			SEQUENCE LISTING

<110> CODEXIS, INC.
      QUINTANAR-AUDELO, Martina
      EBERHARD, Ellen
      NAZOR, Jovana
      SMITH, Derek
      WANG, Cuixia
 
<120> ENGINEERED TRANSAMINASE POLYPEPTIDES FOR INDUSTRIAL BIOCATALYSIS
 
<130> CX2-129USP1
 
<160> 306

<170>  PatentIn version 3.5 

<210> 1
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 1
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 2
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 2
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 3
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 3
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
agggctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 4
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 4
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 5
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 5
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
cgggctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgatgacccc ggtacagtac                                  990

 
<210> 6
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 6
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Met Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 7
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 7
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggcttgtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 8
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 8
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Cys Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 9
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 9
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc ggattctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 10
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 10
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Asp 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 11
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 11
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gacttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 12
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 12
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Thr 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 13
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 13
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
cgggaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 14
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 14
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Arg Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 15
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 15
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaggaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc taatgacccc ggtacagtac                                  990

 
<210> 16
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 16
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Met Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 17
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 17
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcggtggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 18
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 18
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 19
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 19
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa aagcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 20
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 20
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Lys Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 21
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 21
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gggttctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 22
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 22
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Gly 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 23
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 23
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc ggagtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 24
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 24
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Glu 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 25
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 25
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tttgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 26
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 26
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Phe Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 27
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 27
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
agggaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgatgacccc ggtacagtac                                  990

 
<210> 28
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 28
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Arg Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Met Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 29
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 29
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gaagtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 30
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 30
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Lys 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 31
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 31
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 32
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 32
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 33
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 33
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atggaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 34
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 34
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Met Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 35
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 35
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aatgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 36
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 36
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Asn Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 37
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 37
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgtgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 38
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 38
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 39
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 39
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgcaggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 40
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 40
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Gln Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 41
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 41
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgtttgtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 42
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 42
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 43
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 43
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt acatttggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 44
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 44
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 45
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 45
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt tcagatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 46
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 46
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Gln Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 47
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 47
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt acgtgtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 48
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 48
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Val Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 49
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 49
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt acaagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 50
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 50
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 51
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 51
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt acacttggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 52
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 52
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 53
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 53
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt acgcttggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 54
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 54
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Ala Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 55
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 55
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctactccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 56
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 56
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Thr Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 57
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 57
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg accttgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgcacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 58
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 58
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
His Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 59
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 59
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gcttgcccgt accagtggat cgtaccgttt 480
gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg accgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 60
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 60
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Cys Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 61
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 61
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 62
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 62
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 63
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 63
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttatatgagc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc cggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtat                                  990

 
<210> 64
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 64
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Pro Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 65
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 65
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 66
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 66
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 67
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 67
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggcggtc agttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 68
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 68
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Gln Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 69
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 69
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt gaccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 70
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 70
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 71
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 71
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt gaccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 72
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 72
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 73
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 73
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggcggtc agttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt gaccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 74
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 74
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Gln Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 75
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 75
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggcggtc agttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 76
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 76
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Gln Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 77
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 77
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 78
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 78
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 79
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 79
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attgccggtc agttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt gaccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 80
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 80
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Ala Gly Gln Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 81
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 81
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggcggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatggca gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt gaccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 82
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 82
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ala Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 83
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 83
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggcggtc agttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatggca gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaggacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 84
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 84
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Gln Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ala Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 85
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 85
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtagtgc tttccgtctg 240
ggggaccaca tcgaacgcct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttgcaat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agcactatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa catgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccgacc gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc gatccagtac                                  990

 
<210> 86
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 86
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Ser Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Thr Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Met Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Thr Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Ile Gln Tyr                         
                325                 330                         

 
<210> 87
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 87
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gcccgtatcc cgttgttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttgcaat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa catgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccgacc gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 88
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 88
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Leu Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Ala Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Met Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Thr Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 89
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 89
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agcactatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa catgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccgacc gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 90
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 90
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Thr Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Met Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Thr Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 91
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 91
atggcgttct caaaagacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg cttttgttcc gccgaccgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 92
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 92
Met Ala Phe Ser Lys Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Thr Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 93
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 93
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 94
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 94
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 95
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 95
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 96
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 96
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 97
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 97
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 98
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 98
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 99
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 99
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgaccgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 100
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 100
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Thr Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 101
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 101
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacaagtat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 102
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 102
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 103
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 103
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tactgacccc ggtacagtac                                  990

 
<210> 104
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 104
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 105
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 105
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 106
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 106
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 107
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 107
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acatttcgat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 108
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 108
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Ile Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 109
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 109
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acgtttctat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 110
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 110
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Val Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 111
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 111
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acctttcgat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 112
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 112
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Leu Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 113
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 113
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acaagtcgat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 114
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 114
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Lys Ser Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 115
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 115
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcga ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgagc gctagcccgt acacatggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgtcatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 116
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 116
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Ser Ala Ser Pro Tyr Thr Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 117
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 117
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacctggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 118
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 118
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 119
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 119
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 120
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 120
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 121
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 121
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 122
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 122
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 123
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 123
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 124
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 124
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 125
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 125
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 126
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 126
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 127
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 127
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgacggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 128
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 128
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Thr Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 129
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 129
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 130
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 130
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 131
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 131
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgacggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 132
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 132
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Thr Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 133
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 133
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacccagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 134
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 134
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 135
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 135
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 136
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 136
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 137
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 137
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aatggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 138
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 138
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Asn Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 139
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 139
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 140
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 140
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 141
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 141
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aatggaggtg ctttcgttcc gccgacggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtggat cgtaccgccg 480
gaccgcatcc ggaacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 142
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 142
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Asn Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Thr Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asn Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 143
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 143
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 144
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 144
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 145
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 145
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc ggagtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 146
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 146
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Glu 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 147
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 147
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacccagat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 148
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 148
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Gln Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 149
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 149
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 150
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 150
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 151
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 151
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatccagat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 152
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 152
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Gln Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 153
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 153
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 154
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 154
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 155
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 155
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 156
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 156
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 157
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 157
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacctggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 158
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 158
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 159
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 159
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacctgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatccagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 160
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 160
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Leu Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 161
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 161
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 162
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 162
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 163
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 163
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 164
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 164
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 165
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 165
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacccagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 166
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 166
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 167
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 167
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 168
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 168
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 169
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 169
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 170
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 170
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 171
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 171
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 172
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 172
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 173
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 173
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgacggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 174
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 174
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Thr Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 175
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 175
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 176
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 176
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 177
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 177
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggccggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 178
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 178
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 179
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 179
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc ggagtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 180
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 180
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Glu 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 181
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 181
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacctgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 182
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 182
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Leu Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 183
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 183
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 184
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 184
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 185
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 185
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aatggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacccagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 186
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 186
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Asn Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 187
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 187
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acgtgcagat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 188
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 188
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Val Gln Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 189
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 189
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacccagat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 190
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 190
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Gln Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 191
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 191
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacctgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 192
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 192
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Leu Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 193
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 193
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 194
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 194
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 195
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 195
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 196
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 196
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 197
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 197
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgacggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 198
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 198
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Thr Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 199
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 199
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 200
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 200
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 201
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 201
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatccagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 202
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 202
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 203
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 203
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacacggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 204
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 204
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Arg Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 205
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 205
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 206
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 206
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 207
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 207
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaacagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 208
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 208
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 209
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 209
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 210
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 210
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 211
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 211
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acttagacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 212
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 212
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Leu Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 213
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 213
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 214
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 214
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 215
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 215
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
aaaggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 216
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 216
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Lys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 217
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 217
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
tgcggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaaatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 218
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 218
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Cys Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 219
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 219
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgacggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccgg cctgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacccagat cgtaccgccg 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacgt taccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 220
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 220
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Thr Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Gly Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Gln Ile Val Pro Pro 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 221
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 221
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacctgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gggctctgaa gcgcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 222
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 222
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Leu Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Gly 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 223
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 223
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggcttgcgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gcgcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaagtggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
cgtgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 224
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 224
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Cys Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 225
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 225
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggcttgcgg tgctgcttgg 120
attggaggtg ctttcgttcc gaagtctgaa gcgcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 226
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 226
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Cys Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Lys 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 227
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 227
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggcttgcgg tgctgcttgg 120
attggaggtg ctttcgttcc gggctctgaa gcgcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 228
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 228
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Cys Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Gly 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 229
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 229
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga ggtggctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaagtggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 230
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 230
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 231
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 231
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gggctctgaa gcgcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 232
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 232
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Gly 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 233
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 233
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 234
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 234
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 235
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 235
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggcttgcgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gcgcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
cgtgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ctggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 236
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 236
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Cys Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 237
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 237
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggcttgcgg tgctgcttgg 120
attggaggtg ctttcgttcc gaagtctgaa gcgcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 238
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 238
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Cys Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Lys 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 239
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 239
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gcgcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acatctggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 240
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 240
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 241
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 241
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggcttgcgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtctgaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acacatggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg actgcgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
cgtgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 242
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 242
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Cys Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Thr Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 243
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 243
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggcttgcgg tgctgcttgg 120
attggaggtg ctttcgttcc gccatctgaa gcgcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acgtctggat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accatgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 244
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 244
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Cys Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Val Trp Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         


<210> 245
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 245
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacctgc tggctggcgg tgctgcttgg 120
attggaggtg ctttcgttcc gccatcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaagcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accacgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 246
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 246
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Leu Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 247
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 247
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggcgg tgctgcttgg 120
attggaggtg ctttcgttcc gggttcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gattgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accacgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 248
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 248
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Gly 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 249
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 249
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacctgc tggctggcgg tgctgcttgg 120
attggaggtg ctttcgttcc gccatcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt accttcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accacgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 250
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 250
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Leu Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 251
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 251
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacctgc tggctggcgg tgctgcttgg 120
attggaggtg ctttcgttcc gccatcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatttctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acaagcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accacgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 252
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 252
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Leu Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ser Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Lys Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 253
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 253
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacctgc tggctggcgg tgctgcttgg 120
attggaggtg ctttcgttcc gccatcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gattgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt accttcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg accacgacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
agggctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 254
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 254
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Leu Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 255
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 255
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ttcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 256
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 256
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Phe Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 257
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 257
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ttcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgcaggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttatatgttc gctaccccgt acgttcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gcggctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 258
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 258
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Phe Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Gln Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Thr Pro Tyr Val Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 259
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 259
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ataggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgcaggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttatatgttc gctaccccgt acgttcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg attgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
cgagctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 260
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 260
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Gln Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Thr Pro Tyr Val Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Ile Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 261
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 261
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ttcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acattcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg attgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gcggctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 262
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 262
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Phe Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Ile Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 263
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 263
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ttcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg attgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
cgagctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 264
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 264
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Phe Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Ile Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 265
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 265
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ataggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttatatgttc gctagcccgt acattcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg attgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
cgagctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 266
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 266
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Ile Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 267
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 267
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ttcggaggtg ctttcgttcc gccatcggaa gcacgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acattcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gcggctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 268
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 268
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Phe Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 269
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 269
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacctgc tggctggcgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acattcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 270
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 270
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Leu Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 271
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 271
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ttcggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg attgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 272
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 272
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Phe Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Ile Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 273
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 273
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ataggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgcaggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttatatgttc gctagcccgt acattcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
cgagctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 274
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 274
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Gln Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Ile Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 275
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 275
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
ataggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgcaggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttatatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg attgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
cgagctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 276
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 276
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Gln Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Ile Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Arg Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 277
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 277
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacctctg acgctaccta caccagcttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccatttga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 278
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 278
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Ser Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 279
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 279
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcgagcg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 280
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 280
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Ser Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 281
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 281
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccgtttga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgcgttacca ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 282
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 282
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Val Thr Ile Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 283
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 283
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccgtatga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgcgttaccc ctggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 284
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 284
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Tyr Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Val Thr Pro Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 285
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 285
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccgtttga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtatat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgcagcaccg gcggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 286
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 286
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Tyr Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 287
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 287
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccgataga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtatat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgcgttacca ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 288
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 288
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Ile Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Tyr Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Val Thr Ile Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 289
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 289
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccatttga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaacca ttggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 290
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 290
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ile Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 291
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 291
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccgataga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 292
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 292
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Ile Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 293
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 293
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccgataga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccga tcttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 294
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 294
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Ile Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Ile 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 295
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 295
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccgataga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgtatat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgcagcaccc ctggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 296
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 296
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Ile Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Tyr Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Pro Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 297
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 297
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccatttatga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagttcggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 298
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 298
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Ile Tyr Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Phe 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 299
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 299
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttatgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 300
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 300
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Met Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 301
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 301
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggatgg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 302
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 302
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Met Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 303
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 303
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtttt 180
tatacttctg acgctaccta cgcaaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 304
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 304
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Ala Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         

 
<210> 305
<211> 990
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 305
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat 60
atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg 120
attggaggtg ctttcgttcc gccgtcggaa gctcgtatcc cgatcttcga ccagggtgtt 180
tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg 240
ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg 300
acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa 360
gcgatggtta ccgttacgat cacccgtggt tactcttcta ccccattcga gcgtgacatc 420
accaaacatc gtccgcaggt ttacatgttc gctagcccgt acctgcagat cgtaccgttt 480
gaccgcatcc gggacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt 540
agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag 600
gaaacccacg atcgtggttt cgagttgccg ctgctgctgg acggggacaa cctgctggct 660
gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt 720
gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac 780
gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt 840
tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac 900
ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa 960
ccttcttctc tgctgacccc ggtacagtac                                  990

 
<210> 306
<211> 330
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered transaminase variant
 
<400> 306
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      
Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          
Pro Leu Ala Gly Gly Ala Ala Trp Ile Gly Gly Ala Phe Val Pro Pro 
        35                  40                  45              
Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Val Tyr Thr Ser Asp 
    50                  55                  60                  
Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  
Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      
Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         
Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Thr Val Thr Ile Thr 
        115                 120                 125             
Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 
Pro Gln Val Tyr Met Phe Ala Ser Pro Tyr Leu Gln Ile Val Pro Phe 
145                 150                 155                 160 
Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     
Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         
Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             
Leu Pro Leu Leu Leu Asp Gly Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 
Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 
Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     
Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         
Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             
Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 
Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 
Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr                         
                325                 330                         


