        115                 120                 125             


Thr Gln Leu Ile Asp Asp Arg Lys Ser Ala Asn Pro Arg Met Arg Gly 
    130                 135                 140                 


Phe Leu His Gly Ser Lys Ile Ile Ala Gln Glu Arg Gly Ile Arg Gly 
145                 150                 155                 160 


Phe Leu Gln Gly Leu Val Pro Thr Thr Ala Arg Gln Ala Ala Asn Ser 
                165                 170                 175     


Ala Val Arg Phe Ser Ser Tyr Thr Thr Ile Lys Gln Phe Val Gln Gly 
            180                 185                 190         


Tyr Ala Ala Pro Gly Glu Lys Leu Gly Val Leu Ser Thr Phe Ala Ile 
        195                 200                 205             


Gly Gly Ala Ala Gly Val Ile Thr Val Tyr Ala Thr Gln Pro Leu Asp 
    210                 215                 220                 


Thr Val Lys Thr Arg Met Gln Ser Leu Glu Ala Arg Arg Asn Tyr Lys 
225                 230                 235                 240 


Asn Ser Phe Ala Cys Phe Ser Gln Ile Ile Lys Asn Glu Gly Val Leu 
                245                 250                 255     


Thr Leu Trp Ser Gly Ala Leu Pro Arg Leu Ala Arg Leu Ile Leu Ser 
            260                 265                 270         


Gly Gly Ile Val Phe Thr Met Tyr Glu Lys Thr Met Glu Gly Leu Asp 
        275                 280                 285             


Lys Leu Asp Pro Glu Arg Lys Tyr Ile 
    290                 295         


<210>  43
<211>  296
<212>  PRT
<213>  Paracoccidioides brasiliensis 

<400>  43

Met Ala Thr Ser Glu Ser Asp Arg Arg Pro Lys Pro Ser Ala Leu Arg 
1               5                   10                  15      


Ser Ile Ile Ala Gly Ser Thr Ala Gly Ala Val Glu Ile Ser Ile Thr 
            20                  25                  30          


Tyr Pro Ala Glu Phe Ala Lys Thr Arg Thr Gln Leu Asn Arg Arg Leu 
        35                  40                  45              


Pro Asp Ser Lys Lys Leu Pro Trp Pro Pro Phe Gly Lys Ala Trp Tyr 
    50                  55                  60                  


Ala Gly Cys Thr Thr Leu Ile Val Gly Asn Ser Leu Lys Ala Gly Ile 
65                  70                  75                  80  


Arg Phe Val Ala Phe Asp Phe Phe Lys Ser Ile Leu Gln Asp Glu Asn 
                85                  90                  95      


Gly Lys Ile Ser Gly Pro Arg Thr Val Val Ala Gly Phe Gly Ala Gly 
            100                 105                 110         


Phe Thr Glu Ser Leu Leu Ala Val Thr Pro Phe Glu Ser Ile Lys Thr 
        115                 120                 125             


Gln Leu Ile Asp Asp Arg Lys Ser Pro Asn Pro Arg Met Arg Gly Phe 
    130                 135                 140                 


Leu His Gly Thr Ser Val Ile Phe Arg Glu Arg Gly Ile Arg Gly Phe 
145                 150                 155                 160 


Phe Gln Gly Phe Val Pro Thr Thr Ala Arg Gln Ala Ala Asn Ser Ala 
                165                 170                 175     


Thr Arg Phe Gly Ser Tyr Thr Thr Ile Arg Gln Phe Ala Gln Gly Tyr 
            180                 185                 190         


Ile Ala Pro Gly Glu Lys Leu Gly Ala Ala Ser Thr Phe Ala Ile Gly 
        195                 200                 205             


Gly Leu Ala Gly Leu Ile Thr Val Tyr Val Thr Gln Pro Leu Asp Thr 
    210                 215                 220                 


Ile Lys Thr Arg Met Gln Ser Ile Glu Ala Arg Lys Asn Tyr Lys Asn 
225                 230                 235                 240 


Ser Phe Ser Cys Ala Ala Ser Ile Leu Lys Asn Glu Gly Ile Leu Thr 
                245                 250                 255     


Phe Trp Ser Gly Ala Leu Pro Arg Leu Ala Arg Leu Val Met Ser Gly 
            260                 265                 270         


Gly Ile Val Phe Thr Met Tyr Glu Lys Thr Met Glu Gly Leu Asp Leu 
        275                 280                 285             


Leu Asp Pro Glu Arg Asn Tyr Ile 
    290                 295     


<210>  44
<211>  295
<212>  PRT
<213>  Sordaria macrospora 

<400>  44

Met Ser Ser Thr Ala Thr Lys Asp Asp Asn Gln His Pro Ala Leu Lys 
1               5                   10                  15      


Gly Pro Ser Ala Leu Arg Ser Ile Leu Ala Gly Ser Thr Ala Gly Ala 
            20                  25                  30          


Val Glu Ile Val Ala Lys Thr Arg Thr Gln Leu Asn Arg Arg Leu Ala 
        35                  40                  45              


Glu Gly Gln Lys Leu Pro Trp Pro Pro Phe Gly Lys Gln Trp Tyr Ala 
    50                  55                  60                  


Gly Cys Thr Thr Leu Ile Ile Gly Asn Ser Ala Lys Ala Gly Ile Arg 
65                  70                  75                  80  


Phe Val Ala Phe Asp Gln Tyr Lys Lys Leu Leu Ser Gly Pro Asp Gly 
                85                  90                  95      


Lys Met Ser Gly Pro Met Thr Val Leu Ala Gly Phe Gly Ala Gly Val 
            100                 105                 110         


Thr Glu Ser Leu Leu Ala Val Thr Pro Thr Glu Ser Ile Lys Thr Thr 
        115                 120                 125             


Leu Ile Asp Asp Arg Lys Ser Ala Lys Pro Arg Leu Arg Gly Phe Leu 
    130                 135                 140                 


His Ala Val Pro Ile Ile Ala Arg Glu Arg Gly Ile Arg Gly Phe Phe 
145                 150                 155                 160 


Gln Gly Phe Val Pro Thr Thr Ala Arg Gln Ala Ala Asn Ser Ala Thr 
                165                 170                 175     


Arg Phe Gly Ser Tyr Thr Ala Leu Lys Gln Leu Ala Glu Ser Tyr Thr 
            180                 185                 190         


Ala Pro Gly Glu Lys Leu Gly Ala Val Gly Thr Phe Ala Met Gly Gly 
        195                 200                 205             


Ile Ala Gly Leu Ile Thr Val Tyr Val Thr Gln Pro Leu Asp Thr Ile 
    210                 215                 220                 


Lys Thr Arg Met Gln Ser Ile Glu Ala Lys Gln Leu Tyr Gly Asn Ser 
225                 230                 235                 240 


Phe Arg Cys Ala Ser Ile Ile Phe Lys Gln Glu Gly Val Phe Thr Phe 
                245                 250                 255     


Trp Ser Gly Ala Leu Pro Arg Leu Ala Arg Leu Ile Met Ser Gly Gly 
            260                 265                 270         


Ile Val Phe Thr Met Tyr Glu Lys Ser Met Glu Leu Phe Asp Arg Phe 
        275                 280                 285             


Asp Pro Glu Arg Gln Tyr Ile 
    290                 295 


<210>  45
<211>  296
<212>  PRT
<213>  Aspergillus oryzae

<400>  45

Met Ser Ala Met Glu Lys Asp His Asn Arg Lys Pro Ser Ser Leu Arg 
1               5                   10                  15      


Ser Ile Ile Ala Gly Ser Thr Ala Gly Ala Ile Glu Ile Ala Ile Thr 
            20                  25                  30          


Tyr Pro Ala Glu Phe Ala Lys Thr Arg Ser Gln Leu Asn Arg Lys Leu 
        35                  40                  45              


Pro Asp Gly Lys Lys Leu Pro Trp Pro Pro Phe Gly Lys Gln Trp Tyr 
    50                  55                  60                  


Ala Gly Cys Thr Thr Leu Ile Ile Gly Asn Ser Leu Lys Ala Gly Ile 
65                  70                  75                  80  


Arg Phe Val Ala Phe Asp Arg Phe Lys Ser Leu Leu Gln Asp Glu Asn 
                85                  90                  95      


Gly Lys Ile Ser Gly Pro Arg Thr Val Ile Ala Gly Phe Gly Ala Gly 
            100                 105                 110         


Phe Thr Glu Ser Leu Leu Ala Val Thr Pro Phe Glu Ser Ile Lys Thr 
        115                 120                 125             


Gln Leu Ile Asp Asp Arg Lys Ser Ala Asn Pro Arg Met Arg Gly Phe 
    130                 135                 140                 


Leu His Gly Ser Lys Leu Ile Phe Gln Glu Arg Gly Ile Arg Gly Phe 
145                 150                 155                 160 


Phe Gln Gly Phe Val Pro Thr Thr Ala Arg Gln Ala Ala Asn Ser Ala 
                165                 170                 175     


Thr Arg Phe Ser Ser Tyr Thr Met Leu Lys Gln Leu Ala Glu Ser Tyr 
            180                 185                 190         


Val Ala Pro Gly Glu Lys Leu Gly Thr Ala Ser Thr Phe Ala Ile Gly 
        195                 200                 205             


Gly Met Ala Gly Phe Ile Thr Val Tyr Val Thr Gln Pro Leu Asp Thr 
    210                 215                 220                 


Val Lys Thr Arg Met Gln Ser Leu Glu Ala Ser Lys Asn Tyr Lys Asn 
225                 230                 235                 240 


Ser Phe Val Cys Ala Ser Arg Ile Phe Lys Asp Glu Gly Leu Phe Thr 
                245                 250                 255     


Phe Trp Ser Gly Ala Val Pro Arg Leu Ala Arg Leu Ile Leu Ser Gly 
            260                 265                 270         


Gly Ile Val Phe Thr Met Tyr Glu Lys Thr Met Asp Ala Leu Asp Ser 
        275                 280                 285             


Leu Asp Ser Lys Arg Gln Tyr Ile 
    290                 295     


<210>  46
<211>  296
<212>  PRT
<213>  Aspergillus niger

<400>  46

Met Ala Thr Ser Glu Asn Asp Lys Arg Ser Lys Pro Ser Ser Leu Arg 
1               5                   10                  15      


Ser Ile Ile Ala Gly Ser Thr Ala Gly Ala Val Glu Ile Ala Ile Thr 
            20                  25                  30          


Tyr Pro Ala Glu Phe Ala Lys Thr Arg Ser Gln Leu Asn Arg Arg Leu 
        35                  40                  45              


Pro Asp Ala Lys Lys Leu Pro Trp Pro Pro Phe Gly Ser Gln Trp Tyr 
    50                  55                  60                  


Ala Gly Cys Thr Thr Leu Ile Ile Gly Asn Ser Leu Lys Ala Gly Ile 
65                  70                  75                  80  


Arg Phe Val Ala Phe Asp Trp Leu Lys Ser Leu Leu Gln Asp Glu Asn 
                85                  90                  95      


Gly Gln Ile Ser Gly Pro Lys Thr Val Ile Ala Gly Phe Gly Ala Gly 
            100                 105                 110         


Phe Thr Glu Ser Leu Leu Ala Val Thr Pro Phe Glu Ser Ile Lys Thr 
        115                 120                 125             


Gln Leu Ile Asp Asp Arg Lys Ser Gln Asn Pro Arg Met Arg Gly Phe 
    130                 135                 140                 


Leu His Gly Ser Arg Val Ile Phe Gln Glu Arg Gly Val Arg Gly Phe 
145                 150                 155                 160 


Phe Gln Gly Phe Val Pro Thr Thr Ala Arg Gln Ala Ala Asn Ser Ala 
                165                 170                 175     


Thr Arg Phe Ser Ser Tyr Thr Met Leu Lys Gln Met Ala Gln Gly Tyr 
            180                 185                 190         


Val Ala Pro Gly Glu Lys Leu Gly Thr Ala Ser Thr Phe Ala Leu Gly 
        195                 200                 205             


Gly Ile Ala Gly Leu Ile Thr Val Tyr Val Thr Gln Pro Leu Asp Thr 
    210                 215                 220                 


Val Lys Thr Arg Met Gln Ser Leu Glu Ala Ser Lys Asn Tyr Lys Asn 
225                 230                 235                 240 


Ser Phe Val Cys Ala Ala Arg Ile Phe Lys Asp Glu Gly Ile Phe Thr 
                245                 250                 255     


Phe Trp Ser Gly Ala Val Pro Arg Leu Ala Arg Leu Ile Met Ser Gly 
            260                 265                 270         


Gly Ile Val Phe Thr Met Tyr Glu Lys Thr Met Asp Ala Leu Asp Gly 
        275                 280                 285             


Leu Asp Pro Glu Arg Arg Tyr Ile 
    290                 295     


<210>  47
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  47
attaagaccc gcatgcaatc                                                 20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  48
cttctcgtag acggggaaca                                                 20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  49
accttcacta gctggcgtgt                                                 20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  50
gacatccgtg ggactgaact                                                 20


<210>  51
<211>  403
<212>  PRT
<213>  Aspergillus terreus

<400>  51

Met Gly His Gly Asp Thr Glu Ser Pro Asn Pro Thr Thr Thr Thr Glu 
1               5                   10                  15      


Gly Ser Gly Gln Asn Glu Pro Glu Lys Lys Gly Arg Asp Ile Pro Leu 
            20                  25                  30          


Trp Arg Lys Cys Val Ile Thr Phe Val Val Ser Trp Met Thr Leu Val 
        35                  40                  45              


Val Thr Phe Ser Ser Thr Cys Leu Leu Pro Ala Ala Pro Glu Ile Ala 
    50                  55                  60                  


Asn Glu Phe Asp Met Thr Val Glu Thr Ile Asn Ile Ser Asn Ala Gly 
65                  70                  75                  80  


Val Leu Val Ala Met Gly Tyr Ser Ser Leu Ile Trp Gly Pro Met Asn 
                85                  90                  95      


Lys Leu Val Gly Arg Arg Thr Ser Tyr Asn Leu Ala Ile Ser Met Leu 
            100                 105                 110         


Cys Ala Cys Ser Ala Gly Thr Ala Ala Ala Ile Asn Glu Glu Met Phe 
        115                 120                 125             


Ile Ala Phe Arg Val Leu Ser Gly Leu Thr Gly Thr Ser Phe Met Val 
    130                 135                 140                 


Ser Gly Gln Thr Val Leu Ala Asp Ile Phe Glu Pro Val Tyr Arg Gly 
145                 150                 155                 160 


Thr Ala Val Gly Phe Phe Met Ala Gly Thr Leu Ser Gly Pro Ala Ile 
                165                 170                 175     


Gly Pro Cys Val Gly Gly Val Ile Val Thr Phe Thr Ser Trp Arg Val 
            180                 185                 190         


Ile Phe Trp Leu Gln Leu Gly Met Ser Gly Leu Gly Leu Val Leu Ser 
        195                 200                 205             


Leu Leu Phe Phe Pro Lys Ile Glu Gly Asn Ser Glu Lys Val Ser Thr 
    210                 215                 220                 


Ala Phe Lys Pro Thr Thr Leu Val Thr Ile Ile Ser Lys Phe Ser Pro 
225                 230                 235                 240 


Thr Asp Val Leu Lys Gln Trp Val Tyr Pro Asn Val Phe Leu Ala Asp 
                245                 250                 255     


Leu Cys Cys Gly Leu Leu Ala Ile Thr Gln Tyr Ser Ile Leu Thr Ser 
            260                 265                 270         


Ala Arg Ala Ile Phe Asn Ser Arg Phe His Leu Thr Thr Ala Leu Val 
        275                 280                 285             


Ser Gly Leu Phe Tyr Leu Ala Pro Gly Ala Gly Phe Leu Ile Gly Ser 
    290                 295                 300                 


Leu Val Gly Gly Lys Leu Ser Asp Arg Thr Val Arg Arg Tyr Ile Val 
305                 310                 315                 320 


Lys Arg Gly Phe Arg Leu Pro Gln Asp Arg Leu His Ser Gly Leu Ile 
                325                 330                 335     


Thr Leu Phe Ala Val Leu Pro Ala Gly Thr Leu Ile Tyr Gly Trp Thr 
            340                 345                 350         


Leu Gln Glu Asp Lys Gly Asp Met Val Val Pro Ile Ile Ala Ala Phe 
        355                 360                 365             


Phe Ala Gly Trp Gly Leu Met Gly Ser Phe Asn Cys Leu Asn Thr Tyr 
    370                 375                 380                 


Val Ala Gly Leu Phe His Thr Leu Ile Tyr Leu Phe Pro Leu Cys Thr 
385                 390                 395                 400 


Cys Pro Gln 
            


<210>  52
<211>  472
<212>  PRT
<213>  Aspergillus oryzae

<400>  52

Met Gly Gln Pro Asp Leu Glu Ser Gln Thr Pro Lys Thr Ile Asp Gly 
1               5                   10                  15      


Ala Thr Lys Glu Lys Glu Glu Lys Gly Ser Lys Val Glu Lys Gly Tyr 
            20                  25                  30          


Gly Leu Pro Leu Trp Arg Lys Cys Ile Ile Leu Phe Val Val Ser Trp 
        35                  40                  45              


Met Thr Leu Ala Val Thr Phe Ser Ser Thr Ser Leu Leu Pro Ala Thr 
    50                  55                  60                  


Pro Glu Ile Ala Glu Glu Phe Asn Thr Thr Thr Glu Thr Leu Asn Ile 
65                  70                  75                  80  


Thr Asn Ala Gly Val Leu Leu Ala Met Gly Phe Ser Ser Leu Ile Trp 
                85                  90                  95      


Gly Pro Leu Asn Asn Leu Ile Gly Arg Arg Leu Ser Tyr Asn Ile Ala 
            100                 105                 110         


Ile Phe Met Leu Cys Val Cys Ser Ala Ala Thr Gly Ala Ala Val Asp 
        115                 120                 125             


Leu Lys Met Phe Thr Ala Phe Arg Val Leu Ser Gly Leu Thr Gly Thr 
    130                 135                 140                 


Ser Phe Met Val Ser Gly Gln Thr Ile Leu Ala Asp Ile Phe Glu Pro 
145                 150                 155                 160 


Val Val Arg Gly Thr Ala Val Gly Phe Phe Met Ala Gly Ser Val Ser 
                165                 170                 175     


Gly Pro Ala Ile Gly Pro Cys Ile Gly Gly Leu Ile Val Thr Phe Ser 
            180                 185                 190         


Ser Trp Arg Asn Ile Tyr Trp Leu Gln Val Gly Met Thr Gly Phe Gly 
        195                 200                 205             


Leu Val Leu Ala Ile Leu Phe Val Pro Glu Ile Lys Gln Glu Ser Lys 
    210                 215                 220                 


Glu Glu Pro Glu Glu Lys Glu Lys Arg Thr Val Leu Ser Ala Leu Arg 
225                 230                 235                 240 


Leu Phe Asn Pro Leu Arg Ile Phe Arg Gln Trp Val Tyr Pro Asn Val 
                245                 250                 255     


Phe Phe Ser Asp Leu Thr Cys Gly Leu Leu Ala Thr Phe Gln Tyr Ser 
            260                 265                 270         


Leu Leu Thr Ser Ala Arg Ser Ile Phe Asn Pro Arg Phe His Leu Thr 
        275                 280                 285             


Thr Ala Leu Ile Ser Gly Leu Phe Tyr Leu Ala Pro Gly Ala Gly Phe 
    290                 295                 300                 


Leu Ile Gly Ser Ile Ile Gly Gly Lys Leu Ser Asp Arg Thr Val Arg 
305                 310                 315                 320 


Lys Tyr Ile Val Arg Arg Gly Phe Arg Leu Pro Gln Asp Arg Leu Asn 
                325                 330                 335     


Ser Gly Leu Val Thr Leu Phe Ala Val Leu Pro Val Ser Ala Leu Ile 
            340                 345                 350         


Tyr Gly Trp Thr Leu Gln Glu Glu Lys Gly Gly Met Val Val Pro Ile 
        355                 360                 365             


Leu Ala Ala Phe Phe Ala Gly Trp Gly Leu Met Gly Ser Phe Asn Thr 
    370                 375                 380                 


Leu Asn Thr Tyr Val Ala Glu Ala Leu Pro His Lys Arg Ser Glu Val 
385                 390                 395                 400 


Ile Ala Gly Lys Tyr Ile Ile Gln Tyr Ile Phe Ser Ala Gly Ser Ser 
                405                 410                 415     


Ala Leu Val Val Pro Ile Ile Asn Ala Ile Gly Val Gly Trp Thr Phe 
            420                 425                 430         


Thr Ile Cys Val Ile Phe Ser Ile Ile Gly Gly Leu Leu Thr Met Ala 
        435                 440                 445             


Thr Ala Arg Trp Gly Leu Asp Met Gln Gln Trp Val Glu Arg Lys Phe 
    450                 455                 460                 


Arg Ile His Asp Lys Pro Gly Phe 
465                 470         


<210>  53
<211>  462
<212>  PRT
<213>  Aspergillus flavus

<400>  53

Met Gly Gln Pro Asp Leu Glu Ser Gln Thr Pro Lys Thr Ile Asp Gly 
1               5                   10                  15      


Ala Thr Lys Glu Lys Glu Glu Lys Gly Ser Lys Val Glu Lys Gly Tyr 
            20                  25                  30          


Gly Leu Pro Leu Trp Arg Lys Cys Ile Ile Leu Phe Val Val Ser Trp 
        35                  40                  45              


Met Thr Leu Ala Val Thr Phe Ser Ser Thr Ser Leu Leu Pro Ala Thr 
    50                  55                  60                  


Pro Glu Ile Ala Glu Glu Phe Asn Thr Thr Thr Glu Thr Leu Asn Ile 
65                  70                  75                  80  


Thr Asn Ala Gly Val Leu Leu Ala Met Gly Phe Ser Ser Leu Ile Trp 
                85                  90                  95      


Gly Pro Leu Asn Asn Leu Ile Gly Arg Arg Leu Ser Tyr Asn Ile Ala 
            100                 105                 110         


Ile Phe Met Leu Cys Val Cys Ser Ala Ala Thr Gly Ala Ala Val Asp 
        115                 120                 125             


Leu Lys Met Phe Thr Ala Phe Arg Val Leu Ser Gly Leu Thr Gly Thr 
    130                 135                 140                 


Ser Phe Met Val Ser Gly Gln Thr Ile Leu Ala Asp Ile Phe Glu Pro 
145                 150                 155                 160 


Val Val Arg Gly Thr Ala Val Gly Phe Phe Met Ala Gly Ser Val Ser 
                165                 170                 175     


Gly Pro Ala Ile Gly Pro Cys Ile Gly Gly Leu Ile Val Thr Phe Ser 
            180                 185                 190         


Ser Trp Arg Asn Ile Tyr Trp Leu Gln Val Gly Met Thr Gly Phe Gly 
        195                 200                 205             


Leu Val Leu Ala Ile Leu Phe Val Pro Glu Ile Lys Gln Glu Ser Lys 
    210                 215                 220                 


Glu Glu Pro Glu Glu Lys Glu Lys Arg Thr Val Leu Ser Ala Leu Arg 
225                 230                 235                 240 


Leu Phe Asn Pro Leu Arg Ile Phe Arg Gln Trp Val Tyr Pro Asn Val 
                245                 250                 255     


Phe Phe Ser Asp Leu Thr Cys Gly Leu Leu Ala Thr Phe Gln Tyr Ser 
            260                 265                 270         


Leu Leu Thr Ser Ala Arg Ser Ile Phe Asn Pro Arg Phe His Leu Thr 
        275                 280                 285             


Thr Ala Leu Ile Ser Gly Leu Phe Tyr Leu Ala Pro Gly Ala Gly Phe 
    290                 295                 300                 


Leu Ile Gly Ser Ile Ile Gly Gly Lys Leu Ser Asp Arg Thr Val Arg 
305                 310                 315                 320 


Lys Tyr Ile Val Arg Arg Gly Phe Arg Leu Pro Gln Asp Arg Leu Asn 
                325                 330                 335     


Ser Gly Leu Val Thr Leu Phe Ala Val Leu Pro Val Ser Ala Leu Ile 
            340                 345                 350         


Tyr Gly Trp Thr Leu Gln Glu Glu Lys Gly Gly Met Val Val Pro Ile 
        355                 360                 365             


Leu Ala Ala Phe Phe Ala Gly Trp Gly Leu Met Gly Ser Phe Asn Thr 
    370                 375                 380                 


Leu Asn Thr Tyr Val Ala Glu Ala Leu Pro His Lys Arg Ser Glu Val 
385                 390                 395                 400 


Ile Ala Gly Lys Tyr Ile Ile Gln Tyr Ile Phe Ser Ala Gly Ser Ser 
                405                 410                 415     


Ala Leu Val Val Pro Ile Ile Asn Ala Ile Gly Val Gly Trp Thr Phe 
            420                 425                 430         


Thr Ile Cys Met Phe Asp Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
        435                 440                 445             


Leu Leu Leu Leu Phe Cys Leu Leu Arg Glu Val Ile Cys Asp 
    450                 455                 460         


<210>  54
<211>  455
<212>  PRT
<213>  Neosartorya fischeri 

<400>  54

Met Pro Asp Leu Asp Pro Glu Lys Ser Thr Gln Asp Thr Cys His Leu 
1               5                   10                  15      


Pro Leu Trp Arg Lys Cys Ile Ile Leu Phe Val Val Ser Trp Met Thr 
            20                  25                  30          


Phe Val Val Thr Phe Ser Ser Thr Ser Leu Leu Pro Ala Thr Pro Glu 
        35                  40                  45              


Ile Ala Ala Glu Phe Asp Thr Thr Pro Glu Leu Leu Asn Val Thr Asn 
    50                  55                  60                  


Ala Gly Val Leu Leu Ala Met Gly Phe Ser Ser Leu Ile Trp Gly Pro 
65                  70                  75                  80  


Val Thr Ala Leu Leu Gly Arg Arg Val Ala Tyr Asn Ile Ala Ile Gly 
                85                  90                  95      


Ala Leu Cys Gly Cys Ser Val Gly Thr Ala Val Ala Gly Gly Ser Ser 
            100                 105                 110         


Val Phe Thr Val Phe Arg Val Leu Gly Gly Leu Thr Gly Thr Ser Phe 
        115                 120                 125             


Met Val Gln Gly Gln Thr Ile Leu Ala Asp Ile Phe Glu Ala Lys Val 
    130                 135                 140                 


Arg Gly Thr Ala Val Gly Phe Phe Met Ala Gly Thr Val Thr Gly Pro 
145                 150                 155                 160 


Ala Ile Gly Pro Cys Ile Gly Gly Leu Val Val Thr Phe Ala Arg Trp 
                165                 170                 175     


Arg Val Ile Phe Trp Val Gln Val Ala Met Ala Gly Leu Gly Leu Ala 
            180                 185                 190         


Leu Ser Leu Leu Phe Val Pro Glu Val Lys Lys Arg Glu Ala Glu Gly 
        195                 200                 205             


Glu Gly Val Pro Arg Pro Ser Ser Leu Arg Glu Val Leu Ala Met Phe 
    210                 215                 220                 


Asn Pro Val Arg Ile Phe Arg Gln Trp Leu Tyr Pro Asn Val Phe Leu 
225                 230                 235                 240 


Cys Asp Leu Thr Cys Gly Leu Leu Ala Ile Phe His Tyr Gly Leu Leu 
                245                 250                 255     


Thr Ser Ala Arg Glu Ile Phe Asn Pro Arg Phe Asn Leu Thr Ser Ala 
            260                 265                 270         


Leu Val Ser Gly Leu Phe Tyr Leu Ala Pro Gly Ala Gly Phe Leu Leu 
        275                 280                 285             


Gly Ser Ile Leu Gly Gly Arg Leu Ser Asp Arg Thr Val Lys Arg Tyr 
    290                 295                 300                 


Ile Ala Arg Arg Gly Gly Leu Arg Leu Pro Gln Asp Arg Leu Asn Ser 
305                 310                 315                 320 


Gly Leu Ala Thr Leu Cys Gly Val Leu Pro Val Ala Val Leu Val Tyr 
                325                 330                 335     


Gly Trp Thr Leu Glu Lys Arg Ala Gly Gly Met Ala Val Pro Ile Ile 
            340                 345                 350         


Ala Ala Phe Trp Ala Gly Val Gly Leu Met Gly Ser Phe Asn Gly Leu 
        355                 360                 365             


Asn Thr Tyr Ala Ala Glu Ala Ile Pro Glu Arg Arg Ser Glu Val Ile 
    370                 375                 380                 


Ser Gly Lys Tyr Ile Val Gln Tyr Leu Cys Ser Ala Gly Ser Ser Ala 
385                 390                 395                 400 


Ala Val Val Pro Leu Ile Lys Val Ile Gly Val Gly Trp Thr Phe Thr 
                405                 410                 415     


Ile Cys Val Val Leu Ser Leu Leu Gly Gly Gly Phe Val Phe Cys Ile 
            420                 425                 430         


Thr Arg Trp Gly Arg Ala Met Gln Leu Trp Ala Glu Glu Lys Phe Leu 
        435                 440                 445             


Leu Asp Gly Lys Ser Gly Leu 
    450                 455 


<210>  55
<211>  452
<212>  PRT
<213>  Penicillium chrysogenum

<400>  55

Met Pro Arg Asp Asp Leu Ala Leu Lys Pro Gln Pro Ser Asn Ala Tyr 
1               5                   10                  15      


Gly Ile Pro Thr Trp Arg Lys Cys Leu Ile Leu Phe Val Val Ser Trp 
            20                  25                  30          


Met Thr Leu Ala Val Thr Phe Ser Ser Thr Ser Leu Leu Pro Ala Thr 
        35                  40                  45              


Pro Glu Ile Ala Thr Glu Phe Ser Thr Thr Ser Glu Ile Leu Asn Val 
    50                  55                  60                  


Thr Asn Ala Gly Val Leu Ile Ala Met Gly Phe Ser Ser Phe Ile Trp 
65                  70                  75                  80  


Gly Pro Ile Thr Asn Leu Phe Gly Arg Arg Asn Ala Tyr Asn Ala Ala 
                85                  90                  95      


Ile Leu Val Leu Cys Ala Cys Ser Ala Gly Thr Ala Ala Ala Ile Asn 
            100                 105                 110         


Leu His Met Phe Ile Ala Met Arg Ile Leu Gly Gly Phe Thr Gly Thr 
        115                 120                 125             


Phe Phe Met Val Ala Gly Gln Thr Ile Leu Ala Asp Ile Phe Glu Pro 
    130                 135                 140                 


Thr Val Arg Gly Thr Ala Val Gly Cys Phe Met Val Gly Ser Val Ser 
145                 150                 155                 160 


Gly Pro Ala Ile Gly Pro Cys Ile Gly Gly Ile Ile Val Thr Phe Ala 
                165                 170                 175     


Gln Trp Arg Ile Ile Tyr Trp Leu Gln Phe Ala Met Thr Leu Leu Gly 
            180                 185                 190         


Leu Val Leu Ser Leu Leu Phe Val Pro Ser Val Gln Glu Lys Ser Arg 
        195                 200                 205             


Asp Ser Asp Lys Pro Leu Lys Leu Cys Thr Val Ile Ser Met Phe Asn 
    210                 215                 220                 


Pro Met Arg Ile Phe Arg Arg Phe Val Tyr Pro Asn Val Phe Leu Ala 
225                 230                 235                 240 


Cys Leu Thr Cys Gly Leu Leu Ser Thr Phe Gln Tyr Ala Leu Leu Thr 
                245                 250                 255     


Ser Ala Arg Ser Ile Phe Asn Pro Arg Phe Asn Leu Thr Ser Pro Leu 
            260                 265                 270         


Val Ser Gly Leu Phe Tyr Leu Ser Pro Gly Ile Gly Phe Leu Ile Gly 
        275                 280                 285             


Ser Val Val Gly Gly Lys Leu Ser Asp Arg Ala Val Lys Lys Trp Ile 
    290                 295                 300                 


Val Lys Arg Asn Gly Val Arg Leu Pro Gln Asp Arg Leu Asn Ser Gly 
305                 310                 315                 320 


Leu Ala Thr Leu Phe Gly Val Leu Pro Gly Ala Thr Leu Ile Tyr Cys 
                325                 330                 335     


Trp Thr Leu Glu Glu Glu Val Gly Gly Met Val Val Pro Ile Ile Ala 
            340                 345                 350         


Ala Phe Phe Ala Gly Val Gly Leu Leu Gly Ala Phe Asn Gly Leu Asn 
        355                 360                 365             


Thr Tyr Ser Ala Glu Val Met Pro Gln Ala Arg Ser Glu Val Ile Ser 
    370                 375                 380                 


Ala Lys Tyr Met Val Gln Tyr Ile Phe Ala Ala Ala Ala Thr Ala Ala 
385                 390                 395                 400 


Val Glu Pro Val Ile Gly Ala Ile Gly Val Gly Trp Thr Phe Thr Ile 
                405                 410                 415     


Cys Val Phe Phe Ala Ile Ala Ser Gly Phe Ile Val Leu Ala Ile Thr 
            420                 425                 430         


Lys Trp Gly Leu Asp Met Gln Arg Trp Phe Glu Lys Lys Phe Ser Leu 
        435                 440                 445             


Asp Ala Lys Thr 
    450         


<210>  56
<211>  426
<212>  PRT
<213>  Aspergillus fumigatus

<400>  56

Met Ala Asp Leu Asp Pro Glu Lys Asn Thr Arg Asn Thr Trp His Leu 
1               5                   10                  15      


Pro Leu Trp Arg Lys Cys Ile Ile Leu Val Val Val Ser Trp Met Ala 
            20                  25                  30          


Phe Val Val Thr Phe Ser Ser Thr Ser Leu Leu Pro Ala Thr Pro Glu 
        35                  40                  45              


Ile Ala Ala Glu Phe Asp Thr Thr Pro Glu Ile Leu Asn Ile Ile Asn 
    50                  55                  60                  


Ala Gly Val Leu Leu Ala Met Gly Phe Ser Ser Leu Ile Trp Gly Pro 
65                  70                  75                  80  


Leu Thr Ala Leu Leu Gly Arg Arg Val Ala Tyr Asn Ile Ala Ile Ala 
                85                  90                  95      


Ala Leu Cys Gly Cys Ser Val Gly Thr Ala Leu Ala Gly Gly Ser Ser 
            100                 105                 110         


Val Phe Ala Val Phe Arg Val Leu Gly Gly Leu Thr Gly Thr Ser Phe 
        115                 120                 125             


Met Val Gln Gly Gln Thr Ile Leu Ala Asp Ile Phe Glu Ala Lys Val 
    130                 135                 140                 


Arg Gly Thr Ala Val Gly Phe Phe Met Ala Gly Thr Val Thr Gly Pro 
145                 150                 155                 160 


Ala Ile Gly Pro Cys Ile Gly Gly Leu Val Val Thr Phe Ala His Trp 
                165                 170                 175     


Arg Val Ile Phe Trp Val Gln Val Gly Met Ala Gly Leu Gly Leu Val 
            180                 185                 190         


Leu Ser Leu Phe Phe Val Pro Glu Val Lys Lys Arg Glu Ala Glu Gly 
        195                 200                 205             


Glu Gly Glu Gly Val Pro Arg Arg Ser Ser Leu Arg Glu Val Leu Ala 
    210                 215                 220                 


Met Phe Asn Pro Val Arg Ile Phe Arg Gln Trp Leu Tyr Pro Asn Val 
225                 230                 235                 240 


Phe Leu Cys Arg Leu Thr Arg Gln Asp Val Thr Cys Gly Leu Leu Ala 
                245                 250                 255     


Ile Phe Gln Tyr Gly Leu Leu Thr Ser Ala Arg Glu Ile Phe Asn Pro 
            260                 265                 270         


Arg Phe Asn Leu Thr Ser Ala Leu Val Ser Gly Leu Phe Tyr Leu Val 
        275                 280                 285             


Pro Gly Ala Gly Phe Leu Leu Gly Ser Ile Ile Gly Gly Arg Leu Ser 
    290                 295                 300                 


Asp Arg Thr Val Lys Arg Tyr Ile Ala Arg Arg Gly Gly Leu Arg Leu 
305                 310                 315                 320 


Pro Gln Asp Arg Leu Asn Ser Gly Leu Ala Met Leu Cys Gly Val Leu 
                325                 330                 335     


Pro Val Ala Val Leu Val Tyr Gly Trp Thr Leu Glu Lys Arg Ala Gly 
            340                 345                 350         


Gly Met Ala Val Pro Ile Ile Ala Ala Phe Trp Ala Gly Val Gly Leu 
        355                 360                 365             


Met Gly Ser Phe Asn Gly Leu Asn Thr Tyr Ala Ala Glu Ala Ile Pro 
    370                 375                 380                 


Glu Arg Arg Ser Glu Val Ile Ser Gly Lys Tyr Ile Leu Gln Tyr Leu 
385                 390                 395                 400 


Cys Ser Ala Gly Ser Ser Ala Ala Val Val Pro Leu Val Lys Val Ile 
                405                 410                 415     


Gly Val Gly Trp Thr Phe Thr Ile Cys Glu 
            420                 425     


<210>  57
<211>  1488
<212>  PRT
<213>  Aspergillus nidulans

<400>  57

Met Thr Asp Val Ala Ala Leu Glu Ala Glu Val Lys Glu Phe Lys Leu 
1               5                   10                  15      


Gln Val Asp Pro Asp Asn Thr Glu Leu Gln Ser Leu Lys Ala Glu Leu 
            20                  25                  30          


Glu Glu Leu Ile Asn Leu Thr Glu Thr Ser Ile Ala Glu Leu Arg Pro 
        35                  40                  45              


Ala Thr Pro Gln Pro Thr Thr Ala Pro Ala Lys Leu Lys Gly Ser Arg 
    50                  55                  60                  


Asp Asp Asn Ala Ser Lys Pro Gly Tyr Arg Asn Ser Thr Ala Glu Gln 
65                  70                  75                  80  


Thr Asp Asp Asn Thr Asn Ser Gly Pro Ala Ser Phe Ser Val Asn Glu 
                85                  90                  95      


His Val Leu Ala Arg Trp Val Ser Gly Asp Asn Ser Phe Tyr Pro Ala 
            100                 105                 110         


Arg Ile Thr Ser Ile Thr Gly Ser Ser Ser Asn Pro Val Tyr Ile Val 
        115                 120                 125             


Ser Phe Lys Ser Tyr Gly Thr Val Glu Ser Leu Thr Ala Lys Asp Leu 
    130                 135                 140                 


Lys Pro Ile Ser Asn Ser Asp Ser Arg Lys Arg Lys Ala Asp Gly Ser 
145                 150                 155                 160 


Pro Gly Ser Ser Asn His Ser Pro Val Pro Gln Pro Pro His Ala Ser 
                165                 170                 175     


Val Ile Ser Ala Ala Ala Asp Ile Asn Pro Ala Leu Ala Asn Gln Ala 
            180                 185                 190         


Arg Lys Glu Pro Ser Lys Ala Thr Asp Gly Pro Ala Arg Pro Ala Lys 
        195                 200                 205             


Val Ser Arg Lys Val Lys Ala Asn Lys Glu Leu Glu Ala Gly Lys Asn 
    210                 215                 220                 


Lys Trp Lys Asp Phe Ala Ser Lys Thr Lys Ile Gly Arg Lys Asp Ser 
225                 230                 235                 240 


Met Phe Arg Thr Gly Glu Gly Val Asn Ala Arg Asp Ala Lys Asp Ala 
                245                 250                 255     


Ile Leu Ile Arg Ser Asn Val Leu Val Thr Ser Pro Val Arg Asn Val 
            260                 265                 270         


Ala Pro Ser Asp Val Leu Met Ser Ala Asn Thr Arg His Ala Thr Val 
        275                 280                 285             


Lys Ser Lys Ser Ala Lys Gly Arg Leu Ser Ser Ile Gly Ile Leu Cys 
    290                 295                 300                 


Pro Glu Gln Val Leu Ala Glu Asn Gln Arg Leu Arg Ala Gln Ser Ala 
305                 310                 315                 320 


Ser Ser Ala Asn Thr Pro Glu Ala Arg Pro Gly Ala Glu Pro Ser His 
                325                 330                 335     


Ser Arg Leu Cys Ala Asp Gly Ser Asp Glu Val Glu Ser Glu Asp Glu 
            340                 345                 350         


Gly Asn Thr Gly Val Arg Asn Pro Ile Ile Gly Asp Arg Ala Trp Phe 
        355                 360                 365             


His Ala Tyr Asp Pro Ser Ala Pro Pro Ile Phe Val Gly Glu Ala Ala 
    370                 375                 380                 


Cys Thr Ala Phe Ala Thr Arg Phe Arg Gln Phe Leu Thr Gly Ser Asn 
385                 390                 395                 400 


Ala Thr Ala His Ile Arg Arg Thr Gln Tyr Val Lys Glu Glu Asn Ile 
                405                 410                 415     


Ala Leu Ala Asn Ala Gly Glu Ile Arg Trp Pro Ser Leu Gln Gln Ala 
            420                 425                 430         


Arg Leu Leu Val Gln Ile Ala Ile Arg Gln Ile Ser Cys Ile Tyr His 
        435                 440                 445             


Val Leu Leu Arg Lys Ser Thr Leu Asp Lys Leu Glu Glu Ile Tyr Arg 
    450                 455                 460                 


Thr Gly Asp Phe Glu Cys Thr Val Asn Gln Cys Lys Phe Phe Ala Leu 
465                 470                 475                 480 


Phe Ala Phe Gly Glu Ala Tyr Ser Met Arg Ser Glu Pro Ala Ser Gly 
                485                 490                 495     


Ser Arg Val Pro Gly Thr Ser Tyr Phe Ala Arg Ser Leu Ser Leu Val 
            500                 505                 510         


Gln Val Leu Pro Glu Arg Thr Ser Ile Thr His Leu Glu Thr Leu Leu 
        515                 520                 525             


Leu Leu Ser Leu Phe Ser Tyr Tyr Leu Asn Arg Arg His Ser Ala Tyr 
    530                 535                 540                 


Val Leu Ile Gly Ser Ala Met Arg Leu Gly Leu Cys Ile Gly Leu Asn 
545                 550                 555                 560 


His Asn Ile Pro Glu Ser Gln Leu Ile Asp Pro Val Glu Arg Gln His 
                565                 570                 575     


Arg Val Arg Ile Trp Trp Thr Ile Tyr Ile Phe Asp Arg Met Trp Ala 
            580                 585                 590         


Ser Lys Met Gly Leu Pro Ser Gln Ile Leu Asp Asp Asp Ile His Leu 
        595                 600                 605             


Asp Met Pro Ser Ser Thr Leu Pro Lys Gln Ile Tyr Glu Glu Gln Phe 
    610                 615                 620                 


Thr Asp Ala Glu Tyr Ile Lys Ala Asn Ile Asn Leu Ala Arg Ile Val 
625                 630                 635                 640 


Gly Glu Thr Thr Ala Lys Val Tyr Ser Arg Arg Lys Tyr Asn Glu Thr 
                645                 650                 655     


Phe Leu Gln Arg Val Gln Lys Leu Leu Lys Ala Leu Lys Asn Trp Val 
            660                 665                 670         


Asp Thr Leu Pro Glu His Leu Arg Leu Asn Val Glu Asp Pro Glu Met 
        675                 680                 685             


Asn Thr Lys Gln Val Thr Ser Ile His Leu Ala Phe Asn Gln Val Phe 
    690                 695                 700                 


Leu Pro Gly Leu Arg Pro Tyr Pro Thr Lys Ser Thr Asn Ala Asp Ile 
705                 710                 715                 720 


Gln Cys Val Ile Leu Thr Thr Arg Pro Thr Leu Leu His Leu Leu Arg 
                725                 730                 735     


Leu Thr Glu Thr Gly Asn Thr Thr Thr Ser Ser Thr Thr Thr Thr Lys 
            740                 745                 750         


Glu Thr Ile Ser Gln Pro Leu Gln Thr Leu Gly Glu Ala Cys Ile His 
        755                 760                 765             


Ala Ala Arg His Ser His Ser Leu Ile Leu Thr Lys Trp Ile Asn Gly 
    770                 775                 780                 


Ser Leu Pro Val Phe Gly Tyr Phe His Ala His Tyr Leu Phe Ser Ser 
785                 790                 795                 800 


Ser Leu Val Leu Ala Met Ser Ala Phe Val Pro Leu Pro Leu Gly Ser 
                805                 810                 815     


Pro Ala Asp Leu Asn Ala Phe Glu Thr Gly Leu Glu Val Leu Ala Ser 
            820                 825                 830         


Met Ser Glu Asn Gly Asn Leu Ala Ala Ser Glu Phe Tyr His Asn Leu 
        835                 840                 845             


Val Arg Val Lys Glu Cys Leu Asp Ser Trp Arg Ala Lys Lys Gly Leu 
    850                 855                 860                 


Ala Asn Gly Ser Gly Ser Ala Ser His Asn Arg Gly Ser Gln Ser Gln 
865                 870                 875                 880 


Ser Gln Gly Pro Phe Gly Thr Ala Thr Gly Ser Ser Ala Pro Leu Ser 
                885                 890                 895     


Pro Ser Asn Ser Leu Val Arg Pro Ala Gly Gln Gly Gln Asn Ser Met 
            900                 905                 910         


Pro Ala Ser Leu Ser Gly Pro Ile Pro Gly Leu Leu Pro Thr Tyr Asn 
        915                 920                 925             


Asn Thr Ser Ile Ile Ala Gln Asn Pro Asn His Asn Pro Thr Ser Ser 
    930                 935                 940                 


Ala Pro Cys Ala Leu Asp Gly Asn Asp Ser Ser Gln Ser Gln Val Gln 
945                 950                 955                 960 


Gly Arg Val Ala Gly Gly Phe Thr Thr Ala Met Ala Phe Met Glu Pro 
                965                 970                 975     


Thr Met Gln Asp Phe Leu Ala Gln Thr Asp Leu Asp Leu Gly Leu Leu 
            980                 985                 990         


Asn Pro Val Glu Thr Phe Met Asp  His Ile Lys Leu Gly  Leu Glu Val 
        995                 1000                 1005             


Thr Met  Glu Asp Pro Glu Lys  Val Ala Ser Ser Ser  Ser Ser Pro 
    1010                 1015                 1020             


Gly Thr  Arg Ser Ala Ser Pro  Ser Pro Ser Thr Val  Arg Lys Pro 
    1025                 1030                 1035             


Pro Asn  Thr His Thr Ser Gly  Phe Leu Leu Pro Lys  Trp His Lys 
    1040                 1045                 1050             


Leu Ile  Ile Leu Phe Val Val  Ser Trp Met Thr Leu  Ala Val Thr 
    1055                 1060                 1065             


Phe Ser  Ser Thr Ser Leu Leu  Pro Ala Thr Pro Glu  Ile Ala Leu 
    1070                 1075                 1080             


Glu Phe  Asn Thr Thr Thr Glu  Ile Leu Asn Ile Thr  Asn Ala Gly 
    1085                 1090                 1095             


Val Leu  Leu Ala Met Gly Leu  Ser Thr Leu Phe Trp  Gly Pro Leu 
    1100                 1105                 1110             


Thr Ile  Leu Ile Gly Arg Arg  Leu Ser Tyr Asn Ile  Ala Val Ala 
    1115                 1120                 1125             


Val Leu  Val Leu Cys Ser Gly  Leu Thr Ala Gly Ser  Arg Ser Met 
    1130                 1135                 1140             


Gly Met  Phe Thr Ala Cys Arg  Ile Leu Gly Gly Phe  Thr Gly Thr 
    1145                 1150                 1155             


Ser Phe  Met Val Ser Gly Gln  Thr Val Leu Ala Asp  Ile Phe Glu 
    1160                 1165                 1170             


Pro Glu  Ile Arg Gly Thr Ala  Val Gly Phe Phe Met  Leu Gly Thr 
    1175                 1180                 1185             


Val Thr  Gly Pro Ala Ile Gly  Pro Cys Ile Gly Gly  Ile Ile Val 
    1190                 1195                 1200             


Thr Phe  Ala Ser Trp Arg Asn  Ile Tyr Trp Leu Gln  Thr Ala Met 
    1205                 1210                 1215             


Ala Gly  Leu Gly Leu Val Leu  Ser Leu Ile Phe Val  Pro Glu Val 
    1220                 1225                 1230             


Gln Gln  Asp Ile Ser Ser Ser  Asp Thr Gln Lys Gln  Lys Glu Lys 
    1235                 1240                 1245             


Glu Lys  Ile Thr Leu Arg Tyr  Ala Leu Lys Val Phe  Asn Pro Val 
    1250                 1255                 1260             


Arg Val  Phe Arg Leu Trp Leu  Tyr Pro Asn Leu Leu  Phe Ser Phe 
    1265                 1270                 1275             


Leu Thr  Cys Gly Leu Leu Ala  Thr Tyr Leu Tyr Ala  Leu Leu Ser 
    1280                 1285                 1290             


Ser Ala  Arg Thr Ile Phe Asn  Pro Arg Phe Asn Leu  Thr Ser Ala 
    1295                 1300                 1305             


Leu Val  Ser Gly Leu Phe Tyr  Leu Ala Pro Gly Ser  Gly Phe Leu 
    1310                 1315                 1320             


Val Gly  Ser Val Leu Gly Gly  Arg Leu Ser Asp Leu  Thr Val Arg 
    1325                 1330                 1335             


Lys Tyr  Ile Ala Arg Arg Gly  Phe Arg Leu Pro Gln  Asp Arg Leu 
    1340                 1345                 1350             


Asn Ser  Gly Leu Ile Met Leu  Ser Leu Val Leu Pro  Gly Ala Thr 
    1355                 1360                 1365             


Leu Val  Tyr Ala Trp Thr Leu  Asp Gln Glu Val Gly  Gly Met Ala 
    1370                 1375                 1380             


Met Pro  Ile Ile Ala Gly Phe  Val Gly Gly Val Gly  Leu Met Gly 
    1385                 1390                 1395             


Ser Phe  Asn Gly Leu Asn Thr  Tyr Ala Ala Glu Ala  Leu Pro Ser 
    1400                 1405                 1410             


His Arg  Ala Glu Val Ile Ala  Gly Lys Tyr Ile Ile  Gln Tyr Ile 
    1415                 1420                 1425             


Phe Ser  Ala Gly Ala Ser Ala  Leu Val Val Pro Leu  Val Asp Lys 
    1430                 1435                 1440             


Ile Gly  Val Gly Trp Thr Phe  Thr Ile Ser Ala Phe  Phe Thr Leu 
    1445                 1450                 1455             


Thr Gly  Ala Val Leu Val Leu  Leu Ile Ala Arg Trp  Gly Ile Asp 
    1460                 1465                 1470             


Met Gln  Arg Trp Val Glu Arg  Arg Val Leu Leu Pro  Glu Lys Ser 
    1475                 1480                 1485             


<210>  58
<211>  455
<212>  PRT
<213>  Talaromyces stipitatus 

<400>  58

Met Gly Ser Ser Thr His Ser Glu Pro Thr Asp Leu Pro Thr Pro Pro 
1               5                   10                  15      


Pro Thr Ser Pro Lys Val Val Val Gly Tyr Asp Leu Pro Thr Trp Arg 
            20                  25                  30          


Lys Tyr Leu Ile Leu Phe Val Ile Ser Trp Leu Thr Leu Val Val Thr 
        35                  40                  45              


Phe Ser Ser Thr Ser Met Leu Ile Ala Thr Pro Glu Ile Ala Ser Asp 
    50                  55                  60                  


Leu Ser Thr Thr Pro Glu Ile Leu Asp Val Thr Asn Ala Gly Val Leu 
65                  70                  75                  80  


Val Ala Met Gly Leu Ser Ser Leu Ile Trp Ser Pro Leu Ser Asp Leu 
                85                  90                  95      


Phe Gly Arg Arg Lys Ile Tyr Asp Val Ala Ile Phe Phe Met Phe Val 
            100                 105                 110         


Pro Ser Ile Gly Ala Ala Val Ala Pro Asn Leu Ala Ala Phe Thr Ala 
        115                 120                 125             


Met Arg Leu Val Gly Gly Leu Thr Gly Thr Tyr Phe Met Val Ala Gly 
    130                 135                 140                 


Gln Thr Val Ile Thr Asp Ile Phe Glu Pro Leu Tyr Arg Gly Gln Ala 
145                 150                 155                 160 


Thr Gly Phe Phe Met Val Gly Ser Val Ala Gly Pro Ala Leu Gly Pro 
                165                 170                 175     


Cys Ile Gly Gly Val Ile Val Thr Phe Ser His Trp Arg Asp Ile Tyr 
            180                 185                 190         


Trp Leu Gln Ala Ala Met Ser Gly Phe Gly Leu Val Leu Ser Ile Ile 
        195                 200                 205             


Val Ile Pro Ser Ile Lys Arg Glu Val Glu Val Val His Val Ala Gly 
    210                 215                 220                 


Ala Gln Lys Leu Ser Leu Tyr Lys Thr Leu Gln Lys Phe Asn Pro Leu 
225                 230                 235                 240 


Gly Val Phe Arg Gln Leu Leu Ser Pro Asn Ile Leu Leu Ala Asp Val 
                245                 250                 255     


Thr Cys Gly Cys Leu Ala Val Thr Gln Tyr Gly Ile Leu Thr Ser Val 
            260                 265                 270         


Arg His Val Ile Asn Pro Arg Phe Asn Leu Thr Thr Pro Leu Ile Ser 
        275                 280                 285             


Gly Ile Phe Tyr Ile Ala Pro Gly Ala Gly Phe Phe Val Gly Ser Ile 
    290                 295                 300                 


Val Gly Gly Arg Leu Ser Asp Arg Thr Val Arg Arg Tyr Ile Ala Lys 
305                 310                 315                 320 


Arg Asn Gly Ile Arg Leu Pro Gly Asp Arg Leu Asn Ser Gly Leu Ile 
                325                 330                 335     


Gly Leu Phe Val Ile Leu Pro Ile Ser Leu Leu Leu Leu Gly Trp Gly 
            340                 345                 350         


Leu Gln Glu Gly Ile Gly Gly Leu Ala Leu Pro Ile Val Ala Ala Phe 
        355                 360                 365             


Trp Ala Gly Val Gly Leu Met Gly Thr Phe Asn Ala Leu Asn Thr Tyr 
    370                 375                 380                 


Thr Ala Glu Val Asn Pro Ala Lys Lys Ala Glu Val Ile Cys Thr Lys 
385                 390                 395                 400 


Tyr Ile Val Gln Tyr Leu Phe Gly Ala Gly Ser Ser Ala Ala Ile Val 
                405                 410                 415     


Pro Leu Ile Asp Ala Ile Gly Val Gly Trp Ser Phe Thr Phe Leu Val 
            420                 425                 430         


Ala Leu Asp Phe Ile Gly Gly Gly Met Val Leu Leu Ile Thr Arg Val 
        435                 440                 445             


Trp Thr Lys Val Pro Asn Glu 
    450                 455 


