                         SEQUENCE LISTING

<110>  Oxyrane UK Ltd
 
<120>  PRODUCTION OF CATALYTICALLY ACTIVE TYPE I SULFATASE

<130>  P1363PC00

<150>  61/773,034
<151>  2013-03-05

<150>  61/790,530
<151>  2013-03-15

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDEL tag

<400>  1

His Asp Glu Leu 
1               


<210>  2
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDEL tag coding sequence

<400>  2
cacgacgagc tg                                                           12


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDEL tag

<400>  3

Lys Asp Glu Leu 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDEL tag

<400>  4

Asp Asp Glu Leu 
1               


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader/Signal sequence

<400>  5

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala 
    


<210>  6
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for Lip2 Leader/Signal Sequence

<400>  6
atgaagctgt ctactattct ctttactgcc tgcgctactc tcgccgctgc t                51


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His6 tag

<400>  7

His His His His His His 
1               5       


<210>  8
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His6 tag coding sequence

<400>  8
caccaccacc accaccac                                                     18


<210>  9
<211>  341
<212>  PRT
<213>  Homo sapiens mature FGE protein

<400>  9

Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala Gly Ser Leu Ala Gly Ser 
1               5                   10                  15      


Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ala His Gly Ser Ser Ala 
            20                  25                  30          


Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly Pro Val Pro 
        35                  40                  45              


Gly Glu Arg Gln Leu Ala His Ser Lys Met Val Pro Ile Pro Ala Gly 
    50                  55                  60                  


Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly Glu 
65                  70                  75                  80  


Ala Pro Ala Arg Arg Val Thr Ile Asp Ala Phe Tyr Met Asp Ala Tyr 
                85                  90                  95      


Glu Val Ser Asn Thr Glu Phe Glu Lys Phe Val Asn Ser Thr Gly Tyr 
            100                 105                 110         


Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly Met 
        115                 120                 125             


Leu Ser Glu Gln Val Lys Thr Asn Ile Gln Gln Ala Val Ala Ala Ala 
    130                 135                 140                 


Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu Gly 
145                 150                 155                 160 


Pro Asp Ser Thr Ile Leu His Arg Pro Asp His Pro Val Leu His Val 
                165                 170                 175     


Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg Leu 
            180                 185                 190         


Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu His Asn 
        195                 200                 205             


Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln His Tyr 
    210                 215                 220                 


Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Gly Glu Asp 
225                 230                 235                 240 


Gly Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly Tyr 
                245                 250                 255     


Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp Trp 
            260                 265                 270         


Trp Thr Val His His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly Pro 
        275                 280                 285             


Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys His 
    290                 295                 300                 


Arg Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn Thr 
305                 310                 315                 320 


Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp Arg 
                325                 330                 335     


Leu Pro Thr Met Asp 
            340     


<210>  10
<211>  1023
<212>  DNA
<213>  Homo sapiens coding sequence of mature FGE protein

<400>  10
tcccaggaag ccggcaccgg agctggtgct ggttctctgg ctggatcgtg cggatgtggc       60

actcctcagc gacctggagc tcatggctcc tctgccgctg cccaccgata ctctcgagag      120

gctaacgctc ctggtcctgt ccccggagag cgacagctcg cccattctaa gatggtgcct      180

atccccgctg gagttttcac catgggcact gacgatcctc agatcaagca ggacggagag      240

gctcctgctc gacgagtgac cattgacgcc ttttacatgg atgcttacga ggtttcgaac      300

actgagttcg agaagtttgt caactctacc ggatacctga ctgaggccga gaagttcggt      360

gactcgttcg tgtttgaggg aatgctctcc gagcaggtca agaccaacat ccagcaggct      420

gtggctgccg ctccttggtg gctgcccgtt aagggagcta actggcgaca ccctgaggga      480

cctgactcca ccattctgca ccgacctgat catcccgtcc tccacgtgtc ttggaacgac      540

gccgttgctt actgtacctg ggctggcaag cgactgccta ctgaggctga gtgggagtac      600

tcctgccgag gcggtctgca taaccgactc ttcccttggg gcaacaagct ccagcccaag      660

ggtcagcact acgccaacat ctggcagggc gagtttcctg tgaccaacac tggagaggac      720

ggattccagg gcaccgctcc tgttgatgct tttcccccta acggttacgg actgtacaac      780

attgtcggta acgcttggga gtggacctct gactggtgga ctgttcacca ttcggtcgag      840

gagaccctca accccaaggg ccctccctct ggcaaggatc gagtcaagaa gggaggctcc      900

tacatgtgcc accgatctta ctgttaccga taccgatgcg ccgctcgatc ccagaacacc      960

cccgactcgt ccgcctctaa cctgggcttc cgatgtgccg ctgaccgact gcctactatg     1020

gac                                                                   1023


<210>  11
<211>  314
<212>  PRT
<213>  Streptomyces coelicolor FGE mature protein

<400>  11

Met Ala Val Ala Ala Pro Ser Pro Ala Ala Ala Ala Glu Pro Gly Pro 
1               5                   10                  15      


Ala Ala Arg Pro Arg Ser Thr Arg Gly Gln Val Arg Leu Pro Gly Gly 
            20                  25                  30          


Glu Phe Ala Met Gly Asp Ala Phe Gly Glu Gly Tyr Pro Ala Asp Gly 
        35                  40                  45              


Glu Thr Pro Val His Thr Val Arg Leu Arg Pro Phe His Ile Asp Glu 
    50                  55                  60                  


Thr Ala Val Thr Asn Ala Arg Phe Ala Ala Phe Val Lys Ala Thr Gly 
65                  70                  75                  80  


His Val Thr Asp Ala Glu Arg Phe Gly Ser Ser Ala Val Phe His Leu 
                85                  90                  95      


Val Val Ala Ala Pro Asp Ala Asp Val Leu Gly Ser Ala Ala Gly Ala 
            100                 105                 110         


Pro Trp Trp Ile Asn Val Arg Gly Ala His Trp Arg Arg Pro Glu Gly 
        115                 120                 125             


Ala Arg Ser Asp Ile Thr Gly Arg Pro Asn His Pro Val Val His Val 
    130                 135                 140                 


Ser Trp Asn Asp Ala Thr Ala Tyr Ala Arg Trp Ala Gly Lys Arg Leu 
145                 150                 155                 160 


Pro Thr Glu Ala Glu Trp Glu Tyr Ala Ala Arg Gly Gly Leu Ala Gly 
                165                 170                 175     


Arg Arg Tyr Ala Trp Gly Asp Glu Leu Thr Pro Gly Gly Arg Trp Arg 
            180                 185                 190         


Cys Asn Ile Trp Gln Gly Arg Phe Pro His Val Asn Thr Ala Glu Asp 
        195                 200                 205             


Gly His Leu Ser Thr Ala Pro Val Lys Ser Tyr Arg Pro Asn Gly His 
    210                 215                 220                 


Gly Leu Trp Asn Thr Ala Gly Asn Val Trp Glu Trp Cys Ser Asp Trp 
225                 230                 235                 240 


Phe Ser Pro Thr Tyr Tyr Ala Glu Ser Pro Thr Val Asp Pro His Gly 
                245                 250                 255     


Pro Gly Thr Gly Ala Ala Arg Val Leu Arg Gly Gly Ser Tyr Leu Cys 
            260                 265                 270         


His Asp Ser Tyr Cys Asn Arg Tyr Arg Val Ala Ala Arg Ser Ser Asn 
        275                 280                 285             


Thr Pro Asp Ser Ser Ser Gly Asn Leu Gly Phe Arg Cys Ala Asn Asp 
    290                 295                 300                 


Ala Asp Leu Thr Ser Gly Ser Ala Ala Glu 
305                 310                 


<210>  12
<211>  942
<212>  DNA
<213>  Streptomyces coelicolor FGE protein coding sequence

<400>  12
atggctgttg ctgctccctc gcctgctgct gctgccgagc ccggtcctgc tgctcgaccc       60

cgatctaccc gaggacaggt gcgactgcct ggcggtgagt tcgctatggg cgacgctttt      120

ggagagggat accctgccga tggagagacc cctgtgcaca ctgttcgact ccgacccttc      180

catatcgacg agaccgctgt tactaacgcc cgattcgccg cttttgtcaa ggctaccgga      240

cacgtgactg atgccgagcg attcggctcc tctgctgttt ttcatctggt cgtggccgct      300

cccgacgctg atgtcctggg ctccgctgct ggagctcctt ggtggatcaa cgttcgaggt      360

gcccactggc gacgacctga gggagctcga tctgacatta ccggtcgacc caaccaccct      420

gttgtccatg tctcctggaa cgatgctacc gcttacgctc gatgggctgg aaagcgactg      480

cctactgagg ctgagtggga gtacgctgct cgaggcggcc tggctggtcg acgatacgct      540

tggggagacg agctcacccc cggtggacga tggcgatgca acatttggca gggacgattc      600

cctcacgtca acaccgccga ggacggccat ctgtccactg ctcccgtgaa gtcttaccga      660

cctaacggtc acggactctg gaacaccgcc ggtaacgtct gggagtggtg ttctgactgg      720

ttttcgccca cctactacgc cgagtctcct actgtcgacc cccacggacc tggtactgga      780

gctgctcgag ttctgcgagg cggttcgtac ctctgccatg actcctactg taaccgatac      840

cgagtggccg ctcgatcgtc caacaccccc gactcttcgt ccggcaacct cggtttccga      900

tgcgccaacg atgctgacct gacttctgga tctgccgctg ag                         942


<210>  13
<211>  402
<212>  PRT
<213>  Hemicentrotus pulcherrimus FGE mature protein

<400>  13

Glu Asn Glu Asp Ile Asn Gln Asn Ile Ser Pro Thr Gln Ser His Thr 
1               5                   10                  15      


Thr Ala Thr Thr Glu Glu Glu Leu Ala Glu Ala Arg Gly Glu Glu Ile 
            20                  25                  30          


Asp Ser Asp Pro Thr Ser Glu Gly Ser Gly Ala Gly Glu Gly Cys Gly 
        35                  40                  45              


Cys Gly Ser Ser Ala Leu Asn Arg Asn His Asp Glu Asp Ala Leu Gly 
    50                  55                  60                  


Leu Ala Leu Glu Glu Asn Leu His Asp His Val Gln Glu Gly Ala Ala 
65                  70                  75                  80  


Leu Lys Tyr Ser Arg Glu Ala Asn Asp Pro Ile Ser Met Asp His Pro 
                85                  90                  95      


Glu Ala Asn Val Gly Ala Phe Pro Arg Thr Asn Gln Met Asn Phe Ile 
            100                 105                 110         


Glu Gly Gly Thr Phe Arg Met Gly Thr Asp Lys Ala Lys Ile Tyr Leu 
        115                 120                 125             


Asp Gly Glu Ser Pro Ser Arg Leu Val Thr Leu Asp Pro Tyr Tyr Phe 
    130                 135                 140                 


Asp Val Tyr Glu Val Ser Asn Ser Glu Phe Glu Leu Phe Val Asn Thr 
145                 150                 155                 160 


Thr Ser Tyr Ile Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Leu 
                165                 170                 175     


Glu Ala Arg Ile Ser Glu Glu Val Lys Lys Asp Ile Ser Gln Val Val 
            180                 185                 190         


Ala Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Glu Trp Arg His 
        195                 200                 205             


Pro Glu Gly Pro Asp Ser Ser Ile Ser Ser Arg Met Asp His Pro Val 
    210                 215                 220                 


Thr His Ile Ser Trp Asn Asp Ala Thr Ala Tyr Cys Gln Trp Ala Gly 
225                 230                 235                 240 


Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Asn Ala Ala Arg Gly Gly 
                245                 250                 255     


Leu Asn Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Met Pro Lys Asp 
            260                 265                 270         


His His Arg Val Asn Ile Trp Gln Gly Glu Phe Pro Lys Val Asn Thr 
        275                 280                 285             


Ala Glu Asp Gly Tyr Glu Gly Thr Cys Pro Val Thr Ala Phe Glu Pro 
    290                 295                 300                 


Asn Gly Tyr Gly Leu Tyr Asn Thr Val Gly Asn Ala Trp Glu Trp Val 
305                 310                 315                 320 


Ala Asp Trp Trp Thr Thr Val His Ser Pro Glu Ser Gln Asn Asn Pro 
                325                 330                 335     


Val Gly Pro Asp Glu Gly Thr Asp Lys Val Lys Lys Gly Gly Ser Tyr 
            340                 345                 350         


Met Cys His Ile Ser Tyr Cys Tyr Arg Tyr Arg Cys Glu Ala Arg Ser 
        355                 360                 365             


Gln Asn Ser Pro Asp Ser Ser Ala Cys Asn Leu Gly Phe Arg Cys Ala 
    370                 375                 380                 


Ala Thr Asn Leu Pro Glu Asp Ile Pro Cys Ser Asn Cys Asn Asp Ser 
385                 390                 395                 400 


Thr Pro 
        


<210>  14
<211>  1206
<212>  DNA
<213>  Hemicentrotus pulcherrimus FGE protein coding sequence

<400>  14
gagaacgagg acatcaacca gaacatttcg cctacccagt ctcacaccac tgccaccact       60

gaggaagagc tcgctgaggc ccgaggcgag gagatcgact ccgatcccac ctctgagggc      120

tctggtgctg gagagggatg cggttgtggc tcctctgccc tgaaccgaaa ccacgacgag      180

gatgctctgg gtctcgccct ggaggagaac ctccacgacc atgttcagga aggcgccgct      240

ctgaagtact cgcgagaggc taacgacccc atttctatgg atcatcctga ggctaacgtc      300

ggtgccttcc cccgaaccaa ccagatgaac ttcatcgagg gcggtacctt tcgaatggga      360

actgacaagg ccaagatcta cctggatggt gaatctcctt cccgactggt gaccctggac      420

ccttactact ttgatgttta cgaggtctct aactcggagt tcgagctctt tgttaacacc      480

acttcttaca tcaccgaggc tgagaagttc ggtgactcct ttgtgctgga ggcccgaatc      540

tctgaggaag tcaagaagga tatttctcag gtggtggctg ctgctccttg gtggctcccc      600

gtcaagggtg ctgagtggcg acaccctgag ggtcctgact cgtccatctc ttcgcgaatg      660

gatcaccccg tgacccatat ttcctggaac gacgctactg cctactgtca gtgggctgga      720

aagcgactcc ctaccgaggc tgagtgggag aacgctgctc gaggcggcct caacaaccga      780

ctgttcccct ggggcaacaa gctgatgcct aaggaccacc atcgagttaa catttggcag      840

ggagagttcc ccaaggtcaa caccgctgag gacggatacg agggcacctg ccccgtgact      900

gcctttgagc ctaacggcta cggtctgtac aacactgtgg gaaacgcttg ggagtgggtt      960

gccgactggt ggaccactgt ccactcgccc gagtcccaga acaaccccgt cggtcctgac     1020

gagggaaccg ataaggtcaa gaagggcggc tcctacatgt gccatatctc ttactgttac     1080

cgataccgat gcgaggctcg atctcagaac tcgcccgact cctctgcctg taacctcggc     1140

ttccgatgcg ctgccaccaa cctgcctgag gacattcctt gttctaactg taacgattcc     1200

actccc                                                                1206


<210>  15
<211>  351
<212>  PRT
<213>  Bos Taurus FGE coding sequence mature sequence

<400>  15

Ala Gly Gly Glu Glu Ala Gly Pro Glu Ala Gly Ala Pro Ser Leu Val 
1               5                   10                  15      


Gly Ser Cys Gly Cys Gly Asn Pro Gln Arg Pro Gly Ala Gln Gly Ser 
            20                  25                  30          


Ser Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly Ser 
        35                  40                  45              


Val Pro Gly Gly Arg Pro Ser Pro Pro Thr Lys Met Val Pro Ile Pro 
    50                  55                  60                  


Ala Gly Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp 
65                  70                  75                  80  


Gly Glu Ala Pro Ala Arg Arg Val Ala Ile Asp Ala Phe Tyr Met Asp 
                85                  90                  95      


Ala Tyr Glu Val Ser Asn Ala Glu Phe Glu Lys Phe Val Asn Ser Thr 
            100                 105                 110         


Gly Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu 
        115                 120                 125             


Gly Met Leu Ser Glu Gln Val Lys Ser Asp Ile Gln Gln Ala Val Ala 
    130                 135                 140                 


Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro 
145                 150                 155                 160 


Glu Gly Pro Asp Ser Thr Val Leu His Arg Pro Asp His Pro Val Leu 
                165                 170                 175     


His Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys 
            180                 185                 190         


Arg Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu 
        195                 200                 205             


Gln Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln 
    210                 215                 220                 


His Tyr Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Gly 
225                 230                 235                 240 


Glu Asp Gly Phe Arg Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn 
                245                 250                 255     


Gly Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser 
            260                 265                 270         


Asp Trp Trp Thr Val His His Ser Ala Glu Glu Thr Ile Asn Pro Lys 
        275                 280                 285             


Gly Pro Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met 
    290                 295                 300                 


Cys His Lys Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln 
305                 310                 315                 320 


Asn Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala 
                325                 330                 335     


Asp His Leu Pro Thr Thr Gly Ala Asp His Leu Pro Thr Thr Gly 
            340                 345                 350     


<210>  16
<211>  1029
<212>  DNA
<213>  Bos Taurus FGE protein coding sequence

<400>  16
gccggcggcg aggaagccgg acctgaggcc ggcgctccct ctctggttgg atcgtgtgga       60

tgtggaaacc cccagcgacc tggcgctcag ggttcctctg ccgctgccca ccgatactct      120

cgagaggcta acgctcctgg ctctgtccct ggaggccgac cctcgccccc taccaagatg      180

gttcccatcc ctgccggcgt cttcaccatg ggtactgacg atcctcagat caagcaggac      240

ggagaggctc ctgctcgacg agtggctatt gacgcttttt acatggatgc ctacgaggtc      300

tctaacgctg agttcgagaa gtttgtgaac tcgaccggat acctgactga ggccgagaag      360

ttcggagact ccttcgtttt tgagggcatg ctctccgagc aggtgaagtc tgatattcag      420

caggctgttg ctgccgctcc ttggtggctg cctgtcaagg gagctaactg gcgacatccc      480

gagggtcctg actccaccgt gctgcaccga cccgatcatc ctgtcctcca cgtgtcttgg      540

aacgacgccg tcgcttactg tacctgggct ggcaagcgac tgcctactga ggctgagtgg      600

gagtactctt gccgaggtgg actgcagaac cgactcttcc cttggggtaa caagctccag      660

cccaagggac agcactacgc caacatctgg cagggagagt ttcctgtgac caacactggt      720

gaagacggct tccgaggcac cgctcctgtt gatgcttttc cccctaacgg ttacggactc      780

tacaacatcg ttggcaacgc ctgggagtgg acctccgact ggtggactgt ccaccattct      840

gctgaggaga ctattaaccc caagggtccc ccttctggaa aggatcgagt gaagaagggc      900

ggttcgtaca tgtgccacaa gtcctactgt taccgatacc gatgcgccgc tcgatcgcag      960

aacacccccg actcgtccgc ctccaacctg ggattccgat gtgccgctga ccacctgcct     1020

actactgga                                                             1029


<210>  17
<211>  299
<212>  PRT
<213>  Mycobacterium tuberculosis FGE mature sequence

<400>  17

Met Leu Thr Glu Leu Val Asp Leu Pro Gly Gly Ser Phe Arg Met Gly 
1               5                   10                  15      


Ser Thr Arg Phe Tyr Pro Glu Glu Ala Pro Ile His Thr Val Thr Val 
            20                  25                  30          


Arg Ala Phe Ala Val Glu Arg His Pro Val Thr Asn Ala Gln Phe Ala 
        35                  40                  45              


Glu Phe Val Ser Ala Thr Gly Tyr Val Thr Val Ala Glu Gln Pro Leu 
    50                  55                  60                  


Asp Pro Gly Leu Tyr Pro Gly Val Asp Ala Ala Asp Leu Cys Pro Gly 
65                  70                  75                  80  


Ala Met Val Phe Cys Pro Thr Ala Gly Pro Val Asp Leu Arg Asp Trp 
                85                  90                  95      


Arg Gln Trp Trp Asp Trp Val Pro Gly Ala Cys Trp Arg His Pro Phe 
            100                 105                 110         


Gly Arg Asp Ser Asp Ile Ala Asp Arg Ala Gly His Pro Val Val Gln 
        115                 120                 125             


Val Ala Tyr Pro Asp Ala Val Ala Tyr Ala Arg Trp Ala Gly Arg Arg 
    130                 135                 140                 


Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ala Ala Arg Gly Gly Thr Thr 
145                 150                 155                 160 


Ala Thr Tyr Ala Trp Gly Asp Gln Glu Lys Pro Gly Gly Met Leu Met 
                165                 170                 175     


Ala Asn Thr Trp Gln Gly Arg Phe Pro Tyr Arg Asn Asp Gly Ala Leu 
            180                 185                 190         


Gly Trp Val Gly Thr Ser Pro Val Gly Arg Phe Pro Ala Asn Gly Phe 
        195                 200                 205             


Gly Leu Leu Asp Met Ile Gly Asn Val Trp Glu Trp Thr Thr Thr Glu 
    210                 215                 220                 


Phe Tyr Pro His His Arg Ile Asp Pro Pro Ser Thr Ala Cys Cys Ala 
225                 230                 235                 240 


Pro Val Lys Leu Ala Thr Ala Ala Asp Pro Thr Ile Ser Gln Thr Leu 
                245                 250                 255     


Lys Gly Gly Ser His Leu Cys Ala Pro Glu Tyr Cys His Arg Tyr Arg 
            260                 265                 270         


Pro Ala Ala Arg Ser Pro Gln Ser Gln Asp Thr Ala Thr Thr His Ile 
        275                 280                 285             


Gly Phe Arg Cys Val Ala Asp Pro Val Ser Gly 
    290                 295                 


<210>  18
<211>  897
<212>  DNA
<213>  Mycobacterium tuberculosis FGE protein coding sequence

<400>  18
atgctgactg agctggttga cctccctggt ggttccttcc gaatgggatc tacccgattt       60

taccccgagg aggcccctat ccacactgtt accgtccgag ccttcgctgt cgagcgacat      120

cccgtgacca acgctcagtt cgccgagttt gtttcggcta ctggctacgt gaccgttgct      180

gagcagcctc tggaccctgg actctaccct ggagtcgacg ctgctgatct gtgccctggc      240

gctatggtct tctgtcctac cgctggtcct gtggacctcc gagattggcg acagtggtgg      300

gactgggtcc ctggtgcttg ctggcgacac ccttttggac gagactccga tattgctgac      360

cgagctggac atcctgtcgt gcaggtggct taccctgatg ccgttgctta cgctcgatgg      420

gctggtcgac gactgcctac tgaggctgag tgggagtacg ctgctcgagg aggtaccact      480

gctacctacg cttggggtga ccaggagaag cctggaggca tgctgatggc taacacctgg      540

cagggacgat tcccttaccg aaacgatgga gccctcggct gggttggtac ctcccctgtc      600

ggacgattcc ctgctaacgg ctttggtctg ctcgacatga tcggcaacgt gtgggagtgg      660

accactaccg agttttaccc ccaccatcga attgaccccc cttctactgc ttgctgtgct      720

cctgttaagc tcgctaccgc tgctgatcct actatctcgc agaccctgaa gggtggctcc      780

cacctctgcg ctcccgagta ctgtcatcga taccgacccg ccgctcgatc ccctcagtct      840

caggacaccg ccactaccca cattggtttt cgatgtgttg ctgaccctgt ttcgggc         897


<210>  19
<211>  525
<212>  PRT
<213>  human iduronate sulfatase mature sequence

<400>  19

Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
        515                 520                 525 


<210>  20
<211>  1575
<212>  DNA
<213>  human iduronate sulfatase protein coding sequence

<400>  20
tctgagaccc aggctaactc gactactgac gctctgaacg tgctcctgat tattgttgac       60

gacctgcgac cctccctcgg ttgctacggt gacaagctgg tgcgatctcc caacatcgac      120

cagctcgctt ctcactcgct gctcttccag aacgcctttg ctcagcaggc cgtctgcgct      180

ccttcgcgag tgtccttcct gaccggacga cgacccgaca ccactcgact ctacgatttt      240

aactcctact ggcgagtcca cgccggtaac ttctctacca tccctcagta ctttaaggag      300

aacggatacg tgactatgtc cgtgggcaag gttttccacc ccggtatttc ctctaaccat      360

accgacgatt ctccttactc ctggtctttt cccccttacc acccctcgtc cgagaagtac      420

gagaacacca agacttgccg aggccctgac ggagagctgc atgctaacct gctctgtccc      480

gtcgacgtgc tggatgttcc tgagggaacc ctccccgata agcagtccac tgagcaggcc      540

attcagctgc tcgagaagat gaagacctcg gcctccccct tctttctggc tgtcggctac      600

cacaagcccc atatcccttt ccgataccct aaggagtttc agaagctgta ccccctcgag      660

aacattaccc tggctcccga ccctgaggtt cctgatggtc tgcctcccgt ggcttacaac      720

ccttggatgg acatccgaca gcgagaggat gtgcaggccc tgaacatctc cgttccctac      780

ggtcccattc ctgtcgactt ccagcgaaag attcgacagt cttactttgc ttctgtgtcg      840

tacctggaca cccaggttgg tcgactgctc tccgccctcg acgatctgca gctcgccaac      900

tcgaccatca ttgctttcac ttccgaccac ggatgggccc tgggagagca tggcgagtgg      960

gctaagtact ctaacttcga cgttgccacc cacgtccctc tgatctttta cgttcctgga     1020

cgaactgcct ccctccctga ggctggtgaa aagctgttcc cttacctcga cccctttgat     1080

tccgcttctc agctgatgga gcctggccga cagtctatgg acctggtcga gctcgtgtcg     1140

ctgttcccca ccctggctgg tctggctggc ctgcaggtcc ctccccgatg ccccgtgcct     1200

tctttccacg ttgagctctg tcgagaggga aagaacctgc tcaagcattt ccgatttcga     1260

gacctggagg aagaccccta cctccctggc aacccccgag agctgatcgc ctactcccag     1320

tacccccgac cttctgacat tcctcagtgg aactctgaca agccctcgct caaggatatc     1380

aagattatgg gctactccat ccgaaccatt gactaccgat acactgtttg ggtcggtttc     1440

aaccccgacg agttcctggc caacttttcg gatattcacg ctggagagct gtacttcgtc     1500

gactctgatc ccctccagga ccataacatg tacaacgact cgcagggcgg tgacctcttc     1560

cagctcctga tgcct                                                      1575


<210>  21
<211>  487
<212>  PRT
<213>  human PDI mature sequence

<400>  21

Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser Asn 
1               5                   10                  15      


Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe Tyr 
            20                  25                  30          


Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala Lys 
        35                  40                  45              


Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala Lys 
    50                  55                  60                  


Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val Arg 
65                  70                  75                  80  


Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser Pro 
                85                  90                  95      


Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp Leu 
            100                 105                 110         


Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala Ala 
        115                 120                 125             


Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe Phe 
    130                 135                 140                 


Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala Glu 
145                 150                 155                 160 


Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val Phe 
                165                 170                 175     


Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys Phe 
            180                 185                 190         


Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn Leu 
        195                 200                 205             


Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe Thr 
    210                 215                 220                 


Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His Ile 
225                 230                 235                 240 


Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu Ser 
                245                 250                 255     


Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe Ile 
            260                 265                 270         


Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe Phe 
        275                 280                 285             


Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu Glu 
    290                 295                 300                 


Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala Glu 
305                 310                 315                 320 


Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys Pro 
                325                 330                 335     


His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro Val 
            340                 345                 350         


Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu Lys 
        355                 360                 365             


Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys 
    370                 375                 380                 


Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp His 
385                 390                 395                 400 


Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val Glu 
                405                 410                 415     


Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala Ser 
            420                 425                 430         


Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp Gly 
        435                 440                 445             


Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp Asp 
    450                 455                 460                 


Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu Glu 
465                 470                 475                 480 


Asp Asp Asp Gln Lys Ala Val 
                485         


<210>  22
<211>  1461
<212>  DNA
<213>  human PDI protein coding sequence

<400>  22
gacgcccccg aggaagagga ccacgtcctg gtcctgcgaa agtctaactt cgccgaggcc       60

ctggccgccc acaagtacct gctggtcgaa ttctacgccc cctggtgcgg ccactgcaag      120

gccctcgctc ccgagtacgc caaggccgct ggcaagctga aggccgaggg ctctgagatc      180

cgactggcca aggtggacgc caccgaggaa tctgacctgg cccagcagta cggcgtgcga      240

ggctacccca ccatcaagtt cttccgaaac ggcgacaccg cctctcccaa ggagtacacc      300

gccggacgag aggccgacga catcgtgaac tggctgaaga agcgaaccgg acccgccgct      360

actactctgc ccgacggcgc tgccgccgag tctctggtcg agtcctctga ggtggccgtg      420

atcggcttct tcaaggacgt cgagtctgac tctgccaagc agttcctgca ggccgccgag      480

gccatcgacg acattccctt cggcatcacc tctaactctg acgtgttctc taagtaccag      540

ctggacaagg acggcgtggt gctgttcaag aagttcgacg agggccgaaa caacttcgag      600

ggcgaggtga ccaaggaaaa cctgctggac ttcatcaagc acaaccagct gcccctggtg      660

atcgagttca ccgagcagac cgcccccaag attttcggcg gcgagatcaa gacccacatc      720

ctgctgtttc tgcccaagtc tgtgtctgac tacgacggca agctgtctaa cttcaagacc      780

gccgctgagt ctttcaaggg caagatcctg ttcatcttca tcgactctga ccacaccgac      840

aaccagcgaa tcctcgagtt cttcggcctg aagaaagaag aatgtcccgc cgtccgactg      900

atcaccctcg aggaagagat gaccaagtac aagcccgagt ctgaggaact gaccgccgag      960

cgaatcaccg agttctgcca ccgattcctc gagggcaaga tcaagcccca cctgatgtct     1020

caggaactgc ccgaggactg ggataagcag cccgtgaagg tgctggtggg caagaacttc     1080

gaggacgtgg ccttcgacga gaagaagaac gttttcgtcg agttttacgc tccttggtgt     1140

ggacactgta agcagctggc ccccatctgg gacaagctgg gcgagactta caaggaccac     1200

gagaacatcg tgatcgccaa gatggactct accgccaacg aggtcgaggc cgtgaaggtc     1260

cactcgttcc ccaccctgaa gttctttccc gcctctgccg accgaaccgt gatcgactac     1320

aacggcgagc gaaccctgga cggcttcaag aagtttctcg agtctggcgg ccaggacggc     1380

gctggcgacg acgacgacct cgaggatctc gaagaagccg aggaacccga catggaagaa     1440

gacgacgacc agaaggccgt c                                               1461


<210>  23
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hFGE leader sequence

<400>  23

Met Ala Ala Pro Ala Leu Gly Leu Val Cys Gly Arg Cys Pro Glu Leu 
1               5                   10                  15      


Gly Leu Val Leu Leu Leu Leu Leu Leu Ser Leu Leu Cys Gly Ala Ala 
            20                  25                  30          


Gly 
    


<210>  24
<211>  480
<212>  PRT
<213>  Homo sapiens sulfamidase protein mature sequence

<400>  24

Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu 
1               5                   10                  15      


Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala 
            20                  25                  30          


Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser 
        35                  40                  45              


Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His 
    50                  55                  60                  


Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser 
65                  70                  75                  80  


Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val 
                85                  90                  95      


Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr 
            100                 105                 110         


Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val 
        115                 120                 125             


Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln 
    130                 135                 140                 


Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro 
145                 150                 155                 160 


His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys 
                165                 170                 175     


Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro 
            180                 185                 190         


Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn 
        195                 200                 205             


Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly 
    210                 215                 220                 


Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala 
225                 230                 235                 240 


Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile 
                245                 250                 255     


Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu 
            260                 265                 270         


Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val 
        275                 280                 285             


Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp 
    290                 295                 300                 


Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr 
305                 310                 315                 320 


Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro 
                325                 330                 335     


Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val Thr Met 
            340                 345                 350         


Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu Val His 
        355                 360                 365             


Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val 
    370                 375                 380                 


Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro 
385                 390                 395                 400 


Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp 
                405                 410                 415     


Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala 
            420                 425                 430         


Thr Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu 
        435                 440                 445             


Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp 
    450                 455                 460                 


Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn 
465                 470                 475                 480 


<210>  25
<211>  1440
<212>  DNA
<213>  coding sequence of mature sulfamidase (SGSH)

<400>  25
cgaccccgaa acgccctcct cctcctcgct gatgatggcg gtttcgagtc gggtgcctac       60

aacaactccg ctatcgctac ccctcacctc gacgctctgg ctcgacgatc tctgctcttc      120

cgaaacgcct ttacctccgt gtcctcttgc tctccctcgc gagcttctct gctcactgga      180

ctccctcagc accagaacgg aatgtacggc ctgcatcagg acgttcacca tttcaactct      240

tttgataagg tccgatcgct ccctctgctc ctgtcccagg ctggtgttcg aaccggtatc      300

attggaaaga agcacgtcgg acccgagacc gtgtaccctt tcgactttgc ttacactgag      360

gagaacggct ccgttctgca ggtcggccga aacatcaccc gaattaagct cctggtccga      420

aagttcctcc agactcagga cgatcgaccc ttctttctgt acgtggcctt tcacgaccct      480

caccgatgcg gacactctca gcctcagtac ggtaccttct gtgagaagtt tggaaacggc      540

gagtccggta tgggacgaat ccccgactgg acccctcagg cttacgaccc cctcgatgtc      600

ctggtgcctt acttcgttcc caacacccct gctgctcgag ctgacctcgc tgctcagtac      660

accactgtcg gccgaatgga tcagggcgtg ggtctcgttc tgcaggagct gcgagacgct      720

ggtgtgctca acgataccct ggttatcttc acttctgaca acggtattcc ctttccttcg      780

ggacgaacca acctgtactg gcccggaact gctgagcctc tcctggtctc gtcccctgag      840

caccctaagc gatggggaca ggtttcggag gcttacgtct ccctcctgga cctcaccccc      900

actatcctgg attggttctc tattccctac ccttcgtacg ccatctttgg atctaagacc      960

attcatctga ctggacgatc cctcctgcct gctctcgagg ctgagcctct gtgggctacc     1020

gtgttcggct cccagtctca ccatgaggtt actatgtcct accccatgcg atctgtccag     1080

caccgacatt tccgactcgt gcacaacctg aacttcaaga tgccctttcc tatcgaccag     1140

gatttctacg tctctcccac ctttcaggac ctcctgaacc gaaccactgc cggccagcct     1200

accggttggt acaaggatct ccgacactac tactaccgag ctcgatggga gctgtacgac     1260

cgatcccgag atccccatga gacccagaac ctggccactg accctcgatt cgctcagctc     1320

ctggagatgc tccgagacca gctggccaag tggcagtggg agacccacga tccctgggtg     1380

tgtgcccccg acggtgtgct cgaggagaag ctgtcccccc agtgtcagcc cctgcataac     1440


<210>  26
<211>  163
<212>  PRT
<213>  MNS1 anchorage domain (AA 1-163 of XP_502939.1)

<400>  26

Met Ser Phe Asn Ile Pro Lys Thr Thr Pro Asn Phe Ser Ala Lys Ala 
1               5                   10                  15      


Arg Lys Leu Glu Asp Gln Leu Trp Gln Ala Ser Gly Leu Glu Lys Ser 
            20                  25                  30          


Lys Asp Ser Thr Leu Pro Leu Tyr Lys Asp Lys Pro Tyr Gly Glu Gly 
        35                  40                  45              


Phe Val Ala Arg Thr Thr Ser Gly Arg Arg Arg Arg Asn Ile Ile Tyr 
    50                  55                  60                  


Gly Val Val Val Gly Leu Leu Phe Trp Ala Ile Tyr Thr Phe Ser Arg 
65                  70                  75                  80  


Ser Leu Asp Gly Asn Val Ser Leu Lys Asp Gly Ile Lys Asp Tyr Glu 
                85                  90                  95      


Phe Lys Gly Trp Lys Gly Arg Gly Lys Pro Lys Thr Asn Trp Val Ala 
            100                 105                 110         


Glu Gln Asn Ala Val Lys Gln Ala Phe Val Asp Ser Trp Asn Gly Tyr 
        115                 120                 125             


His Lys Tyr Ala Trp Gly Lys Asp Val Tyr Lys Pro Gln Thr Lys Thr 
    130                 135                 140                 


Gly Lys Asn Met Gly Pro Lys Pro Leu Gly Trp Phe Ile Val Asp Ser 
145                 150                 155                 160 


Leu Asp Ser 
            


<210>  27
<211>  489
<212>  DNA
<213>  Coding sequence for the MNS1 anchorage domain (AA 1-163 of XP_502939.1)

<400>  27
atgtcgttca acattcccaa gaccaccccc aacttctcgg ctaaggctcg aaagctggag       60

gatcagctct ggcaggcttc tggactcgag aagtccaagg actctaccct gcctctctac      120

aaggataagc cctacggaga gggcttcgtg gctcgaacca cttccggccg acgacgacga      180

aacatcatct acggcgtcgt ggttggtctg ctcttctggg ccatctacac cttttctcga      240

tcgctggacg gtaacgtctc tctcaaggac ggaattaagg attacgagtt caagggctgg      300

aagggtcgag gaaagcccaa gactaactgg gtggccgagc agaacgctgt taagcaggcc      360

tttgtcgact cctggaacgg ctaccataag tacgcctggg gcaaggatgt gtacaagccc      420

cagaccaaga ctggaaagaa catgggcccc aagcctctgg gatggttcat cgtggactct      480

ctggattcc                                                              489


<210>  28
<211>  118
<212>  PRT
<213>  WBP1 anchorage domain (AA 400-505 of XP_502492.1)

<400>  28

Asp His Leu Pro Thr Thr Gly Phe Thr Met Leu Asn Pro Tyr Tyr Arg 
1               5                   10                  15      


Leu Thr Leu Glu Gln Thr Gly Thr Thr Asn Phe Ser Ala Ile Tyr Ser 
            20                  25                  30          


Thr Thr Phe Lys Ile Pro Asp Gln His Gly Val Phe Thr Phe Asn Leu 
        35                  40                  45              


Asp Tyr Lys Arg Pro Gly Tyr Thr Phe Ile Glu Glu Lys Thr Arg Ala 
    50                  55                  60                  


Thr Ile Arg His Thr Ala Asn Asp Glu Trp Pro Arg Ser Trp Glu Ile 
65                  70                  75                  80  


Thr Asn Ser Trp Val Tyr Leu Thr Ser Ala Val Met Val Val Ile Ala 
                85                  90                  95      


Trp Phe Leu Phe Val Val Phe Tyr Leu Phe Val Gly Lys Ala Asp Lys 
            100                 105                 110         


Glu Ala Val His Lys Gln 
        115             


<210>  29
<211>  354
<212>  DNA
<213>  Coding sequence for the WBP1 anchorage domain (AA 400-505 of XP_502492.1)

<400>  29
gatcacctcc ccaccactgg cttcaccatg ctgaacccct actaccgact gaccctcgag       60

cagactggca ccactaactt ctccgccatc tactctacca cttttaagat tcctgaccag      120

catggcgtgt tcacctttaa cctcgattac aagcgacccg gttacacctt catcgaggag      180

aagacccgag ccactattcg acacaccgct aacgacgagt ggccccgatc ctgggagatc      240

accaactctt gggtctacct gacttcggcc gtgatggtcg tgattgcttg gttcctcttc      300

gtggtgttct acctgtttgt gggaaaggct gataaggaag ctgttcataa gcag            354


<210>  30
<211>  373
<212>  PRT
<213>  ERp44 mature protein

<400>  30

Glu Ile Thr Ser Leu Asp Thr Glu Asn Ile Asp Glu Ile Leu Asn Asn 
1               5                   10                  15      


Ala Asp Val Ala Leu Val Asn Phe Tyr Ala Asp Trp Cys Arg Phe Ser 
            20                  25                  30          


Gln Met Leu His Pro Ile Phe Glu Glu Ala Ser Asp Val Ile Lys Glu 
        35                  40                  45              


Glu Phe Pro Asn Glu Asn Gln Val Val Phe Ala Arg Val Asp Cys Asp 
    50                  55                  60                  


Gln His Ser Asp Ile Ala Gln Arg Tyr Arg Ile Ser Lys Tyr Pro Thr 
65                  70                  75                  80  


Leu Lys Leu Phe Arg Asn Gly Met Met Met Lys Arg Glu Tyr Arg Gly 
                85                  90                  95      


Gln Arg Ser Val Lys Ala Leu Ala Asp Tyr Ile Arg Gln Gln Lys Ser 
            100                 105                 110         


Asp Pro Ile Gln Glu Ile Arg Asp Leu Ala Glu Ile Thr Thr Leu Asp 
        115                 120                 125             


Arg Ser Lys Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys Asp Ser Asp 
    130                 135                 140                 


Asn Tyr Arg Val Phe Glu Arg Val Ala Asn Ile Leu His Asp Asp Cys 
145                 150                 155                 160 


Ala Phe Leu Ser Ala Phe Gly Asp Val Ser Lys Pro Glu Arg Tyr Ser 
                165                 170                 175     


Gly Asp Asn Ile Ile Tyr Lys Pro Pro Gly His Ser Ala Pro Asp Met 
            180                 185                 190         


Val Tyr Leu Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp Ile 
        195                 200                 205             


Gln Asp Lys Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn Gly 
    210                 215                 220                 


Glu Glu Leu Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His Met 
225                 230                 235                 240 


Lys Glu Asp Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala Arg 
                245                 250                 255     


Gln Leu Ile Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp Cys 
            260                 265                 270         


Asp Lys Phe Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala Asp 
        275                 280                 285             


Cys Pro Val Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe Gly 
    290                 295                 300                 


Asp Phe Lys Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val Phe 
305                 310                 315                 320 


Asp Leu His Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro Asp 
                325                 330                 335     


Pro Thr Asp Thr Ala Pro Gly Glu Gln Ala Gln Asp Val Ala Ser Ser 
            340                 345                 350         


Pro Pro Glu Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg Tyr 
        355                 360                 365             


Thr Leu Leu Arg Asp 
    370             


<210>  31
<211>  1119
<212>  DNA
<213>  Coding sequence for the ERp44 mature protein

<400>  31
gagattactt ccctggatac tgagaacatc gacgagattc tgaacaacgc cgacgtggcc       60

ctggtcaact tctacgccga ctggtgccga ttttcccaga tgctccaccc catcttcgag      120

gaggcttctg atgtgattaa ggaggagttc cctaacgaga accaggtcgt gtttgcccga      180

gttgactgtg atcagcattc tgacatcgct cagcgatacc gaatttcgaa gtaccccacc      240

ctgaagctct tccgaaacgg aatgatgatg aagcgagagt accgaggcca gcgatcggtt      300

aaggccctgg ctgactacat ccgacagcag aagtccgacc ccatccagga gattcgagat      360

ctggccgaga ttaccactct cgaccgatct aagcgaaaca tcattggtta cttcgagcag      420

aaggactcgg ataactaccg agtgtttgag cgagttgcta acatcctgca cgacgattgc      480

gccttcctct ctgcttttgg agacgtctcg aagcccgagc gatactccgg cgacaacatc      540

atctacaagc cccctggaca ttctgcccct gacatggttt acctgggcgc tatgaccaac      600

ttcgacgtca cttacaactg gattcaggat aagtgtgttc ccctcgtccg agagattacc      660

tttgagaacg gcgaggagct gactgaggag ggtctccctt tcctgatcct ctttcacatg      720

aaggaggata ccgagtccct ggagattttc cagaacgagg tggcccgaca gctgatctcc      780

gagaagggaa ctattaactt cctccacgct gactgcgata agtttcgaca ccccctgctc      840

catatccaga agacccccgc cgactgtcct gtcatcgcta ttgattcttt ccgacacatg      900

tacgtcttcg gcgactttaa ggatgtgctg attcccggca agctgaagca gttcgtgttt      960

gacctgcact ccggaaagct ccatcgagag ttccaccatg gccccgaccc taccgatact     1020

gcccctggag agcaggccca ggacgttgct tcctctcccc ctgagtcgtc cttccagaag     1080

ctggccccct ccgagtaccg atacaccctc ctgcgagac                            1119


<210>  32
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion construct: LIP2-BtFGE-6xHis-HDEL

<400>  32

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Ala Gly Gly Glu Glu Ala Gly Pro Glu Ala Gly Ala Pro Ser Leu 
            20                  25                  30          


Val Gly Ser Cys Gly Cys Gly Asn Pro Gln Arg Pro Gly Ala Gln Gly 
        35                  40                  45              


Ser Ser Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly 
    50                  55                  60                  


Ser Val Pro Gly Gly Arg Pro Ser Pro Pro Thr Lys Met Val Pro Ile 
65                  70                  75                  80  


Pro Ala Gly Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln 
                85                  90                  95      


Asp Gly Glu Ala Pro Ala Arg Arg Val Ala Ile Asp Ala Phe Tyr Met 
            100                 105                 110         


Asp Ala Tyr Glu Val Ser Asn Ala Glu Phe Glu Lys Phe Val Asn Ser 
        115                 120                 125             


Thr Gly Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe 
    130                 135                 140                 


Glu Gly Met Leu Ser Glu Gln Val Lys Ser Asp Ile Gln Gln Ala Val 
145                 150                 155                 160 


Ala Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His 
                165                 170                 175     


Pro Glu Gly Pro Asp Ser Thr Val Leu His Arg Pro Asp His Pro Val 
            180                 185                 190         


Leu His Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly 
        195                 200                 205             


Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly 
    210                 215                 220                 


Leu Gln Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly 
225                 230                 235                 240 


Gln His Tyr Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr 
                245                 250                 255     


Gly Glu Asp Gly Phe Arg Gly Thr Ala Pro Val Asp Ala Phe Pro Pro 
            260                 265                 270         


Asn Gly Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr 
        275                 280                 285             


Ser Asp Trp Trp Thr Val His His Ser Ala Glu Glu Thr Ile Asn Pro 
    290                 295                 300                 


Lys Gly Pro Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Met Cys His Lys Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser 
                325                 330                 335     


Gln Asn Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala 
            340                 345                 350         


Ala Asp His Leu Pro Thr Thr Gly Ala Asp His Leu Pro Thr Thr Gly 
        355                 360                 365             


His His His His His His His Asp Glu Leu 
    370                 375             


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RDEL tag

<400>  33

Arg Asp Glu Leu 
1               


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved sequence of Iduronate Sulfatase

<400>  34

Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg 
1               5                   10          


<210>  35
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MNS1-HpFGE- 6xHis fusion construct

<400>  35

Met Ser Phe Asn Ile Pro Lys Thr Thr Pro Asn Phe Ser Ala Lys Ala 
1               5                   10                  15      


Arg Lys Leu Glu Asp Gln Leu Trp Gln Ala Ser Gly Leu Glu Lys Ser 
            20                  25                  30          


Lys Asp Ser Thr Leu Pro Leu Tyr Lys Asp Lys Pro Tyr Gly Glu Gly 
        35                  40                  45              


Phe Val Ala Arg Thr Thr Ser Gly Arg Arg Arg Arg Asn Ile Ile Tyr 
    50                  55                  60                  


Gly Val Val Val Gly Leu Leu Phe Trp Ala Ile Tyr Thr Phe Ser Arg 
65                  70                  75                  80  


Ser Leu Asp Gly Asn Val Ser Leu Lys Asp Gly Ile Lys Asp Tyr Glu 
                85                  90                  95      


Phe Lys Gly Trp Lys Gly Arg Gly Lys Pro Lys Thr Asn Trp Val Ala 
            100                 105                 110         


Glu Gln Asn Ala Val Lys Gln Ala Phe Val Asp Ser Trp Asn Gly Tyr 
        115                 120                 125             


His Lys Tyr Ala Trp Gly Lys Asp Val Tyr Lys Pro Gln Thr Lys Thr 
    130                 135                 140                 


Gly Lys Asn Met Gly Pro Lys Pro Leu Gly Trp Phe Ile Val Asp Ser 
145                 150                 155                 160 


Leu Asp Ser Met Gly Thr Asp Lys Ala Lys Ile Tyr Leu Asp Gly Glu 
                165                 170                 175     


Ser Pro Ser Arg Leu Val Thr Leu Asp Pro Tyr Tyr Phe Asp Val Tyr 
            180                 185                 190         


Glu Val Ser Asn Ser Glu Phe Glu Leu Phe Val Asn Thr Thr Ser Tyr 
        195                 200                 205             


Ile Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Leu Glu Ala Arg 
    210                 215                 220                 


Ile Ser Glu Glu Val Lys Lys Asp Ile Ser Gln Val Val Ala Ala Ala 
225                 230                 235                 240 


Pro Trp Trp Leu Pro Val Lys Gly Ala Glu Trp Arg His Pro Glu Gly 
                245                 250                 255     


Pro Asp Ser Ser Ile Ser Ser Arg Met Asp His Pro Val Thr His Ile 
            260                 265                 270         


Ser Trp Asn Asp Ala Thr Ala Tyr Cys Gln Trp Ala Gly Lys Arg Leu 
        275                 280                 285             


Pro Thr Glu Ala Glu Trp Glu Asn Ala Ala Arg Gly Gly Leu Asn Asn 
    290                 295                 300                 


Arg Leu Phe Pro Trp Gly Asn Lys Leu Met Pro Lys Asp His His Arg 
305                 310                 315                 320 


Val Asn Ile Trp Gln Gly Glu Phe Pro Lys Val Asn Thr Ala Glu Asp 
                325                 330                 335     


Gly Tyr Glu Gly Thr Cys Pro Val Thr Ala Phe Glu Pro Asn Gly Tyr 
            340                 345                 350         


Gly Leu Tyr Asn Thr Val Gly Asn Ala Trp Glu Trp Val Ala Asp Trp 
        355                 360                 365             


Trp Thr Thr Val His Ser Pro Glu Ser Gln Asn Asn Pro Val Gly Pro 
    370                 375                 380                 


Asp Glu Gly Thr Asp Lys Val Lys Lys Gly Gly Ser Tyr Met Cys His 
385                 390                 395                 400 


Ile Ser Tyr Cys Tyr Arg Tyr Arg Cys Glu Ala Arg Ser Gln Asn Ser 
                405                 410                 415     


Pro Asp Ser Ser Ala Cys Asn Leu Gly Phe Arg Cys Ala Ala Thr Asn 
            420                 425                 430         


Leu Pro Glu Asp Ile Pro Cys Ser Asn Cys Asn Asp Ser Thr Pro His 
        435                 440                 445             


His His His His His 
    450             


<210>  36
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for MNS1-HpFGE- 6xHis fusion construct

<400>  36
atgtcgttca acattcccaa gactacccct aacttctcgg ctaaggctcg aaagctggag       60

gatcagctct ggcaggcttc tggactggag aagtccaagg actctaccct gcccctctac      120

aaggataagc cttacggaga gggattcgtg gctcgaacca cctccggccg acgacgacga      180

aacatcatct acggcgtcgt ggttggtctg ctcttctggg ctatctacac cttttcccga      240

tctctggacg gcaacgtctc cctcaaggac ggtattaagg attacgagtt caagggatgg      300

aagggccgag gcaagcccaa gaccaactgg gtggctgagc agaacgccgt gaagcaggct      360

tttgttgact cttggaacgg ataccacaag tacgcctggg gcaaggatgt ctacaagccc      420

cagaccaaga ctggaaagaa catgggcccc aagcctctgg gctggttcat cgtggactcg      480

ctcgattcca tgggcaccga caaggccaag atctacctgg atggtgagtc gccctcccga      540

ctggttactc tcgaccctta ctactttgat gtttacgagg tctctaactc ggagttcgag      600

ctgtttgtca acaccacttc ttacatcacc gaggccgaga agttcggtga ctcctttgtc      660

ctcgaggctc gaatctctga ggaagtcaag aaggatattt ctcaggtggt ggccgctgcc      720

ccctggtggc tccctgttaa gggtgctgag tggcgacacc ctgagggacc tgactcctct      780

atctcgtccc gaatggatca ccccgttacc catatttcct ggaacgacgc tactgcctac      840

tgtcagtggg ctggcaagcg actgcctacc gaggctgagt gggagaacgc tgctcgaggc      900

ggtctgaaca accgactctt cccctgggga aacaagctca tgcctaagga ccaccatcga      960

gtgaacatct ggcagggcga gttccccaag gttaacaccg ccgaggacgg ttacgaggga     1020

acctgccccg tgactgcttt tgagcctaac ggatacggcc tgtacaacac tgtcggaaac     1080

gcctgggagt gggtggctga ctggtggacc actgttcact ctcccgagtc gcagaacaac     1140

cccgttggtc ctgacgaggg aaccgataag gtcaagaagg gaggctcgta catgtgccat     1200

atttcttact gttaccgata ccgatgcgag gcccgatccc agaactctcc cgactcttcg     1260

gcttgtaacc tgggtttccg atgcgctgcc accaacctcc ctgaggacat tccctgctct     1320

aactgtaacg actccactcc ccaccaccat caccatcact aa                        1362


<210>  37
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MNS1-BtFGE-6xHis fusion construct

<400>  37

Met Ser Phe Asn Ile Pro Lys Thr Thr Pro Asn Phe Ser Ala Lys Ala 
1               5                   10                  15      


Arg Lys Leu Glu Asp Gln Leu Trp Gln Ala Ser Gly Leu Glu Lys Ser 
            20                  25                  30          


Lys Asp Ser Thr Leu Pro Leu Tyr Lys Asp Lys Pro Tyr Gly Glu Gly 
        35                  40                  45              


Phe Val Ala Arg Thr Thr Ser Gly Arg Arg Arg Arg Asn Ile Ile Tyr 
    50                  55                  60                  


Gly Val Val Val Gly Leu Leu Phe Trp Ala Ile Tyr Thr Phe Ser Arg 
65                  70                  75                  80  


Ser Leu Asp Gly Asn Val Ser Leu Lys Asp Gly Ile Lys Asp Tyr Glu 
                85                  90                  95      


Phe Lys Gly Trp Lys Gly Arg Gly Lys Pro Lys Thr Asn Trp Val Ala 
            100                 105                 110         


Glu Gln Asn Ala Val Lys Gln Ala Phe Val Asp Ser Trp Asn Gly Tyr 
        115                 120                 125             


His Lys Tyr Ala Trp Gly Lys Asp Val Tyr Lys Pro Gln Thr Lys Thr 
    130                 135                 140                 


Gly Lys Asn Met Gly Pro Lys Pro Leu Gly Trp Phe Ile Val Asp Ser 
145                 150                 155                 160 


Leu Asp Ser Gly Gly Glu Glu Ala Gly Pro Glu Ala Gly Ala Pro Ser 
                165                 170                 175     


Leu Val Gly Ser Cys Gly Cys Gly Asn Pro Gln Arg Pro Gly Ala Gln 
            180                 185                 190         


Gly Ser Ser Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro 
        195                 200                 205             


Gly Ser Val Pro Gly Gly Arg Pro Ser Pro Pro Thr Lys Met Val Pro 
    210                 215                 220                 


Ile Pro Ala Gly Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys 
225                 230                 235                 240 


Gln Asp Gly Glu Ala Pro Ala Arg Arg Val Ala Ile Asp Ala Phe Tyr 
                245                 250                 255     


Met Asp Ala Tyr Glu Val Ser Asn Ala Glu Phe Glu Lys Phe Val Asn 
            260                 265                 270         


Ser Thr Gly Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val 
        275                 280                 285             


Phe Glu Gly Met Leu Ser Glu Gln Val Lys Ser Asp Ile Gln Gln Ala 
    290                 295                 300                 


Val Ala Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg 
305                 310                 315                 320 


His Pro Glu Gly Pro Asp Ser Thr Val Leu His Arg Pro Asp His Pro 
                325                 330                 335     


Val Leu His Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala 
            340                 345                 350         


Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly 
        355                 360                 365             


Gly Leu Gln Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys 
    370                 375                 380                 


Gly Gln His Tyr Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn 
385                 390                 395                 400 


Thr Gly Glu Asp Gly Phe Arg Gly Thr Ala Pro Val Asp Ala Phe Pro 
                405                 410                 415     


Pro Asn Gly Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp 
            420                 425                 430         


Thr Ser Asp Trp Trp Thr Val His His Ser Ala Glu Glu Thr Ile Asn 
        435                 440                 445             


Pro Lys Gly Pro Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser 
    450                 455                 460                 


Tyr Met Cys His Lys Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg 
465                 470                 475                 480 


Ser Gln Asn Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys 
                485                 490                 495     


Ala Ala Asp His Leu Pro Thr Thr Gly Ala Asp His Leu Pro Thr Thr 
            500                 505                 510         


Gly His His His His His His 
        515                 


<210>  38
<211>  1560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the MNS1-BtFGE-6xHis fusion construct

<400>  38
atgtcgttca acattcccaa gaccaccccc aacttctcgg ctaaggctcg aaagctggag       60

gatcagctct ggcaggcttc tggactcgag aagtccaagg actctaccct gcctctctac      120

aaggataagc cctacggaga gggcttcgtg gctcgaacca cttccggccg acgacgacga      180

aacatcatct acggcgtcgt ggttggtctg ctcttctggg ccatctacac cttttctcga      240

tcgctggacg gtaacgtctc tctcaaggac ggaattaagg attacgagtt caagggctgg      300

aagggtcgag gaaagcccaa gactaactgg gtggccgagc agaacgctgt taagcaggcc      360

tttgtcgact cctggaacgg ctaccataag tacgcctggg gcaaggatgt gtacaagccc      420

cagaccaaga ctggaaagaa catgggcccc aagcctctgg gatggttcat cgtggactct      480

ctggattccg gcggcgagga agccggtcct gaggctggag ctccttctct ggttggctcg      540

tgcggctgtg gaaaccccca gcgacctggt gctcagggct cctctgccgc tgcccaccga      600

tactctcgag aggccaacgc tcccggttct gtgcctggag gccgaccttc gccccctacc      660

aagatggtgc ccattcctgc tggagttttc accatgggca ctgacgatcc tcagatcaag      720

caggacggag aggctcctgc tcgacgagtt gccattgacg ctttttacat ggatgcttac      780

gaggtttcta acgccgagtt cgagaagttt gtcaactcga ccggatacct gactgaggcc      840

gagaagttcg gagactcctt cgtctttgag ggcatgctct ccgagcaggt caagtctgac      900

atccagcagg ctgtggctgc cgctccttgg tggctgcccg ttaagggtgc taactggcga      960

catcctgagg gtcctgactc caccgtcctg caccgacccg atcatcctgt cctccacgtg     1020

tcttggaacg acgccgtggc ttactgtacc tgggctggca agcgactgcc tactgaggct     1080

gagtgggagt actcttgccg aggtggactg cagaaccgac tcttcccttg gggtaacaag     1140

ctccagccca agggacagca ctacgccaac atttggcagg gcgagtttcc tgtcaccaac     1200

actggcgagg acggtttccg aggaaccgct cccgtggatg cctttccccc taacggatac     1260

ggcctgtaca acatcgtggg taacgcttgg gagtggacct ccgactggtg gactgttcac     1320

cattctgccg aggagaccat taaccctaag ggccctccct ctggcaagga ccgagtcaag     1380

aagggcggtt cgtacatgtg ccacaagtcc tactgttacc gataccgatg cgccgctcga     1440

tcgcagaaca cccctgactc ttctgcttcc aacctcggct tccgatgtgc cgctgatcac     1500

ctccccacca ctggcgctga ccacctgccc actactggac accaccacca ccaccattaa     1560


<210>  39
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lip2pre-6xHis-BtFGE-WBP1 fusion construct

<400>  39

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala His His His His His His Ala Gly Gly Glu Glu Ala Gly Pro Glu 
            20                  25                  30          


Ala Gly Ala Pro Ser Leu Val Gly Ser Cys Gly Cys Gly Asn Pro Gln 
        35                  40                  45              


Arg Pro Gly Ala Gln Gly Ser Ser Ala Ala Ala His Arg Tyr Ser Arg 
    50                  55                  60                  


Glu Ala Asn Ala Pro Gly Ser Val Pro Gly Gly Arg Pro Ser Pro Pro 
65                  70                  75                  80  


Thr Lys Met Val Pro Ile Pro Ala Gly Val Phe Thr Met Gly Thr Asp 
                85                  90                  95      


Asp Pro Gln Ile Lys Gln Asp Gly Glu Ala Pro Ala Arg Arg Val Ala 
            100                 105                 110         


Ile Asp Ala Phe Tyr Met Asp Ala Tyr Glu Val Ser Asn Ala Glu Phe 
        115                 120                 125             


Glu Lys Phe Val Asn Ser Thr Gly Tyr Leu Thr Glu Ala Glu Lys Phe 
    130                 135                 140                 


Gly Asp Ser Phe Val Phe Glu Gly Met Leu Ser Glu Gln Val Lys Ser 
145                 150                 155                 160 


Asp Ile Gln Gln Ala Val Ala Ala Ala Pro Trp Trp Leu Pro Val Lys 
                165                 170                 175     


Gly Ala Asn Trp Arg His Pro Glu Gly Pro Asp Ser Thr Val Leu His 
            180                 185                 190         


Arg Pro Asp His Pro Val Leu His Val Ser Trp Asn Asp Ala Val Ala 
        195                 200                 205             


Tyr Cys Thr Trp Ala Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu 
    210                 215                 220                 


Tyr Ser Cys Arg Gly Gly Leu Gln Asn Arg Leu Phe Pro Trp Gly Asn 
225                 230                 235                 240 


Lys Leu Gln Pro Lys Gly Gln His Tyr Ala Asn Ile Trp Gln Gly Glu 
                245                 250                 255     


Phe Pro Val Thr Asn Thr Gly Glu Asp Gly Phe Arg Gly Thr Ala Pro 
            260                 265                 270         


Val Asp Ala Phe Pro Pro Asn Gly Tyr Gly Leu Tyr Asn Ile Val Gly 
        275                 280                 285             


Asn Ala Trp Glu Trp Thr Ser Asp Trp Trp Thr Val His His Ser Ala 
    290                 295                 300                 


Glu Glu Thr Ile Asn Pro Lys Gly Pro Pro Ser Gly Lys Asp Arg Val 
305                 310                 315                 320 


Lys Lys Gly Gly Ser Tyr Met Cys His Lys Ser Tyr Cys Tyr Arg Tyr 
                325                 330                 335     


Arg Cys Ala Ala Arg Ser Gln Asn Thr Pro Asp Ser Ser Ala Ser Asn 
            340                 345                 350         


Leu Gly Phe Arg Cys Ala Ala Asp His Leu Pro Thr Thr Gly Ala Asp 
        355                 360                 365             


His Leu Pro Thr Thr Gly Phe Thr Met Leu Asn Pro Tyr Tyr Arg Leu 
    370                 375                 380                 


Thr Leu Glu Gln Thr Gly Thr Thr Asn Phe Ser Ala Ile Tyr Ser Thr 
385                 390                 395                 400 


Thr Phe Lys Ile Pro Asp Gln His Gly Val Phe Thr Phe Asn Leu Asp 
                405                 410                 415     


Tyr Lys Arg Pro Gly Tyr Thr Phe Ile Glu Glu Lys Thr Arg Ala Thr 
            420                 425                 430         


Ile Arg His Thr Ala Asn Asp Glu Trp Pro Arg Ser Trp Glu Ile Thr 
        435                 440                 445             


Asn Ser Trp Val Tyr Leu Thr Ser Ala Val Met Val Val Ile Ala Trp 
    450                 455                 460                 


Phe Leu Phe Val Val Phe Tyr Leu Phe Val Gly Lys Ala Asp Lys Glu 
465                 470                 475                 480 


Ala Val His Lys Gln 
                485 


<210>  40
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the Lip2pre-6xHis-BtFGE-WBP1 fusion construct

<400>  40
atgaagctgt ctaccattct gtttactgct tgtgctaccc tggctgctgc ccaccaccat       60

caccatcacg ctggcggaga agaggctgga cccgaggctg gagctccttc cctggtggga      120

tcgtgtggat gtggaaaccc tcagcgacct ggagctcagg gttcttctgc cgctgcccat      180

cgatactccc gagaggctaa cgctcctggt tctgtgcctg gcggacgacc ttctcctccc      240

accaagatgg tccccatccc tgccggagtt ttcaccatgg gtactgacga tcctcagatc      300

aagcaggacg gagaggctcc tgctcgacga gttgccattg acgcttttta catggatgcc      360

tacgaggtct ctaacgctga gttcgagaag tttgttaact ccaccggata cctcactgag      420

gccgagaagt tcggcgactc cttcgtcttt gagggaatgc tgtcggagca ggttaagtct      480

gatattcagc aggctgtggc tgccgctcct tggtggctgc ccgtcaaggg agctaactgg      540

cgacatcccg agggtcctga ctcgaccgtt ctgcaccgac ccgatcatcc tgttctccac      600

gtgtcttgga acgacgctgt ggcttactgc acctgggctg gaaagcgact ccccactgag      660

gctgagtggg agtactcttg tcgaggtggc ctgcagaacc gactcttccc ttggggtaac      720

aagctgcagc ccaagggcca gcactacgcc aacatctggc agggagagtt tcctgttacc      780

aacactggag aggacggatt ccgaggtacc gctcctgtgg atgcttttcc ccctaacggt      840

tacggcctct acaacatcgt gggcaacgcc tgggagtgga cctcggactg gtggactgtc      900

caccattctg ctgaggagac cattaacccc aagggtcccc cttctggcaa ggatcgagtg      960

aagaagggag gttcctacat gtgtcacaag tcgtactgct accgataccg atgtgccgct     1020

cgatcccaga acacccctga ctcgtctgcc tcgaacctgg gattccgatg cgccgctgac     1080

catctgccta ccactggcgc tgatcacctc cccaccactg gcttcaccat gctgaacccc     1140

tactaccgac tgaccctcga gcagactggc accactaact tctctgccat ctactccacc     1200

acttttaaga ttcctgacca gcatggtgtc ttcaccttta acctcgatta caagcgaccc     1260

ggctacactt tcatcgagga gaagacccga gccactattc gacacaccgc taacgacgag     1320

tggccccgat cttgggagat caccaactcc tgggtgtacc tgacttcggc cgtcatggtg     1380

gtcattgctt ggttcctgtt cgtcgtgttt tacctgttcg ttggcaaggc tgacaaggaa     1440

gctgttcata agcagtaa                                                   1458


<210>  41
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Lip2pre-BtFGE-HpFGE-6xHis-HDEL fusion construct

<400>  41

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Ala Gly Gly Glu Glu Ala Gly Pro Glu Ala Gly Ala Pro Ser Leu 
            20                  25                  30          


Val Gly Ser Cys Gly Cys Gly Asn Pro Gln Arg Pro Gly Ala Gln Gly 
        35                  40                  45              


Ser Ser Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly 
    50                  55                  60                  


Ser Val Pro Gly Gly Arg Pro Ser Pro Pro Thr Lys Met Val Pro Ile 
65                  70                  75                  80  


Pro Ala Gly Val Phe Thr Met Gly Thr Asp Lys Ala Lys Ile Tyr Leu 
                85                  90                  95      


Asp Gly Glu Ser Pro Ser Arg Leu Val Thr Leu Asp Pro Tyr Tyr Phe 
            100                 105                 110         


Asp Val Tyr Glu Val Ser Asn Ser Glu Phe Glu Leu Phe Val Asn Thr 
        115                 120                 125             


Thr Ser Tyr Ile Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Leu 
    130                 135                 140                 


Glu Ala Arg Ile Ser Glu Glu Val Lys Lys Asp Ile Ser Gln Val Val 
145                 150                 155                 160 


Ala Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Glu Trp Arg His 
                165                 170                 175     


Pro Glu Gly Pro Asp Ser Ser Ile Ser Ser Arg Met Asp His Pro Val 
            180                 185                 190         


Thr His Ile Ser Trp Asn Asp Ala Thr Ala Tyr Cys Gln Trp Ala Gly 
        195                 200                 205             


Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Asn Ala Ala Arg Gly Gly 
    210                 215                 220                 


Leu Asn Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Met Pro Lys Asp 
225                 230                 235                 240 


His His Arg Val Asn Ile Trp Gln Gly Glu Phe Pro Lys Val Asn Thr 
                245                 250                 255     


Ala Glu Asp Gly Tyr Glu Gly Thr Cys Pro Val Thr Ala Phe Glu Pro 
            260                 265                 270         


Asn Gly Tyr Gly Leu Tyr Asn Thr Val Gly Asn Ala Trp Glu Trp Val 
        275                 280                 285             


Ala Asp Trp Trp Thr Thr Val His Ser Pro Glu Ser Gln Asn Asn Pro 
    290                 295                 300                 


Val Gly Pro Asp Glu Gly Thr Asp Lys Val Lys Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Met Cys His Ile Ser Tyr Cys Tyr Arg Tyr Arg Cys Glu Ala Arg Ser 
                325                 330                 335     


Gln Asn Ser Pro Asp Ser Ser Ala Cys Asn Leu Gly Phe Arg Cys Ala 
            340                 345                 350         


Ala Thr Asn Leu Pro Glu Asp Ile Pro Cys Ser Asn Cys Asn Asp Ser 
        355                 360                 365             


Thr Pro His His His His His His His Asp Glu Leu 
    370                 375                 380 


<210>  42
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for Chimeric Lip2pre-BtFGE-HpFGE-6xHis-HDEL 
       fusion construct

<400>  42
atgaagctgt ctactattct gtttactgct tgcgctactc tggctgccgc tgccggaggc       60

gaggaagctg gtcccgaggc tggtgctccc tctctggtgg gttcgtgcgg ctgtggaaac      120

ccccagcgac ctggtgctca gggctcctct gccgctgccc accgatactc tcgagaggct      180

aacgctcctg gatcggtccc tggcggtcga ccctctcccc ctaccaagat ggtgcccatc      240

cctgccggtg ttttcaccat gggaactgac aaggctaaga tctacctgga tggcgagtcg      300

ccttcccgac tggtcaccct cgacccctac tactttgatg tttacgaggt ctctaactcg      360

gagttcgagc tgtttgtgaa caccacttct tacatcactg aggccgagaa gttcggtgac      420

tcctttgtcc tcgaggctcg aatctctgag gaagtcaaga aggatatttc tcaggtggtg      480

gctgccgctc cttggtggct ccccgttaag ggtgctgagt ggcgacaccc tgagggtcct      540

gactcgtcca tctcttcgcg aatggatcac cctgtcaccc atatttcctg gaacgacgcc      600

actgcttact gtcagtgggc tggcaagcga ctgcccaccg aggctgagtg ggagaacgct      660

gctcgaggcg gcctgaacaa ccgactcttc ccttggggaa acaagctcat gcccaaggac      720

caccatcgag tgaacatttg gcagggcgag ttccccaagg ttaacaccgc tgaggacgga      780

tacgagggta cctgccctgt gactgctttt gagcccaacg gatacggcct ctacaacact      840

gtcggaaacg cctgggagtg ggtggctgac tggtggacca ctgttcactc ccccgagtct      900

cagaacaacc ccgttggacc tgacgagggc accgataagg tcaagaaggg cggctcctac      960

atgtgccata tctcttactg ttaccgatac cgatgcgagg cccgatcgca gaactcccct     1020

gactcctctg cttgtaacct gggtttccga tgcgccgcta ccaacctccc cgaggatatt     1080

ccctgttcca actgtaacga ttccacccct caccaccatc accatcatca cgacgagctg     1140

taa                                                                   1143


<210>  43
<211>  338
<212>  PRT
<213>  Tupaia chinensis FGE

<400>  43

Glu Glu Ala Arg Thr Gly Ala Gly Ala Thr Ser Ala Gln Gly Pro Cys 
1               5                   10                  15      


Gly Cys Gly Thr Pro Gln Arg Pro Gly Ser His Gly Ser Ser Ala Ala 
            20                  25                  30          


Ala His Arg Tyr Ser Arg Glu Ala Asn Val Pro Gly Pro Val Pro Gly 
        35                  40                  45              


Glu Arg Gln Pro Glu Ala Thr Lys Met Val Pro Ile Pro Ala Gly Val 
    50                  55                  60                  


Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly Glu Ala 
65                  70                  75                  80  


Pro Ala Arg Arg Val Ala Ile Asp Ala Phe Tyr Met Asp Ala Tyr Glu 
                85                  90                  95      


Val Ser Asn Ala Glu Phe Glu Lys Phe Val Asn Ser Thr Gly Tyr Leu 
            100                 105                 110         


Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly Met Leu 
        115                 120                 125             


Ser Glu Gln Val Lys Thr Gly Ile Gln Gln Ala Val Ala Ala Ala Pro 
    130                 135                 140                 


Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu Gly Pro 
145                 150                 155                 160 


Asp Ser Thr Ile Leu His Arg Ala Asp His Pro Val Leu His Val Ser 
                165                 170                 175     


Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg Leu Pro 
            180                 185                 190         


Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu Gln Asn Arg 
        195                 200                 205             


Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Arg Gly Gln His Tyr Ala 
    210                 215                 220                 


Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Ala Glu Asp Gly 
225                 230                 235                 240 


Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly Tyr Gly 
                245                 250                 255     


Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp Trp Trp 
            260                 265                 270         


Thr Val Tyr His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly Pro Pro 
        275                 280                 285             


Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys His Lys 
    290                 295                 300                 


Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn Thr Pro 
305                 310                 315                 320 


Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp Arg Leu 
                325                 330                 335     


Pro Thr 
        


<210>  44
<211>  1014
<212>  DNA
<213>  Coding sequence for Tupaia chinensis FGE

<400>  44
gaggaagccc gaactggtgc tggtgctact tctgctcagg gaccctgcgg ttgcggtact       60

cctcagcgac ccggttctca cggctcgtct gccgctgccc accgatactc tcgagaggct      120

aacgttcctg gacctgtccc cggagagcga cagcctgagg ccaccaagat ggtccctatc      180

cccgctggcg tgttcaccat gggtactgac gatcctcaga tcaagcagga cggtgaagct      240

cctgctcgac gagttgccat tgacgctttt tacatggatg cctacgaggt gtccaacgct      300

gagttcgaga agtttgttaa ctctaccgga tacctgactg aggccgagaa gttcggagac      360

tccttcgtct ttgagggcat gctctctgag caggttaaga ccggcatcca gcaggctgtg      420

gctgccgctc cttggtggct gcctgtgaag ggagctaact ggcgacatcc tgagggtccc      480

gactccacta ttctgcaccg agctgatcat cctgtcctcc acgtgtcttg gaacgacgcc      540

gtcgcttact gtacctgggc tggcaagcga ctgcctactg aggctgagtg ggagtactcc      600

tgccgaggcg gtctgcagaa ccgactcttc ccttggggta acaagctcca gccccgagga      660

cagcactacg ccaacatctg gcagggagag tttcctgtca ccaacactgc tgaggacgga      720

ttccagggca ccgctcctgt ggatgctttt ccccctaacg gttacggact gtacaacatt      780

gttggaaacg cctgggagtg gacctcggac tggtggactg tgtaccattc cgttgaggag      840

accctcaacc ccaagggtcc cccttctgga aaggatcgag tgaagaaggg aggctcgtac      900

atgtgccaca agtcctactg ttaccgatac cgatgcgccg ctcgatctca gaacaccccc      960

gactcctctg cctcgaacct cggattccga tgtgctgctg accgactgcc cact           1014


<210>  45
<211>  341
<212>  PRT
<213>  Monodelphis domestica FGE

<400>  45

Ala Ala Arg Gly Leu Gly Ser Glu Ala Gly Ser Ala Ala Ala Asp Ala 
1               5                   10                  15      


Ala His Pro Ala Gly Thr Cys Gly Cys Gly Ser Pro Gln Arg Pro Gly 
            20                  25                  30          


Thr Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Val Ala Glu Pro Ala 
        35                  40                  45              


Ser Ala Glu Arg Pro Val Leu Thr Ser Gln Met Ala His Ile Pro Ala 
    50                  55                  60                  


Gly Val Phe Thr Met Gly Thr Asp Glu Pro Gln Ile Lys Gln Asp Gly 
65                  70                  75                  80  


Glu Gly Pro Ala Arg Arg Val Arg Ile Asn Ser Phe Tyr Met Asp Leu 
                85                  90                  95      


Tyr Glu Val Ser Asn Ala Glu Phe Glu Arg Phe Val Asn Ser Thr Gly 
            100                 105                 110         


Tyr Val Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Asp Ser 
        115                 120                 125             


Met Leu Ser Asp Gln Val Lys Ser Asp Ile His Gln Ala Val Ala Ala 
    130                 135                 140                 


Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu 
145                 150                 155                 160 


Gly Pro Asp Ser Ser Ile Leu His Arg Arg Asp His Pro Val Leu His 
                165                 170                 175     


Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg 
            180                 185                 190         


Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu Glu 
        195                 200                 205             


Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln His 
    210                 215                 220                 


Tyr Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Ser Asn Thr Gly Glu 
225                 230                 235                 240 


Asp Gly Tyr Gln Gly Thr Ala Pro Val Thr Ala Phe Pro Pro Asn Gly 
                245                 250                 255     


Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp 
            260                 265                 270         


Trp Trp Thr Val His His Ser Ala Asp Glu Thr Leu Asp Pro Lys Gly 
        275                 280                 285             


Pro Pro Ser Gly Ser Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys 
    290                 295                 300                 


His Lys Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn 
305                 310                 315                 320 


Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp 
                325                 330                 335     


Arg Leu Pro Asp Thr 
            340     


<210>  46
<211>  1023
<212>  DNA
<213>  Coding sequence for Monodelphis domestica FGE

<400>  46
gccgcccgag gtctgggttc cgaggccggt tccgccgccg ccgacgccgc tcaccctgct       60

ggcacttgtg gttgtggttc ccctcagcga cccggcaccg ccgctcaccg atactctcga      120

gaggctaacg tggctgagcc tgcttctgcc gagcgacctg tgctgacttc gcagatggct      180

cacatccccg ccggtgtctt caccatggga actgacgagc cccagatcaa gcaggatgga      240

gagggacctg cccgacgagt tcgaattaac tcgttttaca tggacctcta cgaggtctcc      300

aacgctgagt tcgagcgatt tgttaactcc accggttacg tcactgaggc cgagaagttc      360

ggagactctt tcgtttttga ttccatgctg tctgaccagg tgaagtccga tatccatcag      420

gctgtggccg ctgccccctg gtggctccct gtcaagggag ctaactggcg acaccctgag      480

ggacctgact cctctattct gcaccgacga gatcatcccg tcctccacgt gtcttggaac      540

gacgctgtgg cctactgtac ctgggctgga aagcgactgc ctactgaggc tgagtgggag      600

tactcctgcc gaggcggtct ggagaaccga ctctttccct ggggcaacaa gctccagcct      660

aagggtcagc actacgctaa catctggcag ggcgagttcc ccgtctccaa caccggagag      720

gacggctacc agggcaccgc tcctgtgact gcctttcccc ctaacggcta cggtctgtac      780

aacattgtgg gtaacgcttg ggagtggacc tccgactggt ggactgttca ccattctgcc      840

gacgagaccc tcgatcccaa gggaccccct tctggctcgg atcgagttaa gaagggaggc      900

tcgtacatgt gccacaagtc ctactgttac cgataccgat gcgctgcccg atctcagaac      960

acccctgact cttccgcctc taacctgggc ttccgatgtg ctgctgaccg actgcctgac     1020

act                                                                   1023


<210>  47
<211>  329
<212>  PRT
<213>  Gallus gallus FGE

<400>  47

Gly Lys Glu Thr Ala Pro Gly Gly Asn Cys Gly Cys Ser Ala Ser Arg 
1               5                   10                  15      


Ser Arg Gly Gly Glu Arg Glu Ala Val Ala Thr Val Arg Arg Tyr Ser 
            20                  25                  30          


Ala Ala Ala Asn Asp Gly Arg Ser Ser Gly Arg Gly Pro Met Val Ala 
        35                  40                  45              


Ile Pro Gly Gly Val Phe Thr Met Gly Thr Asp Glu Pro Glu Ile Gln 
    50                  55                  60                  


Gln Asp Gly Glu Trp Pro Ala Arg Arg Val His Val Asn Ser Phe Tyr 
65                  70                  75                  80  


Met Asp Gln Tyr Glu Val Ser Asn Gln Glu Phe Glu Arg Phe Val Asn 
                85                  90                  95      


Ser Thr Gly Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val 
            100                 105                 110         


Phe Glu Gly Met Leu Ser Glu Glu Val Lys Ala Glu Ile His Gln Ala 
        115                 120                 125             


Val Ala Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg 
    130                 135                 140                 


Gln Pro Glu Gly Pro Gly Ser Ser Ile Leu Ser Arg Met Asp His Pro 
145                 150                 155                 160 


Val Leu His Val Ser Trp Asn Asp Ala Val Ala Phe Cys Thr Trp Ala 
                165                 170                 175     


Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Tyr Gly Cys Arg Gly 
            180                 185                 190         


Gly Leu Glu Lys Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys 
        195                 200                 205             


Gly Gln His Tyr Ala Asn Ile Trp Gln Gly Val Phe Pro Thr Asn Asn 
    210                 215                 220                 


Thr Ala Glu Asp Gly Tyr Lys Gly Thr Ala Pro Val Thr Ala Phe Pro 
225                 230                 235                 240 


Pro Asn Gly Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp 
                245                 250                 255     


Thr Ser Asp Trp Trp Ala Val His His Ser Ala Asp Glu Ala His Asn 
            260                 265                 270         


Pro Lys Gly Pro Ser Ser Gly Thr Asp Arg Val Lys Lys Gly Gly Ser 
        275                 280                 285             


Tyr Met Cys His Lys Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg 
    290                 295                 300                 


Ser Gln Asn Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys 
305                 310                 315                 320 


Ala Ala Asp Ala Leu Pro Asp Pro Gln 
                325                 


<210>  48
<211>  987
<212>  DNA
<213>  Coding sequence for Gallus gallus FGE

<400>  48
ggcaaggaga ctgcccctgg cggtaactgc ggttgttctg cttcccgatc ccgaggtgga       60

gagcgagagg ccgttgctac tgtccgacga tactccgccg ctgccaacga cggccgatcc      120

tctggccgag gtcccatggt ggctatccct ggcggtgttt tcaccatggg aactgacgag      180

cccgagattc agcaggatgg cgagtggcct gctcgacgag tccacgtgaa ctcgttttac      240

atggaccagt acgaggtttc taaccaggag ttcgagcgat ttgtcaactc taccggatac      300

ctgactgagg ccgagaagtt cggcgactct ttcgtttttg agggaatgct ctcggaggaa      360

gtcaaggccg agatccatca ggctgttgct gccgctcctt ggtggctgcc tgtgaagggt      420

gctaactggc gacagcctga gggacctggc tcgtccattc tgtcccgaat ggaccacccc      480

gttctccatg tctcttggaa cgatgccgtc gctttctgta cctgggctgg caagcgactg      540

cctactgagg ctgagtggga gtacggatgc cgaggcggcc tggagaagcg actctttccc      600

tggggcaaca agctccagcc taagggtcag cactacgcca acatctggca gggcgtcttc      660

cccaccaaca acactgctga ggacggctac aagggcaccg cccctgtgac tgcttttccc      720

cctaacggtt acggactgta caacattgtg ggtaacgcct gggagtggac ctctgactgg      780

tgggctgttc accattctgc cgatgaggct cacaacccca agggaccttc ttcgggcacc      840

gaccgagtga agaagggtgg atcgtacatg tgccataagt cctactgtta ccgataccga      900

tgcgccgctc gatcccagaa cacccccgat tcctctgcct ctaacctcgg tttccgatgt      960

gccgccgacg ccctccccga ccctcag                                          987


<210>  49
<211>  312
<212>  PRT
<213>  Dendroctonus ponderosa FGE

<400>  49

Ile Cys Asp Cys Gly Cys Ser Leu Asn Arg Asp Gly Gln Cys Asn Ser 
1               5                   10                  15      


Glu Asp Asn Glu Ile Asn Pro Ser Gln Lys Tyr Lys Arg Asp Leu Asn 
            20                  25                  30          


Glu Asn Pro Ala Asp Asn Phe Asp Lys Ser Gln Met Ala Leu Ile Gly 
        35                  40                  45              


Lys Gly Ile Phe Glu Met Gly Thr Asn Lys Pro Val Phe Pro Ser Asp 
    50                  55                  60                  


Phe Glu Gly Pro Ala Arg Asn Val Thr Ile Glu Asn Ser Phe Tyr Leu 
65                  70                  75                  80  


Asp Leu Tyr Glu Val Ser Asn Gln Gln Phe Tyr Asp Phe Val Arg Thr 
                85                  90                  95      


Thr Asn Tyr Lys Thr Glu Ala Glu Gln Phe Gly Asp Ser Phe Val Phe 
            100                 105                 110         


Glu Met Ser Leu Pro Glu Asn Gln Arg Asn Glu His Gln Asp Ile Arg 
        115                 120                 125             


Ala Ala Gln Ala Pro Trp Trp Ile Lys Leu Pro Asp Ala Tyr Trp Lys 
    130                 135                 140                 


His Pro Glu Gly Pro Lys Ser Thr Ile Glu Asp Arg Met Asn His Pro 
145                 150                 155                 160 


Val Ala His Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Glu Tyr Val 
                165                 170                 175     


Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Met Ala Cys Arg Gly 
            180                 185                 190         


Gly Leu Arg Gln Lys Met Tyr Pro Trp Gly Asn Lys Leu Gln Pro Lys 
        195                 200                 205             


Gly Gln His Trp Ala Asn Ile Trp Gln Gly Glu Phe Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ala Glu Asp Gly Tyr Ile Phe Thr Cys Pro Val Asp Lys Phe Pro 
225                 230                 235                 240 


Pro Asn Gln Phe Gly Leu Tyr Asn Met Ala Gly Asn Val Trp Glu Trp 
                245                 250                 255     


Val Gln Asp Asp Trp Gln Thr Asp Pro Gln Asn Ser Arg Val Lys Lys 
            260                 265                 270         


Gly Gly Ser Phe Leu Cys His Gln Ser Tyr Cys Trp Arg Tyr Arg Cys 
        275                 280                 285             


Ala Ala Arg Ser Phe Asn Thr Lys Asp Ser Ser Ala Ala Asn Leu Gly 
    290                 295                 300                 


Phe Arg Cys Ala Ala Asp Ala Arg 
305                 310         


<210>  50
<211>  936
<212>  DNA
<213>  Coding sequence for the Dendroctonus ponderosa FGE

<400>  50
atttgcgact gcggctgctc cctgaaccga gacggccagt gtaactccga ggacaacgag       60

attaacccct cccagaagta caagcgagac ctgaacgaga accccgccga caacttcgat      120

aagtctcaga tggctctcat cggcaaggga atttttgaga tgggcaccaa caagcccgtt      180

ttcccttcgg actttgaggg tcctgcccga aacgtcacta tcgagaactc cttctacctg      240

gacctctacg aggtctctaa ccagcagttc tacgattttg tgcgaaccac taactacaag      300

accgaggctg agcagttcgg tgactcgttc gtctttgaga tgtccctgcc cgagaaccag      360

cgaaacgagc accaggacat ccgagctgct caggctcctt ggtggattaa gctccctgat      420

gcttactgga agcatcccga gggacctaag tcgaccattg aggaccgaat gaaccacccc      480

gtcgcccatg tgtcctggaa cgatgccgtg gcttactgtg agtacgttgg caagcgactg      540

cctactgagg ctgagtggga gatggcttgc cgaggcggtc tgcgacagaa gatgtacccc      600

tggggaaaca agctccagcc taagggccag cactgggcca acatctggca gggagagttc      660

cccaaggaga acaccgctga ggacggatac atttttactt gtcctgtgga taagttccct      720

cccaaccagt ttggcctcta caacatggcc ggtaacgttt gggagtgggt ccaggacgat      780

tggcagaccg acccccagaa ctcccgagtt aagaagggag gctctttcct gtgccatcag      840

tcgtactgtt ggcgataccg atgcgccgct cgatctttca acaccaagga ctcctctgcc      900

gctaacctcg gattccgatg tgctgctgac gcccga                                936


<210>  51
<211>  284
<212>  PRT
<213>  Columba livia FGE

<400>  51

Met Val Val Ile Pro Gly Gly Val Phe Thr Met Gly Thr Asp Glu Pro 
1               5                   10                  15      


Ala Ile Gln Gln Asp Gly Glu Trp Pro Val Arg Lys Val His Val Asn 
            20                  25                  30          


Ser Phe Tyr Met Asp Arg Tyr Glu Val Ser Asn Glu Asp Phe Glu Arg 
        35                  40                  45              


Phe Val Asn Ser Thr Gly Tyr Val Thr Glu Ala Glu Lys Phe Gly Asp 
    50                  55                  60                  


Ser Phe Val Phe Glu Gly Met Leu Ser Glu Glu Val Lys Ala Glu Ile 
65                  70                  75                  80  


His Gln Ala Val Ala Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala 
                85                  90                  95      


Asn Trp Lys His Pro Glu Gly Pro Asp Ser Asn Ile Ser Asn Arg Met 
            100                 105                 110         


Asp His Pro Val Leu His Val Ser Trp Asn Asp Ala Val Ala Phe Cys 
        115                 120                 125             


Thr Trp Ala Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser 
    130                 135                 140                 


Cys Arg Gly Gly Leu Glu Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu 
145                 150                 155                 160 


Gln Pro Lys Gly Gln His Tyr Ala Asn Ile Trp Gln Gly Val Phe Pro 
                165                 170                 175     


Thr Asn Asn Thr Ala Glu Asp Gly Tyr Lys Gly Thr Ala Pro Val Thr 
            180                 185                 190         


Ala Phe Pro Pro Asn Gly Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala 
        195                 200                 205             


Trp Glu Trp Thr Ala Asp Trp Trp Ala Val His His Ser Thr Glu Glu 
    210                 215                 220                 


Val His Asn Pro Lys Gly Pro Ser Ser Gly Thr Asp Arg Val Lys Lys 
225                 230                 235                 240 


Gly Gly Ser Tyr Met Cys His Lys Ser Tyr Cys Tyr Arg Tyr Arg Cys 
                245                 250                 255     


Ala Ala Arg Ser Gln Asn Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly 
            260                 265                 270         


Phe Arg Cys Ala Ala Asp Ala Ser Pro Glu Leu Pro 
        275                 280                 


<210>  52
<211>  852
<212>  DNA
<213>  Coding sequence for Columba livia FGE

<400>  52
atggtcgtta ttcccggagg agtttttact atgggtactg atgagcccgc tatccagcag       60

gacggagagt ggcccgtgcg aaaggttcac gttaactctt tctacatgga ccgatacgag      120

gtctcgaacg aggatttcga gcgatttgtt aactccaccg gctacgtcac tgaggctgag      180

aagtttggtg actcgttcgt ctttgaggga atgctgtccg aggaagtcaa ggctgagatc      240

caccaggctg tggccgctgc cccctggtgg ctccctgtga agggagctaa ctggaagcat      300

cccgagggcc ctgactctaa catttcgaac cgaatggatc accccgtcct gcatgtgtcc      360

tggaacgatg ctgttgcctt ctgtacctgg gctggcaagc gactgcctac tgaggccgag      420

tgggagtact cttgccgagg cggtctggag aaccgactct ttccctgggg caacaagctg      480

cagcctaagg gtcagcacta cgctaacatc tggcagggtg tgttccccac caacaacact      540

gccgaggacg gctacaaggg caccgctcct gtgactgcct ttccccctaa cggttacgga      600

ctctacaaca ttgttggaaa cgcttgggag tggaccgctg actggtgggc tgtgcaccat      660

tctactgagg aagtccacaa ccccaaggga ccttcctctg gcaccgatcg agtcaagaag      720

ggaggctcct acatgtgcca taagtcttac tgttaccgat accgatgcgc tgcccgatcc      780

cagaacaccc ccgactcgtc cgcctctaac ctgggattcc gatgtgctgc cgacgcttcg      840

cctgagctgc cc                                                          852


<210>  53
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tupaia chinensis Lip2-TupFGE-His6-HDEL fusion construct

<400>  53

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Glu Glu Ala Arg Thr Gly Ala Gly Ala Thr Ser Ala Gln Gly Pro 
            20                  25                  30          


Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ser His Gly Ser Ser Ala 
        35                  40                  45              


Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Val Pro Gly Pro Val Pro 
    50                  55                  60                  


Gly Glu Arg Gln Pro Glu Ala Thr Lys Met Val Pro Ile Pro Ala Gly 
65                  70                  75                  80  


Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly Glu 
                85                  90                  95      


Ala Pro Ala Arg Arg Val Ala Ile Asp Ala Phe Tyr Met Asp Ala Tyr 
            100                 105                 110         


Glu Val Ser Asn Ala Glu Phe Glu Lys Phe Val Asn Ser Thr Gly Tyr 
        115                 120                 125             


Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly Met 
    130                 135                 140                 


Leu Ser Glu Gln Val Lys Thr Gly Ile Gln Gln Ala Val Ala Ala Ala 
145                 150                 155                 160 


Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu Gly 
                165                 170                 175     


Pro Asp Ser Thr Ile Leu His Arg Ala Asp His Pro Val Leu His Val 
            180                 185                 190         


Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg Leu 
        195                 200                 205             


Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu Gln Asn 
    210                 215                 220                 


Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Arg Gly Gln His Tyr 
225                 230                 235                 240 


Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Ala Glu Asp 
                245                 250                 255     


Gly Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly Tyr 
            260                 265                 270         


Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp Trp 
        275                 280                 285             


Trp Thr Val Tyr His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly Pro 
    290                 295                 300                 


Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys His 
305                 310                 315                 320 


Lys Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn Thr 
                325                 330                 335     


Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp Arg 
            340                 345                 350         


Leu Pro Thr His His His His His His His Asp Glu Leu 
        355                 360                 365 


<210>  54
<211>  1098
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the Lip2-TupFGE-His6-HDEL fusion protein

<400>  54
atgaagcttt ccaccatcct cttcacagcc tgcgctaccc tggctgccgc cgaggaagcc       60

cgaactggtg ctggtgctac ttctgctcag ggaccctgcg gttgcggtac tcctcagcga      120

cccggttctc acggctcgtc tgccgctgcc caccgatact ctcgagaggc taacgttcct      180

ggacctgtcc ccggagagcg acagcctgag gccaccaaga tggtccctat ccccgctggc      240

gtgttcacca tgggtactga cgatcctcag atcaagcagg acggtgaagc tcctgctcga      300

cgagttgcca ttgacgcttt ttacatggat gcctacgagg tgtccaacgc tgagttcgag      360

aagtttgtta actctaccgg atacctgact gaggccgaga agttcggaga ctccttcgtc      420

tttgagggca tgctctctga gcaggttaag accggcatcc agcaggctgt ggctgccgct      480

ccttggtggc tgcctgtgaa gggagctaac tggcgacatc ctgagggtcc cgactccact      540

attctgcacc gagctgatca tcctgtcctc cacgtgtctt ggaacgacgc cgtcgcttac      600

tgtacctggg ctggcaagcg actgcctact gaggctgagt gggagtactc ctgccgaggc      660

ggtctgcaga accgactctt cccttggggt aacaagctcc agccccgagg acagcactac      720

gccaacatct ggcagggaga gtttcctgtc accaacactg ctgaggacgg attccagggc      780

accgctcctg tggatgcttt tccccctaac ggttacggac tgtacaacat tgttggaaac      840

gcctgggagt ggacctcgga ctggtggact gtgtaccatt ccgttgagga gaccctcaac      900

cccaagggtc ccccttctgg aaaggatcga gtgaagaagg gaggctcgta catgtgccac      960

aagtcctact gttaccgata ccgatgcgcc gctcgatctc agaacacccc cgactcctct     1020

gcctcgaacc tcggattccg atgtgctgct gaccgactgc ccactcacca ccaccaccac     1080

caccacgacg agctgtaa                                                   1098


<210>  55
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monodelphis domestica Lip2-MdFGE-His6-HDEL fusion construct

<400>  55

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Ala Ala Arg Gly Leu Gly Ser Glu Ala Gly Ser Ala Ala Ala Asp 
            20                  25                  30          


Ala Ala His Pro Ala Gly Thr Cys Gly Cys Gly Ser Pro Gln Arg Pro 
        35                  40                  45              


Gly Thr Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Val Ala Glu Pro 
    50                  55                  60                  


Ala Ser Ala Glu Arg Pro Val Leu Thr Ser Gln Met Ala His Ile Pro 
65                  70                  75                  80  


Ala Gly Val Phe Thr Met Gly Thr Asp Glu Pro Gln Ile Lys Gln Asp 
                85                  90                  95      


Gly Glu Gly Pro Ala Arg Arg Val Arg Ile Asn Ser Phe Tyr Met Asp 
            100                 105                 110         


Leu Tyr Glu Val Ser Asn Ala Glu Phe Glu Arg Phe Val Asn Ser Thr 
        115                 120                 125             


Gly Tyr Val Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Asp 
    130                 135                 140                 


Ser Met Leu Ser Asp Gln Val Lys Ser Asp Ile His Gln Ala Val Ala 
145                 150                 155                 160 


Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro 
                165                 170                 175     


Glu Gly Pro Asp Ser Ser Ile Leu His Arg Arg Asp His Pro Val Leu 
            180                 185                 190         


His Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys 
        195                 200                 205             


Arg Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu 
    210                 215                 220                 


Glu Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln 
225                 230                 235                 240 


His Tyr Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Ser Asn Thr Gly 
                245                 250                 255     


Glu Asp Gly Tyr Gln Gly Thr Ala Pro Val Thr Ala Phe Pro Pro Asn 
            260                 265                 270         


Gly Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser 
        275                 280                 285             


Asp Trp Trp Thr Val His His Ser Ala Asp Glu Thr Leu Asp Pro Lys 
    290                 295                 300                 


Gly Pro Pro Ser Gly Ser Asp Arg Val Lys Lys Gly Gly Ser Tyr Met 
305                 310                 315                 320 


Cys His Lys Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln 
                325                 330                 335     


Asn Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala 
            340                 345                 350         


Asp Arg Leu Pro Asp Thr His His His His His His His Asp Glu Leu 
        355                 360                 365             


<210>  56
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the Lip2-MdFGE-His6-HDEL fusion protein

<400>  56
atgaagcttt ccaccatcct cttcacagcc tgcgctaccc tggctgccgc cgccgcccga       60

ggtctgggtt ccgaggccgg ttccgccgcc gccgacgccg ctcaccctgc tggcacttgt      120

ggttgtggtt cccctcagcg acccggcacc gccgctcacc gatactctcg agaggctaac      180

gtggctgagc ctgcttctgc cgagcgacct gtgctgactt cgcagatggc tcacatcccc      240

gccggtgtct tcaccatggg aactgacgag ccccagatca agcaggatgg agagggacct      300

gcccgacgag ttcgaattaa ctcgttttac atggacctct acgaggtctc caacgctgag      360

ttcgagcgat ttgttaactc caccggttac gtcactgagg ccgagaagtt cggagactct      420

ttcgtttttg attccatgct gtctgaccag gtgaagtccg atatccatca ggctgtggcc      480

gctgccccct ggtggctccc tgtcaaggga gctaactggc gacaccctga gggacctgac      540

tcctctattc tgcaccgacg agatcatccc gtcctccacg tgtcttggaa cgacgctgtg      600

gcctactgta cctgggctgg aaagcgactg cctactgagg ctgagtggga gtactcctgc      660

cgaggcggtc tggagaaccg actctttccc tggggcaaca agctccagcc taagggtcag      720

cactacgcta acatctggca gggcgagttc cccgtctcca acaccggaga ggacggctac      780

cagggcaccg ctcctgtgac tgcctttccc cctaacggct acggtctgta caacattgtg      840

ggtaacgctt gggagtggac ctccgactgg tggactgttc accattctgc cgacgagacc      900

ctcgatccca agggaccccc ttctggctcg gatcgagtta agaagggagg ctcgtacatg      960

tgccacaagt cctactgtta ccgataccga tgcgctgccc gatctcagaa cacccctgac     1020

tcttccgcct ctaacctggg cttccgatgt gctgctgacc gactgcctga cactcatcac     1080

catcatcacc accacgacga gctgtaa                                         1107


<210>  57
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gallus gallus Lip2-GgFGE-His6-HDEL fusion construct

<400>  57

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Gly Lys Glu Thr Ala Pro Gly Gly Asn Cys Gly Cys Ser Ala Ser 
            20                  25                  30          


Arg Ser Arg Gly Gly Glu Arg Glu Ala Val Ala Thr Val Arg Arg Tyr 
        35                  40                  45              


Ser Ala Ala Ala Asn Asp Gly Arg Ser Ser Gly Arg Gly Pro Met Val 
    50                  55                  60                  


Ala Ile Pro Gly Gly Val Phe Thr Met Gly Thr Asp Glu Pro Glu Ile 
65                  70                  75                  80  


Gln Gln Asp Gly Glu Trp Pro Ala Arg Arg Val His Val Asn Ser Phe 
                85                  90                  95      


Tyr Met Asp Gln Tyr Glu Val Ser Asn Gln Glu Phe Glu Arg Phe Val 
            100                 105                 110         


Asn Ser Thr Gly Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe 
        115                 120                 125             


Val Phe Glu Gly Met Leu Ser Glu Glu Val Lys Ala Glu Ile His Gln 
    130                 135                 140                 


Ala Val Ala Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp 
145                 150                 155                 160 


Arg Gln Pro Glu Gly Pro Gly Ser Ser Ile Leu Ser Arg Met Asp His 
                165                 170                 175     


Pro Val Leu His Val Ser Trp Asn Asp Ala Val Ala Phe Cys Thr Trp 
            180                 185                 190         


Ala Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Tyr Gly Cys Arg 
        195                 200                 205             


Gly Gly Leu Glu Lys Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro 
    210                 215                 220                 


Lys Gly Gln His Tyr Ala Asn Ile Trp Gln Gly Val Phe Pro Thr Asn 
225                 230                 235                 240 


Asn Thr Ala Glu Asp Gly Tyr Lys Gly Thr Ala Pro Val Thr Ala Phe 
                245                 250                 255     


Pro Pro Asn Gly Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu 
            260                 265                 270         


Trp Thr Ser Asp Trp Trp Ala Val His His Ser Ala Asp Glu Ala His 
        275                 280                 285             


Asn Pro Lys Gly Pro Ser Ser Gly Thr Asp Arg Val Lys Lys Gly Gly 
    290                 295                 300                 


Ser Tyr Met Cys His Lys Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala 
305                 310                 315                 320 


Arg Ser Gln Asn Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg 
                325                 330                 335     


Cys Ala Ala Asp Ala Leu Pro Asp Pro Gln His His His His His His 
            340                 345                 350         


His Asp Glu Leu 
        355     


<210>  58
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the Lip2-GgFGE-His6-HDEL fusion protein

<400>  58
atgaagcttt ccaccatcct cttcacagcc tgcgctaccc tggctgccgc cggcaaggag       60

actgcccctg gcggtaactg cggttgttct gcttcccgat cccgaggtgg agagcgagag      120

gccgttgcta ctgtccgacg atactccgcc gctgccaacg acggccgatc ctctggccga      180

ggtcccatgg tggctatccc tggcggtgtt ttcaccatgg gaactgacga gcccgagatt      240

cagcaggatg gcgagtggcc tgctcgacga gtccacgtga actcgtttta catggaccag      300

tacgaggttt ctaaccagga gttcgagcga tttgtcaact ctaccggata cctgactgag      360

gccgagaagt tcggcgactc tttcgttttt gagggaatgc tctcggagga agtcaaggcc      420

gagatccatc aggctgttgc tgccgctcct tggtggctgc ctgtgaaggg tgctaactgg      480

cgacagcctg agggacctgg ctcgtccatt ctgtcccgaa tggaccaccc cgttctccat      540

gtctcttgga acgatgccgt cgctttctgt acctgggctg gcaagcgact gcctactgag      600

gctgagtggg agtacggatg ccgaggcggc ctggagaagc gactctttcc ctggggcaac      660

aagctccagc ctaagggtca gcactacgcc aacatctggc agggcgtctt ccccaccaac      720

aacactgctg aggacggcta caagggcacc gcccctgtga ctgcttttcc ccctaacggt      780

tacggactgt acaacattgt gggtaacgcc tgggagtgga cctctgactg gtgggctgtt      840

caccattctg ccgatgaggc tcacaacccc aagggacctt cttcgggcac cgaccgagtg      900

aagaagggtg gatcgtacat gtgccataag tcctactgtt accgataccg atgcgccgct      960

cgatcccaga acacccccga ttcctctgcc tctaacctcg gtttccgatg tgccgccgac     1020

gccctccccg accctcagca tcaccatcac catcatcacg acgagctgta g              1071


<210>  59
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dendroctonus ponderosa Lip2-DpFGE-His6-HDEL fusion construct

<400>  59

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Ile Cys Asp Cys Gly Cys Ser Leu Asn Arg Asp Gly Gln Cys Asn 
            20                  25                  30          


Ser Glu Asp Asn Glu Ile Asn Pro Ser Gln Lys Tyr Lys Arg Asp Leu 
        35                  40                  45              


Asn Glu Asn Pro Ala Asp Asn Phe Asp Lys Ser Gln Met Ala Leu Ile 
    50                  55                  60                  


Gly Lys Gly Ile Phe Glu Met Gly Thr Asn Lys Pro Val Phe Pro Ser 
65                  70                  75                  80  


Asp Phe Glu Gly Pro Ala Arg Asn Val Thr Ile Glu Asn Ser Phe Tyr 
                85                  90                  95      


Leu Asp Leu Tyr Glu Val Ser Asn Gln Gln Phe Tyr Asp Phe Val Arg 
            100                 105                 110         


Thr Thr Asn Tyr Lys Thr Glu Ala Glu Gln Phe Gly Asp Ser Phe Val 
        115                 120                 125             


Phe Glu Met Ser Leu Pro Glu Asn Gln Arg Asn Glu His Gln Asp Ile 
    130                 135                 140                 


Arg Ala Ala Gln Ala Pro Trp Trp Ile Lys Leu Pro Asp Ala Tyr Trp 
145                 150                 155                 160 


Lys His Pro Glu Gly Pro Lys Ser Thr Ile Glu Asp Arg Met Asn His 
                165                 170                 175     


Pro Val Ala His Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Glu Tyr 
            180                 185                 190         


Val Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Met Ala Cys Arg 
        195                 200                 205             


Gly Gly Leu Arg Gln Lys Met Tyr Pro Trp Gly Asn Lys Leu Gln Pro 
    210                 215                 220                 


Lys Gly Gln His Trp Ala Asn Ile Trp Gln Gly Glu Phe Pro Lys Glu 
225                 230                 235                 240 


Asn Thr Ala Glu Asp Gly Tyr Ile Phe Thr Cys Pro Val Asp Lys Phe 
                245                 250                 255     


Pro Pro Asn Gln Phe Gly Leu Tyr Asn Met Ala Gly Asn Val Trp Glu 
            260                 265                 270         


Trp Val Gln Asp Asp Trp Gln Thr Asp Pro Gln Asn Ser Arg Val Lys 
        275                 280                 285             


Lys Gly Gly Ser Phe Leu Cys His Gln Ser Tyr Cys Trp Arg Tyr Arg 
    290                 295                 300                 


Cys Ala Ala Arg Ser Phe Asn Thr Lys Asp Ser Ser Ala Ala Asn Leu 
305                 310                 315                 320 


Gly Phe Arg Cys Ala Ala Asp Ala Arg His His His His His His His 
                325                 330                 335     


Asp Glu Leu 
            


<210>  60
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the Lip2-DpFGE-His6-HDEL fusion protein

<400>  60
atgaagcttt ccaccatcct cttcacagcc tgcgctaccc tggctgccgc catttgcgac       60

tgcggctgct ccctgaaccg agacggccag tgtaactccg aggacaacga gattaacccc      120

tcccagaagt acaagcgaga cctgaacgag aaccccgccg acaacttcga taagtctcag      180

atggctctca tcggcaaggg aatttttgag atgggcacca acaagcccgt tttcccttcg      240

gactttgagg gtcctgcccg aaacgtcact atcgagaact ccttctacct ggacctctac      300

gaggtctcta accagcagtt ctacgatttt gtgcgaacca ctaactacaa gaccgaggct      360

gagcagttcg gtgactcgtt cgtctttgag atgtccctgc ccgagaacca gcgaaacgag      420

caccaggaca tccgagctgc tcaggctcct tggtggatta agctccctga tgcttactgg      480

aagcatcccg agggacctaa gtcgaccatt gaggaccgaa tgaaccaccc cgtcgcccat      540

gtgtcctgga acgatgccgt ggcttactgt gagtacgttg gcaagcgact gcctactgag      600

gctgagtggg agatggcttg ccgaggcggt ctgcgacaga agatgtaccc ctggggaaac      660

aagctccagc ctaagggcca gcactgggcc aacatctggc agggagagtt ccccaaggag      720

aacaccgctg aggacggata catttttact tgtcctgtgg ataagttccc tcccaaccag      780

tttggcctct acaacatggc cggtaacgtt tgggagtggg tccaggacga ttggcagacc      840

gacccccaga actcccgagt taagaaggga ggctctttcc tgtgccatca gtcgtactgt      900

tggcgatacc gatgcgccgc tcgatctttc aacaccaagg actcctctgc cgctaacctc      960

ggattccgat gtgctgctga cgcccgacac caccaccacc accaccacga cgagctgtag     1020


<210>  61
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Columba livia Lip2-ClFGE-His6-HDEL fusion construct

<400>  61

Met Lys Leu Ser Thr Ile Leu Phe Thr Ala Cys Ala Thr Leu Ala Ala 
1               5                   10                  15      


Ala Met Val Val Ile Pro Gly Gly Val Phe Thr Met Gly Thr Asp Glu 
            20                  25                  30          


Pro Ala Ile Gln Gln Asp Gly Glu Trp Pro Val Arg Lys Val His Val 
        35                  40                  45              


Asn Ser Phe Tyr Met Asp Arg Tyr Glu Val Ser Asn Glu Asp Phe Glu 
    50                  55                  60                  


Arg Phe Val Asn Ser Thr Gly Tyr Val Thr Glu Ala Glu Lys Phe Gly 
65                  70                  75                  80  


Asp Ser Phe Val Phe Glu Gly Met Leu Ser Glu Glu Val Lys Ala Glu 
                85                  90                  95      


Ile His Gln Ala Val Ala Ala Ala Pro Trp Trp Leu Pro Val Lys Gly 
            100                 105                 110         


Ala Asn Trp Lys His Pro Glu Gly Pro Asp Ser Asn Ile Ser Asn Arg 
        115                 120                 125             


Met Asp His Pro Val Leu His Val Ser Trp Asn Asp Ala Val Ala Phe 
    130                 135                 140                 


Cys Thr Trp Ala Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Tyr 
145                 150                 155                 160 


Ser Cys Arg Gly Gly Leu Glu Asn Arg Leu Phe Pro Trp Gly Asn Lys 
                165                 170                 175     


Leu Gln Pro Lys Gly Gln His Tyr Ala Asn Ile Trp Gln Gly Val Phe 
            180                 185                 190         


Pro Thr Asn Asn Thr Ala Glu Asp Gly Tyr Lys Gly Thr Ala Pro Val 
        195                 200                 205             


Thr Ala Phe Pro Pro Asn Gly Tyr Gly Leu Tyr Asn Ile Val Gly Asn 
    210                 215                 220                 


Ala Trp Glu Trp Thr Ala Asp Trp Trp Ala Val His His Ser Thr Glu 
225                 230                 235                 240 


Glu Val His Asn Pro Lys Gly Pro Ser Ser Gly Thr Asp Arg Val Lys 
                245                 250                 255     


Lys Gly Gly Ser Tyr Met Cys His Lys Ser Tyr Cys Tyr Arg Tyr Arg 
            260                 265                 270         


Cys Ala Ala Arg Ser Gln Asn Thr Pro Asp Ser Ser Ala Ser Asn Leu 
        275                 280                 285             


Gly Phe Arg Cys Ala Ala Asp Ala Ser Pro Glu Leu Pro His His His 
    290                 295                 300                 


His His His His Asp Glu Leu 
305                 310     


<210>  62
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the Lip2-ClFGE-His6-HDEL fusion protein

<400>  62
atgaagcttt ccaccatcct cttcacagcc tgcgctaccc tggctgccgc catggtcgtt       60

attcccggag gagtttttac tatgggtact gatgagcccg ctatccagca ggacggagag      120

tggcccgtgc gaaaggttca cgttaactct ttctacatgg accgatacga ggtctcgaac      180

gaggatttcg agcgatttgt taactccacc ggctacgtca ctgaggctga gaagtttggt      240

gactcgttcg tctttgaggg aatgctgtcc gaggaagtca aggctgagat ccaccaggct      300

gtggccgctg ccccctggtg gctccctgtg aagggagcta actggaagca tcccgagggc      360

cctgactcta acatttcgaa ccgaatggat caccccgtcc tgcatgtgtc ctggaacgat      420

gctgttgcct tctgtacctg ggctggcaag cgactgccta ctgaggccga gtgggagtac      480

tcttgccgag gcggtctgga gaaccgactc tttccctggg gcaacaagct gcagcctaag      540

ggtcagcact acgctaacat ctggcagggt gtgttcccca ccaacaacac tgccgaggac      600

ggctacaagg gcaccgctcc tgtgactgcc tttcccccta acggttacgg actctacaac      660

attgttggaa acgcttggga gtggaccgct gactggtggg ctgtgcacca ttctactgag      720

gaagtccaca accccaaggg accttcctct ggcaccgatc gagtcaagaa gggaggctcc      780

tacatgtgcc ataagtctta ctgttaccga taccgatgcg ctgcccgatc ccagaacacc      840

cccgactcgt ccgcctctaa cctgggattc cgatgtgctg ccgacgcttc gcctgagctg      900

ccccaccacc accatcacca tcacgacgag ctgtaa                                936


<210>  63
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MNS1-ClFGE fusion construct

<400>  63

Met Ser Phe Asn Ile Pro Lys Thr Thr Pro Asn Phe Ser Ala Lys Ala 
1               5                   10                  15      


Arg Lys Leu Glu Asp Gln Leu Trp Gln Ala Ser Gly Leu Glu Lys Ser 
            20                  25                  30          


Lys Asp Ser Thr Leu Pro Leu Tyr Lys Asp Lys Pro Tyr Gly Glu Gly 
        35                  40                  45              


Phe Val Ala Arg Thr Thr Ser Gly Arg Arg Arg Arg Asn Ile Ile Tyr 
    50                  55                  60                  


Gly Val Val Val Gly Leu Leu Phe Trp Ala Ile Tyr Thr Phe Ser Arg 
65                  70                  75                  80  


Ser Leu Asp Gly Asn Val Ser Leu Lys Asp Gly Ile Lys Asp Tyr Glu 
                85                  90                  95      


Phe Lys Gly Trp Lys Gly Arg Gly Lys Pro Lys Thr Asn Trp Val Ala 
            100                 105                 110         


Glu Gln Asn Ala Val Lys Gln Ala Phe Val Asp Ser Trp Asn Gly Tyr 
        115                 120                 125             


His Lys Tyr Ala Trp Gly Lys Asp Val Tyr Lys Pro Gln Thr Lys Thr 
    130                 135                 140                 


Gly Lys Asn Met Gly Pro Lys Pro Leu Gly Trp Phe Ile Val Asp Ser 
145                 150                 155                 160 


Leu Asp Ser Met Val Val Ile Pro Gly Gly Val Phe Thr Met Gly Thr 
                165                 170                 175     


Asp Glu Pro Ala Ile Gln Gln Asp Gly Glu Trp Pro Val Arg Lys Val 
            180                 185                 190         


His Val Asn Ser Phe Tyr Met Asp Arg Tyr Glu Val Ser Asn Glu Asp 
        195                 200                 205             


Phe Glu Arg Phe Val Asn Ser Thr Gly Tyr Val Thr Glu Ala Glu Lys 
    210                 215                 220                 


Phe Gly Asp Ser Phe Val Phe Glu Gly Met Leu Ser Glu Glu Val Lys 
225                 230                 235                 240 


Ala Glu Ile His Gln Ala Val Ala Ala Ala Pro Trp Trp Leu Pro Val 
                245                 250                 255     


Lys Gly Ala Asn Trp Lys His Pro Glu Gly Pro Asp Ser Asn Ile Ser 
            260                 265                 270         


Asn Arg Met Asp His Pro Val Leu His Val Ser Trp Asn Asp Ala Val 
        275                 280                 285             


Ala Phe Cys Thr Trp Ala Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp 
    290                 295                 300                 


Glu Tyr Ser Cys Arg Gly Gly Leu Glu Asn Arg Leu Phe Pro Trp Gly 
305                 310                 315                 320 


Asn Lys Leu Gln Pro Lys Gly Gln His Tyr Ala Asn Ile Trp Gln Gly 
                325                 330                 335     


Val Phe Pro Thr Asn Asn Thr Ala Glu Asp Gly Tyr Lys Gly Thr Ala 
            340                 345                 350         


Pro Val Thr Ala Phe Pro Pro Asn Gly Tyr Gly Leu Tyr Asn Ile Val 
        355                 360                 365             


Gly Asn Ala Trp Glu Trp Thr Ala Asp Trp Trp Ala Val His His Ser 
    370                 375                 380                 


Thr Glu Glu Val His Asn Pro Lys Gly Pro Ser Ser Gly Thr Asp Arg 
385                 390                 395                 400 


Val Lys Lys Gly Gly Ser Tyr Met Cys His Lys Ser Tyr Cys Tyr Arg 
                405                 410                 415     


Tyr Arg Cys Ala Ala Arg Ser Gln Asn Thr Pro Asp Ser Ser Ala Ser 
            420                 425                 430         


Asn Leu Gly Phe Arg Cys Ala Ala Asp Ala Ser Pro Glu Leu Pro 
        435                 440                 445         


<210>  64
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the MNS1-ClFGE fusion protein

<400>  64
atgtcgttca acattcccaa gaccaccccc aacttctcgg ctaaggctcg aaagctggag       60

gatcagctct ggcaggcttc tggactcgag aagtccaagg actctaccct gcctctctac      120

aaggataagc cctacggaga gggcttcgtg gctcgaacca cttccggccg acgacgacga      180

aacatcatct acggcgtcgt ggttggtctg ctcttctggg ccatctacac cttttctcga      240

tcgctggacg gtaacgtctc tctcaaggac ggaattaagg attacgagtt caagggctgg      300

aagggtcgag gaaagcccaa gactaactgg gtggccgagc agaacgctgt taagcaggcc      360

tttgtcgact cctggaacgg ctaccataag tacgcctggg gcaaggatgt gtacaagccc      420

cagaccaaga ctggaaagaa catgggcccc aagcctctgg gatggttcat cgtggactct      480

ctggattcca tggtcgttat tcccggagga gtttttacta tgggtactga tgagcccgct      540

atccagcagg acggagagtg gcccgtgcga aaggttcacg ttaactcttt ctacatggac      600

cgatacgagg tctcgaacga ggatttcgag cgatttgtta actccaccgg ctacgtcact      660

gaggctgaga agtttggtga ctcgttcgtc tttgagggaa tgctgtccga ggaagtcaag      720

gctgagatcc accaggctgt ggccgctgcc ccctggtggc tccctgtgaa gggagctaac      780

tggaagcatc ccgagggccc tgactctaac atttcgaacc gaatggatca ccccgtcctg      840

catgtgtcct ggaacgatgc tgttgccttc tgtacctggg ctggcaagcg actgcctact      900

gaggccgagt gggagtactc ttgccgaggc ggtctggaga accgactctt tccctggggc      960

aacaagctgc agcctaaggg tcagcactac gctaacatct ggcagggtgt gttccccacc     1020

aacaacactg ccgaggacgg ctacaagggc accgctcctg tgactgcctt tccccctaac     1080

ggttacggac tctacaacat tgttggaaac gcttgggagt ggaccgctga ctggtgggct     1140

gtgcaccatt ctactgagga agtccacaac cccaagggac cttcctctgg caccgatcga     1200

gtcaagaagg gaggctccta catgtgccat aagtcttact gttaccgata ccgatgcgct     1260

gcccgatccc agaacacccc cgactcgtcc gcctctaacc tgggattccg atgtgctgcc     1320

gacgcttcgc ctgagctgcc c                                               1341


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-myc protein tag

<400>  65

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  66
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the c-myc protein tag

<400>  66
gaacaaaaac tcatctcaga agaggatctg taa                                    33


<210>  67
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MNS1-ClFGE-c-myc fusion construct

<400>  67

Met Ser Phe Asn Ile Pro Lys Thr Thr Pro Asn Phe Ser Ala Lys Ala 
1               5                   10                  15      


Arg Lys Leu Glu Asp Gln Leu Trp Gln Ala Ser Gly Leu Glu Lys Ser 
            20                  25                  30          


Lys Asp Ser Thr Leu Pro Leu Tyr Lys Asp Lys Pro Tyr Gly Glu Gly 
        35                  40                  45              


Phe Val Ala Arg Thr Thr Ser Gly Arg Arg Arg Arg Asn Ile Ile Tyr 
    50                  55                  60                  


Gly Val Val Val Gly Leu Leu Phe Trp Ala Ile Tyr Thr Phe Ser Arg 
65                  70                  75                  80  


Ser Leu Asp Gly Asn Val Ser Leu Lys Asp Gly Ile Lys Asp Tyr Glu 
                85                  90                  95      


Phe Lys Gly Trp Lys Gly Arg Gly Lys Pro Lys Thr Asn Trp Val Ala 
            100                 105                 110         


Glu Gln Asn Ala Val Lys Gln Ala Phe Val Asp Ser Trp Asn Gly Tyr 
        115                 120                 125             


His Lys Tyr Ala Trp Gly Lys Asp Val Tyr Lys Pro Gln Thr Lys Thr 
    130                 135                 140                 


Gly Lys Asn Met Gly Pro Lys Pro Leu Gly Trp Phe Ile Val Asp Ser 
145                 150                 155                 160 


Leu Asp Ser Met Val Val Ile Pro Gly Gly Val Phe Thr Met Gly Thr 
                165                 170                 175     


Asp Glu Pro Ala Ile Gln Gln Asp Gly Glu Trp Pro Val Arg Lys Val 
            180                 185                 190         


His Val Asn Ser Phe Tyr Met Asp Arg Tyr Glu Val Ser Asn Glu Asp 
        195                 200                 205             


Phe Glu Arg Phe Val Asn Ser Thr Gly Tyr Val Thr Glu Ala Glu Lys 
    210                 215                 220                 


Phe Gly Asp Ser Phe Val Phe Glu Gly Met Leu Ser Glu Glu Val Lys 
225                 230                 235                 240 


Ala Glu Ile His Gln Ala Val Ala Ala Ala Pro Trp Trp Leu Pro Val 
                245                 250                 255     


Lys Gly Ala Asn Trp Lys His Pro Glu Gly Pro Asp Ser Asn Ile Ser 
            260                 265                 270         


Asn Arg Met Asp His Pro Val Leu His Val Ser Trp Asn Asp Ala Val 
        275                 280                 285             


Ala Phe Cys Thr Trp Ala Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp 
    290                 295                 300                 


Glu Tyr Ser Cys Arg Gly Gly Leu Glu Asn Arg Leu Phe Pro Trp Gly 
305                 310                 315                 320 


Asn Lys Leu Gln Pro Lys Gly Gln His Tyr Ala Asn Ile Trp Gln Gly 
                325                 330                 335     


Val Phe Pro Thr Asn Asn Thr Ala Glu Asp Gly Tyr Lys Gly Thr Ala 
            340                 345                 350         


Pro Val Thr Ala Phe Pro Pro Asn Gly Tyr Gly Leu Tyr Asn Ile Val 
        355                 360                 365             


Gly Asn Ala Trp Glu Trp Thr Ala Asp Trp Trp Ala Val His His Ser 
    370                 375                 380                 


Thr Glu Glu Val His Asn Pro Lys Gly Pro Ser Ser Gly Thr Asp Arg 
385                 390                 395                 400 


Val Lys Lys Gly Gly Ser Tyr Met Cys His Lys Ser Tyr Cys Tyr Arg 
                405                 410                 415     


Tyr Arg Cys Ala Ala Arg Ser Gln Asn Thr Pro Asp Ser Ser Ala Ser 
            420                 425                 430         


Asn Leu Gly Phe Arg Cys Ala Ala Asp Ala Ser Pro Glu Leu Pro Glu 
        435                 440                 445             


Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    450                 455         


<210>  68
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for the MNS1-ClFGE-c-myc fusion protein

<400>  68
atgtcgttca acattcccaa gaccaccccc aacttctcgg ctaaggctcg aaagctggag       60

gatcagctct ggcaggcttc tggactcgag aagtccaagg actctaccct gcctctctac      120

aaggataagc cctacggaga gggcttcgtg gctcgaacca cttccggccg acgacgacga      180

aacatcatct acggcgtcgt ggttggtctg ctcttctggg ccatctacac cttttctcga      240

tcgctggacg gtaacgtctc tctcaaggac ggaattaagg attacgagtt caagggctgg      300

aagggtcgag gaaagcccaa gactaactgg gtggccgagc agaacgctgt taagcaggcc      360

tttgtcgact cctggaacgg ctaccataag tacgcctggg gcaaggatgt gtacaagccc      420

cagaccaaga ctggaaagaa catgggcccc aagcctctgg gatggttcat cgtggactct      480

ctggattcca tggtcgttat tcccggagga gtttttacta tgggtactga tgagcccgct      540

atccagcagg acggagagtg gcccgtgcga aaggttcacg ttaactcttt ctacatggac      600

cgatacgagg tctcgaacga ggatttcgag cgatttgtta actccaccgg ctacgtcact      660

gaggctgaga agtttggtga ctcgttcgtc tttgagggaa tgctgtccga ggaagtcaag      720

gctgagatcc accaggctgt ggccgctgcc ccctggtggc tccctgtgaa gggagctaac      780

tggaagcatc ccgagggccc tgactctaac atttcgaacc gaatggatca ccccgtcctg      840

catgtgtcct ggaacgatgc tgttgccttc tgtacctggg ctggcaagcg actgcctact      900

gaggccgagt gggagtactc ttgccgaggc ggtctggaga accgactctt tccctggggc      960

aacaagctgc agcctaaggg tcagcactac gctaacatct ggcagggtgt gttccccacc     1020

aacaacactg ccgaggacgg ctacaagggc accgctcctg tgactgcctt tccccctaac     1080

ggttacggac tctacaacat tgttggaaac gcttgggagt ggaccgctga ctggtgggct     1140

gtgcaccatt ctactgagga agtccacaac cccaagggac cttcctctgg caccgatcga     1200

gtcaagaagg gaggctccta catgtgccat aagtcttact gttaccgata ccgatgcgct     1260

gcccgatccc agaacacccc cgactcgtcc gcctctaacc tgggattccg atgtgctgcc     1320

gacgcttcgc ctgagctgcc cgaacaaaaa ctcatctcag aagaggatct gtaa           1374


