               SEQUENCE LISTING

<110> Boehringer Ingelheim International GmbH

<120> Combination therapy for neoplasia treatment

<130> P01-2907 PCT

<160> 46

<170> BiSSAP 1.0

<210> 1
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 1
Asn Tyr Trp Met His 
1               5

<210> 2
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..17
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 2
Gly Ile Ser Gly Trp Ser Ser Trp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                   15    
Gly 
    

<210> 3
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..13
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 3
Phe Gly Ile Asp Ala Tyr Thr Lys Val Tyr Phe Asp Tyr 
1               5                   10            

<210> 4
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..11
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 4
Ser Gly Asp Asn Ile Pro Leu Lys Tyr Val Ser 
1               5                   10    

<210> 5
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..7
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 5
Asp Asp Asn Lys Arg Pro Ser 
1               5        

<210> 6
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..9
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 6
Gln Ser Trp Ala Ser Thr Gly Val Val 
1               5                

<210> 7
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..122
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 7
Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                   25                  30        
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ser Gly Ile Ser Gly Trp Ser Ser Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Phe Gly Ile Asp Ala Tyr Thr Lys Val Tyr Phe Asp Tyr Trp 
            100                  105                110        
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                  120        

<210> 8
<211> 107
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..107
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 8
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                   15    
Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Pro Leu Lys Tyr Val 
            20                   25                  30        
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile His 
        35                   40                  45            
Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                   55                  60                
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                   70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Ala Ser Thr Gly Val Val 
                85                   90                  95    
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                  105        

<210> 9
<211> 452
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..452
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 9
Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                   25                  30        
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ser Gly Ile Ser Gly Trp Ser Ser Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Phe Gly Ile Asp Ala Tyr Thr Lys Val Tyr Phe Asp Tyr Trp 
            100                  105                110        
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                  120                125            
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                  135                140                
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                  150                155                  160
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                  170                175    
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                  185                190        
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                  200                205            
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                  215                220                
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                  230                235                  240
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                  250                255    
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                  265                270        
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                  280                285            
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                  295                300                
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                  310                315                  320
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                  330                335    
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                  345                350        
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                  360                365            
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                  375                380                
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                  390                395                  400
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                  410                415    
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                  425                430        
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                  440                445            
Ser Pro Gly Lys 
    450        

<210> 10
<211> 212
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..212
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 10
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                   15    
Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Pro Leu Lys Tyr Val 
            20                   25                  30        
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile His 
        35                   40                  45            
Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                   55                  60                
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                   70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Ala Ser Thr Gly Val Val 
                85                   90                  95    
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                  105                110        
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                  120                125            
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                  135                140                
Thr Val Ala Trp Lys Gly Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                  150                155                  160
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                  170                175    
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                  185                190        
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                  200                205            
Thr Glu Cys Ser 
    210        

<210> 11
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 11
Asn Tyr Trp Met His 
1               5

<210> 12
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..17
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 12
Gly Ile Ser Gly Trp Ser Ser Trp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                   15    
Gly 
    

<210> 13
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..13
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 13
Phe Gly Ile Asp Ala Tyr Thr Lys Val Tyr Phe Asp Tyr 
1               5                   10            

<210> 14
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..11
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 14
Ser Gly Asp Asn Ile Pro Leu Lys Tyr Val Ser 
1               5                   10    

<210> 15
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..7
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 15
Asp Asp Asn Lys Arg Pro Ser 
1               5        

<210> 16
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..11
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 16
Ser Ser Trp Asp Thr Leu Asp Ile Phe Asn Val 
1               5                   10    

<210> 17
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..122
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 17
Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                   25                  30        
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ser Gly Ile Ser Gly Trp Ser Ser Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Phe Gly Ile Asp Ala Tyr Thr Lys Val Tyr Phe Asp Tyr Trp 
            100                  105                110        
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                  120        

<210> 18
<211> 109
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..109
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 18
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                   15    
Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Pro Leu Lys Tyr Val 
            20                   25                  30        
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile His 
        35                   40                  45            
Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                   55                  60                
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                   70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Thr Leu Asp Ile Phe 
                85                   90                  95    
Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                  105                

<210> 19
<211> 452
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..452
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 19
Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                   25                  30        
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ser Gly Ile Ser Gly Trp Ser Ser Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Phe Gly Ile Asp Ala Tyr Thr Lys Val Tyr Phe Asp Tyr Trp 
            100                  105                110        
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                  120                125            
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                  135                140                
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                  150                155                  160
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                  170                175    
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                  185                190        
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                  200                205            
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                  215                220                
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                  230                235                  240
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                  250                255    
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                  265                270        
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                  280                285            
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                  295                300                
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                  310                315                  320
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                  330                335    
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                  345                350        
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                  360                365            
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                  375                380                
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                  390                395                  400
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                  410                415    
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                  425                430        
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                  440                445            
Ser Pro Gly Lys 
    450        

<210> 20
<211> 214
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..214
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 20
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                   15    
Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Pro Leu Lys Tyr Val 
            20                   25                  30        
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile His 
        35                   40                  45            
Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                   55                  60                
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                   70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Thr Leu Asp Ile Phe 
                85                   90                  95    
Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                  105                110        
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                  120                125            
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                  135                140                
Ala Val Thr Val Ala Trp Lys Gly Asp Ser Ser Pro Val Lys Ala Gly 
145                  150                155                  160
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                  170                175    
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                  185                190        
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                  200                205            
Ala Pro Thr Glu Cys Ser 
    210                

<210> 21
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 21
Asn Tyr Trp Met His 
1               5

<210> 22
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..17
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 22
Gly Ile Ser Gly Trp Ser Ser Trp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                   15    
Gly 
    

<210> 23
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..13
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 23
Phe Gly Ile Asp Ala Tyr Thr Lys Val Tyr Phe Asp Tyr 
1               5                   10            

<210> 24
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..11
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 24
Ser Gly Asp Asn Ile Pro Leu Lys Tyr Val Ser 
1               5                   10    

<210> 25
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..7
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 25
Asp Asp Asn Lys Arg Pro Ser 
1               5        

<210> 26
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..11
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 26
Gln Ser Tyr Asp Tyr Phe Pro Lys Phe Val Val 
1               5                   10    

<210> 27
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..122
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 27
Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                   25                  30        
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ser Gly Ile Ser Gly Trp Ser Ser Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Phe Gly Ile Asp Ala Tyr Thr Lys Val Tyr Phe Asp Tyr Trp 
            100                  105                110        
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                  120        

<210> 28
<211> 109
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..109
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 28
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                   15    
Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Pro Leu Lys Tyr Val 
            20                   25                  30        
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile His 
        35                   40                  45            
Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                   55                  60                
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                   70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Tyr Phe Pro Lys Phe 
                85                   90                  95    
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                  105                

<210> 29
<211> 452
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..452
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 29
Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                   25                  30        
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ser Gly Ile Ser Gly Trp Ser Ser Trp Thr Tyr Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Phe Gly Ile Asp Ala Tyr Thr Lys Val Tyr Phe Asp Tyr Trp 
            100                  105                110        
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                  120                125            
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                  135                140                
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                  150                155                  160
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                  170                175    
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                  185                190        
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                  200                205            
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                  215                220                
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                  230                235                  240
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                  250                255    
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                  265                270        
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                  280                285            
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                  295                300                
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                  310                315                  320
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                  330                335    
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                  345                350        
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                  360                365            
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                  375                380                
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                  390                395                  400
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                  410                415    
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                  425                430        
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                  440                445            
Ser Pro Gly Lys 
    450        

<210> 30
<211> 214
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..214
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 30
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                   15    
Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Pro Leu Lys Tyr Val 
            20                   25                  30        
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile His 
        35                   40                  45            
Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                   55                  60                
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                   70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Tyr Phe Pro Lys Phe 
                85                   90                  95    
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                  105                110        
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                  120                125            
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                  135                140                
Ala Val Thr Val Ala Trp Lys Gly Asp Ser Ser Pro Val Lys Ala Gly 
145                  150                155                  160
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                  170                175    
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                  185                190        
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                  200                205            
Ala Pro Thr Glu Cys Ser 
    210                

<210> 31
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 31
Ser Tyr Trp Met Ser 
1               5

<210> 32
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..17
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 32
Ser Ile Thr Ser Tyr Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                   15    
Gly 
    

<210> 33
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..8
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 33
Asn Met Tyr Thr His Phe Asp Ser 
1               5            

<210> 34
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..13
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 34
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ser Val Ser 
1               5                   10            

<210> 35
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..7
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 35
Asp Asn Ser Lys Arg Pro Ser 
1               5        

<210> 36
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..11
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 36
Gln Ser Arg Asp Thr Tyr Gly Tyr Tyr Trp Val 
1               5                   10    

<210> 37
<211> 117
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..117
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 37
Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                   25                  30        
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                   40                  45            
Ser Ser Ile Thr Ser Tyr Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Asn Met Tyr Thr His Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                  105                110        
Val Thr Val Ser Ser 
        115        

<210> 38
<211> 111
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..111
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 38
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                   15    
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                   25                  30        
Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                   40                  45            
Ile Tyr Asp Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                   55                  60                
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                   70                  75                  80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Arg Asp Thr Tyr Gly 
                85                   90                  95    
Tyr Tyr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                  105                110    

<210> 39
<211> 447
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..447
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 39
Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                   25                  30        
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                   40                  45            
Ser Ser Ile Thr Ser Tyr Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Asn Met Tyr Thr His Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                  105                110        
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                  120                125            
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                  135                140                
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                  150                155                  160
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                  170                175    
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                  185                190        
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                  200                205            
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                  215                220                
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                  230                235                  240
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                  250                255    
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                  265                270        
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                  280                285            
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                  295                300                
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                  310                315                  320
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                  330                335    
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                  345                350        
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                  360                365            
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                  375                380                
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                  390                395                  400
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                  410                415    
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                  425                430        
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                  440                445        

<210> 40
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..216
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 40
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                   15    
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                   25                  30        
Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                   40                  45            
Ile Tyr Asp Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                   55                  60                
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                   70                  75                  80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Arg Asp Thr Tyr Gly 
                85                   90                  95    
Tyr Tyr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                  105                110        
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                  120                125            
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                  135                140                
Pro Gly Ala Val Thr Val Ala Trp Lys Gly Asp Ser Ser Pro Val Lys 
145                  150                155                  160
Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                  170                175    
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                  185                190        
Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                  200                205            
Thr Val Ala Pro Thr Glu Cys Ser 
    210                  215    

<210> 41
<211> 121
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..121
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 41
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                   15    
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                   25                  30        
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                   40                  45            
Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                   55                  60                
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                   70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                  105                110        
Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                  120    

<210> 42
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..112
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 42
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                   15    
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Asn Asn 
            20                   25                  30        
His Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                   40                  45            
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                   55                  60                
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                   70                  75                  80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Thr Ser Leu 
                85                   90                  95    
Ser Ala Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                  105                110        

<210> 43
<211> 121
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..121
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 43
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                   15    
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                   25                  30        
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                   40                  45            
Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                   55                  60                
Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                   70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Arg Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                  105                110        
Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                  120    

<210> 44
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..112
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 44
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                   15    
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Asn Asn 
            20                   25                  30        
His Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                   40                  45            
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                   55                  60                
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                   70                  75                  80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Thr Ser Leu 
                85                   90                  95    
Ser Ala Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                  105                110        

<210> 45
<211> 450
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..450
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 45
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                   15    
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                   25                  30        
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                   40                  45            
Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Phe Tyr Ala Asp Ser Val 
    50                   55                  60                
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Thr Thr Leu Tyr 
65                   70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                   90                  95    
Ala Lys Asp Leu Gly Trp Ser Asp Ser Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                  105                110        
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                  120                125            
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                  135                140                
Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                  150                155                  160
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                  170                175    
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                  185                190        
Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                  200                205            
Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                  215                220                
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                  230                235                  240
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                  250                255    
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                  265                270        
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                  280                285            
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                  295                300                
Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                  310                315                  320
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                  330                335    
Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                  345                350        
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                  360                365            
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                  375                380                
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                  390                395                  400
Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                  410                415    
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                  425                430        
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                  440                445            
Pro Gly 
    450

<210> 46
<211> 214
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..214
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 46
Asp Ile Gln Met Thr Gln Phe Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                   15    
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                   25                  30        
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                   40                  45            
Tyr Ala Ala Ser Arg Leu His Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                   55                  60                
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                   70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Cys 
                85                   90                  95    
Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                  105                110        
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                  120                125            
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                  135                140                
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                  150                155                  160
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                  170                175    
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                  185                190        
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                  200                205            
Phe Asn Arg Gly Glu Cys 
    210                

