                         SEQUENCE LISTING

<110>  Emergent Product Development Germany GmbH
       Leyrer, Sonja
       Kindsmueller, Kathrin
 
<120>  RSV Vaccines

<130>  145-019P

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of a modified F protein with del 137-145 fusion peptide and includes TM and CT. (mEM85 and mEM87)

<400>  1
atggaactgc ccatcctcaa gaccaacgcc atcaccacca tcctggccgc cgtgaccctg       60

tgcttcgcca gcagccagaa catcaccgag gaattctacc agagcacctg tagcgccgtg      120

tctaagggct acctgagcgc cctgagaacc ggctggtaca ccagcgtgat caccatcgag      180

ctgagcaaca tcaaagaaaa caagtgcaac ggcaccgacg ccaaagtgaa gctgatcaag      240

caggaactgg acaagtacaa gaacgccgtg accgaactcc agctgctgat gcagagcaca      300

cctgccgcca acaaccgggc cagacgcgag ctgcctcggt tcatgaacta caccctgaac      360

aacaccaaga ataccaacgt gaccctgagc aagaagcgga agcggcggag cgccattgcc      420

agcggaatcg ccgtgtctaa ggtgctgcac ctggaaggcg aagtgaacaa gatcaagagc      480

gccctgctga gcaccaacaa ggccgtggtg tccctgagca acggcgtgtc cgtgctgacc      540

agcaaggtgc tggatctgaa gaactacatc gacaagcagc tgctgcccat cgtgaacaag      600

cagagctgct ccatcagcaa catcgagaca gtgatcgagt tccagcagaa gaacaaccgg      660

ctgctggaaa tcacccgcga gttcagcgtg aacgctggcg tcaccacacc cgtgtccacc      720

tacatgctga ccaacagcga gctgctgagc ctgatcaacg acatgcccat caccaacgac      780

cagaagaagc tgatgagcaa caacgtgcag atcgtgcggc agcagagcta cagcatcatg      840

tccatcatca aagaagaggt gctggcctac gtggtgcagc tgcctctgta cggcgtgatc      900

gacacaccct gctggaagct gcacaccagc cctctgtgca ccaccaacac caaagagggc      960

agcaacatct gcctgacccg gaccgacaga ggctggtact gcgataatgc cggcagcgtc     1020

tcattctttc cacaagccga gacatgcaag gtgcagagca accgggtgtt ctgcgacacc     1080

atgaacagcc tgaccctgcc ctccgaagtg aacctgtgca acatcgacat cttcaaccct     1140

aagtacgact gcaagatcat gacctccaag accgacgtgt ccagctccgt gatcacctcc     1200

ctgggcgcca tcgtgtcctg ctacggcaag accaagtgca ccgccagcaa caagaacaga     1260

ggcatcatca agaccttcag caacggctgc gactacgtgt ccaacaaggg agtggacacc     1320

gtgtccgtgg gcaacaccct gtactacgtg aacaaacagg aaggcaagag cctgtacgtg     1380

aagggcgagc ccatcatcaa cttctacgac cctctggtgt ttcccagcga cgagttcgac     1440

gccagcatca gccaggtcaa cgagaagatc aaccagagcc tggccttcat cagaaagagc     1500

gacgagctgc tgcacaatgt gaatgccggc aagagcacca ccaatatcat gatcaccaca     1560

atcatcatcg tgatcatcgt catcctgctg tccctgatcg ccgtgggcct gctgctgtac     1620

tgcaaggcca gatccacacc tgtgaccctg tccaaggacc agctgagcgg catcaacaat     1680

atcgccttca gctga                                                      1695


<210>  2
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a modified F protein with del 137-145 fusion peptide and includes TM and CT. (mEM85 and mEM87)

<400>  2

Met Glu Leu Pro Ile Leu Lys Thr Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Ser Ala Ile Ala Ser Gly Ile Ala 
    130                 135                 140                 


Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser 
145                 150                 155                 160 


Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val 
                165                 170                 175     


Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys 
            180                 185                 190         


Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile Ser Asn Ile 
        195                 200                 205             


Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu Ile 
    210                 215                 220                 


Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser Thr 
225                 230                 235                 240 


Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro 
                245                 250                 255     


Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile Val 
            260                 265                 270         


Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val Leu 
        275                 280                 285             


Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro Cys 
    290                 295                 300                 


Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu Gly 
305                 310                 315                 320 


Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp Asn 
                325                 330                 335     


Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val Gln 
            340                 345                 350         


Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr Leu Pro Ser 
        355                 360                 365             


Glu Val Asn Leu Cys Asn Ile Asp Ile Phe Asn Pro Lys Tyr Asp Cys 
    370                 375                 380                 


Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr Ser 
385                 390                 395                 400 


Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala Ser 
                405                 410                 415     


Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp Tyr 
            420                 425                 430         


Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu Tyr 
        435                 440                 445             


Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu Pro 
    450                 455                 460                 


Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp 
465                 470                 475                 480 


Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe 
                485                 490                 495     


Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser 
            500                 505                 510         


Thr Thr Asn Ile Met Ile Thr Thr Ile Ile Ile Val Ile Ile Val Ile 
        515                 520                 525             


Leu Leu Ser Leu Ile Ala Val Gly Leu Leu Leu Tyr Cys Lys Ala Arg 
    530                 535                 540                 


Ser Thr Pro Val Thr Leu Ser Lys Asp Gln Leu Ser Gly Ile Asn Asn 
545                 550                 555                 560 


Ile Ala Phe Ser 
                


<210>  3
<211>  1548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of a modified F protein with del 137-145 fusion peptide and no TM-CT (mEM86 and mEM88)

<400>  3
atggaactgc ccatcctcaa gaccaacgcc atcaccacca tcctggccgc cgtgaccctg       60

tgcttcgcca gcagccagaa catcaccgag gaattctacc agagcacctg tagcgccgtg      120

tctaagggct acctgagcgc cctgagaacc ggctggtaca ccagcgtgat caccatcgag      180

ctgagcaaca tcaaagaaaa caagtgcaac ggcaccgacg ccaaagtgaa gctgatcaag      240

caggaactgg acaagtacaa gaacgccgtg accgaactcc agctgctgat gcagagcaca      300

cctgccgcca acaaccgggc cagacgcgag ctgcctcggt tcatgaacta caccctgaac      360

aacaccaaga ataccaacgt gaccctgagc aagaagcgga agcggcggag cgccattgcc      420

agcggaatcg ccgtgtctaa ggtgctgcac ctggaaggcg aagtgaacaa gatcaagagc      480

gccctgctga gcaccaacaa ggccgtggtg tccctgagca acggcgtgtc cgtgctgacc      540

agcaaggtgc tggatctgaa gaactacatc gacaagcagc tgctgcccat cgtgaacaag      600

cagagctgct ccatcagcaa catcgagaca gtgatcgagt tccagcagaa gaacaaccgg      660

ctgctggaaa tcacccgcga gttcagcgtg aacgctggcg tcaccacacc cgtgtccacc      720

tacatgctga ccaacagcga gctgctgagc ctgatcaacg acatgcccat caccaacgac      780

cagaagaagc tgatgagcaa caacgtgcag atcgtgcggc agcagagcta cagcatcatg      840

tccatcatca aagaagaggt gctggcctac gtggtgcagc tgcctctgta cggcgtgatc      900

gacacaccct gctggaagct gcacaccagc cctctgtgca ccaccaacac caaagagggc      960

agcaacatct gcctgacccg gaccgacaga ggctggtact gcgataatgc cggcagcgtc     1020

tcattctttc cacaagccga gacatgcaag gtgcagagca accgggtgtt ctgcgacacc     1080

atgaacagcc tgaccctgcc ctccgaagtg aacctgtgca acatcgacat cttcaaccct     1140

aagtacgact gcaagatcat gacctccaag accgacgtgt ccagctccgt gatcacctcc     1200

ctgggcgcca tcgtgtcctg ctacggcaag accaagtgca ccgccagcaa caagaacaga     1260

ggcatcatca agaccttcag caacggctgc gactacgtgt ccaacaaggg agtggacacc     1320

gtgtccgtgg gcaacaccct gtactacgtg aacaaacagg aaggcaagag cctgtacgtg     1380

aagggcgagc ccatcatcaa cttctacgac cctctggtgt ttcccagcga cgagttcgac     1440

gccagcatca gccaggtcaa cgagaagatc aaccagagcc tggccttcat cagaaagagc     1500

gacgagctgc tgcacaatgt gaatgccggc aagagcacca ccaattga                  1548


<210>  4
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a modified F protein with del 137-145 fusion peptide and no TM-CT (mEM86 and mEM88)

<400>  4

Met Glu Leu Pro Ile Leu Lys Thr Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Ser Ala Ile Ala Ser Gly Ile Ala 
    130                 135                 140                 


Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser 
145                 150                 155                 160 


Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val 
                165                 170                 175     


Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys 
            180                 185                 190         


Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile Ser Asn Ile 
        195                 200                 205             


Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu Ile 
    210                 215                 220                 


Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser Thr 
225                 230                 235                 240 


Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro 
                245                 250                 255     


Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile Val 
            260                 265                 270         


Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val Leu 
        275                 280                 285             


Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro Cys 
    290                 295                 300                 


Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu Gly 
305                 310                 315                 320 


Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp Asn 
                325                 330                 335     


Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val Gln 
            340                 345                 350         


Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr Leu Pro Ser 
        355                 360                 365             


Glu Val Asn Leu Cys Asn Ile Asp Ile Phe Asn Pro Lys Tyr Asp Cys 
    370                 375                 380                 


Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr Ser 
385                 390                 395                 400 


Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala Ser 
                405                 410                 415     


Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp Tyr 
            420                 425                 430         


Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu Tyr 
        435                 440                 445             


Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu Pro 
    450                 455                 460                 


Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp 
465                 470                 475                 480 


Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe 
                485                 490                 495     


Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser 
            500                 505                 510         


Thr Thr Asn 
        515 


<210>  5
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of a conserved RSV attachment G-protein (RAGP) w/N-Met (mEM64, mEM66, mEM87 and mEM88)

<400>  5
atgaccgtca agaccaagaa caccaccacc acccagaccc agcccagcaa gcccaccacc       60

aagcagcggc agaacaagcc tcccaacaag cccaacaacg acttccactt cgaggtgttc      120

aacttcgtgc cctgctccat ctgctccaac aaccctacct gctgggccat ctgcaagcgg      180

atccctaaca agaagcccgg caagaaaaca accaccaagc ctaccaagaa gcccaccttc      240

aagaccacca agaaggacca caagcctcag accacaaagc ccaaagaggt gcccaccact      300

aagccctga                                                              309


<210>  6
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a conserved RSV attachment G-protein (RAGP) w/N-Met (mEM64, mEM66, mEM87 and mEM88)

<400>  6

Met Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser 
1               5                   10                  15      


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn 
            20                  25                  30          


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
        35                  40                  45              


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
    50                  55                  60                  


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe 
65                  70                  75                  80  


Lys Thr Thr Lys Lys Asp His Lys Pro Gln Thr Thr Lys Pro Lys Glu 
                85                  90                  95      


Val Pro Thr Thr Lys Pro 
            100         


<210>  7
<211>  95
<212>  DNA
<213>  Vaccinia virus

<400>  7
cccataaata ataaatacaa taattaattt ctcgtaaaag tagaaaatat attctaattt       60

attgcatggt aaggaagtag aatcataaag aacag                                  95


<210>  8
<211>  70
<212>  DNA
<213>  Vaccinia virus

<400>  8
aaaaaatgaa aataaataca aaggttcttg agggttgtgt taaattgaaa gcgagaaata       60

atcataaatt                                                              70


<210>  9
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fwd primer

<400>  9
aagcggcgga gcgccattgc cagcggaatc gccgtgtcta ag                          42


<210>  10
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rev primer

<400>  10
aatggcgctc cgccgcttcc gcttcttgct cagggtcacg                             40


<210>  11
<211>  573
<212>  PRT
<213>  respiratory syncytial virus


<220>
<221>  SIGNAL
<222>  (1)..(22)
<223>  Signal sequence

<220>
<221>  mat_peptide
<222>  (23)..(573)
<223>  mature protein

<220>
<221>  MISC_FEATURE
<222>  (106)..(109)
<223>  furin cleavage site

<220>
<221>  MISC_FEATURE
<222>  (133)..(136)
<223>  furin cleavage site

<220>
<221>  MISC_FEATURE
<222>  (137)..(155)
<223>  fusion peptide domain

<220>
<221>  MISC_FEATURE
<222>  (525)..(573)
<223>  transmembrane and cytoplasmic domain

<400>  11

Met Glu Leu Pro Ile Leu Lys Thr Asn Ala Ile Thr Thr Ile Leu Ala 
        -20                 -15                 -10             


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
    -5              -1  1               5                   10  


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
                15                  20                  25      


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
            30                  35                  40          


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
        45                  50                  55              


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
    60                  65                  70                  


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
75                  80                  85                  90  


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
                95                  100                 105     


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
            110                 115                 120         


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
        125                 130                 135             


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
    140                 145                 150                 


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
155                 160                 165                 170 


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
                175                 180                 185     


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
            190                 195                 200         


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
        205                 210                 215             


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
    220                 225                 230                 


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
235                 240                 245                 250 


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
                255                 260                 265     


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
            270                 275                 280         


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
        285                 290                 295             


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
    300                 305                 310                 


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
315                 320                 325                 330 


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
                335                 340                 345     


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Ile 
            350                 355                 360         


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
        365                 370                 375             


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
    380                 385                 390                 


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
395                 400                 405                 410 


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
                415                 420                 425     


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
            430                 435                 440         


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
        445                 450                 455             


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
    460                 465                 470                 


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
475                 480                 485                 490 


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
                495                 500                 505     


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
            510                 515                 520         


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
        525                 530                 535             


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser 
    540                 545                 550     


<210>  12
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of an RSV F protein (mEM60)

<400>  12
atggaactgc ccatcctcaa gaccaacgcc atcaccacca tcctggccgc cgtgaccctg       60

tgcttcgcca gcagccagaa catcaccgag gaattctacc agagcacctg tagcgccgtg      120

tctaagggct acctgagcgc cctgagaacc ggctggtaca ccagcgtgat caccatcgag      180

ctgagcaaca tcaaagaaaa caagtgcaac ggcaccgacg ccaaagtgaa gctgatcaag      240

caggaactgg acaagtacaa gaacgccgtg accgaactcc agctgctgat gcagagcaca      300

cctgccgcca acaaccgggc cagacgcgag ctgcctcggt tcatgaacta caccctgaac      360

aacaccaaga ataccaacgt gaccctgagc aagaagcgga agcggcggtt cctgggcttc      420

ctgctgggcg tgggcagcgc cattgccagc ggaatcgccg tgtctaaggt gctgcacctg      480

gaaggcgaag tgaacaagat caagagcgcc ctgctgagca ccaacaaggc cgtggtgtcc      540

ctgagcaacg gcgtgtccgt gctgaccagc aaggtgctgg atctgaagaa ctacatcgac      600

aagcagctgc tgcccatcgt gaacaagcag agctgctcca tcagcaacat cgagacagtg      660

atcgagttcc agcagaagaa caaccggctg ctggaaatca cccgcgagtt cagcgtgaac      720

gctggcgtca ccacacccgt gtccacctac atgctgacca acagcgagct gctgagcctg      780

atcaacgaca tgcccatcac caacgaccag aagaagctga tgagcaacaa cgtgcagatc      840

gtgcggcagc agagctacag catcatgtcc atcatcaaag aagaggtgct ggcctacgtg      900

gtgcagctgc ctctgtacgg cgtgatcgac acaccctgct ggaagctgca caccagccct      960

ctgtgcacca ccaacaccaa agagggcagc aacatctgcc tgacccggac cgacagaggc     1020

tggtactgcg ataatgccgg cagcgtctca ttctttccac aagccgagac atgcaaggtg     1080

cagagcaacc gggtgttctg cgacaccatg aacagcctga ccctgccctc cgaagtgaac     1140

ctgtgcaaca tcgacatctt caaccctaag tacgactgca agatcatgac ctccaagacc     1200

gacgtgtcca gctccgtgat cacctccctg ggcgccatcg tgtcctgcta cggcaagacc     1260

aagtgcaccg ccagcaacaa gaacagaggc atcatcaaga ccttcagcaa cggctgcgac     1320

tacgtgtcca acaagggagt ggacaccgtg tccgtgggca acaccctgta ctacgtgaac     1380

aaacaggaag gcaagagcct gtacgtgaag ggcgagccca tcatcaactt ctacgaccct     1440

ctggtgtttc ccagcgacga gttcgacgcc agcatcagcc aggtcaacga gaagatcaac     1500

cagagcctgg ccttcatcag aaagagcgac gagctgctgc acaatgtgaa tgccggcaag     1560

agcaccacca atatcatgat caccacaatc atcatcgtga tcatcgtcat cctgctgtcc     1620

ctgatcgccg tgggcctgct gctgtactgc aaggccagat ccacacctgt gaccctgtcc     1680

aaggaccagc tgagcggcat caacaatatc gccttcagct ga                        1722


<210>  13
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of an RSV F protein (mEM60)

<400>  13

Met Glu Leu Pro Ile Leu Lys Thr Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Ile 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser 
                565                 570             


<210>  14
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of a modified F protein with deletion of the TM and CT (mEM61)

<400>  14
atggaactgc ccatcctcaa gaccaacgcc atcaccacca tcctggccgc cgtgaccctg       60

tgcttcgcca gcagccagaa catcaccgag gaattctacc agagcacctg tagcgccgtg      120

tctaagggct acctgagcgc cctgagaacc ggctggtaca ccagcgtgat caccatcgag      180

ctgagcaaca tcaaagaaaa caagtgcaac ggcaccgacg ccaaagtgaa gctgatcaag      240

caggaactgg acaagtacaa gaacgccgtg accgaactcc agctgctgat gcagagcaca      300

cctgccgcca acaaccgggc cagacgcgag ctgcctcggt tcatgaacta caccctgaac      360

aacaccaaga ataccaacgt gaccctgagc aagaagcgga agcggcggtt cctgggcttc      420

ctgctgggcg tgggcagcgc cattgccagc ggaatcgccg tgtctaaggt gctgcacctg      480

gaaggcgaag tgaacaagat caagagcgcc ctgctgagca ccaacaaggc cgtggtgtcc      540

ctgagcaacg gcgtgtccgt gctgaccagc aaggtgctgg atctgaagaa ctacatcgac      600

aagcagctgc tgcccatcgt gaacaagcag agctgctcca tcagcaacat cgagacagtg      660

atcgagttcc agcagaagaa caaccggctg ctggaaatca cccgcgagtt cagcgtgaac      720

gctggcgtca ccacacccgt gtccacctac atgctgacca acagcgagct gctgagcctg      780

atcaacgaca tgcccatcac caacgaccag aagaagctga tgagcaacaa cgtgcagatc      840

gtgcggcagc agagctacag catcatgtcc atcatcaaag aagaggtgct ggcctacgtg      900

gtgcagctgc ctctgtacgg cgtgatcgac acaccctgct ggaagctgca caccagccct      960

ctgtgcacca ccaacaccaa agagggcagc aacatctgcc tgacccggac cgacagaggc     1020

tggtactgcg ataatgccgg cagcgtctca ttctttccac aagccgagac atgcaaggtg     1080

cagagcaacc gggtgttctg cgacaccatg aacagcctga ccctgccctc cgaagtgaac     1140

ctgtgcaaca tcgacatctt caaccctaag tacgactgca agatcatgac ctccaagacc     1200

gacgtgtcca gctccgtgat cacctccctg ggcgccatcg tgtcctgcta cggcaagacc     1260

aagtgcaccg ccagcaacaa gaacagaggc atcatcaaga ccttcagcaa cggctgcgac     1320

tacgtgtcca acaagggagt ggacaccgtg tccgtgggca acaccctgta ctacgtgaac     1380

aaacaggaag gcaagagcct gtacgtgaag ggcgagccca tcatcaactt ctacgaccct     1440

ctggtgtttc ccagcgacga gttcgacgcc agcatcagcc aggtcaacga gaagatcaac     1500

cagagcctgg ccttcatcag aaagagcgac gagctgctgc acaatgtgaa tgccggcaag     1560

agcaccacca attga                                                      1575


<210>  15
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a modified F protein with deletion of the TM and CT (mEM61)

<400>  15

Met Glu Leu Pro Ile Leu Lys Thr Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Ile 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn 
        515                 520                 


<210>  16
<211>  1665
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of a modified F protein with deletion of the fusion peptide (mEM62, mEM65 & mEM66)

<400>  16
atggaactgc ccatcctcaa gaccaacgcc atcaccacca tcctggccgc cgtgaccctg       60

tgcttcgcca gcagccagaa catcaccgag gaattctacc agagcacctg tagcgccgtg      120

tctaagggct acctgagcgc cctgagaacc ggctggtaca ccagcgtgat caccatcgag      180

ctgagcaaca tcaaagaaaa caagtgcaac ggcaccgacg ccaaagtgaa gctgatcaag      240

caggaactgg acaagtacaa gaacgccgtg accgaactcc agctgctgat gcagagcaca      300

cctgccgcca acaaccgggc cagacgcgag ctgcctcggt tcatgaacta caccctgaac      360

aacaccaaga ataccaacgt gaccctgagc aagaagcgga agcggcggaa ggtgctgcac      420

ctggaaggcg aagtgaacaa gatcaagagc gccctgctga gcaccaacaa ggccgtggtg      480

tccctgagca acggcgtgtc cgtgctgacc agcaaggtgc tggatctgaa gaactacatc      540

gacaagcagc tgctgcccat cgtgaacaag cagagctgct ccatcagcaa catcgagaca      600

gtgatcgagt tccagcagaa gaacaaccgg ctgctggaaa tcacccgcga gttcagcgtg      660

aacgctggcg tcaccacacc cgtgtccacc tacatgctga ccaacagcga gctgctgagc      720

ctgatcaacg acatgcccat caccaacgac cagaagaagc tgatgagcaa caacgtgcag      780

atcgtgcggc agcagagcta cagcatcatg tccatcatca aagaagaggt gctggcctac      840

gtggtgcagc tgcctctgta cggcgtgatc gacacaccct gctggaagct gcacaccagc      900

cctctgtgca ccaccaacac caaagagggc agcaacatct gcctgacccg gaccgacaga      960

ggctggtact gcgataatgc cggcagcgtc tcattctttc cacaagccga gacatgcaag     1020

gtgcagagca accgggtgtt ctgcgacacc atgaacagcc tgaccctgcc ctccgaagtg     1080

aacctgtgca acatcgacat cttcaaccct aagtacgact gcaagatcat gacctccaag     1140

accgacgtgt ccagctccgt gatcacctcc ctgggcgcca tcgtgtcctg ctacggcaag     1200

accaagtgca ccgccagcaa caagaacaga ggcatcatca agaccttcag caacggctgc     1260

gactacgtgt ccaacaaggg agtggacacc gtgtccgtgg gcaacaccct gtactacgtg     1320

aacaaacagg aaggcaagag cctgtacgtg aagggcgagc ccatcatcaa cttctacgac     1380

cctctggtgt ttcccagcga cgagttcgac gccagcatca gccaggtcaa cgagaagatc     1440

aaccagagcc tggccttcat cagaaagagc gacgagctgc tgcacaatgt gaatgccggc     1500

aagagcacca ccaatatcat gatcaccaca atcatcatcg tgatcatcgt catcctgctg     1560

tccctgatcg ccgtgggcct gctgctgtac tgcaaggcca gatccacacc tgtgaccctg     1620

tccaaggacc agctgagcgg catcaacaat atcgccttca gctga                     1665


<210>  17
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a modified F protein with deletion of the fusion peptide (mEM62, mEM65 & mEM66)

<400>  17

Met Glu Leu Pro Ile Leu Lys Thr Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Lys Val Leu His Leu Glu Gly Glu 
    130                 135                 140                 


Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val 
145                 150                 155                 160 


Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu 
                165                 170                 175     


Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser 
            180                 185                 190         


Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn 
        195                 200                 205             


Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val 
    210                 215                 220                 


Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser 
225                 230                 235                 240 


Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser 
                245                 250                 255     


Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile 
            260                 265                 270         


Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly 
        275                 280                 285             


Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr 
    290                 295                 300                 


Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg 
305                 310                 315                 320 


Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala 
                325                 330                 335     


Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn 
            340                 345                 350         


Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Ile Asp Ile Phe 
        355                 360                 365             


Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser 
    370                 375                 380                 


Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys 
385                 390                 395                 400 


Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe 
                405                 410                 415     


Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser 
            420                 425                 430         


Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu 
        435                 440                 445             


Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe 
    450                 455                 460                 


Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile 
465                 470                 475                 480 


Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn 
                485                 490                 495     


Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr Thr Ile Ile 
            500                 505                 510         


Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val Gly Leu Leu 
        515                 520                 525             


Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln 
    530                 535                 540                 


Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser 
545                 550                 


<210>  18
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of a modified F protein with deletion of the fusion peptide region and deletion of the TM and CT (mEM63, mEM64 & mEM67)

<400>  18
atggaactgc ccatcctcaa gaccaacgcc atcaccacca tcctggccgc cgtgaccctg       60

tgcttcgcca gcagccagaa catcaccgag gaattctacc agagcacctg tagcgccgtg      120

tctaagggct acctgagcgc cctgagaacc ggctggtaca ccagcgtgat caccatcgag      180

ctgagcaaca tcaaagaaaa caagtgcaac ggcaccgacg ccaaagtgaa gctgatcaag      240

caggaactgg acaagtacaa gaacgccgtg accgaactcc agctgctgat gcagagcaca      300

cctgccgcca acaaccgggc cagacgcgag ctgcctcggt tcatgaacta caccctgaac      360

aacaccaaga ataccaacgt gaccctgagc aagaagcgga agcggcggaa ggtgctgcac      420

ctggaaggcg aagtgaacaa gatcaagagc gccctgctga gcaccaacaa ggccgtggtg      480

tccctgagca acggcgtgtc cgtgctgacc agcaaggtgc tggatctgaa gaactacatc      540

gacaagcagc tgctgcccat cgtgaacaag cagagctgct ccatcagcaa catcgagaca      600

gtgatcgagt tccagcagaa gaacaaccgg ctgctggaaa tcacccgcga gttcagcgtg      660

aacgctggcg tcaccacacc cgtgtccacc tacatgctga ccaacagcga gctgctgagc      720

ctgatcaacg acatgcccat caccaacgac cagaagaagc tgatgagcaa caacgtgcag      780

atcgtgcggc agcagagcta cagcatcatg tccatcatca aagaagaggt gctggcctac      840

gtggtgcagc tgcctctgta cggcgtgatc gacacaccct gctggaagct gcacaccagc      900

cctctgtgca ccaccaacac caaagagggc agcaacatct gcctgacccg gaccgacaga      960

ggctggtact gcgataatgc cggcagcgtc tcattctttc cacaagccga gacatgcaag     1020

gtgcagagca accgggtgtt ctgcgacacc atgaacagcc tgaccctgcc ctccgaagtg     1080

aacctgtgca acatcgacat cttcaaccct aagtacgact gcaagatcat gacctccaag     1140

accgacgtgt ccagctccgt gatcacctcc ctgggcgcca tcgtgtcctg ctacggcaag     1200

accaagtgca ccgccagcaa caagaacaga ggcatcatca agaccttcag caacggctgc     1260

gactacgtgt ccaacaaggg agtggacacc gtgtccgtgg gcaacaccct gtactacgtg     1320

aacaaacagg aaggcaagag cctgtacgtg aagggcgagc ccatcatcaa cttctacgac     1380

cctctggtgt ttcccagcga cgagttcgac gccagcatca gccaggtcaa cgagaagatc     1440

aaccagagcc tggccttcat cagaaagagc gacgagctgc tgcacaatgt gaatgccggc     1500

aagagcacca ccaattga                                                   1518


<210>  19
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino sequence of a modified F protein with deletion of the fusion peptide region and deletion of the TM and CT (mEM63, mEM64 & mEM67)

<400>  19

Met Glu Leu Pro Ile Leu Lys Thr Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Lys Val Leu His Leu Glu Gly Glu 
    130                 135                 140                 


Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val 
145                 150                 155                 160 


Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu 
                165                 170                 175     


Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser 
            180                 185                 190         


Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn 
        195                 200                 205             


Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val 
    210                 215                 220                 


Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser 
225                 230                 235                 240 


Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser 
                245                 250                 255     


Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile 
            260                 265                 270         


Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly 
        275                 280                 285             


Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr 
    290                 295                 300                 


Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg 
305                 310                 315                 320 


Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala 
                325                 330                 335     


Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn 
            340                 345                 350         


Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Ile Asp Ile Phe 
        355                 360                 365             


Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser 
    370                 375                 380                 


Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys 
385                 390                 395                 400 


Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe 
                405                 410                 415     


Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser 
            420                 425                 430         


Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu 
        435                 440                 445             


Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe 
    450                 455                 460                 


Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile 
465                 470                 475                 480 


Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn 
                485                 490                 495     


Val Asn Ala Gly Lys Ser Thr Thr Asn 
            500                 505 


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A Sequence

<400>  20

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A Sequence

<400>  21

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A Sequence

<400>  22

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A Sequence

<400>  23

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A Sequence

<400>  24

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  25
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A Sequence

<400>  25

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  26
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A Sequence

<400>  26

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu 
        35                  40                  45              


Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
    50                  55              


<210>  27
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A Sequence

<400>  27

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  28
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A Sequence

<400>  28

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus furin cleavage site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Can be lysine or arginine

<400>  29

Arg Xaa Xaa Arg 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Ala Lys Arg 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  31

Ile Glu Gly Arg 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  32

Ile Asp Gly Arg 
1               


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Leu Ala Gly Phe Ala Thr Val Ala Gln Ala 
1               5                   10  


<210>  34
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  34

Leu Val Pro Arg Gly Ser 
1               5       


