                         SEQUENCE LISTING

<110>  Pieris AG; 
       Daiichi Sankyo Co., Ltd.
 
<120>  NOVEL BINDING PROTEINS FOR PCSK9

<130>  PIE14726PCT


<150>  US 61/781,511
<151>  2013-03-14

<150>  EP13175023.4
<151>  2013-07-04


<160>  89    

<170>  PatentIn version 3.5


<210>  1
<211>  158
<212>  PRT
<213>  Human

<220>
<223>  Human tear lipocalin

<400>  1

His His Leu Leu Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr 
1               5                   10                  15      


Trp Tyr Leu Lys Ala Met Thr Val Asp Arg Glu Phe Pro Glu Met Asn 
            20                  25                  30          


Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn 
        35                  40                  45              


Leu Glu Ala Lys Val Thr Met Leu Ile Ser Gly Arg Cys Gln Glu Val 
    50                  55                  60                  


Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp 
65                  70                  75                  80  


Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His 
                85                  90                  95      


Tyr Ile Phe Tyr Cys Glu Gly Glu Leu His Gly Lys Pro Val Arg Gly 
            100                 105                 110         


Val Lys Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu 
        115                 120                 125             


Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile 
    130                 135                 140                 


Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp 
145                 150                 155             


<210>  2
<211>  152
<212>  PRT
<213>  Artificial


<220>
<223>  Mutein of human tear lipocalin

<400>  2

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Glu Phe Pro Glu Met Asn Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Leu Ile Ser Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Leu His Gly Lys Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  3
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  3

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Tyr Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  4
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin


<400>  4

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Trp Gln Cys Asp Thr Gly Leu Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Ser Tyr Ala Gly Ala Phe Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Gly Gly Trp Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  5
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  5

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp His Glu Trp Asn Gly His Tyr Tyr Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Ser Tyr Arg Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Pro Gly Gly Gln His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Ser Trp Pro Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  6
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  6

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Thr Asp Asn Ser Pro Met Phe Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Gln Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Ile Gly Gly Thr His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Ala Glu Arg Gly Arg Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  7
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  7

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asn Arg Gln Gly Asp Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  8
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  8

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Lys Gly Pro Thr Pro Leu Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Phe His Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Tyr Gly Gly Arg His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Ala Ser Val Gly Asn Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  9
<211>  152
<212>  PRT
<213>  Mutein of human tear lipocalin

<400>  9

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Thr Glu His Leu Ala Asp Trp Ala Asn Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met His Gln Pro Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Ile Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Ala Tyr Pro Gly Ser Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  10
<211>  152
<212>  PRT
<213>  Mutein of human tear lipocalin

<400>  10

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Ala Asp Met Gly Asp Trp Pro Asn Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Phe Thr Arg Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Thr Gly Gly Glu His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Thr Leu Thr Gly Arg Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  11
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  11

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Trp Arg Leu Asp Asn Glu Leu Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Arg Asn Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  12
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  12

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Leu Asp Trp Gln Cys Asp Thr Gly Leu Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Ser Tyr Ala Gly Ala Phe Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Gly Gly Trp Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  13
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  13

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Thr Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro His Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  14
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  14

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Thr Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro His Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  15
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  15

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Ile Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Gly Val Lys Val Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Met Gly Gly Ser Gln 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Pro Glu Gly Pro Tyr Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  16
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  16

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Thr Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Tyr Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  17
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  17

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Ser Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro His Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  18
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  18

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Ala Leu Glu Gly Gly Gly Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Val Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Met Gly Gly Ser His 
65                  70                  75                  80  


Gly Ala Tyr Ile Thr Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Tyr Arg Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  19
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  19

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Met Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Leu Tyr Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  20
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  20

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Val Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Ser Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Pro Glu Gly Pro Tyr Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  21
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  21

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Leu Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro His Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  22
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  22

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Asp Arg His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asn Leu Gln Gly Glu Thr Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  23
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  23

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Gly Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Gly Ser His 
65                  70                  75                  80  


Val Glu His Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Lys Gly Asn Leu Gln Gly Glu Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         



<210>  24
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  24

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Gly Ser His 
65                  70                  75                  80  


Val Glu Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asn Leu Gln Gly Glu Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         



<210>  25
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  25

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Asp Val Lys Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Asp Ser His 
65                  70                  75                  80  


Val Ser Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Leu Tyr 
                85                  90                  95      


Ser Val Gly Asn Leu Gln Gly Glu Thr Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  26
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  26

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Val Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Lys Leu Gln Gly Glu Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  27
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  27

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Gly Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Arg Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Lys Leu Gln Gly Glu Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  28
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  28

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Gly Ala Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Thr Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Lys Leu Gln Gly Glu Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  29
<211>  237
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of the light chain of antibody 31H4


<220>
<221>  SIGNAL
<222>  (1)..(20)

<400>  29

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Glu Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly 
            20                  25                  30          


Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn 
        35                  40                  45              


Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Ser Gly Asn Ser Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
                85                  90                  95      


Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser 
            100                 105                 110         


Tyr Asp Ser Ser Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         
              		


<210>  30
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Variant of mutein shown in SEQ ID NO: 22

<400>  30

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Asp Arg His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asn Leu Gln Gly Glu Thr Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  31
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Variant of mutein shown in SEQ ID NO: 13

<400>  31

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Thr Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro His Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  32
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Variant of mutein shown in SEQ ID NO: 20

<400>  32

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Val Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Ser Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Pro Glu Gly Pro Tyr Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         



<210>  33
<211>  472
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of the heavy chain of antibody 31H4


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  33

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Ser Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Asp Tyr Asp Phe Trp Ser Ala Tyr Tyr Asp Ala 
        115                 120                 125             


Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         



<210>  34
<211>  692
<212>  PRT
<213>  Artificial

<220>
<223>  Full-length human proprotein convertase subtilisin/kexin type 9 
       (PCSK9) according to SWISS PROT Data Bank Accession NO: Q8NBP7 

<400>  34

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


   

<210>  35
<211>  580
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid pTLPC26 (XbaI-HindIII)

<400>  35
tctagataac gagggcaaaa aatgaaaaag acagctatcg cgattgcagt ggctctggct       60

ggcttcgcta ccgtagcgca ggccgcctca gacgaggaga ttcaggatgt gtcagggacg      120

tggtatctga aggccatgac ggtggacagg gagttccctg agatgaatct ggaatcggtg      180

acacccatga ccctcacgac cctggaaggg ggcaacctgg aagccaaggt caccatgctg      240

ataagtggcc ggagccagga ggtgaaggcc gtcctggaga aaactgacga gccgggaaaa      300

tacacggccg acgggggcaa gcacgtggca tacatcatca ggtcgcacgt gaaggaccac      360

tacatctttt actctgaggg cgagctccac gggaagccgg tcccaggggt gtggctcgtg      420

ggcagagacc ccaagaacaa cctggaagcc ttggaggact ttgagaaagc cgcaggagcc      480

cgcggactca gcacggagag catcctcatc cccaggcaga gcgaaaccag ctctccaggg      540

agcgcttggt ctcacccgca gttcgaaaaa taataagctt                            580


<210>  36
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 3

<400>  36
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgatggg tggcagccat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtccg      300

tatcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  37
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 4

<400>  37
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gattggcaat gtgatactgg gctgtggact tctgttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atgtcttacg caggggcatt tcaggaggtg      180

aaagcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggtaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgag      300

tgtggggggt ggcctgttcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  38
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 5

<400>  38
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gaccacgaat ggaacggcca ttactatacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgtcttatc gcggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgccggg tggccaacat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggttct      300

tggccgggct atccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  39
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 6

<400>  39
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcaccg acaactctcc catgtttacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgcagtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgatagg tggcacccat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtgcc      300

gaacgcggcc gtccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  40
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 7

<400>  40
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gaccgcttta aaatcgccag ctggccccgc agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgaattggt ggggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgcaggg tggcagccat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtaat      300

cgtcagggcg atccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  41
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 8

<400>  41
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcaagg gccccacgcc cctctggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgttccatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgtacgg tggccgtcat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtgcc      300

agcgtgggca acccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  42
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 9

<400>  42
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacacggaac acttagccga ttgggcgaat agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgcaccaac cgggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgatagg tggcagccat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtgcc      300

tatccgggca gcccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  43
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 10

<400>  43
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gaccgcgcgg acatgggcga ttggcccaat agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgttcaccc gcggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgacggg tggcgaacat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtacg      300

ttaacaggcc gtccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  44
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 11

<400>  44
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gactggcgtc tcgataatga actctggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgcaggg tggcagccat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtccg      300

cgtaatggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  45
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 12

<400>  45
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgactttg       60

gattggcaat gtgatactgg gctgtggact tctgttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atgtcttacg caggggcatt tcaggaggtg      180

aaagcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggtaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgag      300

tgtggggggt ggcctgttcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  46
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 13

<400>  46
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccacgatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

catcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  47
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 14

<400>  47
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggtct tagaaaagac cgacgaaccg ggcaaataca ccgcgatggg tggcagccat      240

gtggcgtaca tcactcgtag ccatgttaaa gatcactata tcttttattc cgaaggtccg      300

catcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  48
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 15

<400>  48
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggact agcgtaacac cgatgaccct gactatactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccagggagtc      180

aaagtggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgatggg tggcagccaa      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttatcc cgaaggtccg      300

tatcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  49
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 16

<400>  49
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccacgatggg tggcagccat      240

gtggcgtaca tcattcgtag ccacgttaaa gatcactata tcttttattc cgaaggcccg      300

tatcagggcg cgccggttcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  50
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 17

<400>  50
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttttcga ggggggatgc gatttggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ctggccggag ccaggaggtg      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgccagtgg gggctctcat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtcct      300

catcaggggg ctccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  51
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 18

<400>  51
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactgcactg      120

gagggcggcg gcctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagtggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgatggg tggcagccat      240

ggggcgtaca tcactcgtag ccatgttaaa gatcactata tcttttattc cgaaggtccg      300

tatcggggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  52
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 19

<400>  52
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acatggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgatggg tggcagccat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtctg      300

tatcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  53
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 20

<400>  53
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgagccg ggcaaataca ccgtgatggg aggtagccat      240

gtggcgtcca tcattcgtag ccatgttaag gatcactata tcttttaccc cgaaggtccg      300

tatcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  54
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 21

<400>  54
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacgc cgatgaccct gactacactg      120

gagggcggta acctggaggc gaaggtcacc atgatgtatg ccggccgcag tcaggaagtc      180

aaagcggttt tagaaaagac cgacgagccg ggcaaataca ccgcaatggg tggcagccat      240

gtggcgtaca tccttcgtag ccatgttaaa gatcactata tcttttattc cgaaggtccg      300

catcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  55
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 22

<400>  55
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gaccgcttta aaatcgccag ctggccccgc agcgtaactc cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgaattggt ggggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccgcgcaggg tgaccgccat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtaat      300

cttcagggcg aaacggtccc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  56
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 23

<400>  56
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gaccgcttta aaatcgccag ctggccccgc agcgtaacac cgatgaccct gactacactg      120

gggggcggca acctggaggc gaaggtcacc atgaattggt ggggccgcag ccaggaagtc      180

aaagctgttt tagaaaagac cgacgaaccg ggcaaataca ccgcgcaggg tggtagccat      240

gtggagcata tcattcgtag ccatgttaaa gatcactata tcttttattc caaaggtaat      300

cttcagggcg aaccggtccc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  57
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 24

<400>  57
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gaccgcttta aaatcgccag ctggccccgc agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgaattggt ggggccgcag ccaggaagtc      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcgcaggg tggcagccat      240

gtggagtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtaat      300

cttcagggcg aaccggtccc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  58
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 25

<400>  58
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gaccgcttta aaatcgccag ctggccccgc agcgtaacac cgatgaccct gacaacactg      120

gagggcggca acctggaggc gaaggtcacc atgaattggt ggggccgcag ccaggatgtc      180

aaagcggttt taggaaagac cgacgaaccg ggcaaataca ccgcgcaggg tgacagccat      240

gtgtcgtaca tcattcgtag ccatgttaaa gatcactata tcctttattc cgtaggtaat      300

cttcagggcg aaacggtccc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  59
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 26

<400>  59
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacaggttta agattgcttc gtggcctagg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgaattggt ggggccggag ccaggaggtg      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgccgtggg gggctctcat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtaag      300

ttgcaggggg agccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  60
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 27

<400>  60
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacaggttta agattgggtc gtggcctagg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgaattggc ggggccggag ccaggaggtg      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgcccaggg gggctctcat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtaag      300

ctgcaggggg agccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  61
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 28

<400>  61
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacaggttta agattggtgc gtggccgagg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgaattggt ggggccggag ccaggaggtg      180

aaagcggttt tagaaaagac cgacgaaccg ggcaaataca ccgccacggg gggctctcat      240

gtggcgtaca tcattcgtag ccatgttaaa gatcactata tcttttattc cgaaggtaag      300

ttgcaggggg agccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  62
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  62

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Asp Arg His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asn Leu Gln Gly Glu Thr Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150   


<210>  63
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  63

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Val Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Gly Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         




<210>  64
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  64

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Val Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Arg Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150  




<210>  65
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  65

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Thr Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Ala Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150  




<210>  66
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  66

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Val Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Asp Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150  




<210>  67
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  67

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Met Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Val Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150  






<210>  68
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  68

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Val Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Pro Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150  




<210>  69
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  69

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Val Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Lys Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150  



<210>  70
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  70

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Thr Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Arg Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150  



<210>  71
<211>  152
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  71

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Ser Arg Gly Asp Ala Ile Trp Thr Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Met Tyr Ala Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Val Met Gly Gly Ser His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Pro Leu Gln Gly Ala Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150  


<210>  72
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 62

<400>  72
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gaccgcttta aaatcgccag ctggccccgc agcgtaactc cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgaattggt ggggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccgcgcaggg tgaccgccat      240

gtggcgtaca tcattcgtag cccggttaaa gatcactata tcttttattc cgaaggtaat      300

cttcagggcg aaacggtccc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  73
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 63
<400>  73
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccgttatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

gggcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456




<210>  74
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 64

<400>  74
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccgtgatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

cgtcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  75
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 65

<400>  75
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccgtgatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

gctcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  76
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 66

<400>  76
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccatgatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

gatcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  77
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 67

<400>  77
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccatgatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

gttcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  78
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 68

<400>  78
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccatgatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

ccgcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  79
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 69
<400>  79
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccgttatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

aagcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  80
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 70

<400>  80
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccgtgatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

aggcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  81
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 71

<400>  81
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacttcagcc gcggggacgc gatatggacg agcgtaacac cgatgaccct gactacactg      120

gagggcggca acctggaggc gaaggtcacc atgatgtatg ccggccgcag ccaggaagtc      180

aaagcggttt tagaaaggac cgacgaaccg ggcaaataca ccatgatggg tggcagccat      240

gtggcgtaca tcatccgtag ccctgtcaaa gatcactata tcttttattc cgaaggcccg      300

ctgcagggcg cgccggtgcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456



<210>  82
<211>  153
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  82

Gly Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu 
1               5                   10                  15      


Lys Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser 
            20                  25                  30          


Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala 
        35                  40                  45              


Lys Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val 
    50                  55                  60                  


Leu Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Asp Arg 
65                  70                  75                  80  


His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe 
                85                  90                  95      


Tyr Ser Glu Gly Asn Leu Gln Gly Glu Thr Val Pro Gly Val Trp Leu 
            100                 105                 110         


Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu 
        115                 120                 125             


Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro 
    130                 135                 140                 


Arg Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150             


<210>  83
<211>  203
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  83

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Asp Arg His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Pro Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asn Leu Gln Gly Glu Thr Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Gly Gly Gly Ser Leu Ala Glu Ala 
145                 150                 155                 160 


Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe 
                165                 170                 175     


Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala 
            180                 185                 190         


Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Gly 
        195                 200             


<210>  84
<211>  210
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of human tear lipocalin

<400>  84

Gly Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu 
1               5                   10                  15      


Lys Ala Met Thr Val Asp Arg Phe Lys Ile Ala Ser Trp Pro Arg Ser 
            20                  25                  30          


Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala 
        35                  40                  45              


Lys Val Thr Met Asn Trp Trp Gly Arg Ser Gln Glu Val Lys Ala Val 
    50                  55                  60                  


Leu Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gln Gly Asp Arg 
65                  70                  75                  80  


His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe 
                85                  90                  95      


Tyr Ser Glu Gly Asn Leu Gln Gly Glu Thr Val Pro Gly Val Trp Leu 
            100                 105                 110         


Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu 
        115                 120                 125             


Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro 
    130                 135                 140                 


Arg Gln Ser Glu Thr Ser Ser Pro Gly Lys Leu Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
                165                 170                 175     


Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu 
            180                 185                 190         


Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Gly Lys 
        195                 200                 205             


Leu Asn 
    210 


<210>  85
<211>  48
<212>  PRT
<213>  artificial

<220>
<223>  Albumin binding domain (ABD)

<400>  85

Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr 
1               5                   10                  15      


Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val 
            20                  25                  30          


Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Gly 
        35                  40                  45              


<210>  86
<211>  456
<212>  DNA
<213>  artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 62

<400>  86
gcaagtgatg aagaaattca ggatgttagc ggcacctggt atctgaaagc aatgaccgtt       60

gatcgcttta aaatcgcaag ctggcctcgt agcgttaccc cgatgaccct gaccaccctg      120

gaaggtggta atctggaagc aaaagttacc atgaattggt ggggtcgtag ccaagaagtt      180

aaagcagttc tggaacgtac cgatgaaccg ggtaaataca ccgcacaggg tgatcgtcat      240

gttgcatata tcattcgtag ccctgtgaaa gaccactaca tcttttatag cgaaggtaat      300

ctgcagggtg aaaccgttcc gggtgtttgg ctggttggtc gtgatccgaa aaataacctg      360

gaagcactgg aagattttga aaaagcagcc ggtgcacgtg gtctgagcac cgaaagcatt      420

ctgattccgc gtcagagcga aaccagcagt ccggga                                456


<210>  87
<211>  459
<212>  DNA
<213>  artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 82

<400>  87
ggtgcaagtg atgaagaaat tcaggatgtt agcggcacct ggtatctgaa agcaatgacc       60

gttgatcgct ttaaaatcgc aagctggcct cgtagcgtta ccccgatgac cctgaccacc      120

ctggaaggtg gtaatctgga agcaaaagtt accatgaatt ggtggggtcg tagccaagaa      180

gttaaagcag ttctggaacg taccgatgaa ccgggtaaat acaccgcaca gggtgatcgt      240

catgttgcat atatcattcg tagccatgtg aaagaccact acatctttta tagcgaaggt      300

aatctgcagg gtgaaaccgt tccgggtgtt tggctggttg gtcgtgatcc gaaaaataac      360

ctggaagcac tggaagattt tgaaaaagca gccggtgcac gtggtctgag caccgaaagc      420

attctgattc cgcgtcagag cgaaaccagc agtccggga                             459


<210>  88
<211>  609
<212>  DNA
<213>  artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 83

<400>  88
gcgagcgatg aagagatcca agacgtcagc ggcacctggt acctgaaagc aatgactgtc       60

gaccgtttta agatcgcgag ctggccgcgt agcgttacgc caatgaccct gacgaccctg      120

gagggcggca acttggaagc gaaggtgacg atgaattggt ggggtcgcag ccaagaagtg      180

aaagccgttc tggagcgcac ggacgagccg ggtaagtata ccgcgcaggg tgatcgtcat      240

gtggcatata tcattcgcag cccggtgaag gaccactaca ttttctactc tgagggtaat      300

ttgcagggtg aaaccgttcc tggcgtttgg ctggtcggtc gtgatccgaa aaacaatctg      360

gaagcactgg aggattttga gaaagctgcc ggtgcgcgtg gcctgtcgac cgagtctatt      420

ctgattccgc gccagtccga aacctccagc ccgggtggcg gtggtagcct ggcagaggcg      480

aaagaagcgg ctaacgctga gctggacagc tacggcgtga gcgatttcta taaacgtctg      540

atcgataagg ccaagaccgt cgagggtgtt gaagcgctga aagacgccat cctggcggca      600

ttgccgggt                                                              609


<210>  89
<211>  630
<212>  DNA
<213>  artificial

<220>
<223>  DNA sequence of mutein shown in SEQ ID NO: 84

<400>  89
ggtgcaagtg atgaagaaat tcaggatgtt agcggcacct ggtatctgaa agcaatgacc       60

gttgatcgct ttaaaatcgc aagctggcct cgtagcgtta ccccgatgac cctgaccacc      120

ctggaaggtg gtaatctgga agcaaaagtt accatgaatt ggtggggtcg tagccaagaa      180

gttaaagcag ttctggaacg taccgatgaa ccgggtaaat acaccgcaca gggtgatcgt      240

catgttgcat atatcattcg tagccatgtg aaagaccact acatctttta tagcgaaggt      300

aatctgcagg gtgaaaccgt tccgggtgtt tggctggttg gtcgtgatcc gaaaaataac      360

ctggaagcac tggaagattt tgaaaaagca gccggtgcac gtggtctgag caccgaaagc      420

attctgattc cgcgtcagag cgaaaccagc agtccgggta agcttggagg tggcggaagc      480

ctggcagaag caaaagaagc agcaaacgca gaactggata gctatggtgt tagcgatttc      540

tataaacgcc tgatcgataa agccaaaacc gttgaaggtg ttgaagcact gaaagatgca      600

attctggcag cactgccggg taagcttaat                                       630





