                         SEQUENCE LISTING

<110>  GlaxoSmithKline Intellectual Property Development Limited
 
<120>  Antigen Binding Proteins

<130>  PB65397P

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  H5L7, CDRL1 (Kabat defined)

<400>  1

Lys Ser Ser Gln Ser Leu Leu Asn Pro Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  2
<211>  7
<212>  PRT
<213>  Murine

<400>  2

Phe Ala Ser Thr Arg Asp Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Murine

<400>  3

Leu Gln His Phe Gly Thr Pro Pro Thr 
1               5                   


<210>  4
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  H5L7, VL

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  5
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H5L7, light chain humanised construct

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  6
<211>  5
<212>  PRT
<213>  Murine

<400>  6

Ala Tyr Gly Val Asn 
1               5   


<210>  7
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  H5L7, CDRH2 (Kabat defined)

<400>  7

Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  8
<211>  8
<212>  PRT
<213>  Murine

<400>  8

Glu Gly Asp Val Ala Phe Asp Tyr 
1               5               


<210>  9
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  H5L7, VH

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H5L7, heavy chain humanised construct

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  11
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H1L7, light chain humanised construct

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  12
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H1L7, heavy chain humanised construct

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  13
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  J7L7, light chain humanised construct

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  14
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  J7L7, heavy chain humanised construct

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  15
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H4L7, light chain humanised construct

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  16
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H4L7, heavy chain humanised construct

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  17
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  J11L7, light chain humanised construct

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  18
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  J11L7, heavy chain humanised construct

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  19
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H2L7, light chain humanised construct

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  20
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H2L7, heavy chain humanised construct

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  21
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  J13L7, light chain humanised construct

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  22
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  J13L7, heavy chain humanised construct

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  23
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H7L7, light chain humanised construct

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  24
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H7L7, heavy chain humanised construct

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  25
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  J0L7, light chain humanised construct

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  26
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  J0L7, heavy chain humanised construct

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  27
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H0L7, light chain humanised construct

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Pro 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  28
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H0L7, heavy chain humanised construct

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  29
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H1L1, light chain humanised construct

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  30
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H1L1, heavy chain humanised construct

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  31
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H5L1, light chain humanised construct

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  32
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H5L1, heavy chain humanised construct

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  33
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  J7L1, light chain humanised construct

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  34
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  J7L1, heavy chain humanised construct

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  35
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  J11L1, light chain humanised construct

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  36
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  J11L1, heavy chain humanised construct

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  37
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  J13L1, light chain humanised construct

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  38
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  J13L1, heavy chain humanised construct

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  39
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H7L1, light chain humanised construct

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  40
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H7L1, heavy chain humanised construct

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asp Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  41
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  J0L1, light chain humanised construct

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  42
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  J0L1, heavy chain humanised construct

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  43
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  H0L1, light chain humanised construct

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  44
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  H0L1, heavy chain humanised construct

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  45
<211>  106
<212>  PRT
<213>  Human

<400>  45

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  46
<211>  330
<212>  PRT
<213>  Human

<400>  46

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  47
<211>  116
<212>  PRT
<213>  Murine

<400>  47

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  48
<211>  114
<212>  PRT
<213>  Murine

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  49
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  IMP731, heavy chain sequence

<400>  49

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ala Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Asp Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  50
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  IMP731, light chain sequence

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln 
                85                  90                  95      


His Phe Gly Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  51
<211>  417
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant human LAG-3-ECD-His6

<400>  51

Leu Gln Pro Gly Ala Glu Val Pro Val Val Trp Ala Gln Glu Gly Ala 
1               5                   10                  15      


Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser 
            20                  25                  30          


Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln Pro Asp Ser Gly 
        35                  40                  45              


Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro Gly Pro His Pro 
    50                  55                  60                  


Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu 
65                  70                  75                  80  


Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro 
                85                  90                  95      


Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu 
            100                 105                 110         


Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala 
        115                 120                 125             


Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu 
    130                 135                 140                 


Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser 
145                 150                 155                 160 


Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala 
                165                 170                 175     


Ser Val His Trp Phe Arg Asn Arg Gly Gln Gly Arg Val Pro Val Arg 
            180                 185                 190         


Glu Ser Pro His His His Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln 
        195                 200                 205             


Val Ser Pro Met Asp Ser Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg 
    210                 215                 220                 


Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu Thr Val Leu Gly Leu 
225                 230                 235                 240 


Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala Gly Ala Gly Ser Arg Val 
                245                 250                 255     


Gly Leu Pro Cys Arg Leu Pro Ala Gly Val Gly Thr Arg Ser Phe Leu 
            260                 265                 270         


Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Asp Leu Leu Val Thr 
        275                 280                 285             


Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu Asp Val Ser Gln Ala 
    290                 295                 300                 


Gln Ala Gly Thr Tyr Thr Cys His Ile His Leu Gln Glu Gln Gln Leu 
305                 310                 315                 320 


Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val Thr Pro Lys Ser Phe 
                325                 330                 335     


Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys Glu Val Thr Pro Val 
            340                 345                 350         


Ser Gly Gln Glu Arg Phe Val Trp Ser Ser Leu Asp Thr Pro Ser Gln 
        355                 360                 365             


Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu 
    370                 375                 380                 


Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly 
385                 390                 395                 400 


Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro His His His His His 
                405                 410                 415     


His 
    


<210>  52
<211>  417
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant cynomolgus macaque LAG-3 ECD-His6

<400>  52

Pro Gln Pro Gly Ala Glu Ile Ser Val Val Trp Ala Gln Glu Gly Ala 
1               5                   10                  15      


Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser 
            20                  25                  30          


Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln Pro Asp Ser Gly 
        35                  40                  45              


Pro Pro Ala Pro Ala Pro Gly His Pro Pro Ala Pro Gly His Arg Pro 
    50                  55                  60                  


Ala Ala Pro Tyr Ser Trp Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu 
65                  70                  75                  80  


Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro 
                85                  90                  95      


Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu 
            100                 105                 110         


Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu Tyr Arg Ala Thr 
        115                 120                 125             


Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu Arg Leu Arg Val 
    130                 135                 140                 


Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly Ser Leu Arg Thr Ser 
145                 150                 155                 160 


Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala 
                165                 170                 175     


Ser Val His Trp Phe Arg Ser Arg Gly Gln Gly Arg Val Pro Val Gln 
            180                 185                 190         


Gly Ser Pro His His His Leu Ala Glu Ser Phe Leu Phe Leu Pro His 
        195                 200                 205             


Val Gly Pro Met Asp Ser Gly Leu Trp Gly Cys Ile Leu Thr Tyr Arg 
    210                 215                 220                 


Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu Thr Val Leu Gly Leu 
225                 230                 235                 240 


Glu Pro Ala Thr Pro Leu Thr Val Tyr Ala Gly Ala Gly Ser Arg Val 
                245                 250                 255     


Glu Leu Pro Cys Arg Leu Pro Pro Ala Val Gly Thr Gln Ser Phe Leu 
            260                 265                 270         


Thr Ala Lys Trp Ala Pro Pro Gly Gly Gly Pro Asp Leu Leu Val Ala 
        275                 280                 285             


Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu Asp Val Ser Gln Ala 
    290                 295                 300                 


Gln Ala Gly Thr Tyr Ile Cys His Ile Arg Leu Gln Gly Gln Gln Leu 
305                 310                 315                 320 


Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val Thr Pro Lys Ser Phe 
                325                 330                 335     


Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys Glu Val Thr Pro Ala 
            340                 345                 350         


Ser Gly Gln Glu His Phe Val Trp Ser Pro Leu Asn Thr Pro Ser Gln 
        355                 360                 365             


Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu 
    370                 375                 380                 


Ser Gln Pro Trp Gln Cys Gln Leu His Gln Gly Glu Arg Leu Leu Gly 
385                 390                 395                 400 


Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro His His His His His 
                405                 410                 415     


His 
    


<210>  53
<211>  417
<212>  PRT
<213>  Artificial

<220>
<223>  Recombinant baboon LAG-3 ECD-His6

<400>  53

Pro Gln Pro Gly Ala Glu Ile Ser Val Val Trp Ala Gln Glu Gly Ala 
1               5                   10                  15      


Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser 
            20                  25                  30          


Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln Pro Asp Ser Gly 
        35                  40                  45              


Pro Pro Ala Pro Ala Pro Gly His Pro Pro Ala Pro Gly His Arg Pro 
    50                  55                  60                  


Ala Ala Pro Tyr Ser Trp Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu 
65                  70                  75                  80  


Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro 
                85                  90                  95      


Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu 
            100                 105                 110         


Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu Tyr Arg Ala Thr 
        115                 120                 125             


Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu Arg Leu Arg Val 
    130                 135                 140                 


Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly Ser Leu Arg Thr Ser 
145                 150                 155                 160 


Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala 
                165                 170                 175     


Ser Val His Trp Phe Arg Ser Arg Gly Gln Gly Gln Val Pro Val Gln 
            180                 185                 190         


Glu Ser Pro His His His Leu Ala Glu Ser Phe Leu Phe Leu Pro His 
        195                 200                 205             


Val Gly Pro Met Asp Ser Gly Leu Trp Gly Cys Ile Leu Thr Tyr Arg 
    210                 215                 220                 


Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu Thr Val Leu Gly Leu 
225                 230                 235                 240 


Glu Pro Thr Thr Pro Leu Thr Val Tyr Ala Gly Ala Gly Ser Arg Val 
                245                 250                 255     


Glu Leu Pro Cys Arg Leu Pro Pro Ala Val Gly Thr Gln Ser Phe Leu 
            260                 265                 270         


Thr Ala Lys Trp Ala Pro Pro Gly Gly Gly Pro Asp Leu Leu Val Val 
        275                 280                 285             


Gly Asp Asn Gly Asn Phe Thr Leu Arg Leu Glu Asp Val Ser Gln Ala 
    290                 295                 300                 


Gln Ala Gly Thr Tyr Ile Cys His Ile Arg Leu Gln Gly Gln Gln Leu 
305                 310                 315                 320 


Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val Thr Pro Lys Ser Phe 
                325                 330                 335     


Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys Glu Val Thr Pro Ala 
            340                 345                 350         


Ser Gly Gln Glu Arg Phe Val Trp Ser Pro Leu Asn Thr Pro Ser Gln 
        355                 360                 365             


Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu 
    370                 375                 380                 


Ser Gln Pro Trp Gln Cys Gln Leu His Gln Gly Glu Arg Leu Leu Gly 
385                 390                 395                 400 


Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro His His His His His 
                405                 410                 415     


His 
    


<210>  54
<211>  19
<212>  PRT
<213>  Murine

<400>  54

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  55
<211>  20
<212>  PRT
<213>  Murine

<400>  55

Met Glu Ser Gln Thr Gln Val Leu Met Phe Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Ala Cys Ala 
            20  


<210>  56
<211>  16
<212>  PRT
<213>  Human

<400>  56

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  57
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  H5L7, CDRL1 (Kabat defined)

<400>  57
aagagcagcc agagcctgct gaaccccagc aaccagaaga actacctggc c                51


<210>  58
<211>  21
<212>  DNA
<213>  Murine

<400>  58
ttcgcctcta ccagggattc c                                                 21


<210>  59
<211>  27
<212>  DNA
<213>  Murine

<400>  59
ctgcagcact tcggcacccc tcccact                                           27


<210>  60
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  H5L7, VL

<400>  60
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gt                         342


<210>  61
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H5L7, light chain humanised construct

<400>  61
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  62
<211>  15
<212>  DNA
<213>  Murine

<400>  62
gcctacggcg tcaac                                                        15


<210>  63
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  H5L7, CDRH2 (Kabat defined)

<400>  63
atgatctggg acgacggcag caccgactac gacagcgccc tgaagagc                    48


<210>  64
<211>  24
<212>  DNA
<213>  Murine

<400>  64
gagggcgacg tggccttcga ttac                                              24


<210>  65
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  H5L7, VH

<400>  65
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggctt ctccctgacc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacgac      180

agcgccctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagc                   348


<210>  66
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H5L7, heavy chain humanised construct

<400>  66
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggctt ctccctgacc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacgac      180

agcgccctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  67
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H1L7, light chain humanised construct

<400>  67
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  68
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H1L7, heavy chain humanised construct

<400>  68
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggctt ctccctgacc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  69
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  J7L7, light chain humanised construct

<400>  69
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  70
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  J7L7, heavy chain humanised construct

<400>  70
caggtgcagc tcgtgcagag cggggccgaa gtcaagaaac ccggcagctc cgtgaaggtg       60

agctgcaagg ccagcggctt ctctctcact gcctacggcg tgaactgggt gaggcaggct      120

cccggccagg gcctggagtg gatgggcatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcagggt gaccatcacc gccgacaaga gcaccagcac cgcctacatg      240

gaactgagca gcctgaggag cgaggacacc gccgtgtact attgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  71
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H4L7, light chain humanised construct

<400>  71
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  72
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H4L7, heavy chain humanised construct

<400>  72
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggctt ctccctgacc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gctggggatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcaggct gaccatcagc aaggacaaca gcaagaacca ggtgagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  73
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  J11L7, light chain humanised construct

<400>  73
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  74
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  J11L7, heavy chain humanised construct

<400>  74
caggtgcagc tcgtgcagag cggggccgaa gtcaagaaac ccggcagctc cgtgaaggtg       60

agctgcaagg ccagcggctt ctctctcact gcctacggcg tgaactgggt gaggcaggct      120

cccggccagg gcctggagtg gatgggcatg atctgggacg acggcagcac cgactacgac      180

agcgccctga agagcagggt gaccatcacc gccgacaaga gcaccagcac cgcctacatg      240

gaactgagca gcctgaggag cgaggacacc gccgtgtact attgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  75
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H2L7, light chain humanised construct

<400>  75
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  76
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H2L7, heavy chain humanised construct

<400>  76
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggctt ctccctgacc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcagggt gaccatcagc aaggacaaca gcaagaacca ggtgagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  77
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  J13L7, light chain humanised construct

<400>  77
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  78
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  J13L7, heavy chain humanised construct

<400>  78
caggtgcagc tcgtgcagag cggggccgaa gtcaagaaac ccggcagctc cgtgaaggtg       60

agctgcaagg ccagcggcgg caccttcagc gcctacggcg tgaactgggt gaggcaggct      120

cccggccagg gcctggagtg gatgggcatg atctgggacg acggcagcac cgactacgac      180

agcgccctga agagcagggt gaccatcacc gccgacaaga gcaccagcac cgcctacatg      240

gaactgagca gcctgaggag cgaggacacc gccgtgtact attgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  79
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H7L7, light chain humanised construct

<400>  79
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  80
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H7L7, heavy chain humanised construct

<400>  80
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggcgg ctccatcagc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacgac      180

agcgccctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  81
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  J0L7, light chain humanised construct

<400>  81
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  82
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  J0L7, heavy chain humanised construct

<400>  82
caggtgcagc tcgtgcagag cggggccgaa gtcaagaaac ccggcagctc cgtgaaggtg       60

agctgcaagg ccagcggcgg caccttcagc gcctacggcg tgaactgggt gaggcaggct      120

cccggccagg gcctggagtg gatgggcatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcagggt gaccatcacc gccgacaaga gcaccagcac cgcctacatg      240

gaactgagca gcctgaggag cgaggacacc gccgtgtact attgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  83
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H0L7, light chain humanised construct

<400>  83
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aaccccagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  84
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H0L7, heavy chain humanised construct

<400>  84
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggcgg ctccatcagc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  85
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H1L1, light chain humanised construct

<400>  85
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aacggcagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  86
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H1L1, heavy chain humanised construct

<400>  86
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggctt ctccctgacc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  87
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H5L1, light chain humanised construct

<400>  87
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aacggcagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  88
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H5L1, heavy chain humanised construct

<400>  88
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggctt ctccctgacc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacgac      180

agcgccctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  89
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  J7L1, light chain humanised construct

<400>  89
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aacggcagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  90
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  J7L1, heavy chain humanised construct

<400>  90
caggtgcagc tcgtgcagag cggggccgaa gtcaagaaac ccggcagctc cgtgaaggtg       60

agctgcaagg ccagcggctt ctctctcact gcctacggcg tgaactgggt gaggcaggct      120

cccggccagg gcctggagtg gatgggcatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcagggt gaccatcacc gccgacaaga gcaccagcac cgcctacatg      240

gaactgagca gcctgaggag cgaggacacc gccgtgtact attgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  91
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  J11L1, light chain humanised construct

<400>  91
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aacggcagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  92
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  J11L1, heavy chain humanised construct

<400>  92
caggtgcagc tcgtgcagag cggggccgaa gtcaagaaac ccggcagctc cgtgaaggtg       60

agctgcaagg ccagcggctt ctctctcact gcctacggcg tgaactgggt gaggcaggct      120

cccggccagg gcctggagtg gatgggcatg atctgggacg acggcagcac cgactacgac      180

agcgccctga agagcagggt gaccatcacc gccgacaaga gcaccagcac cgcctacatg      240

gaactgagca gcctgaggag cgaggacacc gccgtgtact attgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  93
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  J13L1, light chain humanised construct

<400>  93
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aacggcagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  94
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  J13L1, heavy chain humanised construct

<400>  94
caggtgcagc tcgtgcagag cggggccgaa gtcaagaaac ccggcagctc cgtgaaggtg       60

agctgcaagg ccagcggcgg caccttcagc gcctacggcg tgaactgggt gaggcaggct      120

cccggccagg gcctggagtg gatgggcatg atctgggacg acggcagcac cgactacgac      180

agcgccctga agagcagggt gaccatcacc gccgacaaga gcaccagcac cgcctacatg      240

gaactgagca gcctgaggag cgaggacacc gccgtgtact attgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  95
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H7L1, light chain humanised construct

<400>  95
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aacggcagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  96
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H7L1, heavy chain humanised construct

<400>  96
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggcgg ctccatcagc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacgac      180

agcgccctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  97
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  J0L1, light chain humanised construct

<400>  97
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aacggcagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  98
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  J0L1, heavy chain humanised construct

<400>  98
caggtgcagc tcgtgcagag cggggccgaa gtcaagaaac ccggcagctc cgtgaaggtg       60

agctgcaagg ccagcggcgg caccttcagc gcctacggcg tgaactgggt gaggcaggct      120

cccggccagg gcctggagtg gatgggcatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcagggt gaccatcacc gccgacaaga gcaccagcac cgcctacatg      240

gaactgagca gcctgaggag cgaggacacc gccgtgtact attgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  99
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  H0L1, light chain humanised construct

<400>  99
gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga cagggtgacc       60

atcacctgca agagcagcca gagcctgctg aacggcagca accagaagaa ctacctggcc      120

tggtaccagc agaaacccgg caaggccccc aagctgctgg tctacttcgc ctctaccagg      180

gattccggcg tccccagcag gttcagcggc agcggcagcg gcaccgactt cacactgacc      240

atcagcagcc tgcagcccga ggacttcgcc acctactact gcctgcagca cttcggcacc      300

cctcccactt ttggccaggg caccaagctg gagattaagc gtacggtggc cgcccccagc      360

gtgttcatct tcccccccag cgatgagcag ctgaagagcg gcaccgccag cgtggtgtgt      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caatgccctg      480

cagagcggca acagccagga gagcgtgacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgt      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaaccg gggcgagtgc      660


<210>  100
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  H0L1, heavy chain humanised construct

<400>  100
caggtgcagc tccaggagag cggccccggc ctggtgaagc ctagcgagac cctgagcctg       60

acctgcaccg tgagcggcgg ctccatcagc gcctacggcg tcaactggat caggcagccc      120

cccggcaaag gcctggagtg gattgggatg atctgggacg acggcagcac cgactacaac      180

agcgccctga agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgactgc cgccgacacc gccgtctatt actgcgccag ggagggcgac      300

gtggccttcg attactgggg ccagggcaca ctagtgaccg tgtccagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gaaccggtga ccgtgtcctg gaacagcgga      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac      660

aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc      720

ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt      780

gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt      960

aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc     1020

cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac     1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat     1200

ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac     1260

gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg     1320

agcctgtccc ctggcaag                                                   1338


<210>  101
<211>  318
<212>  DNA
<213>  Human

<400>  101
acggtggccg cccccagcgt gttcatcttc ccccccagcg atgagcagct gaagagcggc       60

accgccagcg tggtgtgtct gctgaacaac ttctaccccc gggaggccaa ggtgcagtgg      120

aaggtggaca atgccctgca gagcggcaac agccaggaga gcgtgaccga gcaggacagc      180

aaggactcca cctacagcct gagcagcacc ctgaccctga gcaaggccga ctacgagaag      240

cacaaggtgt acgcctgtga ggtgacccac cagggcctgt ccagccccgt gaccaagagc      300

ttcaaccggg gcgagtgc                                                    318


<210>  102
<211>  990
<212>  DNA
<213>  Human

<400>  102
gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc       60

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgaaccggt gaccgtgtcc      120

tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      180

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      240

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      300

aagagctgtg acaagaccca cacctgcccc ccctgccctg cccccgagct gctgggaggc      360

cccagcgtgt tcctgttccc ccccaagcct aaggacaccc tgatgatcag cagaaccccc      420

gaggtgacct gtgtggtggt ggatgtgagc cacgaggacc ctgaggtgaa gttcaactgg      480

tacgtggacg gcgtggaggt gcacaatgcc aagaccaagc ccagggagga gcagtacaac      540

agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaag      600

gagtacaagt gtaaggtgtc caacaaggcc ctgcctgccc ctatcgagaa aaccatcagc      660

aaggccaagg gccagcccag agagccccag gtgtacaccc tgccccctag cagagatgag      720

ctgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc      780

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg      840

ctggacagcg atggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg      900

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc      960

cagaagagcc tgagcctgtc ccctggcaag                                       990


<210>  103
<211>  348
<212>  DNA
<213>  Murine

<400>  103
caggtgcagc tgaaggagtc aggtcctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcaccg tctcagggtt ctcattaacc gcctatggtg taaactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggaatg atatgggatg atggaagcac agactataat      180

tcagctctca aatccagact gagcatcagt aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag agaaggggac      300

gtagcctttg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  104
<211>  342
<212>  DNA
<213>  Murine

<400>  104
gacattgtga tgacacagtc tccctcctcc ctggctgtgt cagtaggaca gaaggtcact       60

atgagctgca agtccagtca gagcctttta aatggtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg acagtctcct aaacttctgg tatactttgc atccactagg      180

gattctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gattacttct gtctgcaaca ttttggcact      300

cctccgacgt tcggtggagg caccaaactg gaaatcaaac gg                         342


<210>  105
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  IMP731, heavy chain sequence

<400>  105
caggtgcagc tgaaggagtc aggtcctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcaccg tctcagggtt ctcattaacc gcctatggtg taaactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggaatg atatgggatg atggaagcac agactataat      180

tcagctctca aatccagact gagcatcagt aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag agaaggggac      300

gtagcctttg actactgggg ccaaggcacc actctcacag tctcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  106
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  IMP731, light chain sequence

<400>  106
gacattgtga tgacacagtc tccctcctcc ctggctgtgt cagtaggaca gaaggtcact       60

atgagctgca agtccagtca gagcctttta aatggtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg acagtctcct aaacttctgg tatactttgc atccactagg      180

gattctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gattacttct gtctgcaaca ttttggcact      300

cctccgacgt tcggtggagg caccaaactg gaaatcaaac ggaccgtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagttcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  107
<211>  1251
<212>  DNA
<213>  Artificial

<220>
<223>  Recombinant human LAG-3-ECD-His6

<400>  107
ctccagccag gggctgaggt cccggtggtg tgggcccagg agggggctcc tgcccagctc       60

ccctgcagcc ccacaatccc cctccaggat ctcagccttc tgcgaagagc aggggtcact      120

tggcagcatc agccagacag tggcccgccc gctgccgccc ccggccatcc cctggccccc      180

ggccctcacc cggcggcgcc ctcctcctgg gggcccaggc cccgccgcta cacggtgctg      240

agcgtgggtc ccggaggcct gcgcagcggg aggctgcccc tgcagccccg cgtccagctg      300

gatgagcgcg gccggcagcg cggggacttc tcgctatggc tgcgcccagc ccggcgcgcg      360

gacgccggcg agtaccgcgc cgcggtgcac ctcagggacc gcgccctctc ctgccgcctc      420

cgtctgcgcc tgggccaggc ctcgatgact gccagccccc caggatctct cagagcctcc      480

gactgggtca ttttgaactg ctccttcagc cgccctgacc gcccagcctc tgtgcattgg      540

ttccggaacc ggggccaggg ccgagtccct gtccgggagt ccccccatca ccacttagcg      600

gaaagcttcc tcttcctgcc ccaagtcagc cccatggact ctgggccctg gggctgcatc      660

ctcacctaca gagatggctt caacgtctcc atcatgtata acctcactgt tctgggtctg      720

gagcccccaa ctcccttgac agtgtacgct ggagcaggtt ccagggtggg gctgccctgc      780

cgcctgcctg ctggtgtggg gacccggtct ttcctcactg ccaagtggac tcctcctggg      840

ggaggccctg acctcctggt gactggagac aatggcgact ttacccttcg actagaggat      900

gtgagccagg cccaggctgg gacctacacc tgccatatcc atctgcagga acagcagctc      960

aatgccactg tcacattggc aatcatcaca gtgactccca aatcctttgg gtcacctgga     1020

tccctgggga agctgctttg tgaggtgact ccagtatctg gacaagaacg ctttgtgtgg     1080

agctctctgg acaccccatc ccagaggagt ttctcaggac cttggctgga ggcacaggag     1140

gcccagctcc tttcccagcc ttggcaatgc cagctgtacc agggggagag gcttcttgga     1200

gcagcagtgt acttcacaga gctgtctagc ccacaccacc atcatcacca t              1251


<210>  108
<211>  1251
<212>  DNA
<213>  Artificial

<220>
<223>  Recombinant cynomolgus macaque LAG-3 ECD-His6

<400>  108
ccccagccag gggctgagat ctcggtggtg tgggcccagg agggggctcc tgcccagctc       60

ccctgcagcc ccacaatccc cctccaggat ctcagccttc tgcgaagagc aggggtcact      120

tggcagcatc aaccagacag tggcccgccc gctcccgccc ccggccaccc cccggccccc      180

ggccatcgcc cggcggcgcc ctactcttgg gggcccaggc cccgccgcta cacagtgctg      240

agcgtgggtc ctggaggcct gcgcagcggg aggctgcccc tgcagccccg cgtccagctg      300

gatgagcgcg gccggcagcg cggggacttc tcgctgtggc tgcgcccagc ccggcgcgcg      360

gacgccggcg agtaccgcgc cacggtgcac ctcagggacc gcgccctctc ctgccgcctt      420

cgtctgcgcg tgggccaggc ctcgatgact gccagccccc cagggtctct caggacctct      480

gactgggtca ttttgaactg ctccttcagc cgccctgacc gcccagcctc tgtgcattgg      540

ttccggagcc gtggccaggg ccgagtccct gtccaggggt ccccccatca ccacttagcg      600

gaaagcttcc tcttcctgcc ccatgtcggc cccatggact ctgggctctg gggctgcatc      660

ctcacctaca gagatggctt caatgtctcc atcatgtata acctcactgt tctgggtctg      720

gagcccgcaa ctcccttgac agtgtacgct ggagcaggtt ccagggtgga gctgccctgc      780

cgcctgcctc ctgctgtggg gacccagtct ttccttactg ccaagtgggc tcctcctggg      840

ggaggccctg acctcctggt ggctggagac aatggcgact ttacccttcg actagaggat      900

gtaagccagg cccaggctgg gacctacatc tgccatatcc gtctacaggg acagcagctc      960

aatgccactg tcacattggc aatcatcaca gtgactccca aatcctttgg gtcacctggc     1020

tccctgggga agctgctttg tgaggtgact ccagcatctg gacaagaaca ctttgtgtgg     1080

agccccctga acaccccatc ccagaggagt ttctcaggac catggctgga ggcccaggaa     1140

gcccagctcc tttcccagcc ttggcaatgc cagctgcacc agggggagag gcttcttgga     1200

gcagcagtat acttcacaga actgtctagc ccacaccacc atcatcacca t              1251


<210>  109
<211>  1251
<212>  DNA
<213>  Artificial

<220>
<223>  Recombinant baboon LAG-3 ECD-His6

<400>  109
ccccagccag gggctgagat ctcggtggtg tgggcccagg agggggctcc tgcccagctc       60

ccctgcagcc ccacaatccc cctccaggat ctcagccttc tgcgaagagc aggggtcact      120

tggcagcatc aaccagacag tggcccgccc gctcccgccc ccggccaccc cccggccccc      180

ggccatcgcc cggcggcgcc ctactcttgg gggcccaggc cccgccgcta cacagtgctg      240

agcgtgggtc ctggaggcct gcgcagcggg aggctgcccc tgcagccccg cgtccagctg      300

gatgagcgcg gccggcagcg cggggacttc tcgctgtggc tgcgcccagc ccggcgcgcg      360

gacgccggcg agtaccgcgc cacggtgcac ctcagggacc gcgccctctc ctgccgcctt      420

cgtctgcgcg tgggccaggc ctcgatgact gccagccccc cagggtctct caggacctct      480

gactgggtca ttttgaactg ctccttcagc cgccctgacc gcccagcctc tgtgcattgg      540

ttccggagcc gtggccaggg ccaagtccct gtccaggagt ccccccatca ccacttagcg      600

gaaagcttcc tcttcctgcc ccatgtcggc cccatggact ctgggctctg gggctgcatc      660

ctcacctaca gagatggctt caatgtctcc atcatgtata acctcactgt tctgggtctg      720

gagcccacaa ctcccttgac agtgtacgct ggagcaggtt ccagggtgga gctgccctgc      780

cgcctgcctc ctgctgtggg gacccagtct ttccttactg ccaagtgggc tcctcctggg      840

ggaggccctg acctcctggt ggttggagac aatggcaact ttacccttcg actagaggat      900

gtaagccagg cccaggctgg gacctacatc tgccatatcc gtctacaggg acagcagctc      960

aatgccactg tcacattggc aatcatcaca gtgactccca aatcctttgg gtcacctggc     1020

tccctgggga agctgctttg tgaggtgact ccagcatctg gacaagaacg ctttgtgtgg     1080

agccccctga acaccccatc ccagaggagt ttctcaggac cgtggctgga ggcccaggaa     1140

gcccagctcc tttcccagcc ttggcaatgc cagctgcacc agggggagag gcttcttgga     1200

gcagcagtat acttcacaga actgtctagc ccacaccacc atcatcacca t              1251


<210>  110
<211>  57
<212>  DNA
<213>  Murine

<400>  110
atgggctgga gctgcatcat cctgttcctg gtggccaccg ctaccggagt gcacagc          57


<210>  111
<211>  60
<212>  DNA
<213>  Murine

<400>  111
atggaatcac agacccaggt cctcatgttt cttctgctct gggtatctgg tgcctgtgca       60


<210>  112
<211>  48
<212>  DNA
<213>  Human

<400>  112
atgccgctgc tgctactgct gcccctgctg tgggcagggg cgctagct                    48


