                         SEQUENCE LISTING

<110>  Vaccibody AS
 
<120>  TARGETING VACCINES FOR VETERINARY USE

<130>  19601PCT00

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  DNA primer

<400>  1
tgctgtcttt gctgtcctga t                                                 21


<210>  2
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  DNA primer

<400>  2
atatgcggcc gcgggggggg gggggggg                                          28


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  DNA primer

<400>  3
ttgaccaggc atcccagggt c                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  DNA primer

<400>  4
caagaagcac acgactgagg c                                                 21


<210>  5
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  DNA primer

<400>  5
ggtgtgcatt ccatggactg gacctggagg                                        30


<210>  6
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  2G11 VH nucleotide sequence

<400>  6
gaggtgaagc tggtggagtc aggacctagc ctcgtgaaac cttctcagac tctgtccctc       60

acctgttctg tcacgggcga ctccatcacc agtggttatt ggaactggat ccggaaattc      120

ccagggaaaa aacttgaata catggggttc ataagctaca gtggtgacac ttattacaat      180

ccatctctca aaagtcgaat ctccatcact cgagacacat ccaagaacca gtaccacctg      240

cagttgaatt ctgtgacttc tgaggacaca gcaacatatt actgtgcaag aaggaactac      300

gttagtaact acggggggtg gtacttcggt gtctggggcg cagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  7
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  2G11 VH amino acid sequence

<400>  7

Glu Val Lys Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Lys Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Phe Ile Ser Tyr Ser Gly Asp Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr His Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Val Ser Asn Tyr Gly Gly Trp Tyr Phe Gly Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  2G11 VL nucleotide sequence

<400>  8
aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cagtaggaga gagagtcacc       60

ctgagctgca aggccagtga gaatgtggtt acttatgtat cctggtatca acagaaacca      120

gatcagtctc ctaaactgct gatatacggg gcatccaacc ggtacactgg ggtccctgat      180

cgcttcacag gcagtggatc tgcaacagat ttcactctta tcatcagcag tgttcaggct      240

gaagaccttg cagattatca ctgtggacag agttacacct atcctcccac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  9
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  2G11 VL amino acid sequence

<400>  9

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Ile Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Thr Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  10
<211>  732
<212>  DNA
<213>  Artificial

<220>
<223>  2G11 ScFv nucleotide sequence

<400>  10
aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cagtaggaga gagagtcacc       60

ctgagctgca aggccagtga gaatgtggtt acttatgtat cctggtatca acagaaacca      120

gatcagtctc ctaaactgct gatatacggg gcatccaacc ggtacactgg ggtccctgat      180

cgcttcacag gcagtggatc tgcaacagat ttcactctta tcatcagcag tgttcaggct      240

gaagaccttg cagattatca ctgtggacag agttacacct atcctcccac gttcggtgct      300

gggaccaagc tggagctgaa aggtggaggc ggatctggcg gaggtggctc tggcggtggc      360

ggatcggagg tgaagctggt ggagtcagga cctagcctcg tgaaaccttc tcagactctg      420

tccctcacct gttctgtcac gggcgactcc atcaccagtg gttattggaa ctggatccgg      480

aaattcccag ggaaaaaact tgaatacatg gggttcataa gctacagtgg tgacacttat      540

tacaatccat ctctcaaaag tcgaatctcc atcactcgag acacatccaa gaaccagtac      600

cacctgcagt tgaattctgt gacttctgag gacacagcaa catattactg tgcaagaagg      660

aactacgtta gtaactacgg ggggtggtac ttcggtgtct ggggcgcagg gaccacggtc      720

accgtctcct ca                                                          732


<210>  11
<211>  244
<212>  PRT
<213>  Artificial

<220>
<223>  2G11 ScFv coding amino acid sequence followed by linker and then 
       2G11 VH amino acid sequence

<400>  11

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Ile Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Thr Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu 
        115                 120                 125             


Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ser Val Thr Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn Trp Ile Arg 
145                 150                 155                 160 


Lys Phe Pro Gly Lys Lys Leu Glu Tyr Met Gly Phe Ile Ser Tyr Ser 
                165                 170                 175     


Gly Asp Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr 
            180                 185                 190         


Arg Asp Thr Ser Lys Asn Gln Tyr His Leu Gln Leu Asn Ser Val Thr 
        195                 200                 205             


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Asn Tyr Val Ser 
    210                 215                 220                 


Asn Tyr Gly Gly Trp Tyr Phe Gly Val Trp Gly Ala Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  12
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge h1+hinge h4, Gly-Ser linker and Gly-Leu linker iand hCH3 
       IgG3 domains

<400>  12

Gly Ala Gly Cys Thr Cys Ala Ala Ala Ala Cys Cys Cys Cys Ala Cys 
1               5                   10                  15      


Thr Thr Gly Gly Thr Gly Ala Cys Ala Cys Ala Ala Cys Thr Cys Ala 
            20                  25                  30          


Cys Ala Cys Ala Gly Ala Gly Cys Cys Cys Ala Ala Ala Thr Cys Thr 
        35                  40                  45              


Thr Gly Thr Gly Ala Cys Ala Cys Ala Cys Cys Thr Cys Cys Cys Cys 
    50                  55                  60                  


Cys Gly Thr Gly Cys Cys Cys Ala Ala Gly Gly Thr Gly Cys Cys Cys 
65                  70                  75                  80  


Ala Gly Gly Cys Gly Gly Thr Gly Gly Ala Ala Gly Cys Ala Gly Cys 
                85                  90                  95      


Gly Gly Ala Gly Gly Thr Gly Gly Ala Ala Gly Thr Gly Gly Ala Gly 
            100                 105                 110         


Gly Ala Cys Ala Gly Cys Cys Cys Cys Gly Ala Gly Ala Ala Cys Cys 
        115                 120                 125             


Ala Cys Ala Gly Gly Thr Gly Thr Ala Cys Ala Cys Cys Cys Thr Gly 
    130                 135                 140                 


Cys Cys Cys Cys Cys Ala Thr Cys Cys Cys Gly Gly Gly Ala Gly Gly 
145                 150                 155                 160 


Ala Gly Ala Thr Gly Ala Cys Cys Ala Ala Gly Ala Ala Cys Cys Ala 
                165                 170                 175     


Gly Gly Thr Cys Ala Gly Cys Cys Thr Gly Ala Cys Cys Thr Gly Cys 
            180                 185                 190         


Cys Thr Gly Gly Thr Cys Ala Ala Ala Gly Gly Cys Thr Thr Cys Thr 
        195                 200                 205             


Ala Cys Cys Cys Cys Ala Gly Cys Gly Ala Cys Ala Thr Cys Gly Cys 
    210                 215                 220                 


Cys Gly Thr Gly Gly Ala Gly Thr Gly Gly Gly Ala Gly Ala Gly Cys 
225                 230                 235                 240 


Ala Gly Cys Gly Gly Gly Cys Ala Gly Cys Cys Gly Gly Ala Gly Ala 
                245                 250                 255     


Ala Cys Ala Ala Cys Thr Ala Cys Ala Ala Cys Ala Cys Cys Ala Cys 
            260                 265                 270         


Gly Cys Cys Thr Cys Cys Cys Ala Thr Gly Cys Thr Gly Gly Ala Cys 
        275                 280                 285             


Thr Cys Cys Gly Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Thr 
    290                 295                 300                 


Thr Cys Cys Thr Cys Thr Ala Cys Ala Gly Cys Ala Ala Gly Cys Thr 
305                 310                 315                 320 


Cys Ala Cys Cys Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Gly Cys 
                325                 330                 335     


Ala Gly Gly Thr Gly Gly Cys Ala Gly Cys Ala Gly Gly Gly Gly Ala 
            340                 345                 350         


Ala Cys Ala Thr Cys Thr Thr Cys Thr Cys Ala Thr Gly Cys Thr Cys 
        355                 360                 365             


Cys Gly Thr Gly Ala Thr Gly Cys Ala Thr Gly Ala Gly Gly Cys Thr 
    370                 375                 380                 


Cys Thr Gly Cys Ala Cys Ala Ala Cys Cys Gly Cys Thr Thr Cys Ala 
385                 390                 395                 400 


Cys Gly Cys Ala Gly Ala Ala Gly Ala Gly Cys Cys Thr Cys Thr Cys 
                405                 410                 415     


Cys Cys Thr Gly Thr Cys Thr Cys Cys Gly Gly Gly Thr Ala Ala Ala 
            420                 425                 430         


Gly Gly Cys Cys Thr Cys Gly Gly Thr Gly Gly Cys Cys Thr Gly 
        435                 440                 445         


<210>  13
<211>  149
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge h1, Hinge h4, linker and hCH3 IgG3 domains

<400>  13

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Pro Lys Ser 
1               5                   10                  15      


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        35                  40                  45              


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    50                  55                  60                  


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
65                  70                  75                  80  


Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp 
                85                  90                  95      


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            100                 105                 110         


Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala 
        115                 120                 125             


Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    130                 135                 140                 


Gly Leu Gly Gly Leu 
145                 


<210>  14
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge regions (IgG3 upper hinge)

<400>  14

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  15
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Hinge region (IgG3, lower hinge, 15 amino acids)

<400>  15

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Gly-Ser Linker

<400>  16

Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly 
1               5                   10  


<210>  17
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  hCH3 IgG3

<400>  17

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  18
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  18

Gly Leu Gly Gly Leu 
1               5   


<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Upper hinge hIgG3 (h1)

<400>  20

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  21
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Lower hinge hIgG3 (h4)

<400>  21

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210>  22
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  CH3 hIgG3

<400>  22

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  23
<211>  350
<212>  PRT
<213>  Artificial

<220>
<223>  glycoprotein D from Herpes Simplex virus 2 with an optional 
       His-tag

<400>  23

Met Gly Arg Leu Thr Ser Gly Val Gly Thr Ala Ala Leu Leu Val Val 
1               5                   10                  15      


Ala Val Gly Leu Arg Val Val Cys Ala Lys Tyr Ala Leu Ala Asp Pro 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Lys Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Pro Ser Leu Glu Asp Pro Phe Gln Pro Pro Ser Ile Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


His Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Asp Glu 
            100                 105                 110         


Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala Trp Tyr Arg Met Gly 
        115                 120                 125             


Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Pro 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Leu Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Ala Gly Thr Val Ser Ser Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Val Ala Pro His His Ala Pro Ala Ala Pro 
                325                 330                 335     


Ser Asn Pro Gly Leu Ile Thr Gly His His His His His His 
            340                 345                 350 


<210>  24
<211>  743
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of suitable chicken vaccibody construct: 
       Targeting unit: anti-chicken MHC II scFv, dimerization unit: 
       human shortened hinge (h1+h4), antigenic unit: gD from herpes 
       simplex virus 2 + an optional 6xHis-tag

<400>  24

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Ile Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Thr Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu 
        115                 120                 125             


Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ser Val Thr Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn Trp Ile Arg 
145                 150                 155                 160 


Lys Phe Pro Gly Lys Lys Leu Glu Tyr Met Gly Phe Ile Ser Tyr Ser 
                165                 170                 175     


Gly Asp Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr 
            180                 185                 190         


Arg Asp Thr Ser Lys Asn Gln Tyr His Leu Gln Leu Asn Ser Val Thr 
        195                 200                 205             


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Asn Tyr Val Ser 
    210                 215                 220                 


Asn Tyr Gly Gly Trp Tyr Phe Gly Val Trp Gly Ala Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
                245                 250                 255     


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln 
        275                 280                 285             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    290                 295                 300                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
305                 310                 315                 320 


Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro 
                325                 330                 335     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            340                 345                 350         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val 
        355                 360                 365             


Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
    370                 375                 380                 


Ser Pro Gly Lys Gly Leu Gly Gly Leu Met Gly Arg Leu Thr Ser Gly 
385                 390                 395                 400 


Val Gly Thr Ala Ala Leu Leu Val Val Ala Val Gly Leu Arg Val Val 
                405                 410                 415     


Cys Ala Lys Tyr Ala Leu Ala Asp Pro Ser Leu Lys Met Ala Asp Pro 
            420                 425                 430         


Asn Arg Phe Arg Gly Lys Asn Leu Pro Val Leu Asp Gln Leu Thr Asp 
        435                 440                 445             


Pro Pro Gly Val Lys Arg Val Tyr His Ile Gln Pro Ser Leu Glu Asp 
    450                 455                 460                 


Pro Phe Gln Pro Pro Ser Ile Pro Ile Thr Val Tyr Tyr Ala Val Leu 
465                 470                 475                 480 


Glu Arg Ala Cys Arg Ser Val Leu Leu His Ala Pro Ser Glu Ala Pro 
                485                 490                 495     


Gln Ile Val Arg Gly Ala Ser Asp Glu Ala Arg Lys His Thr Tyr Asn 
            500                 505                 510         


Leu Thr Ile Ala Trp Tyr Arg Met Gly Asp Asn Cys Ala Ile Pro Ile 
        515                 520                 525             


Thr Val Met Glu Tyr Thr Glu Cys Pro Tyr Asn Lys Ser Leu Gly Val 
    530                 535                 540                 


Cys Pro Ile Arg Thr Gln Pro Arg Trp Ser Tyr Tyr Asp Ser Phe Ser 
545                 550                 555                 560 


Ala Val Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe 
                565                 570                 575     


Glu Thr Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr 
            580                 585                 590         


Glu Ile Thr Gln Phe Ile Leu Glu His Arg Ala Arg Ala Ser Cys Lys 
        595                 600                 605             


Tyr Ala Leu Pro Leu Arg Ile Pro Pro Ala Ala Cys Leu Thr Ser Lys 
    610                 615                 620                 


Ala Tyr Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met Leu Pro Arg 
625                 630                 635                 640 


Phe Ile Pro Glu Asn Gln Arg Thr Val Ala Leu Tyr Ser Leu Lys Ile 
                645                 650                 655     


Ala Gly Trp His Gly Pro Lys Pro Pro Tyr Thr Ser Thr Leu Leu Pro 
            660                 665                 670         


Pro Glu Leu Ser Asp Thr Thr Asn Ala Thr Gln Pro Glu Leu Val Pro 
        675                 680                 685             


Glu Asp Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Ala Gly Thr Val 
    690                 695                 700                 


Ser Ser Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gln Asp Val 
705                 710                 715                 720 


Ala Pro His His Ala Pro Ala Ala Pro Ser Asn Pro Gly Leu Ile Thr 
                725                 730                 735     


Gly His His His His His His 
            740             


<210>  25
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Chicken IgY CH2

<400>  25

His Pro Ser Ser Cys Thr Pro Ser Gln Ser Glu Ser Val Glu Leu Leu 
1               5                   10                  15      


Cys Leu Val Thr Gly Phe Ser Pro Ala Ser Ala Glu Val Glu Trp Leu 
            20                  25                  30          


Val Asp Gly Val Gly Gly Leu Leu Val Ala Ser Gln Ser Pro Ala Val 
        35                  40                  45              


Arg Ser Gly Ser Thr Tyr Ser Leu Ser Ser Arg Val Asn Val Ser Gly 
    50                  55                  60                  


Thr Asp Trp Arg Glu Gly Lys Ser Tyr Ser Cys Arg Val Arg His Pro 
65                  70                  75                  80  


Ala Thr Asn Thr Val Val Glu Asp His Val Lys Gly Cys Pro 
                85                  90                  


<210>  26
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Chicken IgY CH4

<400>  26

Gly Pro Thr Thr Pro Pro Leu Ile Tyr Pro Phe Ala Pro His Pro Glu 
1               5                   10                  15      


Glu Leu Ser Leu Ser Arg Val Thr Leu Ser Cys Leu Val Arg Gly Phe 
            20                  25                  30          


Arg Pro Arg Asp Ile Glu Ile Arg Trp Leu Arg Asp His Arg Ala Val 
        35                  40                  45              


Pro Ala Thr Glu Phe Val Thr Thr Ala Val Leu Pro Glu Glu Arg Thr 
    50                  55                  60                  


Ala Asn Gly Ala Gly Gly Asp Gly Asp Thr Phe Phe Val Tyr Ser Lys 
65                  70                  75                  80  


Met Ser Val Glu Thr Ala Lys Trp Asn Gly Gly Thr Val Phe Ala Cys 
                85                  90                  95      


Met Ala Val His Glu Ala Leu Pro Met Arg Phe Ser Gln Arg Thr Leu 
            100                 105                 110         


Gln Lys Gln Ala Gly Lys 
        115             


<210>  27
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Upper CH2 sequence IgY

<400>  27

Glu Trp Leu Val Asp Gly Val Gly Gly Leu 
1               5                   10  


<210>  28
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Lower CH2 sequence IgY

<400>  28

Glu Gly Lys Ser Tyr Ser Cys Arg Val Arg His Pro Ala Thr Asn Thr 
1               5                   10                  15      


Val Val Glu Asp His Val Lys Gly Cys Pro 
            20                  25      


<210>  29
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Extended lower CH2 sequence IgY

<400>  29

Val Ser Gly Thr Asp Trp Arg Glu Gly Lys Ser Tyr Ser Cys Arg Val 
1               5                   10                  15      


Arg His Pro Ala Thr Asn Thr Val Val Glu Asp His Val Lys Gly Cys 
            20                  25                  30          


Pro 
    


<210>  30
<211>  527
<212>  PRT
<213>  Artificial

<220>
<223>  Shortened HA5 with polybasic deletion from  influenza A/VietNam 
       1203/04 H5N1

<400>  30

Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
1               5                   10                  15      


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
            20                  25                  30          


Leu Glu Lys Lys His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
        35                  40                  45              


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
    50                  55                  60                  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn 
                85                  90                  95      


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
            100                 105                 110         


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser 
        115                 120                 125             


Leu Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe 
    130                 135                 140                 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
145                 150                 155                 160 


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
            180                 185                 190         


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
        195                 200                 205             


Leu Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
    210                 215                 220                 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
                245                 250                 255     


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
            260                 265                 270         


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
305                 310                 315                 320 


Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
                325                 330                 335     


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
            340                 345                 350         


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
        355                 360                 365             


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
    370                 375                 380                 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
385                 390                 395                 400 


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
                405                 410                 415     


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
            420                 425                 430         


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
        435                 440                 445             


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
    450                 455                 460                 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
465                 470                 475                 480 


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
                485                 490                 495     


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
            500                 505                 510         


Ile Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu 
        515                 520                 525         


<210>  31
<211>  940
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of suitable chicken vaccibody construct: 
       Targeting unit: anti-chicken MHC II, dimerization unit: shortened
       CH2 (lower + upper CH2) + entire CH4, antigenic unit: H5 from 
       influenza

<400>  31

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Ile Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Thr Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu 
        115                 120                 125             


Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ser Val Thr Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn Trp Ile Arg 
145                 150                 155                 160 


Lys Phe Pro Gly Lys Lys Leu Glu Tyr Met Gly Phe Ile Ser Tyr Ser 
                165                 170                 175     


Gly Asp Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr 
            180                 185                 190         


Arg Asp Thr Ser Lys Asn Gln Tyr His Leu Gln Leu Asn Ser Val Thr 
        195                 200                 205             


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Asn Tyr Val Ser 
    210                 215                 220                 


Asn Tyr Gly Gly Trp Tyr Phe Gly Val Trp Gly Ala Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Trp Leu Val Asp Gly Val Gly Gly Leu Glu Gly 
                245                 250                 255     


Lys Ser Tyr Ser Cys Arg Val Arg His Pro Ala Thr Asn Thr Val Val 
            260                 265                 270         


Glu Asp His Val Lys Gly Cys Pro Gly Gly Gly Ser Ser Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Pro Thr Thr Pro Pro Leu Ile Tyr Pro Phe Ala Pro His 
    290                 295                 300                 


Pro Glu Glu Leu Ser Leu Ser Arg Val Thr Leu Ser Cys Leu Val Arg 
305                 310                 315                 320 


Gly Phe Arg Pro Arg Asp Ile Glu Ile Arg Trp Leu Arg Asp His Arg 
                325                 330                 335     


Ala Val Pro Ala Thr Glu Phe Val Thr Thr Ala Val Leu Pro Glu Glu 
            340                 345                 350         


Arg Thr Ala Asn Gly Ala Gly Gly Asp Gly Asp Thr Phe Phe Val Tyr 
        355                 360                 365             


Ser Lys Met Ser Val Glu Thr Ala Lys Trp Asn Gly Gly Thr Val Phe 
    370                 375                 380                 


Ala Cys Met Ala Val His Glu Ala Leu Pro Met Arg Phe Ser Gln Arg 
385                 390                 395                 400 


Thr Leu Gln Lys Gln Ala Gly Lys Gly Leu Gly Gly Leu Asp Gln Ile 
                405                 410                 415     


Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile 
            420                 425                 430         


Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys 
        435                 440                 445             


Lys His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile 
    450                 455                 460                 


Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys 
465                 470                 475                 480 


Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala 
                485                 490                 495     


Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn Asp Tyr Glu 
            500                 505                 510         


Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln 
        515                 520                 525             


Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser Leu Gly Val 
    530                 535                 540                 


Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe Arg Asn Val 
545                 550                 555                 560 


Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile Lys Arg Ser 
                565                 570                 575     


Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His 
            580                 585                 590         


His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln Asn Pro Thr 
        595                 600                 605             


Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro 
    610                 615                 620                 


Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu 
625                 630                 635                 640 


Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser 
                645                 650                 655     


Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys 
            660                 665                 670         


Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn 
        675                 680                 685             


Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe 
    690                 695                 700                 


His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys 
705                 710                 715                 720 


Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Arg 
                725                 730                 735     


Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            740                 745                 750         


Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        755                 760                 765             


His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr 
    770                 775                 780                 


Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp 
785                 790                 795                 800 


Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu 
                805                 810                 815     


Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu 
            820                 825                 830         


Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu 
        835                 840                 845             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys 
    850                 855                 860                 


Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys 
865                 870                 875                 880 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                885                 890                 895     


Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys 
            900                 905                 910         


Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Ile Tyr Gln 
        915                 920                 925             


Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu 
    930                 935                 940 


<210>  32
<211>  937
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 2 with an extended lower CH2 sequence

<400>  32

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Ile Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Thr Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu 
        115                 120                 125             


Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ser Val Thr Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn Trp Ile Arg 
145                 150                 155                 160 


Lys Phe Pro Gly Lys Lys Leu Glu Tyr Met Gly Phe Ile Ser Tyr Ser 
                165                 170                 175     


Gly Asp Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr 
            180                 185                 190         


Arg Asp Thr Ser Lys Asn Gln Tyr His Leu Gln Leu Asn Ser Val Thr 
        195                 200                 205             


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Asn Tyr Val Ser 
    210                 215                 220                 


Asn Tyr Gly Gly Trp Tyr Phe Gly Val Trp Gly Ala Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser Val Ser Gly Thr Asp Trp Arg Glu Gly Lys Ser Tyr 
                245                 250                 255     


Ser Cys Arg Val Arg His Pro Ala Thr Asn Thr Val Val Glu Asp His 
            260                 265                 270         


Val Lys Gly Cys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Pro Thr Thr Pro Pro Leu Ile Tyr Pro Phe Ala Pro His Pro Glu Glu 
    290                 295                 300                 


Leu Ser Leu Ser Arg Val Thr Leu Ser Cys Leu Val Arg Gly Phe Arg 
305                 310                 315                 320 


Pro Arg Asp Ile Glu Ile Arg Trp Leu Arg Asp His Arg Ala Val Pro 
                325                 330                 335     


Ala Thr Glu Phe Val Thr Thr Ala Val Leu Pro Glu Glu Arg Thr Ala 
            340                 345                 350         


Asn Gly Ala Gly Gly Asp Gly Asp Thr Phe Phe Val Tyr Ser Lys Met 
        355                 360                 365             


Ser Val Glu Thr Ala Lys Trp Asn Gly Gly Thr Val Phe Ala Cys Met 
    370                 375                 380                 


Ala Val His Glu Ala Leu Pro Met Arg Phe Ser Gln Arg Thr Leu Gln 
385                 390                 395                 400 


Lys Gln Ala Gly Lys Gly Leu Gly Gly Leu Asp Gln Ile Cys Ile Gly 
                405                 410                 415     


Tyr His Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met Glu Lys 
            420                 425                 430         


Asn Val Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Lys His Asn 
        435                 440                 445             


Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile Leu Arg Asp 
    450                 455                 460                 


Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp Glu Phe 
465                 470                 475                 480 


Ile Asn Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala Asn Pro Val 
                485                 490                 495     


Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn Asp Tyr Glu Glu Leu Lys 
            500                 505                 510         


His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln Ile Ile Pro 
        515                 520                 525             


Lys Ser Ser Trp Ser Ser His Glu Ala Ser Leu Gly Val Ser Ser Ala 
    530                 535                 540                 


Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe Arg Asn Val Val Trp Leu 
545                 550                 555                 560 


Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile Lys Arg Ser Tyr Asn Asn 
                565                 570                 575     


Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His His Pro Asn 
            580                 585                 590         


Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln Asn Pro Thr Thr Tyr Ile 
        595                 600                 605             


Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Arg Ile Ala 
    610                 615                 620                 


Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu Phe Phe Trp 
625                 630                 635                 640 


Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser Asn Gly Asn 
                645                 650                 655     


Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys Gly Asp Ser 
            660                 665                 670         


Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn Thr Lys Cys 
        675                 680                 685             


Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile 
    690                 695                 700                 


His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Arg 
705                 710                 715                 720 


Leu Val Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Arg Glu Arg Arg 
                725                 730                 735     


Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
            740                 745                 750         


Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn 
        755                 760                 765             


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala 
    770                 775                 780                 


Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn 
785                 790                 795                 800 


Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg 
                805                 810                 815     


Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp 
            820                 825                 830         


Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu 
        835                 840                 845             


Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Leu 
    850                 855                 860                 


Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe 
865                 870                 875                 880 


Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr 
                885                 890                 895     


Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu 
            900                 905                 910         


Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Ile Tyr Gln Ile Leu Ser 
        915                 920                 925             


Ile Tyr Ser Thr Val Ala Ser Ser Leu 
    930                 935         


<210>  33
<211>  3039
<212>  PRT
<213>  Artificial

<220>
<223>  Infectious bursal disease virus viral protein 2, viral protein 4 
       and viral protein 3 of segment A (VP2-VP4-VP3)

<400>  33

Ala Thr Gly Ala Cys Ala Ala Ala Cys Cys Thr Gly Cys Ala Ala Gly 
1               5                   10                  15      


Ala Thr Cys Ala Ala Ala Cys Cys Cys Ala Ala Cys Ala Gly Ala Thr 
            20                  25                  30          


Thr Gly Thr Thr Cys Cys Gly Thr Thr Cys Ala Thr Ala Cys Gly Gly 
        35                  40                  45              


Ala Gly Cys Cys Thr Thr Cys Thr Gly Ala Thr Gly Cys Cys Ala Ala 
    50                  55                  60                  


Cys Ala Ala Cys Cys Gly Gly Ala Cys Cys Gly Gly Cys Gly Thr Cys 
65                  70                  75                  80  


Cys Ala Thr Thr Cys Cys Gly Gly Ala Cys Gly Ala Cys Ala Cys Cys 
                85                  90                  95      


Cys Thr Ala Gly Ala Gly Ala Ala Gly Cys Ala Cys Ala Cys Thr Cys 
            100                 105                 110         


Thr Cys Ala Gly Gly Thr Cys Ala Gly Ala Gly Ala Cys Cys Thr Cys 
        115                 120                 125             


Gly Ala Cys Cys Thr Ala Cys Ala Ala Thr Thr Thr Gly Ala Cys Thr 
    130                 135                 140                 


Gly Thr Gly Gly Gly Gly Gly Ala Cys Ala Cys Ala Gly Gly Gly Thr 
145                 150                 155                 160 


Cys Ala Gly Gly Gly Cys Thr Ala Ala Thr Thr Gly Thr Cys Thr Thr 
                165                 170                 175     


Thr Thr Thr Cys Cys Cys Thr Gly Gly Thr Thr Thr Cys Cys Cys Thr 
            180                 185                 190         


Gly Gly Cys Thr Cys Ala Ala Thr Thr Gly Thr Gly Gly Gly Thr Gly 
        195                 200                 205             


Cys Thr Cys Ala Cys Thr Ala Cys Ala Cys Ala Cys Thr Gly Cys Ala 
    210                 215                 220                 


Gly Ala Gly Cys Ala Ala Thr Gly Gly Gly Ala Ala Cys Thr Ala Cys 
225                 230                 235                 240 


Ala Ala Gly Thr Thr Cys Gly Ala Thr Cys Ala Gly Ala Thr Gly Cys 
                245                 250                 255     


Thr Cys Cys Thr Gly Ala Cys Thr Gly Cys Cys Cys Ala Gly Ala Ala 
            260                 265                 270         


Cys Cys Thr Ala Cys Cys Gly Gly Cys Cys Ala Gly Cys Thr Ala Cys 
        275                 280                 285             


Ala Ala Cys Thr Ala Cys Thr Gly Cys Ala Gly Gly Cys Thr Ala Gly 
    290                 295                 300                 


Thr Gly Ala Gly Thr Cys Gly Gly Ala Gly Thr Cys Thr Cys Ala Cys 
305                 310                 315                 320 


Ala Gly Thr Gly Ala Gly Gly Thr Cys Ala Ala Gly Cys Ala Cys Ala 
                325                 330                 335     


Cys Thr Cys Cys Cys Thr Gly Gly Thr Gly Gly Cys Gly Thr Thr Thr 
            340                 345                 350         


Ala Thr Gly Cys Ala Cys Thr Ala Ala Ala Thr Gly Gly Cys Ala Cys 
        355                 360                 365             


Cys Ala Thr Ala Ala Ala Cys Gly Cys Cys Gly Thr Gly Ala Cys Cys 
    370                 375                 380                 


Thr Thr Cys Cys Ala Ala Gly Gly Ala Ala Gly Cys Cys Thr Gly Ala 
385                 390                 395                 400 


Gly Thr Gly Ala Ala Cys Thr Gly Ala Cys Ala Gly Ala Thr Gly Thr 
                405                 410                 415     


Thr Ala Gly Cys Thr Ala Cys Ala Ala Thr Gly Gly Gly Thr Thr Gly 
            420                 425                 430         


Ala Thr Gly Thr Cys Thr Gly Cys Ala Ala Cys Ala Gly Cys Cys Ala 
        435                 440                 445             


Ala Cys Ala Thr Cys Ala Ala Cys Gly Ala Cys Ala Ala Ala Ala Thr 
    450                 455                 460                 


Cys Gly Gly Gly Ala Ala Cys Gly Thr Cys Cys Thr Ala Gly Thr Ala 
465                 470                 475                 480 


Gly Gly Gly Gly Ala Ala Gly Gly Gly Gly Thr Ala Ala Cys Cys Gly 
                485                 490                 495     


Thr Cys Cys Thr Cys Ala Gly Cys Thr Thr Ala Cys Cys Cys Ala Cys 
            500                 505                 510         


Ala Thr Cys Ala Thr Ala Thr Gly Ala Thr Cys Thr Thr Gly Gly Gly 
        515                 520                 525             


Thr Ala Thr Gly Thr Gly Ala Gly Ala Cys Thr Cys Gly Gly Thr Gly 
    530                 535                 540                 


Ala Cys Cys Cys Cys Ala Thr Thr Cys Cys Cys Gly Cys Thr Ala Thr 
545                 550                 555                 560 


Ala Gly Gly Gly Cys Thr Cys Gly Ala Cys Cys Cys Ala Ala Ala Ala 
                565                 570                 575     


Ala Thr Gly Gly Thr Ala Gly Cys Ala Ala Cys Ala Thr Gly Thr Gly 
            580                 585                 590         


Ala Cys Ala Gly Cys Ala Gly Thr Gly Ala Cys Ala Gly Gly Cys Cys 
        595                 600                 605             


Cys Ala Gly Ala Gly Thr Cys Thr Ala Cys Ala Cys Cys Ala Thr Ala 
    610                 615                 620                 


Ala Cys Thr Gly Cys Ala Gly Cys Cys Gly Ala Thr Gly Ala Thr Thr 
625                 630                 635                 640 


Ala Cys Cys Ala Ala Thr Thr Cys Thr Cys Ala Thr Cys Ala Cys Ala 
                645                 650                 655     


Gly Thr Ala Cys Cys Ala Gly Gly Cys Ala Gly Gly Thr Gly Gly Gly 
            660                 665                 670         


Gly Thr Ala Ala Cys Ala Ala Thr Cys Ala Cys Ala Cys Thr Gly Thr 
        675                 680                 685             


Thr Cys Thr Cys Ala Gly Cys Thr Ala Ala Thr Ala Thr Cys Gly Ala 
    690                 695                 700                 


Thr Gly Cys Cys Ala Thr Cys Ala Cys Ala Ala Gly Cys Cys Thr Cys 
705                 710                 715                 720 


Ala Gly Cys Ala Thr Thr Gly Gly Gly Gly Gly Ala Gly Ala Ala Cys 
                725                 730                 735     


Thr Cys Gly Thr Gly Thr Thr Cys Cys Ala Ala Ala Cys Ala Ala Gly 
            740                 745                 750         


Cys Gly Thr Cys Cys Ala Ala Gly Gly Cys Cys Thr Thr Ala Thr Ala 
        755                 760                 765             


Cys Thr Gly Gly Gly Thr Gly Cys Thr Ala Cys Cys Ala Thr Cys Thr 
    770                 775                 780                 


Ala Cys Cys Thr Thr Ala Thr Ala Gly Gly Cys Thr Thr Thr Gly Ala 
785                 790                 795                 800 


Thr Gly Gly Gly Ala Cys Thr Gly Cys Gly Gly Thr Ala Ala Thr Cys 
                805                 810                 815     


Ala Cys Cys Ala Gly Ala Gly Cys Thr Gly Thr Gly Gly Cys Cys Gly 
            820                 825                 830         


Cys Ala Gly Ala Cys Ala Ala Thr Gly Gly Gly Cys Thr Ala Ala Cys 
        835                 840                 845             


Gly Gly Cys Cys Gly Gly Cys Ala Cys Thr Gly Ala Cys Ala Ala Cys 
    850                 855                 860                 


Cys Thr Thr Ala Thr Gly Cys Cys Ala Thr Thr Cys Ala Ala Thr Ala 
865                 870                 875                 880 


Thr Thr Gly Thr Gly Ala Thr Thr Cys Cys Ala Ala Cys Cys Ala Gly 
                885                 890                 895     


Cys Gly Ala Gly Ala Thr Ala Ala Cys Cys Cys Ala Gly Cys Cys Ala 
            900                 905                 910         


Ala Thr Cys Ala Cys Ala Thr Cys Cys Ala Thr Cys Ala Ala Ala Cys 
        915                 920                 925             


Thr Gly Gly Ala Gly Ala Thr Ala Gly Thr Gly Ala Cys Cys Thr Cys 
    930                 935                 940                 


Cys Ala Ala Ala Ala Gly Thr Gly Gly Thr Gly Gly Thr Cys Ala Gly 
945                 950                 955                 960 


Gly Cys Gly Gly Gly Gly Gly Ala Cys Cys Ala Gly Ala Thr Gly Thr 
                965                 970                 975     


Cys Ala Thr Gly Gly Thr Cys Ala Gly Cys Ala Ala Gly Thr Gly Gly 
            980                 985                 990         


Gly Ala Gly Cys Cys Thr Ala Gly  Cys Ala Gly Thr Gly  Ala Cys Gly 
        995                 1000                 1005             


Ala Thr  Cys Cys Ala Cys Gly  Gly Thr Gly Gly Cys  Ala Ala Cys 
    1010                 1015                 1020             


Thr Ala  Thr Cys Cys Ala Gly  Gly Gly Gly Cys Cys  Cys Thr Cys 
    1025                 1030                 1035             


Cys Gly  Thr Cys Cys Cys Gly  Thr Cys Ala Cys Ala  Cys Thr Ala 
    1040                 1045                 1050             


Gly Thr  Ala Gly Cys Cys Thr  Ala Cys Gly Ala Ala  Ala Gly Ala 
    1055                 1060                 1065             


Gly Thr  Gly Gly Cys Ala Ala  Cys Ala Gly Gly Ala  Thr Cys Thr 
    1070                 1075                 1080             


Gly Thr  Cys Gly Thr Thr Ala  Cys Gly Gly Thr Cys  Gly Cys Cys 
    1085                 1090                 1095             


Gly Gly  Gly Gly Thr Gly Ala  Gly Cys Ala Ala Cys  Thr Thr Cys 
    1100                 1105                 1110             


Gly Ala  Gly Cys Thr Gly Ala  Thr Cys Cys Cys Ala  Ala Ala Thr 
    1115                 1120                 1125             


Cys Cys  Thr Gly Ala Ala Cys  Thr Ala Gly Cys Ala  Ala Ala Gly 
    1130                 1135                 1140             


Ala Ala  Cys Cys Thr Gly Gly  Thr Cys Ala Cys Ala  Gly Ala Ala 
    1145                 1150                 1155             


Thr Ala  Cys Gly Gly Cys Cys  Gly Ala Thr Thr Thr  Gly Ala Cys 
    1160                 1165                 1170             


Cys Cys  Ala Gly Gly Ala Gly  Cys Cys Ala Thr Gly  Ala Ala Cys 
    1175                 1180                 1185             


Thr Ala  Cys Ala Cys Ala Ala  Ala Ala Thr Thr Gly  Ala Thr Ala 
    1190                 1195                 1200             


Cys Thr  Gly Ala Gly Thr Gly  Ala Gly Ala Gly Gly  Gly Ala Cys 
    1205                 1210                 1215             


Cys Gly  Thr Cys Thr Thr Gly  Gly Cys Ala Thr Cys  Ala Ala Gly 
    1220                 1225                 1230             


Ala Cys  Cys Gly Thr Ala Thr  Gly Gly Cys Cys Ala  Ala Cys Ala 
    1235                 1240                 1245             


Ala Gly  Gly Gly Ala Gly Thr  Ala Cys Ala Cys Thr  Gly Ala Cys 
    1250                 1255                 1260             


Thr Thr  Thr Cys Gly Cys Gly  Ala Gly Thr Ala Cys  Thr Thr Cys 
    1265                 1270                 1275             


Ala Thr  Gly Gly Ala Gly Gly  Thr Gly Gly Cys Cys  Gly Ala Cys 
    1280                 1285                 1290             


Cys Thr  Cys Ala Ala Cys Thr  Cys Thr Cys Cys Cys  Cys Thr Gly 
    1295                 1300                 1305             


Ala Ala  Gly Ala Thr Thr Gly  Cys Ala Gly Gly Ala  Gly Cys Ala 
    1310                 1315                 1320             


Thr Thr  Thr Gly Gly Cys Thr  Thr Cys Ala Ala Ala  Gly Ala Cys 
    1325                 1330                 1335             


Ala Thr  Ala Ala Thr Cys Cys  Gly Gly Gly Cys Cys  Ala Thr Ala 
    1340                 1345                 1350             


Ala Gly  Gly Ala Gly Gly Ala  Thr Ala Gly Cys Thr  Gly Thr Gly 
    1355                 1360                 1365             


Cys Cys  Gly Gly Thr Gly Gly  Thr Cys Thr Cys Thr  Ala Cys Ala 
    1370                 1375                 1380             


Thr Thr  Gly Thr Thr Cys Cys  Cys Ala Cys Cys Cys  Gly Cys Cys 
    1385                 1390                 1395             


Gly Cys  Thr Cys Cys Cys Cys  Thr Ala Gly Cys Cys  Cys Ala Thr 
    1400                 1405                 1410             


Gly Cys  Ala Ala Thr Thr Gly  Gly Gly Gly Ala Ala  Gly Gly Thr 
    1415                 1420                 1425             


Gly Thr  Ala Gly Ala Cys Thr  Ala Cys Cys Thr Gly  Cys Thr Gly 
    1430                 1435                 1440             


Gly Gly  Cys Gly Ala Thr Gly  Ala Gly Gly Cys Ala  Cys Ala Gly 
    1445                 1450                 1455             


Gly Cys  Thr Gly Cys Thr Thr  Cys Ala Gly Gly Ala  Ala Cys Thr 
    1460                 1465                 1470             


Gly Cys  Thr Cys Gly Ala Gly  Cys Cys Gly Cys Gly  Thr Cys Ala 
    1475                 1480                 1485             


Gly Gly  Ala Ala Ala Ala Gly  Cys Ala Ala Gly Ala  Gly Cys Thr 
    1490                 1495                 1500             


Gly Cys  Cys Thr Cys Ala Gly  Gly Cys Cys Gly Cys  Ala Thr Ala 
    1505                 1510                 1515             


Ala Gly  Gly Cys Ala Gly Cys  Thr Ala Ala Cys Thr  Cys Thr Cys 
    1520                 1525                 1530             


Gly Cys  Cys Gly Cys Cys Gly  Ala Cys Ala Ala Gly  Gly Gly Gly 
    1535                 1540                 1545             


Thr Ala  Cys Gly Ala Gly Gly  Thr Ala Gly Thr Cys  Gly Cys Gly 
    1550                 1555                 1560             


Ala Ala  Thr Cys Thr Gly Thr  Thr Thr Cys Ala Gly  Gly Thr Gly 
    1565                 1570                 1575             


Cys Cys  Cys Cys Ala Gly Ala  Ala Thr Cys Cys Thr  Gly Thr Ala 
    1580                 1585                 1590             


Gly Thr  Cys Gly Ala Cys Gly  Gly Gly Ala Thr Thr  Cys Thr Cys 
    1595                 1600                 1605             


Gly Cys  Thr Thr Cys Ala Cys  Cys Thr Gly Gly Gly  Ala Thr Ala 
    1610                 1615                 1620             


Cys Thr  Cys Cys Gly Cys Gly  Gly Thr Gly Cys Ala  Cys Ala Cys 
    1625                 1630                 1635             


Ala Ala  Cys Cys Thr Cys Gly  Ala Cys Thr Gly Cys  Gly Thr Gly 
    1640                 1645                 1650             


Thr Thr  Gly Ala Gly Ala Gly  Ala Gly Gly Gly Thr  Gly Cys Cys 
    1655                 1660                 1665             


Ala Cys  Gly Cys Thr Ala Thr  Thr Cys Cys Cys Thr  Gly Thr Gly 
    1670                 1675                 1680             


Gly Thr  Cys Ala Thr Cys Ala  Cys Gly Ala Cys Ala  Gly Thr Gly 
    1685                 1690                 1695             


Gly Ala  Ala Gly Ala Thr Gly  Cys Cys Ala Thr Gly  Ala Cys Ala 
    1700                 1705                 1710             


Cys Cys  Cys Ala Ala Ala Gly  Cys Ala Thr Thr Gly  Ala Ala Cys 
    1715                 1720                 1725             


Ala Gly  Cys Ala Ala Ala Ala  Thr Gly Thr Thr Thr  Gly Cys Thr 
    1730                 1735                 1740             


Gly Thr  Cys Ala Thr Thr Gly  Ala Ala Gly Gly Cys  Gly Thr Gly 
    1745                 1750                 1755             


Cys Gly  Ala Gly Ala Ala Gly  Ala Thr Cys Thr Ala  Cys Ala Ala 
    1760                 1765                 1770             


Cys Cys  Thr Cys Cys Ala Thr  Cys Thr Cys Ala Ala  Ala Gly Ala 
    1775                 1780                 1785             


Gly Gly  Ala Thr Cys Cys Thr  Thr Cys Ala Thr Ala  Cys Gly Ala 
    1790                 1795                 1800             


Ala Cys  Thr Cys Thr Cys Thr  Cys Cys Gly Cys Ala  Cys Ala Thr 
    1805                 1810                 1815             


Ala Gly  Ala Gly Thr Cys Thr  Ala Thr Gly Gly Ala  Thr Ala Thr 
    1820                 1825                 1830             


Gly Cys  Thr Cys Cys Ala Gly  Ala Thr Gly Gly Gly  Gly Thr Ala 
    1835                 1840                 1845             


Cys Thr  Thr Cys Cys Ala Cys  Thr Gly Gly Ala Gly  Ala Cys Thr 
    1850                 1855                 1860             


Gly Gly  Gly Ala Gly Ala Gly  Ala Thr Thr Ala Cys  Ala Cys Cys 
    1865                 1870                 1875             


Gly Thr  Gly Gly Thr Cys Cys  Cys Ala Ala Thr Ala  Gly Ala Thr 
    1880                 1885                 1890             


Gly Ala  Thr Gly Thr Cys Thr  Gly Gly Gly Ala Thr  Gly Ala Cys 
    1895                 1900                 1905             


Ala Gly  Cys Ala Thr Thr Ala  Thr Gly Cys Thr Gly  Thr Cys Cys 
    1910                 1915                 1920             


Ala Ala  Ala Gly Ala Cys Cys  Cys Cys Ala Thr Ala  Cys Cys Thr 
    1925                 1930                 1935             


Cys Cys  Thr Ala Thr Thr Gly  Thr Gly Gly Gly Ala  Ala Ala Cys 
    1940                 1945                 1950             


Ala Gly  Thr Ala Gly Ala Ala  Ala Cys Cys Thr Ala  Gly Ala Cys 
    1955                 1960                 1965             


Ala Thr  Ala Gly Cys Thr Thr  Ala Cys Ala Thr Gly  Gly Ala Thr 
    1970                 1975                 1980             


Gly Thr  Gly Thr Thr Thr Cys  Gly Ala Cys Cys Cys  Ala Ala Ala 
    1985                 1990                 1995             


Gly Thr  Cys Cys Cys Cys Ala  Thr Cys Cys Ala Thr  Gly Thr Gly 
    2000                 2005                 2010             


Gly Cys  Cys Ala Thr Gly Ala  Cys Gly Gly Gly Ala  Gly Cys Cys 
    2015                 2020                 2025             


Cys Thr  Cys Ala Ala Thr Gly  Cys Cys Thr Ala Thr  Gly Gly Cys 
    2030                 2035                 2040             


Gly Ala  Gly Ala Thr Thr Gly  Ala Gly Ala Ala Cys  Gly Thr Gly 
    2045                 2050                 2055             


Ala Gly  Cys Thr Thr Thr Ala  Gly Ala Ala Gly Cys  Ala Cys Cys 
    2060                 2065                 2070             


Ala Ala  Gly Cys Thr Cys Gly  Cys Cys Ala Cys Thr  Gly Cys Ala 
    2075                 2080                 2085             


Cys Ala  Cys Cys Gly Ala Cys  Thr Thr Gly Gly Cys  Cys Thr Cys 
    2090                 2095                 2100             


Ala Ala  Gly Thr Thr Gly Gly  Cys Thr Gly Gly Thr  Cys Cys Cys 
    2105                 2110                 2115             


Gly Gly  Thr Gly Cys Ala Thr  Thr Thr Gly Ala Cys  Gly Thr Gly 
    2120                 2125                 2130             


Ala Ala  Cys Ala Cys Cys Gly  Gly Gly Thr Cys Cys  Ala Ala Cys 
    2135                 2140                 2145             


Thr Gly  Gly Gly Cys Ala Ala  Cys Gly Thr Thr Cys  Ala Thr Cys 
    2150                 2155                 2160             


Ala Ala  Ala Cys Gly Thr Thr  Thr Cys Cys Cys Thr  Cys Ala Cys 
    2165                 2170                 2175             


Ala Ala  Thr Cys Cys Ala Cys  Gly Ala Gly Ala Cys  Thr Gly Gly 
    2180                 2185                 2190             


Gly Ala  Cys Ala Gly Gly Cys  Thr Cys Cys Cys Thr  Thr Ala Cys 
    2195                 2200                 2205             


Cys Thr  Cys Ala Ala Cys Cys  Thr Thr Cys Cys Ala  Thr Ala Cys 
    2210                 2215                 2220             


Cys Thr  Thr Cys Cys Ala Cys  Cys Cys Ala Ala Thr  Gly Cys Ala 
    2225                 2230                 2235             


Gly Gly  Ala Cys Gly Cys Cys  Ala Gly Thr Ala Cys  Gly Ala Cys 
    2240                 2245                 2250             


Cys Thr  Gly Gly Cys Cys Ala  Thr Gly Gly Cys Thr  Gly Cys Thr 
    2255                 2260                 2265             


Thr Cys  Ala Gly Ala Gly Thr  Thr Cys Ala Ala Ala  Gly Ala Gly 
    2270                 2275                 2280             


Ala Cys  Cys Cys Cys Cys Gly  Ala Ala Cys Thr Cys  Gly Ala Gly 
    2285                 2290                 2295             


Ala Gly  Cys Gly Cys Cys Gly  Thr Cys Ala Gly Ala  Gly Cys Cys 
    2300                 2305                 2310             


Ala Thr  Gly Gly Ala Ala Gly  Cys Ala Gly Ala Ala  Gly Cys Cys 
    2315                 2320                 2325             


Ala Ala  Cys Gly Thr Gly Gly  Ala Cys Cys Cys Ala  Cys Thr Gly 
    2330                 2335                 2340             


Thr Thr  Cys Cys Ala Ala Thr  Cys Thr Gly Cys Ala  Cys Thr Cys 
    2345                 2350                 2355             


Ala Gly  Cys Gly Thr Gly Thr  Thr Cys Ala Thr Gly  Thr Gly Gly 
    2360                 2365                 2370             


Cys Thr  Gly Gly Ala Ala Gly  Ala Gly Ala Ala Thr  Gly Gly Gly 
    2375                 2380                 2385             


Ala Thr  Thr Gly Thr Gly Ala  Cys Thr Gly Ala Thr  Ala Thr Gly 
    2390                 2395                 2400             


Gly Cys  Cys Ala Ala Cys Thr  Thr Cys Gly Cys Ala  Cys Thr Cys 
    2405                 2410                 2415             


Ala Gly  Cys Gly Ala Cys Cys  Cys Gly Ala Ala Thr  Gly Cys Cys 
    2420                 2425                 2430             


Cys Ala  Thr Cys Gly Gly Ala  Thr Gly Cys Gly Cys  Ala Ala Thr 
    2435                 2440                 2445             


Thr Thr  Thr Cys Thr Cys Gly  Cys Ala Ala Ala Cys  Gly Cys Ala 
    2450                 2455                 2460             


Cys Cys  Ala Cys Ala Ala Gly  Cys Ala Gly Gly Cys  Ala Gly Cys 
    2465                 2470                 2475             


Ala Ala  Gly Thr Cys Gly Cys  Ala Ala Ala Gly Ala  Gly Cys Cys 
    2480                 2485                 2490             


Ala Ala  Gly Thr Ala Cys Gly  Gly Gly Ala Cys Ala  Gly Cys Ala 
    2495                 2500                 2505             


Gly Gly  Cys Thr Ala Cys Gly  Gly Ala Gly Thr Gly  Gly Ala Gly 
    2510                 2515                 2520             


Gly Cys  Cys Cys Gly Gly Gly  Gly Cys Cys Cys Cys  Ala Cys Thr 
    2525                 2530                 2535             


Cys Cys  Ala Gly Ala Gly Gly  Ala Ala Gly Cys Ala  Cys Ala Gly 
    2540                 2545                 2550             


Ala Gly  Gly Gly Ala Ala Ala  Ala Ala Gly Ala Cys  Ala Cys Ala 
    2555                 2560                 2565             


Cys Gly  Gly Ala Thr Cys Thr  Cys Ala Ala Ala Gly  Ala Ala Gly 
    2570                 2575                 2580             


Ala Thr  Gly Gly Ala Gly Ala  Cys Thr Ala Thr Gly  Gly Gly Cys 
    2585                 2590                 2595             


Ala Thr  Cys Thr Ala Cys Thr  Thr Thr Gly Cys Ala  Ala Cys Ala 
    2600                 2605                 2610             


Cys Cys  Ala Gly Ala Ala Thr  Gly Gly Gly Thr Ala  Gly Cys Ala 
    2615                 2620                 2625             


Cys Thr  Cys Ala Ala Thr Gly  Gly Gly Cys Ala Cys  Cys Gly Gly 
    2630                 2635                 2640             


Gly Gly  Gly Thr Cys Ala Ala  Gly Cys Cys Cys Cys  Gly Gly Cys 
    2645                 2650                 2655             


Cys Ala  Gly Cys Thr Ala Ala  Ala Gly Thr Ala Cys  Thr Gly Gly 
    2660                 2665                 2670             


Cys Ala  Gly Ala Ala Cys Ala  Cys Ala Cys Gly Ala  Gly Ala Ala 
    2675                 2680                 2685             


Ala Thr  Ala Cys Cys Thr Gly  Ala Thr Cys Cys Ala  Ala Ala Cys 
    2690                 2695                 2700             


Gly Ala  Gly Gly Ala Cys Thr  Ala Cys Cys Thr Ala  Gly Ala Cys 
    2705                 2710                 2715             


Thr Ala  Cys Gly Thr Gly Cys  Ala Thr Gly Cys Ala  Gly Ala Gly 
    2720                 2725                 2730             


Ala Ala  Gly Ala Gly Cys Cys  Gly Gly Thr Thr Gly  Gly Cys Ala 
    2735                 2740                 2745             


Thr Cys  Ala Gly Ala Ala Gly  Ala Ala Cys Ala Ala  Ala Thr Cys 
    2750                 2755                 2760             


Cys Thr  Ala Ala Gly Gly Gly  Cys Ala Gly Cys Cys  Ala Cys Gly 
    2765                 2770                 2775             


Thr Cys  Gly Ala Thr Cys Thr  Ala Cys Gly Gly Gly  Gly Cys Thr 
    2780                 2785                 2790             


Cys Cys  Ala Gly Gly Ala Cys  Ala Gly Gly Cys Thr  Gly Ala Gly 
    2795                 2800                 2805             


Cys Cys  Ala Cys Cys Cys Cys  Ala Gly Gly Cys Cys  Thr Thr Cys 
    2810                 2815                 2820             


Ala Thr  Ala Gly Ala Cys Gly  Ala Ala Gly Thr Cys  Gly Cys Cys 
    2825                 2830                 2835             


Ala Ala  Ala Gly Thr Cys Thr  Ala Thr Gly Ala Ala  Ala Thr Cys 
    2840                 2845                 2850             


Ala Ala  Cys Cys Ala Thr Gly  Gly Gly Cys Gly Thr  Gly Gly Cys 
    2855                 2860                 2865             


Cys Cys  Cys Ala Ala Cys Cys  Ala Ala Gly Ala Ala  Cys Ala Gly 
    2870                 2875                 2880             


Ala Thr  Gly Ala Ala Ala Gly  Ala Thr Cys Thr Gly  Cys Thr Cys 
    2885                 2890                 2895             


Thr Thr  Gly Ala Cys Thr Gly  Cys Gly Ala Thr Gly  Gly Ala Gly 
    2900                 2905                 2910             


Ala Thr  Gly Ala Ala Gly Cys  Ala Thr Cys Gly Cys  Ala Ala Thr 
    2915                 2920                 2925             


Cys Cys  Cys Ala Gly Gly Cys  Gly Gly Gly Cys Thr  Cys Cys Ala 
    2930                 2935                 2940             


Cys Cys  Ala Ala Ala Gly Cys  Cys Cys Ala Ala Gly  Cys Cys Ala 
    2945                 2950                 2955             


Ala Ala  Ala Cys Cys Cys Ala  Ala Thr Gly Thr Thr  Cys Cys Ala 
    2960                 2965                 2970             


Ala Cys  Ala Cys Ala Gly Ala  Gly Ala Cys Cys Cys  Cys Cys Thr 
    2975                 2980                 2985             


Gly Gly  Thr Cys Gly Gly Cys  Thr Gly Gly Gly Cys  Cys Gly Cys 
    2990                 2995                 3000             


Thr Gly  Gly Ala Thr Cys Ala  Gly Gly Gly Cys Thr  Gly Thr Cys 
    3005                 3010                 3015             


Thr Cys  Thr Gly Ala Thr Gly  Ala Gly Gly Ala Cys  Cys Thr Thr 
    3020                 3025                 3030             


Gly Ala  Gly Thr Gly Ala 
    3035                 


<210>  34
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  Infectious bursal disease virus viral protein 2, viral protein 4 
       and viral protein 3 of segment A (VP2-VP4-VP3), amino acid 
       sequence

<400>  34

Met Thr Asn Leu Gln Asp Gln Thr Gln Gln Ile Val Pro Phe Ile Arg 
1               5                   10                  15      


Ser Leu Leu Met Pro Thr Thr Gly Pro Ala Ser Ile Pro Asp Asp Thr 
            20                  25                  30          


Leu Glu Lys His Thr Leu Arg Ser Glu Thr Ser Thr Tyr Asn Leu Thr 
        35                  40                  45              


Val Gly Asp Thr Gly Ser Gly Leu Ile Val Phe Phe Pro Gly Phe Pro 
    50                  55                  60                  


Gly Ser Ile Val Gly Ala His Tyr Thr Leu Gln Ser Asn Gly Asn Tyr 
65                  70                  75                  80  


Lys Phe Asp Gln Met Leu Leu Thr Ala Gln Asn Leu Pro Ala Ser Tyr 
                85                  90                  95      


Asn Tyr Cys Arg Leu Val Ser Arg Ser Leu Thr Val Arg Ser Ser Thr 
            100                 105                 110         


Leu Pro Gly Gly Val Tyr Ala Leu Asn Gly Thr Ile Asn Ala Val Thr 
        115                 120                 125             


Phe Gln Gly Ser Leu Ser Glu Leu Thr Asp Val Ser Tyr Asn Gly Leu 
    130                 135                 140                 


Met Ser Ala Thr Ala Asn Ile Asn Asp Lys Ile Gly Asn Val Leu Val 
145                 150                 155                 160 


Gly Glu Gly Val Thr Val Leu Ser Leu Pro Thr Ser Tyr Asp Leu Gly 
                165                 170                 175     


Tyr Val Arg Leu Gly Asp Pro Ile Pro Ala Ile Gly Leu Asp Pro Lys 
            180                 185                 190         


Met Val Ala Thr Cys Asp Ser Ser Asp Arg Pro Arg Val Tyr Thr Ile 
        195                 200                 205             


Thr Ala Ala Asp Asp Tyr Gln Phe Ser Ser Gln Tyr Gln Ala Gly Gly 
    210                 215                 220                 


Val Thr Ile Thr Leu Phe Ser Ala Asn Ile Asp Ala Ile Thr Ser Leu 
225                 230                 235                 240 


Ser Ile Gly Gly Glu Leu Val Phe Gln Thr Ser Val Gln Gly Leu Ile 
                245                 250                 255     


Leu Gly Ala Thr Ile Tyr Leu Ile Gly Phe Asp Gly Thr Ala Val Ile 
            260                 265                 270         


Thr Arg Ala Val Ala Ala Asn Asn Gly Leu Thr Ala Gly Thr Asp Asn 
        275                 280                 285             


Leu Met Pro Phe Asn Ile Val Ile Pro Thr Ser Glu Ile Thr Gln Pro 
    290                 295                 300                 


Ile Thr Ser Ile Lys Leu Glu Ile Val Thr Ser Lys Ser Gly Gly Gln 
305                 310                 315                 320 


Ala Gly Asp Gln Met Ser Trp Ser Ala Ser Gly Ser Leu Ala Val Thr 
                325                 330                 335     


Ile His Gly Gly Asn Tyr Pro Gly Ala Leu Arg Pro Val Thr Leu Val 
            340                 345                 350         


Ala Tyr Glu Arg Val Ala Thr Gly Ser Val Val Thr Val Ala Gly Val 
        355                 360                 365             


Ser Asn Phe Glu Leu Ile Pro Asn Pro Glu Leu Ala Lys Asn Leu Val 
    370                 375                 380                 


Thr Glu Tyr Gly Arg Phe Asp Pro Gly Ala Met Asn Tyr Thr Lys Leu 
385                 390                 395                 400 


Ile Leu Ser Glu Arg Asp Arg Leu Gly Ile Lys Thr Val Trp Pro Thr 
                405                 410                 415     


Arg Glu Tyr Thr Asp Phe Arg Glu Tyr Phe Met Glu Val Ala Asp Leu 
            420                 425                 430         


Asn Ser Pro Leu Lys Ile Ala Gly Ala Phe Gly Phe Lys Asp Ile Ile 
        435                 440                 445             


Arg Ala Leu Arg Arg Ile Ala Val Pro Val Val Ser Thr Leu Phe Pro 
    450                 455                 460                 


Pro Ala Ala Pro Leu 
465                 


<210>  35
<211>  1707
<212>  DNA
<213>  Artificial

<220>
<223>  Influenza A virus (A/chicken/Israel/215/2007(H9N2)) segment 4 
       hemagglutinin (HA); Reference: GenBank: FJ464716.1, DNA sequence

<400>  35
atggaaataa tatcactgat gactatacta ctagtagtaa caacaagcaa tgcagataaa       60

atatgcattg gccaccagtc aacaaattcc acagaaactg tggatacact aacagaaact      120

aatgttcctg tgacacatgc caaagaattg ctccacacag agcacaatgg aatgctgtgt      180

gcaacaaatc tgggaaatcc cctcatccta gacacatgca ctatcgaagg acttatctat      240

ggtaaccctt cttgtgacat gttgttgggg ggaagggaat ggtcctacat cgttgaaaga      300

ccatcagcgg taaatggaac atgttaccct gggaatgtgg aaaacttaga ggaactcaga      360

acacttttta gttcctctag ttcctatcaa agaatccaaa tattcccaga cacaatctgg      420

aatgtgactt acaatggaac aagcaaatca tgttcaaatt cattctacag gaatatgaga      480

tggctaactc aaaagaacgg ggtttatcct gttcaagacg cccaatacac aaataatcgg      540

ggaaaggaca ttcttttcgt gtggggcata catcatccac ccaccgatac tgcacagacg      600

aatttgtaca caagaaccga cacaacaaca agcgtaacaa cagaaaattt agataggacc      660

ttcaaaccat tgatagggcc aaggcccctt gtcaatggtc tgattggaag aattaattat      720

tattggtcgg tactaaaacc aggccagaca ttgcgagtaa gatccaatgg gaatctaatt      780

gctccatggt ttggacacgt tctctcagga gagagccatg ggagaatcct gaaaactgat      840

ttaaacagtg gtaattgtgt agtgcaatgt cagactgaaa aaggtggcct aaacagtaca      900

ttgcctttcc acaatatcag taaatatgca tttgggaatt gccccaaata tattggagtc      960

aagagtctca aactggcaat cggtctgaga aacgtgcctg ccaggtcaag tagaggacta     1020

tttggagcca tagctggatt catagaagga ggttggccag ggctagtcgc cggttggtat     1080

ggtttccagc attcaaatga tcaaggggtt ggtatggctg cagataggga ttcaactcaa     1140

aaggcagttg acaaaataac atccaaggtg aataatatag tcgacaagat gaacaagcaa     1200

tatgaaataa ttgatcatga attcagtgag gttgaaacta gactcaatat gatcaataac     1260

aagattgatg accaaataca agatgtatgg gcatataatg cagagttgct agtactactt     1320

gagaaccaga aaacactcga tgagcatgac gcaaacgtga acaacctata taacaaggtg     1380

aaaagggcct tgggctccaa tgcgatggaa gatgggaagg gctgtttcga gctataccac     1440

aaatgtgatg accaatgcat ggaaactatt cggaacggga cctataatag gagaaagtac     1500

aaagaggaat caagactaga aaggcagaaa atagagggag tcaaactgga atctgagggg     1560

atttacaaaa tacttaccat ttattcgact gtcgcctcat ctcttgtact tgcaatgggg     1620

tttgctgcct tcttattctg ggccatgtcc aatggatcat gcaggtgcaa catctgtata     1680

taattagcaa aaacaccctt gtttcta                                         1707


<210>  36
<211>  560
<212>  PRT
<213>  Artificial

<220>
<223>  Influenza A virus (A/chicken/Israel/215/2007(H9N2)) segment 4 
       hemagglutinin (HA); Reference: GenBank: FJ464716.1, Amino acid 
       sequence

<400>  36

Met Glu Ile Ile Ser Leu Met Thr Ile Leu Leu Val Val Thr Thr Ser 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Ile Gly His Gln Ser Thr Asn Ser Thr Glu 
            20                  25                  30          


Thr Val Asp Thr Leu Thr Glu Thr Asn Val Pro Val Thr His Ala Lys 
        35                  40                  45              


Glu Leu Leu His Thr Glu His Asn Gly Met Leu Cys Ala Thr Asn Leu 
    50                  55                  60                  


Gly Asn Pro Leu Ile Leu Asp Thr Cys Thr Ile Glu Gly Leu Ile Tyr 
65                  70                  75                  80  


Gly Asn Pro Ser Cys Asp Met Leu Leu Gly Gly Arg Glu Trp Ser Tyr 
                85                  90                  95      


Ile Val Glu Arg Pro Ser Ala Val Asn Gly Thr Cys Tyr Pro Gly Asn 
            100                 105                 110         


Val Glu Asn Leu Glu Glu Leu Arg Thr Leu Phe Ser Ser Ser Ser Ser 
        115                 120                 125             


Tyr Gln Arg Ile Gln Ile Phe Pro Asp Thr Ile Trp Asn Val Thr Tyr 
    130                 135                 140                 


Asn Gly Thr Ser Lys Ser Cys Ser Asn Ser Phe Tyr Arg Asn Met Arg 
145                 150                 155                 160 


Trp Leu Thr Gln Lys Asn Gly Val Tyr Pro Val Gln Asp Ala Gln Tyr 
                165                 170                 175     


Thr Asn Asn Arg Gly Lys Asp Ile Leu Phe Val Trp Gly Ile His His 
            180                 185                 190         


Pro Pro Thr Asp Thr Ala Gln Thr Asn Leu Tyr Thr Arg Thr Asp Thr 
        195                 200                 205             


Thr Thr Ser Val Thr Thr Glu Asn Leu Asp Arg Thr Phe Lys Pro Leu 
    210                 215                 220                 


Ile Gly Pro Arg Pro Leu Val Asn Gly Leu Ile Gly Arg Ile Asn Tyr 
225                 230                 235                 240 


Tyr Trp Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Val Arg Ser Asn 
                245                 250                 255     


Gly Asn Leu Ile Ala Pro Trp Phe Gly His Val Leu Ser Gly Glu Ser 
            260                 265                 270         


His Gly Arg Ile Leu Lys Thr Asp Leu Asn Ser Gly Asn Cys Val Val 
        275                 280                 285             


Gln Cys Gln Thr Glu Lys Gly Gly Leu Asn Ser Thr Leu Pro Phe His 
    290                 295                 300                 


Asn Ile Ser Lys Tyr Ala Phe Gly Asn Cys Pro Lys Tyr Ile Gly Val 
305                 310                 315                 320 


Lys Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val Pro Ala Arg Ser 
                325                 330                 335     


Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
            340                 345                 350         


Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln 
        355                 360                 365             


Gly Val Gly Met Ala Ala Asp Arg Asp Ser Thr Gln Lys Ala Val Asp 
    370                 375                 380                 


Lys Ile Thr Ser Lys Val Asn Asn Ile Val Asp Lys Met Asn Lys Gln 
385                 390                 395                 400 


Tyr Glu Ile Ile Asp His Glu Phe Ser Glu Val Glu Thr Arg Leu Asn 
                405                 410                 415     


Met Ile Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Val Trp Ala Tyr 
            420                 425                 430         


Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu 
        435                 440                 445             


His Asp Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu 
    450                 455                 460                 


Gly Ser Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His 
465                 470                 475                 480 


Lys Cys Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn 
                485                 490                 495     


Arg Arg Lys Tyr Lys Glu Glu Ser Arg Leu Glu Arg Gln Lys Ile Glu 
            500                 505                 510         


Gly Val Lys Leu Glu Ser Glu Gly Ile Tyr Lys Ile Leu Thr Ile Tyr 
        515                 520                 525             


Ser Thr Val Ala Ser Ser Leu Val Leu Ala Met Gly Phe Ala Ala Phe 
    530                 535                 540                 


Leu Phe Trp Ala Met Ser Asn Gly Ser Cys Arg Cys Asn Ile Cys Ile 
545                 550                 555                 560 


<210>  37
<211>  1617
<212>  DNA
<213>  Artificial

<220>
<223>  Avian infectious bronchitis virus isolate variant 1 S1 spike 
       glycoprotein gene, Reference: GenBank: AF093795.1; DNA sequence

<400>  37
atgttgggca aaccgctttt actagtgact ctttggtatg cactatgtag tgctttgctc       60

tatgatagta gtacttacgt ttactactac caaagtgctt ttaggcctag ttcaggttgg      120

cacatacatg ggggtgctta tgcagtagat agggttttta atgaaaccaa caatgcaggc      180

agtgtatctg attgcactgc tggtactttt tatgaaagcc ataatatttc tgctgtttct      240

gtagccatga cagcaccaca taatggtatg tcttggtcag tttcacaatt ttgtacagct      300

cattgtaact tctcagactt tacagtgttc gttacgcatt gttttaaaaa tcaacctggt      360

agttgtccct tgacaggtat gattcctcag aatcatattc gtatttctgc tatgagacaa      420

ggaactttgt tttataactt aacagttagt gtgtctaaat atcctagatt taaatcgctt      480

caatgtgtta gcaattctac atctgtctat gtaaatggtg atcttgtttt cacttctaat      540

gaaacttctt acattacggg tgcaggcgtt tattttaaaa gtggtgggcc tgtaacttat      600

aaagttatga aagaagttaa agccctagcc tactttatta atggtaccgc acaagaggtt      660

attttatgtg ataactcacc tagaggtttg cttgcatgtc agtataatac tggtaatttt      720

tcagatggat tctacccttt tactaatcat tctttagtta aggataggtt tattgtatat      780

cgagaaagtg gcactaacac tactttaaag ttaactaatt tcagttttac taatgtaagt      840

aatgctcctc ctaattcagg tggcgttgat actttccaat tatatcaaac acatactgct      900

caggatggtt attataattt taatttatca tttctgagta gttttgtgta taaaccatct      960

gattttatgt atgggtcata ccacccacat tgtaatttta gaccagaaaa tattaataat     1020

ggcttatggt ttaattcatt atctgtgtca cttacttacg gacccattca aggtggttgt     1080

aagcaatctg tttttaataa tagagcaact tgttgctatg cttattctta tcaagggcct     1140

agtttatgta agggtgttta tagaggggag ctaatgcaat actttgaatg tggacttcta     1200

gtttacgtaa ctaagagtga tggctctcgt atacaaacta gaagtgaacc acttgtgtta     1260

actcaatata attataacaa cattacttta aacaagtgtg ttgagtataa tatatatggt     1320

agagttggtc aaggtcttat tactaatgta actgaagcaa ctgctaatta tagttatcta     1380

gcagatggtg gtttagctat tttagatacc tcaggagcca tagacatatt tgttgttcaa     1440

ggtgcacatg gtcttaatta ttataaggtt aatccctgtg aggatgttaa ccaacagttt     1500

gtagtgtcag gtggcaactt agttggcatt cttacatctc ataatgaaac aggttctgaa     1560

tctattgaga accagtttta catcaaactc actaacggaa cacgtcgctc tagacgt        1617


<210>  38
<211>  539
<212>  PRT
<213>  Artificial

<220>
<223>  Avian infectious bronchitis virus isolate variant 1 S1 spike 
       glycoprotein gene, Reference: GenBank: AF093795.1; Amino acid 
       sequence

<400>  38

Met Leu Gly Lys Pro Leu Leu Leu Val Thr Leu Trp Tyr Ala Leu Cys 
1               5                   10                  15      


Ser Ala Leu Leu Tyr Asp Ser Ser Thr Tyr Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Ser Ser Gly Trp His Ile His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Asp Arg Val Phe Asn Glu Thr Asn Asn Ala Gly Ser Val Ser Asp 
    50                  55                  60                  


Cys Thr Ala Gly Thr Phe Tyr Glu Ser His Asn Ile Ser Ala Val Ser 
65                  70                  75                  80  


Val Ala Met Thr Ala Pro His Asn Gly Met Ser Trp Ser Val Ser Gln 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Ser Asp Phe Thr Val Phe Val Thr 
            100                 105                 110         


His Cys Phe Lys Asn Gln Pro Gly Ser Cys Pro Leu Thr Gly Met Ile 
        115                 120                 125             


Pro Gln Asn His Ile Arg Ile Ser Ala Met Arg Gln Gly Thr Leu Phe 
    130                 135                 140                 


Tyr Asn Leu Thr Val Ser Val Ser Lys Tyr Pro Arg Phe Lys Ser Leu 
145                 150                 155                 160 


Gln Cys Val Ser Asn Ser Thr Ser Val Tyr Val Asn Gly Asp Leu Val 
                165                 170                 175     


Phe Thr Ser Asn Glu Thr Ser Tyr Ile Thr Gly Ala Gly Val Tyr Phe 
            180                 185                 190         


Lys Ser Gly Gly Pro Val Thr Tyr Lys Val Met Lys Glu Val Lys Ala 
        195                 200                 205             


Leu Ala Tyr Phe Ile Asn Gly Thr Ala Gln Glu Val Ile Leu Cys Asp 
    210                 215                 220                 


Asn Ser Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn Phe 
225                 230                 235                 240 


Ser Asp Gly Phe Tyr Pro Phe Thr Asn His Ser Leu Val Lys Asp Arg 
                245                 250                 255     


Phe Ile Val Tyr Arg Glu Ser Gly Thr Asn Thr Thr Leu Lys Leu Thr 
            260                 265                 270         


Asn Phe Ser Phe Thr Asn Val Ser Asn Ala Pro Pro Asn Ser Gly Gly 
        275                 280                 285             


Val Asp Thr Phe Gln Leu Tyr Gln Thr His Thr Ala Gln Asp Gly Tyr 
    290                 295                 300                 


Tyr Asn Phe Asn Leu Ser Phe Leu Ser Ser Phe Val Tyr Lys Pro Ser 
305                 310                 315                 320 


Asp Phe Met Tyr Gly Ser Tyr His Pro His Cys Asn Phe Arg Pro Glu 
                325                 330                 335     


Asn Ile Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Leu Thr 
            340                 345                 350         


Tyr Gly Pro Ile Gln Gly Gly Cys Lys Gln Ser Val Phe Asn Asn Arg 
        355                 360                 365             


Ala Thr Cys Cys Tyr Ala Tyr Ser Tyr Gln Gly Pro Ser Leu Cys Lys 
    370                 375                 380                 


Gly Val Tyr Arg Gly Glu Leu Met Gln Tyr Phe Glu Cys Gly Leu Leu 
385                 390                 395                 400 


Val Tyr Val Thr Lys Ser Asp Gly Ser Arg Ile Gln Thr Arg Ser Glu 
                405                 410                 415     


Pro Leu Val Leu Thr Gln Tyr Asn Tyr Asn Asn Ile Thr Leu Asn Lys 
            420                 425                 430         


Cys Val Glu Tyr Asn Ile Tyr Gly Arg Val Gly Gln Gly Leu Ile Thr 
        435                 440                 445             


Asn Val Thr Glu Ala Thr Ala Asn Tyr Ser Tyr Leu Ala Asp Gly Gly 
    450                 455                 460                 


Leu Ala Ile Leu Asp Thr Ser Gly Ala Ile Asp Ile Phe Val Val Gln 
465                 470                 475                 480 


Gly Ala His Gly Leu Asn Tyr Tyr Lys Val Asn Pro Cys Glu Asp Val 
                485                 490                 495     


Asn Gln Gln Phe Val Val Ser Gly Gly Asn Leu Val Gly Ile Leu Thr 
            500                 505                 510         


Ser His Asn Glu Thr Gly Ser Glu Ser Ile Glu Asn Gln Phe Tyr Ile 
        515                 520                 525             


Lys Leu Thr Asn Gly Thr Arg Arg Ser Arg Arg 
    530                 535                 


<210>  39
<211>  1754
<212>  DNA
<213>  Artificial

<220>
<223>  Eimeria maxima 56 kDa gametocyte antigen (gam56) Reference: 
       GenBank: AY129951.2; DNA sequence

<400>  39
agcagaacat agggagttca tctgttcctt cttttcatca tttattcctc gtttctcacc       60

gttttatttt ttttgtgtaa ccctctccgc tgttgagtcc caatgacccg cctcggcctc      120

gctgctgtcg cgctggctct cgccgtgggc ccttccatgg cagtgcccag caccactcct      180

gttgagaacc aggttcaccc ttacagcgag atgagtacct accaggaggg gagtgccccg      240

ggggctccgg aggacaccac caccaccact acgtcgtccc ctgtttccga tggagccgag      300

cagtggcttg agagctttgt tcgtgctgtg cagcgccagc tgcagcttca ggaccaaatg      360

atgcgtcagc tcatgaggga cattcaggag tacctgagca ctgcgttcaa ctgggcagag      420

aaccagtcta ctgcctacac ccgtgttacc gagatgatgg acatgatctc caacagaatg      480

aacgctgcca tggacagctc aaacgaactc atgaccacta gcgacaccac agaccccgag      540

accctccgcc gtgcaactcg caagtacatg aaggaggttc gcgttcagga cgtcctggta      600

gatgctctct gggcctctct ccgcggtgta cagacagctg cctggatgaa tggagtgacc      660

gctattgaga aggaggagac gactcccatg gctagccgcg ctgctgagga gttcctccac      720

cgcatgtacc ataacctgag ggcagcaggt atgtctgaag aagatgttgc caagttcatc      780

cctagagccg agtacaaccc ctccgagcag tcaagaaata tgggcagaaa gggcaggagc      840

ttctactacg gcggctatcc cagctactac aactccccct actacagcta cagcagctac      900

cccagctact acaactacag ctacccgtca tacagctaca gcagctaccc cagctactac      960

cgctacagca gctaccccta ctacaactac agctatccca gctactacaa ctacggcagc     1020

tacccctact acagttatag cagctacccc agctggtact ggcgccgtct ccgctctttg     1080

gcaacagcaa cttgcccaga ctgccctcct ctcaccactc ccagcatgat cccaactccc     1140

cccccaatga tgaacatgat gaacacccca ccccccatgg caaacatgat gaccagcatg     1200

atgatgaaca ctcccatggt tcctcctccc cgcaccctcg gaactgaagc catgagcctc     1260

ggcttggccc ccatcggtat caccggcgcc cccatgacag gtttcggtgt tcctcctgag     1320

ttcggtccct ttggagccga aggtatcggc ctccccaccg atgccctcgg cagcaccccc     1380

gaaatgacac cattcgaccc aactaccccc tacagaactc tcgcccccat ggacctcccc     1440

cccatccccc ctcctgtctt ccctgaaacc cctatgaggc cacctactcc cttcggcttc     1500

ggacctgcac ctgttcctcc catgcccttc taaacgacct accatccctc aatccatagc     1560

tcacatttcg tagcctcaaa acagtttttt gttcatttca cttccaggac tcatgctgcg     1620

acatttgcat tcgtacctcg aaaccgtcaa cctcaaaccc caaaccattc tgtgacctcc     1680

cctcgcaaac gcggaaggcg gaacattttt tctgaagtat attactacgt taaaaaaaaa     1740

aaaaaaaaaa aaaa                                                       1754


<210>  40
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Eimeria maxima 56 kDa gametocyte antigen (gam56) Reference: 
       GenBank: AY129951.2; Amino acid sequence

<400>  40

Met Thr Arg Leu Gly Leu Ala Ala Val Ala Leu Ala Leu Ala Val Gly 
1               5                   10                  15      


Pro Ser Met Ala Val Pro Ser Thr Thr Pro Val Glu Asn Gln Val His 
            20                  25                  30          


Pro Tyr Ser Glu Met Ser Thr Tyr Gln Glu Gly Ser Ala Pro Gly Ala 
        35                  40                  45              


Pro Glu Asp Thr Thr Thr Thr Thr Thr Ser Ser Pro Val Ser Asp Gly 
    50                  55                  60                  


Ala Glu Gln Trp Leu Glu Ser Phe Val Arg Ala Val Gln Arg Gln Leu 
65                  70                  75                  80  


Gln Leu Gln Asp Gln Met Met Arg Gln Leu Met Arg Asp Ile Gln Glu 
                85                  90                  95      


Tyr Leu Ser Thr Ala Phe Asn Trp Ala Glu Asn Gln Ser Thr Ala Tyr 
            100                 105                 110         


Thr Arg Val Thr Glu Met Met Asp Met Ile Ser Asn Arg Met Asn Ala 
        115                 120                 125             


Ala Met Asp Ser Ser Asn Glu Leu Met Thr Thr Ser Asp Thr Thr Asp 
    130                 135                 140                 


Pro Glu Thr Leu Arg Arg Ala Thr Arg Lys Tyr Met Lys Glu Val Arg 
145                 150                 155                 160 


Val Gln Asp Val Leu Val Asp Ala Leu Trp Ala Ser Leu Arg Gly Val 
                165                 170                 175     


Gln Thr Ala Ala Trp Met Asn Gly Val Thr Ala Ile Glu Lys Glu Glu 
            180                 185                 190         


Thr Thr Pro Met Ala Ser Arg Ala Ala Glu Glu Phe Leu His Arg Met 
        195                 200                 205             


Tyr His Asn Leu Arg Ala Ala Gly Met Ser Glu Glu Asp Val Ala Lys 
    210                 215                 220                 


Phe Ile Pro Arg Ala Glu Tyr Asn Pro Ser Glu Gln Ser Arg Asn Met 
225                 230                 235                 240 


Gly Arg Lys Gly Arg Ser Phe Tyr Tyr Gly Gly Tyr Pro Ser Tyr Tyr 
                245                 250                 255     


Asn Ser Pro Tyr Tyr Ser Tyr Ser Ser Tyr Pro Ser Tyr Tyr Asn Tyr 
            260                 265                 270         


Ser Tyr Pro Ser Tyr Ser Tyr Ser Ser Tyr Pro Ser Tyr Tyr Arg Tyr 
        275                 280                 285             


Ser Ser Tyr Pro Tyr Tyr Asn Tyr Ser Tyr Pro Ser Tyr Tyr Asn Tyr 
    290                 295                 300                 


Gly Ser Tyr Pro Tyr Tyr Ser Tyr Ser Ser Tyr Pro Ser Trp Tyr Trp 
305                 310                 315                 320 


Arg Arg Leu Arg Ser Leu Ala Thr Ala Thr Cys Pro Asp Cys Pro Pro 
                325                 330                 335     


Leu Thr Thr Pro Ser Met Ile Pro Thr Pro Pro Pro Met Met Asn Met 
            340                 345                 350         


Met Asn Thr Pro Pro Pro Met Ala Asn Met Met Thr Ser Met Met Met 
        355                 360                 365             


Asn Thr Pro Met Val Pro Pro Pro Arg Thr Leu Gly Thr Glu Ala Met 
    370                 375                 380                 


Ser Leu Gly Leu Ala Pro Ile Gly Ile Thr Gly Ala Pro Met Thr Gly 
385                 390                 395                 400 


Phe Gly Val Pro Pro Glu Phe Gly Pro Phe Gly Ala Glu Gly Ile Gly 
                405                 410                 415     


Leu Pro Thr Asp Ala Leu Gly Ser Thr Pro Glu Met Thr Pro Phe Asp 
            420                 425                 430         


Pro Thr Thr Pro Tyr Arg Thr Leu Ala Pro Met Asp Leu Pro Pro Ile 
        435                 440                 445             


Pro Pro Pro Val Phe Pro Glu Thr Pro Met Arg Pro Pro Thr Pro Phe 
    450                 455                 460                 


Gly Phe Gly Pro Ala Pro Val Pro Pro Met Pro Phe 
465                 470                 475     


<210>  41
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  DNA primer

<400>  41
atcaggacag caaagacagc a                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  DNA primer

<400>  42
gcctcagtcg tgtgcttctt g                                                 21


