               SEQUENCE LISTING

<110> Okairos AG

<120> Improved poxviral vaccines

<150> PCT/EP2013/055409
<151> 15-Mar-2013

<160> 11

<170> BiSSAP 1.0

<210> 1
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..232
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 1
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                   15    
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                   25                  30        
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                   40                  45            
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                   55                  60                
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                   70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                   90                  95    
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                  105                110        
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                  120                125            
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                  135                140                
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                  150                155                  160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                  170                175    
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                  185                190        
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                  200                205            
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
    210                  215                220                
Gln Asp Leu Gly Pro Val Pro Met 
225                  230        

<210> 2
<211> 699
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..699
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 2
atgcacagga ggagaagcag gagctgtcgg gaagatcaga agccagtcat ggatgaccag      60

cgcgacctta tctccaacaa tgagcaactg cccatgctgg gccggcgccc tggggccccg     120

gagagcaagt gcagccgcgg agccctgtac acaggctttt ccatcctggt gactctgctc     180

ctcgctggcc aggccaccac cgcctacttc ctgtaccagc agcagggccg gctggacaaa     240

ctgacagtca cctcccagaa cctgcagctg gagaacctgc gcatgaagct tcccaagcct     300

cccaagcctg tgagcaagat gcgcatggcc accccgctgc tgatgcaggc gctgcccatg     360

ggagccctgc cccaggggcc catgcagaat gccaccaagt atggcaacat gacagaggac     420

catgtgatgc acctgctcca gaatgctgac cccctgaagg tgtacccgcc actgaagggg     480

agcttcccgg agaacctgag acaccttaag aacaccatgg agaccataga ctggaaggtc     540

tttgagagct ggatgcacca ttggctcctg tttgaaatga gcaggcactc cttggagcaa     600

aagcccactg acgctccacc gaaagagtca ctggaactgg aggacccgtc ttctgggctg     660

ggtgtgacca agcaggatct gggcccagtc cccatgtga                            699


<210> 3
<211> 215
<212> PRT
<213> Mus <mouse, genus>

<220> 
<221> SOURCE
<222> 1..215
<223> /mol_type="protein"
      /organism="Mus <mouse, genus>"

<400> 3
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                   15    
Leu Gly Asn Arg Pro Arg Glu Pro Glu Arg Cys Ser Arg Gly Ala Leu 
            20                   25                  30        
Tyr Thr Gly Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala 
        35                   40                  45            
Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu 
    50                   55                  60                
Thr Ile Thr Ser Gln Asn Leu Gln Leu Glu Ser Leu Arg Met Lys Leu 
65                   70                  75                  80
Pro Lys Ser Ala Lys Pro Val Ser Gln Met Arg Met Ala Thr Pro Leu 
                85                   90                  95    
Leu Met Arg Pro Met Ser Met Asp Asn Met Leu Leu Gly Pro Val Lys 
            100                  105                110        
Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His Leu 
        115                  120                125            
Leu Thr Arg Ser Gly Pro Leu Glu Tyr Pro Gln Leu Lys Gly Thr Phe 
    130                  135                140                
Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asp Gly Val Asn Trp 
145                  150                155                  160
Lys Ile Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met Ser 
                165                  170                175    
Lys Asn Ser Leu Glu Glu Lys Lys Pro Thr Glu Ala Pro Pro Lys Glu 
            180                  185                190        
Pro Leu Asp Met Glu Asp Leu Ser Ser Gly Leu Gly Val Thr Arg Gln 
        195                  200                205            
Glu Leu Gly Gln Val Thr Leu 
    210                  215

<210> 4
<211> 648
<212> DNA
<213> Mus <mouse, genus>

<220> 
<221> source
<222> 1..648
<223> /mol_type="DNA"
      /organism="Mus <mouse, genus>"

<400> 4
atggatgacc aacgcgacct catctctaac catgaacagt tgcccatact gggcaaccgc      60

cctagagagc cagaaaggtg cagccgtgga gctctgtaca ccggtgtctc tgtcctggtg     120

gctctgctct tggctgggca ggccaccact gcttacttcc tgtaccagca acagggccgc     180

ctagacaagc tgaccatcac ctcccagaac ctgcaactgg agagccttcg catgaagctt     240

ccgaaatctg ccaaacctgt gagccagatg cggatggcta ctcccttgct gatgcgtcca     300

atgtccatgg ataacatgct ccttgggcct gtgaagaacg ttaccaagta cggcaacatg     360

acccaggacc atgtgatgca tctgctcacg aggtctggac ccctggagta cccgcagctg     420

aaggggacct tcccagagaa tctgaagcat cttaagaact ccatggatgg cgtgaactgg     480

aagatcttcg agagctggat gaagcagtgg ctcttgtttg agatgagcaa gaactccctg     540

gaggagaaga agcccaccga ggctccacct aaagagccac tggacatgga agacctatct     600

tctggcctgg gagtgaccag gcaggaactg ggtcaagtca ccctgtga                  648


<210> 5
<211> 296
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..296
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 5
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                   15    
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                   25                  30        
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                   40                  45            
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                   55                  60                
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                   70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                   90                  95    
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                  105                110        
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                  120                125            
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                  135                140                
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                  150                155                  160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                  170                175    
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                  185                190        
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                  200                205            
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                  215                220                
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                  230                235                  240
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                  250                255    
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
            260                  265                270        
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        275                  280                285            
Gln Asp Leu Gly Pro Val Pro Met 
    290                  295    

<210> 6
<211> 891
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..891
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 6
atgcacagga ggagaagcag gagctgtcgg gaagatcaga agccagtcat ggatgaccag      60

cgcgacctta tctccaacaa tgagcaactg cccatgctgg gccggcgccc tggggccccg     120

gagagcaagt gcagccgcgg agccctgtac acaggctttt ccatcctggt gactctgctc     180

ctcgctggcc aggccaccac cgcctacttc ctgtaccagc agcagggccg gctggacaaa     240

ctgacagtca cctcccagaa cctgcagctg gagaacctgc gcatgaagct tcccaagcct     300

cccaagcctg tgagcaagat gcgcatggcc accccgctgc tgatgcaggc gctgcccatg     360

ggagccctgc cccaggggcc catgcagaat gccaccaagt atggcaacat gacagaggac     420

catgtgatgc acctgctcca gaatgctgac cccctgaagg tgtacccgcc actgaagggg     480

agcttcccgg agaacctgag acaccttaag aacaccatgg agaccataga ctggaaggtc     540

tttgagagct ggatgcacca ttggctcctg tttgaaatga gcaggcactc cttggagcaa     600

aagcccactg acgctccacc gaaagtactg accaagtgcc aggaagaggt cagccacatc     660

cctgctgtcc acccgggttc attcaggccc aagtgcgacg agaacggcaa ctatctgcca     720

ctccagtgct atgggagcat cggctactgc tggtgtgtct tccccaacgg cacggaggtc     780

cccaacacca gaagccgcgg gcaccataac tgcagtgagt cactggaact ggaggacccg     840

tcttctgggc tgggtgtgac caagcaggat ctgggcccag tccccatgtg a              891


<210> 7
<211> 279
<212> PRT
<213> Mus <mouse, genus>

<220> 
<221> SOURCE
<222> 1..279
<223> /mol_type="protein"
      /organism="Mus <mouse, genus>"

<400> 7
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                   15    
Leu Gly Asn Arg Pro Arg Glu Pro Glu Arg Cys Ser Arg Gly Ala Leu 
            20                   25                  30        
Tyr Thr Gly Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala 
        35                   40                  45            
Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu 
    50                   55                  60                
Thr Ile Thr Ser Gln Asn Leu Gln Leu Glu Ser Leu Arg Met Lys Leu 
65                   70                  75                  80
Pro Lys Ser Ala Lys Pro Val Ser Gln Met Arg Met Ala Thr Pro Leu 
                85                   90                  95    
Leu Met Arg Pro Met Ser Met Asp Asn Met Leu Leu Gly Pro Val Lys 
            100                  105                110        
Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His Leu 
        115                  120                125            
Leu Thr Arg Ser Gly Pro Leu Glu Tyr Pro Gln Leu Lys Gly Thr Phe 
    130                  135                140                
Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asp Gly Val Asn Trp 
145                  150                155                  160
Lys Ile Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met Ser 
                165                  170                175    
Lys Asn Ser Leu Glu Glu Lys Lys Pro Thr Glu Ala Pro Pro Lys Val 
            180                  185                190        
Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val Tyr Pro 
        195                  200                205            
Gly Ala Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro Leu 
    210                  215                220                
Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Phe Pro Asn Gly 
225                  230                235                  240
Thr Glu Val Pro His Thr Lys Ser Arg Gly Arg His Asn Cys Ser Glu 
                245                  250                255    
Pro Leu Asp Met Glu Asp Leu Ser Ser Gly Leu Gly Val Thr Arg Gln 
            260                  265                270        
Glu Leu Gly Gln Val Thr Leu 
        275                

<210> 8
<211> 840
<212> DNA
<213> Mus <mouse, genus>

<220> 
<221> source
<222> 1..840
<223> /mol_type="DNA"
      /organism="Mus <mouse, genus>"

<400> 8
atggatgacc aacgcgacct catctctaac catgaacagt tgcccatact gggcaaccgc      60

cctagagagc cagaaaggtg cagccgtgga gctctgtaca ccggtgtctc tgtcctggtg     120

gctctgctct tggctgggca ggccaccact gcttacttcc tgtaccagca acagggccgc     180

ctagacaagc tgaccatcac ctcccagaac ctgcaactgg agagccttcg catgaagctt     240

ccgaaatctg ccaaacctgt gagccagatg cggatggcta ctcccttgct gatgcgtcca     300

atgtccatgg ataacatgct ccttgggcct gtgaagaacg ttaccaagta cggcaacatg     360

acccaggacc atgtgatgca tctgctcacg aggtctggac ccctggagta cccgcagctg     420

aaggggacct tcccagagaa tctgaagcat cttaagaact ccatggatgg cgtgaactgg     480

aagatcttcg agagctggat gaagcagtgg ctcttgtttg agatgagcaa gaactccctg     540

gaggagaaga agcccaccga ggctccacct aaagtactga ccaagtgcca ggaagaagtc     600

agccacatcc ctgccgtcta cccgggtgcg ttccgtccca agtgcgacga gaacggtaac     660

tatttgccac tccagtgcca cgggagcact ggctactgct ggtgtgtgtt ccccaacggc     720

actgaggttc ctcacaccaa gagccgcggg cgccataact gcagtgagcc actggacatg     780

gaagacctat cttctggcct gggagtgacc aggcaggaac tgggtcaagt caccctgtga     840


<210> 9
<211> 160
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..160
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 9
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                   15    
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                   25                  30        
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                   40                  45            
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                   55                  60                
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                   70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                   90                  95    
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                  105                110        
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                  120                125            
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                  135                140                
Leu Leu Gln Ser His Trp Asn Trp Arg Thr Arg Leu Leu Gly Trp Val 
145                  150                155                  160

<210> 10
<211> 483
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..483
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 10
atgcacagga ggagaagcag gagctgtcgg gaagatcaga agccagtcat ggatgaccag      60

cgcgacctta tctccaacaa tgagcaactg cccatgctgg gccggcgccc tggggccccg     120

gagagcaagt gcagccgcgg agccctgtac acaggctttt ccatcctggt gactctgctc     180

ctcgctggcc aggccaccac cgcctacttc ctgtaccagc agcagggccg gctggacaaa     240

ctgacagtca cctcccagaa cctgcagctg gagaacctgc gcatgaagct tcccaagcct     300

cccaagcctg tgagcaagat gcgcatggcc accccgctgc tgatgcaggc gctgcccatg     360

ggagccctgc cccaggggcc catgcagaat gccaccaagt atggcaacat gacagaggac     420

catgtgatgc acctgctcca gagtcactgg aactggagga cccgtcttct gggctgggtg     480

tga                                                                   483


<210> 11
<211> 1985
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..1985
<223> /mol_type="protein"
      /note="Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide"
      /organism="Artificial Sequence"

<400> 11
Met Ala Pro Ile Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Leu Gly 
1               5                   10                   15    
Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly 
            20                   25                  30        
Glu Val Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Cys 
        35                   40                  45            
Val Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Ser Lys Thr 
    50                   55                  60                
Leu Ala Gly Pro Lys Gly Pro Ile Thr Gln Met Tyr Thr Asn Val Asp 
65                   70                  75                  80
Gln Asp Leu Val Gly Trp Gln Ala Pro Pro Gly Ala Arg Ser Leu Thr 
                85                   90                  95    
Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
            100                  105                110        
Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu 
        115                  120                125            
Ser Pro Arg Pro Val Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu 
    130                  135                140                
Leu Cys Pro Ser Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys 
145                  150                155                  160
Thr Arg Gly Val Ala Lys Ala Val Asp Phe Val Pro Val Glu Ser Met 
                165                  170                175    
Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro 
            180                  185                190        
Ala Val Pro Gln Ser Phe Gln Val Ala His Leu His Ala Pro Thr Gly 
        195                  200                205            
Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr 
    210                  215                220                
Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly 
225                  230                235                  240
Ala Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly 
                245                  250                255    
Val Arg Thr Ile Thr Thr Gly Ala Pro Val Thr Tyr Ser Thr Tyr Gly 
            260                  265                270        
Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile 
        275                  280                285            
Ile Cys Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile Leu Gly Ile 
    290                  295                300                
Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val 
305                  310                315                  320
Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn 
                325                  330                335    
Ile Glu Glu Val Ala Leu Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly 
            340                  345                350        
Lys Ala Ile Pro Ile Glu Ala Ile Arg Gly Gly Arg His Leu Ile Phe 
        355                  360                365            
Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Gly 
    370                  375                380                
Leu Gly Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val 
385                  390                395                  400
Ile Pro Thr Ile Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met 
                405                  410                415    
Thr Gly Tyr Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys 
            420                  425                430        
Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu 
        435                  440                445            
Thr Thr Thr Val Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly 
    450                  455                460                
Arg Thr Gly Arg Gly Arg Arg Gly Ile Tyr Arg Phe Val Thr Pro Gly 
465                  470                475                  480
Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr 
                485                  490                495    
Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Ser Val 
            500                  505                510        
Arg Leu Arg Ala Tyr Leu Asn Thr Pro Gly Leu Pro Val Cys Gln Asp 
        515                  520                525            
His Leu Glu Phe Trp Glu Ser Val Phe Thr Gly Leu Thr His Ile Asp 
    530                  535                540                
Ala His Phe Leu Ser Gln Thr Lys Gln Ala Gly Asp Asn Phe Pro Tyr 
545                  550                555                  560
Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro 
                565                  570                575    
Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr 
            580                  585                590        
Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn 
        595                  600                605            
Glu Val Thr Leu Thr His Pro Ile Thr Lys Tyr Ile Met Ala Cys Met 
    610                  615                620                
Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly 
625                  630                635                  640
Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Thr Thr Gly Ser Val Val 
                645                  650                655    
Ile Val Gly Arg Ile Ile Leu Ser Gly Arg Pro Ala Ile Val Pro Asp 
            660                  665                670        
Arg Glu Phe Leu Tyr Gln Glu Phe Asp Glu Met Glu Glu Cys Ala Ser 
        675                  680                685            
His Leu Pro Tyr Ile Glu Gln Gly Met Gln Leu Ala Glu Gln Phe Lys 
    690                  695                700                
Gln Lys Ala Leu Gly Leu Leu Gln Thr Ala Thr Lys Gln Ala Glu Ala 
705                  710                715                  720
Ala Ala Pro Val Val Glu Ser Lys Trp Arg Ala Leu Glu Thr Phe Trp 
                725                  730                735    
Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu Ala Gly 
            740                  745                750        
Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met Ala Phe 
        755                  760                765            
Thr Ala Ser Ile Thr Ser Pro Leu Thr Thr Gln Ser Thr Leu Leu Phe 
    770                  775                780                
Asn Ile Leu Gly Gly Trp Val Ala Ala Gln Leu Ala Pro Pro Ser Ala 
785                  790                795                  800
Ala Ser Ala Phe Val Gly Ala Gly Ile Ala Gly Ala Ala Val Gly Ser 
                805                  810                815    
Ile Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly Tyr Gly Ala 
            820                  825                830        
Gly Val Ala Gly Ala Leu Val Ala Phe Lys Val Met Ser Gly Glu Met 
        835                  840                845            
Pro Ser Thr Glu Asp Leu Val Asn Leu Leu Pro Ala Ile Leu Ser Pro 
    850                  855                860                
Gly Ala Leu Val Val Gly Val Val Cys Ala Ala Ile Leu Arg Arg His 
865                  870                875                  880
Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg Leu Ile Ala 
                885                  890                895    
Phe Ala Ser Arg Gly Asn His Val Ser Pro Thr His Tyr Val Pro Glu 
            900                  905                910        
Ser Asp Ala Ala Ala Arg Val Thr Gln Ile Leu Ser Ser Leu Thr Ile 
        915                  920                925            
Thr Gln Leu Leu Lys Arg Leu His Gln Trp Ile Asn Glu Asp Cys Ser 
    930                  935                940                
Thr Pro Cys Ser Gly Ser Trp Leu Arg Asp Val Trp Asp Trp Ile Cys 
945                  950                955                  960
Thr Val Leu Thr Asp Phe Lys Thr Trp Leu Gln Ser Lys Leu Leu Pro 
                965                  970                975    
Gln Leu Pro Gly Val Pro Phe Phe Ser Cys Gln Arg Gly Tyr Lys Gly 
            980                  985                990        
Val Trp Arg Gly Asp Gly Ile Met Gln Thr Thr Cys Pro Cys Gly Ala 
        995                  1000                1005            
Gln Ile Thr Gly His Val Lys Asn Gly Ser Met Arg Ile Val Gly Pro 
    1010                1015                1020                
Lys Thr Cys Ser Asn Thr Trp His Gly Thr Phe Pro Ile Asn Ala Tyr 
1025                1030                1035                1040
Thr Thr Gly Pro Cys Thr Pro Ser Pro Ala Pro Asn Tyr Ser Arg Ala 
                1045                1050                1055    
Leu Trp Arg Val Ala Ala Glu Glu Tyr Val Glu Val Thr Arg Val Gly 
            1060                1065                1070        
Asp Phe His Tyr Val Thr Gly Met Thr Thr Asp Asn Val Lys Cys Pro 
        1075                1080                1085            
Cys Gln Val Pro Ala Pro Glu Phe Phe Thr Glu Val Asp Gly Val Arg 
    1090                1095                1100                
Leu His Arg Tyr Ala Pro Ala Cys Arg Pro Leu Leu Arg Glu Glu Val 
1105                1110                1115                1120
Thr Phe Gln Val Gly Leu Asn Gln Tyr Leu Val Gly Ser Gln Leu Pro 
                1125                1130                1135    
Cys Glu Pro Glu Pro Asp Val Ala Val Leu Thr Ser Met Leu Thr Asp 
            1140                1145                1150        
Pro Ser His Ile Thr Ala Glu Thr Ala Lys Arg Arg Leu Ala Arg Gly 
        1155                1160                1165            
Ser Pro Pro Ser Leu Ala Ser Ser Ser Ala Ser Gln Leu Ser Ala Pro 
    1170                1175                1180                
Ser Leu Lys Ala Thr Cys Thr Thr His His Val Ser Pro Asp Ala Asp 
1185                1190                1195                1200
Leu Ile Glu Ala Asn Leu Leu Trp Arg Gln Glu Met Gly Gly Asn Ile 
                1205                1210                1215    
Thr Arg Val Glu Ser Glu Asn Lys Val Val Val Leu Asp Ser Phe Asp 
            1220                1225                1230        
Pro Leu Arg Ala Glu Glu Asp Glu Arg Glu Val Ser Val Pro Ala Glu 
        1235                1240                1245            
Ile Leu Arg Lys Ser Lys Lys Phe Pro Ala Ala Met Pro Ile Trp Ala 
    1250                1255                1260                
Arg Pro Asp Tyr Asn Pro Pro Leu Leu Glu Ser Trp Lys Asp Pro Asp 
1265                1270                1275                1280
Tyr Val Pro Pro Val Val His Gly Cys Pro Leu Pro Pro Ile Lys Ala 
                1285                1290                1295    
Pro Pro Ile Pro Pro Pro Arg Arg Lys Arg Thr Val Val Leu Thr Glu 
            1300                1305                1310        
Ser Ser Val Ser Ser Ala Leu Ala Glu Leu Ala Thr Lys Thr Phe Gly 
        1315                1320                1325            
Ser Ser Glu Ser Ser Ala Val Asp Ser Gly Thr Ala Thr Ala Leu Pro 
    1330                1335                1340                
Asp Gln Ala Ser Asp Asp Gly Asp Lys Gly Ser Asp Val Glu Ser Tyr 
1345                1350                1355                1360
Ser Ser Met Pro Pro Leu Glu Gly Glu Pro Gly Asp Pro Asp Leu Ser 
                1365                1370                1375    
Asp Gly Ser Trp Ser Thr Val Ser Glu Glu Ala Ser Glu Asp Val Val 
            1380                1385                1390        
Cys Cys Ser Met Ser Tyr Thr Trp Thr Gly Ala Leu Ile Thr Pro Cys 
        1395                1400                1405            
Ala Ala Glu Glu Ser Lys Leu Pro Ile Asn Ala Leu Ser Asn Ser Leu 
    1410                1415                1420                
Leu Arg His His Asn Met Val Tyr Ala Thr Thr Ser Arg Ser Ala Gly 
1425                1430                1435                1440
Leu Arg Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp 
                1445                1450                1455    
His Tyr Arg Asp Val Leu Lys Glu Met Lys Ala Lys Ala Ser Thr Val 
            1460                1465                1470        
Lys Ala Lys Leu Leu Ser Val Glu Glu Ala Cys Lys Leu Thr Pro Pro 
        1475                1480                1485            
His Ser Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val Arg Asn 
    1490                1495                1500                
Leu Ser Ser Lys Ala Val Asn His Ile His Ser Val Trp Lys Asp Leu 
1505                1510                1515                1520
Leu Glu Asp Thr Val Thr Pro Ile Asp Thr Thr Ile Met Ala Lys Asn 
                1525                1530                1535    
Glu Val Phe Cys Val Gln Pro Glu Lys Gly Gly Arg Lys Pro Ala Arg 
            1540                1545                1550        
Leu Ile Val Phe Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala 
        1555                1560                1565            
Leu Tyr Asp Val Val Ser Thr Leu Pro Gln Val Val Met Gly Ser Ser 
    1570                1575                1580                
Tyr Gly Phe Gln Tyr Ser Pro Gly Gln Arg Val Glu Phe Leu Val Asn 
1585                1590                1595                1600
Thr Trp Lys Ser Lys Lys Asn Pro Met Gly Phe Ser Tyr Asp Thr Arg 
                1605                1610                1615    
Cys Phe Asp Ser Thr Val Thr Glu Asn Asp Ile Arg Val Glu Glu Ser 
            1620                1625                1630        
Ile Tyr Gln Cys Cys Asp Leu Ala Pro Glu Ala Arg Gln Ala Ile Lys 
        1635                1640                1645            
Ser Leu Thr Glu Arg Leu Tyr Ile Gly Gly Pro Leu Thr Asn Ser Lys 
    1650                1655                1660                
Gly Gln Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr 
1665                1670                1675                1680
Thr Ser Cys Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Ser Ala Ala 
                1685                1690                1695    
Cys Arg Ala Ala Lys Leu Gln Asp Cys Thr Met Leu Val Asn Ala Ala 
            1700                1705                1710        
Gly Leu Val Val Ile Cys Glu Ser Ala Gly Thr Gln Glu Asp Ala Ala 
        1715                1720                1725            
Ser Leu Arg Val Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro 
    1730                1735                1740                
Gly Asp Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys 
1745                1750                1755                1760
Ser Ser Asn Val Ser Val Ala His Asp Ala Ser Gly Lys Arg Val Tyr 
                1765                1770                1775    
Tyr Leu Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu 
            1780                1785                1790        
Thr Ala Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met 
        1795                1800                1805            
Tyr Ala Pro Thr Leu Trp Ala Arg Met Ile Leu Met Thr His Phe Phe 
    1810                1815                1820                
Ser Ile Leu Leu Ala Gln Glu Gln Leu Glu Lys Ala Leu Asp Cys Gln 
1825                1830                1835                1840
Ile Tyr Gly Ala Cys Tyr Ser Ile Glu Pro Leu Asp Leu Pro Gln Ile 
                1845                1850                1855    
Ile Glu Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser 
            1860                1865                1870        
Pro Gly Glu Ile Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly Val 
        1875                1880                1885            
Pro Pro Leu Arg Val Trp Arg His Arg Ala Arg Ser Val Arg Ala Arg 
    1890                1895                1900                
Leu Leu Ser Gln Gly Gly Arg Ala Ala Thr Cys Gly Lys Tyr Leu Phe 
1905                1910                1915                1920
Asn Trp Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Ile Pro Ala Ala 
                1925                1930                1935    
Ser Gln Leu Asp Leu Ser Gly Trp Phe Val Ala Gly Tyr Ser Gly Gly 
            1940                1945                1950        
Asp Ile Tyr His Ser Leu Ser Arg Ala Arg Pro Arg Trp Phe Met Leu 
        1955                1960                1965            
Cys Leu Leu Leu Leu Ser Val Gly Val Gly Ile Tyr Leu Leu Pro Asn 
    1970                1975                1980                
Arg 
1985

