                         SEQUENCE LISTING

<110>  Cancer Research Technology Limited
 
<120>  Diagnostic and Prognostic Biomarkers for Prostate Cancer and 
       Other Disorders

<130>  EAH/BP6968366

<150>  GB 1304612.3
<151>  2013-03-14

<160>  19    

<170>  PatentIn version 3.3

<210>  1
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Forward primer

<400>  1
acgcaccctg tctgactaca acat                                            24


<210>  2
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Reverse primer

<400>  2
agggatgcct tccttgtctt ggat                                            24


<210>  3
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Forward primer

<400>  3
aagaagatct tggacagcgt gggt                                            24


<210>  4
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Reverse primer

<400>  4
taccctgggc aatgacgtct tcaa                                            24


<210>  5
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Forward primer

<400>  5
gaaggtgaag gtcggagtc                                                  19


<210>  6
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Reverse primer

<400>  6
aagatggtga tgggatttc                                                  19


<210>  7
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Forward primer

<400>  7
tagttggtgg agctgttggt ggat                                            24


<210>  8
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Reverse primer

<400>  8
tttcctccac gagtgatgcc ttct                                            24


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Forward primer

<400>  9
gcctagagga tgtttcatgg g                                               21


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Reverse primer

<400>  10
tgtcgtactt ctccctctcc                                                 20


<210>  11
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Forward primer

<400>  11
tgactctgag cagcagtggt caat                                            24


<210>  12
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Reverse primer

<400>  12
agccttgaga gttcctttgg caga                                            24


<210>  13
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Glu Asn Glu Ala Ser Leu Pro Asn Thr Ser Leu Gln Gly Lys 
1               5                   10                  15      


Lys Met Ala Tyr Gln Lys Val His Ala Asp Gln Arg Ala Pro Gly His 
            20                  25                  30          


Ser Gln Tyr Leu Asp Asn Asp Asp Leu Gln Ala Thr Ala Leu Asp Leu 
        35                  40                  45              


Glu Trp Asp Met Glu Lys Glu Leu Glu Glu Ser Gly Phe Asp Gln Phe 
    50                  55                  60                  


Gln Leu Asp Gly Ala Glu Asn Gln Asn Leu Gly His Ser Glu Thr Ile 
65                  70                  75                  80  


Asp Leu Asn Leu Asp Ser Ile Gln Pro Ala Thr Ser Pro Lys Gly Arg 
                85                  90                  95      


Phe Gln Arg Leu Gln Glu Glu Ser Asp Tyr Ile Thr His Tyr Thr Arg 
            100                 105                 110         


Ser Ala Pro Lys Ser Asn Arg Cys Asn Phe Cys His Val Leu Lys Ile 
        115                 120                 125             


Leu Cys Thr Ala Thr Ile Leu Phe Ile Phe Gly Ile Leu Ile Gly Tyr 
    130                 135                 140                 


Tyr Val His Thr Asn Cys Pro Ser Asp Ala Pro Ser Ser Gly Thr Val 
145                 150                 155                 160 


Asp Pro Gln Leu Tyr Gln Glu Ile Leu Lys Thr Ile Gln Ala Glu Asp 
                165                 170                 175     


Ile Lys Lys Ser Phe Arg Asn Leu Val Gln Leu Tyr Lys Asn Glu Asp 
            180                 185                 190         


Asp Met Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser Leu Gly 
        195                 200                 205             


Leu Glu Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp Leu Pro 
    210                 215                 220                 


Gly Pro Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln Cys Phe 
225                 230                 235                 240 


His Pro Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp Ser Ser 
                245                 250                 255     


Gln Asp Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly Thr Leu 
            260                 265                 270         


Lys Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys 
        275                 280                 285             


Arg Ile Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu Leu Lys 
    290                 295                 300                 


Leu Gly Lys Leu Pro Leu Leu Tyr Lys Leu Ser Ser Leu Glu Lys Ala 
305                 310                 315                 320 


Gly Phe Gly Gly Val Leu Leu Tyr Ile Asp Pro Cys Asp Leu Pro Lys 
                325                 330                 335     


Thr Val Asn Pro Ser His Asp Thr Phe Met Val Ser Leu Asn Pro Gly 
            340                 345                 350         


Gly Asp Pro Ser Thr Pro Gly Tyr Pro Ser Val Asp Glu Ser Phe Arg 
        355                 360                 365             


Gln Ser Arg Ser Asn Leu Thr Ser Leu Leu Val Gln Pro Ile Ser Ala 
    370                 375                 380                 


Pro Leu Val Ala Lys Leu Ile Ser Ser Pro Lys Ala Arg Thr Lys Asn 
385                 390                 395                 400 


Glu Ala Cys Ser Ser Leu Glu Leu Pro Asn Asn Glu Ile Arg Val Val 
                405                 410                 415     


Ser Met Gln Val Gln Thr Val Thr Lys Leu Lys Thr Val Thr Asn Val 
            420                 425                 430         


Val Gly Phe Val Met Gly Leu Thr Ser Pro Asp Arg Tyr Ile Ile Val 
        435                 440                 445             


Gly Ser His His His Thr Ala His Ser Tyr Asn Gly Gln Glu Trp Ala 
    450                 455                 460                 


Ser Ser Thr Ala Ile Ile Thr Ala Phe Ile Arg Ala Leu Met Ser Lys 
465                 470                 475                 480 


Val Lys Arg Gly Trp Arg Pro Asp Arg Thr Ile Val Phe Cys Ser Trp 
                485                 490                 495     


Gly Gly Thr Ala Phe Gly Asn Ile Gly Ser Tyr Glu Trp Gly Glu Asp 
            500                 505                 510         


Phe Lys Lys Val Leu Gln Lys Asn Val Val Ala Tyr Ile Ser Leu His 
        515                 520                 525             


Ser Pro Ile Arg Gly Asn Ser Ser Leu Tyr Pro Val Ala Ser Pro Ser 
    530                 535                 540                 


Leu Gln Gln Leu Val Val Glu Lys Asn Asn Phe Asn Cys Thr Arg Arg 
545                 550                 555                 560 


Ala Gln Cys Pro Glu Thr Asn Ile Ser Ser Ile Gln Ile Gln Gly Asp 
                565                 570                 575     


Ala Asp Tyr Phe Ile Asn His Leu Gly Val Pro Ile Val Gln Phe Ala 
            580                 585                 590         


Tyr Glu Asp Ile Lys Thr Leu Glu Gly Pro Ser Phe Leu Ser Glu Ala 
        595                 600                 605             


Arg Phe Ser Thr Arg Ala Thr Lys Ile Glu Glu Met Asp Pro Ser Phe 
    610                 615                 620                 


Asn Leu His Glu Thr Ile Thr Lys Leu Ser Gly Glu Val Ile Leu Gln 
625                 630                 635                 640 


Ile Ala Asn Glu Pro Val Leu Pro Phe Asn Ala Leu Asp Ile Ala Leu 
                645                 650                 655     


Glu Val Gln Asn Asn Leu Lys Gly Asp Gln Pro Asn Thr His Gln Leu 
            660                 665                 670         


Leu Ala Met Ala Leu Arg Leu Arg Glu Ser Ala Glu Leu Phe Gln Ser 
        675                 680                 685             


Asp Glu Met Arg Pro Ala Asn Asp Pro Lys Glu Arg Ala Pro Ile Arg 
    690                 695                 700                 


Ile Arg Met Leu Asn Asp Ile Leu Gln Asp Met Glu Lys Ser Phe Leu 
705                 710                 715                 720 


Val Lys Gln Ala Pro Pro Gly Phe Tyr Arg Asn Ile Leu Tyr His Leu 
                725                 730                 735     


Asp Glu Lys Thr Ser Arg Phe Ser Ile Leu Ile Glu Ala Trp Glu His 
            740                 745                 750         


Cys Lys Pro Leu Ala Ser Asn Glu Thr Leu Gln Glu Ala Leu Ser Glu 
        755                 760                 765             


Val Leu Asn Ser Ile Asn Ser Ala Gln Val Tyr Phe Lys Ala Gly Leu 
    770                 775                 780                 


Asp Val Phe Lys Ser Val Leu Asp Gly Lys Asn 
785                 790                 795 


<210>  14
<211>  1715
<212>  DNA
<213>  Homo sapiens

<400>  14
gggtcagtag aaagtcagaa ggtcacaaag cttgcagggt aagtgacaca acttgaaact     60

gcttggccct ctttaaaaag aaataataaa atgggagaga atgaagcaag tttacctaac    120

acgtctttgc aaggtaaaaa gatggcctat cagaaggtcc atgcagatca aagagctcca    180

ggacactcac agtacttaga caatgatgac cttcaagcca ctgcccttga cttagagtgg    240

gacatggaga aggaactaga ggagtctggt tttgaccaat tccagctaga cagtgctgag    300

aatcagaacc tagggcattc agagactata gacctcaatc ttgattccat tcaaccagca    360

acttcaccca aaggaaggtt ccagagactt caagaagaat ctgactacat tacccattat    420

acacgatctg caccaaagag caatcgctgc aacttttgcc acgtcttaaa aatgctttgc    480

acagccacca ttttatttat ttttgggatt ttgataggtt attatgtaca tacaaattgc    540

ccttcagatg ctccatcttc aggaacagtt gatcctcagt tatatcaaga gattctcaag    600

acaatccagg cagaagatat taagaagtct ttcagaaatt tggtacaact atataaaaat    660

gaagatgaca tggaaatttc aaagaagatt aagactcagt ggacctcttt gggcctagaa    720

gatgtacagt ttgtaaatta ctctgtgctg cttgatctgc caggcccttc tcccagcact    780

gtgactctga gcagcagtgg tcaatgcttt catcctaatg gccagccttg cagtgaagaa    840

gccagaaaag atagcagcca agacctgctc tattcatatg cagcctattc tgccaaagga    900

actctcaagg ctgaagtcat cgatgtgagt tatggaatgg cagatgattt aaaaaggatt    960

aggaaaataa aaaacgtaac aaatcagatc gcactcctga aattaggaaa attgccactg   1020

ctttataagg ttggtccagt gaatgttatt cagtggtttg gtcaatattt tgccttgttt   1080

tgttggaatt atatgctttt gtgagtgtgg agtgtgtgtg tgcatatagg tgtgtgagag   1140

agagaagggg agaggaagaa agagaggcag agagtgtcac agaaagatgg cttttccaca   1200

ttagaacatt ttaatttaag atatttaaga acaatatatt tatgccctta tttctttaga   1260

gagaaaatac cttaagtcag gtaacactga gtttgtggga ccttaataaa attggcatac   1320

tcttcataat ggtacctatc tggaatagta aaaatagaga accaccctgt gttcatctta   1380

tgacatatgt gaaacttcta atctattatc aaatggacta attatcatgt tctctatgtt   1440

agacaagtat ctagatgatt tacacccttt agtgattatt ttgtcaacta tacaactaca   1500

gttactaact gtgatcagga ttttaattaa aatataattg ctaagagtag cagaattttg   1560

atttatttta tttgaatgga agtttattaa cactcatcca cagatacact tatgtaatta   1620

agtttctgat gatgaaccag cacaatagac agccactact gctcattctc gcttcatttc   1680

ctttttctat ttaaaaaaaa aaaaaaaaaa aaaaa                              1715


<210>  15
<211>  3174
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val Phe Glu Ser Val Val Val Asp Val Leu Asn Arg Phe Leu Gly 
1               5                   10                  15      


Asp Tyr Val Val Asp Leu Asp Thr Ser Gln Leu Ser Leu Gly Ile Trp 
            20                  25                  30          


Lys Gly Ala Val Ala Leu Lys Asn Leu Gln Ile Lys Glu Asn Ala Leu 
        35                  40                  45              


Ser Gln Leu Asp Val Pro Phe Lys Val Lys Val Gly His Ile Gly Asn 
    50                  55                  60                  


Leu Lys Leu Ile Ile Pro Trp Lys Asn Leu Tyr Thr Gln Pro Val Glu 
65                  70                  75                  80  


Ala Val Leu Glu Glu Ile Tyr Leu Leu Ile Val Pro Ser Ser Arg Ile 
                85                  90                  95      


Lys Tyr Asp Pro Leu Lys Glu Glu Lys Gln Leu Met Glu Ala Lys Gln 
            100                 105                 110         


Gln Glu Leu Lys Arg Ile Glu Glu Ala Lys Gln Lys Val Val Asp Gln 
        115                 120                 125             


Glu Gln His Leu Pro Glu Lys Gln Asp Thr Phe Ala Glu Lys Leu Val 
    130                 135                 140                 


Thr Gln Ile Ile Lys Asn Leu Gln Val Lys Ile Ser Ser Ile His Ile 
145                 150                 155                 160 


Arg Tyr Glu Asp Asp Ile Thr Asn Arg Asp Lys Pro Leu Ser Phe Gly 
                165                 170                 175     


Ile Ser Leu Gln Asn Leu Ser Met Gln Thr Thr Asp Gln Tyr Trp Val 
            180                 185                 190         


Pro Cys Leu His Asp Glu Thr Glu Lys Leu Val Arg Lys Leu Ile Arg 
        195                 200                 205             


Leu Asp Asn Leu Phe Ala Tyr Trp Asn Val Lys Ser Gln Met Phe Tyr 
    210                 215                 220                 


Leu Ser Asp Tyr Asp Asn Ser Leu Asp Asp Leu Lys Asn Gly Ile Val 
225                 230                 235                 240 


Asn Glu Asn Ile Val Pro Glu Gly Tyr Asp Phe Val Phe Arg Pro Ile 
                245                 250                 255     


Ser Ala Asn Ala Lys Leu Val Met Asn Arg Arg Ser Asp Phe Asp Phe 
            260                 265                 270         


Ser Ala Pro Lys Ile Asn Leu Glu Ile Glu Leu His Asn Ile Ala Ile 
        275                 280                 285             


Glu Phe Asn Lys Pro Gln Tyr Phe Ser Ile Met Glu Leu Leu Glu Ser 
    290                 295                 300                 


Val Asp Met Met Ala Gln Asn Leu Pro Tyr Arg Lys Phe Lys Pro Asp 
305                 310                 315                 320 


Val Pro Leu His His His Ala Arg Glu Trp Trp Ala Tyr Ala Ile His 
                325                 330                 335     


Gly Val Leu Glu Val Asn Val Cys Pro Arg Leu Trp Met Trp Ser Trp 
            340                 345                 350         


Lys His Ile Arg Lys His Arg Gln Lys Val Lys Gln Tyr Lys Glu Leu 
        355                 360                 365             


Tyr Lys Lys Lys Leu Thr Ser Lys Lys Pro Pro Gly Glu Leu Leu Val 
    370                 375                 380                 


Ser Leu Glu Glu Leu Glu Lys Thr Leu Asp Val Phe Asn Ile Thr Ile 
385                 390                 395                 400 


Ala Arg Gln Thr Ala Glu Val Glu Val Lys Lys Ala Gly Tyr Lys Ile 
                405                 410                 415     


Tyr Lys Glu Gly Val Lys Asp Pro Glu Asp Asn Lys Gly Trp Phe Ser 
            420                 425                 430         


Trp Leu Trp Ser Trp Ser Glu Gln Asn Thr Asn Glu Gln Gln Pro Asp 
        435                 440                 445             


Val Gln Pro Glu Thr Leu Glu Glu Met Leu Thr Pro Glu Glu Lys Ala 
    450                 455                 460                 


Leu Leu Tyr Glu Ala Ile Gly Tyr Ser Glu Thr Ala Val Asp Pro Thr 
465                 470                 475                 480 


Leu Leu Lys Thr Phe Glu Ala Leu Lys Phe Phe Val His Leu Lys Ser 
                485                 490                 495     


Met Ser Ile Val Leu Arg Glu Asn His Gln Lys Pro Glu Leu Val Asp 
            500                 505                 510         


Ile Val Ile Glu Glu Phe Ser Thr Leu Ile Val Gln Arg Pro Gly Ala 
        515                 520                 525             


Gln Ala Ile Lys Phe Glu Thr Lys Ile Asp Ser Phe His Ile Thr Gly 
    530                 535                 540                 


Leu Pro Asp Asn Ser Glu Lys Pro Arg Leu Leu Ser Ser Leu Asp Asp 
545                 550                 555                 560 


Ala Met Ser Leu Phe Gln Ile Thr Phe Glu Ile Asn Pro Leu Asp Glu 
                565                 570                 575     


Thr Val Ser Gln Arg Cys Ile Ile Glu Ala Glu Pro Leu Glu Ile Ile 
            580                 585                 590         


Tyr Asp Ala Arg Thr Val Asn Ser Ile Val Glu Phe Phe Arg Pro Pro 
        595                 600                 605             


Lys Glu Val His Leu Ala Gln Leu Thr Ala Ala Thr Leu Thr Lys Leu 
    610                 615                 620                 


Glu Glu Phe Arg Ser Lys Thr Ala Thr Gly Leu Leu Tyr Ile Ile Glu 
625                 630                 635                 640 


Thr Gln Lys Val Leu Asp Leu Lys Ile Asn Leu Lys Ala Ser Tyr Ile 
                645                 650                 655     


Ile Val Pro Gln Asp Gly Ile Phe Ser Pro Thr Ser Asn Leu Leu Leu 
            660                 665                 670         


Leu Asp Leu Gly His Leu Lys Val Thr Ser Lys Ser Arg Ser Glu Leu 
        675                 680                 685             


Pro Asp Val Lys Gln Gly Glu Ala Asn Leu Lys Glu Ile Met Asp Arg 
    690                 695                 700                 


Ala Tyr Asp Ser Phe Asp Ile Gln Leu Thr Ser Val Gln Leu Leu Tyr 
705                 710                 715                 720 


Ser Arg Val Gly Asp Asn Trp Arg Glu Ala Arg Lys Leu Ser Val Ser 
                725                 730                 735     


Thr Gln His Ile Leu Val Pro Met His Phe Asn Leu Glu Leu Ser Lys 
            740                 745                 750         


Ala Met Val Phe Met Asp Val Arg Met Pro Lys Phe Lys Ile Tyr Gly 
        755                 760                 765             


Lys Leu Pro Leu Ile Ser Leu Arg Ile Ser Asp Lys Lys Leu Gln Gly 
    770                 775                 780                 


Ile Met Glu Leu Ile Glu Ser Ile Pro Lys Pro Glu Pro Val Thr Glu 
785                 790                 795                 800 


Val Ser Ala Pro Val Lys Ser Phe Gln Ile Gln Thr Ser Thr Ser Leu 
                805                 810                 815     


Gly Thr Ser Gln Ile Ser Gln Lys Ile Ile Pro Leu Leu Glu Leu Pro 
            820                 825                 830         


Ser Val Ser Glu Asp Asp Ser Glu Glu Glu Phe Phe Asp Ala Pro Cys 
        835                 840                 845             


Ser Pro Leu Glu Glu Pro Leu Gln Phe Pro Thr Gly Val Lys Ser Ile 
    850                 855                 860                 


Arg Thr Arg Lys Leu Gln Lys Gln Asp Cys Ser Val Asn Met Thr Thr 
865                 870                 875                 880 


Phe Lys Ile Arg Phe Glu Val Pro Lys Val Leu Ile Glu Phe Tyr His 
                885                 890                 895     


Leu Val Gly Asp Cys Glu Leu Ser Val Val Glu Ile Leu Val Leu Gly 
            900                 905                 910         


Leu Gly Ala Glu Ile Glu Ile Arg Thr Tyr Asp Leu Lys Ala Asn Ala 
        915                 920                 925             


Phe Leu Lys Glu Phe Cys Leu Lys Cys Pro Glu Tyr Leu Asp Glu Asn 
    930                 935                 940                 


Lys Lys Pro Val Tyr Leu Val Thr Thr Leu Asp Asn Thr Met Glu Asp 
945                 950                 955                 960 


Leu Leu Thr Leu Glu Tyr Val Lys Ala Glu Lys Asn Val Pro Asp Leu 
                965                 970                 975     


Lys Ser Thr Tyr Asn Asn Val Leu Gln Leu Ile Lys Val Asn Phe Ser 
            980                 985                 990         


Ser Leu Asp Ile His Leu His Thr  Glu Ala Leu Leu Asn  Thr Ile Asn 
        995                 1000                 1005             


Tyr Leu  His Asn Ile Leu Pro  Gln Ser Glu Glu Lys  Ser Ala Pro 
    1010                 1015                 1020             


Val Ser  Thr Thr Glu Thr Glu  Asp Lys Gly Asp Val  Ile Lys Lys 
    1025                 1030                 1035             


Leu Ala  Leu Lys Leu Ser Thr  Asn Glu Asp Ile Ile  Thr Leu Gln 
    1040                 1045                 1050             


Ile Leu  Ala Glu Leu Ser Cys  Leu Gln Ile Phe Ile  Gln Asp Gln 
    1055                 1060                 1065             


Lys Cys  Asn Ile Ser Glu Ile  Lys Ile Glu Gly Leu  Asp Ser Glu 
    1070                 1075                 1080             


Met Ile  Met Arg Pro Ser Glu  Thr Glu Ile Asn Ala  Lys Leu Arg 
    1085                 1090                 1095             


Asn Ile  Ile Val Leu Asp Ser  Asp Ile Thr Ala Ile  Tyr Lys Lys 
    1100                 1105                 1110             


Ala Val  Tyr Ile Thr Gly Lys  Glu Val Phe Ser Phe  Lys Met Val 
    1115                 1120                 1125             


Ser Tyr  Met Asp Ala Thr Ala  Gly Ser Ala Tyr Thr  Asp Met Asn 
    1130                 1135                 1140             


Val Val  Asp Ile Gln Val Asn  Leu Ile Val Gly Cys  Ile Glu Val 
    1145                 1150                 1155             


Val Phe  Val Thr Lys Phe Leu  Tyr Ser Ile Leu Ala  Phe Ile Asp 
    1160                 1165                 1170             


Asn Phe  Gln Ala Ala Lys Gln  Ala Leu Ala Glu Ala  Thr Val Gln 
    1175                 1180                 1185             


Ala Ala  Gly Met Ala Ala Thr  Gly Val Lys Glu Leu  Ala Gln Arg 
    1190                 1195                 1200             


Ser Ser  Arg Met Ala Leu Asp  Ile Asn Ile Lys Ala  Pro Val Val 
    1205                 1210                 1215             


Val Ile  Pro Gln Ser Pro Val  Ser Glu Asn Val Phe  Val Ala Asp 
    1220                 1225                 1230             


Phe Gly  Leu Ile Thr Met Thr  Asn Thr Phe His Met  Ile Thr Glu 
    1235                 1240                 1245             


Ser Gln  Ser Ser Pro Pro Pro  Val Ile Asp Leu Ile  Thr Ile Lys 
    1250                 1255                 1260             


Leu Ser  Glu Met Arg Leu Tyr  Arg Ser Arg Phe Ile  Asn Asp Ala 
    1265                 1270                 1275             


Tyr Gln  Glu Val Leu Asp Leu  Leu Leu Pro Leu Asn  Leu Glu Val 
    1280                 1285                 1290             


Val Val  Glu Arg Asn Leu Cys  Trp Glu Trp Tyr Gln  Glu Val Pro 
    1295                 1300                 1305             


Cys Phe  Asn Val Asn Ala Gln  Leu Lys Pro Met Glu  Phe Ile Leu 
    1310                 1315                 1320             


Ser Gln  Glu Asp Ile Thr Thr  Ile Phe Lys Thr Leu  His Gly Asn 
    1325                 1330                 1335             


Ile Trp  Tyr Glu Lys Asp Gly  Ser Ala Ser Pro Ala  Val Thr Lys 
    1340                 1345                 1350             


Asp Gln  Tyr Ser Ala Thr Ser  Gly Val Thr Thr Asn  Ala Ser His 
    1355                 1360                 1365             


His Ser  Gly Gly Ala Thr Val  Val Thr Ala Ala Val  Val Glu Val 
    1370                 1375                 1380             


His Ser  Arg Ala Leu Leu Val  Lys Thr Thr Leu Asn  Ile Ser Phe 
    1385                 1390                 1395             


Lys Thr  Asp Asp Leu Thr Met  Val Leu Tyr Ser Pro  Gly Pro Lys 
    1400                 1405                 1410             


Gln Ala  Ser Phe Thr Asp Val  Arg Asp Pro Ser Leu  Lys Leu Ala 
    1415                 1420                 1425             


Glu Phe  Lys Leu Glu Asn Ile  Ile Ser Thr Leu Lys  Met Tyr Thr 
    1430                 1435                 1440             


Asp Gly  Ser Thr Phe Ser Ser  Phe Ser Leu Lys Asn  Cys Ile Leu 
    1445                 1450                 1455             


Asp Asp  Lys Arg Pro His Val  Lys Lys Ala Thr Pro  Arg Met Ile 
    1460                 1465                 1470             


Gly Leu  Thr Val Gly Phe Asp  Lys Lys Asp Met Met  Asp Ile Lys 
    1475                 1480                 1485             


Tyr Arg  Lys Val Arg Asp Gly  Cys Val Thr Asp Ala  Val Phe Gln 
    1490                 1495                 1500             


Glu Met  Tyr Ile Cys Ala Ser  Val Glu Phe Leu Gln  Thr Val Ala 
    1505                 1510                 1515             


Asn Val  Phe Leu Glu Ala Tyr  Thr Thr Gly Thr Ala  Val Glu Thr 
    1520                 1525                 1530             


Ser Val  Gln Thr Trp Thr Ala  Lys Glu Glu Val Pro  Thr Gln Glu 
    1535                 1540                 1545             


Ser Val  Lys Trp Glu Ile Asn  Val Ile Ile Lys Asn  Pro Glu Ile 
    1550                 1555                 1560             


Val Phe  Val Ala Asp Met Thr  Lys Asn Asp Ala Pro  Ala Leu Val 
    1565                 1570                 1575             


Ile Thr  Thr Gln Cys Glu Ile  Cys Tyr Lys Gly Asn  Leu Glu Asn 
    1580                 1585                 1590             


Ser Thr  Met Thr Ala Ala Ile  Lys Asp Leu Gln Val  Arg Ala Cys 
    1595                 1600                 1605             


Pro Phe  Leu Pro Val Lys Arg  Lys Gly Lys Ile Thr  Thr Val Leu 
    1610                 1615                 1620             


Gln Pro  Cys Asp Leu Phe Tyr  Gln Thr Thr Gln Lys  Gly Thr Asp 
    1625                 1630                 1635             


Pro Gln  Val Ile Asp Met Ser  Val Lys Ser Leu Thr  Leu Lys Val 
    1640                 1645                 1650             


Ser Pro  Val Ile Ile Asn Thr  Met Ile Thr Ile Thr  Ser Ala Leu 
    1655                 1660                 1665             


Tyr Thr  Thr Lys Glu Thr Ile  Pro Glu Glu Thr Ala  Ser Ser Thr 
    1670                 1675                 1680             


Ala His  Leu Trp Glu Lys Lys  Asp Thr Lys Thr Leu  Lys Met Trp 
    1685                 1690                 1695             


Phe Leu  Glu Glu Ser Asn Glu  Thr Glu Lys Ile Ala  Pro Thr Thr 
    1700                 1705                 1710             


Glu Leu  Val Pro Lys Gly Glu  Met Ile Lys Met Asn  Ile Asp Ser 
    1715                 1720                 1725             


Ile Phe  Ile Val Leu Glu Ala  Gly Ile Gly His Arg  Thr Val Pro 
    1730                 1735                 1740             


Met Leu  Leu Ala Lys Ser Arg  Phe Ser Gly Glu Gly  Lys Asn Trp 
    1745                 1750                 1755             


Ser Ser  Leu Ile Asn Leu His  Cys Gln Leu Glu Leu  Glu Val His 
    1760                 1765                 1770             


Tyr Tyr  Asn Glu Met Phe Gly  Val Trp Glu Pro Leu  Leu Glu Pro 
    1775                 1780                 1785             


Leu Glu  Ile Asp Gln Thr Glu  Asp Phe Arg Pro Trp  Asn Leu Gly 
    1790                 1795                 1800             


Ile Lys  Met Lys Lys Lys Ala  Lys Met Ala Ile Val  Glu Ser Asp 
    1805                 1810                 1815             


Pro Glu  Glu Glu Asn Tyr Lys  Val Pro Glu Tyr Lys  Thr Val Ile 
    1820                 1825                 1830             


Ser Phe  His Ser Lys Asp Gln  Leu Asn Ile Thr Leu  Ser Lys Cys 
    1835                 1840                 1845             


Gly Leu  Val Met Leu Asn Asn  Leu Val Lys Ala Phe  Thr Glu Ala 
    1850                 1855                 1860             


Ala Thr  Gly Ser Ser Ala Asp  Phe Val Lys Asp Leu  Ala Pro Phe 
    1865                 1870                 1875             


Met Ile  Leu Asn Ser Leu Gly  Leu Thr Ile Ser Val  Ser Pro Ser 
    1880                 1885                 1890             


Asp Ser  Phe Ser Val Leu Asn  Ile Pro Met Ala Lys  Ser Tyr Val 
    1895                 1900                 1905             


Leu Lys  Asn Gly Glu Ser Leu  Ser Met Asp Tyr Ile  Arg Thr Lys 
    1910                 1915                 1920             


Asp Asn  Asp His Phe Asn Ala  Met Thr Ser Leu Ser  Ser Lys Leu 
    1925                 1930                 1935             


Phe Phe  Ile Leu Leu Thr Pro  Val Asn His Ser Thr  Ala Asp Lys 
    1940                 1945                 1950             


Ile Pro  Leu Thr Lys Val Gly  Arg Arg Leu Tyr Thr  Val Arg His 
    1955                 1960                 1965             


Arg Glu  Ser Gly Val Glu Arg  Ser Ile Val Cys Gln  Ile Asp Thr 
    1970                 1975                 1980             


Val Glu  Gly Ser Lys Lys Val  Thr Ile Arg Ser Pro  Val Gln Ile 
    1985                 1990                 1995             


Arg Asn  His Phe Ser Val Pro  Leu Ser Val Tyr Glu  Gly Asp Thr 
    2000                 2005                 2010             


Leu Leu  Gly Thr Ala Ser Pro  Glu Asn Glu Phe Asn  Ile Pro Leu 
    2015                 2020                 2025             


Gly Ser  Tyr Arg Ser Phe Ile  Phe Leu Lys Pro Glu  Asp Glu Asn 
    2030                 2035                 2040             


Tyr Gln  Met Cys Glu Gly Ile  Asp Phe Glu Glu Ile  Ile Lys Asn 
    2045                 2050                 2055             


Asp Gly  Ala Leu Leu Lys Lys  Lys Cys Arg Ser Lys  Asn Pro Ser 
    2060                 2065                 2070             


Lys Glu  Ser Phe Leu Ile Asn  Ile Val Pro Glu Lys  Asp Asn Leu 
    2075                 2080                 2085             


Thr Ser  Leu Ser Val Tyr Ser  Glu Asp Gly Trp Asp  Leu Pro Tyr 
    2090                 2095                 2100             


Ile Met  His Leu Trp Pro Pro  Ile Leu Leu Arg Asn  Leu Leu Pro 
    2105                 2110                 2115             


Tyr Lys  Ile Ala Tyr Tyr Ile  Glu Gly Ile Glu Asn  Ser Val Phe 
    2120                 2125                 2130             


Thr Leu  Ser Glu Gly His Ser  Ala Gln Ile Cys Thr  Ala Gln Leu 
    2135                 2140                 2145             


Gly Lys  Ala Arg Leu His Leu  Lys Leu Leu Asp Tyr  Leu Asn His 
    2150                 2155                 2160             


Asp Trp  Lys Ser Glu Tyr His  Ile Lys Pro Asn Gln  Gln Asp Ile 
    2165                 2170                 2175             


Ser Phe  Val Ser Phe Thr Cys  Val Thr Glu Met Glu  Lys Thr Asp 
    2180                 2185                 2190             


Leu Asp  Ile Ala Val His Met  Thr Tyr Asn Thr Gly  Gln Thr Val 
    2195                 2200                 2205             


Val Ala  Phe His Ser Pro Tyr  Trp Met Val Asn Lys  Thr Gly Arg 
    2210                 2215                 2220             


Met Leu  Gln Tyr Lys Ala Asp  Gly Ile His Arg Lys  His Pro Pro 
    2225                 2230                 2235             


Asn Tyr  Lys Lys Pro Val Leu  Phe Ser Phe Gln Pro  Asn His Phe 
    2240                 2245                 2250             


Phe Asn  Asn Asn Lys Val Gln  Leu Met Val Thr Asp  Ser Glu Leu 
    2255                 2260                 2265             


Ser Asn  Gln Phe Ser Ile Asp  Thr Val Gly Ser His  Gly Ala Val 
    2270                 2275                 2280             


Lys Cys  Lys Gly Leu Lys Met  Asp Tyr Gln Val Gly  Val Thr Ile 
    2285                 2290                 2295             


Asp Leu  Ser Ser Phe Asn Ile  Thr Arg Ile Val Thr  Phe Thr Pro 
    2300                 2305                 2310             


Phe Tyr  Met Ile Lys Asn Lys  Ser Lys Tyr His Ile  Ser Val Ala 
    2315                 2320                 2325             


Glu Glu  Gly Asn Asp Lys Trp  Leu Ser Leu Asp Leu  Glu Gln Cys 
    2330                 2335                 2340             


Ile Pro  Phe Trp Pro Glu Tyr  Ala Ser Ser Lys Leu  Leu Ile Gln 
    2345                 2350                 2355             


Val Glu  Arg Ser Glu Asp Pro  Pro Lys Arg Ile Tyr  Phe Asn Lys 
    2360                 2365                 2370             


Gln Glu  Asn Cys Ile Leu Leu  Arg Leu Asp Asn Glu  Leu Gly Gly 
    2375                 2380                 2385             


Ile Ile  Ala Glu Val Asn Leu  Ala Glu His Ser Thr  Val Ile Thr 
    2390                 2395                 2400             


Phe Leu  Asp Tyr His Asp Gly  Ala Ala Thr Phe Leu  Leu Ile Asn 
    2405                 2410                 2415             


His Thr  Lys Asn Glu Leu Val  Gln Tyr Asn Gln Ser  Ser Leu Ser 
    2420                 2425                 2430             


Glu Ile  Glu Asp Ser Leu Pro  Pro Gly Lys Ala Val  Phe Tyr Thr 
    2435                 2440                 2445             


Trp Ala  Asp Pro Val Gly Ser  Arg Arg Leu Lys Trp  Arg Cys Arg 
    2450                 2455                 2460             


Lys Ser  His Gly Glu Val Thr  Gln Lys Asp Asp Met  Met Met Pro 
    2465                 2470                 2475             


Ile Asp  Leu Gly Glu Lys Thr  Ile Tyr Leu Val Ser  Phe Phe Glu 
    2480                 2485                 2490             


Gly Leu  Gln Arg Ile Ile Leu  Phe Thr Glu Asp Pro  Arg Val Phe 
    2495                 2500                 2505             


Lys Val  Thr Tyr Glu Ser Glu  Lys Ala Glu Leu Ala  Glu Gln Glu 
    2510                 2515                 2520             


Ile Ala  Val Ala Leu Gln Asp  Val Gly Ile Ser Leu  Val Asn Asn 
    2525                 2530                 2535             


Tyr Thr  Lys Gln Glu Val Ala  Tyr Ile Gly Ile Thr  Ser Ser Asp 
    2540                 2545                 2550             


Val Val  Trp Glu Thr Lys Pro  Lys Lys Lys Ala Arg  Trp Lys Pro 
    2555                 2560                 2565             


Met Ser  Val Lys His Thr Glu  Lys Leu Glu Arg Glu  Phe Lys Glu 
    2570                 2575                 2580             


Tyr Thr  Glu Ser Ser Pro Ser  Glu Asp Lys Val Ile  Gln Leu Asp 
    2585                 2590                 2595             


Thr Asn  Val Pro Val Arg Leu  Thr Pro Thr Gly His  Asn Met Lys 
    2600                 2605                 2610             


Ile Leu  Gln Pro His Val Ile  Ala Leu Arg Arg Asn  Tyr Leu Pro 
    2615                 2620                 2625             


Ala Leu  Lys Val Glu Tyr Asn  Thr Ser Ala His Gln  Ser Ser Phe 
    2630                 2635                 2640             


Arg Ile  Gln Ile Tyr Arg Ile  Gln Ile Gln Asn Gln  Ile His Gly 
    2645                 2650                 2655             


Ala Val  Phe Pro Phe Val Phe  Tyr Pro Val Lys Pro  Pro Lys Ser 
    2660                 2665                 2670             


Val Thr  Met Asp Ser Ala Pro  Lys Pro Phe Thr Asp  Val Ser Ile 
    2675                 2680                 2685             


Val Met  Arg Ser Ala Gly His  Ser Gln Ile Ser Arg  Ile Lys Tyr 
    2690                 2695                 2700             


Phe Lys  Val Leu Ile Gln Glu  Met Asp Leu Arg Leu  Asp Leu Gly 
    2705                 2710                 2715             


Phe Ile  Tyr Ala Leu Thr Asp  Leu Met Thr Glu Ala  Glu Val Thr 
    2720                 2725                 2730             


Glu Asn  Thr Glu Val Glu Leu  Phe His Lys Asp Ile  Glu Ala Phe 
    2735                 2740                 2745             


Lys Glu  Glu Tyr Lys Thr Ala  Ser Leu Val Asp Gln  Ser Gln Val 
    2750                 2755                 2760             


Ser Leu  Tyr Glu Tyr Phe His  Ile Ser Pro Ile Lys  Leu His Leu 
    2765                 2770                 2775             


Ser Val  Ser Leu Ser Ser Gly  Arg Glu Glu Ala Lys  Asp Ser Lys 
    2780                 2785                 2790             


Gln Asn  Gly Gly Leu Ile Pro  Val His Ser Leu Asn  Leu Leu Leu 
    2795                 2800                 2805             


Lys Ser  Ile Gly Ala Thr Leu  Thr Asp Val Gln Asp  Val Val Phe 
    2810                 2815                 2820             


Lys Leu  Ala Phe Phe Glu Leu  Asn Tyr Gln Phe His  Thr Thr Ser 
    2825                 2830                 2835             


Asp Leu  Gln Ser Glu Val Ile  Arg His Tyr Ser Lys  Gln Ala Ile 
    2840                 2845                 2850             


Lys Gln  Met Tyr Val Leu Ile  Leu Gly Leu Asp Val  Leu Gly Asn 
    2855                 2860                 2865             


Pro Phe  Gly Leu Ile Arg Glu  Phe Ser Glu Gly Val  Glu Ala Phe 
    2870                 2875                 2880             


Phe Tyr  Glu Pro Tyr Gln Gly  Ala Ile Gln Gly Pro  Glu Glu Phe 
    2885                 2890                 2895             


Val Glu  Gly Met Ala Leu Gly  Leu Lys Ala Leu Val  Gly Gly Ala 
    2900                 2905                 2910             


Val Gly  Gly Leu Ala Gly Ala  Ala Ser Lys Ile Thr  Gly Ala Met 
    2915                 2920                 2925             


Ala Lys  Gly Val Ala Ala Met  Thr Met Asp Glu Asp  Tyr Gln Gln 
    2930                 2935                 2940             


Lys Arg  Arg Glu Ala Met Asn  Lys Gln Pro Ala Gly  Phe Arg Glu 
    2945                 2950                 2955             


Gly Ile  Thr Arg Gly Gly Lys  Gly Leu Val Ser Gly  Phe Val Ser 
    2960                 2965                 2970             


Gly Ile  Thr Gly Ile Val Thr  Lys Pro Ile Lys Gly  Ala Gln Lys 
    2975                 2980                 2985             


Gly Gly  Ala Ala Gly Phe Phe  Lys Gly Val Gly Lys  Gly Leu Val 
    2990                 2995                 3000             


Gly Ala  Val Ala Arg Pro Thr  Gly Gly Ile Ile Asp  Met Ala Ser 
    3005                 3010                 3015             


Ser Thr  Phe Gln Gly Ile Lys  Arg Ala Thr Glu Thr  Ser Glu Val 
    3020                 3025                 3030             


Glu Ser  Leu Arg Pro Pro Arg  Phe Phe Asn Glu Asp  Gly Val Ile 
    3035                 3040                 3045             


Arg Pro  Tyr Arg Leu Arg Asp  Gly Thr Gly Asn Gln  Met Leu Gln 
    3050                 3055                 3060             


Val Met  Glu Asn Gly Arg Phe  Ala Lys Tyr Lys Tyr  Phe Thr His 
    3065                 3070                 3075             


Val Met  Ile Asn Lys Thr Asp  Met Leu Met Ile Thr  Arg Arg Gly 
    3080                 3085                 3090             


Val Leu  Phe Val Thr Lys Gly  Thr Phe Gly Gln Leu  Thr Cys Glu 
    3095                 3100                 3105             


Trp Gln  Tyr Ser Phe Asp Glu  Phe Thr Lys Glu Pro  Phe Ile Val 
    3110                 3115                 3120             


His Gly  Arg Arg Leu Arg Ile  Glu Ala Lys Glu Arg  Val Lys Ser 
    3125                 3130                 3135             


Val Phe  His Ala Arg Glu Phe  Gly Lys Ile Ile Asn  Phe Lys Thr 
    3140                 3145                 3150             


Pro Glu  Asp Ala Arg Trp Ile  Leu Thr Lys Leu Gln  Glu Ala Arg 
    3155                 3160                 3165             


Glu Pro  Ser Pro Ser Leu 
    3170                 


<210>  16
<211>  9408
<212>  DNA
<213>  Homo sapiens

<400>  16
atggttttcg agtcggtggt cgtggacgtg ttgaaccggt tcttggggga ctatgtggtg     60

gacttggaca cgtcccagct ctctctgggc atctggaaag gagctgtggc cctcaagaat    120

cttcaaatta aagaaaatgc cctgagtcaa ctggatgtac catttaaagt taaagttggt    180

cacataggta atcttaaact tataattcca tggaaaaacc tttatactca acctgttgaa    240

gccgtattgg aagaaattta tttacttata gtgccttctt ctagaataaa atatgatcct    300

ttaaaagaag agaaacaact catggaagca aagcaacagg aactgaaaag aatagaagaa    360

gcaaaacaaa aagtagttga tcaagaacaa catctgccgg aaaaacagga cacttttgca    420

gaaaaattag ttacacagat cataaaaaat cttcaggtga aaatttccag tatccatatt    480

cgttatgaag atgatatcac aaatcgggac aaaccgctgt catttggtat ttcccttcaa    540

aatctgagca tgcagacaac tgatcaatac tgggttccat gtttacatga tgaaactgag    600

aaactggttc gtaagttaat ccgattggat aacctgtttg cctattggaa tgtgaagtct    660

cagatgtttt atcttagtga ttatgataac tccttggacg acttgaagaa tggcattgtc    720

aatgaaaata ttgttccaga aggttatgat tttgtatttc gtcccatatc tgctaatgcc    780

aaacttgtga tgaatcgccg atctgatttt gacttttctg cccccaaaat aaacttggaa    840

attgagttac ataacatagc aattgaattt aataaaccac agtatttcag tattatggag    900

cttcttgaat cagttgatat gatggcacaa aatctgccat ataggaagtt caaacctgat    960

gtgcctcttc accaccatgc cagagaatgg tgggcttatg ctatacatgg cgttcttgaa   1020

gtaaatgttt gccccaggtt atggatgtgg tcatggaagc atattagaaa acataggcaa   1080

aaagtgaagc aatataaaga actgtataaa aaaaagttaa caagtaagaa gccacctggt   1140

gaacttctcg tgtctttgga ggagttggaa aaaaccttgg atgtctttaa tataactata   1200

gctagacaga cggcagaagt tgaggtaaag aaagctggat acaaaattta caaagaagga   1260

gtaaaagatc cagaggataa taaagggtgg tttagctggc tatggtcttg gtcagaacaa   1320

aatactaatg aacagcaacc agatgttcaa cctgaaactc ttgaagaaat gttgacacct   1380

gaagaaaaag ctttactcta tgaagcaatt ggctatagtg aaacagcagt tgatccaact   1440

ttactaaaaa catttgaagc cttgaagttt tttgtccact tgaaaagtat gtctattgtt   1500

ctaagagaaa atcatcaaaa acctgagctg gtagatattg taatagaaga atttagcacc   1560

ttaattgtgc aaagaccagg agcacaagca ataaaatttg aaactaaaat agattcattt   1620

catattactg gcttaccaga taattcagaa aaaccccgcc tcctgtcttc attggatgat   1680

gcaatgtcac ttttccaaat tacatttgag ataaatccat tagatgaaac tgtttctcag   1740

aggtgtatca tagaagctga acctttagaa atcatatatg atgcaaggac agtgaatagt   1800

atagtggaat tcttcagacc tccaaaagag gtacatctag cacagctcac tgcagcaact   1860

ttgacaaaac tggaagaatt tcgcagtaag acagcaacag gtctactgta tattattgaa   1920

acacagaaag ttcttgatct caaaattaat ttgaaggctt catatattat tgtcccacaa   1980

gatggaattt ttagtcctac atcaaatctg cttcttttgg accttggtca tctaaaggtg   2040

acgagtaaaa gtcgttctga attaccagat gtgaaacaag gtgaggccaa tcttaaagag   2100

ataatggata gagcttatga ttcatttgat attcaactta caagtgtaca gctgctttac   2160

agtagagttg gtgataattg gagagaagca cgaaaactca gtgtatctac ccagcatatt   2220

ttggtaccca tgcacttcaa tttggaactg tctaaggcca tggttttcat ggatgtaagg   2280

atgcccaaat tcaagattta tggaaagtta cctcttattt ctttacgaat ctcagataaa   2340

aaactacaag ggattatgga attgattgaa agcattccaa aacctgaacc agtaactgaa   2400

gtatctgccc ctgtcaaatc attccagatt caaacatcta cttctttggg aacatcacag   2460

atttcacaga aaataattcc tctcttggaa cttccatctg tttctgaaga tgattcagag   2520

gaggaatttt ttgatgcacc atgtagtccc ttggaagaac ctcttcagtt tccaactgga   2580

gttaaaagta ttcgaaccag aaagttacaa aagcaggatt gttcagtaaa tatgactaca   2640

tttaaaataa gatttgaagt accaaaggtt ttgatcgagt tttatcacct tgttggagat   2700

tgtgaactat ctgtggtaga aattcttgtt ttaggattgg gtgcagaaat tgagattaga   2760

acatacgatt tgaaagcaaa tgcctttttg aaagagttct gcttaaaatg cccagaatac   2820

ttggatgaaa acaagaaacc agtttatttg gttacaaccc tggataacac aatggaagac   2880

ctgttaacgc tggaatatgt aaaggctgaa aagaatgtac ccgacttgaa aagtacctat   2940

aacaatgttt tacaattgat taaggtaaat ttttcctctt tggatattca tttacacact   3000

gaagcacttc tgaatacaat aaattatctt cataatatcc ttccgcaatc agaggaaaaa   3060

tcagccccag tgtccactac agagactgaa gacaaaggag atgtcattaa aaaattaggg   3120

cttgattctg agatgattat gaggccttca gaaactgaaa taaacgcaaa gctaaggaat   3180

ataattgttt tagattctga tataacagct atatacaaaa aggctgttta tatcactgga   3240

aaagaagttt tcagcttcaa aatggtttct tacatggatg caactgctgg ttctgcatac   3300

acagatatga atgtggttga cattcaggtt aatttaatag ttggttgcat tgaagtagtt   3360

tttgtcacga aatttctata ttctatattg gcttttatag ataattttca ggcagctaaa   3420

caagccttgg ctgaggcaac tgttcaggca gctggaatgg ctgctactgg tgtaaaagaa   3480

ctcgcacaaa ggagttccag aatggcactg gatattaaca tcaaagcccc agttgtggtc   3540

atcccgcagt ctccagtttc tgaaaatgtt tttgttgctg attttggact aattacaatg   3600

acaaatacct ttcatatgat aacagagagc cagagctctc ccccacctgt tattgatttg   3660

ataacaataa agctgagtga aatgcgacta tacagatctc gatttattaa tgatgcatac   3720

caggaagtac tggatctact cctgccatta aatcttgagg ttgtggttga acgaaattta   3780

tgctgggagt ggtaccagga agttccttgt tttaatgtaa atgctcagct gaaaccaatg   3840

gagttcattc ttagtcaaga agatataaca actattttta aaacattgca tggcaatata   3900

tggtatgaaa aagatggtag tgcctcacct gctgtaacaa aagaccaata cagtgccact   3960

agtggagtta ctactaatgc ttcacaccat tcaggaggag caactgtggt gacagctgct   4020

gtggtagaag tacattcacg tgccttacta gttaagacaa cactaaacat aagcttcaaa   4080

actgatgatc tcaccatggt gctgtatagt ccaggtccta aacaggcttc ctttacagat   4140

gttcgtgatc cttctctgaa acttgctgaa tttaaattgg agaatattat aagtacttta   4200

aaaatgtata cagatggctc aacattttct tccttctcat taaaaaactg tattttagat   4260

gataaaagac ctcatgtcaa gaaagcaact cctcgaatga taggactgac agttggtttt   4320

gacaaaaaag acatgatgga tataaagtac aggaaagtca gagatggttg tgtgactgat   4380

gcggtctttc aagaaatgta tatttgtgca agcgtagaat ttctgcagac tgttgcaaat   4440

gtctttcttg aggcctacac cacaggcact gctgtagaaa ccagtgtgca aacatggact   4500

gctaaggaag aagtacctac acaggaatca gtgaagtggg aaattaatgt tattattaaa   4560

aatcctgaaa ttgtgtttgt agctgacatg acaaaaaatg atgctcctgc tttagtcatt   4620

acaacacaat gtgaaatttg ctataaaggt aaccttgaaa atagtacaat gactgctgcc   4680

attaaagatc tccaagtgag agcctgcccg tttcttccag tcaagagaaa aggcaaaatc   4740

actactgttt tgcagccctg tgacttgttt tatcaaacta ctcagaaagg tacagatcca   4800

caagtgatcg atatgtcagt aaaatccctg acactaaagg tttcaccagt tattataaat   4860

actatgatta ccataacttc agcactgtat acaactaagg aaaccatccc agaagaaacg   4920

gcttcttcta ctgcacattt atgggaaaag aaggatacaa agactttaaa aatgtggttt   4980

cttgaagaat caaatgaaac tgaaaaaata gctcccacaa ctgaattggt acccaaaggc   5040

gagatgataa aaatgaacat tgattctatt tttatagttc ttgaggctgg aattggtcat   5100

agaacagtac ctatgcttct ggcaaagtca cgtttttcag gggaaggcaa aaactggagt   5160

tccctaataa atctgcactg tcagcttgag ctagaagtgc attattataa tgaaatgttt   5220

ggtgtatggg agcctttgct tgaaccctta gaaattgatc agactgagga ttttagacca   5280

tggaatcttg gtatcaagat gaaaaagaaa gcaaaaatgg ccattgttga gtcagatcct   5340

gaagaagaaa actacaaagt gccagaatat aaaactgtca tcagtttcca ttcaaaagac   5400

caattaaaca ttacattatc caaatgtggt cttgtaatgt taaacaattt agtcaaggca   5460

tttacagaag ctgccactgg atcttcagct gacttcgtaa aggatctagc accatttatg   5520

attttaaatt cccttggact tactatttct gtttcgccaa gtgattcttt tagtgtactc   5580

aacattccta tggcaaaatc atatgtattg aaaaatggag aaagtttaag tatggattat   5640

atccgaacca aggacaatga tcatttcaat gcaatgacca gcctaagcag caaactcttc   5700

ttcattcttc ttacacctgt taaccattct actgctgata agattccttt aacaaaagtg   5760

ggacgacgtc tgtacactgt aagacacaga gagtctggcg ttgaaagatc tattgtttgt   5820

caaattgata cagtagaagg aagtaagaag gtcacaattc gctccccagt gcagataaga   5880

aatcattttt cagtcccact gtctgtttac gaaggggata ccttattggg aactgcctca   5940

cctgaaaatg aattcaacat accattagga tcttaccgat cattcatttt tctgaagcca   6000

gaagatgaga actatcaaat gtgtgaagga attgactttg aagagattat aaaaaatgat   6060

ggtgctcttc taaagaagaa atgtagatct aaaaaccctt ctaaggaatc atttctcatt   6120

aatattgttc cagaaaaaga taatttaaca tctctatcag tgtattcaga agatggttgg   6180

gatttaccat acataatgca tttgtggcca cctatcctgc tccgaaatct tcttccttac   6240

aaaattgctt attatataga gggaattgaa aattcggttt ttactctaag tgaaggacat   6300

tcagcccaga tttgtactgc acagttgggt aaagccaggc tacatttaaa attacttgac   6360

tatctcaatc acgattggaa aagtgaatat cacataaagc ctaatcagca agacattagt   6420

tttgtcagtt ttacttgtgt tacagaaatg gaaaagactg atttagatat tgctgtccat   6480

atgacttaca atactggtca gacagttgtg gcatttcata gtccttattg gatggtcaat   6540

aaaactggcc gcatgttaca gtacaaagca gacggaattc atcgaaagca tccacctaat   6600

tataaaaagc cagttctctt ttcttttcag ccaaatcact tttttaataa caataaggtt   6660

caacttatgg taactgatag tgagttgtcc aatcagtttt caattgatac tgttggtagt   6720

catggagctg ttaaatgtaa aggcctgaaa atggactatc aagttggtgt cactatagac   6780

ctgagcagtt ttaacattac tagaattgtg acatttaccc ctttttatat gattaaaaac   6840

aaaagcaaat accatatatc agtggctgaa gaaggaaatg ataaatggct ctctcttgat   6900

ttggagcagt gtatcccctt ttggcctgag tatgcttcta gtaaacttct tattcaagtc   6960

gaaaggagtg aagatcctcc caaaaggata tattttaaca agcaggaaaa ttgtattcta   7020

ttgcgtctag ataacgagct tggaggtatt atagcagaag tgaatttggc cgagcattct   7080

acagttatta catttttaga ttatcatgat ggagcagcta cattcctctt aataaatcac   7140

acaaagaatg aacttgttca atacaatcaa agttctctca gtgaaataga agattccctc   7200

cctcctggta aagccgtgtt ttatacatgg gctgatccgg tgggctctag aaggctgaag   7260

tggagatgta gaaaaagcca tggtgaagta acacagaagg atgatatgat gatgcctata   7320

gatttggggg aaaagacaat atatttagtt tcattctttg aaggtttaca acgcattatt   7380

ttattcactg aagatccaag ggtatttaaa gtaacatatg aaagtgagaa agcagagtta   7440

gcagagcaag aaattgcagt ggcattacaa gatgttggaa tttctcttgt caacaattac   7500

acgaagcaag aagtagccta tataggcatt acaagttctg atgtggtttg ggaaacaaag   7560

cccaagaaga aggcaagatg gaagccaatg agtgtaaagc acactgagaa gttagagaga   7620

gaatttaagg aatatactga atcttctcct tcagaagata aggttattca gttggacact   7680

aatgttccgg ttcgcctaac ccctactggt cataacatga aaattctgca gccgcatgta   7740

atagctctac gaagaaatta tcttccagca ttaaaagtgg aatataacac atctgcacat   7800

caatcatcat ttagaattca gatttacaga atacagatcc aaaatcagat acatggtgct   7860

gtatttccct ttgtgtttta tcctgttaaa cctccaaagt cggtcaccat ggattcagca   7920

ccaaagccct ttacagatgt cagtattgtc atgagatctg caggacattc ccagatatca   7980

cgtattaagt atttcaaagt attgattcaa gaaatggatc tcaggttaga tcttgggttt   8040

atctatgctt taacagacct tatgacagaa gctgaggtga ctgaaaatac agaggttgag   8100

ctttttcata aagatataga agctttcaaa gaagaatata aaacagcctc attagtagat   8160

caatcacaag tcagcctcta tgaatatttt catatatctc ctatcaagtt acatttaagt   8220

gtttcactga gttccggcag agaagaagct aaagattcaa aacaaaatgg aggactgatt   8280

ccagttcatt ctttaaatct tttgctgaag agtattggtg ccacactgac agatgtacaa   8340

gatgtagttt ttaagcttgc attttttgaa ctcaactatc agttccatac aacatccgat   8400

ctacagtctg aagtcataag acactattca aaacaggcca ttaagcagat gtatgtactc   8460

attcttggac ttgatgtttt gggaaatcca tttggcttaa ttagagaatt ttctgaaggt   8520

gtagaagcat ttttttatga accttaccag ggagccatcc agggtcctga agagtttgtg   8580

gaaggaatgg cactaggact taaggcacta gttggtggag ctgttggtgg attggctggt   8640

gctgcctcca aaatcaccgg tgctatggct aagggggtag cagctatgac catggatgaa   8700

gactaccaac agaagagaag agaagccatg aataagcaac cagctggttt tagagaaggc   8760

atcactcgtg gaggaaaagg cttagtttct ggatttgtta gtggcataac aggaattgtt   8820

acaaaaccaa tcaaaggagc tcaaaaagga ggagcagctg gtttctttaa aggtgttggg   8880

aaaggtttag taggagcggt agcaaggcca actggaggca tcatagacat ggctagcagt   8940

acatttcagg gaataaaaag agctacagag acttctgaag tggagagtct gcgacctcct   9000

cggttcttca atgaagatgg agttatcaga ccgtacaggt tgagggatgg gactggaaat   9060

caaatgttac aggtcatgga aaatggaaga tttgcaaaat acaaatattt tacccatgtc   9120

atgatcaata agacagatat gctaatgata accagacgtg gtgtattgtt tgtaacaaag   9180

ggaacatttg gacaactcac gtgtgagtgg cagtatagtt ttgatgaatt taccaaagag   9240

ccattcattg ttcatgggag aagattgcgc attgaagcaa aggaacgagt gaagtctgta   9300

tttcatgcca gagagtttgg aaaaataatt aacttcaaga ccccagagga tgccaggtgg   9360

atcctcacaa agctacaaga agcaagagaa ccttctccga gcctctga                9408


<210>  17
<211>  3135
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Val Phe Glu Ser Val Val Val Asp Val Leu Asn Arg Phe Leu Gly 
1               5                   10                  15      


Asp Tyr Val Val Asp Leu Asp Thr Ser Gln Leu Ser Leu Gly Ile Trp 
            20                  25                  30          


Lys Gly Ala Val Ala Leu Lys Asn Leu Gln Ile Lys Glu Asn Ala Leu 
        35                  40                  45              


Ser Gln Leu Asp Val Pro Phe Lys Val Lys Val Gly His Ile Gly Asn 
    50                  55                  60                  


Leu Lys Leu Ile Ile Pro Trp Lys Asn Leu Tyr Thr Gln Pro Val Glu 
65                  70                  75                  80  


Ala Val Leu Glu Glu Ile Tyr Leu Leu Ile Val Pro Ser Ser Arg Ile 
                85                  90                  95      


Lys Tyr Asp Pro Leu Lys Glu Glu Lys Gln Leu Met Glu Ala Lys Gln 
            100                 105                 110         


Gln Glu Leu Lys Arg Ile Glu Glu Ala Lys Gln Lys Val Val Asp Gln 
        115                 120                 125             


Glu Gln His Leu Pro Glu Lys Gln Asp Thr Phe Ala Glu Lys Leu Val 
    130                 135                 140                 


Thr Gln Ile Ile Lys Asn Leu Gln Val Lys Ile Ser Ser Ile His Ile 
145                 150                 155                 160 


Arg Tyr Glu Asp Asp Ile Thr Asn Arg Asp Lys Pro Leu Ser Phe Gly 
                165                 170                 175     


Ile Ser Leu Gln Asn Leu Ser Met Gln Thr Thr Asp Gln Tyr Trp Val 
            180                 185                 190         


Pro Cys Leu His Asp Glu Thr Glu Lys Leu Val Arg Lys Leu Ile Arg 
        195                 200                 205             


Leu Asp Asn Leu Phe Ala Tyr Trp Asn Val Lys Ser Gln Met Phe Tyr 
    210                 215                 220                 


Leu Ser Asp Tyr Asp Asn Ser Leu Asp Asp Leu Lys Asn Gly Ile Val 
225                 230                 235                 240 


Asn Glu Asn Ile Val Pro Glu Gly Tyr Asp Phe Val Phe Arg Pro Ile 
                245                 250                 255     


Ser Ala Asn Ala Lys Leu Val Met Asn Arg Arg Ser Asp Phe Asp Phe 
            260                 265                 270         


Ser Ala Pro Lys Ile Asn Leu Glu Ile Glu Leu His Asn Ile Ala Ile 
        275                 280                 285             


Glu Phe Asn Lys Pro Gln Tyr Phe Ser Ile Met Glu Leu Leu Glu Ser 
    290                 295                 300                 


Val Asp Met Met Ala Gln Asn Leu Pro Tyr Arg Lys Phe Lys Pro Asp 
305                 310                 315                 320 


Val Pro Leu His His His Ala Arg Glu Trp Trp Ala Tyr Ala Ile His 
                325                 330                 335     


Gly Val Leu Glu Val Asn Val Cys Pro Arg Leu Trp Met Trp Ser Trp 
            340                 345                 350         


Lys His Ile Arg Lys His Arg Gln Lys Val Lys Gln Tyr Lys Glu Leu 
        355                 360                 365             


Tyr Lys Lys Lys Leu Thr Ser Lys Lys Pro Pro Gly Glu Leu Leu Val 
    370                 375                 380                 


Ser Leu Glu Glu Leu Glu Lys Thr Leu Asp Val Phe Asn Ile Thr Ile 
385                 390                 395                 400 


Ala Arg Gln Thr Ala Glu Val Glu Val Lys Lys Ala Gly Tyr Lys Ile 
                405                 410                 415     


Tyr Lys Glu Gly Val Lys Asp Pro Glu Asp Asn Lys Gly Trp Phe Ser 
            420                 425                 430         


Trp Leu Trp Ser Trp Ser Glu Gln Asn Thr Asn Glu Gln Gln Pro Asp 
        435                 440                 445             


Val Gln Pro Glu Thr Leu Glu Glu Met Leu Thr Pro Glu Glu Lys Ala 
    450                 455                 460                 


Leu Leu Tyr Glu Ala Ile Gly Tyr Ser Glu Thr Ala Val Asp Pro Thr 
465                 470                 475                 480 


Leu Leu Lys Thr Phe Glu Ala Leu Lys Phe Phe Val His Leu Lys Ser 
                485                 490                 495     


Met Ser Ile Val Leu Arg Glu Asn His Gln Lys Pro Glu Leu Val Asp 
            500                 505                 510         


Ile Val Ile Glu Glu Phe Ser Thr Leu Ile Val Gln Arg Pro Gly Ala 
        515                 520                 525             


Gln Ala Ile Lys Phe Glu Thr Lys Ile Asp Ser Phe His Ile Thr Gly 
    530                 535                 540                 


Leu Pro Asp Asn Ser Glu Lys Pro Arg Leu Leu Ser Ser Leu Asp Asp 
545                 550                 555                 560 


Ala Met Ser Leu Phe Gln Ile Thr Phe Glu Ile Asn Pro Leu Asp Glu 
                565                 570                 575     


Thr Val Ser Gln Arg Cys Ile Ile Glu Ala Glu Pro Leu Glu Ile Ile 
            580                 585                 590         


Tyr Asp Ala Arg Thr Val Asn Ser Ile Val Glu Phe Phe Arg Pro Pro 
        595                 600                 605             


Lys Glu Val His Leu Ala Gln Leu Thr Ala Ala Thr Leu Thr Lys Leu 
    610                 615                 620                 


Glu Glu Phe Arg Ser Lys Thr Ala Thr Gly Leu Leu Tyr Ile Ile Glu 
625                 630                 635                 640 


Thr Gln Lys Val Leu Asp Leu Lys Ile Asn Leu Lys Ala Ser Tyr Ile 
                645                 650                 655     


Ile Val Pro Gln Asp Gly Ile Phe Ser Pro Thr Ser Asn Leu Leu Leu 
            660                 665                 670         


Leu Asp Leu Gly His Leu Lys Val Thr Ser Lys Ser Arg Ser Glu Leu 
        675                 680                 685             


Pro Asp Val Lys Gln Gly Glu Ala Asn Leu Lys Glu Ile Met Asp Arg 
    690                 695                 700                 


Ala Tyr Asp Ser Phe Asp Ile Gln Leu Thr Ser Val Gln Leu Leu Tyr 
705                 710                 715                 720 


Ser Arg Val Gly Asp Asn Trp Arg Glu Ala Arg Lys Leu Ser Val Ser 
                725                 730                 735     


Thr Gln His Ile Leu Val Pro Met His Phe Asn Leu Glu Leu Ser Lys 
            740                 745                 750         


Ala Met Val Phe Met Asp Val Arg Met Pro Lys Phe Lys Ile Tyr Gly 
        755                 760                 765             


Lys Leu Pro Leu Ile Ser Leu Arg Ile Ser Asp Lys Lys Leu Gln Gly 
    770                 775                 780                 


Ile Met Glu Leu Ile Glu Ser Ile Pro Lys Pro Glu Pro Val Thr Glu 
785                 790                 795                 800 


Val Ser Ala Pro Val Lys Ser Phe Gln Ile Gln Thr Ser Thr Ser Leu 
                805                 810                 815     


Gly Thr Ser Gln Ile Ser Gln Lys Ile Ile Pro Leu Leu Glu Leu Pro 
            820                 825                 830         


Ser Val Ser Glu Asp Asp Ser Glu Glu Glu Phe Phe Asp Ala Pro Cys 
        835                 840                 845             


Ser Pro Leu Glu Glu Pro Leu Gln Phe Pro Thr Gly Val Lys Ser Ile 
    850                 855                 860                 


Arg Thr Arg Lys Leu Gln Lys Gln Asp Cys Ser Val Asn Met Thr Thr 
865                 870                 875                 880 


Phe Lys Ile Arg Phe Glu Val Pro Lys Val Leu Ile Glu Phe Tyr His 
                885                 890                 895     


Leu Val Gly Asp Cys Glu Leu Ser Val Val Glu Ile Leu Val Leu Gly 
            900                 905                 910         


Leu Gly Ala Glu Ile Glu Ile Arg Thr Tyr Asp Leu Lys Ala Asn Ala 
        915                 920                 925             


Phe Leu Lys Glu Phe Cys Leu Lys Cys Pro Glu Tyr Leu Asp Glu Asn 
    930                 935                 940                 


Lys Lys Pro Val Tyr Leu Val Thr Thr Leu Asp Asn Thr Met Glu Asp 
945                 950                 955                 960 


Leu Leu Thr Leu Glu Tyr Val Lys Ala Glu Lys Asn Val Pro Asp Leu 
                965                 970                 975     


Lys Ser Thr Tyr Asn Asn Val Leu Gln Leu Ile Lys Val Asn Phe Ser 
            980                 985                 990         


Ser Leu Asp Ile His Leu His Thr  Glu Ala Leu Leu Asn  Thr Ile Asn 
        995                 1000                 1005             


Tyr Leu  His Asn Ile Leu Pro  Gln Ser Glu Glu Lys  Ser Ala Pro 
    1010                 1015                 1020             


Val Ser  Thr Thr Glu Thr Glu  Asp Lys Gly Asp Val  Ile Lys Lys 
    1025                 1030                 1035             


Leu Gly  Leu Asp Ser Glu Met  Ile Met Arg Pro Ser  Glu Thr Glu 
    1040                 1045                 1050             


Ile Asn  Ala Lys Leu Arg Asn  Ile Ile Val Leu Asp  Ser Asp Ile 
    1055                 1060                 1065             


Thr Ala  Ile Tyr Lys Lys Ala  Val Tyr Ile Thr Gly  Lys Glu Val 
    1070                 1075                 1080             


Phe Ser  Phe Lys Met Val Ser  Tyr Met Asp Ala Thr  Ala Gly Ser 
    1085                 1090                 1095             


Ala Tyr  Thr Asp Met Asn Val  Val Asp Ile Gln Val  Asn Leu Ile 
    1100                 1105                 1110             


Val Gly  Cys Ile Glu Val Val  Phe Val Thr Lys Phe  Leu Tyr Ser 
    1115                 1120                 1125             


Ile Leu  Ala Phe Ile Asp Asn  Phe Gln Ala Ala Lys  Gln Ala Leu 
    1130                 1135                 1140             


Ala Glu  Ala Thr Val Gln Ala  Ala Gly Met Ala Ala  Thr Gly Val 
    1145                 1150                 1155             


Lys Glu  Leu Ala Gln Arg Ser  Ser Arg Met Ala Leu  Asp Ile Asn 
    1160                 1165                 1170             


Ile Lys  Ala Pro Val Val Val  Ile Pro Gln Ser Pro  Val Ser Glu 
    1175                 1180                 1185             


Asn Val  Phe Val Ala Asp Phe  Gly Leu Ile Thr Met  Thr Asn Thr 
    1190                 1195                 1200             


Phe His  Met Ile Thr Glu Ser  Gln Ser Ser Pro Pro  Pro Val Ile 
    1205                 1210                 1215             


Asp Leu  Ile Thr Ile Lys Leu  Ser Glu Met Arg Leu  Tyr Arg Ser 
    1220                 1225                 1230             


Arg Phe  Ile Asn Asp Ala Tyr  Gln Glu Val Leu Asp  Leu Leu Leu 
    1235                 1240                 1245             


Pro Leu  Asn Leu Glu Val Val  Val Glu Arg Asn Leu  Cys Trp Glu 
    1250                 1255                 1260             


Trp Tyr  Gln Glu Val Pro Cys  Phe Asn Val Asn Ala  Gln Leu Lys 
    1265                 1270                 1275             


Pro Met  Glu Phe Ile Leu Ser  Gln Glu Asp Ile Thr  Thr Ile Phe 
    1280                 1285                 1290             


Lys Thr  Leu His Gly Asn Ile  Trp Tyr Glu Lys Asp  Gly Ser Ala 
    1295                 1300                 1305             


Ser Pro  Ala Val Thr Lys Asp  Gln Tyr Ser Ala Thr  Ser Gly Val 
    1310                 1315                 1320             


Thr Thr  Asn Ala Ser His His  Ser Gly Gly Ala Thr  Val Val Thr 
    1325                 1330                 1335             


Ala Ala  Val Val Glu Val His  Ser Arg Ala Leu Leu  Val Lys Thr 
    1340                 1345                 1350             


Thr Leu  Asn Ile Ser Phe Lys  Thr Asp Asp Leu Thr  Met Val Leu 
    1355                 1360                 1365             


Tyr Ser  Pro Gly Pro Lys Gln  Ala Ser Phe Thr Asp  Val Arg Asp 
    1370                 1375                 1380             


Pro Ser  Leu Lys Leu Ala Glu  Phe Lys Leu Glu Asn  Ile Ile Ser 
    1385                 1390                 1395             


Thr Leu  Lys Met Tyr Thr Asp  Gly Ser Thr Phe Ser  Ser Phe Ser 
    1400                 1405                 1410             


Leu Lys  Asn Cys Ile Leu Asp  Asp Lys Arg Pro His  Val Lys Lys 
    1415                 1420                 1425             


Ala Thr  Pro Arg Met Ile Gly  Leu Thr Val Gly Phe  Asp Lys Lys 
    1430                 1435                 1440             


Asp Met  Met Asp Ile Lys Tyr  Arg Lys Val Arg Asp  Gly Cys Val 
    1445                 1450                 1455             


Thr Asp  Ala Val Phe Gln Glu  Met Tyr Ile Cys Ala  Ser Val Glu 
    1460                 1465                 1470             


Phe Leu  Gln Thr Val Ala Asn  Val Phe Leu Glu Ala  Tyr Thr Thr 
    1475                 1480                 1485             


Gly Thr  Ala Val Glu Thr Ser  Val Gln Thr Trp Thr  Ala Lys Glu 
    1490                 1495                 1500             


Glu Val  Pro Thr Gln Glu Ser  Val Lys Trp Glu Ile  Asn Val Ile 
    1505                 1510                 1515             


Ile Lys  Asn Pro Glu Ile Val  Phe Val Ala Asp Met  Thr Lys Asn 
    1520                 1525                 1530             


Asp Ala  Pro Ala Leu Val Ile  Thr Thr Gln Cys Glu  Ile Cys Tyr 
    1535                 1540                 1545             


Lys Gly  Asn Leu Glu Asn Ser  Thr Met Thr Ala Ala  Ile Lys Asp 
    1550                 1555                 1560             


Leu Gln  Val Arg Ala Cys Pro  Phe Leu Pro Val Lys  Arg Lys Gly 
    1565                 1570                 1575             


Lys Ile  Thr Thr Val Leu Gln  Pro Cys Asp Leu Phe  Tyr Gln Thr 
    1580                 1585                 1590             


Thr Gln  Lys Gly Thr Asp Pro  Gln Val Ile Asp Met  Ser Val Lys 
    1595                 1600                 1605             


Ser Leu  Thr Leu Lys Val Ser  Pro Val Ile Ile Asn  Thr Met Ile 
    1610                 1615                 1620             


Thr Ile  Thr Ser Ala Leu Tyr  Thr Thr Lys Glu Thr  Ile Pro Glu 
    1625                 1630                 1635             


Glu Thr  Ala Ser Ser Thr Ala  His Leu Trp Glu Lys  Lys Asp Thr 
    1640                 1645                 1650             


Lys Thr  Leu Lys Met Trp Phe  Leu Glu Glu Ser Asn  Glu Thr Glu 
    1655                 1660                 1665             


Lys Ile  Ala Pro Thr Thr Glu  Leu Val Pro Lys Gly  Glu Met Ile 
    1670                 1675                 1680             


Lys Met  Asn Ile Asp Ser Ile  Phe Ile Val Leu Glu  Ala Gly Ile 
    1685                 1690                 1695             


Gly His  Arg Thr Val Pro Met  Leu Leu Ala Lys Ser  Arg Phe Ser 
    1700                 1705                 1710             


Gly Glu  Gly Lys Asn Trp Ser  Ser Leu Ile Asn Leu  His Cys Gln 
    1715                 1720                 1725             


Leu Glu  Leu Glu Val His Tyr  Tyr Asn Glu Met Phe  Gly Val Trp 
    1730                 1735                 1740             


Glu Pro  Leu Leu Glu Pro Leu  Glu Ile Asp Gln Thr  Glu Asp Phe 
    1745                 1750                 1755             


Arg Pro  Trp Asn Leu Gly Ile  Lys Met Lys Lys Lys  Ala Lys Met 
    1760                 1765                 1770             


Ala Ile  Val Glu Ser Asp Pro  Glu Glu Glu Asn Tyr  Lys Val Pro 
    1775                 1780                 1785             


Glu Tyr  Lys Thr Val Ile Ser  Phe His Ser Lys Asp  Gln Leu Asn 
    1790                 1795                 1800             


Ile Thr  Leu Ser Lys Cys Gly  Leu Val Met Leu Asn  Asn Leu Val 
    1805                 1810                 1815             


Lys Ala  Phe Thr Glu Ala Ala  Thr Gly Ser Ser Ala  Asp Phe Val 
    1820                 1825                 1830             


Lys Asp  Leu Ala Pro Phe Met  Ile Leu Asn Ser Leu  Gly Leu Thr 
    1835                 1840                 1845             


Ile Ser  Val Ser Pro Ser Asp  Ser Phe Ser Val Leu  Asn Ile Pro 
    1850                 1855                 1860             


Met Ala  Lys Ser Tyr Val Leu  Lys Asn Gly Glu Ser  Leu Ser Met 
    1865                 1870                 1875             


Asp Tyr  Ile Arg Thr Lys Asp  Asn Asp His Phe Asn  Ala Met Thr 
    1880                 1885                 1890             


Ser Leu  Ser Ser Lys Leu Phe  Phe Ile Leu Leu Thr  Pro Val Asn 
    1895                 1900                 1905             


His Ser  Thr Ala Asp Lys Ile  Pro Leu Thr Lys Val  Gly Arg Arg 
    1910                 1915                 1920             


Leu Tyr  Thr Val Arg His Arg  Glu Ser Gly Val Glu  Arg Ser Ile 
    1925                 1930                 1935             


Val Cys  Gln Ile Asp Thr Val  Glu Gly Ser Lys Lys  Val Thr Ile 
    1940                 1945                 1950             


Arg Ser  Pro Val Gln Ile Arg  Asn His Phe Ser Val  Pro Leu Ser 
    1955                 1960                 1965             


Val Tyr  Glu Gly Asp Thr Leu  Leu Gly Thr Ala Ser  Pro Glu Asn 
    1970                 1975                 1980             


Glu Phe  Asn Ile Pro Leu Gly  Ser Tyr Arg Ser Phe  Ile Phe Leu 
    1985                 1990                 1995             


Lys Pro  Glu Asp Glu Asn Tyr  Gln Met Cys Glu Gly  Ile Asp Phe 
    2000                 2005                 2010             


Glu Glu  Ile Ile Lys Asn Asp  Gly Ala Leu Leu Lys  Lys Lys Cys 
    2015                 2020                 2025             


Arg Ser  Lys Asn Pro Ser Lys  Glu Ser Phe Leu Ile  Asn Ile Val 
    2030                 2035                 2040             


Pro Glu  Lys Asp Asn Leu Thr  Ser Leu Ser Val Tyr  Ser Glu Asp 
    2045                 2050                 2055             


Gly Trp  Asp Leu Pro Tyr Ile  Met His Leu Trp Pro  Pro Ile Leu 
    2060                 2065                 2070             


Leu Arg  Asn Leu Leu Pro Tyr  Lys Ile Ala Tyr Tyr  Ile Glu Gly 
    2075                 2080                 2085             


Ile Glu  Asn Ser Val Phe Thr  Leu Ser Glu Gly His  Ser Ala Gln 
    2090                 2095                 2100             


Ile Cys  Thr Ala Gln Leu Gly  Lys Ala Arg Leu His  Leu Lys Leu 
    2105                 2110                 2115             


Leu Asp  Tyr Leu Asn His Asp  Trp Lys Ser Glu Tyr  His Ile Lys 
    2120                 2125                 2130             


Pro Asn  Gln Gln Asp Ile Ser  Phe Val Ser Phe Thr  Cys Val Thr 
    2135                 2140                 2145             


Glu Met  Glu Lys Thr Asp Leu  Asp Ile Ala Val His  Met Thr Tyr 
    2150                 2155                 2160             


Asn Thr  Gly Gln Thr Val Val  Ala Phe His Ser Pro  Tyr Trp Met 
    2165                 2170                 2175             


Val Asn  Lys Thr Gly Arg Met  Leu Gln Tyr Lys Ala  Asp Gly Ile 
    2180                 2185                 2190             


His Arg  Lys His Pro Pro Asn  Tyr Lys Lys Pro Val  Leu Phe Ser 
    2195                 2200                 2205             


Phe Gln  Pro Asn His Phe Phe  Asn Asn Asn Lys Val  Gln Leu Met 
    2210                 2215                 2220             


Val Thr  Asp Ser Glu Leu Ser  Asn Gln Phe Ser Ile  Asp Thr Val 
    2225                 2230                 2235             


Gly Ser  His Gly Ala Val Lys  Cys Lys Gly Leu Lys  Met Asp Tyr 
    2240                 2245                 2250             


Gln Val  Gly Val Thr Ile Asp  Leu Ser Ser Phe Asn  Ile Thr Arg 
    2255                 2260                 2265             


Ile Val  Thr Phe Thr Pro Phe  Tyr Met Ile Lys Asn  Lys Ser Lys 
    2270                 2275                 2280             


Tyr His  Ile Ser Val Ala Glu  Glu Gly Asn Asp Lys  Trp Leu Ser 
    2285                 2290                 2295             


Leu Asp  Leu Glu Gln Cys Ile  Pro Phe Trp Pro Glu  Tyr Ala Ser 
    2300                 2305                 2310             


Ser Lys  Leu Leu Ile Gln Val  Glu Arg Ser Glu Asp  Pro Pro Lys 
    2315                 2320                 2325             


Arg Ile  Tyr Phe Asn Lys Gln  Glu Asn Cys Ile Leu  Leu Arg Leu 
    2330                 2335                 2340             


Asp Asn  Glu Leu Gly Gly Ile  Ile Ala Glu Val Asn  Leu Ala Glu 
    2345                 2350                 2355             


His Ser  Thr Val Ile Thr Phe  Leu Asp Tyr His Asp  Gly Ala Ala 
    2360                 2365                 2370             


Thr Phe  Leu Leu Ile Asn His  Thr Lys Asn Glu Leu  Val Gln Tyr 
    2375                 2380                 2385             


Asn Gln  Ser Ser Leu Ser Glu  Ile Glu Asp Ser Leu  Pro Pro Gly 
    2390                 2395                 2400             


Lys Ala  Val Phe Tyr Thr Trp  Ala Asp Pro Val Gly  Ser Arg Arg 
    2405                 2410                 2415             


Leu Lys  Trp Arg Cys Arg Lys  Ser His Gly Glu Val  Thr Gln Lys 
    2420                 2425                 2430             


Asp Asp  Met Met Met Pro Ile  Asp Leu Gly Glu Lys  Thr Ile Tyr 
    2435                 2440                 2445             


Leu Val  Ser Phe Phe Glu Gly  Leu Gln Arg Ile Ile  Leu Phe Thr 
    2450                 2455                 2460             


Glu Asp  Pro Arg Val Phe Lys  Val Thr Tyr Glu Ser  Glu Lys Ala 
    2465                 2470                 2475             


Glu Leu  Ala Glu Gln Glu Ile  Ala Val Ala Leu Gln  Asp Val Gly 
    2480                 2485                 2490             


Ile Ser  Leu Val Asn Asn Tyr  Thr Lys Gln Glu Val  Ala Tyr Ile 
    2495                 2500                 2505             


Gly Ile  Thr Ser Ser Asp Val  Val Trp Glu Thr Lys  Pro Lys Lys 
    2510                 2515                 2520             


Lys Ala  Arg Trp Lys Pro Met  Ser Val Lys His Thr  Glu Lys Leu 
    2525                 2530                 2535             


Glu Arg  Glu Phe Lys Glu Tyr  Thr Glu Ser Ser Pro  Ser Glu Asp 
    2540                 2545                 2550             


Lys Val  Ile Gln Leu Asp Thr  Asn Val Pro Val Arg  Leu Thr Pro 
    2555                 2560                 2565             


Thr Gly  His Asn Met Lys Ile  Leu Gln Pro His Val  Ile Ala Leu 
    2570                 2575                 2580             


Arg Arg  Asn Tyr Leu Pro Ala  Leu Lys Val Glu Tyr  Asn Thr Ser 
    2585                 2590                 2595             


Ala His  Gln Ser Ser Phe Arg  Ile Gln Ile Tyr Arg  Ile Gln Ile 
    2600                 2605                 2610             


Gln Asn  Gln Ile His Gly Ala  Val Phe Pro Phe Val  Phe Tyr Pro 
    2615                 2620                 2625             


Val Lys  Pro Pro Lys Ser Val  Thr Met Asp Ser Ala  Pro Lys Pro 
    2630                 2635                 2640             


Phe Thr  Asp Val Ser Ile Val  Met Arg Ser Ala Gly  His Ser Gln 
    2645                 2650                 2655             


Ile Ser  Arg Ile Lys Tyr Phe  Lys Val Leu Ile Gln  Glu Met Asp 
    2660                 2665                 2670             


Leu Arg  Leu Asp Leu Gly Phe  Ile Tyr Ala Leu Thr  Asp Leu Met 
    2675                 2680                 2685             


Thr Glu  Ala Glu Val Thr Glu  Asn Thr Glu Val Glu  Leu Phe His 
    2690                 2695                 2700             


Lys Asp  Ile Glu Ala Phe Lys  Glu Glu Tyr Lys Thr  Ala Ser Leu 
    2705                 2710                 2715             


Val Asp  Gln Ser Gln Val Ser  Leu Tyr Glu Tyr Phe  His Ile Ser 
    2720                 2725                 2730             


Pro Ile  Lys Leu His Leu Ser  Val Ser Leu Ser Ser  Gly Arg Glu 
    2735                 2740                 2745             


Glu Ala  Lys Asp Ser Lys Gln  Asn Gly Gly Leu Ile  Pro Val His 
    2750                 2755                 2760             


Ser Leu  Asn Leu Leu Leu Lys  Ser Ile Gly Ala Thr  Leu Thr Asp 
    2765                 2770                 2775             


Val Gln  Asp Val Val Phe Lys  Leu Ala Phe Phe Glu  Leu Asn Tyr 
    2780                 2785                 2790             


Gln Phe  His Thr Thr Ser Asp  Leu Gln Ser Glu Val  Ile Arg His 
    2795                 2800                 2805             


Tyr Ser  Lys Gln Ala Ile Lys  Gln Met Tyr Val Leu  Ile Leu Gly 
    2810                 2815                 2820             


Leu Asp  Val Leu Gly Asn Pro  Phe Gly Leu Ile Arg  Glu Phe Ser 
    2825                 2830                 2835             


Glu Gly  Val Glu Ala Phe Phe  Tyr Glu Pro Tyr Gln  Gly Ala Ile 
    2840                 2845                 2850             


Gln Gly  Pro Glu Glu Phe Val  Glu Gly Met Ala Leu  Gly Leu Lys 
    2855                 2860                 2865             


Ala Leu  Val Gly Gly Ala Val  Gly Gly Leu Ala Gly  Ala Ala Ser 
    2870                 2875                 2880             


Lys Ile  Thr Gly Ala Met Ala  Lys Gly Val Ala Ala  Met Thr Met 
    2885                 2890                 2895             


Asp Glu  Asp Tyr Gln Gln Lys  Arg Arg Glu Ala Met  Asn Lys Gln 
    2900                 2905                 2910             


Pro Ala  Gly Phe Arg Glu Gly  Ile Thr Arg Gly Gly  Lys Gly Leu 
    2915                 2920                 2925             


Val Ser  Gly Phe Val Ser Gly  Ile Thr Gly Ile Val  Thr Lys Pro 
    2930                 2935                 2940             


Ile Lys  Gly Ala Gln Lys Gly  Gly Ala Ala Gly Phe  Phe Lys Gly 
    2945                 2950                 2955             


Val Gly  Lys Gly Leu Val Gly  Ala Val Ala Arg Pro  Thr Gly Gly 
    2960                 2965                 2970             


Ile Ile  Asp Met Ala Ser Ser  Thr Phe Gln Gly Ile  Lys Arg Ala 
    2975                 2980                 2985             


Thr Glu  Thr Ser Glu Val Glu  Ser Leu Arg Pro Pro  Arg Phe Phe 
    2990                 2995                 3000             


Asn Glu  Asp Gly Val Ile Arg  Pro Tyr Arg Leu Arg  Asp Gly Thr 
    3005                 3010                 3015             


Gly Asn  Gln Met Leu Gln Val  Met Glu Asn Gly Arg  Phe Ala Lys 
    3020                 3025                 3030             


Tyr Lys  Tyr Phe Thr His Val  Met Ile Asn Lys Thr  Asp Met Leu 
    3035                 3040                 3045             


Met Ile  Thr Arg Arg Gly Val  Leu Phe Val Thr Lys  Gly Thr Phe 
    3050                 3055                 3060             


Gly Gln  Leu Thr Cys Glu Trp  Gln Tyr Ser Phe Asp  Glu Phe Thr 
    3065                 3070                 3075             


Lys Glu  Pro Phe Ile Val His  Gly Arg Arg Leu Arg  Ile Glu Ala 
    3080                 3085                 3090             


Lys Glu  Arg Val Lys Ser Val  Phe His Ala Arg Glu  Phe Gly Lys 
    3095                 3100                 3105             


Ile Ile  Asn Phe Lys Thr Pro  Glu Asp Ala Arg Trp  Ile Leu Thr 
    3110                 3115                 3120             


Lys Leu  Gln Glu Ala Arg Glu  Pro Ser Pro Ser Leu  
    3125                 3130                 3135 


<210>  18
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Phe His Gly Ile Pro Ala Thr Pro Gly Ile Gly Ala Pro Gly Asn 
1               5                   10                  15      


Lys Pro Glu Leu Tyr Glu Glu Val Lys Leu Tyr Lys Asn Ala Arg Glu 
            20                  25                  30          


Arg Glu Lys Tyr Asp Asn Met Ala Glu Leu Phe Ala Val Val Lys Thr 
        35                  40                  45              


Met Gln Ala Leu Glu Lys Ala Tyr Ile Lys Asp Cys Val Ser Pro Ser 
    50                  55                  60                  


Glu Tyr Thr Ala Ala Cys Ser Arg Leu Leu Val Gln Tyr Lys Ala Ala 
65                  70                  75                  80  


Phe Arg Gln Val Gln Gly Ser Glu Ile Ser Ser Ile Asp Glu Phe Cys 
                85                  90                  95      


Arg Lys Phe Arg Leu Asp Cys Pro Leu Ala Met Glu Arg Ile Lys Glu 
            100                 105                 110         


Asp Arg Pro Ile Thr Ile Lys Asp Asp Lys Gly Asn Leu Asn Arg Cys 
        115                 120                 125             


Ile Ala Asp Val Val Ser Leu Phe Ile Thr Val Met Asp Lys Leu Arg 
    130                 135                 140                 


Leu Glu Ile Arg Ala Met Asp Glu Ile Gln Pro Asp Leu Arg Glu Leu 
145                 150                 155                 160 


Met Glu Thr Met His Arg Met Ser His Leu Pro Pro Asp Phe Glu Gly 
                165                 170                 175     


Arg Gln Thr Val Ser Gln Trp Leu Gln Thr Leu Ser Gly Met Ser Ala 
            180                 185                 190         


Ser Asp Glu Leu Asp Asp Ser Gln Val Arg Gln Met Leu Phe Asp Leu 
        195                 200                 205             


Glu Ser Ala Tyr Asn Ala Phe Asn Arg Phe Leu His Ala 
    210                 215                 220     


<210>  19
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  19
atgtttcatg ggatcccagc cacgccgggc ataggagccc ctgggaacaa gccggagctg     60

tatgaggaag tgaagttgta caagaacgcc cgggagaggg agaagtacga caacatggca    120

gagctgtttg cggtggtgaa gacaatgcaa gccctggaga aggcctacat caaggactgt    180

gtctccccca gcgagtacac tgcagcctgc tcccggctcc tggtccaata caaagctgcc    240

ttcaggcagg tccagggctc agaaatcagc tctattgacg aattctgccg caagttccgc    300

ctggactgcc cgctggccat ggagcggatc aaggaggacc ggcccatcac catcaaggac    360

gacaagggca acctcaaccg ctgcatcgca gacgtggtct cgctcttcat cacggtcatg    420

gacaagctgc gcctggagat ccgcgccatg gatgagatcc agcccgacct gcgagagctg    480

atggagacca tgcaccgcat gagccacctc ccacccgact ttgagggccg ccagacggtc    540

agccagtggc tgcagaccct gagcggcatg tcggcgtcag atgagctgga cgactcacag    600

gtgcgtcaga tgctgttcga cctggagtca gcctacaacg ccttcaaccg cttcctgcat    660

gcctga                                                               666

