                         SEQUENCE LISTING

<110>  ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
 
<120>  HHLA2 AS A NOVEL INHIBITOR OF HUMAN IMMUNE SYSTEM

<130>  96700-2100

<140>  PCT/US2014/015308
<141>  2014-02-07

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  414
<212>  PRT
<213>  HUMAN

<400>  1

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 


<210>  2
<211>  560
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CHIMERIC SEQUENCE BASED ON A HUMAN SEQUENCE

<400>  2

Arg Ser Leu Ala Phe Phe Ile Tyr Val Pro Met Asn Glu Gln Ile Val 
1               5                   10                  15      


Ile Gly Arg Leu Asp Glu Asp Ile Ile Leu Pro Ser Ser Phe Glu Arg 
            20                  25                  30          


Gly Ser Glu Val Val Ile His Trp Lys Tyr Gln Asp Ser Tyr Lys Val 
        35                  40                  45              


His Ser Tyr Tyr Lys Gly Ser Asp His Leu Glu Ser Gln Asp Pro Arg 
    50                  55                  60                  


Tyr Ala Asn Arg Thr Ser Leu Phe Tyr Asn Glu Ile Gln Asn Gly Asn 
65                  70                  75                  80  


Ala Ser Leu Phe Phe Arg Arg Val Ser Leu Leu Asp Glu Gly Ile Tyr 
                85                  90                  95      


Thr Cys Tyr Val Gly Thr Ala Ile Gln Val Ile Thr Asn Lys Val Val 
            100                 105                 110         


Leu Lys Val Gly Val Phe Leu Thr Pro Val Met Lys Tyr Glu Lys Arg 
        115                 120                 125             


Asn Thr Asn Ser Phe Leu Ile Cys Ser Val Leu Ser Val Tyr Pro Arg 
    130                 135                 140                 


Pro Ile Ile Thr Trp Lys Met Asp Asn Thr Pro Ile Ser Glu Asn Asn 
145                 150                 155                 160 


Met Glu Glu Thr Gly Ser Leu Asp Ser Phe Ser Ile Asn Ser Pro Leu 
                165                 170                 175     


Asn Ile Thr Gly Ser Asn Ser Ser Tyr Glu Cys Thr Ile Glu Asn Ser 
            180                 185                 190         


Leu Leu Lys Gln Thr Trp Thr Gly Arg Trp Thr Met Lys Asp Gly Leu 
        195                 200                 205             


His Lys Met Gln Ser Glu His Val Ser Leu Ser Cys Gln Pro Val Asn 
    210                 215                 220                 


Asp Tyr Phe Ser Pro Asn Gln Asp Phe Lys Val Thr Trp Ser Arg Met 
225                 230                 235                 240 


Lys Ser Gly Thr Phe Ser Val Leu Ala Tyr Tyr Leu Ser Ser Ser Gln 
                245                 250                 255     


Asn Thr Ile Ile Asn Glu Ser Arg Phe Ser Trp Asn Lys Glu Leu Ile 
            260                 265                 270         


Asn Gln Ser Asp Phe Ser Met Asn Leu Met Asp Leu Asn Leu Ser Asp 
        275                 280                 285             


Ser Gly Glu Tyr Leu Cys Asn Ile Ser Ser Asp Glu Tyr Thr Leu Leu 
    290                 295                 300                 


Thr Ile His Thr Val His Val Glu Pro Ser Gln Glu Thr Ala Ser Gly 
305                 310                 315                 320 


Gly Arg Ser Lys Thr Ser Gly Ser Glu Pro Lys Ser Cys Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  3
<211>  1734
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  NUCLEIC ACID ENCODING CHIMERIC SEQUENCE BASED ON HUMAN SEQUENCE

<400>  3
atgaagttat gcatattact ggccgtcgtg gcctttgttg gcctctcgct cgggagatct       60

ttggctttct tcatttatgt tcctatgaat gaacaaatcg tcattggaag acttgatgaa      120

gatataattc tcccttcttc atttgagagg ggatccgaag tcgtaataca ctggaagtat      180

caagatagct ataaggttca tagttactac aaaggcagtg accatttgga aagccaagat      240

cccagatatg caaacaggac atcccttttc tataatgaga ttcaaaatgg gaatgcgtca      300

ctatttttca gaagagtaag ccttctggac gaaggaattt acacctgcta tgtaggaaca      360

gcaattcaag tgattacaaa caaagtggtg ctaaaggtgg gagtttttct cacacccgtg      420

atgaagtatg aaaagaggaa cacaaacagc ttcttaatat gcagcgtgtt aagtgtttat      480

cctcgtccaa ttatcacgtg gaaaatggac aacacaccta tctctgaaaa caacatggaa      540

gaaacagggt ctttggattc tttttctatt aacagcccac tgaatattac aggatcaaat      600

tcatcttatg aatgtacaat tgaaaattca ctgctgaagc aaacatggac agggcgctgg      660

acgatgaaag atggccttca taaaatgcaa agtgaacacg tttcactctc atgtcaacct      720

gtaaatgatt atttttcacc aaaccaagac ttcaaagtta cttggtccag aatgaaaagt      780

gggactttct ctgtcctggc ttactatctg agctcctcac aaaatacaat tatcaatgaa      840

tcccgattct catggaacaa agagctgata aaccagagtg acttctctat gaatttgatg      900

gatcttaatc tttcagacag tggggaatat ttatgcaata tttcttcgga tgaatatact      960

ttacttacca tccacacagt gcatgtagaa ccgagccaag aaacagcttc cggcggccgc     1020

tctaaaacta gtggatccga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc     1080

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1140

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1200

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1260

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1320

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1380

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1440

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1500

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1560

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag     1620

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1680

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1734


<210>  4
<211>  11
<212>  PRT
<213>  HUMAN

<400>  4

Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr 
1               5                   10      


