                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  GROWTH HORMONE COMPOUNDS

<130>  8615WO01

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  191
<212>  PRT
<213>  homo sapiens

<400>  1

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190     


<210>  2
<211>  620
<212>  PRT
<213>  homo sapiens

<400>  2

Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala Pro Trp 
1               5                   10                  15      


Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser Lys Glu 
            20                  25                  30          


Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe Ser Cys 
        35                  40                  45              


His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly Pro Ile 
    50                  55                  60                  


Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln Glu Trp 
65                  70                  75                  80  


Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys Tyr Phe 
                85                  90                  95      


Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys Leu Thr 
            100                 105                 110         


Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp Glu Ile 
        115                 120                 125             


Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu Asn Val 
    130                 135                 140                 


Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu Ala Pro 
145                 150                 155                 160 


Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr Glu Leu 
                165                 170                 175     


Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp Pro Ile 
            180                 185                 190         


Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys Glu Tyr 
        195                 200                 205             


Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr Gly Glu 
    210                 215                 220                 


Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Ser Gln Phe Thr 
225                 230                 235                 240 


Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile Phe Gly 
                245                 250                 255     


Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser Lys Gln 
            260                 265                 270         


Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro Lys Ile 
        275                 280                 285             


Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu Glu Val 
    290                 295                 300                 


Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe His Ser 
305                 310                 315                 320 


Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu Pro Asp 
                325                 330                 335     


Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser Asp His 
            340                 345                 350         


Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser Gly Arg 
        355                 360                 365             


Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn Ala Asn 
    370                 375                 380                 


Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg Leu Lys 
385                 390                 395                 400 


Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn Asn Ser 
                405                 410                 415     


Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val Ile Gln 
            420                 425                 430         


Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala Glu Ser 
        435                 440                 445             


Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser Leu Ser 
    450                 455                 460                 


Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala Gly Ser 
465                 470                 475                 480 


Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser Gln Cys 
                485                 490                 495     


Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe Leu Met 
            500                 505                 510         


Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile Pro Val 
        515                 520                 525             


Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu Asn Gln 
    530                 535                 540                 


Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala Gly Arg 
545                 550                 555                 560 


Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val Pro Asp 
                565                 570                 575     


Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile Leu Asn 
            580                 585                 590         


Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser Cys Gly 
        595                 600                 605             


Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
    610                 615                 620 


<210>  3
<211>  227
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  hinge region

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  225
<212>  PRT
<213>  Rattus rattus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  hinge region

<400>  4

Val Pro Arg Glu Cys Asn Pro Cys Gly Cys Thr Gly Ser Glu Val Ser 
1               5                   10                  15      


Ser Val Phe Ile Phe Pro Pro Lys Thr Lys Asp Val Leu Thr Ile Thr 
            20                  25                  30          


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Gln Asn Asp 
        35                  40                  45              


Pro Glu Val Arg Phe Ser Trp Phe Ile Asp Asp Val Glu Val His Thr 
    50                  55                  60                  


Ala Gln Thr His Ala Pro Glu Lys Gln Ser Asn Ser Thr Leu Arg Ser 
65                  70                  75                  80  


Val Ser Glu Leu Pro Ile Val His Arg Asp Trp Leu Asn Gly Lys Thr 
                85                  90                  95      


Phe Lys Cys Lys Val Asn Ser Gly Ala Phe Pro Ala Pro Ile Glu Lys 
            100                 105                 110         


Ser Ile Ser Lys Pro Glu Gly Thr Pro Arg Gly Pro Gln Val Tyr Thr 
        115                 120                 125             


Met Ala Pro Pro Lys Glu Glu Met Thr Gln Ser Gln Val Ser Ile Thr 
    130                 135                 140                 


Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile Tyr Thr Glu Trp Lys 
145                 150                 155                 160 


Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn Thr Pro Pro Thr Met 
                165                 170                 175     


Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Asn Val Lys Lys 
            180                 185                 190         


Glu Thr Trp Gln Gln Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
        195                 200                 205             


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  5
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30      


