                         SEQUENCE LISTING

<110>  Lonza Ltd.
 
<120>  CONSTITUTIVE PROMOTER

<130>  LO003P

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  985
<212>  DNA
<213>  Pichia pastoris

<400>  1
agggcatcat tgaggtttcc acaaaaggaa gaaacatgga tccagagaca tcaacagaga       60

ggaaagcggg tagtgaagcc gaagccacaa cacagcccga tttggaaggg agttcacaat      120

caaggtgagt ccagccattt tttttctttt tttttttttt attcaggtga acccacctaa      180

ctatttttaa ctgggatcca gtgagctcgc tgggtgaaag ccaaccatct tttgtttcgg      240

ggaaccgtgc tcgccccgta aagttaattt ttttttcccg cgcagcttta atctttcggc      300

agagaaggcg ttttcatcgt agcgtgggaa cagaataatc agttcatgtg ctatacaggc      360

acatggcagc agtcactatt ttgcttttta accttaaagt cgttcatcaa tcattaactg      420

accaatcaga ttttttgcat ttgccactta tctaaaaata cttttgtatc tcgcagatac      480

gttcagtggt ttccaggaca acacccaaaa aaaggtatca atgccactag gcagtcggtt      540

ttatttttgg tcacccacgc aaagaagcac ccacctcttt taggttttaa gttgtgggaa      600

cagtaacacc gcctagagct tcaggaaaaa ccagtacctg tgaccgcaat tcaccatgat      660

gcagaatgtt aatttaaacg agtgccaaat caagatttca acagacaaat caatcgatcc      720

atagttaccc attccagcct tttcgtcgtc gagcctgctt cattcctgcc tcaggtgcat      780

aactttgcat gaaaagtcca gattagggca gattttgagt ttaaaatagg aaatataaac      840

aaatataccg cgaaaaaggt ttgtttatag cttttcgcct ggtgccgtac ggtataaata      900

catactctcc tcccccccct ggttctcttt ttcttttgtt acttacattt taccgttccg      960

tcactcgctt cactcaacaa caaaa                                            985


<210>  2
<211>  1488
<212>  DNA
<213>  Pichia pastoris

<400>  2
gatagttcta gaagacctgg cgtcgctggt caactactcg tttcacaagt tgacaaagac       60

ttttaccaag agaagagcag ttgtcaccga ccacaataac aacctggaag ccgagaaaaa      120

acttggaatc tccaaggtga gactgcctag aaatccgtac tctgcggccg atcgaagact      180

gcatttcctc caagaattga tgctcatggt ctcatcttac aatcgcacac acaacagtgt      240

cagtcttctt tgcggtccct tgaacacaac caaccgaaag gtggggaagt ctaatgtcac      300

gcaaacgata ttgcaaccaa tgttgggctc tactggcgtc tggctgcatc aaatagctga      360

tcggttcgta atcttcaaag attggtgtag gacgaacgag tctgctgggc tacaagtttt      420

gccccatatc gctgttcaag ccaacccgcg gaatcccaaa acaccccatc cgacaaaagt      480

tgttgttttc agcagatcta gggagggcat cattgaggtt tccacaaaag gaagaaacat      540

ggatccagag acatcaacag agaggaaagc gggtagtgaa gccgaagcca caacacagcc      600

cgatttggaa gggagttcac aatcaaggtg agtccagcca ttttttttct tttttttttt      660

tttattcagg tgaacccacc taactatttt taactgggat ccagtgagct cgctgggtga      720

aagccaacca tcttttgttt cggggaaccg tgctcgcccc gtaaagttaa tttttttttc      780

ccgcgcagct ttaatctttc ggcagagaag gcgttttcat cgtagcgtgg gaacagaata      840

atcagttcat gtgctataca ggcacatggc agcagtcact attttgcttt ttaaccttaa      900

agtcgttcat caatcattaa ctgaccaatc agattttttg catttgccac ttatctaaaa      960

atacttttgt atctcgcaga tacgttcagt ggtttccagg acaacaccca aaaaaaggta     1020

tcaatgccac taggcagtcg gttttatttt tggtcaccca cgcaaagaag cacccacctc     1080

ttttaggttt taagttgtgg gaacagtaac accgcctaga gcttcaggaa aaaccagtac     1140

ctgtgaccgc aattcaccat gatgcagaat gttaatttaa acgagtgcca aatcaagatt     1200

tcaacagaca aatcaatcga tccatagtta cccattccag ccttttcgtc gtcgagcctg     1260

cttcattcct gcctcaggtg cataactttg catgaaaagt ccagattagg gcagattttg     1320

agtttaaaat aggaaatata aacaaatata ccgcgaaaaa ggtttgttta tagcttttcg     1380

cctggtgccg tacggtataa atacatactc tcctcccccc cctggttctc tttttctttt     1440

gttacttaca ttttaccgtt ccgtcactcg cttcactcaa caacaaaa                  1488


<210>  3
<211>  767
<212>  DNA
<213>  Pichia pastoris

<400>  3
agccaaccat cttttgtttc ggggaaccgt gctcgccccg taaagttaat ttttttttcc       60

cgcgcagctt taatctttcg gcagagaagg cgttttcatc gtagcgtggg aacagaataa      120

tcagttcatg tgctatacag gcacatggca gcagtcacta ttttgctttt taaccttaaa      180

gtcgttcatc aatcattaac tgaccaatca gattttttgc atttgccact tatctaaaaa      240

tacttttgta tctcgcagat acgttcagtg gtttccagga caacacccaa aaaaaggtat      300

caatgccact aggcagtcgg ttttattttt ggtcacccac gcaaagaagc acccacctct      360

tttaggtttt aagttgtggg aacagtaaca ccgcctagag cttcaggaaa aaccagtacc      420

tgtgaccgca attcaccatg atgcagaatg ttaatttaaa cgagtgccaa atcaagattt      480

caacagacaa atcaatcgat ccatagttac ccattccagc cttttcgtcg tcgagcctgc      540

ttcattcctg cctcaggtgc ataactttgc atgaaaagtc cagattaggg cagattttga      600

gtttaaaata ggaaatataa acaaatatac cgcgaaaaag gtttgtttat agcttttcgc      660

ctggtgccgt acggtataaa tacatactct cctccccccc ctggttctct ttttcttttg      720

ttacttacat tttaccgttc cgtcactcgc ttcactcaac aacaaaa                    767


<210>  4
<211>  500
<212>  DNA
<213>  Pichia pastoris

<400>  4
gtggtttcca ggacaacacc caaaaaaagg tatcaatgcc actaggcagt cggttttatt       60

tttggtcacc cacgcaaaga agcacccacc tcttttaggt tttaagttgt gggaacagta      120

acaccgccta gagcttcagg aaaaaccagt acctgtgacc gcaattcacc atgatgcaga      180

atgttaattt aaacgagtgc caaatcaaga tttcaacaga caaatcaatc gatccatagt      240

tacccattcc agccttttcg tcgtcgagcc tgcttcattc ctgcctcagg tgcataactt      300

tgcatgaaaa gtccagatta gggcagattt tgagtttaaa ataggaaata taaacaaata      360

taccgcgaaa aaggtttgtt tatagctttt cgcctggtgc cgtacggtat aaatacatac      420

tctcctcccc cccctggttc tctttttctt ttgttactta cattttaccg ttccgtcact      480

cgcttcactc aacaacaaaa                                                  500


<210>  5
<211>  344
<212>  DNA
<213>  Pichia pastoris

<400>  5
gaccgcaatt caccatgatg cagaatgtta atttaaacga gtgccaaatc aagatttcaa       60

cagacaaatc aatcgatcca tagttaccca ttccagcctt ttcgtcgtcg agcctgcttc      120

attcctgcct caggtgcata actttgcatg aaaagtccag attagggcag attttgagtt      180

taaaatagga aatataaaca aatataccgc gaaaaaggtt tgtttatagc ttttcgcctg      240

gtgccgtacg gtataaatac atactctcct cccccccctg gttctctttt tcttttgtta      300

cttacatttt accgttccgt cactcgcttc actcaacaac aaaa                       344


<210>  6
<211>  234
<212>  DNA
<213>  Pichia pastoris

<400>  6
agcctgcttc attcctgcct caggtgcata actttgcatg aaaagtccag attagggcag       60

attttgagtt taaaatagga aatataaaca aatataccgc gaaaaaggtt tgtttatagc      120

ttttcgcctg gtgccgtacg gtataaatac atactctcct cccccccctg gttctctttt      180

tcttttgtta cttacatttt accgttccgt cactcgcttc actcaacaac aaaa            234


<210>  7
<211>  138
<212>  DNA
<213>  Pichia pastoris

<400>  7
ccgcgaaaaa ggtttgttta tagcttttcg cctggtgccg tacggtataa atacatactc       60

tcctcccccc cctggttctc tttttctttt gttacttaca ttttaccgtt ccgtcactcg      120

cttcactcaa caacaaaa                                                    138


<210>  8
<211>  85
<212>  DNA
<213>  Pichia pastoris

<400>  8
catactctcc tcccccccct ggttctcttt ttcttttgtt acttacattt taccgttccg       60

tcactcgctt cactcaacaa caaaa                                             85


<210>  9
<211>  408
<212>  DNA
<213>  Pichia pastoris

<400>  9
atgcaattct ctatcgtcgc tactttggct cttgctggtt ccgctctggc tgcttactct       60

aacgtaactt acacttacga gactaccatc accgatgttg tcaccgagct caccacttac      120

tgcccagagc caaccacctt cgttcacaag aacaagacca tcactgtgac cgccccaacc      180

actttgacca tcactgactg tccttgcacc atctccaaga ccaccaagat caccactgat      240

gttccaccaa ccacccactc caccccacac accaccacca ctcacgtgcc atctacctct      300

accccagctc caacccactc tgtttctacc atctctcacg gtggtgctgc taaggctggt      360

gttgctggtt tggccggtgt tgctgctgcc gctgcttact tcttgtaa                   408


<210>  10
<211>  135
<212>  PRT
<213>  Pichia pastoris

<400>  10

Met Gln Phe Ser Ile Val Ala Thr Leu Ala Leu Ala Gly Ser Ala Leu 
1               5                   10                  15      


Ala Ala Tyr Ser Asn Val Thr Tyr Thr Tyr Glu Thr Thr Ile Thr Asp 
            20                  25                  30          


Val Val Thr Glu Leu Thr Thr Tyr Cys Pro Glu Pro Thr Thr Phe Val 
        35                  40                  45              


His Lys Asn Lys Thr Ile Thr Val Thr Ala Pro Thr Thr Leu Thr Ile 
    50                  55                  60                  


Thr Asp Cys Pro Cys Thr Ile Ser Lys Thr Thr Lys Ile Thr Thr Asp 
65                  70                  75                  80  


Val Pro Pro Thr Thr His Ser Thr Pro His Thr Thr Thr Thr His Val 
                85                  90                  95      


Pro Ser Thr Ser Thr Pro Ala Pro Thr His Ser Val Ser Thr Ile Ser 
            100                 105                 110         


His Gly Gly Ala Ala Lys Ala Gly Val Ala Gly Leu Ala Gly Val Ala 
        115                 120                 125             


Ala Ala Ala Ala Tyr Phe Leu 
    130                 135 


<210>  11
<211>  402
<212>  DNA
<213>  Pichia pastoris

<400>  11
atgcaattct ctatcgtcgc tactttggct cttgctggtt ccgctctggc tgcttactct       60

aacgtaactt acacttacga gactaccatc accgatgttg tcactgagtt gaccacttac      120

tgcccagagc caaccacctt tgtttacaag aacaagacca tcaccgtgac tgagccaacc      180

actttgacca tcactgactg cccatgcacc atctcaaaga ccaccaagat caccactgat      240

gttccaccaa ccacccacgt caccccatcc accactcacg tgccatctac ctctacccca      300

gctccaaccc actctgtttc taccatctct cacggtggtg ctgctaaggc tggtgttgct      360

ggtttggccg gtgttgctgc tgccgctgct tacttcttgt aa                         402


<210>  12
<211>  133
<212>  PRT
<213>  Pichia pastoris

<400>  12

Met Gln Phe Ser Ile Val Ala Thr Leu Ala Leu Ala Gly Ser Ala Leu 
1               5                   10                  15      


Ala Ala Tyr Ser Asn Val Thr Tyr Thr Tyr Glu Thr Thr Ile Thr Asp 
            20                  25                  30          


Val Val Thr Glu Leu Thr Thr Tyr Cys Pro Glu Pro Thr Thr Phe Val 
        35                  40                  45              


Tyr Lys Asn Lys Thr Ile Thr Val Thr Glu Pro Thr Thr Leu Thr Ile 
    50                  55                  60                  


Thr Asp Cys Pro Cys Thr Ile Ser Lys Thr Thr Lys Ile Thr Thr Asp 
65                  70                  75                  80  


Val Pro Pro Thr Thr His Val Thr Pro Ser Thr Thr His Val Pro Ser 
                85                  90                  95      


Thr Ser Thr Pro Ala Pro Thr His Ser Val Ser Thr Ile Ser His Gly 
            100                 105                 110         


Gly Ala Ala Lys Ala Gly Val Ala Gly Leu Ala Gly Val Ala Ala Ala 
        115                 120                 125             


Ala Ala Tyr Phe Leu 
    130             


<210>  13
<211>  491
<212>  DNA
<213>  Pichia pastoris

<400>  13
cttttttgta gaaatgtctt ggtgtcctcg tccaatcagg tagccatctc tgaaatatct       60

ggctccgttg caactccgaa cgacctgctg gcaacgtaaa attctccggg gtaaaactta      120

aatgtggagt aatggaacca gaaacgtctc ttcccttctc tctccttcca ccgcccgtta      180

ccgtccctag gaaattttac tctgctggag agcttcttct acggccccct tgcagcaatg      240

ctcttcccag cattacgttg cgggtaaaac ggaggtcgtg tacccgacct agcagcccag      300

ggatggaaaa gtcccggccg tcgctggcaa taatagcggg cggacgcatg tcatgagatt      360

attggaaacc accagaatcg aatataaaag gcgaacacct ttcccaattt tggtttctcc      420

tgacccaaag actttaaatt taatttattt gtccctattt caatcaattg aacaactatc      480

acctgcaggc c                                                           491


<210>  14
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  14
gatagggccc cagggcatca ttgaggtttc cac                                    33


<210>  15
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  15
gatacctgca ggttttgttg ttgagtgaag cgagtg                                 36


<210>  16
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  16
gatagggccc cagggcatca ttgaggtttc cac                                    33


<210>  17
<211>  35
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  17
gatagggccc gatagttcta gaagacctgg cgtcg                                  35


<210>  18
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  18
gatagggccc agccaaccat cttttgtttc g                                      31


<210>  19
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  19
gatagggccc gtggtttcca ggacaacacc c                                      31


<210>  20
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  20
gatagggccc gaccgcaatt caccatgatg c                                      31


<210>  21
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  21
gatagggccc agcctgcttc attcctgcc                                         29


<210>  22
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  22
gatagggccc ccgcgaaaaa ggtttgttta tag                                    33


<210>  23
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  23
gatagggccc catactctcc tcccccccct g                                      31


<210>  24
<211>  345
<212>  DNA
<213>  artificial

<220>
<223>  translational fusion partner

<400>  24
ggccattacg gccgggggac ttacatttta ccgttccgtc actcgcttca ctcaacaaca       60

aaaatgcaat tctctatcgt cgctactttg gctcttgctg gttccgctct ggctgcttac      120

tctaacgtaa cttacactta cgagactacc atcaccgatg ttgtcaccga gctcaccact      180

tactgcccag agccaaccac cttcgttcac aagaacaaga ccatcactgt gaccgcccca      240

accactttga ccatcactga ctgtccttgc accatctcca agaccaccaa gatcaccact      300

gatgttccac caaccaccca ctccacccca ctggccgcct cggcc                      345


