                         SEQUENCE LISTING

<110>  LOS ALAMOS NATIONAL SECURITY, LLC
 
<120>  BROAD SPECTRUM ANTIBIOTIC COMPOUNDS AND USE THEREOF

<130>  8472-87639-04

<150>  US 61/771,322
<151>  2013-03-01

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1855
<212>  PRT
<213>  Clostridium thermocellum

<400>  1

Met Asn Leu Asn Ser Asn Ile Lys Glu Arg Ile Asn Gln Leu Pro Val 
1               5                   10                  15      


Glu Lys Arg Glu Leu Ile Met Gln Leu Leu Lys Lys Gln Asn Asn Lys 
            20                  25                  30          


Arg Glu Ile Gln Asn Glu Glu Asp Lys Ile Thr Leu Cys His Arg Glu 
        35                  40                  45              


Lys Gly Cys Ile Asn Tyr Phe Pro Leu Ser Tyr Phe Gln Gln Gly Leu 
    50                  55                  60                  


Trp Phe Ile Asn Gln Leu Asp Pro Asn Asn Ser Ser Tyr Asn Ile Pro 
65                  70                  75                  80  


Leu Ala Tyr Arg Leu Val Gly Thr Leu Asn Lys Glu Ala Leu Lys Lys 
                85                  90                  95      


Ser Leu Glu Ile Ile Ile Asn Arg His Glu Val Leu Arg Thr Thr Phe 
            100                 105                 110         


Gln Glu Ile Asn Gly Glu Pro Phe Gln Val Ile Ser Pro Tyr Ser Lys 
        115                 120                 125             


Val Glu Leu Asn Ile Ile Asp Ile Ser His Ile Thr Gly Glu Asp Cys 
    130                 135                 140                 


Glu Lys Leu Ala Leu Glu Ser Ala Arg Asn Glu Ala Asn Arg Leu Phe 
145                 150                 155                 160 


Asp Leu Thr Lys Gly Pro Leu Ile Arg Phe Leu Leu Ile Cys Lys Ser 
                165                 170                 175     


Gln Thr Glu His Ile Phe Val Val Thr Val His His Ile Ile Phe Asp 
            180                 185                 190         


Gly Trp Ser Thr Gly Ile Phe Cys Asn Glu Leu Ser Glu Ile Tyr Asn 
        195                 200                 205             


Ala Leu Ile Ser Gly Arg Glu Tyr Asn Leu Pro Gln Leu Glu Val Gln 
    210                 215                 220                 


Tyr Ala Asp Tyr Val Val Trp Gln His Lys Lys Leu Asn Asn Glu Val 
225                 230                 235                 240 


Ile Glu Lys Gln Leu Thr Tyr Trp Arg Gln Lys Leu Thr Gly Asn Val 
                245                 250                 255     


Gln Val Ile Glu Leu Pro Thr Asp Arg Pro Arg Pro Ser Ile Lys Thr 
            260                 265                 270         


Val Arg Gly Gly Ala Leu Pro Phe Glu Leu Ser Pro Ala Leu Ser Lys 
        275                 280                 285             


Glu Ile Lys Ile Leu Thr Val Arg Lys Arg Cys Thr Leu Phe Met Thr 
    290                 295                 300                 


Leu Leu Ala Ala Phe Lys Thr Leu Leu Tyr Arg Tyr Thr Cys Gln Asp 
305                 310                 315                 320 


Asn Ile Thr Val Gly Thr Pro Ile Gly Asn Arg Ser Gln Leu Asp Cys 
                325                 330                 335     


Glu Lys Leu Met Gly Leu Phe Ile Asn Thr Leu Val Leu Cys Thr Lys 
            340                 345                 350         


Thr Gly Asp Asp Pro Ser Phe Ser Asp Leu Leu Glu Arg Val Arg Asn 
        355                 360                 365             


Val Thr Leu Glu Ala Tyr Glu Asn Gln Asp Ile Pro Phe Gln Lys Leu 
    370                 375                 380                 


Val Glu Glu Leu Lys Pro Glu Arg Asp Leu Ser Arg Asn Val Phe Tyr 
385                 390                 395                 400 


Gln Val Met Phe Asn Phe Ser Asp Met Ser Lys Val Cys Met Arg Leu 
                405                 410                 415     


Glu Gly Leu Glu Val Ser Pro Phe Glu Leu Gly Gly Ser Thr Ala Asn 
            420                 425                 430         


Val Asp Leu Gln Leu Tyr Val Trp Gln Glu Gly Glu Val Ile Lys Gly 
        435                 440                 445             


Tyr Phe Glu Tyr Asn Lys Asp Leu Phe Asp Glu Ser Thr Ile Lys Arg 
    450                 455                 460                 


Leu Ile Glu Gln Tyr Lys Val Leu Leu Gln Gly Val Val Asn Asp Pro 
465                 470                 475                 480 


Glu Arg His Leu Ser Glu Leu Pro Ile Leu Pro Leu Glu Glu Lys Asn 
                485                 490                 495     


Lys Val Leu Tyr Glu Trp Asn Asp Asn Asp Val Ala Tyr Pro His Ile 
            500                 505                 510         


Asn Gly Leu His Lys Phe Phe Glu Arg Gln Val Glu Lys Thr Pro Asp 
        515                 520                 525             


Ser Pro Ala Val Phe Phe Glu Asn Glu Tyr Cys Thr Tyr Gln Glu Leu 
    530                 535                 540                 


Asn Glu Arg Ala Asn Gln Leu Ala His Tyr Leu Ile Asn Ile Gly Ala 
545                 550                 555                 560 


Lys Lys Asn Thr Ala Ile Gly Leu Phe Leu Asp Arg Ser Ile Asp Met 
                565                 570                 575     


Ile Val Gly Met Phe Gly Ile Met Lys Ser Gly Ala Ala Tyr Val Pro 
            580                 585                 590         


Leu Asp Ile Lys Tyr Pro Ser Asp Arg Ile Ala Ala Ile Leu Lys Glu 
        595                 600                 605             


Ala Gly Ile Lys Ile Leu Ile Thr Gln Asp Asp Leu Leu Ser Asp Val 
    610                 615                 620                 


Pro Gln Met Glu Gly Leu Asn Val Ile Cys Ile Asp Arg Glu Gln Lys 
625                 630                 635                 640 


Lys Ile Cys Ser Phe Ser Lys Glu Asn Pro Ser Val Glu Val Ser Asn 
                645                 650                 655     


Asn Asp Leu Leu Tyr Ile Leu Phe Thr Ser Gly Thr Thr Gly Lys Pro 
            660                 665                 670         


Lys Gly Val Leu Val Glu His Arg Cys Tyr Ile Asn Tyr Ile Gln Gly 
        675                 680                 685             


Ile Ile Arg Lys Leu Glu Ile Asp Ser Pro Leu Asn Phe Ala Ile Val 
    690                 695                 700                 


Ser Ser Phe Ala Ala Asp Leu Gly Thr Thr Asn Ile Phe Ile Pro Leu 
705                 710                 715                 720 


Phe Thr Gly Gly Gln Leu His Ile Leu Ser Tyr Glu Arg Ala Thr Asp 
                725                 730                 735     


Pro Glu Lys Phe Leu Asp Tyr Phe Arg Lys His Lys Ile Asp Ala Met 
            740                 745                 750         


Lys Leu Val Pro Ser His Phe Glu Ala Leu Lys Thr Val Gln Asn Phe 
        755                 760                 765             


Glu Asp Ile Ile Pro Gly Lys Arg Leu Val Phe Ala Gly Glu Ala Cys 
    770                 775                 780                 


Ser Trp Glu Leu Ile Glu Glu Val Arg Arg Leu Asn Pro Ser Cys Met 
785                 790                 795                 800 


Ile Gln Asn His Tyr Gly Pro Thr Glu Thr Thr Val Ser Ala Leu Ala 
                805                 810                 815     


Tyr Leu Val Pro Asp Glu Leu Pro Gln His Ala Gly Ser Val Val Pro 
            820                 825                 830         


Ile Gly Arg Pro Leu Pro Asn Val Lys Ala Tyr Val Leu Asp Lys His 
        835                 840                 845             


Arg Gln Pro Val Pro Ile Gly Val Val Gly Glu Leu Tyr Ile Gly Gly 
    850                 855                 860                 


Ala Gly Val Ala Arg Gly Tyr Ile Asn Glu Pro Glu Met Thr Lys Gln 
865                 870                 875                 880 


Lys Phe Ile Pro Asn Pro Phe His Pro Gly Pro Ser Ser Tyr Met Tyr 
                885                 890                 895     


Arg Thr Gly Asp Leu Val Arg Tyr Leu Pro Asp Gly Asn Ile Glu Phe 
            900                 905                 910         


Leu Gly Arg Ile Asp Arg Gln Ile Lys Ile Arg Gly Tyr Arg Ile Asp 
        915                 920                 925             


Pro Glu Glu Ile Glu His Ala Ile Lys Glu His Ser Val Val Arg Asp 
    930                 935                 940                 


Ala Val Val Thr Val Arg Gly Asn Ser Glu Lys Ser Asn Lys Leu Val 
945                 950                 955                 960 


Ala Tyr Leu Val Leu Asp Lys Lys Ala Glu Gly Asn Leu Asp Ile Ser 
                965                 970                 975     


Glu Ile Arg Arg Tyr Leu Lys Lys Lys Leu Pro Glu Tyr Met Arg Pro 
            980                 985                 990         


Ser Ser Phe Thr Val Leu Asp Ser  Ile Pro Leu Asn Thr  Asn Gly Lys 
        995                 1000                 1005             


Val Asp  Tyr Lys Ser Leu Pro  Glu Pro Ser Glu Asp  Ile Ile Glu 
    1010                 1015                 1020             


Asp Asp  Asn Tyr Val Ala Pro  Arg Asn Glu Leu Glu  Glu Lys Ile 
    1025                 1030                 1035             


Ala Ser  Ile Trp Lys Glu Thr  Leu Glu Ile Ser Arg  Val Gly Ile 
    1040                 1045                 1050             


Asp Asp  Asn Phe Phe Asp Leu  Gly Gly Glu Ser Phe  Lys Ala Met 
    1055                 1060                 1065             


Ser Val  Val Arg Lys Ile Ser  Pro Ser Leu Ser Val  Ile Asp Leu 
    1070                 1075                 1080             


Phe Lys  Tyr Pro Thr Ile Arg  Glu Leu Ser Asp Tyr  Ile Ser Asn 
    1085                 1090                 1095             


Lys Gln  Lys Glu Glu Lys Arg  Glu Ile Leu His Glu  Leu Thr Lys 
    1100                 1105                 1110             


His Val  Ser Lys Glu Lys Lys  Gln Met Asn Leu Ile  Cys Ile Pro 
    1115                 1120                 1125             


Tyr Gly  Gly Gly Ser Ala Val  Ala Tyr Gln Pro Leu  Ala Asn Glu 
    1130                 1135                 1140             


Ile Pro  Glu Asn Trp Ser Leu  Tyr Ala Val Gln Ile  Pro Gly Arg 
    1145                 1150                 1155             


Asp Phe  Ser Arg Pro His Glu  Lys Pro Glu Ser Leu  Glu Lys Val 
    1160                 1165                 1170             


Ala Glu  Met Cys Ile Ser Glu  Ile Lys Glu Lys Val  Thr Gly Pro 
    1175                 1180                 1185             


Ile Val  Leu Tyr Gly Gln Cys  Val Gly Gly Ala Leu  Ala Ile Lys 
    1190                 1195                 1200             


Leu Ala  Tyr Met Met Glu Glu  Gln Gly Met Glu Leu  Val Gly Val 
    1205                 1210                 1215             


Ile Glu  Ala Gly Asn Phe Pro  Ser Pro Arg Leu Pro  Gly Lys Trp 
    1220                 1225                 1230             


Phe Glu  Leu Trp Ser Lys Ile  Phe Pro Arg Asp Arg  Trp Ile Ser 
    1235                 1240                 1245             


Asn Arg  Leu Tyr Lys Glu Ile  Leu Lys Ser Ile Gly  Ala Pro Ile 
    1250                 1255                 1260             


Gly Gly  Ser Asn Asn Glu Ala  Glu Gln Asp Phe Ile  Ile Arg Ser 
    1265                 1270                 1275             


Leu Arg  His Asp Ser Arg Glu  Ala Glu Asp Tyr Tyr  Thr Lys Met 
    1280                 1285                 1290             


Phe Ser  Thr Glu Asn Leu Lys  Lys Leu Lys Ala Pro  Ile Thr Cys 
    1295                 1300                 1305             


Val Val  Gly Glu Arg Asp Arg  Thr Thr Glu Phe Tyr  Gln Glu Arg 
    1310                 1315                 1320             


Tyr Lys  Glu Trp Glu His Phe  Ser Asn Cys Val Asn  Leu Arg Val 
    1325                 1330                 1335             


Ile Glu  Asn Ala Gly His Phe  Phe Gln Lys His Gln  Ala Asp Ile 
    1340                 1345                 1350             


Leu Ala  Gln Ile Ile Val Asp  Gln Val Glu Lys Trp  Lys Asn Ile 
    1355                 1360                 1365             


Arg Ser  Ser Glu Phe Val Glu  Glu Ala Leu Glu Glu  Thr Val Asp 
    1370                 1375                 1380             


Lys Lys  Lys Val Lys Thr Ser  Ile Phe Asp Lys Ala  Asn Val Lys 
    1385                 1390                 1395             


Pro Ser  Met Lys Leu Phe Leu  Phe Ile Ala Leu Gly  Gln Ile Val 
    1400                 1405                 1410             


Ser Met  Phe Gly Thr Ser Leu  Thr Gly Phe Ala Leu  Gly Tyr Trp 
    1415                 1420                 1425             


Ile Tyr  Lys Glu Thr Gly Ser  Val Ser Tyr Tyr Thr  Leu Ile Ser 
    1430                 1435                 1440             


Val Cys  Thr Leu Leu Pro Asn  Ile Leu Ile Ser Pro  Ile Ala Gly 
    1445                 1450                 1455             


Ala Val  Ala Asp Arg Trp Asp  Arg Arg Lys Ile Met  Ile Ile Ser 
    1460                 1465                 1470             


Asp Thr  Phe Ala Ala Met Gly  Thr Leu Ala Ile Ala  Leu Leu Leu 
    1475                 1480                 1485             


Trp Ser  Gly Arg Leu Glu Ile  Trp His Ile Tyr Ile  Ser Thr Thr 
    1490                 1495                 1500             


Ile Ser  Ser Ile Ala Gly Ala  Phe Gln Arg Pro Ala  Phe Leu Ala 
    1505                 1510                 1515             


Ala Ile  Ala Gln Ile Thr Pro  Lys Gln Tyr Leu Gly  Gln Ala Asn 
    1520                 1525                 1530             


Gly Ile  Ala Gln Met Gly Ser  Ala Ser Gly Ser Met  Leu Ala Pro 
    1535                 1540                 1545             


Ile Ile  Gly Gly Met Leu Ala  Ser Ser Ile Asn Leu  Tyr Gly Ile 
    1550                 1555                 1560             


Leu Leu  Ile Asp Phe Ile Ser  Phe Leu Phe Ser Val  Val Pro Leu 
    1565                 1570                 1575             


Leu Leu  Val Ala Phe Pro Asn  Tyr Met Phe Lys Lys  Arg Glu Glu 
    1580                 1585                 1590             


Pro Phe  Ile Glu Glu Ile Lys  Gly Gly Trp Asn Tyr  Ile Ile Lys 
    1595                 1600                 1605             


Arg Lys  Cys Leu Ile Ile Met  Ile Gly Phe Phe Ile  Val Thr Asn 
    1610                 1615                 1620             


Phe Phe  Met Ser Leu Ser Thr  Val Leu Val Thr Pro  Val Val Leu 
    1625                 1630                 1635             


Ala Phe  Ala Ser Val Glu Thr  Met Gly Ile Val Thr  Ser Ala Asn 
    1640                 1645                 1650             


Gly Phe  Gly Leu Ile Val Gly  Ser Ile Ile Met Ser  Leu Trp Gly 
    1655                 1660                 1665             


Gly Thr  Lys Arg Arg Ala Asp  Gly Met Ile Gly Tyr  Val Ile Leu 
    1670                 1675                 1680             


Ser Gly  Ile Cys Leu Ile Leu  Ile Gly Ile Arg Pro  Ser Val Val 
    1685                 1690                 1695             


Leu Ala  Thr Ile Gly Leu Phe  Gly Phe Gly Leu Ser  Ile Ala Phe 
    1700                 1705                 1710             


Ile Asp  Thr His Trp Gln Ile  Leu Ile Gln Ser Lys  Val Gly Leu 
    1715                 1720                 1725             


Glu Leu  Gln Ala Arg Val Phe  Ser Ile Asn Glu Met  Leu Ala Phe 
    1730                 1735                 1740             


Ile Met  Arg Pro Leu Ala Phe  Phe Leu Ala Gly Pro  Leu Ser Asp 
    1745                 1750                 1755             


Lys Val  Phe Glu Pro Phe Met  Ala Gly Glu Gly Asn  Leu Ala Thr 
    1760                 1765                 1770             


Lys Ile  Ser Met Ile Ile Gly  Ser Gly Glu Gly Arg  Gly Met Gly 
    1775                 1780                 1785             


Leu Ile  Leu Val Leu Ser Gly  Ile Ile Leu Thr Ile  Trp Gly Ile 
    1790                 1795                 1800             


Met Gly  Phe Asn Tyr Arg Pro  Leu Arg Phe Met Glu  Asp Val Leu 
    1805                 1810                 1815             


Pro Asp  Ala Ile Pro Asp Pro  Val Ile Leu Lys Asp  Lys Asn Lys 
    1820                 1825                 1830             


Ile Gln  Glu Leu Ala Asp Met  Gln Leu Leu Lys Thr  Ile Gln Asn 
    1835                 1840                 1845             


Asp Arg  Lys Arg Ala Lys Ile  
    1850                 1855 


<210>  2
<211>  1816
<212>  PRT
<213>  Herpetosiphon aurantiacus

<400>  2

Met Thr Glu Val Ala Arg Gln Leu Glu Asp Leu Ser Pro Glu Arg Arg 
1               5                   10                  15      


Ala Leu Leu Ala Gln Arg Leu Arg Gln Arg Gln Ala Ala Lys Pro Val 
            20                  25                  30          


Pro Ser Ile Pro Ala Leu Ala Arg Ile Gly Glu His Pro Ala Phe Glu 
        35                  40                  45              


Leu Ser Phe Ala Gln Gln Arg Leu Trp Phe Leu Ser Gln Trp Gln Pro 
    50                  55                  60                  


Glu Ser Ala Ala Tyr His Ile Pro Ala Thr Phe Ser Ile Ala Gly Glu 
65                  70                  75                  80  


Ile Asn Val Ser Val Leu Gln Thr Cys Leu Asp Lys Ile Ile Gln Arg 
                85                  90                  95      


His Glu Val Leu Arg Ser Thr Ile Glu Val Leu Asn Asp Gln Pro Met 
            100                 105                 110         


Gln Val Ile Gln Pro Phe Arg Ser Leu Asp Leu Glu Leu Val Asp Leu 
        115                 120                 125             


Arg Gly Leu Ser Asn Glu Gln Gln Ala Ser Gln Arg Gln Gln Gln Ile 
    130                 135                 140                 


Glu Arg His Ser Gln Gln Pro Phe Asp Leu Ser Lys Asp Leu Met Leu 
145                 150                 155                 160 


Arg Gly Leu Leu Leu His Thr Ala Ala Asp His Ala Glu Leu Val Leu 
                165                 170                 175     


Thr Ile His His Ile Ala Cys Asp Gly Trp Ser Ile Gly Val Leu Leu 
            180                 185                 190         


Arg Glu Leu Gly Gln Leu Tyr Glu Ala Gly Leu Arg Gly Glu Gln Leu 
        195                 200                 205             


Glu Leu Pro Ala Leu Pro Ile Gln Tyr Ala Asp Phe Ala Val Trp His 
    210                 215                 220                 


Lys Arg Tyr Val Leu Glu Gln Val Tyr Gln Gln His Leu Asn Phe Trp 
225                 230                 235                 240 


Gln Glu Gln Leu Ser Gly Thr Leu Pro Leu Leu Asn Leu Pro Thr Asp 
                245                 250                 255     


His Ala Arg Pro Ala Val Lys Arg Asp Leu Gly Ala Thr Val Glu Tyr 
            260                 265                 270         


His Leu Pro Trp Ser Leu Val Glu Ala Val Glu Arg Leu Ser Arg Gln 
        275                 280                 285             


Glu Arg Ala Thr Pro Phe Met Leu Phe Met Ala Ala Phe Gln Val Leu 
    290                 295                 300                 


Leu Tyr Arg Tyr Ser Gly Gln Ser Asp Leu Ile Ile Gly Thr Pro Ile 
305                 310                 315                 320 


Ala Asn Arg Thr Arg Arg Glu Ile Glu Asn Leu Ile Gly Phe Phe Val 
                325                 330                 335     


Asn Thr Leu Pro Ile Arg Val Asn Leu Ala Gly Ser Pro Ser Phe Arg 
            340                 345                 350         


Ser Leu Ile Ala Gln Val Arg Gln Thr Ser Leu Ala Ala Phe Glu His 
        355                 360                 365             


Gln Asp Met Pro Leu Glu His Leu Ile Asp Val Leu Lys Val Glu Arg 
    370                 375                 380                 


Ser Leu Ser His Asn Pro Leu Phe Gln Ala Leu Phe Val His Gln Thr 
385                 390                 395                 400 


Thr Ser Ile Gln Thr Val Asp Ser Gly Glu Phe Gly Leu Gln Phe Gly 
                405                 410                 415     


Gly Ala Ile Glu Thr Gly Ser Ala Lys Phe Asp Ile Asn Leu Asn Leu 
            420                 425                 430         


Ala Ala Asn Arg Ala Thr Phe Glu Tyr Asn Thr Asp Leu Phe Glu Arg 
        435                 440                 445             


Ser Thr Ile Glu Arg Met Ala Ser His Phe His Ser Leu Leu Glu Tyr 
    450                 455                 460                 


Ala Val Thr Asn Pro Asp Ala Ser Ile Glu His Leu Pro Leu Leu Ser 
465                 470                 475                 480 


Ser Ser Glu Arg Gln Gln Leu Leu Gln Thr Trp Asn Ser Thr Ser Ala 
                485                 490                 495     


Asn Tyr Pro Ala Val Asp Ser Ile Val Arg Leu Phe Glu Ala Gln Ala 
            500                 505                 510         


Ala Arg Val Pro Glu Arg Thr Ala Leu His Phe Glu Gly Gln Thr Leu 
        515                 520                 525             


Ser Tyr Ala Glu Leu Asn Gln Arg Ala Asn Gln Leu Ala His Ser Leu 
    530                 535                 540                 


Arg Gln Arg Gly Ile Gly Cys Asp Met Arg Val Gly Leu Phe Ile Asp 
545                 550                 555                 560 


Arg Ser Leu Asp Leu Leu Val Gly Ala Leu Gly Ile Leu Lys Ala Gly 
                565                 570                 575     


Ala Ala Tyr Val Pro Ile Asp Pro Ile Tyr Pro Gln Asp Arg Ile Ser 
            580                 585                 590         


Ala Met Leu Glu Asp Gly Ala Val Ser Leu Leu Leu Thr His Ala Glu 
        595                 600                 605             


Leu Ala Ala Glu Leu Pro Lys Leu Asp Leu Glu Val Leu Cys Leu Asp 
    610                 615                 620                 


Gln Ala Trp Pro Thr Ile Ala Gln Ala Pro Thr His Asn Leu Asn Leu 
625                 630                 635                 640 


Ala Leu Glu Pro Arg Ser Leu Met Tyr Val Leu Phe Thr Ser Gly Ser 
                645                 650                 655     


Thr Gly Arg Pro Lys Gly Val Ala Ile Glu His His Asn Tyr Val Asn 
            660                 665                 670         


Tyr Ile Gln Gly Leu Leu Gln Arg Ile Glu Ala Glu Asp Gly Trp Ser 
        675                 680                 685             


Tyr Ala Leu Val Ser Thr Phe Ala Ala Asp Leu Gly Thr Thr Asn Val 
    690                 695                 700                 


Tyr Gly Ala Leu Cys Ser Gly Gly Glu Leu His Ile Val Ala Tyr Glu 
705                 710                 715                 720 


Arg Ala Thr Asp Pro Glu Ala Phe Ala Ala Tyr Phe Arg Gln His Arg 
                725                 730                 735     


Ile Asp Val Met Lys Leu Val Pro Ser His Phe Glu Ala Met Arg Gly 
            740                 745                 750         


Leu Asn Asn Leu Ala Asp Val Ile Pro Lys Gln Arg Leu Ile Leu Ala 
        755                 760                 765             


Gly Glu Ala Ser Leu Trp Glu Gln Leu Ser Asp Ile Arg Gln Leu Gln 
    770                 775                 780                 


Pro Ser Val Gln Leu Gln Asn His Tyr Gly Pro Thr Glu Thr Thr Val 
785                 790                 795                 800 


Ser Met Leu Thr Tyr Pro Ile Pro Ser Gln Pro His Tyr Pro Ser Ser 
                805                 810                 815     


Thr Val Pro Leu Gly Arg Pro Leu Gly Asn Val Gln Ile Tyr Val Leu 
            820                 825                 830         


Asp Arg Arg Met Gln Pro Thr Pro Gln Gly Val Pro Gly Glu Leu Tyr 
        835                 840                 845             


Val Gly Gly Ala Gly Val Gly Arg Gly Tyr Ile Gly Arg Pro Asp Leu 
    850                 855                 860                 


Thr Ala Glu Arg Phe Val Pro Asn Pro Phe Ser Thr Glu Ala Gly Ala 
865                 870                 875                 880 


Arg Leu Tyr Arg Ser Gly Asp Leu Val Arg Tyr Gln Pro Asp Gly Ala 
                885                 890                 895     


Ile Glu Phe Leu Gly Arg Ile Asp Leu Gln Val Lys Ile Arg Gly Tyr 
            900                 905                 910         


Arg Val Glu Leu Ser Glu Ile Glu Thr Ala Ile Gln Ala Gln Ala Gln 
        915                 920                 925             


Val Ala Asn Ser Val Val Ile Leu Arg Glu Asp Thr Pro Gly Asp Lys 
    930                 935                 940                 


Arg Leu Val Ala Tyr Ile Val Pro Glu Ala Gly Gln Ser Leu Asn Ile 
945                 950                 955                 960 


Gly Ser Ile Arg Glu Ala Leu Arg Asn Ser Leu Pro Asp Tyr Met Val 
                965                 970                 975     


Pro Thr Ala Phe Val Glu Leu Asp Gly Leu Pro Leu Asn Pro Asn Gly 
            980                 985                 990         


Lys Ile Glu Arg Arg Ala Leu Pro  Ala Pro Ser Asn Glu  Arg Asn Leu 
        995                 1000                 1005             


Asp Ser  Tyr Val Ala Pro Gln  Thr Ala Thr Glu His  Glu Leu Ala 
    1010                 1015                 1020             


Gly Ile  Trp Ala Glu Val Leu  Gly Leu Asp Gln Val  Gly Ile Asp 
    1025                 1030                 1035             


Asp Asn  Phe Phe Asp Leu Gly  Gly Glu Ser Phe Lys  Ala Ile Arg 
    1040                 1045                 1050             


Val Val  Arg Lys Ile Gly Ser  His Ile Ser Val Met  Thr Leu Phe 
    1055                 1060                 1065             


Lys Tyr  Pro Thr Val Arg Glu  Leu Ala Ala His Leu  Ser Gly Ala 
    1070                 1075                 1080             


Ser Ser  Ala Glu Ser Gly Gly  Met Leu Tyr Glu Leu  Ser Lys Ala 
    1085                 1090                 1095             


Gln Ala  Lys Gln His Thr Thr  Ile Val Ala Ile Pro  Tyr Gly Gly 
    1100                 1105                 1110             


Gly Ser  Ala Ile Thr Tyr Gln  Pro Leu Ala Gln Ala  Met Pro Lys 
    1115                 1120                 1125             


Gly Tyr  Arg Leu Leu Ala Ala  Glu Leu Pro Gly His  Asp Phe Ser 
    1130                 1135                 1140             


Arg Pro  Asp Glu Pro Leu Gln  Ala Leu Glu Val Val  Ala Ser Gln 
    1145                 1150                 1155             


Leu Ala  Ser Glu Ile Gln Thr  Lys Thr Gln Gly Pro  Ile Val Leu 
    1160                 1165                 1170             


Tyr Gly  His Cys Val Gly Ser  Ala Met Thr Val Glu  Ile Gly Arg 
    1175                 1180                 1185             


Leu Leu  Glu Gln Ala Gly Arg  Asp Val Gln Gly Ile  Val Leu Gly 
    1190                 1195                 1200             


Gly Asn  Phe Pro Ala Ala Arg  Val Pro Gly Arg Phe  Phe Glu Trp 
    1205                 1210                 1215             


Leu Asn  Lys Leu Met Pro Ala  Asp Arg Trp Met Ser  Asp Arg Thr 
    1220                 1225                 1230             


Tyr Arg  Asp Phe Leu Arg Ala  Leu Gly Gly Phe Thr  Glu Ile Val 
    1235                 1240                 1245             


Asp Gln  Ala Glu Gln Thr Phe  Val Met Arg Ser Leu  Arg His Asp 
    1250                 1255                 1260             


Ala Arg  Glu Val Glu Arg Tyr  Phe Thr Gln Ala Phe  Ala Gln Lys 
    1265                 1270                 1275             


Gln Ser  Gln Gln Leu Lys Ala  Pro Ile Ala Cys Ile  Ile Gly Glu 
    1280                 1285                 1290             


Met Asp  Arg Ala Thr Glu Tyr  Tyr Gln Glu Arg Tyr  Arg Glu Trp 
    1295                 1300                 1305             


Glu Tyr  Phe Ser Asn Asn Val  Thr Leu His Val Ile  Pro His Ala 
    1310                 1315                 1320             


Gly His  Tyr Phe Leu Lys His  Gln Ala Ser Glu Leu  Gly Gln Ile 
    1325                 1330                 1335             


Ile Glu  Gln Gln Thr Glu Gln  Trp Gln Gln Pro Arg  Pro Ile Gln 
    1340                 1345                 1350             


Pro Thr  Ala Ala Lys Ser Lys  Ser His Lys Thr Ser  Met Pro Ser 
    1355                 1360                 1365             


Leu Arg  Ile Phe Phe Met Val  Ala Leu Gly Gln Leu  Val Ser Met 
    1370                 1375                 1380             


Leu Gly  Ser Ser Leu Ser Ser  Phe Ala Leu Gly Ile  Trp Ile Tyr 
    1385                 1390                 1395             


Gln Arg  Thr Gly Thr Val Ser  Asp Phe Ala Phe Thr  Ala Ile Ala 
    1400                 1405                 1410             


Ser Met  Leu Pro Ser Leu Leu  Val Ser Pro Leu Ala  Gly Ala Ile 
    1415                 1420                 1425             


Ala Asp  Arg Trp Asp Arg Arg  Trp Ile Met Ile Ile  Ala Asp Thr 
    1430                 1435                 1440             


Ile Ser  Ala Leu Ser Thr Ile  Val Ile Ala Met Leu  Leu Trp Ala 
    1445                 1450                 1455             


Asn Lys  Leu Glu Val Trp His  Ile Tyr Leu Thr Ala  Ala Ile Ser 
    1460                 1465                 1470             


Ser Ile  Ala Gly Thr Phe Gln  Arg Pro Ala Tyr Ala  Ala Ala Met 
    1475                 1480                 1485             


Thr Gln  Leu Val Pro Lys Gln  Tyr Leu Gly His Ala  Asn Gly Val 
    1490                 1495                 1500             


Ile Gln  Leu Gly Ser Ala Thr  Gly Gly Leu Ile Ala  Pro Phe Ile 
    1505                 1510                 1515             


Ala Gly  Gly Met Val Ala Phe  Phe Gly Leu Gly Gly  Val Phe Leu 
    1520                 1525                 1530             


Leu Asp  Phe Ile Ser Phe Ser  Leu Gly Ile Gly Val  Leu Phe Leu 
    1535                 1540                 1545             


Val Arg  Phe Pro Asn Thr Leu  Tyr His Lys Arg Glu  Glu Pro Leu 
    1550                 1555                 1560             


Leu Arg  Glu Ile Val Arg Gly  Trp Glu Tyr Ile Ile  Lys Arg Pro 
    1565                 1570                 1575             


Ser Leu  Val Ala Met Val Leu  Phe Phe Ala Leu Gly  Asn Ile Trp 
    1580                 1585                 1590             


Phe Gly  Ile Ala Ser Ile Ser  Met Ser Pro Leu Val  Leu Ser Phe 
    1595                 1600                 1605             


Gly Gly  Pro Ala Glu Leu Gly  Ile Val Ser Ala Ala  Cys Ala Leu 
    1610                 1615                 1620             


Gly Gly  Phe Leu Gly Gly Leu  Phe Met Ser Leu Trp  Gly Gly Leu 
    1625                 1630                 1635             


Gln Arg  Arg Ala Glu Gly Met  Val Gly Phe Val Ile  Leu Glu Gly 
    1640                 1645                 1650             


Phe Phe  Ile Ala Leu Ala Gly  Leu Arg Pro Ser Val  Trp Leu Val 
    1655                 1660                 1665             


Ala Leu  Ala Met Phe Gly Met  Trp Phe Ala Ile Ser  Leu Val Asn 
    1670                 1675                 1680             


Ala His  Trp Gln Val Leu Ile  Gln Thr Lys Val Gly  Leu Glu Leu 
    1685                 1690                 1695             


Gln Gly  Arg Val Gln Ala Thr  Asn Gln Met Leu Ala  Met Leu Ser 
    1700                 1705                 1710             


Ile Pro  Leu Gly Tyr Trp Leu  Ala Gly Pro Leu Ala  Asp Asn Leu 
    1715                 1720                 1725             


Phe Gly  Pro Leu Leu Glu Pro  Asn Gly Ala Leu Ser  Ser Ser Leu 
    1730                 1735                 1740             


Gly Trp  Leu Phe Gly Val Gly  Pro Asp Arg Gly Ile  Gly Leu Leu 
    1745                 1750                 1755             


Met Val  Val Val Gly Leu Gly  Ala Ala Ile Trp Ala  Leu Ile Gly 
    1760                 1765                 1770             


Phe Asn  Tyr Arg Pro Leu Arg  Tyr Met Glu Asp Ala  Leu Pro Asp 
    1775                 1780                 1785             


Ala Ile  Pro Asp Ala Glu Ile  Ala Ser Asp Arg Asp  Thr Ile Gln 
    1790                 1795                 1800             


Ala Gln  Ala Asp Gly Ile Ile  Ala Val Thr Ala Lys  Gly 
    1805                 1810                 1815     


<210>  3
<211>  2720
<212>  PRT
<213>  Streptosporangium roseum

<400>  3

Met Thr Glu Val Arg Gln Asp Arg Ile Ala Glu Met Val Arg Ser Arg 
1               5                   10                  15      


Phe Ala Ala Ala Arg Val Ala Ala Glu Thr Pro Gly Ala Ala Val Ile 
            20                  25                  30          


Pro Ala Leu Ser Thr Leu Asp Met Pro Leu Ser Pro Ala Gln Glu Arg 
        35                  40                  45              


Leu Trp Phe Leu Ala Gln Leu Glu Gln Asp Thr Pro Ala Tyr Asn Val 
    50                  55                  60                  


Pro Arg Ala Leu Arg Leu Ser Gly Pro Val Asp Val Ala Ala Leu Thr 
65                  70                  75                  80  


Ala Ala Val Ser Glu Leu Ala Asp Arg His Trp Ile Leu Arg Gly Val 
                85                  90                  95      


Ile Asp Gly Ala Arg Val Arg Pro Ala Asp Gly Val Pro Val Ser Val 
            100                 105                 110         


Val Asp Val Asp Pro Ala Ala Leu Glu Arg Glu Leu Ala Glu His Ala 
        115                 120                 125             


Trp Arg Pro Phe Arg Leu Asp Ala Glu Pro Pro Met Arg Ala Ala Val 
    130                 135                 140                 


Phe Arg Leu Gly Glu Asp Glu Tyr Val Leu Ala Leu Thr Leu His His 
145                 150                 155                 160 


Ile Ala Thr Asp Ala Trp Ser Glu Gln Leu Leu Leu Arg Asp Leu Ser 
                165                 170                 175     


Ala Leu Tyr Ala Ala Arg Leu Gly Leu Ala Pro Gln Pro Glu Pro Pro 
            180                 185                 190         


Ala Leu Gln Tyr Ala Asp Val Ala Ala Trp Glu Ala Glu Gln Pro Glu 
        195                 200                 205             


Val Asp Leu Asp Trp Trp Thr Gln Arg Leu Ala Gly Leu Pro Pro Val 
    210                 215                 220                 


Leu Asp Leu Pro Ile Ala Gly Pro Arg Pro Ala Val Pro Thr Trp Arg 
225                 230                 235                 240 


Gly Ala Ala Val Gly Phe Glu Val Pro Glu Ser Leu Ser Ser Lys Val 
                245                 250                 255     


Arg Ala Val Ala Gly Met Thr Pro Phe Met Val Phe Leu Ala Gly Leu 
            260                 265                 270         


Gln Ala Leu Leu Ser Arg Leu Ser Gly Ser Asp Asp Ile Ala Val Gly 
        275                 280                 285             


Val Pro His Ala Gly Arg His His Leu Asp Ala Glu Arg Val Val Gly 
    290                 295                 300                 


Cys Phe Ile Asn Thr Leu Ala Val Arg Thr Asp Thr Ser Gly Asp Pro 
305                 310                 315                 320 


Thr Gly Ala Glu Leu Leu Ser Arg Ala Arg Thr Ala Ala Leu Asp Ala 
                325                 330                 335     


Phe Thr His Ala Arg Thr Pro Phe Glu Arg Ile Val Glu Arg Leu Gln 
            340                 345                 350         


Pro Glu Arg Asn Leu Ser Val Thr Pro Leu Phe Gln Val Met Leu Asn 
        355                 360                 365             


Val Tyr Asp Ala Ala Ala Pro Val Ser Leu Ala Gly Val Glu Val Arg 
    370                 375                 380                 


Ala Glu Pro Leu Pro Val Pro Thr Ala Lys Phe Asp Leu Asn Leu Thr 
385                 390                 395                 400 


Leu Gly Asp Glu Gly Asp Arg Phe Ala Gly Glu Leu Arg Tyr Arg Ala 
                405                 410                 415     


Asp Leu Phe Glu Glu Ser Thr Val Arg Arg Leu Val Glu Trp Tyr Leu 
            420                 425                 430         


Ala Leu Leu Glu Gly Met Leu Thr Asp Pro Asp Ala Pro Val Arg Leu 
        435                 440                 445             


Pro Ala Gly Ala Asp Leu Arg Gly Pro Ala Gly Asp Leu Pro Thr Asp 
    450                 455                 460                 


Val Pro Leu His Ala Leu Val Glu Arg Met Ala Asp Ala Gly Pro Asp 
465                 470                 475                 480 


Val Thr Ala Val Ala Ser Leu Ser Tyr Ala Glu Leu Asp Arg Arg Ala 
                485                 490                 495     


Asn Gln Val Ala His Trp Leu Leu Ala Arg Gly Val Gly Pro Gln Glu 
            500                 505                 510         


Pro Val Gly Val Leu Leu Glu Arg Arg Pro Glu Leu Val Val Ala Leu 
        515                 520                 525             


Leu Gly Val Leu Lys Ala Gly Ala Ala Tyr Leu Pro Leu Asp Pro Val 
    530                 535                 540                 


Tyr Pro Ala Arg Arg Thr Glu Ala Ile Leu Ala Asp Ala Gly Ala Arg 
545                 550                 555                 560 


Ile Val Leu Thr Glu Ser Glu Ile Ala Ala Ala Ala Asp Gly Pro Gly 
                565                 570                 575     


His Arg Pro Asp Val Ala Val Arg Pro Asp His Leu Ala Tyr Val Ile 
            580                 585                 590         


Tyr Thr Ser Gly Ser Thr Gly Glu Pro Lys Gly Val Ala Val Glu His 
        595                 600                 605             


Arg Gln Ile Thr His Tyr Leu Gly Ala Val Ala Glu Arg Ile Pro Ala 
    610                 615                 620                 


Gly Val Thr Ser Phe Ala Leu Val Ser Thr Ala Ala Ala Asp Leu Gly 
625                 630                 635                 640 


Leu Thr Asn Val Leu Cys Ala Leu Thr Ser Gly Ala Thr Leu His Leu 
                645                 650                 655     


Ile Asp His Glu Thr Ala Thr Asp Pro Val Ala Tyr Ala Ala Tyr Met 
            660                 665                 670         


Ala Ala His Pro Val Asp Val Ile Lys Met Val Pro Ser Gln Leu Glu 
        675                 680                 685             


Leu Leu Gly Val Asp Ala Leu Pro Arg Lys Leu Leu Ile Leu Ala Gly 
    690                 695                 700                 


Glu Ala Val Pro Ser Asp Leu Val Glu Arg Val Arg Ala Ala Arg Pro 
705                 710                 715                 720 


Ala Leu Ala Val Gln Ile His Tyr Gly Pro Thr Glu Thr Thr Val Ser 
                725                 730                 735     


Val Leu Ala Cys Asp Ala Ala Glu Val Ala Pro Gly Val Ala Pro Leu 
            740                 745                 750         


Gly Arg Pro Leu Ala Asp Val Glu Cys Arg Val Val Asp Ser Ala Gly 
        755                 760                 765             


Arg Pro Leu Pro Ala Gly Val Pro Gly Glu Leu Trp Ile Gly Gly Pro 
    770                 775                 780                 


Ser Leu Ala Arg Gly Tyr Leu Gly Arg Pro Asp Leu Thr Ala Gln Arg 
785                 790                 795                 800 


Phe Val Asp Gly Trp Tyr Arg Thr Gly Asp Arg Val Arg Val Asn Pro 
                805                 810                 815     


Ala Gly Leu Val Glu Phe Leu Gly Arg Ile Asp Asp Gln Val Lys Val 
            820                 825                 830         


Arg Gly Phe Arg Val Glu Leu Gly Glu Val Ala Ala Ala Leu Arg Ala 
        835                 840                 845             


Leu Pro Gln Val Ala Glu Ala Phe Val Gln Pro Val Gly Ala Gly Ala 
    850                 855                 860                 


Gln Arg Arg Leu Ala Ala Trp Val Thr Pro Ser Thr Val Asp Thr Ala 
865                 870                 875                 880 


Gln Val Arg Ala Thr Leu Arg Glu Arg Leu Pro Asp Tyr Met Val Pro 
                885                 890                 895     


Pro Ala Ile Ala Ala Leu Glu Ala Leu Pro Leu Thr Pro Asn Gly Lys 
            900                 905                 910         


Val Asp Arg Ala Ala Leu Pro Val Pro Glu Ala Gly Ser Ala Val Arg 
        915                 920                 925             


Val Pro Leu Gly Thr Pro Gln Glu His Leu Val Ala Glu Val Trp Ala 
    930                 935                 940                 


Glu Val Leu Asp Leu Pro Gln Val Trp Ala Asp Asp Asp Phe Phe Ala 
945                 950                 955                 960 


Leu Gly Gly His Ser Phe Ala Ala Thr Arg Ala Val Gly Arg Leu Arg 
                965                 970                 975     


Glu Arg Leu Gly Ala Pro Val Pro Val Arg Leu Leu Phe Glu His Pro 
            980                 985                 990         


Val Leu Ala Asp Leu Ala Ala Ala  Leu Pro Arg Pro Val  Gln Val Val 
        995                 1000                 1005             


Arg Ala  Arg Arg Glu Arg Ala  Asp Gly Pro Ala Ala  Leu Ser Gly 
    1010                 1015                 1020             


Val Gln  Ala Arg Leu Trp Phe  Leu Ala Gln Leu Glu  Pro Glu Ser 
    1025                 1030                 1035             


Thr Ala  Tyr Asn Val Pro Val  Ala Leu Arg Leu His  Gly Pro Leu 
    1040                 1045                 1050             


Gln Val  Glu Ala Leu Leu Asp  Ala Val Arg Asp Leu  Ala Glu Arg 
    1055                 1060                 1065             


His His  Val Leu Arg Ser Val  Ile Asp Asp Ser Gly  Ala Glu Pro 
    1070                 1075                 1080             


Val Leu  Val Val Arg Pro Ala  Gly Glu Val Pro Val  Ser Thr Ala 
    1085                 1090                 1095             


Asp Ile  Asp Arg Ser Arg Val  Glu Asp Ala Val Ala  Ala Gln Leu 
    1100                 1105                 1110             


Ala Thr  Pro Phe Ala Leu Asp  Arg Glu Pro Pro Met  Arg Ala Val 
    1115                 1120                 1125             


Leu Phe  Ala Val Gly Asp Arg  Glu His Val Leu Ser  Leu Thr Phe 
    1130                 1135                 1140             


His His  Ile Ala Thr Asp Ala  Trp Thr Arg Gly Leu  Leu Leu Ser 
    1145                 1150                 1155             


Glu Leu  Ser Ala Leu Tyr Ala  Ala Arg Ile Gly Leu  Arg Pro Thr 
    1160                 1165                 1170             


Pro Glu  Pro Pro Pro Ala Gln  Tyr Ala Glu Val Ala  Pro Val Pro 
    1175                 1180                 1185             


Asp Leu  Ala Asp Leu Asp Trp  Trp Ala Glu Gln Leu  Arg Gly Leu 
    1190                 1195                 1200             


Pro Pro  Val Leu Asp Leu Pro  Thr Asp Arg Pro Arg  Pro Ala Val 
    1205                 1210                 1215             


Ala Asp  Pro Gly Gly Ala Ser  Val Asp Leu Glu Leu  Pro Ala Glu 
    1220                 1225                 1230             


Leu Ser  Glu Arg Val Arg Ala  Val Ala Thr Ala Tyr  Arg Ala Thr 
    1235                 1240                 1245             


Pro Phe  Ile Val Leu Leu Ala  Gly Leu Gln Ala Leu  Leu Ala Arg 
    1250                 1255                 1260             


Leu Ser  Ala Gly Thr Asp Ile  Ala Val Gly Val Pro  Val Ala Gly 
    1265                 1270                 1275             


Arg Asp  His Pro Asp Ser Glu  Gly Val Ile Gly Cys  Phe Leu Asn 
    1280                 1285                 1290             


Thr Val  Val Val Arg Thr Asp  Val Gly Gly Glu Pro  Thr Gly His 
    1295                 1300                 1305             


Glu Leu  Leu Ala Arg Val Arg  Glu Thr Ala Leu Gly  Ala Phe Ala 
    1310                 1315                 1320             


His Ala  Ser Ala Pro Phe Asp  Arg Val Val Asp Arg  Leu Arg Pro 
    1325                 1330                 1335             


Glu Arg  Asn Leu Ala Ala Thr  Pro Leu Phe Gln Val  Met Leu Asn 
    1340                 1345                 1350             


Tyr Phe  Pro Asp Thr Gly Arg  Pro Glu Leu Pro Gly  Leu Glu Ala 
    1355                 1360                 1365             


Ala Glu  Ile His Leu Pro Glu  Gln Thr Ala Lys Phe  Asp Leu Asn 
    1370                 1375                 1380             


Trp His  Val Ile Asp Ser Gly  Pro Gly Arg Pro Leu  Arg Gly Gly 
    1385                 1390                 1395             


Leu Gly  Tyr Arg Thr Asp Leu  Phe Asp Gly Ala Thr  Ala Ala Arg 
    1400                 1405                 1410             


Phe Thr  Arg Trp Tyr Leu Ala  Leu Leu Asp Gly Met  Leu Ser Asp 
    1415                 1420                 1425             


Leu Glu  Ala Pro Val Gly Ala  Gln Pro Leu Glu Pro  Val Thr Gly 
    1430                 1435                 1440             


Pro Ile  Leu Ala Gly Glu Pro  Leu Pro Ala Val Ala  Asp Thr Pro 
    1445                 1450                 1455             


Val His  Arg Leu Ile Glu Arg  Trp Val Asp Thr Thr  Pro Asp Ala 
    1460                 1465                 1470             


Pro Ala  Val Val Gly Ala Asp  Arg Gly Leu Thr Tyr  Ala Glu Leu 
    1475                 1480                 1485             


Glu Thr  Ala Ala Asn Arg Ile  Ala His Trp Leu Leu  Ala Ala Gly 
    1490                 1495                 1500             


Val Gly  Ala Asp Glu Pro Val  Gly Val Leu Leu Glu  Pro Gly Ala 
    1505                 1510                 1515             


Asp Leu  Ala Cys Ala Leu Phe  Gly Ile Gln Lys Ser  Gly Gly Gly 
    1520                 1525                 1530             


Tyr Leu  Pro Met Asp Pro Ala  Tyr Pro Ala Ala Arg  Ile Ala Thr 
    1535                 1540                 1545             


Met Leu  Asp Ala Ala Gly Val  Arg Ala Val Val Thr  Thr Ala Glu 
    1550                 1555                 1560             


Phe Ala  Gly Leu Ile Gly Pro  Asp Arg Trp Val Leu  Ala Leu Asp 
    1565                 1570                 1575             


Arg Leu  Pro Ser Leu Pro Arg  Thr Arg Pro Glu Val  Asp Val Arg 
    1580                 1585                 1590             


Pro Glu  His Leu His His Val  Ile Phe Thr Ser Gly  Ser Thr Gly 
    1595                 1600                 1605             


Thr Pro  Lys Ala Val Ala Ala  Glu His Arg Gly Val  Met Ser Tyr 
    1610                 1615                 1620             


Leu Asn  Gly Met Leu Pro Arg  Ile Gly Val Pro Gly  Gly Ser Tyr 
    1625                 1630                 1635             


Ala Val  Val Ser Thr Pro Ala  Ala Asp Phe Gly Leu  Thr Cys Val 
    1640                 1645                 1650             


Phe Gly  Ala Leu Thr Thr Gly  Gly Thr Val His Leu  Val Pro Arg 
    1655                 1660                 1665             


Glu Thr  Ala Met Asp Pro Ala  Ala Phe Ala Gly Tyr  Leu Ser Ala 
    1670                 1675                 1680             


His His  Val Asp Val Val Lys  Cys Val Pro Ser His  Leu Glu Leu 
    1685                 1690                 1695             


Leu Ala  Ser Gly Gly Asp Leu  Ala Ala Val Leu Pro  Asp Arg Leu 
    1700                 1705                 1710             


Leu Ile  Leu Ala Gly Glu Ala  Cys Pro Trp Asp Leu  Val Glu Arg 
    1715                 1720                 1725             


Ala Arg  Ala Ala Arg Pro Gly  Leu Arg Ile Gln Ser  His Tyr Gly 
    1730                 1735                 1740             


His Thr  Glu Ser Thr Met Ile  Cys Leu Val Cys Asp  Thr Glu Glu 
    1745                 1750                 1755             


Ile Ala  Ala Glu His Arg Thr  Gly Ile Val Pro Leu  Gly Arg Pro 
    1760                 1765                 1770             


Leu Pro  Gly Val Tyr Gly His  Leu Val Asp Ala Ser  Arg Arg Pro 
    1775                 1780                 1785             


Val Pro  Ala Gly Val Pro Gly  Glu Leu Val Val Gly  Gly Pro Gly 
    1790                 1795                 1800             


Val Thr  Arg Gly Tyr Ile Gly  Leu Pro Glu Leu Thr  Ala Glu Arg 
    1805                 1810                 1815             


Phe Val  Pro Asp Pro Leu Thr  Gly Gln Gly Arg Cys  Tyr Arg Ser 
    1820                 1825                 1830             


Gly Asp  Leu Leu Arg Val Thr  Ala Asp Gly Arg Val  Glu Phe Arg 
    1835                 1840                 1845             


Gly Arg  Val Asp Asp Gln Val  Lys Val Arg Gly Tyr  Arg Val Glu 
    1850                 1855                 1860             


Leu Gly  Glu Val Thr Thr Ala  Leu Arg Ala Leu Pro  Gln Ile Ala 
    1865                 1870                 1875             


Asp Ala  Val Val Leu Pro Val  Gly Glu Gly Lys Ala  Arg Gln Leu 
    1880                 1885                 1890             


Ala Ala  Trp Val Thr Pro Ser  Thr Val Asp Thr Ser  Ala Ile Arg 
    1895                 1900                 1905             


Ser Ala  Leu Arg Glu Arg Leu  Pro Asp Tyr Met Val  Pro Ala Gln 
    1910                 1915                 1920             


Phe Val  Val Leu Asp Arg Ile  Pro Leu Asn Pro Asn  Gly Lys Val 
    1925                 1930                 1935             


Asp Arg  Ala Ala Leu Pro Glu  Pro Arg Pro Glu Thr  Ala Glu Phe 
    1940                 1945                 1950             


Val Pro  Pro Ser Thr Ala Gly  Glu Glu Leu Val Ala  Arg Ala Trp 
    1955                 1960                 1965             


Ala Gln  Val Leu Gly Val Ala  Arg Val Gly Ala His  Asp Asp Phe 
    1970                 1975                 1980             


Phe Ala  Leu Gly Gly Asp Ser  Phe Ala Ala Val Arg  Ala Val Lys 
    1985                 1990                 1995             


Glu Ile  Gly Cys Gly Leu Arg  Val Ile Asp Leu Phe  Thr Arg Pro 
    2000                 2005                 2010             


Thr Val  Ala Glu Leu Ala Ala  Phe Leu Asp Arg Arg  Asp Gly Gly 
    2015                 2020                 2025             


Gly Leu  Leu His Arg Leu Gly  Gly Gly Arg Thr Ser  Glu Phe Thr 
    2030                 2035                 2040             


Leu Val  Cys Leu Pro Tyr Gly  Gly Gly Ser Ala Ala  Val Tyr Gln 
    2045                 2050                 2055             


Pro Leu  Ala Trp Ala Leu Gly  Glu Arg Val Glu Val  Leu Ser Ala 
    2060                 2065                 2070             


Glu Leu  Pro Gly His Asp Pro  Ala Arg Pro Asp Glu  Leu Pro Leu 
    2075                 2080                 2085             


Pro Leu  Glu Glu Leu Val Glu  Ala Leu Ser Ala Glu  Val Ala Thr 
    2090                 2095                 2100             


Thr Ala  Ser Gly Pro Ile Ala  Ile Tyr Gly His Cys  Val Gly Ser 
    2105                 2110                 2115             


Ala Pro  Ala Val Ala Leu Ala  Arg Arg Leu Glu Ala  Asp Gly Ile 
    2120                 2125                 2130             


Pro Val  Leu Gly Val Ile Ala  Ala Gly Ser Phe Pro  Thr Ala Gln 
    2135                 2140                 2145             


Leu Pro  Gly Leu Ala Arg Arg  Ile Phe Arg Ser Asp  Arg Trp Val 
    2150                 2155                 2160             


Ser Asp  Arg Met Phe Gln Asp  Ala Leu Arg Ala Thr  Gly Gly Leu 
    2165                 2170                 2175             


Leu Asp  Asp Met Asp Glu Ala  Ala Lys Gln Val Ala  Val Arg Ala 
    2180                 2185                 2190             


Met Arg  His Asp Ala Asp Gln  Ala Gln Glu Trp Phe  Ser Arg Glu 
    2195                 2200                 2205             


Leu Thr  Gly Gly Gly Pro Pro  Leu Arg Ala Pro Ile  Leu Cys Val 
    2210                 2215                 2220             


Val Gly  Glu Arg Asp Arg Ala  Thr Glu Leu His Gln  Glu Arg Tyr 
    2225                 2230                 2235             


Ala Glu  Trp Thr Ala Phe Ala  Pro Arg Val Glu Leu  Ala Val Leu 
    2240                 2245                 2250             


Pro His  Ala Gly His Tyr Phe  Leu Arg His Gln Ala  Glu Pro Leu 
    2255                 2260                 2265             


Ala Ala  Leu Val Ile Glu His  Leu Arg Ser Trp Ala  Ala Gly Arg 
    2270                 2275                 2280             


Leu Pro  Asp Pro Val Arg Pro  Pro Asp Arg Thr Gly  Leu Arg Pro 
    2285                 2290                 2295             


Phe Tyr  Thr Val Ala Gly Gly  Gln Phe Val Ser Val  Val Gly Thr 
    2300                 2305                 2310             


Ala Leu  Ser Ser Phe Ala Leu  Gly Val Trp Ala Tyr  Gln Asp Ser 
    2315                 2320                 2325             


Gly Arg  Ile Leu Asp Leu Ala  Leu Ile Val Met Leu  Ser Gln Ile 
    2330                 2335                 2340             


Pro Ala  Val Leu Leu Thr Pro  Leu Gly Gly Ala Leu  Ala Asp Arg 
    2345                 2350                 2355             


Val Asp  Arg Arg Arg Ile Met  Leu Val Ser Asp Ala  Val Ser Gly 
    2360                 2365                 2370             


Leu Ala  Met Ala Ala Leu Val  Leu Leu Leu Val Thr  Asp Arg Leu 
    2375                 2380                 2385             


Ala Leu  Trp Asn Val Cys Leu  Ile Val Gly Val Thr  Ser Leu Ala 
    2390                 2395                 2400             


Thr Ala  Phe Gln Gln Pro Ala  Tyr Leu Ala Ala Ile  Ala Gln Leu 
    2405                 2410                 2415             


Val Pro  Lys Pro Tyr Leu Pro  Gln Ala Asn Ala Val  Ala Asn Leu 
    2420                 2425                 2430             


Gly Phe  Gly Ile Gly Asn Val  Val Ala Pro Leu Ala  Gly Gly Ala 
    2435                 2440                 2445             


Leu Ile  Gly Met Phe Gly Leu  Ser Ala Val Val Ala  Ile Asp Val 
    2450                 2455                 2460             


Ala Ser  Phe Gly Val Gly Val  Ala Thr Leu Leu Ala  Val Arg Phe 
    2465                 2470                 2475             


Pro Asp  Arg Leu Phe His Arg  Gln Glu Glu Thr Phe  Arg Ala Ala 
    2480                 2485                 2490             


Leu Thr  Gly Gly Trp Leu Phe  Leu Arg Arg Arg Arg  Pro Leu Leu 
    2495                 2500                 2505             


Val Met  Ala Val Tyr Phe Ala  Val Val Asn Phe Cys  Thr Ala Leu 
    2510                 2515                 2520             


Met Trp  Val Leu Ile Thr Pro  Val Val Leu Ala Leu  Gly Ser Ser 
    2525                 2530                 2535             


Ala Ala  Leu Gly Ala Val Thr  Ala Val Gly Gly Leu  Gly Ala Ala 
    2540                 2545                 2550             


Val Gly  Thr Ala Val Val Leu  Val Trp Gly Gly Thr  Arg Arg Arg 
    2555                 2560                 2565             


Ala Thr  Gly Met Val Gly Phe  Val Ile Gly Ser Gly  Ile Gly Val 
    2570                 2575                 2580             


Val Leu  Met Gly Val Trp Pro  Ala Leu Trp Leu Val  Ala Ala Gly 
    2585                 2590                 2595             


Leu Phe  Leu Arg Leu Ala Cys  Met Ser Ile Gly Asn  Ala His Trp 
    2600                 2605                 2610             


Leu Ser  Ile Ile Gln Val Lys  Val Gly Pro Glu Leu  Gln Gly Arg 
    2615                 2620                 2625             


Val Leu  Ala Val Asn Val Met  Leu Ala Thr Ala Met  Gln Pro Leu 
    2630                 2635                 2640             


Gly Phe  Leu Ala Ala Gly Pro  Leu Ala Asp Trp Ala  Gln Ser Tyr 
    2645                 2650                 2655             


Thr Ser  Gly Pro Gly Arg Gly  Ala Ala Ala Val Leu  Leu Val Ser 
    2660                 2665                 2670             


Gly Val  Phe Leu Val Val Trp  Gly Val Ile Gly Leu  Arg Tyr Arg 
    2675                 2680                 2685             


Pro Leu  His His Leu Glu Asp  Leu Val Pro Asp Ala  Ala Pro Pro 
    2690                 2695                 2700             


Pro Glu  Ala Glu Ala Asp Leu  Asp Ala Ile Gln Ala  Lys Val Leu 
    2705                 2710                 2715             


Ser Gly  
    2720 


<210>  4
<211>  1769
<212>  PRT
<213>  Catenulispora acidiphila

<400>  4

Met Pro Pro Leu Ser Phe Ala Gln Glu Arg Leu Trp Phe Met Glu Gln 
1               5                   10                  15      


Leu Ala Pro Gly Ser Ala Ala His Thr Val Pro Val Ala Leu Arg Leu 
            20                  25                  30          


Arg Gly Ala Leu Asp Pro Asp Ala Phe Gly Arg Ala Leu Arg Asp Leu 
        35                  40                  45              


Ala Gly Arg His Glu Thr Leu Arg Met Ser Tyr Pro Ala Asp Thr Asp 
    50                  55                  60                  


Asp Arg Pro Gly Ile His Val Ala Ala Ala Gly Glu Val Pro Leu Arg 
65                  70                  75                  80  


Ile Ser Asp Ala Asp Ser Leu Asp Ala Ala Gln Asp Val Val Gly Ala 
                85                  90                  95      


Met Ile Ala Glu Pro Phe Asp Ile Val Arg Gly Pro Val Ala Arg Ala 
            100                 105                 110         


Leu Leu Val Arg Leu Ala Asp Asp Asp His Val Leu Ala Leu Ala Val 
        115                 120                 125             


His His Ile Ala Cys Asp Gly Trp Ser Val Asp Val Leu Leu Thr Asp 
    130                 135                 140                 


Leu Phe Ala Leu Tyr Glu Ala Arg Leu Ala Gly Ala Pro Ser Thr Leu 
145                 150                 155                 160 


Pro Glu Pro Ala Ile Gly Tyr Gly Asp Tyr Ala Ile Trp Gln Arg Asp 
                165                 170                 175     


Arg Pro Gly Tyr Asp Thr Asp His Ala Tyr Trp Ala Ala Gln Leu Ala 
            180                 185                 190         


Gly Leu Pro Thr Leu Asp Leu Val Thr Asp Arg Ile Arg Pro Pro Glu 
        195                 200                 205             


Gln Thr Tyr Asn Gly Ala Ala His Gly Phe Arg Leu Asn Arg Thr Leu 
    210                 215                 220                 


Thr Asp Ser Val Lys Ala Leu Ala Asp Arg Ser Gln Ala Thr Pro Tyr 
225                 230                 235                 240 


Met Val Leu Leu Ala Ala Phe Gln Ala Leu Leu Ala Arg Tyr Thr Ser 
                245                 250                 255     


Gln Asp Asp Phe Ala Val Gly Ser Pro Val Ala Gly Arg Thr Leu Pro 
            260                 265                 270         


Glu Leu Glu Pro Leu Val Gly Cys Phe Val Asn Met Leu Thr Met Arg 
        275                 280                 285             


Ala Asp Leu Thr Gly Arg Pro Ser Phe Thr Asp Leu Leu Ala Arg Val 
    290                 295                 300                 


Gln Glu Thr Ala Ser Ala Ala Tyr Asp His Gln Glu Leu Pro Phe Glu 
305                 310                 315                 320 


Gln Leu Val Gln Arg Leu Asp Leu Pro Arg Asp Val Ala Arg Ala Pro 
                325                 330                 335     


Leu Phe Gln Val Ile Phe Ala Met Gln Asn Tyr Gln Arg Gly Ser Ala 
            340                 345                 350         


Ala Gly Ala Ser Gly Thr Leu Ser Ala Glu Pro Phe Pro Leu Thr Ser 
        355                 360                 365             


Trp Ala Thr Arg Tyr Asp Leu Glu Leu Tyr Ile Ser Gln Asp Gly Asp 
    370                 375                 380                 


Ala Leu Asp Ala Leu Phe Val Tyr Asn Thr Asp Leu Phe Gly Ala Glu 
385                 390                 395                 400 


Thr Ile Ala Arg Leu Ala Asn His Phe Thr Ala Leu Leu Thr Ala Ala 
                405                 410                 415     


Leu Asp Ala Pro Glu Leu Pro Val Ala Asp Ala Glu Met Leu Asp Ala 
            420                 425                 430         


Ala Glu Arg Ala Arg Leu Leu Ala Asp Phe Asn Ala Thr Thr Ser Asp 
        435                 440                 445             


Phe Pro Gln Asp Lys Thr Leu His Glu Leu Val Glu Ala Gln Cys Ala 
    450                 455                 460                 


Arg Thr Pro Asp Ala Val Ala Ile Glu Phe Glu Gly Glu Ser Leu Thr 
465                 470                 475                 480 


Tyr Arg Glu Val Asn Thr Gln Ala Asp Ala Val Ala Tyr Arg Leu Ser 
                485                 490                 495     


Glu Leu Gly Val Gly Pro Glu Ser Leu Val Ala Val Cys Ala Glu Arg 
            500                 505                 510         


Ser Leu Ala Leu Pro Val Ala Leu Leu Gly Val Leu Lys Ser Gly Ala 
        515                 520                 525             


Ala Tyr Leu Pro Leu Asp Pro Glu Tyr Pro Pro Asp Arg Leu Ala Phe 
    530                 535                 540                 


Met Leu Ala Asp Ala Gly Val Pro Val Ile Leu Ala Gln Arg Gly Leu 
545                 550                 555                 560 


Leu Asp Gln Leu Pro Glu Thr Ser Ala Thr Ile Gln Tyr Leu Asp Glu 
                565                 570                 575     


Ala Thr Asn Leu Ala Ala Pro Pro Gly Trp Arg Ala Pro Arg Gly Asp 
            580                 585                 590         


Leu Ala Tyr Ala Ile Tyr Thr Ser Gly Ser Thr Gly Arg Pro Lys Gly 
        595                 600                 605             


Val Leu Asn Thr His Arg Ala Ile Val Asn Arg Leu Asp Trp Met Gln 
    610                 615                 620                 


Arg Arg Tyr Gln Leu Thr Ala Asp Asp Val Val Leu Gln Lys Thr Pro 
625                 630                 635                 640 


Ala Gly Phe Asp Val Ser Val Trp Glu Phe Phe Trp Pro Leu Leu Ala 
                645                 650                 655     


Gly Ala Arg Leu Val Leu Ala Arg Pro Gly Gly His Lys Asp Ala Gly 
            660                 665                 670         


Tyr Leu Arg Asp Leu Ile Arg Ser Ala Gly Val Thr Thr Ala His Phe 
        675                 680                 685             


Val Pro Ser Met Leu Gly Val Phe Leu Ala Glu Glu Gly Val Glu Gln 
    690                 695                 700                 


Cys Arg Gly Leu Arg Arg Ile Leu Cys Ser Gly Glu Glu Leu Pro Val 
705                 710                 715                 720 


Asp Val Ala Leu Arg Cys Leu Ala Thr Leu Pro Ala Glu Leu His Asn 
                725                 730                 735     


Leu Tyr Gly Pro Thr Glu Ala Ala Ile Asp Val Ser Ser Trp Gln Cys 
            740                 745                 750         


Thr Pro Gln Glu Leu Thr Ala Ala Ala Arg Val Pro Ile Gly Leu Pro 
        755                 760                 765             


Ile Gln Asn Leu Ala Leu His Val Leu Asp Pro Gln Met Gln Pro Val 
    770                 775                 780                 


Pro Ile Gly Val Pro Gly Glu Leu Phe Leu Gly Gly Val Gly Leu Ala 
785                 790                 795                 800 


Arg Gly Tyr Leu Lys Arg Pro Ala Leu Thr Ala Glu Arg Phe Val Pro 
                805                 810                 815     


Asp Pro Phe Gly Thr Pro Gly Ser Arg Leu Tyr Arg Thr Gly Asp Leu 
            820                 825                 830         


Ala Arg Arg Arg Thr Asp Gly Ala Val Glu Phe Leu Gly Arg Ile Asp 
        835                 840                 845             


Gly Gln Val Lys Ile Arg Gly Leu Arg Ile Glu Leu Gly Glu Ile Glu 
    850                 855                 860                 


Ala Ala Leu Arg Asp Gln Pro Gly Val Ala Asp Ala Ala Ala Val Val 
865                 870                 875                 880 


Arg Glu Asp Val Pro Gly Asp Arg Arg Ile Val Gly Tyr Val Val Gly 
                885                 890                 895     


Glu Ala Asp His Ala Ala Leu Arg Thr Ala Leu Lys Gln Arg Leu Pro 
            900                 905                 910         


Asp Tyr Met Val Pro Ser Ala Leu Val Thr Leu Asp Val Leu Pro Leu 
        915                 920                 925             


Thr Pro Asn Gly Lys Leu Asp Arg Arg Ala Leu Pro Glu Pro Gln Arg 
    930                 935                 940                 


Gly Arg Asp Glu Gly Thr Ala Phe Ala Ala Pro Glu Ser Asp Ser Gln 
945                 950                 955                 960 


Arg Leu Ile Ala Gln Ile Trp Ser Asp Val Leu Arg Val Glu Arg Ile 
                965                 970                 975     


Gly Ile Asp Asp Asp Phe Phe Asp Leu Gly Gly His Ser Leu Leu Ala 
            980                 985                 990         


Ala Gln Val Val Ala Lys Leu Arg  Arg Ser Ala Gly Ala  Gly Val Ser 
        995                 1000                 1005             


Val Leu  Asp Leu Phe Lys Asn  Pro Thr Val Arg Gly  Leu Ala Thr 
    1010                 1015                 1020             


Leu Leu  Asp Thr Pro Ala Ala  Glu Arg Gly Pro Ala  Glu Leu Val 
    1025                 1030                 1035             


His Glu  Leu Thr Lys Pro Ile  Pro Val Ala Gln Arg  Thr Leu Ser 
    1040                 1045                 1050             


Phe Val  Cys Val Pro Tyr Gly  Gly Gly Ser Ala Ile  Val Tyr Gln 
    1055                 1060                 1065             


Pro Leu  Ala Asp Ala Leu Pro  Asp Gly His Arg Leu  Phe Ala Val 
    1070                 1075                 1080             


Ala Ile  Pro Gly His Asp Ile  Gly Leu Asp Glu Asp  Ala Leu Pro 
    1085                 1090                 1095             


Phe Asp  Glu Leu Ala Ser Arg  Cys Val Glu Glu Ile  Leu Arg Lys 
    1100                 1105                 1110             


Val Asp  Gly Pro Leu Ala Val  Tyr Gly His Cys Gly  Val Gly Ser 
    1115                 1120                 1125             


Ala Leu  Ala Val Glu Ile Ala  Arg Arg Leu Glu Ala  Ala Gly Arg 
    1130                 1135                 1140             


Arg Leu  Glu Ala Leu Tyr Ile  Gly Ala Ile Phe Pro  Phe Ala Arg 
    1145                 1150                 1155             


Pro Glu  Asn Lys Val Leu Gly  Gly Leu Ser Arg Val  Ala Arg Leu 
    1160                 1165                 1170             


Glu Arg  Phe Arg Ser Asp Arg  Gly Tyr Ala Asn Trp  Leu Leu Ser 
    1175                 1180                 1185             


Met Gly  Val Asp Met Ser Asp  Ile Glu Pro Glu Gln  Ala Thr His 
    1190                 1195                 1200             


Ile Ile  Gln Asn Met Arg Lys  Asp Ser Gln Ser Ala  Glu Asp Tyr 
    1205                 1210                 1215             


Tyr Thr  Gly Leu Leu Arg Asp  Ser Val Asp Arg Leu  Arg Ala Pro 
    1220                 1225                 1230             


Val Ile  Thr Val Ala Gly Asp  Arg Asp Pro Thr Thr  Asp Phe Tyr 
    1235                 1240                 1245             


Ala Glu  Arg Tyr Arg Glu Trp  His Phe Leu Thr Asp  Thr Ser Ala 
    1250                 1255                 1260             


Val Val  Val Leu Asp Glu Ala  Gly His Phe Phe Leu  Lys Tyr Arg 
    1265                 1270                 1275             


Ala Glu  Glu Leu Ala Ala Ile  Val Thr Glu Thr Arg  Pro Ala Leu 
    1280                 1285                 1290             


Glu Thr  Pro Glu Pro Leu Ser  Arg Gln Glu Arg Gly  Ala Asp Ala 
    1295                 1300                 1305             


Gly Trp  Trp Leu His Gly Val  Ser Arg Ser Arg Glu  Arg Val Val 
    1310                 1315                 1320             


Pro Thr  Gly Pro Thr Pro Ser  Met Arg Arg Phe Leu  Ala Val Ala 
    1325                 1330                 1335             


Ser Gly  Gln Leu Val Ser Met  Thr Gly Ser Ala Leu  Thr Glu Phe 
    1340                 1345                 1350             


Ala Val  Pro Leu Trp Ile Tyr  Leu His Thr Gly Ser  Leu Phe Arg 
    1355                 1360                 1365             


Phe Ala  Leu Phe Ala Val Cys  Gly Leu Val Pro Gly  Met Leu Ala 
    1370                 1375                 1380             


Ala Pro  Leu Ala Gly Ala Val  Val Asp Arg Ser Asn  Arg Arg Arg 
    1385                 1390                 1395             


Val Met  Leu Leu Gly Asp Thr  Phe Ala Gly Gly Thr  Gln Leu Ile 
    1400                 1405                 1410             


Leu Gly  Ile Leu Leu Trp Thr  Gly His Leu Gln Ile  Trp His Ile 
    1415                 1420                 1425             


Tyr Pro  Leu Leu Ile Cys Leu  Ser Val Ser Leu Thr  Phe Gln Arg 
    1430                 1435                 1440             


Leu Ala  Tyr Gly Ser Ser Val  Ala Gln Leu Val Pro  Lys His Tyr 
    1445                 1450                 1455             


Leu Gly  His Ala Asn Gly Val  Val Gln Met Ile Asn  Gly Val Ala 
    1460                 1465                 1470             


Gln Ile  Met Val Pro Leu Val  Ala Val Gly Leu Met  Ala Ala Ile 
    1475                 1480                 1485             


Gly Leu  Gly Gly Ile Leu Val  Ile Asp Val Ala Ser  Tyr Ala Val 
    1490                 1495                 1500             


Ala Val  Ala Val Val Leu Ala  Val Arg Phe Pro Ala  Thr Met Ala 
    1505                 1510                 1515             


Trp Arg  Arg Lys Glu Thr Leu  Leu Ala Glu Ile Ala  Glu Gly Phe 
    1520                 1525                 1530             


Arg Tyr  Ser Trp Gly Gln Pro  Gly Leu Arg Ala Met  Leu Leu Phe 
    1535                 1540                 1545             


Phe Ala  Ala Leu Asn Val Phe  Leu Ser Pro Leu Phe  Leu Leu Ile 
    1550                 1555                 1560             


Ser Pro  Leu Val Leu Ser Phe  Thr Thr Leu Ser Arg  Val Gly Glu 
    1565                 1570                 1575             


Val Ala  Leu Ala Ala Gly Ile  Gly Ala Thr Leu Gly  Gly Leu Thr 
    1580                 1585                 1590             


Met Thr  Phe Trp Gly Gly Pro  Arg Arg Leu Arg Met  Arg Gly Met 
    1595                 1600                 1605             


Leu Leu  Cys Thr Leu Ala Leu  Ala Ala Phe Cys Leu  Val Thr Gly 
    1610                 1615                 1620             


Leu Arg  Pro Thr Leu Trp Leu  Ile Ala Val Gly Ala  Phe Gly Met 
    1625                 1630                 1635             


Ser Tyr  Trp Leu Thr Val Val  Asn Gly Ile Tyr Thr  Thr Ile Val 
    1640                 1645                 1650             


Gln Val  Lys Val Ala Gln Arg  Phe His Gly Arg Val  Phe Ala Leu 
    1655                 1660                 1665             


Asn Thr  Leu Ile Ala Trp Ser  Thr Leu Pro Ile Gly  Trp Gly Leu 
    1670                 1675                 1680             


Ile Val  Pro Tyr Gly Thr Lys  Leu Phe Gln Pro His  Ile Gly Arg 
    1685                 1690                 1695             


Met Tyr  Pro Val Leu Ala Ala  Gly Met Val Leu Val  Val Leu Ala 
    1700                 1705                 1710             


Ala Leu  Arg Thr Pro Ala Leu  Arg Arg Phe Asp Ile  Asp Val Pro 
    1715                 1720                 1725             


Asp Ser  Val Pro Asp Asp Leu  Ile Gly Leu Glu Ala  Arg Gln Arg 
    1730                 1735                 1740             


Arg Pro  Arg Thr Ala Glu Pro  Ala Ile Pro Ala Glu  Leu Thr Glu 
    1745                 1750                 1755             


Pro Val  Ala Glu Pro Ala Ala  Gly Ser Val Arg 
    1760                 1765                 


<210>  5
<211>  562
<212>  PRT
<213>  Pyrobaculum aerophilum

<400>  5

Met Ser Val Gln Val Ser Phe Arg Gln Val Ala Ser Val Ala Ala Val 
1               5                   10                  15      


Ala Trp Ser Gly Ala Phe Leu Glu Trp Val Asp Phe Tyr Thr Tyr Ala 
            20                  25                  30          


Leu Leu Ala Val Ile Val Ala Lys Val Phe Phe Pro Ser Ala Asp Pro 
        35                  40                  45              


Ile Ala Ser Leu Leu Ala Ser Phe Ala Ala Leu Ala Ile Gly Phe Leu 
    50                  55                  60                  


Phe Arg Pro Leu Gly Ala Ile Leu Phe Gly Lys Leu Gly Asp Gln Phe 
65                  70                  75                  80  


Gly Arg Lys Ile Ala Phe Ile Ala Ala Met Ile Leu Met Leu Ala Gly 
                85                  90                  95      


Thr Leu Gly Ile Gly Leu Leu Pro Gly Tyr Ala Glu Ile Gly Ile Leu 
            100                 105                 110         


Ala Ser Ile Gly Val Phe Ile Leu Arg Ile Ile Gln Gly Leu Ala Leu 
        115                 120                 125             


Gly Gly Gly Tyr Gly Ala Ala Ile Thr Tyr Leu Gly Glu Phe Val Pro 
    130                 135                 140                 


Glu His Arg Arg Gly Phe Phe Thr Gly Phe Leu Phe Thr Thr Pro Pro 
145                 150                 155                 160 


Ala Gly Met Ala Thr Val Gly Ala Leu Ile Trp Leu Phe Ser Asn Ile 
                165                 170                 175     


Leu Gly Thr Gln Ala Phe Asn Ala Trp Gly Trp Arg Leu Asn Phe Ile 
            180                 185                 190         


Val Ala Gly Val Ile Val Phe Ile Ile Val Leu Ile Met His Met Phe 
        195                 200                 205             


Tyr Lys Glu Thr Pro Val Phe Ser Met Leu Lys Ala Val Arg Arg Val 
    210                 215                 220                 


Thr Ser Ala Pro Ile Arg Glu Val Phe Ser Arg Arg Tyr Leu Pro Leu 
225                 230                 235                 240 


Val Leu Met Ala Trp Ile Gly Val Val Gly Ala His Gly Pro Ile Trp 
                245                 250                 255     


Tyr Thr Asn Gln Leu Phe Asn Ala Tyr Tyr Ile Gly Pro Asn Phe Gln 
            260                 265                 270         


Asn Tyr Val Asp Ala Ala Thr Ala Ser Ala Leu Leu Ser Thr Ala Thr 
        275                 280                 285             


Tyr Ala Ala Leu Trp Met Tyr Pro Leu Phe Gly Tyr Ile Ser Asp Arg 
    290                 295                 300                 


Ile Gly Arg Lys Pro Val Leu Leu Leu Gly Ile Tyr Gly Asn Ala Leu 
305                 310                 315                 320 


Trp Phe Pro Ile Ala Phe Trp Leu Ile Asp Gln Val Gly Pro His Lys 
                325                 330                 335     


Asp Leu Thr Ala Leu Trp Leu Leu Phe Trp Ser Met Thr Leu Phe Asn 
            340                 345                 350         


Gly Ile Gly Tyr Ser Gly Ala Met Ser Ala Phe Leu Leu Glu Leu Phe 
        355                 360                 365             


Pro Ala Arg Ile Arg Leu Ser Ala Val Ala Leu Ala Tyr Asn Leu Gly 
    370                 375                 380                 


Tyr Gly Val Thr Gly Gly Leu Thr Pro Phe Val Ile Thr Trp Ile Tyr 
385                 390                 395                 400 


Ser Ile Thr His Asn Ile Tyr Leu Ser Thr Leu Leu Trp Ser Thr Val 
                405                 410                 415     


Val Pro Met Ile Met Ala Thr Trp Tyr Val Leu Lys Gly Pro Glu Thr 
            420                 425                 430         


Leu Gly Val Arg Ile Trp Ala Glu Phe Ala Thr Glu Lys Phe Ala Lys 
        435                 440                 445             


Lys Thr Val Thr Leu Pro Ala Thr Thr Pro Ile Arg Gln Val Ile Ser 
    450                 455                 460                 


Ala Leu Val Ser Ala Gly Ser Lys Tyr Ala Val Leu Thr Gly Ser Val 
465                 470                 475                 480 


Val Gly Ile Phe Gly Thr Arg Ser Leu Leu Arg Ala Leu Ser Ala Gly 
                485                 490                 495     


Ala Lys Leu Glu Glu Pro Ala Gly Asn Tyr Ala Thr Lys Val Pro Cys 
            500                 505                 510         


Ile Asn Ala Asp His Pro Val Thr Glu Val Phe Val Ala Leu Glu Gln 
        515                 520                 525             


Tyr Asn Val Arg Ala Val Pro Val Cys Lys Gly Asn Glu Val Ile Gly 
    530                 535                 540                 


Ile Val Glu Ala Ser Arg Phe Asn Lys Arg Ile Ala Cys Ala Lys Lys 
545                 550                 555                 560 


Arg Ile 
        


<210>  6
<211>  1429
<212>  PRT
<213>  Emericella nidulans

<400>  6

Met Thr Pro Lys Thr Asp Ala Lys Ala Leu Pro Ile Val Lys Asn Gln 
1               5                   10                  15      


Leu Arg Glu Ile Trp Ala Glu Val Leu Gln Asp Gly Pro Glu Asn Phe 
            20                  25                  30          


Leu Asp Glu Asp Val Phe Phe Asp Val Gly Gly Asp Ser Val Arg Ser 
        35                  40                  45              


Gln Lys Leu Ile Ile Ala Ala Glu Lys Arg Gly Ile Arg Leu Thr Met 
    50                  55                  60                  


Glu Gln Asn Phe Leu Asn Ala Ser Leu Glu Glu Met Ala Gly Val Ala 
65                  70                  75                  80  


Lys Val Val Pro Val Lys Leu Gln Lys Gln Asp Ala Asp Asp Ala Pro 
                85                  90                  95      


Lys Ala Phe Ala Leu Leu Gln Asp Leu Gly Tyr Gly Thr Leu Gln Asp 
            100                 105                 110         


Ile Leu Asp Thr Val Ser Ser Gln Cys Arg Leu Ser Thr Asp Gln Ile 
        115                 120                 125             


Ala Asp Val Tyr Ser Cys Ser Pro Met Gln Glu Ser Leu Val Ala Gln 
    130                 135                 140                 


Leu Asp Gly Val Ala Asn Leu Tyr Val Arg Gln Leu Val Phe Arg Phe 
145                 150                 155                 160 


Ala Gln Ser Thr Pro Leu Asp Val Phe Lys Gln Ala Trp Glu Arg Thr 
                165                 170                 175     


Val Gln Ala Asn Pro Val Leu Arg Thr Arg Ile Cys Val Ala Pro Gly 
            180                 185                 190         


Glu Arg Gly Tyr Leu Gln Ala Val Val Glu Glu Ala Pro Ser Trp Ser 
        195                 200                 205             


Ala Ser Glu Ile Ser Leu Ser Arg Phe Leu Glu Lys Asp Ala Val Asp 
    210                 215                 220                 


Ala Met Asn Pro Gly Val Pro Phe Phe Arg Tyr Ala Leu Val Ala Asp 
225                 230                 235                 240 


Glu Ser His Gln Tyr Phe Val Trp Thr Ala His His Ala Leu Cys Asp 
                245                 250                 255     


Gly Ala Ser Ile Pro Glu Ile Leu Ala Glu Val Ala Met Arg Cys Gln 
            260                 265                 270         


Gly Gln Cys Asp Ala Ile Leu Pro Arg Asp Pro Phe Arg Gly Phe Ile 
        275                 280                 285             


Glu Ser Met Phe Met Pro Asp Pro Glu Arg Gln Gln Gln Gln Arg Leu 
    290                 295                 300                 


Phe Trp Arg His Ser Leu Glu Asp Leu Asn Leu Thr Pro Phe Pro Pro 
305                 310                 315                 320 


Pro Pro Arg Ser Asn Thr Leu Val Asn Pro Ala Ala Thr Val Glu Arg 
                325                 330                 335     


Leu Leu His Phe Gly Gln Gln Gln Met Pro Leu Gly Leu Thr Arg Ala 
            340                 345                 350         


Leu Leu Leu Arg Ala Ala Trp Ala Ile Leu Leu Ser His Tyr Thr Gly 
        355                 360                 365             


Thr Gln Asp Ile Ile Phe Gly Ala Ile Asn Ser Gly Arg Thr Thr Asp 
    370                 375                 380                 


Val Pro Gly Ala Ser Arg Met Thr Gly Pro Thr Ile Asn Leu Val Pro 
385                 390                 395                 400 


Ile Val Leu Arg Val Glu Ala Gln Gln Pro Val Gly Gly Ser Ser Leu 
                405                 410                 415     


Thr Asp Phe Glu Ser Leu Leu Val Val Gln Ser Met Glu Phe Ala Asp 
            420                 425                 430         


Ala Ile Gly Pro Ala Thr Gln Tyr Leu Gly Leu Glu Tyr Val Asp Ala 
        435                 440                 445             


Leu Gly Lys Lys Glu His His Pro Tyr Pro Leu Ile Ala Thr Cys Thr 
    450                 455                 460                 


Ile Leu Thr Asp Ser Thr Val Arg Leu Thr Leu Gln Tyr Asp Glu Gln 
465                 470                 475                 480 


Leu Leu Ser Ala Arg Gln Ala Gly Asn Leu Ser His Gln Phe Glu Ala 
                485                 490                 495     


Val Val Lys Gln Leu Thr Asp Ala Ala Ser Gln Ala Leu Leu Asp Ser 
            500                 505                 510         


Ile Ser Pro Leu Ser Glu His Asp Leu Ala Gln Ile His Glu Trp Asn 
        515                 520                 525             


Lys Leu Thr Pro Ser Pro Glu Glu Thr Cys Leu His His Leu Phe Ala 
    530                 535                 540                 


Trp Gln Val Ser Val Gln Pro Asn Ala Pro Ala Gly Cys Leu Val Arg 
545                 550                 555                 560 


Gly Asp Ile Pro Ile Cys Phe Gly Asn Leu Leu Val Leu Pro Leu Phe 
                565                 570                 575     


Arg Thr Leu Gly Ala Arg Gly Asp Phe His Trp His Phe Thr Gln Ser 
            580                 585                 590         


Pro Val Asn Gly Gly Arg Lys Glu Gln Thr Leu Asn Glu Pro His Ile 
        595                 600                 605             


Val Glu Ser Asn Phe Leu Gln Arg Lys Met Ser Ser Leu Leu Ala Thr 
    610                 615                 620                 


Thr Thr Pro Ala Lys Glu Val Gly Phe Ser Phe Lys Gln Gly Val Asn 
625                 630                 635                 640 


Trp Ser Asp Tyr Leu Asp Tyr Arg Pro Val Tyr Pro Pro Pro Phe Phe 
                645                 650                 655     


Glu Leu Ile Tyr Ser Tyr Arg Ala Gly Glu Leu Gly Ser Ser Trp Ser 
            660                 665                 670         


Glu Ala His Asp Ile Gly Ala Gly Cys Ser Ser Val Ser Ala Gly Leu 
        675                 680                 685             


Ala Ala Lys Phe Pro Ser Trp Asn His Thr Ala Val Ala Ile Arg Glu 
    690                 695                 700                 


Ile Gly Arg Glu Leu Lys Val Gly Gly Thr Leu Ala Val Thr His Tyr 
705                 710                 715                 720 


Thr Val Pro Arg Ile Val Gly Asn Arg Lys Ala Gln Asn Val Trp Lys 
                725                 730                 735     


Ala Ile Trp Glu Glu Tyr Ser Lys Arg Ala Thr Gly Pro Leu Leu Asp 
            740                 745                 750         


His Ala Val Ser Ile Val Asn Thr Ala Leu Asp Cys Leu Glu Ser Pro 
        755                 760                 765             


Gln His Glu Trp Gly Arg Val Asn Ala Gln Gly Ser Ile Glu Ser Tyr 
    770                 775                 780                 


Gln Leu Asp Ser Arg Gly Lys Glu Ser Arg Val Lys Lys Ser Glu Glu 
785                 790                 795                 800 


Val Val Trp Val Glu Gly Asp Asp Asp Trp Ala Asp Glu Gln Asp Val 
                805                 810                 815     


Thr Trp Phe Lys Gly Tyr Leu Ala Thr Trp Val Pro Val Val Pro Gly 
            820                 825                 830         


Asn Glu Ile Gln His Leu Trp Asn Asp Pro Glu Met Ala Leu Gly Gly 
        835                 840                 845             


Gly Lys Thr Arg Ala Leu Arg Ser Tyr Asn Ser Asn Tyr Thr Ile Gly 
    850                 855                 860                 


Ala Ile Asp Arg Pro Val Tyr Tyr Ala Met Ser Asp Tyr Thr Glu Asp 
865                 870                 875                 880 


Arg Ala Pro Asn Lys Ala Val Glu Ser Ser Asp Ser Leu Thr Asn Tyr 
                885                 890                 895     


Asn Pro Ile Pro Glu Asn Glu Lys Gln Gly Thr Val Pro Glu Pro Glu 
            900                 905                 910         


Ala Pro Pro Arg Asp Ile Asp Gly Trp Lys Trp Trp Leu Ser Val Phe 
        915                 920                 925             


Cys Ile Trp Ser Ser Ile Phe Phe Tyr Ala Leu Asp Asn Thr Val Val 
    930                 935                 940                 


Ala Asp Ile Gln Pro Val Ile Ile Glu Ser Leu Gly Glu Leu Glu Lys 
945                 950                 955                 960 


Leu Thr Trp Leu Ser Val Ala Phe Leu Leu Gly Ala Thr Ala Thr Asn 
                965                 970                 975     


Leu Ile Trp Gly Lys Ile Tyr Gly His Phe Asn Val Lys Trp Thr Tyr 
            980                 985                 990         


Leu Phe Asn Val Ala Val Phe Glu  Ile Gly Ser Ala Ile  Cys Gly Ala 
        995                 1000                 1005             


Ala Pro  Ser Met Asn Val Met  Ile Val Gly Arg Ala  Leu Cys Gly 
    1010                 1015                 1020             


Val Ala  Gly Ala Gly Leu Tyr  Val Gly Val Met Thr  Leu Leu Ala 
    1025                 1030                 1035             


Met Thr  Thr Thr Leu Ser Glu  Arg Pro Leu Tyr Val  Gly Gly Thr 
    1040                 1045                 1050             


Gly Leu  Thr Trp Gly Ile Gly  Ile Val Leu Gly Pro  Val Val Gly 
    1055                 1060                 1065             


Gly Gly  Phe Ser Gln Ser Ser  Val Gly Trp Arg Trp  Ala Phe Tyr 
    1070                 1075                 1080             


Ile Asn  Leu Leu Ile Gly Ala  Val Cys Ala Pro Val  Tyr Leu Phe 
    1085                 1090                 1095             


Leu Leu  Pro Thr Lys Asp Pro  Arg Pro Gly Val Ser  Leu Lys Glu 
    1100                 1105                 1110             


Arg Ser  Arg Glu Leu Asp Tyr  Val Gly Ala Ile Leu  Gln Met Gly 
    1115                 1120                 1125             


Ala Leu  Thr Thr Phe Val Leu  Ala Ile Ser Trp Gly  Gly Val Thr 
    1130                 1135                 1140             


Tyr Pro  Trp Asn Ser Gly Gln  Val Ile Gly Cys Phe  Val Ala Ser 
    1145                 1150                 1155             


Gly Val  Leu Phe Ile Ile Leu  Gly Leu Gln Gln Val  Phe Leu Val 
    1160                 1165                 1170             


Leu Thr  Ser Ile Asp Arg Arg  Ile Ile Pro Val Glu  Phe Phe Gly 
    1175                 1180                 1185             


Ser Arg  Thr Val Leu Ile Leu  Phe Ser Ser Thr Ala  Ala Ala Gly 
    1190                 1195                 1200             


Ala Ala  Ala Phe Val Pro Ile  Tyr Met Leu Pro Leu  Phe Phe Gln 
    1205                 1210                 1215             


Phe Thr  Arg Gly Asp Gly Pro  Leu Asp Ala Gly Val  Arg Leu Leu 
    1220                 1225                 1230             


Pro Phe  Ile Ile Leu Met Val  Val Thr Ile Leu Thr  Asn Gly Ala 
    1235                 1240                 1245             


Leu Leu  Ser Lys Leu Gly Tyr  Tyr Met Pro Trp Tyr  Leu Met Gly 
    1250                 1255                 1260             


Gly Leu  Leu Val Val Ala Gly  Gly Ala Leu Met Tyr  Thr Val Asp 
    1265                 1270                 1275             


Leu Ala  Thr Ser Thr Ser Arg  Ile Tyr Gly Tyr Thr  Val Leu Met 
    1280                 1285                 1290             


Gly Val  Gly Val Gly Ala Phe  Ile Gln Ala Ser Phe  Ala Val Ala 
    1295                 1300                 1305             


Gln Ala  Val Val Glu Pro Glu  Gly Val Pro Ala Ala  Val Gly Phe 
    1310                 1315                 1320             


Ile Thr  Leu Ala Gln Phe Ala  Gly Ile Thr Ile Val  Met Ala Ile 
    1325                 1330                 1335             


Ala Asn  Ala Ile Phe Leu Asn  Glu Cys Leu Ser Glu  Ile Pro Lys 
    1340                 1345                 1350             


Ile Leu  Pro Asn Val Ser Arg  Ser Asp Ile Glu Ala  Ala Ile Gln 
    1355                 1360                 1365             


Gly Thr  Ser Asp Leu Leu Asp  Thr Leu Ser Ser Glu  Thr His Thr 
    1370                 1375                 1380             


Gln Val  Leu Asn Ala Ile Val  Ser Gly Ile Ser Lys  Ala Tyr Ala 
    1385                 1390                 1395             


Leu Glu  Ile Ala Ala Gly Ala  Leu Val Ala Val Leu  Ser Leu Leu 
    1400                 1405                 1410             


Met Lys  Arg Glu Arg Leu Phe  Gly Val Ser Ala Ala  Val Ala Ala 
    1415                 1420                 1425             


Ala 
    


