                         SEQUENCE LISTING

<110>  Vision Global Holdings Ltd.
       WONG, Bing Lou
 
<120>  PHARMACEUTICAL COMPOSITION COMPRISING ALBUMIN-BINDING ARGININE 
       DEIMINASE FOR CANCER TARGETING TREATMENT

<130>  P6890US01

<140>  PCT/US14/020943
<141>  2014-03-06

<150>  US 61/773,214
<151>  2013-03-06

<150>  US 14/197,236
<151>  2014-03-05

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer,synthesized in lab

<400>  1
catgatgcga attccttagc tgaagctaaa gtcttagcta acagagaact                  50


<210>  2
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer,synthesized in lab

<400>  2
tagtcactta ctccatattt gtcaagttct ctgttagcta agactttagc                  50


<210>  3
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  3
gaacttgaca aatatggagt aagtgactat tacaagaacc taatcaacaa                  50


<210>  4
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  4
tacaccttca acagttttgg cattgttgat taggttcttg taatagtcac                  50


<210>  5
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  5
gccaaaactg ttgaaggtgt aaaagcactg atagatgaaa ttttagctgc                  50


<210>  6
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  6
agctacgata agcttaaggt aatgcagcta aaatttcatc tatcagtg                    48


<210>  7
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  7
catgatgcga attccttagc tgaagctaaa gtcttagcta acagagaact                  50


<210>  8
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  8
agctacgata agcttaaggt aatgcagcta aaatttcatc tatcagtg                    48


<210>  9
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  9
atcgatcgat gtctgtattt gacagtaaat ttaaagg                                37


<210>  10
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  10
agctaaggaa ttcgcatcat gatggtgatg gtggtggcta ccccacttaa c                51


<210>  11
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  11
atcgatcgat gtctgtattt gacagtaaat ttaaagg                                37


<210>  12
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  12
agctacgata agcttaaggt aatgcagcta aaatttcatc tatcagtg                    48


<210>  13
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  13
ggagatatac atatgcatca tcaccatcac catgatgaag ccgtggatg                   49


<210>  14
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  14
ttgttattat tgttgttact acccgaaggt aatgcagcta aaatttcatc                  50


<210>  15
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  15
agaaccgccg ctaccattgt tattattgtt gttactaccc ga                          42


<210>  16
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  16
aataataaca atggtagcgg cggttctgta tttgacagta aatttaaagg                  50


<210>  17
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  17
tagatcaatg gatccttacc acttaacatc tttacgtgat aaag                        44


<210>  18
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  18
ggagatatac atatgcatca tcaccatcac catgatgaag ccgtggatg                   49


<210>  19
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  19
ttgttattat tgttgttact acccgaaggt aatgcagcta aaatttcatc                  50


<210>  20
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  20
tttaccgccg ctaccattgt tattattgtt gttactaccc ga                          42


<210>  21
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  21
aataataaca atggtagcgg cggtaaacat ccgatacatg ttacttcaga                  50


<210>  22
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, synthesized in lab

<400>  22
tagatcaatg gatccctaaa tatctttacg aacaattggc atac                        44


<210>  23
<211>  410
<212>  PRT
<213>  Mycoplasma arginini

<400>  23

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  24
<211>  410
<212>  PRT
<213>  Lactococcus lactis

<400>  24

Met Asn Asn Gly Ile Asn Val Asn Ser Glu Ile Gly Lys Leu Lys Ser 
1               5                   10                  15      


Val Leu Leu His Arg Pro Gly Ala Glu Val Glu Asn Ile Thr Pro Asp 
            20                  25                  30          


Thr Met Lys Gln Leu Leu Phe Asp Asp Ile Pro Tyr Leu Lys Ile Ala 
        35                  40                  45              


Gln Lys Glu His Asp Phe Phe Ala Gln Thr Leu Arg Asp Asn Gly Ala 
    50                  55                  60                  


Glu Thr Val Tyr Ile Glu Asn Leu Ala Thr Glu Val Phe Glu Lys Ser 
65                  70                  75                  80  


Ser Glu Thr Lys Glu Glu Phe Leu Ser His Leu Leu His Glu Ala Gly 
                85                  90                  95      


Tyr Arg Pro Gly Arg Thr Tyr Asp Gly Leu Thr Glu Tyr Leu Thr Ser 
            100                 105                 110         


Met Pro Thr Lys Asp Met Val Glu Lys Val Tyr Ala Gly Val Arg Lys 
        115                 120                 125             


Asn Glu Leu Asp Ile Lys Arg Thr Ala Leu Ser Asp Met Ala Gly Ser 
    130                 135                 140                 


Asp Ala Glu Asn Tyr Phe Tyr Leu Asn Pro Leu Pro Asn Ala Tyr Phe 
145                 150                 155                 160 


Thr Arg Asp Pro Gln Ala Ser Met Gly Val Gly Met Thr Ile Asn Lys 
                165                 170                 175     


Met Thr Phe Pro Ala Arg Gln Pro Glu Ser Leu Ile Thr Glu Tyr Val 
            180                 185                 190         


Met Ala Asn His Pro Arg Phe Lys Asp Thr Pro Ile Trp Arg Asp Arg 
        195                 200                 205             


Asn His Thr Thr Arg Ile Glu Gly Gly Asp Glu Leu Ile Leu Asn Lys 
    210                 215                 220                 


Thr Thr Val Ala Ile Gly Val Ser Glu Arg Thr Ser Ser Lys Thr Ile 
225                 230                 235                 240 


Gln Asn Leu Ala Lys Glu Leu Phe Ala Asn Pro Leu Ser Thr Phe Asp 
                245                 250                 255     


Thr Val Leu Ala Val Glu Ile Pro His Asn His Ala Met Met His Leu 
            260                 265                 270         


Asp Thr Val Phe Thr Met Ile Asn His Asp Gln Phe Thr Val Phe Pro 
        275                 280                 285             


Gly Ile Met Asp Gly Ala Gly Asn Ile Asn Val Phe Ile Leu Arg Pro 
    290                 295                 300                 


Gly Gln Asp Gly Glu Val Glu Ile Glu His Leu Thr Asp Leu Lys Ala 
305                 310                 315                 320 


Ala Leu Lys Lys Val Leu Asn Leu Ser Glu Leu Asp Leu Ile Glu Cys 
                325                 330                 335     


Gly Ala Gly Asp Pro Ile Ala Ala Pro Arg Glu Gln Trp Asn Asp Gly 
            340                 345                 350         


Ser Asn Thr Leu Ala Ile Ala Pro Gly Glu Ile Val Thr Tyr Asp Arg 
        355                 360                 365             


Asn Tyr Val Thr Val Glu Leu Leu Lys Glu His Gly Ile Lys Val His 
    370                 375                 380                 


Glu Ile Leu Ser Ser Glu Leu Gly Arg Gly Arg Gly Gly Ala Arg Cys 
385                 390                 395                 400 


Met Ser Gln Pro Leu Trp Arg Glu Asp Leu 
                405                 410 


<210>  25
<211>  410
<212>  PRT
<213>  Bacillus cereus

<400>  25

Met Lys His Pro Ile His Val Thr Ser Glu Ile Gly Glu Leu Gln Thr 
1               5                   10                  15      


Val Leu Leu Lys Arg Pro Gly Lys Glu Val Glu Asn Leu Thr Pro Asp 
            20                  25                  30          


Tyr Leu Gln Gln Leu Leu Phe Asp Asp Ile Pro Tyr Leu Pro Ile Ile 
        35                  40                  45              


Gln Lys Glu His Asp Tyr Phe Ala Gln Thr Leu Arg Asn Arg Gly Val 
    50                  55                  60                  


Glu Val Leu Tyr Leu Glu Lys Leu Ala Ala Glu Ala Leu Val Asp Lys 
65                  70                  75                  80  


Lys Leu Arg Glu Glu Phe Val Asp Arg Ile Leu Lys Glu Gly Gln Ala 
                85                  90                  95      


Asp Val Asn Val Ala His Gln Thr Leu Lys Glu Tyr Leu Leu Ser Phe 
            100                 105                 110         


Ser Asn Glu Glu Leu Ile Gln Lys Ile Met Gly Gly Val Arg Lys Asn 
        115                 120                 125             


Glu Ile Glu Thr Ser Lys Lys Thr His Leu Tyr Glu Leu Met Glu Asp 
    130                 135                 140                 


His Tyr Pro Phe Tyr Leu Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Ala Ala Ser Val Gly Asp Gly Leu Thr Ile Asn Lys Met Arg 
                165                 170                 175     


Glu Pro Ala Arg Arg Arg Glu Ser Leu Phe Met Glu Tyr Ile Ile Lys 
            180                 185                 190         


Tyr His Pro Arg Phe Ala Lys His Asn Val Pro Ile Trp Leu Asp Arg 
        195                 200                 205             


Asp Tyr Lys Phe Pro Ile Glu Gly Gly Asp Glu Leu Ile Leu Asn Glu 
    210                 215                 220                 


Glu Thr Ile Ala Ile Gly Val Ser Ala Arg Thr Ser Ala Lys Ala Ile 
225                 230                 235                 240 


Glu Arg Leu Ala Lys Asn Leu Phe Ser Arg Gln Asn Lys Ile Lys Lys 
                245                 250                 255     


Val Leu Ala Ile Glu Ile Pro Lys Cys Arg Ala Phe Met His Leu Asp 
            260                 265                 270         


Thr Val Phe Thr Met Val Asp Tyr Asp Lys Phe Thr Ile His Pro Ala 
        275                 280                 285             


Ile Gln Gly Pro Lys Gly Asn Met Asn Ile Tyr Ile Leu Glu Lys Gly 
    290                 295                 300                 


Ala Asp Glu Glu Thr Leu Lys Ile Thr His Arg Thr Ser Leu Met Glu 
305                 310                 315                 320 


Ala Leu Lys Glu Val Leu Asp Leu Ser Glu Leu Val Leu Ile Pro Cys 
                325                 330                 335     


Gly Gly Gly Asp Val Ile Ala Ser Ala Arg Glu Gln Trp Asn Asp Gly 
            340                 345                 350         


Ser Asn Thr Leu Ala Ile Ala Pro Gly Val Val Val Thr Tyr Asp Arg 
        355                 360                 365             


Asn Tyr Val Ser Asn Thr Leu Leu Arg Glu His Gly Ile Glu Val Ile 
    370                 375                 380                 


Glu Val Leu Ser Ser Glu Leu Ser Arg Gly Arg Gly Gly Pro Arg Cys 
385                 390                 395                 400 


Met Ser Met Pro Ile Val Arg Lys Asp Ile 
                405                 410 


<210>  26
<211>  413
<212>  PRT
<213>  Bacillus licheniformis

<400>  26

Met Ile Met Thr Thr Pro Ile His Val Tyr Ser Glu Ile Gly Pro Leu 
1               5                   10                  15      


Lys Thr Val Met Leu Lys Arg Pro Gly Arg Glu Leu Glu Asn Leu Thr 
            20                  25                  30          


Pro Glu Tyr Leu Glu Arg Leu Leu Phe Asp Asp Ile Pro Phe Leu Pro 
        35                  40                  45              


Ala Val Gln Lys Glu His Asp Gln Phe Ala Glu Thr Leu Lys Gln Gln 
    50                  55                  60                  


Gly Ala Glu Val Leu Tyr Leu Glu Lys Leu Thr Ala Glu Ala Leu Asp 
65                  70                  75                  80  


Asp Ala Leu Val Arg Glu Gln Phe Ile Asp Glu Leu Leu Thr Glu Ser 
                85                  90                  95      


Lys Ala Asp Ile Asn Gly Ala Tyr Asp Arg Leu Lys Glu Phe Leu Leu 
            100                 105                 110         


Thr Phe Asp Ala Asp Ser Met Val Glu Gln Val Met Ser Gly Ile Arg 
        115                 120                 125             


Lys Asn Glu Leu Glu Arg Glu Lys Lys Ser His Leu His Glu Leu Met 
    130                 135                 140                 


Glu Asp His Tyr Pro Phe Tyr Leu Asp Pro Met Pro Asn Leu Tyr Phe 
145                 150                 155                 160 


Thr Arg Asp Pro Ala Ala Ala Ile Gly Ser Gly Leu Thr Ile Asn Lys 
                165                 170                 175     


Met Lys Glu Pro Ala Arg Arg Arg Glu Ser Leu Phe Met Arg Tyr Ile 
            180                 185                 190         


Ile Asn His His Pro Arg Phe Lys Gly His Glu Ile Pro Val Trp Leu 
        195                 200                 205             


Asp Arg Asp Phe Lys Phe Asn Ile Glu Gly Gly Asp Glu Leu Val Leu 
    210                 215                 220                 


Asn Glu Glu Thr Val Ala Ile Gly Val Ser Glu Arg Thr Thr Ala Gln 
225                 230                 235                 240 


Ala Ile Glu Arg Leu Val Arg Asn Leu Phe Gln Arg Gln Ser Arg Ile 
                245                 250                 255     


Arg Arg Val Leu Ala Val Glu Ile Pro Lys Ser Arg Ala Phe Met His 
            260                 265                 270         


Leu Asp Thr Val Phe Thr Met Val Asp Arg Asp Gln Phe Thr Ile His 
        275                 280                 285             


Pro Ala Ile Gln Gly Pro Glu Gly Asp Met Arg Ile Phe Val Leu Glu 
    290                 295                 300                 


Arg Gly Lys Thr Ala Asp Glu Ile His Thr Thr Glu Glu His Asn Leu 
305                 310                 315                 320 


Pro Glu Val Leu Lys Arg Thr Leu Gly Leu Ser Asp Val Asn Leu Ile 
                325                 330                 335     


Phe Cys Gly Gly Gly Asp Glu Ile Ala Ser Ala Arg Glu Gln Trp Asn 
            340                 345                 350         


Asp Gly Ser Asn Thr Leu Ala Ile Ala Pro Gly Val Val Val Thr Tyr 
        355                 360                 365             


Asp Arg Asn Tyr Ile Ser Asn Glu Cys Leu Arg Glu Gln Gly Ile Lys 
    370                 375                 380                 


Val Ile Glu Ile Pro Ser Gly Glu Leu Ser Arg Gly Arg Gly Gly Pro 
385                 390                 395                 400 


Arg Cys Met Ser Met Pro Leu Tyr Arg Glu Asp Val Lys 
                405                 410             


<210>  27
<211>  409
<212>  PRT
<213>  Mycoplasma arthritidis

<400>  27

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Lys Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Arg Gly Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Ala Val Lys Lys Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Lys His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ala Glu 
        195                 200                 205             


Gly Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Asp 
    290                 295                 300                 


Ala Pro Gln Pro Val Asp Asn Gly Leu Pro Leu Glu Asp Leu Leu Lys 
305                 310                 315                 320 


Ser Ile Ile Gly Lys Lys Pro Thr Leu Ile Pro Ile Ala Gly Ala Gly 
                325                 330                 335     


Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Val Ala Pro Gly Ile Val Ile Gly Tyr Ala Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe 
    370                 375                 380                 


Arg Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys 
                405                 


<210>  28
<211>  409
<212>  PRT
<213>  Mycoplasma hominis

<400>  28

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Ile 
    50                  55                  60                  


Met Lys Asp Arg Gly Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Ala Ala Lys Glu Glu Phe Ile Glu 
                85                  90                  95      


Thr Phe Leu Glu Glu Thr Val Pro Val Leu Thr Glu Ala Asn Lys Lys 
            100                 105                 110         


Ala Val Arg Ala Phe Leu Leu Ser Lys Pro Thr His Glu Met Val Glu 
        115                 120                 125             


Phe Met Met Ser Gly Ile Thr Lys Tyr Glu Leu Gly Val Glu Ser Glu 
    130                 135                 140                 


Asn Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp 
145                 150                 155                 160 


Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Phe Met Arg Tyr 
                165                 170                 175     


Ile Val Arg Arg Arg Glu Thr Leu Phe Ala Arg Phe Val Phe Arg Asn 
            180                 185                 190         


His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro Ala Met Lys 
        195                 200                 205             


Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Glu Thr Leu 
    210                 215                 220                 


Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu Leu 
225                 230                 235                 240 


Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys Arg Ile Val 
                245                 250                 255     


Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr Trp 
            260                 265                 270         


Leu Thr Met Leu Asp Lys Asn Lys Phe Leu Tyr Ser Pro Ile Ala Asn 
        275                 280                 285             


Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala Glu 
    290                 295                 300                 


Pro Gln Pro Gln Leu Asn Gly Leu Pro Leu Asp Lys Leu Leu Ala Ser 
305                 310                 315                 320 


Ile Ile Asn Lys Glu Pro Val Leu Ile Pro Ile Gly Gly Ala Gly Ala 
                325                 330                 335     


Thr Glu Met Glu Ile Ala Arg Glu Thr Asn Phe Asp Gly Thr Asn Tyr 
            340                 345                 350         


Leu Ala Ile Lys Pro Gly Leu Val Ile Gly Tyr Asp Arg Asn Glu Lys 
        355                 360                 365             


Thr Asn Ala Ala Leu Lys Ala Ala Gly Ile Thr Val Leu Pro Phe His 
    370                 375                 380                 


Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser Met 
385                 390                 395                 400 


Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 


<210>  29
<211>  411
<212>  PRT
<213>  Streptococcus pyogenes

<400>  29

Met Thr Ala Gln Thr Pro Ile His Val Tyr Ser Glu Ile Gly Lys Leu 
1               5                   10                  15      


Lys Lys Val Leu Leu His Arg Pro Gly Lys Glu Ile Glu Asn Leu Met 
            20                  25                  30          


Pro Asp Tyr Leu Glu Arg Leu Leu Phe Asp Asp Ile Pro Phe Leu Glu 
        35                  40                  45              


Asp Ala Gln Lys Glu His Asp Ala Phe Ala Gln Ala Leu Arg Asp Glu 
    50                  55                  60                  


Gly Ile Glu Val Leu Tyr Leu Glu Thr Leu Ala Ala Glu Ser Leu Val 
65                  70                  75                  80  


Thr Pro Glu Ile Arg Glu Ala Phe Ile Asp Glu Tyr Leu Ser Glu Ala 
                85                  90                  95      


Asn Ile Arg Gly Arg Ala Thr Lys Lys Ala Ile Arg Glu Leu Leu Met 
            100                 105                 110         


Ala Ile Glu Asp Asn Gln Glu Leu Ile Glu Lys Thr Met Ala Gly Val 
        115                 120                 125             


Gln Lys Ser Glu Leu Pro Glu Ile Pro Ala Ser Glu Lys Gly Leu Thr 
    130                 135                 140                 


Asp Leu Val Glu Ser Ser Tyr Pro Phe Ala Ile Asp Pro Met Pro Asn 
145                 150                 155                 160 


Leu Tyr Phe Thr Arg Asp Pro Phe Ala Thr Ile Gly Thr Gly Val Ser 
                165                 170                 175     


Leu Asn His Met Phe Ser Glu Thr Arg Asn Arg Glu Thr Leu Tyr Gly 
            180                 185                 190         


Lys Tyr Ile Phe Thr His His Pro Ile Tyr Gly Gly Gly Lys Val Pro 
        195                 200                 205             


Met Val Tyr Asp Arg Asn Glu Thr Thr Arg Ile Glu Gly Gly Asp Glu 
    210                 215                 220                 


Leu Val Leu Ser Lys Asp Val Leu Ala Val Gly Ile Ser Gln Arg Thr 
225                 230                 235                 240 


Asp Ala Ala Ser Ile Glu Lys Leu Leu Val Asn Ile Phe Lys Gln Asn 
                245                 250                 255     


Leu Gly Phe Lys Lys Val Leu Ala Phe Glu Phe Ala Asn Asn Arg Lys 
            260                 265                 270         


Phe Met His Leu Asp Thr Val Phe Thr Met Val Asp Tyr Asp Lys Phe 
        275                 280                 285             


Thr Ile His Pro Glu Ile Glu Gly Asp Leu Arg Val Tyr Ser Val Thr 
    290                 295                 300                 


Tyr Asp Asn Glu Glu Leu His Ile Val Glu Glu Lys Gly Asp Leu Ala 
305                 310                 315                 320 


Asp Leu Leu Ala Ala Asn Leu Gly Val Glu Lys Val Asp Leu Ile Arg 
                325                 330                 335     


Cys Gly Gly Asp Asn Leu Val Ala Ala Gly Arg Glu Gln Trp Asn Asp 
            340                 345                 350         


Gly Ser Asn Thr Leu Thr Ile Ala Pro Gly Val Val Val Val Tyr Asn 
        355                 360                 365             


Arg Asn Thr Ile Thr Asn Ala Ile Leu Glu Ser Lys Gly Leu Lys Leu 
    370                 375                 380                 


Ile Lys Ile His Gly Ser Glu Leu Val Arg Gly Arg Gly Gly Pro Arg 
385                 390                 395                 400 


Cys Met Ser Met Pro Phe Glu Arg Glu Asp Ile 
                405                 410     


<210>  30
<211>  409
<212>  PRT
<213>  Streptococcus pneumonia

<400>  30

Met Ser Ser His Pro Ile Gln Val Phe Ser Glu Ile Gly Lys Leu Lys 
1               5                   10                  15      


Lys Val Met Leu His Arg Pro Gly Lys Glu Leu Glu Asn Leu Leu Pro 
            20                  25                  30          


Asp Tyr Leu Glu Arg Leu Leu Phe Asp Asp Ile Pro Phe Leu Glu Asp 
        35                  40                  45              


Ala Gln Lys Glu His Asp Ala Phe Ala Gln Ala Leu Arg Asp Glu Gly 
    50                  55                  60                  


Ile Glu Val Leu Tyr Leu Glu Gln Leu Ala Ala Glu Ser Leu Thr Ser 
65                  70                  75                  80  


Pro Glu Ile Arg Asp Gln Phe Ile Glu Glu Tyr Leu Asp Glu Ala Asn 
                85                  90                  95      


Ile Arg Asp Arg Gln Thr Lys Val Ala Ile Arg Glu Leu Leu His Gly 
            100                 105                 110         


Ile Lys Asp Asn Gln Glu Leu Val Glu Lys Thr Met Ala Gly Ile Gln 
        115                 120                 125             


Lys Val Glu Leu Pro Glu Ile Pro Asp Glu Ala Lys Asp Leu Thr Asp 
    130                 135                 140                 


Leu Val Glu Ser Asp Tyr Pro Phe Ala Ile Asp Pro Met Pro Asn Leu 
145                 150                 155                 160 


Tyr Phe Thr Arg Asp Pro Phe Ala Thr Ile Gly Asn Ala Val Ser Leu 
                165                 170                 175     


Asn His Met Phe Ala Asp Thr Arg Asn Arg Glu Thr Leu Tyr Gly Lys 
            180                 185                 190         


Tyr Ile Phe Lys Tyr His Pro Ile Tyr Gly Gly Lys Val Asp Leu Val 
        195                 200                 205             


Tyr Asn Arg Glu Glu Asp Thr Arg Ile Glu Gly Gly Asp Glu Leu Val 
    210                 215                 220                 


Leu Ser Lys Asp Val Leu Ala Val Gly Ile Ser Gln Arg Thr Asp Ala 
225                 230                 235                 240 


Ala Ser Ile Glu Lys Leu Leu Val Asn Ile Phe Lys Lys Asn Val Gly 
                245                 250                 255     


Phe Lys Lys Val Leu Ala Phe Glu Phe Ala Asn Asn Arg Lys Phe Met 
            260                 265                 270         


His Leu Asp Thr Val Phe Thr Met Val Asp Tyr Asp Lys Phe Thr Ile 
        275                 280                 285             


His Pro Glu Ile Glu Gly Asp Leu His Val Tyr Ser Val Thr Tyr Glu 
    290                 295                 300                 


Asn Glu Lys Leu Lys Ile Val Glu Glu Lys Gly Asp Leu Ala Glu Leu 
305                 310                 315                 320 


Leu Ala Gln Asn Leu Gly Val Glu Lys Val His Leu Ile Arg Cys Gly 
                325                 330                 335     


Gly Gly Asn Ile Val Ala Ala Ala Arg Glu Gln Trp Asn Asp Gly Ser 
            340                 345                 350         


Asn Thr Leu Thr Ile Ala Pro Gly Val Val Val Val Tyr Asp Arg Asn 
        355                 360                 365             


Thr Val Thr Asn Lys Ile Leu Glu Glu Tyr Gly Leu Arg Leu Ile Lys 
    370                 375                 380                 


Ile Arg Gly Ser Glu Leu Val Arg Gly Arg Gly Gly Pro Arg Cys Met 
385                 390                 395                 400 


Ser Met Pro Phe Glu Arg Glu Glu Val 
                405                 


<210>  31
<211>  402
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  31

Met Gly Val Glu Leu Gly Ser Asn Ser Glu Val Gly Ala Leu Arg Val 
1               5                   10                  15      


Val Ile Leu His Arg Pro Gly Ala Glu Leu Arg Arg Leu Thr Pro Arg 
            20                  25                  30          


Asn Thr Asp Gln Leu Leu Phe Asp Gly Leu Pro Trp Val Ser Arg Ala 
        35                  40                  45              


Gln Asp Glu His Asp Glu Phe Ala Glu Leu Leu Ala Ser Arg Gly Ala 
    50                  55                  60                  


Glu Val Leu Leu Leu Ser Asp Leu Leu Thr Glu Ala Leu His His Ser 
65                  70                  75                  80  


Gly Ala Ala Arg Met Gln Gly Ile Ala Ala Ala Val Asp Ala Pro Arg 
                85                  90                  95      


Leu Gly Leu Pro Leu Ala Gln Glu Leu Ser Ala Tyr Leu Arg Ser Leu 
            100                 105                 110         


Asp Pro Gly Arg Leu Ala His Val Leu Thr Ala Gly Met Thr Phe Asn 
        115                 120                 125             


Glu Leu Pro Ser Asp Thr Arg Thr Asp Val Ser Leu Val Leu Arg Met 
    130                 135                 140                 


His His Gly Gly Asp Phe Val Ile Glu Pro Leu Pro Asn Leu Val Phe 
145                 150                 155                 160 


Thr Arg Asp Ser Ser Ile Trp Ile Gly Pro Arg Val Val Ile Pro Ser 
                165                 170                 175     


Leu Ala Leu Arg Ala Arg Val Arg Glu Ala Ser Leu Thr Asp Leu Ile 
            180                 185                 190         


Tyr Ala His His Pro Arg Phe Thr Gly Val Arg Arg Ala Tyr Glu Ser 
        195                 200                 205             


Arg Thr Ala Pro Val Glu Gly Gly Asp Val Leu Leu Leu Ala Pro Gly 
    210                 215                 220                 


Val Val Ala Val Gly Val Gly Glu Arg Thr Thr Pro Ala Gly Ala Glu 
225                 230                 235                 240 


Ala Leu Ala Arg Ser Leu Phe Asp Asp Asp Leu Ala His Thr Val Leu 
                245                 250                 255     


Ala Val Pro Ile Ala Gln Gln Arg Ala Gln Met His Leu Asp Thr Val 
            260                 265                 270         


Cys Thr Met Val Asp Thr Asp Thr Met Val Met Tyr Ala Asn Val Val 
        275                 280                 285             


Asp Thr Leu Glu Ala Phe Thr Ile Gln Arg Thr Pro Asp Gly Val Thr 
    290                 295                 300                 


Ile Gly Asp Ala Ala Pro Phe Ala Glu Ala Ala Ala Lys Ala Met Gly 
305                 310                 315                 320 


Ile Asp Lys Leu Arg Val Ile His Thr Gly Met Asp Pro Val Val Ala 
                325                 330                 335     


Glu Arg Glu Gln Trp Asp Asp Gly Asn Asn Thr Leu Ala Leu Ala Pro 
            340                 345                 350         


Gly Val Val Val Ala Tyr Glu Arg Asn Val Gln Thr Asn Ala Arg Leu 
        355                 360                 365             


Gln Asp Ala Gly Ile Glu Val Leu Thr Ile Ala Gly Ser Glu Leu Gly 
    370                 375                 380                 


Thr Gly Arg Gly Gly Pro Arg Cys Met Ser Cys Pro Ala Ala Arg Asp 
385                 390                 395                 400 


Pro Leu 
        


<210>  32
<211>  417
<212>  PRT
<213>  Pseudomonas plecoglossicida

<400>  32

Met Ser Thr Glu Lys Gln Lys Tyr Gly Val His Ser Glu Ala Gly Lys 
1               5                   10                  15      


Leu Arg Lys Val Met Val Cys Ser Pro Gly Leu Ala His Lys Arg Leu 
            20                  25                  30          


Thr Pro Ser Asn Cys Asp Glu Leu Leu Phe Asp Asp Val Ile Trp Val 
        35                  40                  45              


Asp Gln Ala Lys Arg Asp His Phe Asp Phe Val Thr Lys Met Arg Glu 
    50                  55                  60                  


Arg Gly Val Asp Val Leu Glu Met His Asn Leu Leu Thr Asp Ile Val 
65                  70                  75                  80  


Gln Asp Lys Asn Ala Leu Lys Trp Ile Leu Asp Arg Lys Leu Thr Asp 
                85                  90                  95      


Asp Thr Val Gly Val Gly Leu Lys Asn Glu Val Arg Ser Trp Leu Glu 
            100                 105                 110         


Gly Gln Asp Pro Arg His Leu Ala Glu Phe Leu Ile Gly Gly Val Ala 
        115                 120                 125             


Gly Gln Asp Leu Pro Gln Ser Glu Gly Ala Asp Val Val Lys Met Tyr 
    130                 135                 140                 


Asn Asp Tyr Leu Gly His Ser Ser Phe Ile Leu Pro Pro Leu Pro Asn 
145                 150                 155                 160 


Thr Gln Phe Thr Arg Asp Thr Thr Cys Trp Ile Tyr Gly Gly Val Thr 
                165                 170                 175     


Leu Asn Pro Met Tyr Trp Pro Ala Arg Arg Gln Glu Thr Leu Leu Thr 
            180                 185                 190         


Thr Ala Ile Tyr Lys Phe His Lys Glu Phe Thr Asn Ala Glu Phe Glu 
        195                 200                 205             


Val Trp Tyr Gly Asp Pro Asp Lys Glu His Gly Ser Ser Thr Leu Glu 
    210                 215                 220                 


Gly Gly Asp Val Met Pro Ile Gly Lys Gly Ile Val Leu Ile Gly Met 
225                 230                 235                 240 


Gly Glu Arg Thr Ser Arg Gln Ala Ile Gly Gln Leu Ala Arg Asn Leu 
                245                 250                 255     


Phe Glu Lys Gly Ala Ala Thr Glu Val Ile Val Ala Gly Leu Pro Lys 
            260                 265                 270         


Ser Arg Ala Ala Met His Leu Asp Thr Val Phe Ser Phe Cys Asp Arg 
        275                 280                 285             


Asp Leu Val Thr Val Phe Pro Glu Val Val Asn Glu Ile Val Pro Phe 
    290                 295                 300                 


Ile Ile Arg Pro Asp Glu Lys Lys Pro Tyr Gly Met Asp Val Arg Arg 
305                 310                 315                 320 


Ile Asn Lys Ser Phe Ile Glu Val Val Gly Glu Gln Leu Gly Val Lys 
                325                 330                 335     


Leu Arg Val Val Glu Thr Gly Gly Asn Ser Phe Ala Ala Glu Arg Glu 
            340                 345                 350         


Gln Trp Asp Asp Gly Asn Asn Val Val Ala Ile Glu Pro Gly Val Val 
        355                 360                 365             


Ile Gly Tyr Asp Arg Asn Thr Tyr Thr Asn Thr Leu Leu Arg Lys Ala 
    370                 375                 380                 


Gly Ile Glu Val Ile Thr Ile Ser Ala Gly Glu Leu Gly Arg Gly Arg 
385                 390                 395                 400 


Gly Gly Gly His Cys Met Thr Cys Pro Ile Val Arg Asp Pro Ile Asp 
                405                 410                 415     


Tyr 
    


<210>  33
<211>  420
<212>  PRT
<213>  Pseudomonas putida

<400>  33

Met Ser Ala Glu Lys Gln Lys Tyr Gly Val His Ser Glu Ala Gly Lys 
1               5                   10                  15      


Leu Arg Lys Val Met Val Cys Ser Pro Gly Leu Ala His Lys Arg Leu 
            20                  25                  30          


Thr Pro Ser Asn Cys Asp Glu Leu Leu Phe Asp Asp Val Ile Trp Val 
        35                  40                  45              


Asp Gln Ala Lys Arg Asp His Phe Asp Phe Val Thr Lys Met Arg Glu 
    50                  55                  60                  


Arg Gly Val Asp Val Leu Glu Met His Asn Leu Leu Thr Asp Ile Val 
65                  70                  75                  80  


Gln Gln Pro Glu Ala Leu Lys Trp Ile Leu Asp Arg Lys Ile Thr Ser 
                85                  90                  95      


Asp Thr Val Gly Val Gly Leu Thr Asn Glu Val Arg Ser Trp Leu Glu 
            100                 105                 110         


Gly Leu Glu Pro Arg His Leu Ala Glu Phe Leu Ile Gly Gly Val Ala 
        115                 120                 125             


Gly Gln Asp Leu Pro Val Ser Glu Gly Ala Glu Val Ile Lys Met Tyr 
    130                 135                 140                 


Asn Lys Tyr Leu Gly His Ser Ser Phe Ile Leu Pro Pro Leu Pro Asn 
145                 150                 155                 160 


Thr Gln Phe Thr Arg Asp Thr Thr Cys Trp Ile Tyr Gly Gly Val Thr 
                165                 170                 175     


Leu Asn Pro Met Tyr Trp Pro Ala Arg Arg Gln Glu Thr Leu Leu Thr 
            180                 185                 190         


Thr Ala Ile Tyr Lys Phe His Lys Glu Phe Thr Gly Ala Asp Phe Gln 
        195                 200                 205             


Val Trp Tyr Gly Asp Pro Asp Lys Asp His Gly Asn Ala Thr Leu Glu 
    210                 215                 220                 


Gly Gly Asp Val Met Pro Val Gly Lys Gly Ile Val Leu Ile Gly Met 
225                 230                 235                 240 


Gly Glu Arg Thr Ser Arg His Ala Ile Gly Gln Leu Ala Gln Asn Leu 
                245                 250                 255     


Phe Glu Lys Gly Ala Ala Glu Lys Ile Ile Val Ala Gly Leu Pro Lys 
            260                 265                 270         


Ser Arg Ala Ala Met His Leu Asp Thr Val Phe Ser Phe Cys Asp Arg 
        275                 280                 285             


Asp Leu Val Thr Val Phe Pro Glu Val Val Lys Glu Ile Lys Pro Phe 
    290                 295                 300                 


Ile Ile Thr Pro Asp Ser Ser Lys Pro Tyr Gly Met Asn Ile Ala Pro 
305                 310                 315                 320 


Gln Asp Ala Ser Phe Leu Glu Val Val Ser Glu Gln Leu Leu Gly Lys 
                325                 330                 335     


Lys Asp Lys Leu Arg Val Val Glu Thr Gly Gly Asn Ser Phe Ala Ala 
            340                 345                 350         


Glu Arg Glu Gln Trp Asp Asp Gly Asn Asn Val Val Ala Leu Glu Pro 
        355                 360                 365             


Gly Val Val Ile Gly Tyr Asp Arg Asn Thr Tyr Thr Asn Thr Leu Leu 
    370                 375                 380                 


Arg Lys Ala Gly Ile Glu Val Ile Thr Ile Ser Ala Gly Glu Leu Gly 
385                 390                 395                 400 


Arg Gly Arg Gly Gly Gly His Cys Met Thr Cys Pro Ile Val Arg Asp 
                405                 410                 415     


Pro Ile Asp Tyr 
            420 


<210>  34
<211>  418
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  34

Met Ser Thr Glu Lys Thr Lys Leu Gly Val His Ser Glu Ala Gly Lys 
1               5                   10                  15      


Leu Arg Lys Val Met Val Cys Ser Pro Gly Leu Ala His Gln Arg Leu 
            20                  25                  30          


Thr Pro Ser Asn Cys Asp Glu Leu Leu Phe Asp Asp Val Ile Trp Val 
        35                  40                  45              


Asn Gln Ala Lys Arg Asp His Phe Asp Phe Val Thr Lys Met Arg Glu 
    50                  55                  60                  


Arg Gly Ile Asp Val Leu Glu Met His Asn Leu Leu Thr Glu Thr Ile 
65                  70                  75                  80  


Gln Asn Pro Glu Ala Leu Lys Trp Ile Leu Asp Arg Lys Ile Thr Ala 
                85                  90                  95      


Asp Ser Val Gly Leu Gly Leu Thr Ser Glu Leu Arg Ser Trp Leu Glu 
            100                 105                 110         


Ser Leu Glu Pro Arg Lys Leu Ala Glu Tyr Leu Ile Gly Gly Val Ala 
        115                 120                 125             


Ala Asp Asp Leu Pro Ala Ser Glu Gly Ala Asn Ile Leu Lys Met Tyr 
    130                 135                 140                 


Arg Glu Tyr Leu Gly His Ser Ser Phe Leu Leu Pro Pro Leu Pro Asn 
145                 150                 155                 160 


Thr Gln Phe Thr Arg Asp Thr Thr Cys Trp Ile Tyr Gly Gly Val Thr 
                165                 170                 175     


Leu Asn Pro Met Tyr Trp Pro Ala Arg Arg Gln Glu Thr Leu Leu Thr 
            180                 185                 190         


Thr Ala Ile Tyr Lys Phe His Pro Glu Phe Ala Asn Ala Glu Phe Glu 
        195                 200                 205             


Ile Trp Tyr Gly Asp Pro Asp Lys Asp His Gly Ser Ser Thr Leu Glu 
    210                 215                 220                 


Gly Gly Asp Val Met Pro Ile Gly Asn Gly Val Val Leu Ile Gly Met 
225                 230                 235                 240 


Gly Glu Arg Ser Ser Arg Gln Ala Ile Gly Gln Val Ala Gln Ser Leu 
                245                 250                 255     


Phe Ala Lys Gly Ala Ala Glu Arg Val Ile Val Ala Gly Leu Pro Lys 
            260                 265                 270         


Ser Arg Ala Ala Met His Leu Asp Thr Val Phe Ser Phe Cys Asp Arg 
        275                 280                 285             


Asp Leu Val Thr Val Phe Pro Glu Val Val Lys Glu Ile Val Pro Phe 
    290                 295                 300                 


Ser Leu Arg Pro Asp Pro Ser Ser Pro Tyr Gly Met Asn Ile Arg Arg 
305                 310                 315                 320 


Glu Glu Lys Thr Phe Leu Glu Val Val Ala Glu Ser Leu Gly Leu Lys 
                325                 330                 335     


Lys Leu Arg Val Val Glu Thr Gly Gly Asn Ser Phe Ala Ala Glu Arg 
            340                 345                 350         


Glu Gln Trp Asp Asp Gly Asn Asn Val Val Cys Leu Glu Pro Gly Val 
        355                 360                 365             


Val Val Gly Tyr Asp Arg Asn Thr Tyr Thr Asn Thr Leu Leu Arg Lys 
    370                 375                 380                 


Ala Gly Val Glu Val Ile Thr Ile Ser Ala Ser Glu Leu Gly Arg Gly 
385                 390                 395                 400 


Arg Gly Gly Gly His Cys Met Thr Cys Pro Ile Val Arg Asp Pro Ile 
                405                 410                 415     


Asp Tyr 
        


<210>  35
<211>  409
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  35

Met Ser Ser His Pro Ile Gln Val Phe Ser Glu Ile Gly Lys Leu Lys 
1               5                   10                  15      


Lys Val Met Leu His Arg Pro Gly Lys Glu Leu Glu Asn Leu Leu Pro 
            20                  25                  30          


Asp Tyr Leu Glu Arg Leu Leu Phe Asp Asp Ile Pro Phe Leu Glu Asp 
        35                  40                  45              


Ala Gln Lys Glu His Asp Ala Phe Ala Gln Ala Leu Arg Asp Glu Gly 
    50                  55                  60                  


Ile Glu Val Leu Tyr Leu Glu Gln Leu Ala Ala Glu Ser Leu Thr Ser 
65                  70                  75                  80  


Pro Glu Ile Arg Asp Gln Phe Ile Glu Glu Tyr Leu Asp Glu Ala Asn 
                85                  90                  95      


Ile Arg Asp Arg Gln Thr Lys Val Ala Ile Arg Glu Leu Leu His Gly 
            100                 105                 110         


Ile Lys Asp Asn Gln Glu Leu Val Glu Lys Thr Met Ala Gly Ile Gln 
        115                 120                 125             


Lys Val Glu Leu Pro Glu Ile Pro Asp Glu Ala Lys Asp Leu Thr Asp 
    130                 135                 140                 


Leu Val Glu Ser Asp Tyr Pro Phe Ala Ile Asp Pro Met Pro Asn Leu 
145                 150                 155                 160 


Tyr Phe Thr Arg Asp Pro Phe Ala Thr Ile Gly Asn Ala Val Ser Leu 
                165                 170                 175     


Asn His Met Phe Ala Asp Thr Arg Asn Arg Glu Thr Leu Tyr Gly Lys 
            180                 185                 190         


Tyr Ile Phe Lys Tyr His Pro Ile Tyr Gly Gly Lys Val Asp Leu Val 
        195                 200                 205             


Tyr Asn Arg Glu Glu Asp Thr Arg Ile Glu Gly Gly Asp Glu Leu Val 
    210                 215                 220                 


Leu Ser Lys Asp Val Leu Ala Val Gly Ile Ser Gln Arg Thr Asp Ala 
225                 230                 235                 240 


Ala Ser Ile Glu Lys Leu Leu Val Asn Ile Phe Lys Lys Asn Val Gly 
                245                 250                 255     


Phe Lys Lys Val Leu Ala Phe Glu Phe Ala Asn Asn Arg Lys Phe Met 
            260                 265                 270         


His Leu Asp Thr Val Phe Thr Met Val Asp Tyr Asp Lys Phe Thr Ile 
        275                 280                 285             


His Pro Glu Ile Glu Gly Asp Leu His Val Tyr Ser Val Thr Tyr Glu 
    290                 295                 300                 


Asn Glu Lys Leu Lys Ile Val Glu Glu Lys Gly Asp Leu Ala Glu Leu 
305                 310                 315                 320 


Leu Ala Gln Asn Leu Gly Val Glu Lys Val His Leu Ile Arg Cys Gly 
                325                 330                 335     


Gly Gly Asn Ile Val Ala Ala Ala Arg Glu Gln Trp Asn Asp Gly Ser 
            340                 345                 350         


Asn Thr Leu Thr Ile Ala Pro Gly Val Val Val Val Tyr Asp Arg Asn 
        355                 360                 365             


Thr Val Thr Asn Lys Ile Leu Glu Glu Tyr Gly Leu Arg Leu Ile Lys 
    370                 375                 380                 


Ile Arg Gly Ser Glu Leu Val Arg Gly Arg Gly Gly Pro Arg Cys Met 
385                 390                 395                 400 


Ser Met Pro Phe Glu Arg Glu Glu Val 
                405                 


<210>  36
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD1, synthesized in lab

<400>  36

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp Gly Ser His His His His 
                405                 410                 415     


His His Ala Asn Ser Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu 
            420                 425                 430         


Leu Asp Lys Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asn Lys 
        435                 440                 445             


Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Leu His Ile Leu Ala 
    450                 455                 460                 


Ala Leu Pro 
465         


<210>  37
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD, synthesized in lab

<400>  37

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp Ala Gln His Asp Glu Ala 
                405                 410                 415     


Val Asp Ala Asn Ser Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu 
            420                 425                 430         


Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn 
        435                 440                 445             


Ala Lys Thr Val Glu Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala 
    450                 455                 460                 


Ala Leu Pro 
465         


<210>  38
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD, synthesized in lab

<400>  38

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp His His His His His His 
                405                 410                 415     


Ala Gln His Asp Glu Ala Val Asp Ala Asn Ser Leu Ala Glu Ala Lys 
            420                 425                 430         


Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 
        435                 440                 445             


Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala Leu 
    450                 455                 460                 


Ile Asp Glu Ile Leu Ala Ala Leu Pro 
465                 470             


<210>  39
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD, synthesized in lab

<400>  39

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp Ala Gln His Asp Glu Ala 
                405                 410                 415     


Val Asp Ala Asn Ser Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu 
            420                 425                 430         


Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn 
        435                 440                 445             


Ala Lys Thr Val Glu Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala 
    450                 455                 460                 


Ala Leu Pro His His His His His His 
465                 470             


<210>  40
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD, synthesized in lab

<400>  40

Met His His His His His His Asp Glu Ala Val Asp Ala Asn Ser Leu 
1               5                   10                  15      


Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val 
            20                  25                  30          


Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly 
        35                  40                  45              


Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro Ser Gly Ser 
    50                  55                  60                  


Asn Asn Asn Asn Asn Asn Gly Ser Gly Gly Ser Val Phe Asp Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Ile His Val Tyr Ser Glu Ile Gly Glu Leu Glu Ser Val 
                85                  90                  95      


Leu Val His Glu Pro Gly Arg Glu Ile Asp Tyr Ile Thr Pro Ala Arg 
            100                 105                 110         


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Ser His Asp Ala Arg 
        115                 120                 125             


Lys Glu His Lys Gln Phe Val Ala Glu Leu Lys Ala Asn Asp Ile Asn 
    130                 135                 140                 


Val Val Glu Leu Ile Asp Leu Val Ala Glu Thr Tyr Asp Leu Ala Ser 
145                 150                 155                 160 


Gln Glu Ala Lys Asp Lys Leu Ile Glu Glu Phe Leu Glu Asp Ser Glu 
                165                 170                 175     


Pro Val Leu Ser Glu Glu His Lys Val Val Val Arg Asn Phe Leu Lys 
            180                 185                 190         


Ala Lys Lys Thr Ser Arg Glu Leu Val Glu Ile Met Met Ala Gly Ile 
        195                 200                 205             


Thr Lys Tyr Asp Leu Gly Ile Glu Ala Asp His Glu Leu Ile Val Asp 
    210                 215                 220                 


Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser Val Gly 
225                 230                 235                 240 


Asn Gly Val Thr Ile His Tyr Met Arg Tyr Lys Val Arg Gln Arg Glu 
                245                 250                 255     


Thr Leu Phe Ser Arg Phe Val Phe Ser Asn His Pro Lys Leu Ile Asn 
            260                 265                 270         


Thr Pro Trp Tyr Tyr Asp Pro Ser Leu Lys Leu Ser Ile Glu Gly Gly 
        275                 280                 285             


Asp Val Phe Ile Tyr Asn Asn Asp Thr Leu Val Val Gly Val Ser Glu 
    290                 295                 300                 


Arg Thr Asp Leu Gln Thr Val Thr Leu Leu Ala Lys Asn Ile Val Ala 
305                 310                 315                 320 


Asn Lys Glu Cys Glu Phe Lys Arg Ile Val Ala Ile Asn Val Pro Lys 
                325                 330                 335     


Trp Thr Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Leu Asp Lys 
            340                 345                 350         


Asp Lys Phe Leu Tyr Ser Pro Ile Ala Asn Asp Val Phe Lys Phe Trp 
        355                 360                 365             


Asp Tyr Asp Leu Val Asn Gly Gly Ala Glu Pro Gln Pro Val Glu Asn 
    370                 375                 380                 


Gly Leu Pro Leu Glu Gly Leu Leu Gln Ser Ile Ile Asn Lys Lys Pro 
385                 390                 395                 400 


Val Leu Ile Pro Ile Ala Gly Glu Gly Ala Ser Gln Met Glu Ile Glu 
                405                 410                 415     


Arg Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Ala Ile Arg Pro Gly 
            420                 425                 430         


Val Val Ile Gly Tyr Ser Arg Asn Glu Lys Thr Asn Ala Ala Leu Glu 
        435                 440                 445             


Ala Ala Gly Ile Lys Val Leu Pro Phe His Gly Asn Gln Leu Ser Leu 
    450                 455                 460                 


Gly Met Gly Asn Ala Arg Cys Met Ser Met Pro Leu Ser Arg Lys Asp 
465                 470                 475                 480 


Val Lys Trp 
            


<210>  41
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-ABD-PolyN-bcADI, synthesized in lab

<400>  41

Met Gly His His His His His His Asp Glu Ala Val Asp Ala Asn Ser 
1               5                   10                  15      


Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
            20                  25                  30          


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu 
        35                  40                  45              


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro Ser Gly 
    50                  55                  60                  


Ser Asn Asn Asn Asn Asn Asn Gly Ser Gly Gly Lys His Pro Ile His 
65                  70                  75                  80  


Val Thr Ser Glu Ile Gly Glu Leu Gln Thr Val Leu Leu Lys Arg Pro 
                85                  90                  95      


Gly Lys Glu Val Glu Asn Leu Thr Pro Asp Tyr Leu Gln Gln Leu Leu 
            100                 105                 110         


Phe Asp Asp Ile Pro Tyr Leu Pro Ile Ile Gln Lys Glu His Asp Tyr 
        115                 120                 125             


Phe Ala Gln Thr Leu Arg Asn Arg Gly Val Glu Val Leu Tyr Leu Glu 
    130                 135                 140                 


Lys Leu Ala Ala Glu Ala Leu Val Asp Lys Lys Leu Arg Glu Glu Phe 
145                 150                 155                 160 


Val Asp Arg Ile Leu Lys Glu Gly Gln Ala Asp Val Asn Val Ala His 
                165                 170                 175     


Gln Thr Leu Lys Glu Tyr Leu Leu Ser Phe Ser Asn Glu Glu Leu Ile 
            180                 185                 190         


Gln Lys Ile Met Glu Thr Gly Gly Val Arg Lys Asn Glu Ile Glu Thr 
        195                 200                 205             


Ser Lys Lys Thr His Leu Tyr Glu Leu Met Glu Thr Glu Asp His Tyr 
    210                 215                 220                 


Pro Phe Tyr Leu Asp Pro Met Glu Thr Pro Asn Leu Tyr Phe Thr Arg 
225                 230                 235                 240 


Asp Pro Ala Ala Ser Val Gly Asp Gly Leu Thr Ile Asn Lys Met Glu 
                245                 250                 255     


Thr Arg Glu Pro Ala Arg Arg Arg Glu Ser Leu Phe Met Glu Thr Glu 
            260                 265                 270         


Tyr Ile Ile Lys Tyr His Pro Arg Phe Glu Lys His Asn Val Pro Ile 
        275                 280                 285             


Trp Leu Asp Arg Asp Tyr Lys Phe Pro Ile Glu Gly Gly Asp Glu Leu 
    290                 295                 300                 


Ile Leu Asn Glu Glu Thr Ile Ala Ile Gly Val Ser Ala Arg Thr Ser 
305                 310                 315                 320 


Ala Lys Ala Ile Glu Arg Leu Ala Lys Asn Leu Phe Ser Arg Gln Asn 
                325                 330                 335     


Lys Ile Lys Lys Val Leu Ala Ile Glu Ile Pro Lys Cys Arg Ala Phe 
            340                 345                 350         


Met Glu Thr His Leu Asp Thr Val Phe Thr Met Glu Thr Val Asp Tyr 
        355                 360                 365             


Asp Lys Phe Thr Ile His Pro Ala Ile Gln Gly Pro Lys Gly Asn Met 
    370                 375                 380                 


Glu Thr Asn Ile Tyr Ile Leu Glu Lys Gly Ser Asp Glu Glu Thr Leu 
385                 390                 395                 400 


Lys Ile Thr His Arg Thr Ser Leu Met Glu Thr Glu Ala Leu Lys Glu 
                405                 410                 415     


Val Leu Gly Leu Ser Glu Leu Val Leu Ile Pro Cys Gly Gly Gly Asp 
            420                 425                 430         


Val Ile Ala Ser Ala Arg Glu Gln Trp Asn Asp Gly Ser Asn Thr Leu 
        435                 440                 445             


Ala Ile Ala Pro Gly Val Val Val Thr Tyr Asp Arg Asn Tyr Val Ser 
    450                 455                 460                 


Asn Thr Leu Leu Arg Glu His Gly Ile Glu Val Ile Glu Val Leu Ser 
465                 470                 475                 480 


Ser Glu Leu Ser Arg Gly Arg Gly Gly Pro Arg Cys Met Glu Thr Ser 
                485                 490                 495     


Met Glu Thr Pro Ile Val Arg Lys Asp Ile 
            500                 505     


<210>  42
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD-Intein-CBD, synthesized in lab

<400>  42

Met Ala Gln His Asp Glu Ala Val Asp Ala Asn Ser Leu Ala Glu Ala 
1               5                   10                  15      


Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr 
            20                  25                  30          


Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala 
        35                  40                  45              


Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro Glu Phe Leu Glu Gly Ser 
    50                  55                  60                  


Ser Cys Ile Thr Gly Asp Ala Leu Val Ala Leu Pro Glu Gly Glu Ser 
65                  70                  75                  80  


Val Arg Ile Ala Asp Ile Val Pro Gly Ala Arg Pro Asn Ser Asp Asn 
                85                  90                  95      


Ala Ile Asp Leu Lys Val Leu Asp Arg His Gly Asn Pro Val Leu Ala 
            100                 105                 110         


Asp Arg Leu Phe His Ser Gly Glu His Pro Val Tyr Thr Val Arg Thr 
        115                 120                 125             


Val Glu Gly Leu Arg Val Thr Gly Thr Ala Asn His Pro Leu Leu Cys 
    130                 135                 140                 


Leu Val Asp Val Ala Gly Val Pro Thr Leu Leu Trp Lys Leu Ile Asp 
145                 150                 155                 160 


Glu Ile Lys Pro Gly Asp Tyr Ala Val Ile Gln Arg Ser Ala Phe Ser 
                165                 170                 175     


Val Asp Cys Ala Gly Phe Ala Arg Gly Lys Pro Glu Phe Ala Pro Thr 
            180                 185                 190         


Thr Tyr Thr Val Gly Val Pro Gly Leu Val Arg Phe Leu Glu Ala His 
        195                 200                 205             


His Arg Asp Pro Asp Ala Gln Ala Ile Ala Asp Glu Leu Thr Asp Gly 
    210                 215                 220                 


Arg Phe Tyr Tyr Ala Lys Val Ala Ser Val Thr Asp Ala Gly Val Gln 
225                 230                 235                 240 


Pro Val Tyr Ser Leu Arg Val Asp Thr Ala Asp His Ala Phe Ile Thr 
                245                 250                 255     


Asn Gly Phe Val Ser His Ala Thr Gly Leu Thr Gly Leu Asn Ser Gly 
            260                 265                 270         


Leu Thr Thr Asn Pro Gly Val Ser Ala Trp Gln Val Asn Thr Ala Tyr 
        275                 280                 285             


Thr Ala Gly Gln Leu Val Thr Tyr Asn Gly Lys Thr Tyr Lys Cys Leu 
    290                 295                 300                 


Gln Pro His Thr Ser Leu Ala Gly Trp Glu Pro Ser Asn Val Pro Ala 
305                 310                 315                 320 


Leu Trp Gln Leu Gln Gly Asp Pro Ile Thr Ile Thr Ile Thr Lys 
                325                 330                 335 


<210>  43
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBD-Intein-ADI, synthesized in lab

<400>  43

Met Lys Ile Glu Glu Gly Lys Leu Thr Asn Pro Gly Val Ser Ala Trp 
1               5                   10                  15      


Gln Val Asn Thr Ala Tyr Thr Ala Gly Gln Leu Val Thr Tyr Asn Gly 
            20                  25                  30          


Lys Thr Tyr Lys Cys Leu Gln Pro His Thr Ser Leu Ala Gly Trp Glu 
        35                  40                  45              


Pro Ser Asn Val Pro Ala Leu Trp Gln Leu Gln Asn Asn Gly Asn Asn 
    50                  55                  60                  


Gly Leu Glu Leu Arg Glu Ser Gly Ala Ile Ser Gly Asp Ser Leu Ile 
65                  70                  75                  80  


Ser Leu Ala Ser Thr Gly Lys Arg Val Ser Ile Lys Asp Leu Leu Asp 
                85                  90                  95      


Glu Lys Asp Phe Glu Ile Trp Ala Ile Asn Glu Gln Thr Met Lys Leu 
            100                 105                 110         


Glu Ser Ala Lys Val Ser Arg Val Phe Cys Thr Gly Lys Lys Leu Val 
        115                 120                 125             


Tyr Ile Leu Lys Thr Arg Leu Gly Arg Thr Ile Lys Ala Thr Ala Asn 
    130                 135                 140                 


His Arg Phe Leu Thr Ile Asp Gly Trp Lys Arg Leu Asp Glu Leu Ser 
145                 150                 155                 160 


Leu Lys Glu His Ile Ala Leu Pro Arg Lys Leu Glu Ser Ser Ser Leu 
                165                 170                 175     


Gln Leu Ser Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp 
            180                 185                 190         


Asp Ser Ile Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp 
        195                 200                 205             


Leu Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val 
    210                 215                 220                 


His Asn Cys Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr 
225                 230                 235                 240 


Ser Glu Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg 
                245                 250                 255     


Glu Ile Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Cys Phe Ser 
            260                 265                 270         


Ala Ile Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val 
        275                 280                 285             


Ala Glu Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile Asp Leu 
    290                 295                 300                 


Val Ala Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu 
305                 310                 315                 320 


Ile Glu Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His 
                325                 330                 335     


Lys Val Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu 
            340                 345                 350         


Leu Val Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile 
        355                 360                 365             


Glu Ala Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe 
    370                 375                 380                 


Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr 
385                 390                 395                 400 


Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val 
                405                 410                 415     


Phe Ser Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro 
            420                 425                 430         


Ser Leu Lys Leu Ser Ile Ala Gly Gly Asp Val Phe Ile Tyr Asn Asn 
        435                 440                 445             


Asp Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val 
    450                 455                 460                 


Thr Leu Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys 
465                 470                 475                 480 


Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu 
                485                 490                 495     


Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro 
            500                 505                 510         


Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly 
        515                 520                 525             


Gly Ala Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu 
    530                 535                 540                 


Leu Gln Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly 
545                 550                 555                 560 


Glu Gly Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly 
                565                 570                 575     


Thr Asn Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg 
            580                 585                 590         


Asn Glu Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu 
        595                 600                 605             


Pro Phe His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys 
    610                 615                 620                 


Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
625                 630                 635     


<210>  44
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-ABD-PolyN-ADI-DNA, synthesized in lab

<400>  44
atgcatcatc accatcacca tgatgaagcc gtggatgcga attccttagc tgaagctaaa       60

gtcttagcta acagagaact tgacaaatat ggagtaagtg actattacaa gaacctaatc      120

aacaatgcca aaactgttga aggtgtaaaa gcactgatag atgaaatttt agctgcatta      180

ccttcgggta gtaacaacaa taataacaat ggtagcggcg gttctgtatt tgacagtaaa      240

tttaaaggaa ttcacgttta ttcagaaatt ggtgaattag aatcagttct agttcacgaa      300

ccaggacgcg aaattgacta tattacacca gctagactag atgaattatg cttctcagct      360

atcttagaaa gccacgatgc tagaaaagaa cacaaacaat tcgtagcaga attaaaagca      420

aacgacatca atgttgttga attaattgat ttagttgctg aaacatatga tttagcatca      480

caagaagcta aagacaaatt aatcgaagaa tttttagaag actcagaacc agttctatca      540

gaagaacaca aagtagttgt aagaaacttc ttaaaagcta aaaaaacatc aagagaatta      600

gtagaaatca tgatggcagg gatcacaaaa tacgatttag gtatcgaagc agatcacgaa      660

ttaatcgttg acccaatgcc aaacctatac ttcacacgtg acccatttgc atcagtaggt      720

aatggtgtaa caatccacta catgcgttac aaagttagac aacgtgaaac attattctca      780

agatttgtat tctcaaatca ccctaaacta attaacactc catggtacta cgacccttca      840

ctaaaattat caatcgcagg tggggacgta tttatctaca acaatgacac attagtagtt      900

ggtgtttctg aaagaactga cttacaaaca gttactttat tagctaaaaa cattgttgct      960

aataaagaat ctgaattcaa acgtattgtt gcaattaacg ttccaaaatg gacaaactta     1020

atgcacttag acacatggct aacaatgtta gacaaggaca aattcctata ctcaccaatc     1080

gctaatgacg tatttaaatt ctgggattat gacttagtaa acggtggagc agaaccacaa     1140

ccagttgaaa acggattacc tctagaagga ttattacaat caatcattaa caaaaaacca     1200

gttttaattc ctatcgcagg tgaaggtgct tcacaaatgg aaatcgaaag agaaacacac     1260

ttcgatggta caaactactt agcaattaga ccaggtgttg taattggtta ctcacgtaac     1320

gaaaaaacaa acgctgctct agaagctgca ggcattaaag ttcttccatt ccacggtaac     1380

caattatcat taggtatggg taacgctcgt tgtatgtcaa tgcctttatc acgtaaagat     1440

gttaagtggt aa                                                         1452


<210>  45
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-ABD-PolyN-bcADI-DNA, synthesized in lab

<400>  45
atgggtcatc atcaccatca ccatgatgaa gccgtggatg cgaacagctt agctgaagct       60

aaagtcttag ctaacagaga acttgacaaa tatggagtaa gtgactatta caagaaccta      120

atcaacaatg ccaaaactgt tgaaggtgta aaagcactga tagatgaaat tttagctgca      180

ttaccttcgg gtagtaacaa caataataac aatggtagcg gcggtaaaca tccgatacat      240

gttacttcag aaattgggga attacaaacg gttttattaa aacgaccggg taaagaagtg      300

gaaaacttga cgccagatta tttgcagcaa ttattatttg acgatattcc atacctacca      360

attattcaaa aagagcatga ttattttgca caaacgttac gcaatcgggg tgttgaagtt      420

ctttatttag aaaaactagc cgctgaggcg ttagtagata aaaaacttcg agaagaattt      480

gttgatcgta ttttaaaaga aggacaggcc gacgtaaatg ttgcacatca aactttaaaa      540

gaatatttac tttccttttc aaatgaagaa ttaattcaaa aaattatggg cggtgtacgg      600

aaaaacgaaa ttgaaacaag taagaagaca catttatatg aattaatgga agatcattat      660

ccgttttact tagatccaat gcctaattta tattttactc gtgatccagc agctagcgtg      720

ggcgatggct taacgataaa taagatgaga gaaccagcgc gtagacgtga atcattattc      780

atggagtaca tcattaaata tcatccaaga tttgaaaaac ataatgtacc aatctggtta      840

gatcgtgatt ataaatttcc aattgaaggt ggcgacgagc taattttaaa tgaagaaaca      900

attgcgattg gagtatctgc tcgtacttca gctaaagcaa ttgaacgttt agcaaaaaat      960

ctctttagcc gacaaaataa aattaagaaa gtgttagcaa tagaaattcc aaaatgccga     1020

gcatttatgc atttagatac agtatttaca atggttgatt atgataagtt tacaattcac     1080

ccagctattc aagggccaaa agggaatatg aatatttata ttttagaaaa aggatcagat     1140

gaggaaactc ttaaaattac acatcgtact tctttaatgg aagcattaaa agaggtatta     1200

ggcttaagtg aattagttct tattccatgt ggaggaggag atgtaattgc ttctgctcgt     1260

gaacaatgga atgatggctc gaacacatta gcaatcgcgc caggtgtagt tgttacatat     1320

gatcgcaact atgtatccaa tacgttatta cgggaacacg gtatagaagt gattgaggtg     1380

ctaagttcag aattatctcg tggtcgtggg ggtccacgtt gcatgagtat gccaattgtt     1440

cgtaaagata tttaa                                                      1455


<210>  46
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD without Linker, synthesized in lab

<400>  46

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu 
            20                  25                  30          


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  47
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD with Linker, synthesized in lab

<400>  47

Ala Gln His Asp Glu Ala Val Asp Ala Asn Ser Leu Ala Glu Ala Lys 
1               5                   10                  15      


Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 
            20                  25                  30          


Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala Leu 
        35                  40                  45              


Ile Asp Glu Ile Leu Ala Ala Leu Pro 
    50                  55          


<210>  48
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD1 without Linker, synthesized in lab

<400>  48

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Phe Tyr Lys Arg Leu Ile Asn Lys Ala Lys Thr Val Glu 
            20                  25                  30          


Gly Val Glu Ala Leu Lys Leu His Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  49
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD1 with Linker, synthesized in lab

<400>  49

Gly Ser His His His His His His Ala Asn Ser Leu Ala Glu Ala Lys 
1               5                   10                  15      


Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Phe Tyr 
            20                  25                  30          


Lys Arg Leu Ile Asn Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu 
        35                  40                  45              


Lys Leu His Ile Leu Ala Ala Leu Pro 
    50                  55          


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1, synthesized in lab

<400>  50

Gly Ser His His His His His His Ala Asn Ser 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2, synthesized in lab

<400>  51

Ala Gln His Asp Glu Ala Val Asp Ala Asn Ser 
1               5                   10      


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3, synthesized in lab

<400>  52

Asp Glu Ala Val Asp Ala Asn Ser 
1               5               


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 5, synthesized in lab

<400>  53

Gly Ser Gly Gly 
1               


