                         SEQUENCE LISTING

<110>  Novelogics Biotechnology, Inc.
 
<120>  Methods and Devices for Removal of Immunosuppressive Ligands

<130>  NBI-002PCT

<150>  61/852493
<151>  2013-03-15

<150>  61/490373
<151>  2014-02-15

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  2
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Met Val Leu Ser Gln Asp Glu Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Ala Lys 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
                85                  90                  95      


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg 
        115                 120                 125             


Gly Ser Arg His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Gly Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe 
305                 310                 315                 320 


Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  3
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Pro Pro Met Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn 
1               5                   10                  15      


Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr 
            20                  25                  30          


Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln 
        35                  40                  45              


Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val 
    50                  55                  60                  


Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met 
65                  70                  75                  80  


Glu His Ser Gly Asn His Ser Thr His Pro Val Pro Ser 
                85                  90              


<210>  4
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn 
1               5                   10                  15      


Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr 
            20                  25                  30          


Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln 
        35                  40                  45              


Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val 
    50                  55                  60                  


Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met 
65                  70                  75                  80  


Glu His Ser Gly Asn His Gly Thr His Pro Val Pro Ser 
                85                  90              


<210>  5
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  5
cactgcttga gccgctgaga gggtggcgac gtcggggcca tggggctggg cccggtcttc       60

ctgcttctgg ctggcatctt cccttttgca cctccgggag ctgctgctga gccccacagt      120

cttcgttata acctcacggt gctgtcctgg gatggatctg tgcagtcagg gtttctcact      180

gaggtacatc tggatggtca gcccttcctg cgctgtgaca ggcagaaatg cagggcaaag      240

ccccagggac agtgggcaga agatgtcctg ggaaataaga catgggacag agagaccaga      300

gacttgacag ggaacggaaa ggacctcagg atgaccctgg ctcatatcaa ggaccagaaa      360

gaaggcttgc attccctcca ggagattagg gtctgtgaga tccatgaaga caacagcacc      420

aggagctccc agcatttcta ctacgatggg gagctcttcc tctcccaaaa cctggagact      480

aaggaatgga caatgcccca gtcctccaga gctcagacct tggccatgaa cgtcaggaat      540

ttcttgaagg aagatgccat gaagaccaag acacactatc acgctatgca tgcagactgc      600

ctgcaggaac tacggcgata tctaaaatcc ggcgtagtcc tgaggagaac agtgcccccc      660

atggtgaatg tcacccgcag cgaggcctca gagggcaaca ttaccgtgac atgcagggct      720

tctggcttct atccctggaa tatcacactg agctggcgtc aggatggggt atctttgagc      780

cacgacaccc agcagtgggg ggatgtcctg cctgatggga atggaaccta ccagacctgg      840

gtggccacca ggatttgcca aggagaggag cagaggttca cctgctacat ggaacacagc      900

gggaatcaca gcactcaccc tgtgccctct gggaaagtgc tggtgcttca gagtcattgg      960

cagacattcc atgtttctgc tgttgctgct gctgctattt ttgttattat tattttctat     1020

gtccgttgtt gtaagaagaa aacatcagct gcagagggtc cagagctcgt gagcctgcag     1080

gtcctggatc aacacccagt tgggacgagt gaccacaggg atgccacaca gctcggattt     1140

cagcctctga tgtcagatct tgggtccact ggctccactg agggcgccta gactctacag     1200

ccaggcagct gggattcaat tccctgcctg gatctcacga gcactttccc tcttggtgcc     1260

tcagtttcct gacctatgaa acagagaaaa taaaagcact tatttattgt tgttggaggc     1320

tgcaaaatgt tagtagatat gaggcgtttg cagctgtacc atatt                     1365


<210>  6
<211>  2380
<212>  DNA
<213>  Homo sapiens

<400>  6
gggccatggg gctgggccgg gtcctgctgt ttctggccgt cgccttccct tttgcacccc       60

cggcagccgc cgctgagccc cacagtcttc gttacaacct catggtgctg tcccaggatg      120

aatctgtgca gtcagggttt ctcgctgagg gacatctgga tggtcagccc ttcctgcgct      180

atgacaggca gaaacgcagg gcaaagcccc agggacagtg ggcagaagat gtcctgggag      240

ctaagacctg ggacacagag accgaggact tgacagagaa tgggcaagac ctcaggagga      300

ccctgactca tatcaaggac cagaaaggag gcttgcattc cctccaggag attagggtct      360

gtgagatcca tgaagacagc agcaccaggg gctcccggca tttctactac gatggggagc      420

tcttcctctc ccaaaacctg gagactcaag aatcgacagt gccccagtcc tccagagctc      480

agaccttggc tatgaacgtc acaaatttct ggaaggaaga tgccatgaag accaagacac      540

actatcgcgc tatgcaggca gactgcctgc agaaactaca gcgatatctg aaatccgggg      600

tggccatcag gagaacagtg ccccccatgg tgaatgtcac ctgcagcgag gtctcagagg      660

gcaacatcac cgtgacatgc agggcttcca gcttctatcc ccggaatatc acactgacct      720

ggcgtcagga tggggtatct ttgagccaca acacccagca gtggggggat gtcctgcctg      780

atgggaatgg aacctaccag acctgggtgg ccaccaggat tcgccaagga gaggagcaga      840

ggttcacctg ctacatggaa cacagcggga atcacggcac tcaccctgtg ccctctggga      900

aggtgctggt gcttcagagt caacggacag actttccata tgtttctgct gctatgccat      960

gttttgttat tattattatt ctctgtgtcc cttgttgcaa gaagaaaaca tcagcggcag     1020

agggtccaga gcttgtgagc ctgcaggtcc tggatcaaca cccagttggg acaggagacc     1080

acagggatgc agcacagctg ggatttcagc ctctgatgtc agctactggg tccactggtt     1140

ccactgaggg cgcctagact ctacagccag gcggccagga ttcaactccc tgcctggatc     1200

tcaccagcac tttccctctg tttcctgacc tatgaaacag aaaataacat cacttattta     1260

ttgttgttgg atgctgcaaa gtgttagtag gtatgaggtg tttgctgctc tgccacgtag     1320

agagccagca aagggatcat gaccaactca acattccatt ggaggctata tgatcaaaca     1380

gcaaattgtt tatcatgaat gcaggatgtg ggcaaactca cgactgctcc tgccaacaga     1440

aggtttgctg agggcattca ctccatggtg ctcattggag ttatctactg ggtcatctag     1500

agcctattgt ttgaggaatg cagtcttaca agcctactct ggacccagca gctgactcct     1560

tcttccaccc ctcttcttgc tatctcctat accaataaat acgaagggct gtggaagatc     1620

agagcccttg ttcacgagaa gcaagaagcc ccctgacccc ttgttccaaa tatactcttt     1680

tgtctttctc tttattccca cgttcgccct ttgttcagtc caatacaggg ttgtggggcc     1740

cttaacagtg ccatattaat tggtatcatt atttctgttg tttttgtttt tgtttttgtt     1800

tttgtttttg agacagagtc tcactcgtca cccaggctgc agttcactgg tgtgatctca     1860

gctcactgca acctctgcct cccaggttca agcacttctc gtacctcaga ctcccgatag     1920

ctgggattac agacaggcac caccacaccc agctaatttt tgtatttttt gtagagacgg     1980

ggtttcgcca agttgaccag cccagtttca aactcctgac ctcaggtgat ctgcctgcct     2040

tggcatccca aagtgctggg attacaagaa tgagccaccg tgcctggcct attttattat     2100

attgtaatat attttattat attagccacc atgcctgtcc tattttctta tgttttaata     2160

tattttaata tattacatgt gcagtaatta gattatcatg ggtgaacttt atgagtgagt     2220

atcttggtga tgactcctcc tgaccagccc aggaccagct ttcttgtcac cttgaggtcc     2280

cctcgccccg tcacaccgtt atcgattact ctgtgtctac tattatgtgt gcataattta     2340

taccgtaaat gtttactctt taaataaaaa aaaaaaaaaa                           2380


<210>  7
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  8
<211>  1606
<212>  DNA
<213>  Homo sapiens

<400>  8
actaagtatc tccactttca attctagatc aggaactgag gacatatcta aattttctag       60

ttttatagaa ggcttttatc cacaagaatc aagatcttcc ctctctgagc aggaatcctt      120

tgtgcattga agactttaga ttcctctctg cggtagacgt gcacttataa gtatttgatg      180

gggtggattc gtggtcggag gtctcgacac agctgggaga tgagtgaatt tcataattat      240

aacttggatc tgaagaagag tgatttttca acacgatggc aaaagcaaag atgtccagta      300

gtcaaaagca aatgtagaga aaatgcatct ccattttttt tctgctgctt catcgctgta      360

gccatgggaa tccgtttcat tattatggta acaatatgga gtgctgtatt cctaaactca      420

ttattcaacc aagaagttca aattcccttg accgaaagtt actgtggccc atgtcctaaa      480

aactggatat gttacaaaaa taactgctac caattttttg atgagagtaa aaactggtat      540

gagagccagg cttcttgtat gtctcaaaat gccagccttc tgaaagtata cagcaaagag      600

gaccaggatt tacttaaact ggtgaagtca tatcattgga tgggactagt acacattcca      660

acaaatggat cttggcagtg ggaagatggc tccattctct cacccaacct actaacaata      720

attgaaatgc agaagggaga ctgtgcactc tatgcctcga gctttaaagg ctatatagaa      780

aactgttcaa ctccaaatac gtacatctgc atgcaaagga ctgtgtaaag atgatcaacc      840

atctcaataa aagccaggaa cagagaagag attacaccag cggtaacact gccaactgag      900

actaaaggaa acaaacaaaa acaggacaaa atgaccaaag actgtcagat ttcttagact      960

ccacaggacc aaaccataga acaatttcac tgcaaacatg catgattctc caagacaaaa     1020

gaagagagat cctaaaggca attcagatat ccccaaggct gcctctccca ccacaagccc     1080

agagtggatg ggctggggga ggggtgctgt tttaatttct aaaggtagga ccaacaccca     1140

ggggatcagt gaaggaagag aaggccagca gatcactgag agtgcaaccc caccctccac     1200

aggaaattgc ctcatgggca gggccacagc agagagacac agcatgggca gtgccttccc     1260

tgcctgtggg ggtcatgctg ccacttttaa tgggtcctcc acccaacggg gtcagggagg     1320

tggtgctgcc ccagtgggcc atgattatct taaaggcatt attctccagc cttaagtaag     1380

atcttaggac gtttcctttg ctatgatttg tacttgcttg agtcccatga ctgtttctct     1440

tcctctcttt cttccttttg gaatagtaat atccatccta tgtttgtccc actattgtat     1500

tttggaagca cataacttgt ttggtttcac aggttcacag ttaagaagga attttgcctc     1560

tgaataaata gaatcttgag tctcatgcaa aaaaaaaaaa aaaaaa                    1606


<210>  9
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ser Lys Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr 
1               5                   10                  15      


Ser Gln Glu Gln Gln Lys Gln Arg Leu Ala Leu Thr Thr Ser Gln Pro 
            20                  25                  30          


Gly Glu Asn Gly Ile Ile Arg Gly Arg Tyr Pro Ile Glu Lys Leu Lys 
        35                  40                  45              


Ile Ser Pro Met Phe Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile 
    50                  55                  60                  


Arg Phe Thr Leu Asn Thr Leu Met Trp Leu Ala Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu 
                85                  90                  95      


Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn 
            100                 105                 110         


Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala 
        115                 120                 125             


Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu 
    130                 135                 140                 


Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
145                 150                 155                 160 


Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser 
                165                 170                 175     


Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys 
            180                 185                 190         


Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn 
        195                 200                 205             


Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
    210                 215                 


<210>  10
<211>  215
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Ser Lys Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr 
1               5                   10                  15      


Ser Gln Glu His Gln Lys Gln Arg Ser Ala Leu Pro Thr Ser Arg Pro 
            20                  25                  30          


Gly Glu Asn Gly Ile Ile Arg Arg Arg Ser Ser Ile Glu Glu Leu Lys 
        35                  40                  45              


Ile Ser Pro Leu Phe Val Val Arg Val Leu Val Ala Ala Met Thr Ile 
    50                  55                  60                  


Arg Phe Thr Val Ile Thr Leu Thr Trp Leu Ala Val Phe Ile Thr Leu 
65                  70                  75                  80  


Leu Cys Asn Lys Glu Val Ser Val Ser Ser Arg Glu Gly Tyr Cys Gly 
                85                  90                  95      


Pro Cys Pro Asn Asp Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe 
            100                 105                 110         


Phe Asn Glu Asn Lys Ala Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser 
        115                 120                 125             


Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe 
    130                 135                 140                 


Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ser Pro 
145                 150                 155                 160 


Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Pro Asn 
                165                 170                 175     


Glu Leu Thr Leu Val Lys Thr Pro Ser Gly Thr Cys Ala Val Tyr Gly 
            180                 185                 190         


Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ser Asn Pro Asn Thr Tyr 
        195                 200                 205             


Ile Cys Met Lys Arg Ala Val 
    210                 215 


<210>  11
<211>  216
<212>  PRT
<213>  Macaca mulatta

<400>  11

Met Gly Trp Ile Arg Gly Arg Arg Pro Arg His Asn Leu Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Lys Leu Gly Leu Ala Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Cys Gln Lys Gln Arg Cys Pro Val Ile Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Leu Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asn Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Ile Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  12
<211>  216
<212>  PRT
<213>  Macaca fascicularis

<400>  12

Met Gly Trp Ile Arg Gly Arg Arg Pro Arg His Asn Leu Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Lys Leu Gly Leu Ala Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Cys Gln Lys Gln Arg Cys Pro Val Ile Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Leu Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asn Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Ile Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  13
<211>  216
<212>  PRT
<213>  Callithrix jacchus

<400>  13

Met Gly Trp Ile Arg Gly Arg Arg Pro Arg His Ser Leu Ala Met Ser 
1               5                   10                  15      


Glu Phe Arg Asn Tyr Asn Leu Glu Leu Ala Lys Gly Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Ile Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Phe Thr Pro Leu Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Val Met Val Thr Ile Trp Thr Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Val Pro Leu Ile Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asn Glu Asn Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Ala Glu Gln Asp 
    130                 135                 140                 


Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Tyr Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Thr Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Val Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Thr Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Lys Thr Val 
    210                 215     


<210>  14
<211>  216
<212>  PRT
<213>  Pan troglodytes

<400>  14

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asn Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  15
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Ala Ala Ala Ser Pro Ala Phe Leu Leu Cys Leu Pro Leu Leu 
1               5                   10                  15      


His Leu Leu Ser Gly Trp Ser Arg Ala Gly Trp Val Asp Thr His Cys 
            20                  25                  30          


Leu Cys Tyr Asp Phe Ile Ile Thr Pro Lys Ser Arg Pro Glu Pro Gln 
        35                  40                  45              


Trp Cys Glu Val Gln Gly Leu Val Asp Glu Arg Pro Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Val Asn His Lys Ala Lys Ala Phe Ala Ser Leu Gly Lys Lys 
65                  70                  75                  80  


Val Asn Val Thr Lys Thr Trp Glu Glu Gln Thr Glu Thr Leu Arg Asp 
                85                  90                  95      


Val Val Asp Phe Leu Lys Gly Gln Leu Leu Asp Ile Gln Val Glu Asn 
            100                 105                 110         


Leu Ile Pro Ile Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


His Glu Ala His Gly His Gly Arg Gly Ser Trp Gln Phe Leu Phe Asn 
    130                 135                 140                 


Gly Gln Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg Lys Trp Thr Ala 
145                 150                 155                 160 


Leu His Pro Gly Ala Lys Lys Met Thr Glu Lys Trp Glu Lys Asn Arg 
                165                 170                 175     


Asp Val Thr Met Phe Phe Gln Lys Ile Ser Leu Gly Asp Cys Lys Met 
            180                 185                 190         


Trp Leu Glu Glu Phe Leu Met Tyr Trp Glu Gln Met Leu Asp Pro Thr 
        195                 200                 205             


Lys Pro Pro Ser Leu Ala Pro Gly Thr Thr Gln Pro Lys Ala Met Ala 
    210                 215                 220                 


Thr Thr Leu Ser Pro Trp Ser Leu Leu Ile Ile Phe Leu Cys Phe Ile 
225                 230                 235                 240 


Leu Ala Gly Arg 
                


<210>  16
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ala Ala Ala Ala Thr Lys Ile Leu Leu Cys Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Gly Trp Ser Arg Ala Gly Arg Ala Asp Pro His Ser 
            20                  25                  30          


Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg 
        35                  40                  45              


Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys 
65                  70                  75                  80  


Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu 
                85                  90                  95      


Val Val Asp Ile Leu Thr Glu Gln Leu Arg Asp Ile Gln Leu Glu Asn 
            100                 105                 110         


Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Phe Asp 
    130                 135                 140                 


Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr 
145                 150                 155                 160 


Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys 
                165                 170                 175     


Val Val Ala Met Ser Phe His Tyr Phe Ser Met Gly Asp Cys Ile Gly 
            180                 185                 190         


Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser 
        195                 200                 205             


Ala Gly Ala Pro Leu Ala Met Ser Ser Gly Thr Thr Gln Leu Arg Ala 
    210                 215                 220                 


Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Ile Leu Pro Cys 
225                 230                 235                 240 


Phe Ile Leu Pro Gly Ile 
                245     


<210>  17
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ala Ala Ala Ser Pro Ala Ile Leu Pro Arg Leu Ala Ile Leu 
1               5                   10                  15      


Pro Tyr Leu Leu Phe Asp Trp Ser Gly Thr Gly Arg Ala Asp Ala His 
            20                  25                  30          


Ser Leu Trp Tyr Asn Phe Thr Ile Ile His Leu Pro Arg His Gly Gln 
        35                  40                  45              


Gln Trp Cys Glu Val Gln Ser Gln Val Asp Gln Lys Asn Phe Leu Ser 
    50                  55                  60                  


Tyr Asp Cys Gly Ser Asp Lys Val Leu Ser Met Gly His Leu Glu Glu 
65                  70                  75                  80  


Gln Leu Tyr Ala Thr Asp Ala Trp Gly Lys Gln Leu Glu Met Leu Arg 
                85                  90                  95      


Glu Val Gly Gln Arg Leu Arg Leu Glu Leu Ala Asp Thr Glu Leu Glu 
            100                 105                 110         


Asp Phe Thr Pro Ser Gly Pro Leu Thr Leu Gln Val Arg Met Ser Cys 
        115                 120                 125             


Glu Cys Glu Ala Asp Gly Tyr Ile Arg Gly Ser Trp Gln Phe Ser Phe 
    130                 135                 140                 


Asp Gly Arg Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg Lys Trp Thr 
145                 150                 155                 160 


Val Val His Ala Gly Ala Arg Arg Met Lys Glu Lys Trp Glu Lys Asp 
                165                 170                 175     


Ser Gly Leu Thr Thr Phe Phe Lys Met Val Ser Met Arg Asp Cys Lys 
            180                 185                 190         


Ser Trp Leu Arg Asp Phe Leu Met His Arg Lys Lys Arg Leu Glu Pro 
        195                 200                 205             


Thr Ala Pro Pro Thr Met Ala Pro Gly Leu Ala Gln Pro Lys Ala Ile 
    210                 215                 220                 


Ala Thr Thr Leu Ser Pro Trp Ser Phe Leu Ile Ile Leu Cys Phe Ile 
225                 230                 235                 240 


Leu Pro Gly Ile 
                


<210>  18
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Arg Arg Ile Ser Leu Thr Ser Ser Pro Val Arg Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ile Ala Leu Glu Ile Met Tyr Asn Ser Asp Asn 
            20                  25                  30          


Asn Met Val Lys Pro Leu Gly Leu Leu Gly Lys Lys Val Tyr Ala Thr 
        35                  40                  45              


Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu Gly Glu Val Gly Arg Asp 
    50                  55                  60                  


Leu Arg Met Leu Leu Cys Asp Ile Lys Pro Gln Ile Lys Thr Ser Asp 
65                  70                  75                  80  


Pro Ser Thr Leu Gln Val Glu Met Phe Cys Gln Arg Glu Ala Glu Arg 
                85                  90                  95      


Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr Asn Gly Glu Lys Ser Leu 
            100                 105                 110         


Leu Phe Asp Ala Met Asn Met Thr Trp Thr Val Ile Asn His Glu Ala 
        115                 120                 125             


Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp Arg Gly Leu Glu Lys Tyr 
    130                 135                 140                 


Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp His Trp Leu Arg Glu Phe 
145                 150                 155                 160 


Leu Gly His Trp Glu Ala Met Pro Glu Pro Thr Val Ser Pro Val Asn 
                165                 170                 175     


Ala Ser Asp Ile His Trp Ser Ser Ser Ser Leu Pro Asp Arg Trp Ile 
            180                 185                 190         


Ile Leu Gly Ala Phe Ile Leu Leu Val Leu Met Gly Ile Val Leu Ile 
        195                 200                 205             


Cys Val Trp Trp Gln Asn Gly Glu Trp Gln Ala Gly Leu Trp Pro Leu 
    210                 215                 220                 


Arg Thr Ser 
225         


<210>  19
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Ala Ala Ser Pro Ala Phe Leu Leu Arg Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Ser Trp Cys Arg Thr Gly Leu Ala Asp Pro His Ser 
            20                  25                  30          


Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg 
        35                  40                  45              


Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Gly Ser Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys 
65                  70                  75                  80  


Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu 
                85                  90                  95      


Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu Asn 
            100                 105                 110         


Tyr Ile Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


Gln Lys Ala Glu Gly His Gly Ser Gly Ser Trp Gln Leu Ser Phe Asp 
    130                 135                 140                 


Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Asn Arg Met Trp Thr Thr 
145                 150                 155                 160 


Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys 
                165                 170                 175     


Asp Met Thr Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Thr Gly 
            180                 185                 190         


Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser 
        195                 200                 205             


Ala Gly Ala Pro Pro Thr Met Ser Ser Gly Thr Ala Gln Pro Arg Ala 
    210                 215                 220                 


Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Met Cys Leu Leu 
225                 230                 235                 240 


Ile Cys Ser Arg His Ser Leu Thr Gln Ser His Gly His His Pro Gln 
                245                 250                 255     


Ser Leu Gln Pro Pro Pro His Pro Pro Leu Leu His Pro Thr Trp Leu 
            260                 265                 270         


Leu Arg Arg Val Leu Trp Ser Asp Ser Tyr Gln Ile Ala Lys Arg Pro 
        275                 280                 285             


Leu Ser Gly Gly His Val Thr Arg Val Thr Leu Pro Ile Ile Gly Asp 
    290                 295                 300                 


Asp Ser His Ser Leu Pro Cys Pro Leu Ala Leu Tyr Thr Ile Asn Asn 
305                 310                 315                 320 


Gly Ala Ala Arg Tyr Ser Glu Pro Leu Gln Val Ser Ile Ser 
                325                 330                 


<210>  20
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ala Ala Ala Ile Pro Ala Leu Leu Leu Cys Leu Pro Leu Leu 
1               5                   10                  15      


Phe Leu Leu Phe Gly Trp Ser Arg Ala Arg Arg Asp Asp Pro His Ser 
            20                  25                  30          


Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg 
        35                  40                  45              


Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys 
65                  70                  75                  80  


Leu Asn Val Thr Met Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu 
                85                  90                  95      


Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu Asn 
            100                 105                 110         


Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Ile Asp 
    130                 135                 140                 


Gly Gln Thr Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr 
145                 150                 155                 160 


Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys 
                165                 170                 175     


Asp Val Ala Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Ile Gly 
            180                 185                 190         


Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser 
        195                 200                 205             


Ala Gly Ala Pro Leu Ala Met Ser Ser Gly Thr Thr Gln Leu Arg Ala 
    210                 215                 220                 


Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Ile Leu Pro Cys 
225                 230                 235                 240 


Phe Ile Leu Pro Gly Ile 
                245     


<210>  21
<211>  230
<212>  PRT
<213>  Human cytomegalovirus

<400>  21

Met Glu Arg Arg Arg Gly Thr Val Pro Leu Gly Trp Val Phe Phe Val 
1               5                   10                  15      


Leu Cys Leu Ser Ala Ser Ser Ser Cys Ala Val Asp Leu Gly Ser Lys 
            20                  25                  30          


Ser Ser Asn Ser Thr Cys Arg Leu Asn Val Thr Glu Leu Ala Ser Ile 
        35                  40                  45              


His Pro Gly Glu Thr Trp Thr Leu His Gly Met Cys Ile Ser Ile Cys 
    50                  55                  60                  


Tyr Tyr Glu Asn Val Thr Glu Asp Glu Ile Ile Gly Val Ala Phe Thr 
65                  70                  75                  80  


Trp Gln His Asn Glu Ser Val Val Asp Leu Trp Leu Tyr Gln Asn Asp 
                85                  90                  95      


Thr Val Ile Arg Asn Phe Ser Asp Ile Thr Thr Asn Ile Leu Gln Asp 
            100                 105                 110         


Gly Leu Lys Met Arg Thr Val Pro Val Thr Lys Leu Tyr Thr Ser Arg 
        115                 120                 125             


Met Val Thr Asn Leu Thr Val Gly Arg Tyr Asp Cys Leu Arg Cys Glu 
    130                 135                 140                 


Asn Gly Thr Thr Lys Ile Ile Glu Arg Leu Tyr Val Arg Leu Gly Ser 
145                 150                 155                 160 


Leu Tyr Pro Arg Pro Pro Gly Ser Gly Leu Ala Lys His Pro Ser Val 
                165                 170                 175     


Ser Ala Asp Glu Glu Leu Ser Ala Thr Leu Ala Arg Asp Ile Val Leu 
            180                 185                 190         


Val Ser Ala Ile Thr Leu Phe Phe Phe Leu Leu Ala Leu Arg Ile Pro 
        195                 200                 205             


Gln Arg Leu Cys Gln Arg Leu Arg Ile Arg Leu Pro His Arg Tyr Gln 
    210                 215                 220                 


Arg Leu Arg Thr Glu Asp 
225                 230 


<210>  22
<211>  306
<212>  PRT
<213>  Human cytomegalovirus

<400>  22

Met Arg Ile Glu Trp Val Trp Trp Leu Phe Gly Tyr Phe Val Ser Ser 
1               5                   10                  15      


Val Gly Ser Glu Arg Ser Leu Ser Tyr Arg Tyr His Leu Glu Ser Asn 
            20                  25                  30          


Ser Ser Thr Asn Val Val Cys Asn Gly Asn Ile Ser Val Phe Val Asn 
        35                  40                  45              


Gly Thr Leu Gly Val Arg Tyr Asn Ile Thr Val Gly Ile Ser Ser Ser 
    50                  55                  60                  


Leu Leu Ile Gly His Leu Thr Ile Gln Val Leu Glu Ser Trp Phe Thr 
65                  70                  75                  80  


Pro Trp Val Gln Asn Lys Ser Tyr Asn Lys Gln Pro Leu Gly Asp Thr 
                85                  90                  95      


Glu Thr Leu Tyr Asn Ile Asp Ser Glu Asn Ile His Arg Val Ser Gln 
            100                 105                 110         


Tyr Phe His Thr Arg Trp Ile Lys Ser Leu Gln Glu Asn His Thr Cys 
        115                 120                 125             


Asp Leu Thr Asn Ser Thr Pro Thr Tyr Thr Tyr Gln Val Asn Val Asn 
    130                 135                 140                 


Asn Thr Asn Tyr Leu Thr Leu Thr Ser Ser Gly Trp Gln Asp Arg Leu 
145                 150                 155                 160 


Asn Tyr Thr Val Ile Asn Ser Thr His Phe Asn Leu Thr Glu Ser Asn 
                165                 170                 175     


Ile Thr Ser Ile Gln Lys Tyr Leu Asn Thr Thr Cys Ile Glu Arg Leu 
            180                 185                 190         


Arg Asn Tyr Thr Leu Glu Ser Val Tyr Thr Thr Thr Val Pro Gln Asn 
        195                 200                 205             


Ile Thr Thr Ser Gln His Ala Thr Thr Thr Met His Thr Ile Pro Pro 
    210                 215                 220                 


Asn Thr Ile Thr Ile Gln Asn Thr Thr Gln Ser His Thr Val Gln Thr 
225                 230                 235                 240 


Pro Ser Phe Asn Asp Thr His Asn Val Thr Lys His Thr Leu Asn Ile 
                245                 250                 255     


Ser Tyr Val Leu Ser Gln Lys Thr Asn Asn Thr Thr Ser Pro Trp Ile 
            260                 265                 270         


Tyr Ala Ile Pro Met Gly Ala Thr Ala Thr Ile Gly Ala Gly Leu Tyr 
        275                 280                 285             


Ile Gly Lys His Phe Thr Pro Val Lys Phe Val Tyr Glu Val Trp Arg 
    290                 295                 300                 


Gly Gln 
305     


<210>  23
<211>  430
<212>  PRT
<213>  Human herpesvirus 7

<400>  23

Met Trp Thr Ile Leu Leu Phe Cys Val Pro Val Ile Tyr Gly Glu Leu 
1               5                   10                  15      


Tyr Pro Asp Phe Cys Pro Leu Ala Val Val Asp Phe Asp Val Asn Ala 
            20                  25                  30          


Thr Val Asp Asp Leu Leu Leu Phe Asp Ile Ser Leu Ser Lys Gln Cys 
        35                  40                  45              


Ser Asp Asp Lys Ile Arg His Ser Ala Val Ala Ala Met Thr Asp Asn 
    50                  55                  60                  


Ala Phe Phe Phe Gly Asn Ser Glu Thr Gln Ile Glu Thr Asp Phe Gly 
65                  70                  75                  80  


Lys Tyr Leu Ala Phe Asn Cys Tyr Gln Val Phe Ser Thr Leu Asn His 
                85                  90                  95      


Phe Leu Phe Lys Asn Phe Lys Lys Thr Lys Gly Leu Met Lys Arg Tyr 
            100                 105                 110         


Asp Lys Leu Cys Leu Asp Val Glu Ser Tyr Ile His Ile Gln Ile Ile 
        115                 120                 125             


Cys Ser Pro Phe Lys Ser Phe Ile Arg Leu Arg Arg Met Asn Glu Thr 
    130                 135                 140                 


Gly Ile Ser Pro Arg Ile Leu Glu Thr Thr Phe Tyr Leu Gln Asn Lys 
145                 150                 155                 160 


Arg Asn Ser Thr Trp Val Ala Ile Lys Asn Tyr Leu Gly Glu Asp Asp 
                165                 170                 175     


Pro Phe Thr Tyr Arg Ile Trp His Thr Leu Thr His Ala Lys Asn Phe 
            180                 185                 190         


Leu Ile Asn Ser Cys Glu Asn Asp Phe Asn Gln Leu Phe Phe Trp Gln 
        195                 200                 205             


Arg Lys Tyr Leu Ser Leu Ala Lys Thr Phe Glu Ala Thr Phe Lys Gln 
    210                 215                 220                 


Gly Phe Asn Pro Met Ile Glu Gln Arg Asn Glu Gln Arg Tyr Arg Thr 
225                 230                 235                 240 


Asn Asn Ile Asp Cys Ser Phe Ser Lys Phe Arg Gln Asn Gly Val Lys 
                245                 250                 255     


Val Ala Val Cys Lys Tyr Thr Gly Trp Gly Val Ser Gly Phe Gly Ser 
            260                 265                 270         


Leu Glu Val Leu Gln Lys Ile Lys Ser Pro Phe Gly Glu Glu Trp Lys 
        275                 280                 285             


Arg Val Gly Phe Asn Ser Thr Gly Ala Phe Thr Pro Leu Tyr Gly Ser 
    290                 295                 300                 


Asp Val Leu Trp Gly Leu Ile Phe Leu Arg Val Glu Met Thr Thr Tyr 
305                 310                 315                 320 


Val Cys Thr Cys Thr Asn Lys Asn Thr Gly Thr Gln Ile Gln Val Thr 
                325                 330                 335     


Leu Pro Asp Val Asp Leu Asp Leu Leu Asp Ser Glu Lys Thr Ser Ser 
            340                 345                 350         


Asn Val Phe Val Asp Met Leu Cys Tyr Thr Leu Ile Ala Ile Leu Phe 
        355                 360                 365             


Leu Ala Phe Val Thr Ala Val Val Leu Leu Gly Val Ser Cys Leu Asp 
    370                 375                 380                 


Gly Val Gln Lys Val Leu Thr Trp Pro Leu Gln His Ile Gln Lys Glu 
385                 390                 395                 400 


Pro Val Ser Glu Lys Ile Ile Asn Leu Thr Asn Leu Met Phe Gly Gln 
                405                 410                 415     


Glu Pro Leu Pro Lys Lys Glu Ser Leu Lys Gln Gln Cys Leu 
            420                 425                 430 


<210>  24
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  24

Arg Ser Glu Ala Ser Glu Gly 
1               5           


<210>  25
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Gln Asp Gly Val 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Pro Asp Gly Asn 
1               5   


<210>  27
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Gly Glu Glu Gln Arg 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Gly Glu Glu Gln Arg 
1               5       


<210>  29
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  29

Cys Ser Glu Val Ser Glu Gly 
1               5           


<210>  30
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Gln Asp Gly Val 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  31

Leu Pro Asp Gly Asn 
1               5   


<210>  32
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  32

Arg Gln Gly Glu Glu Gln Arg 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg or Cys

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Glu or Lys

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Ala or Val

<400>  33

Xaa Ser Xaa Xaa Ser Glu Gly 
1               5           


<210>  34
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Val or Leu

<400>  34

Arg Gln Asp Gly Xaa 
1               5   


<210>  35
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg or Cys

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Gln, Arg, or Glu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is Arg, Ser, or Lys

<400>  35

Xaa Xaa Gly Glu Glu Gln Xaa 
1               5           


<210>  36
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  36

Leu Pro Asp Gly Asn 
1               5   


<210>  37
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region of antibody 1F5

<400>  37

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105                 110         


<210>  38
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region of antibody 1F5

<400>  38

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Val His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Gly Gly Asn Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  39
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region of antibody 8C7

<400>  39

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Gln Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu Tyr Trp Phe Met Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  40
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region of antibody 8C7

<400>  40

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Ser Ser Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L1 of antibody 1F5

<400>  41

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L2 of antibody 1F5

<400>  42

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L3 of antibody 1F5

<400>  43

Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H1 of antibody 1F5

<400>  44

Asp Tyr Ser Val His 
1               5   


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H1 of antibody 1F5

<400>  45

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H1 of antibody 1F5

<400>  46

Gly Tyr Thr Phe Thr Asp Tyr Ser Val His 
1               5                   10  


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H2 of antibody 1F5

<400>  47

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H2 of antibody 1F5

<400>  48

Asn Thr Glu Thr Gly 
1               5   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H2 of antibody 1F5

<400>  49

Trp Ile Asn Thr Glu Thr Gly Glu Pro 
1               5                   


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H3 of antibody 1F5

<400>  50

Ala Gly Gly Asn Ala Phe Ala Tyr 
1               5               


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L1 of antibody 8C7

<400>  51

Arg Ser Ser Lys Ser Leu Leu Gln Ser Asn Gly Asn Thr Phe Leu Tyr 
1               5                   10                  15      


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L2 of antibody 8C7

<400>  52

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L3 of antibody 8C7

<400>  53

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H1 of antibody 8C7

<400>  54

Asn Tyr Gly Met Asn 
1               5   


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H1 of antibody 8C7

<400>  55

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H1 of antibody 8C7

<400>  56

Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H2 of antibody 8C7

<400>  57

Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H2 of antibody 8C7

<400>  58

Asn Thr Asn Thr Gly 
1               5   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H2 of antibody 8C7

<400>  59

Trp Ile Asn Thr Asn Thr Gly Glu Pro 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H3 of antibody 8C7

<400>  60

Ser Gly Gly Ser Ser Pro Phe Ala Tyr 
1               5                   


<210>  61
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  61

Asn Gly Thr Tyr Gln Thr 
1               5       


