                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Mnchen
 
<120>  Gene editing in the Oocyte by Cas9 nucleases

<130>  W1319 PCT

<150>  EP 13 15 7063.2
<151>  2013-02-27

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  144
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligodeoxynucleotide 
       ODN-Rab38(G19V)"

<400>  1
cacctcacaa ggagcacctg tacaagctgc tggtgatcgg cgacctggta gtgggcaaga       60

ccagcattat taaacggtac gtgcatcaaa atttctcctc tcattatcga gccaccattg      120

gtgtggactt cgcgctgaag gtgc                                             144


<210>  2
<211>  1411
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: modified Cas9 protein"

<400>  2

Met Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Gly Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr 
            20                  25                  30          


Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
        35                  40                  45              


Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn 
    50                  55                  60                  


Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe 
65                  70                  75                  80  


Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg 
                85                  90                  95      


Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile 
            100                 105                 110         


Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu 
        115                 120                 125             


Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro 
    130                 135                 140                 


Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro 
145                 150                 155                 160 


Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala 
                165                 170                 175     


Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg 
            180                 185                 190         


Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val 
        195                 200                 205             


Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu 
    210                 215                 220                 


Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser 
225                 230                 235                 240 


Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu 
                245                 250                 255     


Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser 
            260                 265                 270         


Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp 
        275                 280                 285             


Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn 
    290                 295                 300                 


Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala 
305                 310                 315                 320 


Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn 
                325                 330                 335     


Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr 
            340                 345                 350         


Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln 
        355                 360                 365             


Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn 
    370                 375                 380                 


Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr 
385                 390                 395                 400 


Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu 
                405                 410                 415     


Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe 
            420                 425                 430         


Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala 
        435                 440                 445             


Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg 
    450                 455                 460                 


Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly 
465                 470                 475                 480 


Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser 
                485                 490                 495     


Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly 
            500                 505                 510         


Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn 
        515                 520                 525             


Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr 
    530                 535                 540                 


Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly 
545                 550                 555                 560 


Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val 
                565                 570                 575     


Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys 
            580                 585                 590         


Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser 
        595                 600                 605             


Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu 
    610                 615                 620                 


Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu 
625                 630                 635                 640 


Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg 
                645                 650                 655     


Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp 
            660                 665                 670         


Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg 
        675                 680                 685             


Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys 
    690                 695                 700                 


Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe 
705                 710                 715                 720 


Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln 
                725                 730                 735     


Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala 
            740                 745                 750         


Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val 
        755                 760                 765             


Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu 
    770                 775                 780                 


Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly 
785                 790                 795                 800 


Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys 
                805                 810                 815     


Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln 
            820                 825                 830         


Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
        835                 840                 845             


Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp 
    850                 855                 860                 


Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp 
865                 870                 875                 880 


Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn 
                885                 890                 895     


Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln 
            900                 905                 910         


Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr 
        915                 920                 925             


Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile 
    930                 935                 940                 


Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln 
945                 950                 955                 960 


Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu 
                965                 970                 975     


Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp 
            980                 985                 990         


Phe Arg Lys Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1010                 1015                 1020             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1025                 1030                 1035             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1040                 1045                 1050             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1055                 1060                 1065             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1070                 1075                 1080             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1085                 1090                 1095             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1100                 1105                 1110             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1115                 1120                 1125             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1130                 1135                 1140             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1145                 1150                 1155             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1160                 1165                 1170             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1175                 1180                 1185             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1190                 1195                 1200             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1205                 1210                 1215             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1220                 1225                 1230             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1235                 1240                 1245             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1250                 1255                 1260             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1265                 1270                 1275             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1280                 1285                 1290             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1295                 1300                 1305             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1310                 1315                 1320             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1325                 1330                 1335             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1340                 1345                 1350             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1355                 1360                 1365             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1370                 1375                 1380             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Lys Arg Pro 
    1385                 1390                 1395             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys 
    1400                 1405                 1410     


<210>  3
<211>  9082
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: plasmid pCAG-Cas9-bpA"

<400>  3
ggcgcgccgg attcgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc       60

attagttcat agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc      120

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      180

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      240

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      300

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      360

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      420

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      480

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      540

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc      600

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag      660

cgcgcggcgg gcgggagtcg ctgcgtcgcg ccttcgcccc gtgccccgct ccgccgccgc      720

ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga      780

cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggctcg tttcttttct      840

gtggctgcgt gaaagcctta aagggctccg ggagggccct ttgtgcgggg gggagcggct      900

cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggcccg cgctgcccgg      960

cggctgtgag cgctgcgggc gcggcgcggg gctttgtgcg ctccgcgtgt gcgcgagggg     1020

agcgcggccg ggggcggtgc cccgcggtgc gggggggctg cgaggggaac aaaggctgcg     1080

tgcggggtgt gtgcgtgggg gggtgagcag ggggtgtggg cgcggcggtc gggctgtaac     1140

ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc     1200

cgtgcggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg     1260

ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc     1320

ggagcgccgg cggctgtcga ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt     1380

gcgagagggc gcagggactt cctttgtccc aaatctggcg gagccgaaat ctgggaggcg     1440

ccgccgcacc ccctctagcg ggcgcgggcg aagcggtgcg gcgccggcag gaaggaaatg     1500

ggcggggagg gccttcgtgc gtcgccgcgc cgccgtcccc ttctccatct ccagcctcgg     1560

ggctgccgca gggggacggc tgccttcggg ggggacgggg cagggcgggg ttcggcttct     1620

ggcgtgtgac cggcggctct agagcctctg ctaaccatgt tcatgccttc ttctttttcc     1680

tacagatcct taattaataa tacgactcac tataggggcc gccaccatgg gacctaagaa     1740

aaagaggaag gtggcggccg ctgactacaa ggatgacgac gataaaggta tccacggagt     1800

cccagcagcc gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg     1860

ggccgtgatc accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac     1920

cgaccggcac agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac     1980

agccgaggcc acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg     2040

gatctgctat ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt     2100

ccacagactg gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat     2160

cttcggcaac atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct     2220

gagaaagaaa ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct     2280

ggcccacatg atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa     2340

cagcgacgtg gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga     2400

aaaccccatc aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa     2460

gagcagacgg ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt     2520

cggcaacctg attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct     2580

ggccgaggat gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct     2640

gctggcccag atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga     2700

cgccatcctg ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag     2760

cgcctctatg atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct     2820

cgtgcggcag cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg     2880

ctacgccggc tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc     2940

catcctggaa aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct     3000

gctgcggaag cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga     3060

gctgcacgcc attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga     3120

aaagatcgag aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg     3180

aaacagcaga ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt     3240

cgaggaagtg gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt     3300

cgataagaac ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt     3360

caccgtgtat aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc     3420

cttcctgagc ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa     3480

agtgaccgtg aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt     3540

ggaaatctcc ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct     3600

gaaaattatc aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga     3660

tatcgtgctg accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac     3720

ctatgcccac ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg     3780

ctggggcagg ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac     3840

aatcctggat ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca     3900

cgacgacagc ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga     3960

tagcctgcac gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct     4020

gcagacagtg aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa     4080

catcgtgatc gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg     4140

cgagagaatg aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga     4200

acaccccgtg gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa     4260

tgggcgggat atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt     4320

ggaccatatc gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac     4380

cagaagcgac aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa     4440

gatgaagaac tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga     4500

caatctgacc aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa     4560

gagacagctg gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg     4620

gatgaacact aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct     4680

gaagtccaag ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat     4740

caacaactac caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat     4800

caaaaagtac cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt     4860

gcggaagatg atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt     4920

ctacagcaac atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg     4980

gaagcggcct ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg     5040

ggattttgcc accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac     5100

cgaggtgcag acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa     5160

gctgatcgcc agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac     5220

cgtggcctat tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa     5280

gagtgtgaaa gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc     5340

catcgacttt ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct     5400

gcctaagtac tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg     5460

cgaactgcag aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct     5520

ggccagccac tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt     5580

tgtggaacag cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa     5640

gagagtgatc ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg     5700

ggataagccc atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct     5760

gggagcccct gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag     5820

caccaaagag gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac     5880

acggatcgac ctgtctcagc tgggaggcga caagcgtcct gctgctacta agaaagctgg     5940

tcaagctaag aaaaagaaat gaacgcgtaa atgattgcag atccactagt tctagagctc     6000

gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg     6060

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa     6120

ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca     6180

gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg     6240

cttctgaggc ggaaagaacc agctggggct cgagatccac tagttctagc ctcgaggcta     6300

gagcggccgc cactggccgt cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc     6360

caacttaatc gccttgcagc acatccccct ttcgccagct ggcgtaatag cgaagaggcc     6420

cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggga cgcgccctgt     6480

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     6540

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     6600

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     6660

cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga     6720

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     6780

caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg     6840

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt     6900

aacaaaatat taacgcttac aatttaggtg gcacttttcg gggaaatgtg cgcggaaccc     6960

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct     7020

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg     7080

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg     7140

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc     7200

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca     7260

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac     7320

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa     7380

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg     7440

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt     7500

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg     7560

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc     7620

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga     7680

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta     7740

ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc     7800

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg     7860

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt     7920

cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa     7980

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     8040

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     8100

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     8160

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     8220

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     8280

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     8340

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     8400

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     8460

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     8520

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     8580

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     8640

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     8700

ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt     8760

ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga     8820

ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc     8880

tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag     8940

cgggcagtga gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt     9000

tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca     9060

caggaaacag ctatgaccat ga                                              9082


<210>  4
<211>  2834
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: plasmid pT7-tracr-RNA"

<220>
<221>  variation
<222>  553
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  554
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  555
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<400>  4
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa      420

tgcatctaga ttaataatac gactcactat agggttggaa ccattcaaaa cagcatagca      480

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt      540

ttgatcagat ccnnnatcgg atcccgggcc cgtcgactgc agaggcctgc atgcaagctt      600

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca      660

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact      720

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct      780

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc      840

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca      900

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg      960

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     1020

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     1080

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     1140

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     1200

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     1260

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     1320

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     1380

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     1440

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     1500

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     1560

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     1620

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     1680

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     1740

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc     1800

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat     1860

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc     1920

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag     1980

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag     2040

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt     2100

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg     2160

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt     2220

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc     2280

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc     2340

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa     2400

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg     2460

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc     2520

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag     2580

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt     2640

cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     2700

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc     2760

acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac     2820

gaggcccttt cgtc                                                       2834


<210>  5
<211>  2848
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: plasmid 
       pT7-crRNA-Rab38"

<220>
<221>  variation
<222>  567
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  568
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  569
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<400>  5
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa      420

tgcatctaga ttaataatac gactcactat aggggtttta gagctatgct gttttgaatg      480

gtcccaaaac cctgtacaag ctgctggtga tcggcgacct gttttagagc tatgctgttt      540

tgaatggtcc caaaacgatc agatccnnna tcggatcccg ggcccgtcga ctgcagaggc      600

ctgcatgcaa gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg      660

ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa      720

tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac      780

ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt      840

gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga      900

gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca      960

ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg     1020

ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt     1080

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc     1140

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct     1200

tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc     1260

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta     1320

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca     1380

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag     1440

tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc tctgctgaag     1500

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt     1560

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa     1620

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg     1680

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga     1740

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta     1800

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc     1860

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg     1920

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga     1980

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt     2040

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt     2100

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc     2160

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc     2220

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca     2280

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag     2340

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg     2400

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa     2460

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa     2520

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga     2580

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga     2640

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg     2700

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt     2760

ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa     2820

aataggcgta tcacgaggcc ctttcgtc                                        2848


<210>  6
<211>  2849
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: plasmid 
       pT7-chRNA-Rab38"

<220>
<221>  variation
<222>  568
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  569
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  570
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<400>  6
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa      420

tgcatctaga ttaataatac gactcactat agggctgctg gtgatcggcg acctgtttta      480

gagctagaaa tagcaagtta aaataaggct agtccgttat caacttgaaa aagtggcacc      540

gagtcggtgc tttttttgat cagatccnnn atcggatccc gggcccgtcg actgcagagg      600

cctgcatgca agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc      660

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta      720

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa      780

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat      840

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg      900

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc      960

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     1020

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     1080

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     1140

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     1200

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     1260

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     1320

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     1380

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     1440

gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa     1500

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     1560

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     1620

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     1680

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     1740

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     1800

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     1860

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     1920

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     1980

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     2040

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     2100

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     2160

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     2220

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     2280

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     2340

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc     2400

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa     2460

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta     2520

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg     2580

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     2640

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     2700

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     2760

tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa     2820

aaataggcgt atcacgaggc cctttcgtc                                       2849


<210>  7
<211>  140
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: Oligodeoxynucleotide 
       ODN-Fus(R513G)"

<400>  7
tgggtagggt agttcagtaa cacgtaatct aacataactt tttctttcag gggcgagcac       60

agacaggatg gcagggagag accatattag cctggctcct gaagttctgg aactcttcct      120

gtacccagtg ttacccttgt                                                  140


<210>  8
<211>  2848
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: plasmid pT7-crRNA-Fus"

<220>
<221>  variation
<222>  567
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  568
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  569
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<400>  8
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa      420

tgcatctaga ttaataatac gactcactat aggggtttta gagctatgct gttttgaatg      480

gtcccaaaac aggggcgagc acagacagga tcgcagggag gttttagagc tatgctgttt      540

tgaatggtcc caaaacgatc agatccnnna tcggatcccg ggcccgtcga ctgcagaggc      600

ctgcatgcaa gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg      660

ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa      720

tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac      780

ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt      840

gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga      900

gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca      960

ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg     1020

ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt     1080

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc     1140

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct     1200

tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc     1260

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta     1320

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca     1380

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag     1440

tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc tctgctgaag     1500

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt     1560

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa     1620

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg     1680

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga     1740

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta     1800

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc     1860

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg     1920

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga     1980

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt     2040

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt     2100

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc     2160

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc     2220

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca     2280

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag     2340

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg     2400

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa     2460

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa     2520

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga     2580

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga     2640

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg     2700

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt     2760

ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa     2820

aataggcgta tcacgaggcc ctttcgtc                                        2848


<210>  9
<211>  2849
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: plasmid pT7-chRNA-Fus"

<220>
<221>  variation
<222>  568
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  569
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<220>
<221>  variation
<222>  570
<223>  /replace="a"
       /replace="c"
       /replace="g"
       /replace="t"

<400>  9
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa      420

tgcatctaga ttaataatac gactcactat agggacagac aggatcgcag ggaggtttta      480

gagctagaaa tagcaagtta aaataaggct agtccgttat caacttgaaa aagtggcacc      540

gagtcggtgc tttttttgat cagatccnnn atcggatccc gggcccgtcg actgcagagg      600

cctgcatgca agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc      660

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta      720

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa      780

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat      840

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg      900

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc      960

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     1020

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     1080

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     1140

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     1200

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     1260

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     1320

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     1380

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     1440

gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa     1500

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     1560

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     1620

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     1680

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     1740

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     1800

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     1860

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     1920

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     1980

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     2040

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     2100

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     2160

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     2220

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     2280

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     2340

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc     2400

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa     2460

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta     2520

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg     2580

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     2640

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     2700

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     2760

tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa     2820

aaataggcgt atcacgaggc cctttcgtc                                       2849


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer Rab-for"

<400>  10
ggcctccagg atgcagacac c                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer Rab-rev"

<400>  11
ccagcaatgt cccagagctg c                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer Fus-for"

<400>  12
ctatggagat gatcgacgtg                                                   20


<210>  13
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: primer Fus-rev"

<400>  13
tggttacaat tagggtagtc tg                                                22


<210>  14
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  14

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  15
<211>  1368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: variant Cas9 (D10A)"

<400>  15

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  16
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: preferred DR sequence 
       for use with the Streptococcus pyogenes Cas9 protein"

<400>  16
gttttagagc tatgctgttt tgaatggtcc caaaac                                 36


<210>  17
<211>  1138
<212>  PRT
<213>  Acidothermus cellulolyticus

<400>  17

Met Gly Gly Ser Glu Val Gly Thr Val Pro Val Thr Trp Arg Leu Gly 
1               5                   10                  15      


Val Asp Val Gly Glu Arg Ser Ile Gly Leu Ala Ala Val Ser Tyr Glu 
            20                  25                  30          


Glu Asp Lys Pro Lys Glu Ile Leu Ala Ala Val Ser Trp Ile His Asp 
        35                  40                  45              


Gly Gly Val Gly Asp Glu Arg Ser Gly Ala Ser Arg Leu Ala Leu Arg 
    50                  55                  60                  


Gly Met Ala Arg Arg Ala Arg Arg Leu Arg Arg Phe Arg Arg Ala Arg 
65                  70                  75                  80  


Leu Arg Asp Leu Asp Met Leu Leu Ser Glu Leu Gly Trp Thr Pro Leu 
                85                  90                  95      


Pro Asp Lys Asn Val Ser Pro Val Asp Ala Trp Leu Ala Arg Lys Arg 
            100                 105                 110         


Leu Ala Glu Glu Tyr Val Val Asp Glu Thr Glu Arg Arg Arg Leu Leu 
        115                 120                 125             


Gly Tyr Ala Val Ser His Met Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Trp Thr Thr Ile Lys Asp Leu Lys Asn Leu Pro Gln Pro Ser Asp Ser 
145                 150                 155                 160 


Trp Glu Arg Thr Arg Glu Ser Leu Glu Ala Arg Tyr Ser Val Ser Leu 
                165                 170                 175     


Glu Pro Gly Thr Val Gly Gln Trp Ala Gly Tyr Leu Leu Gln Arg Ala 
            180                 185                 190         


Pro Gly Ile Arg Leu Asn Pro Thr Gln Gln Ser Ala Gly Arg Arg Ala 
        195                 200                 205             


Glu Leu Ser Asn Ala Thr Ala Phe Glu Thr Arg Leu Arg Gln Glu Asp 
    210                 215                 220                 


Val Leu Trp Glu Leu Arg Cys Ile Ala Asp Val Gln Gly Leu Pro Glu 
225                 230                 235                 240 


Asp Val Val Ser Asn Val Ile Asp Ala Val Phe Cys Gln Lys Arg Pro 
                245                 250                 255     


Ser Val Pro Ala Glu Arg Ile Gly Arg Asp Pro Leu Asp Pro Ser Gln 
            260                 265                 270         


Leu Arg Ala Ser Arg Ala Cys Leu Glu Phe Gln Glu Tyr Arg Ile Val 
        275                 280                 285             


Ala Ala Val Ala Asn Leu Arg Ile Arg Asp Gly Ser Gly Ser Arg Pro 
    290                 295                 300                 


Leu Ser Leu Glu Glu Arg Asn Ala Val Ile Glu Ala Leu Leu Ala Gln 
305                 310                 315                 320 


Thr Glu Arg Ser Leu Thr Trp Ser Asp Ile Ala Leu Glu Ile Leu Lys 
                325                 330                 335     


Leu Pro Asn Glu Ser Asp Leu Thr Ser Val Pro Glu Glu Asp Gly Pro 
            340                 345                 350         


Ser Ser Leu Ala Tyr Ser Gln Phe Ala Pro Phe Asp Glu Thr Ser Ala 
        355                 360                 365             


Arg Ile Ala Glu Phe Ile Ala Lys Asn Arg Arg Lys Ile Pro Thr Phe 
    370                 375                 380                 


Ala Gln Trp Trp Gln Glu Gln Asp Arg Thr Ser Arg Ser Asp Leu Val 
385                 390                 395                 400 


Ala Ala Leu Ala Asp Asn Ser Ile Ala Gly Glu Glu Glu Gln Glu Leu 
                405                 410                 415     


Leu Val His Leu Pro Asp Ala Glu Leu Glu Ala Leu Glu Gly Leu Ala 
            420                 425                 430         


Leu Pro Ser Gly Arg Val Ala Tyr Ser Arg Leu Thr Leu Ser Gly Leu 
        435                 440                 445             


Thr Arg Val Met Arg Asp Asp Gly Val Asp Val His Asn Ala Arg Lys 
    450                 455                 460                 


Thr Cys Phe Gly Val Asp Asp Asn Trp Arg Pro Pro Leu Pro Ala Leu 
465                 470                 475                 480 


His Glu Ala Thr Gly His Pro Val Val Asp Arg Asn Leu Ala Ile Leu 
                485                 490                 495     


Arg Lys Phe Leu Ser Ser Ala Thr Met Arg Trp Gly Pro Pro Gln Ser 
            500                 505                 510         


Ile Val Val Glu Leu Ala Arg Gly Ala Ser Glu Ser Arg Glu Arg Gln 
        515                 520                 525             


Ala Glu Glu Glu Ala Ala Arg Arg Ala His Arg Lys Ala Asn Asp Arg 
    530                 535                 540                 


Ile Arg Ala Glu Leu Arg Ala Ser Gly Leu Ser Asp Pro Ser Pro Ala 
545                 550                 555                 560 


Asp Leu Val Arg Ala Arg Leu Leu Glu Leu Tyr Asp Cys His Cys Met 
                565                 570                 575     


Tyr Cys Gly Ala Pro Ile Ser Trp Glu Asn Ser Glu Leu Asp His Ile 
            580                 585                 590         


Val Pro Arg Thr Asp Gly Gly Ser Asn Arg His Glu Asn Leu Ala Ile 
        595                 600                 605             


Thr Cys Gly Ala Cys Asn Lys Glu Lys Gly Arg Arg Pro Phe Ala Ser 
    610                 615                 620                 


Trp Ala Glu Thr Ser Asn Arg Val Gln Leu Arg Asp Val Ile Asp Arg 
625                 630                 635                 640 


Val Gln Lys Leu Lys Tyr Ser Gly Asn Met Tyr Trp Thr Arg Asp Glu 
                645                 650                 655     


Phe Ser Arg Tyr Lys Lys Ser Val Val Ala Arg Leu Lys Arg Arg Thr 
            660                 665                 670         


Ser Asp Pro Glu Val Ile Gln Ser Ile Glu Ser Thr Gly Tyr Ala Ala 
        675                 680                 685             


Val Ala Leu Arg Asp Arg Leu Leu Ser Tyr Gly Glu Lys Asn Gly Val 
    690                 695                 700                 


Ala Gln Val Ala Val Phe Arg Gly Gly Val Thr Ala Glu Ala Arg Arg 
705                 710                 715                 720 


Trp Leu Asp Ile Ser Ile Glu Arg Leu Phe Ser Arg Val Ala Ile Phe 
                725                 730                 735     


Ala Gln Ser Thr Ser Thr Lys Arg Leu Asp Arg Arg His His Ala Val 
            740                 745                 750         


Asp Ala Val Val Leu Thr Thr Leu Thr Pro Gly Val Ala Lys Thr Leu 
        755                 760                 765             


Ala Asp Ala Arg Ser Arg Arg Val Ser Ala Glu Phe Trp Arg Arg Pro 
    770                 775                 780                 


Ser Asp Val Asn Arg His Ser Thr Glu Glu Pro Gln Ser Pro Ala Tyr 
785                 790                 795                 800 


Arg Gln Trp Lys Glu Ser Cys Ser Gly Leu Gly Asp Leu Leu Ile Ser 
                805                 810                 815     


Thr Ala Ala Arg Asp Ser Ile Ala Val Ala Ala Pro Leu Arg Leu Arg 
            820                 825                 830         


Pro Thr Gly Ala Leu His Glu Glu Thr Leu Arg Ala Phe Ser Glu His 
        835                 840                 845             


Thr Val Gly Ala Ala Trp Lys Gly Ala Glu Leu Arg Arg Ile Val Glu 
    850                 855                 860                 


Pro Glu Val Tyr Ala Ala Phe Leu Ala Leu Thr Asp Pro Gly Gly Arg 
865                 870                 875                 880 


Phe Leu Lys Val Ser Pro Ser Glu Asp Val Leu Pro Ala Asp Glu Asn 
                885                 890                 895     


Arg His Ile Val Leu Ser Asp Arg Val Leu Gly Pro Arg Asp Arg Val 
            900                 905                 910         


Lys Leu Phe Pro Asp Asp Arg Gly Ser Ile Arg Val Arg Gly Gly Ala 
        915                 920                 925             


Ala Tyr Ile Ala Ser Phe His His Ala Arg Val Phe Arg Trp Gly Ser 
    930                 935                 940                 


Ser His Ser Pro Ser Phe Ala Leu Leu Arg Val Ser Leu Ala Asp Leu 
945                 950                 955                 960 


Ala Val Ala Gly Leu Leu Arg Asp Gly Val Asp Val Phe Thr Ala Glu 
                965                 970                 975     


Leu Pro Pro Trp Thr Pro Ala Trp Arg Tyr Ala Ser Ile Ala Leu Val 
            980                 985                 990         


Lys Ala Val Glu Ser Gly Asp Ala  Lys Gln Val Gly Trp  Leu Val Pro 
        995                 1000                 1005             


Gly Asp  Glu Leu Asp Phe Gly  Pro Glu Gly Val Thr  Thr Ala Ala 
    1010                 1015                 1020             


Gly Asp  Leu Ser Met Phe Leu  Lys Tyr Phe Pro Glu  Arg His Trp 
    1025                 1030                 1035             


Val Val  Thr Gly Phe Glu Asp  Asp Lys Arg Ile Asn  Leu Lys Pro 
    1040                 1045                 1050             


Ala Phe  Leu Ser Ala Glu Gln  Ala Glu Val Leu Arg  Thr Glu Arg 
    1055                 1060                 1065             


Ser Asp  Arg Pro Asp Thr Leu  Thr Glu Ala Gly Glu  Ile Leu Ala 
    1070                 1075                 1080             


Gln Phe  Phe Pro Arg Cys Trp  Arg Ala Thr Val Ala  Lys Val Leu 
    1085                 1090                 1095             


Cys His  Pro Gly Leu Thr Val  Ile Arg Arg Thr Ala  Leu Gly Gln 
    1100                 1105                 1110             


Pro Arg  Trp Arg Arg Gly His  Leu Pro Tyr Ser Trp  Arg Pro Trp 
    1115                 1120                 1125             


Ser Ala  Asp Pro Trp Ser Gly  Gly Thr Pro 
    1130                 1135             


<210>  18
<211>  1101
<212>  PRT
<213>  Akkermansia muciniphila

<400>  18

Met Ser Arg Ser Leu Thr Phe Ser Phe Asp Ile Gly Tyr Ala Ser Ile 
1               5                   10                  15      


Gly Trp Ala Val Ile Ala Ser Ala Ser His Asp Asp Ala Asp Pro Ser 
            20                  25                  30          


Val Cys Gly Cys Gly Thr Val Leu Phe Pro Lys Asp Asp Cys Gln Ala 
        35                  40                  45              


Phe Lys Arg Arg Glu Tyr Arg Arg Leu Arg Arg Asn Ile Arg Ser Arg 
    50                  55                  60                  


Arg Val Arg Ile Glu Arg Ile Gly Arg Leu Leu Val Gln Ala Gln Ile 
65                  70                  75                  80  


Ile Thr Pro Glu Met Lys Glu Thr Ser Gly His Pro Ala Pro Phe Tyr 
                85                  90                  95      


Leu Ala Ser Glu Ala Leu Lys Gly His Arg Thr Leu Ala Pro Ile Glu 
            100                 105                 110         


Leu Trp His Val Leu Arg Trp Tyr Ala His Asn Arg Gly Tyr Asp Asn 
        115                 120                 125             


Asn Ala Ser Trp Ser Asn Ser Leu Ser Glu Asp Gly Gly Asn Gly Glu 
    130                 135                 140                 


Asp Thr Glu Arg Val Lys His Ala Gln Asp Leu Met Asp Lys His Gly 
145                 150                 155                 160 


Thr Ala Thr Met Ala Glu Thr Ile Cys Arg Glu Leu Lys Leu Glu Glu 
                165                 170                 175     


Gly Lys Ala Asp Ala Pro Met Glu Val Ser Thr Pro Ala Tyr Lys Asn 
            180                 185                 190         


Leu Asn Thr Ala Phe Pro Arg Leu Ile Val Glu Lys Glu Val Arg Arg 
        195                 200                 205             


Ile Leu Glu Leu Ser Ala Pro Leu Ile Pro Gly Leu Thr Ala Glu Ile 
    210                 215                 220                 


Ile Glu Leu Ile Ala Gln His His Pro Leu Thr Thr Glu Gln Arg Gly 
225                 230                 235                 240 


Val Leu Leu Gln His Gly Ile Lys Leu Ala Arg Arg Tyr Arg Gly Ser 
                245                 250                 255     


Leu Leu Phe Gly Gln Leu Ile Pro Arg Phe Asp Asn Arg Ile Ile Ser 
            260                 265                 270         


Arg Cys Pro Val Thr Trp Ala Gln Val Tyr Glu Ala Glu Leu Lys Lys 
        275                 280                 285             


Gly Asn Ser Glu Gln Ser Ala Arg Glu Arg Ala Glu Lys Leu Ser Lys 
    290                 295                 300                 


Val Pro Thr Ala Asn Cys Pro Glu Phe Tyr Glu Tyr Arg Met Ala Arg 
305                 310                 315                 320 


Ile Leu Cys Asn Ile Arg Ala Asp Gly Glu Pro Leu Ser Ala Glu Ile 
                325                 330                 335     


Arg Arg Glu Leu Met Asn Gln Ala Arg Gln Glu Gly Lys Leu Thr Lys 
            340                 345                 350         


Ala Ser Leu Glu Lys Ala Ile Ser Ser Arg Leu Gly Lys Glu Thr Glu 
        355                 360                 365             


Thr Asn Val Ser Asn Tyr Phe Thr Leu His Pro Asp Ser Glu Glu Ala 
    370                 375                 380                 


Leu Tyr Leu Asn Pro Ala Val Glu Val Leu Gln Arg Ser Gly Ile Gly 
385                 390                 395                 400 


Gln Ile Leu Ser Pro Ser Val Tyr Arg Ile Ala Ala Asn Arg Leu Arg 
                405                 410                 415     


Arg Gly Lys Ser Val Thr Pro Asn Tyr Leu Leu Asn Leu Leu Lys Ser 
            420                 425                 430         


Arg Gly Glu Ser Gly Glu Ala Leu Glu Lys Lys Ile Glu Lys Glu Ser 
        435                 440                 445             


Lys Lys Lys Glu Ala Asp Tyr Ala Asp Thr Pro Leu Lys Pro Lys Tyr 
    450                 455                 460                 


Ala Thr Gly Arg Ala Pro Tyr Ala Arg Thr Val Leu Lys Lys Val Val 
465                 470                 475                 480 


Glu Glu Ile Leu Asp Gly Glu Asp Pro Thr Arg Pro Ala Arg Gly Glu 
                485                 490                 495     


Ala His Pro Asp Gly Glu Leu Lys Ala His Asp Gly Cys Leu Tyr Cys 
            500                 505                 510         


Leu Leu Asp Thr Asp Ser Ser Val Asn Gln His Gln Lys Glu Arg Arg 
        515                 520                 525             


Leu Asp Thr Met Thr Asn Asn His Leu Val Arg His Arg Met Leu Ile 
    530                 535                 540                 


Leu Asp Arg Leu Leu Lys Asp Leu Ile Gln Asp Phe Ala Asp Gly Gln 
545                 550                 555                 560 


Lys Asp Arg Ile Ser Arg Val Cys Val Glu Val Gly Lys Glu Leu Thr 
                565                 570                 575     


Thr Phe Ser Ala Met Asp Ser Lys Lys Ile Gln Arg Glu Leu Thr Leu 
            580                 585                 590         


Arg Gln Lys Ser His Thr Asp Ala Val Asn Arg Leu Lys Arg Lys Leu 
        595                 600                 605             


Pro Gly Lys Ala Leu Ser Ala Asn Leu Ile Arg Lys Cys Arg Ile Ala 
    610                 615                 620                 


Met Asp Met Asn Trp Thr Cys Pro Phe Thr Gly Ala Thr Tyr Gly Asp 
625                 630                 635                 640 


His Glu Leu Glu Asn Leu Glu Leu Glu His Ile Val Pro His Ser Phe 
                645                 650                 655     


Arg Gln Ser Asn Ala Leu Ser Ser Leu Val Leu Thr Trp Pro Gly Val 
            660                 665                 670         


Asn Arg Met Lys Gly Gln Arg Thr Gly Tyr Asp Phe Val Glu Gln Glu 
        675                 680                 685             


Gln Glu Asn Pro Val Pro Asp Lys Pro Asn Leu His Ile Cys Ser Leu 
    690                 695                 700                 


Asn Asn Tyr Arg Glu Leu Val Glu Lys Leu Asp Asp Lys Lys Gly His 
705                 710                 715                 720 


Glu Asp Asp Arg Arg Arg Lys Lys Lys Arg Lys Ala Leu Leu Met Val 
                725                 730                 735     


Arg Gly Leu Ser His Lys His Gln Ser Gln Asn His Glu Ala Met Lys 
            740                 745                 750         


Glu Ile Gly Met Thr Glu Gly Met Met Thr Gln Ser Ser His Leu Met 
        755                 760                 765             


Lys Leu Ala Cys Lys Ser Ile Lys Thr Ser Leu Pro Asp Ala His Ile 
    770                 775                 780                 


Asp Met Ile Pro Gly Ala Val Thr Ala Glu Val Arg Lys Ala Trp Asp 
785                 790                 795                 800 


Val Phe Gly Val Phe Lys Glu Leu Cys Pro Glu Ala Ala Asp Pro Asp 
                805                 810                 815     


Ser Gly Lys Ile Leu Lys Glu Asn Leu Arg Ser Leu Thr His Leu His 
            820                 825                 830         


His Ala Leu Asp Ala Cys Val Leu Gly Leu Ile Pro Tyr Ile Ile Pro 
        835                 840                 845             


Ala His His Asn Gly Leu Leu Arg Arg Val Leu Ala Met Arg Arg Ile 
    850                 855                 860                 


Pro Glu Lys Leu Ile Pro Gln Val Arg Pro Val Ala Asn Gln Arg His 
865                 870                 875                 880 


Tyr Val Leu Asn Asp Asp Gly Arg Met Met Leu Arg Asp Leu Ser Ala 
                885                 890                 895     


Ser Leu Lys Glu Asn Ile Arg Glu Gln Leu Met Glu Gln Arg Val Ile 
            900                 905                 910         


Gln His Val Pro Ala Asp Met Gly Gly Ala Leu Leu Lys Glu Thr Met 
        915                 920                 925             


Gln Arg Val Leu Ser Val Asp Gly Ser Gly Glu Asp Ala Met Val Ser 
    930                 935                 940                 


Leu Ser Lys Lys Lys Asp Gly Lys Lys Glu Lys Asn Gln Val Lys Ala 
945                 950                 955                 960 


Ser Lys Leu Val Gly Val Phe Pro Glu Gly Pro Ser Lys Leu Lys Ala 
                965                 970                 975     


Leu Lys Ala Ala Ile Glu Ile Asp Gly Asn Tyr Gly Val Ala Leu Asp 
            980                 985                 990         


Pro Lys Pro Val Val Ile Arg His  Ile Lys Val Phe Lys  Arg Ile Met 
        995                 1000                 1005             


Ala Leu  Lys Glu Gln Asn Gly  Gly Lys Pro Val Arg  Ile Leu Lys 
    1010                 1015                 1020             


Lys Gly  Met Leu Ile His Leu  Thr Ser Ser Lys Asp  Pro Lys His 
    1025                 1030                 1035             


Ala Gly  Val Trp Arg Ile Glu  Ser Ile Gln Asp Ser  Lys Gly Gly 
    1040                 1045                 1050             


Val Lys  Leu Asp Leu Gln Arg  Ala His Cys Ala Val  Pro Lys Asn 
    1055                 1060                 1065             


Lys Thr  His Glu Cys Asn Trp  Arg Glu Val Asp Leu  Ile Ser Leu 
    1070                 1075                 1080             


Leu Lys  Lys Tyr Gln Met Lys  Arg Tyr Pro Thr Ser  Tyr Thr Gly 
    1085                 1090                 1095             


Thr Pro  Arg 
    1100     


<210>  19
<211>  1062
<212>  PRT
<213>  Actinobacillus succinogenes

<400>  19

Met Asn Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Glu Ile Asp Glu Gln Glu Asn Pro Gln Arg Leu 
            20                  25                  30          


Ile Asp Val Gly Val Arg Thr Phe Asp Arg Ala Glu Val Leu Lys Thr 
        35                  40                  45              


Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ser Arg Arg 
    50                  55                  60                  


Leu Val Lys Arg Arg Ala Glu Arg Ile Lys Lys Ala Lys Arg Leu Leu 
65                  70                  75                  80  


Lys Ala Glu Asn Leu Leu Leu Ser Ala Asp Glu Ile Leu Pro Asn Glu 
                85                  90                  95      


Ala Trp Gln Leu Arg Val Lys Gly Leu Asp Gln Lys Leu Glu Arg Gln 
            100                 105                 110         


Glu Trp Ala Ala Val Leu Leu His Leu Leu Lys His Arg Gly Tyr Leu 
        115                 120                 125             


Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu Gly Ala 
    130                 135                 140                 


Leu Leu Ser Gly Val Ala Ile Asn His Gln Ile Leu Gln Ser Ala Glu 
145                 150                 155                 160 


Tyr Arg Thr Pro Ala Glu Ile Ala Val Asn Lys Phe Gln Ala Glu Glu 
                165                 170                 175     


Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr His Thr Phe Ser Arg 
            180                 185                 190         


Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Gln Arg Gln Ala Thr 
        195                 200                 205             


Leu Gly Asn Pro His Thr Ser Thr Lys Leu Leu Glu Asn Leu Thr Ala 
    210                 215                 220                 


Leu Leu Met Trp Gln Lys Pro Ala Leu Ala Gly Glu Ala Ile Leu Lys 
225                 230                 235                 240 


Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys Ala Ala Lys 
                245                 250                 255     


Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn 
            260                 265                 270         


Leu Arg Ile Leu Glu Gln Gly Ala Glu Arg Ala Leu Thr Asp Asn Glu 
        275                 280                 285             


Arg Phe Ala Leu Leu Asp Gln Pro Tyr Glu Lys Ala Lys Leu Thr Tyr 
    290                 295                 300                 


Ala Gln Val Arg Thr Leu Leu Gly Leu Ser Asp Glu Ala Ile Phe Lys 
305                 310                 315                 320 


Gly Leu Arg Tyr Gln Gly Glu Asp Lys Lys Ala Val Glu Thr Lys Thr 
                325                 330                 335     


Thr Leu Met Glu Val Lys Ala Tyr His Gln Ile Arg Lys Ala Leu Glu 
            340                 345                 350         


Gly Leu Asp Leu Lys Ala Glu Trp Asn Glu Leu Lys Asn Asn Pro Ala 
        355                 360                 365             


Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Asp 
    370                 375                 380                 


Asp Ile His Arg Tyr Leu Asp Gly Lys Leu Ser Glu Ser Val Leu Asn 
385                 390                 395                 400 


Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln Leu Ser Leu 
                405                 410                 415     


Lys Ala Leu Gln Gln Ile Leu Pro Leu Met Leu Gln Gly Gln Arg Tyr 
            420                 425                 430         


Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly Lys Lys Ser 
        435                 440                 445             


Asp Glu Ile Asp Arg Leu Leu Pro Asn Ile Pro Thr Asp Glu Ile Arg 
    450                 455                 460                 


Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile Asn 
465                 470                 475                 480 


Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr 
                485                 490                 495     


Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Lys Lys Leu Glu Lys 
            500                 505                 510         


Gln Gln Glu Glu Asn Arg Lys Gln Arg Glu Asn Ala Val Lys Lys Phe 
        515                 520                 525             


Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly Lys Asp Ile 
    530                 535                 540                 


Leu Lys Met Arg Leu Tyr Glu Leu Gln Gln Ala Lys Cys Leu Tyr Ser 
545                 550                 555                 560 


Gly Lys Ser Leu Glu Leu Tyr Arg Leu Leu Glu Lys Gly Tyr Val Glu 
                565                 570                 575     


Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn 
            580                 585                 590         


Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly Asn Ala 
        595                 600                 605             


Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Gly Trp Gln 
    610                 615                 620                 


His Phe Val Ala Arg Val Gln Thr Ser Gly Phe Ser Tyr Ala Lys Lys 
625                 630                 635                 640 


Gln Arg Val Leu Ile Gln Glu Leu Asp Glu Lys Ser Phe Ile Glu Arg 
                645                 650                 655     


Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn His Ile 
            660                 665                 670         


Ala Asp Asn Met Leu Leu Thr Gly Lys Gly Lys Arg Lys Val Phe Ala 
        675                 680                 685             


Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Cys Trp Gly Leu Gln 
    690                 695                 700                 


Lys Val Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Val Val 
705                 710                 715                 720 


Val Ala Cys Ser Thr Lys Ser Met Gln Asp Lys Ile Thr Lys Phe Val 
                725                 730                 735     


Lys Tyr Lys Glu Gly Arg Leu Phe Lys Asp Lys Lys Asp Gly Val Tyr 
            740                 745                 750         


Lys Gly Glu Arg Ile Asn Arg Glu Thr Gly Glu Ile Ile Ser Leu His 
        755                 760                 765             


Phe Pro Thr Pro Trp Lys Phe Phe Lys Glu Asn Val Glu Ile Arg Ile 
    770                 775                 780                 


Phe Ser Glu Asn Pro Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr 
785                 790                 795                 800 


Pro Gln Tyr Asn His Glu Phe Val Gln Pro Leu Phe Val Ser Arg Met 
                805                 810                 815     


Pro Thr Arg Lys Met Thr Gly Gln Gly His Met Glu Thr Val Lys Ser 
            820                 825                 830         


Ala Lys Arg Leu Asp Lys Gly Leu Ser Val Leu Lys Val Pro Leu Thr 
        835                 840                 845             


Gln Leu Lys Leu Ser Asp Leu Glu Arg Met Val Asn Arg Glu Arg Glu 
    850                 855                 860                 


Met Ala Leu Tyr Glu Ala Leu Lys Glu Cys Leu Glu Gln Phe Gly Asn 
865                 870                 875                 880 


Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Lys Gly Gly Ala 
                885                 890                 895     


Leu Val Lys Ala Val Arg Val Glu Gln Thr Gln Lys Ser Gly Val Leu 
            900                 905                 910         


Val Arg Asn Gly Asn Gly Val Ala Asp Asn Ala Thr Gly Ser Ile Val 
        915                 920                 925             


Arg Val Asp Val Phe Thr Lys Gly Gly Lys Tyr Phe Leu Val Pro Ile 
    930                 935                 940                 


Tyr Thr Trp Gln Val Ala Lys Gly Ile Leu Pro Asn Lys Ala Val Ile 
945                 950                 955                 960 


Gln Gly Lys Asp Glu Ser Glu Trp Glu Glu Met Asp Glu Asn Ala Val 
                965                 970                 975     


Phe Gln Phe Ser Met His Lys Asn Asp Leu Ile Lys Val Lys Thr Lys 
            980                 985                 990         


Lys Gly Glu Ile Phe Gly Tyr Phe  Asn Gly Leu Asp Arg  Ala Thr Gly 
        995                 1000                 1005             


Ser Ile  Glu Ile Glu Glu His  Asp Leu Glu Lys Ser  Lys Gly Lys 
    1010                 1015                 1020             


Asn Gly  Ser His Arg Gly Leu  Gly Val Lys Thr Ala  Phe Phe Leu 
    1025                 1030                 1035             


Glu Lys  Tyr Gln Val Asp Glu  Leu Gly Lys Asn Ile  Arg Pro Cys 
    1040                 1045                 1050             


Arg Pro  Thr Lys Arg Gln His  Val Arg 
    1055                 1060         


<210>  20
<211>  1064
<212>  PRT
<213>  Bradyrhizobium sp. BTAi1

<400>  20

Met Lys Arg Thr Ser Leu Arg Ala Tyr Arg Leu Gly Val Asp Leu Gly 
1               5                   10                  15      


Ala Asn Ser Leu Gly Trp Phe Val Val Trp Leu Asp Asp His Gly Gln 
            20                  25                  30          


Pro Glu Gly Leu Gly Pro Gly Gly Val Arg Ile Phe Pro Asp Gly Arg 
        35                  40                  45              


Asn Pro Gln Ser Lys Gln Ser Asn Ala Ala Gly Arg Arg Leu Ala Arg 
    50                  55                  60                  


Ser Ala Arg Arg Arg Arg Asp Arg Tyr Leu Gln Arg Arg Gly Lys Leu 
65                  70                  75                  80  


Met Gly Leu Leu Val Lys His Gly Leu Met Pro Ala Asp Glu Pro Ala 
                85                  90                  95      


Arg Lys Arg Leu Glu Cys Leu Asp Pro Tyr Gly Leu Arg Ala Lys Ala 
            100                 105                 110         


Leu Asp Glu Val Leu Pro Leu His His Val Gly Arg Ala Leu Phe His 
        115                 120                 125             


Leu Asn Gln Arg Arg Gly Leu Phe Ala Asn Arg Ala Ile Glu Gln Gly 
    130                 135                 140                 


Asp Lys Asp Ala Ser Ala Ile Lys Ala Ala Ala Gly Arg Leu Gln Thr 
145                 150                 155                 160 


Ser Met Gln Ala Cys Gly Ala Arg Thr Leu Gly Glu Phe Leu Asn Arg 
                165                 170                 175     


Arg His Gln Leu Arg Ala Thr Val Arg Ala Arg Ser Pro Val Gly Gly 
            180                 185                 190         


Asp Val Gln Ala Arg Tyr Glu Phe Tyr Pro Thr Arg Ala Met Val Asp 
        195                 200                 205             


Ala Glu Phe Glu Ala Ile Trp Ala Ala Gln Ala Pro His His Pro Thr 
    210                 215                 220                 


Met Thr Ala Glu Ala His Asp Thr Ile Arg Glu Ala Ile Phe Ser Gln 
225                 230                 235                 240 


Arg Ala Met Lys Arg Pro Ser Ile Gly Lys Cys Ser Leu Asp Pro Ala 
                245                 250                 255     


Thr Ser Gln Asp Asp Val Asp Gly Phe Arg Cys Ala Trp Ser His Pro 
            260                 265                 270         


Leu Ala Gln Arg Phe Arg Ile Trp Gln Asp Val Arg Asn Leu Ala Val 
        275                 280                 285             


Val Glu Thr Gly Pro Thr Ser Ser Arg Leu Gly Lys Glu Asp Gln Asp 
    290                 295                 300                 


Lys Val Ala Arg Ala Leu Leu Gln Thr Asp Gln Leu Ser Phe Asp Glu 
305                 310                 315                 320 


Ile Arg Gly Leu Leu Gly Leu Pro Ser Asp Ala Arg Phe Asn Leu Glu 
                325                 330                 335     


Ser Asp Arg Arg Asp His Leu Lys Gly Asp Ala Thr Gly Ala Ile Leu 
            340                 345                 350         


Ser Ala Arg Arg His Phe Gly Pro Ala Trp His Asp Arg Ser Leu Asp 
        355                 360                 365             


Arg Gln Ile Asp Ile Val Ala Leu Leu Glu Ser Ala Leu Asp Glu Ala 
    370                 375                 380                 


Ala Ile Ile Ala Ser Leu Gly Thr Thr His Ser Leu Asp Glu Ala Ala 
385                 390                 395                 400 


Ala Gln Arg Ala Leu Ser Ala Leu Leu Pro Asp Gly Tyr Cys Arg Leu 
                405                 410                 415     


Gly Leu Arg Ala Ile Lys Arg Val Leu Pro Leu Met Glu Ala Gly Arg 
            420                 425                 430         


Thr Tyr Ala Glu Ala Ala Ser Ala Ala Gly Tyr Asp His Ala Leu Leu 
        435                 440                 445             


Pro Gly Gly Lys Leu Ser Pro Thr Gly Tyr Leu Pro Tyr Tyr Gly Gln 
    450                 455                 460                 


Trp Leu Gln Asn Asp Val Val Gly Ser Asp Asp Glu Arg Asp Thr Asn 
465                 470                 475                 480 


Glu Arg Arg Trp Gly Arg Leu Pro Asn Pro Thr Val His Ile Gly Ile 
                485                 490                 495     


Gly Gln Leu Arg Arg Val Val Asn Glu Leu Ile Arg Trp His Gly Pro 
            500                 505                 510         


Pro Ala Glu Ile Thr Val Glu Leu Thr Arg Asp Leu Lys Leu Ser Pro 
        515                 520                 525             


Arg Arg Leu Ala Glu Leu Glu Arg Glu Gln Ala Glu Asn Gln Arg Lys 
    530                 535                 540                 


Asn Asp Lys Arg Thr Ser Leu Leu Arg Lys Leu Gly Leu Pro Ala Ser 
545                 550                 555                 560 


Thr His Asn Leu Leu Lys Leu Arg Leu Trp Asp Glu Gln Gly Asp Val 
                565                 570                 575     


Ala Ser Glu Cys Pro Tyr Thr Gly Glu Ala Ile Gly Leu Glu Arg Leu 
            580                 585                 590         


Val Ser Asp Asp Val Asp Ile Asp His Leu Ile Pro Phe Ser Ile Ser 
        595                 600                 605             


Trp Asp Asp Ser Ala Ala Asn Lys Val Val Cys Met Arg Tyr Ala Asn 
    610                 615                 620                 


Arg Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly His Arg Gln 
625                 630                 635                 640 


Gly Arg Pro Tyr Asp Trp Ala Asp Ile Ala Glu Arg Ala Ala Arg Leu 
                645                 650                 655     


Pro Arg Gly Lys Arg Trp Arg Phe Gly Pro Gly Ala Arg Ala Gln Phe 
            660                 665                 670         


Glu Glu Leu Gly Asp Phe Gln Ala Arg Leu Leu Asn Glu Thr Ser Trp 
        675                 680                 685             


Leu Ala Arg Val Ala Lys Gln Tyr Leu Ala Ala Val Thr His Pro His 
    690                 695                 700                 


Arg Ile His Val Leu Pro Gly Arg Leu Thr Ala Leu Leu Arg Ala Thr 
705                 710                 715                 720 


Trp Glu Leu Asn Asp Leu Leu Pro Gly Ser Asp Asp Arg Ala Ala Lys 
                725                 730                 735     


Ser Arg Lys Asp His Arg His His Ala Ile Asp Ala Leu Val Ala Ala 
            740                 745                 750         


Leu Thr Asp Gln Ala Leu Leu Arg Arg Met Ala Asn Ala His Asp Asp 
        755                 760                 765             


Thr Arg Arg Lys Ile Glu Val Leu Leu Pro Trp Pro Thr Phe Arg Ile 
    770                 775                 780                 


Asp Leu Glu Thr Arg Leu Lys Ala Met Leu Val Ser His Lys Pro Asp 
785                 790                 795                 800 


His Gly Leu Gln Ala Arg Leu His Glu Asp Thr Ala Tyr Gly Thr Val 
                805                 810                 815     


Glu His Pro Glu Thr Glu Asp Gly Ala Asn Leu Val Tyr Arg Lys Thr 
            820                 825                 830         


Phe Val Asp Ile Ser Glu Lys Glu Ile Asp Arg Ile Arg Asp Arg Arg 
        835                 840                 845             


Leu Arg Asp Leu Val Arg Ala His Val Ala Gly Glu Arg Gln Gln Gly 
    850                 855                 860                 


Lys Thr Leu Lys Ala Ala Val Leu Ser Phe Ala Gln Arg Arg Asp Ile 
865                 870                 875                 880 


Ala Gly His Pro Asn Gly Ile Arg His Val Arg Leu Thr Lys Ser Ile 
                885                 890                 895     


Lys Pro Asp Tyr Leu Val Pro Ile Arg Asp Lys Ala Gly Arg Ile Tyr 
            900                 905                 910         


Lys Ser Tyr Asn Ala Gly Glu Asn Ala Phe Val Asp Ile Leu Gln Ala 
        915                 920                 925             


Glu Ser Gly Arg Trp Ile Ala Arg Ala Thr Thr Val Phe Gln Ala Asn 
    930                 935                 940                 


Gln Ala Asn Glu Ser His Asp Ala Pro Ala Ala Gln Pro Ile Met Arg 
945                 950                 955                 960 


Val Phe Lys Gly Asp Met Leu Arg Ile Asp His Ala Gly Ala Glu Lys 
                965                 970                 975     


Phe Val Lys Ile Val Arg Leu Ser Pro Ser Asn Asn Leu Leu Tyr Leu 
            980                 985                 990         


Val Glu His His Gln Ala Gly Val  Phe Gln Thr Arg His  Asp Asp Pro 
        995                 1000                 1005             


Glu Asp  Ser Phe Arg Trp Leu  Phe Ala Ser Phe Asp  Lys Leu Arg 
    1010                 1015                 1020             


Glu Trp  Asn Ala Glu Leu Val  Arg Ile Asp Thr Leu  Gly Gln Pro 
    1025                 1030                 1035             


Trp Arg  Arg Lys Arg Gly Leu  Glu Thr Gly Ser Glu  Asp Ala Thr 
    1040                 1045                 1050             


Arg Ile  Gly Trp Thr Arg Pro  Lys Lys Trp Pro 
    1055                 1060                 


<210>  21
<211>  1436
<212>  PRT
<213>  Bacteroides fragilis 9343

<400>  21

Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Thr Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Thr Glu Glu Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Asn 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Phe Gln Glu Met Asn Thr Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gln Ala Val Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Asp Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 
    450                 455                 460                 


Ala Leu Phe Glu Glu Leu Asn Asp Ala Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Arg Leu Cys Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Ile Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Ala Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 
545                 550                 555                 560 


Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Pro Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Gly Arg Leu Ile Gln Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 
        675                 680                 685             


Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gln Thr 
            740                 745                 750         


Thr Lys Ala His Glu Glu Tyr Lys Thr Leu Leu Gln Thr Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Glu Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gln Leu Ile Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Arg Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Val Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asp  Pro Asn Ala Asn Glu  His Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Met Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Ala Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Ile Thr  Gly Asn Ile Asn Lys  Thr Arg Lys 
    1055                 1060                 1065             


Lys Gly  Gly Val Asn Lys Asn  Met Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Arg  Lys Ile Gly 
    1100                 1105                 1110             


Thr Val  Ser Lys Ser Ala Tyr  Arg Asp Ala Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


Tyr Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Ala  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Met Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Ile Val Thr Leu Glu  Ala Ile Tyr 
    1160                 1165                 1170             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Val Gly Val Arg Lys  Ile Leu Ile Asp Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Lys Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asn Gly  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Val Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Leu  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Thr  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Thr Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Val Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ser Leu Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Arg Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Thr Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210>  22
<211>  1021
<212>  PRT
<213>  Clostridium cellulolyticum

<400>  22

Met Lys Tyr Thr Leu Gly Leu Asp Val Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asp Lys Asp Asn Asn Lys Ile Ile Asp Leu Gly Val Arg 
            20                  25                  30          


Cys Phe Asp Lys Ala Glu Glu Ser Lys Thr Gly Glu Ser Leu Ala Thr 
        35                  40                  45              


Ala Arg Arg Ile Ala Arg Gly Met Arg Arg Arg Ile Ser Arg Arg Ser 
    50                  55                  60                  


Gln Arg Leu Arg Leu Val Lys Lys Leu Phe Val Gln Tyr Glu Ile Ile 
65                  70                  75                  80  


Lys Asp Ser Ser Glu Phe Asn Arg Ile Phe Asp Thr Ser Arg Asp Gly 
                85                  90                  95      


Trp Lys Asp Pro Trp Glu Leu Arg Tyr Asn Ala Leu Ser Arg Ile Leu 
            100                 105                 110         


Lys Pro Tyr Glu Leu Val Gln Val Leu Thr His Ile Thr Lys Arg Arg 
        115                 120                 125             


Gly Phe Lys Ser Asn Arg Lys Glu Asp Leu Ser Thr Thr Lys Glu Gly 
    130                 135                 140                 


Val Val Ile Thr Ser Ile Lys Asn Asn Ser Glu Met Leu Arg Thr Lys 
145                 150                 155                 160 


Asn Tyr Arg Thr Ile Gly Glu Met Ile Phe Met Glu Thr Pro Glu Asn 
                165                 170                 175     


Ser Asn Lys Arg Asn Lys Val Asp Glu Tyr Ile His Thr Ile Ala Arg 
            180                 185                 190         


Glu Asp Leu Leu Asn Glu Ile Lys Tyr Ile Phe Ser Ile Gln Arg Lys 
        195                 200                 205             


Leu Gly Ser Pro Phe Val Thr Glu Lys Leu Glu His Asp Phe Leu Asn 
    210                 215                 220                 


Ile Trp Glu Phe Gln Arg Pro Phe Ala Ser Gly Asp Ser Ile Leu Ser 
225                 230                 235                 240 


Lys Val Gly Lys Cys Thr Leu Leu Lys Glu Glu Leu Arg Ala Pro Thr 
                245                 250                 255     


Ser Cys Tyr Thr Ser Glu Tyr Phe Gly Leu Leu Gln Ser Ile Asn Asn 
            260                 265                 270         


Leu Val Leu Val Glu Asp Asn Asn Thr Leu Thr Leu Asn Asn Asp Gln 
        275                 280                 285             


Arg Ala Lys Ile Ile Glu Tyr Ala His Phe Lys Asn Glu Ile Lys Tyr 
    290                 295                 300                 


Ser Glu Ile Arg Lys Leu Leu Asp Ile Glu Pro Glu Ile Leu Phe Lys 
305                 310                 315                 320 


Ala His Asn Leu Thr His Lys Asn Pro Ser Gly Asn Asn Glu Ser Lys 
                325                 330                 335     


Lys Phe Tyr Glu Met Lys Ser Tyr His Lys Leu Lys Ser Thr Leu Pro 
            340                 345                 350         


Thr Asp Ile Trp Gly Lys Leu His Ser Asn Lys Glu Ser Leu Asp Asn 
        355                 360                 365             


Leu Phe Tyr Cys Leu Thr Val Tyr Lys Asn Asp Asn Glu Ile Lys Asp 
    370                 375                 380                 


Tyr Leu Gln Ala Asn Asn Leu Asp Tyr Leu Ile Glu Tyr Ile Ala Lys 
385                 390                 395                 400 


Leu Pro Thr Phe Asn Lys Phe Lys His Leu Ser Leu Val Ala Met Lys 
                405                 410                 415     


Arg Ile Ile Pro Phe Met Glu Lys Gly Tyr Lys Tyr Ser Asp Ala Cys 
            420                 425                 430         


Asn Met Ala Glu Leu Asp Phe Thr Gly Ser Ser Lys Leu Glu Lys Cys 
        435                 440                 445             


Asn Lys Leu Thr Val Glu Pro Ile Ile Glu Asn Val Thr Asn Pro Val 
    450                 455                 460                 


Val Ile Arg Ala Leu Thr Gln Ala Arg Lys Val Ile Asn Ala Ile Ile 
465                 470                 475                 480 


Gln Lys Tyr Gly Leu Pro Tyr Met Val Asn Ile Glu Leu Ala Arg Glu 
                485                 490                 495     


Ala Gly Met Thr Arg Gln Asp Arg Asp Asn Leu Lys Lys Glu His Glu 
            500                 505                 510         


Asn Asn Arg Lys Ala Arg Glu Lys Ile Ser Asp Leu Ile Arg Gln Asn 
        515                 520                 525             


Gly Arg Val Ala Ser Gly Leu Asp Ile Leu Lys Trp Arg Leu Trp Glu 
    530                 535                 540                 


Asp Gln Gly Gly Arg Cys Ala Tyr Ser Gly Lys Pro Ile Pro Val Cys 
545                 550                 555                 560 


Asp Leu Leu Asn Asp Ser Leu Thr Gln Ile Asp His Ile Tyr Pro Tyr 
                565                 570                 575     


Ser Arg Ser Met Asp Asp Ser Tyr Met Asn Lys Val Leu Val Leu Thr 
            580                 585                 590         


Asp Glu Asn Gln Asn Lys Arg Ser Tyr Thr Pro Tyr Glu Val Trp Gly 
        595                 600                 605             


Ser Thr Glu Lys Trp Glu Asp Phe Glu Ala Arg Ile Tyr Ser Met His 
    610                 615                 620                 


Leu Pro Gln Ser Lys Glu Lys Arg Leu Leu Asn Arg Asn Phe Ile Thr 
625                 630                 635                 640 


Lys Asp Leu Asp Ser Phe Ile Ser Arg Asn Leu Asn Asp Thr Arg Tyr 
                645                 650                 655     


Ile Ser Arg Phe Leu Lys Asn Tyr Ile Glu Ser Tyr Leu Gln Phe Ser 
            660                 665                 670         


Asn Asp Ser Pro Lys Ser Cys Val Val Cys Val Asn Gly Gln Cys Thr 
        675                 680                 685             


Ala Gln Leu Arg Ser Arg Trp Gly Leu Asn Lys Asn Arg Glu Glu Ser 
    690                 695                 700                 


Asp Leu His His Ala Leu Asp Ala Ala Val Ile Ala Cys Ala Asp Arg 
705                 710                 715                 720 


Lys Ile Ile Lys Glu Ile Thr Asn Tyr Tyr Asn Glu Arg Glu Asn His 
                725                 730                 735     


Asn Tyr Lys Val Lys Tyr Pro Leu Pro Trp His Ser Phe Arg Gln Asp 
            740                 745                 750         


Leu Met Glu Thr Leu Ala Gly Val Phe Ile Ser Arg Ala Pro Arg Arg 
        755                 760                 765             


Lys Ile Thr Gly Pro Ala His Asp Glu Thr Ile Arg Ser Pro Lys His 
    770                 775                 780                 


Phe Asn Lys Gly Leu Thr Ser Val Lys Ile Pro Leu Thr Thr Val Thr 
785                 790                 795                 800 


Leu Glu Lys Leu Glu Thr Met Val Lys Asn Thr Lys Gly Gly Ile Ser 
                805                 810                 815     


Asp Lys Ala Val Tyr Asn Val Leu Lys Asn Arg Leu Ile Glu His Asn 
            820                 825                 830         


Asn Lys Pro Leu Lys Ala Phe Ala Glu Lys Ile Tyr Lys Pro Leu Lys 
        835                 840                 845             


Asn Gly Thr Asn Gly Ala Ile Ile Arg Ser Ile Arg Val Glu Thr Pro 
    850                 855                 860                 


Ser Tyr Thr Gly Val Phe Arg Asn Glu Gly Lys Gly Ile Ser Asp Asn 
865                 870                 875                 880 


Ser Leu Met Val Arg Val Asp Val Phe Lys Lys Lys Asp Lys Tyr Tyr 
                885                 890                 895     


Leu Val Pro Ile Tyr Val Ala His Met Ile Lys Lys Glu Leu Pro Ser 
            900                 905                 910         


Lys Ala Ile Val Pro Leu Lys Pro Glu Ser Gln Trp Glu Leu Ile Asp 
        915                 920                 925             


Ser Thr His Glu Phe Leu Phe Ser Leu Tyr Gln Asn Asp Tyr Leu Val 
    930                 935                 940                 


Ile Lys Thr Lys Lys Gly Ile Thr Glu Gly Tyr Tyr Arg Ser Cys His 
945                 950                 955                 960 


Arg Gly Thr Gly Ser Leu Ser Leu Met Pro His Phe Ala Asn Asn Lys 
                965                 970                 975     


Asn Val Lys Ile Asp Ile Gly Val Arg Thr Ala Ile Ser Ile Glu Lys 
            980                 985                 990         


Tyr Asn Val Asp Ile Leu Gly Asn  Lys Ser Ile Val Lys  Gly Glu Pro 
        995                 1000                 1005             


Arg Arg  Gly Met Glu Lys Tyr  Asn Ser Phe Lys Ser  Asn 
    1010                 1015                 1020     


<210>  23
<211>  984
<212>  PRT
<213>  Campylobacter jejuni 11168

<400>  23

Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210>  24
<211>  1426
<212>  PRT
<213>  Capnocytophaga ochracea

<400>  24

Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Tyr Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Pro Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Ile Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ile Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Thr Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Lys Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Pro Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Asn Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Ile Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ile Ser Ala Lys Thr Thr Gln Leu Asp Leu Leu Asn Glu Ser Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Ala Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Lys Val Lys Ala Ile Phe Gln Thr Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Glu Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Lys Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Lys Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Ile Leu Gln Lys Glu Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Ala Pro Ile Ala Arg 
785                 790                 795                 800 


Asp Met Leu Phe Ser Lys Asn Ile Glu Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Thr Phe His 
            820                 825                 830         


Arg Ile Asn Ser Asp Lys Gly Glu Tyr Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Ser Glu Glu Glu Leu Asn Gln Tyr Leu Thr Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Ser Ile Ser Pro Thr Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Asp Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Asp Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asn Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Glu Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Thr 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Ile  Asn Lys Glu Glu Lys  Ile Gly Val Lys Phe  Asp Glu Arg 
    1100                 1105                 1110             


Thr Ile  Ala Lys Val Ser Asn  Pro Val Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Ala 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ser 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Ala Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Asn Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Lys Glu  Ile Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Asp Ala Val  Val Arg Ala 
    1295                 1300                 1305             


Gln Gln  Gly Ile Pro Ile Ile  Asp Lys Thr Tyr Lys  Gln Ala Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Leu Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Ala Thr Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Leu Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Lys Ile Ala Thr Lys  Asp Tyr Phe Phe Arg  His His Leu 
    1370                 1375                 1380             


Glu Thr  Asn Val Glu Thr Asp  Asn Ile Leu Lys Asn  Val Thr Trp 
    1385                 1390                 1395             


Lys Arg  Glu Gly Leu Ser Gly  Leu Lys Asp Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Leu Gly Asp Ile  Val Ser Ile Gly Glu  Tyr 
    1415                 1420                 1425     


<210>  25
<211>  1084
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  25

Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp Tyr Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Thr Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ser Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Thr Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Lys Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Ser Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Gly Phe Asp Pro Lys Glu Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Ser Pro Ser Lys  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Asp  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210>  26
<211>  1079
<212>  PRT
<213>  Dinoroseobacter shibae

<400>  26

Met Arg Leu Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly Trp Trp Leu 
1               5                   10                  15      


Tyr Glu Thr Asp Gly Ala Gly Ser Asp Ala Arg Ile Thr Gly Val Val 
            20                  25                  30          


Asp Gly Gly Val Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Gly 
        35                  40                  45              


Ala Ser Leu Ala Val Asp Arg Arg Ala Ala Arg Ala Met Arg Arg Arg 
    50                  55                  60                  


Arg Asp Arg Tyr Leu Arg Arg Arg Ala Thr Leu Met Lys Val Leu Ala 
65                  70                  75                  80  


Glu Thr Gly Leu Met Pro Ala Asp Pro Ala Glu Ala Lys Ala Leu Glu 
                85                  90                  95      


Ala Leu Asp Pro Phe Ala Leu Arg Ala Ala Gly Leu Asp Glu Pro Leu 
            100                 105                 110         


Pro Leu Pro His Leu Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg 
        115                 120                 125             


Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Gly Asp Asn Glu Ser Gly 
    130                 135                 140                 


Lys Ile Lys Asp Ala Thr Ala Arg Leu Asp Met Glu Met Met Ala Asn 
145                 150                 155                 160 


Gly Ala Arg Thr Tyr Gly Glu Phe Leu His Lys Arg Arg Gln Lys Ala 
                165                 170                 175     


Thr Asp Pro Arg His Val Pro Ser Val Arg Thr Arg Leu Ser Ile Ala 
            180                 185                 190         


Asn Arg Gly Gly Pro Asp Gly Lys Glu Glu Ala Gly Tyr Asp Phe Tyr 
        195                 200                 205             


Pro Asp Arg Arg His Leu Glu Glu Glu Phe His Lys Leu Trp Ala Ala 
    210                 215                 220                 


Gln Gly Ala His His Pro Glu Leu Thr Glu Thr Leu Arg Asp Leu Leu 
225                 230                 235                 240 


Phe Glu Lys Ile Phe Phe Gln Arg Pro Leu Lys Glu Pro Glu Val Gly 
                245                 250                 255     


Leu Cys Leu Phe Ser Gly His His Gly Val Pro Pro Lys Asp Pro Arg 
            260                 265                 270         


Leu Pro Lys Ala His Pro Leu Thr Gln Arg Arg Val Leu Tyr Glu Thr 
        275                 280                 285             


Val Asn Gln Leu Arg Val Thr Ala Asp Gly Arg Glu Ala Arg Pro Leu 
    290                 295                 300                 


Thr Arg Glu Glu Arg Asp Gln Val Ile His Ala Leu Asp Asn Lys Lys 
305                 310                 315                 320 


Pro Thr Lys Ser Leu Ser Ser Met Val Leu Lys Leu Pro Ala Leu Ala 
                325                 330                 335     


Lys Val Leu Lys Leu Arg Asp Gly Glu Arg Phe Thr Leu Glu Thr Gly 
            340                 345                 350         


Val Arg Asp Ala Ile Ala Cys Asp Pro Leu Arg Ala Ser Pro Ala His 
        355                 360                 365             


Pro Asp Arg Phe Gly Pro Arg Trp Ser Ile Leu Asp Ala Asp Ala Gln 
    370                 375                 380                 


Trp Glu Val Ile Ser Arg Ile Arg Arg Val Gln Ser Asp Ala Glu His 
385                 390                 395                 400 


Ala Ala Leu Val Asp Trp Leu Thr Glu Ala His Gly Leu Asp Arg Ala 
                405                 410                 415     


His Ala Glu Ala Thr Ala His Ala Pro Leu Pro Asp Gly Tyr Gly Arg 
            420                 425                 430         


Leu Gly Leu Thr Ala Thr Thr Arg Ile Leu Tyr Gln Leu Thr Ala Asp 
        435                 440                 445             


Val Val Thr Tyr Ala Asp Ala Val Lys Ala Cys Gly Trp His His Ser 
    450                 455                 460                 


Asp Gly Arg Thr Gly Glu Cys Phe Asp Arg Leu Pro Tyr Tyr Gly Glu 
465                 470                 475                 480 


Val Leu Glu Arg His Val Ile Pro Gly Ser Tyr His Pro Asp Asp Asp 
                485                 490                 495     


Asp Ile Thr Arg Phe Gly Arg Ile Thr Asn Pro Thr Val His Ile Gly 
            500                 505                 510         


Leu Asn Gln Leu Arg Arg Leu Val Asn Arg Ile Ile Glu Thr His Gly 
        515                 520                 525             


Lys Pro His Gln Ile Val Val Glu Leu Ala Arg Asp Leu Lys Lys Ser 
    530                 535                 540                 


Glu Glu Gln Lys Arg Ala Asp Ile Lys Arg Ile Arg Asp Thr Thr Glu 
545                 550                 555                 560 


Ala Ala Lys Lys Arg Ser Glu Lys Leu Glu Glu Leu Glu Ile Glu Asp 
                565                 570                 575     


Asn Gly Arg Asn Arg Met Leu Leu Arg Leu Trp Glu Asp Leu Asn Pro 
            580                 585                 590         


Asp Asp Ala Met Arg Arg Phe Cys Pro Tyr Thr Gly Thr Arg Ile Ser 
        595                 600                 605             


Ala Ala Met Ile Phe Asp Gly Ser Cys Asp Val Asp His Ile Leu Pro 
    610                 615                 620                 


Tyr Ser Arg Thr Leu Asp Asp Ser Phe Pro Asn Arg Thr Leu Cys Leu 
625                 630                 635                 640 


Arg Glu Ala Asn Arg Gln Lys Arg Asn Gln Thr Pro Trp Gln Ala Trp 
                645                 650                 655     


Gly Asp Thr Pro His Trp His Ala Ile Ala Ala Asn Leu Lys Asn Leu 
            660                 665                 670         


Pro Glu Asn Lys Arg Trp Arg Phe Ala Pro Asp Ala Met Thr Arg Phe 
        675                 680                 685             


Glu Gly Glu Asn Gly Phe Leu Asp Arg Ala Leu Lys Asp Thr Gln Tyr 
    690                 695                 700                 


Leu Ala Arg Ile Ser Arg Ser Tyr Leu Asp Thr Leu Phe Thr Lys Gly 
705                 710                 715                 720 


Gly His Val Trp Val Val Pro Gly Arg Phe Thr Glu Met Leu Arg Arg 
                725                 730                 735     


His Trp Gly Leu Asn Ser Leu Leu Ser Asp Ala Gly Arg Gly Ala Val 
            740                 745                 750         


Lys Ala Lys Asn Arg Thr Asp His Arg His His Ala Ile Asp Ala Ala 
        755                 760                 765             


Val Ile Ala Ala Thr Asp Pro Gly Leu Leu Asn Arg Ile Ser Arg Ala 
    770                 775                 780                 


Ala Gly Gln Gly Glu Ala Ala Gly Gln Ser Ala Glu Leu Ile Ala Arg 
785                 790                 795                 800 


Asp Thr Pro Pro Pro Trp Glu Gly Phe Arg Asp Asp Leu Arg Val Arg 
                805                 810                 815     


Leu Asp Arg Ile Ile Val Ser His Arg Ala Asp His Gly Arg Ile Asp 
            820                 825                 830         


His Ala Ala Arg Lys Gln Gly Arg Asp Ser Thr Ala Gly Gln Leu His 
        835                 840                 845             


Gln Glu Thr Ala Tyr Ser Ile Val Asp Asp Ile His Val Ala Ser Arg 
    850                 855                 860                 


Thr Asp Leu Leu Ser Leu Lys Pro Ala Gln Leu Leu Asp Glu Pro Gly 
865                 870                 875                 880 


Arg Ser Gly Gln Val Arg Asp Pro Gln Leu Arg Lys Ala Leu Arg Val 
                885                 890                 895     


Ala Thr Gly Gly Lys Thr Gly Lys Asp Phe Glu Asn Ala Leu Arg Tyr 
            900                 905                 910         


Phe Ala Ser Lys Pro Gly Pro Tyr Gln Ala Ile Arg Arg Val Arg Ile 
        915                 920                 925             


Ile Lys Pro Leu Gln Ala Gln Ala Arg Val Pro Val Pro Ala Gln Asp 
    930                 935                 940                 


Pro Ile Lys Ala Tyr Gln Gly Gly Ser Asn His Leu Phe Glu Ile Trp 
945                 950                 955                 960 


Arg Leu Pro Asp Gly Glu Ile Glu Ala Gln Val Ile Thr Ser Phe Glu 
                965                 970                 975     


Ala His Thr Leu Glu Gly Glu Lys Arg Pro His Pro Ala Ala Lys Arg 
            980                 985                 990         


Leu Leu Arg Val His Lys Gly Asp  Met Val Ala Leu Glu  Arg Asp Gly 
        995                 1000                 1005             


Arg Arg  Val Val Gly His Val  Gln Lys Met Asp Ile  Ala Asn Gly 
    1010                 1015                 1020             


Leu Phe  Ile Val Pro His Asn  Glu Ala Asn Ala Asp  Thr Arg Asn 
    1025                 1030                 1035             


Asn Asp  Lys Ser Asp Pro Phe  Lys Trp Ile Gln Ile  Gly Ala Arg 
    1040                 1045                 1050             


Pro Ala  Ile Ala Ser Gly Ile  Arg Arg Val Ser Val  Asp Glu Ile 
    1055                 1060                 1065             


Gly Arg  Leu Arg Asp Gly Gly  Thr Arg Pro Ile 
    1070                 1075                 


<210>  27
<211>  1131
<212>  PRT
<213>  Diaphorobacter sp. TPSY

<400>  27

Met Ala Gln His Val Phe Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Trp Ala Ile Leu Gly Glu Gln Arg Ile Ile Asp Leu Gly Val Arg Cys 
            20                  25                  30          


Phe Asp Lys Ala Glu Thr Ala Lys Glu Gly Asp Pro Leu Asn Leu Thr 
        35                  40                  45              


Arg Arg Gln Ala Arg Leu Leu Arg Arg Arg Leu Tyr Arg Arg Ala Trp 
    50                  55                  60                  


Arg Leu Thr Gln Leu Ser Arg Leu Leu Lys Arg Lys Gly Leu Ile Ala 
65                  70                  75                  80  


Asp Ala Lys Leu Phe Ala Lys Ala Pro Ser Tyr Gly Asp Ser Ala Trp 
                85                  90                  95      


Glu Leu Arg Arg Gln Gly Leu Asp Arg Leu Leu Thr Pro Leu Glu Trp 
            100                 105                 110         


Ala Arg Val Ile Tyr His Gln Cys Lys His Arg Gly Phe His Trp Thr 
        115                 120                 125             


Ser Lys Ala Glu Glu Ala Lys Ala Asp Ser Asp Ala Glu Gly Gly Arg 
    130                 135                 140                 


Val Lys Gln Gly Leu Ala His Thr Lys Ala Leu Met Gln Ala Lys Asn 
145                 150                 155                 160 


Tyr Arg Ser Ala Ala Glu Met Val Leu Ala Glu Phe Pro Asp Ala Gln 
                165                 170                 175     


Arg Asn Lys Arg Gly Gln Tyr Asp Lys Ala Leu Ser Arg Val Leu Leu 
            180                 185                 190         


Gly Glu Glu Leu Ala Leu Leu Phe Ala Thr Gln Arg Arg Leu Gly Asn 
        195                 200                 205             


Pro His Ala Ser Asp Phe Phe Glu Lys Leu Ile Leu Gly Asp Gly Asp 
    210                 215                 220                 


Arg Lys Ser Gly Leu Phe Trp Gln Gln Lys Pro Ala Leu Ser Gly Ala 
225                 230                 235                 240 


Asp Leu Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Lys Gly Glu Tyr 
                245                 250                 255     


Arg Ala Pro Lys Ala Ser Phe Ser Val Glu Arg His Val Trp Leu Thr 
            260                 265                 270         


Arg Leu Asn Asn Leu Arg Ile Val Val Asp Gly Arg Ser Arg Pro Leu 
        275                 280                 285             


Asn Glu Ala Glu Arg Gln Ala Ala Leu Leu Leu Pro Tyr Gln Thr Glu 
    290                 295                 300                 


Thr Ser Lys Tyr Lys Thr Leu Lys Asn Ala Phe Ile Lys Ala Gly Leu 
305                 310                 315                 320 


Trp Gly Asp Gly Val Arg Phe Gly Gly Leu Ala Tyr Pro Ser Gln Ala 
                325                 330                 335     


Gln Ile Asp Ala Glu Lys Thr Lys Asp Pro Glu Asp Gln Phe Leu Val 
            340                 345                 350         


Lys Leu Pro Ala Trp His Glu Leu Arg Lys Ala Phe Lys Ala Ala Gly 
        355                 360                 365             


His Glu Ala Leu Trp Gln Gln Ile Ser Thr Pro Ala Leu Asp Gly Asp 
    370                 375                 380                 


Pro Thr Leu Leu Asp Gln Ile Ala Thr Val Leu Ser Val Tyr Lys Asp 
385                 390                 395                 400 


Gly Ala Glu Val Val Gln Gln Leu Arg Gln Leu Ala Leu Pro Glu Pro 
                405                 410                 415     


Ala Ala Ser Ile Ala Val Leu Glu Lys Ile Ser Phe Asp Lys Phe Ser 
            420                 425                 430         


Ser Leu Ser Leu Lys Ala Leu Arg Arg Ile Val Pro Leu Met Gln Ser 
        435                 440                 445             


Gly Leu Arg Tyr Asp Glu Ala Val Ala Gln Ile Pro Glu Tyr Gly His 
    450                 455                 460                 


His Ser Gln Arg Ile Glu Pro Gly Ala Ala Lys His Leu Tyr Leu Pro 
465                 470                 475                 480 


Pro Phe Tyr Glu Ala Gln Arg Lys Tyr Ala Gly Lys Gly Asp His Ile 
                485                 490                 495     


Gly Ser Met Gln Phe Arg Asp Asp Ala Asp Ile Pro Arg Asn Pro Val 
            500                 505                 510         


Val Leu Arg Ala Leu Asn Gln Ala Arg Lys Val Val Asn Ala Leu Ile 
        515                 520                 525             


Arg Glu Tyr Gly Ser Pro Ile Ala Val Asn Ile Glu Met Ala Arg Asp 
    530                 535                 540                 


Leu Ser Arg Pro Leu Asp Glu Arg Asn Lys Val Lys Arg Ala Gln Glu 
545                 550                 555                 560 


Glu Phe Arg Asp Arg Asn Asp Arg Ala Arg Ser Glu Phe Glu Arg Asp 
                565                 570                 575     


Phe Gly Tyr Lys Pro Lys Ala Ala Ala Phe Glu Lys Trp Met Leu Tyr 
            580                 585                 590         


Arg Glu Gln Leu Gly Gln Cys Ala Tyr Ser Gln Gln Pro Leu Asp Ile 
        595                 600                 605             


Gln Arg Val Leu Asp Asp His Asn Tyr Ala Gln Val Asp His Ala Leu 
    610                 615                 620                 


Pro Tyr Ser Arg Ser Tyr Asp Asp Ser Lys Asn Asn Lys Val Leu Val 
625                 630                 635                 640 


Leu Thr His Glu Asn Gln Asn Lys Gly Asn Arg Thr Ala Phe Glu Tyr 
                645                 650                 655     


Leu Thr Ser Phe Pro Asp Gly Glu Asp Gly Glu Arg Trp Arg Thr Phe 
            660                 665                 670         


Val Ala Trp Val Gln Gly Asn Lys Ala Tyr Arg Met Ala Lys Arg Asn 
        675                 680                 685             


Arg Leu Leu Arg Lys Asn Tyr Gly Val Asp Glu Ser Lys Gly Phe Ile 
    690                 695                 700                 


Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile Cys Lys Phe Phe Lys Asn 
705                 710                 715                 720 


Tyr Val Glu Glu His Leu Gln Leu Ala Ala Arg Ala Asp Gly Asp Thr 
                725                 730                 735     


Ala Arg Arg Cys Val Val Val Asn Gly Gln Leu Thr Ala Phe Leu Arg 
            740                 745                 750         


Ala Arg Trp Gly Leu Thr Lys Val Arg Gly Asp Ser Asp Arg His His 
        755                 760                 765             


Ala Leu Asp Ala Ala Val Val Ala Ala Cys Thr His Gly Met Val Lys 
    770                 775                 780                 


Ala Leu Ala Asp Tyr Ser Arg Arg Lys Glu Ile Ser Phe Leu Gln Glu 
785                 790                 795                 800 


Gly Phe Pro Asp Pro Glu Thr Gly Glu Ile Leu Asn Pro Ala Ala Phe 
                805                 810                 815     


Asp Arg Ala Arg Gln His Phe Pro Glu Pro Trp Thr His Phe Ala His 
            820                 825                 830         


Glu Leu Lys Ala Arg Leu Phe Thr Asp Asp Leu Ala Ala Leu Arg Glu 
        835                 840                 845             


Asp Met Gln Arg Leu Gly Ser Tyr Thr Thr Glu Asp Leu Gly Arg Leu 
    850                 855                 860                 


Arg Thr Leu Phe Val Ser Arg Ala Pro Gln Arg Arg Ser Gly Gly Ala 
865                 870                 875                 880 


Val His Lys Glu Thr Ile Tyr Ala Gln Pro Glu Ser Leu Lys Gln Gln 
                885                 890                 895     


Gly Gly Val Ile Glu Lys Ile Leu Leu Thr Ser Leu Lys Leu Gln Asp 
            900                 905                 910         


Phe Asp Lys Leu Leu Asn Pro Glu Ser Asn Asp His Phe Val Glu Pro 
        915                 920                 925             


His Arg Asn Glu Arg Leu Tyr Ala Ala Ile Arg Gln Arg Leu Glu Gln 
    930                 935                 940                 


Phe Gly Gly Arg Ala Asp Lys Ala Phe Gly Pro Asp Asn Leu Phe His 
945                 950                 955                 960 


Lys Pro Asp Lys Asn Asn Gln Pro Thr Gly Pro Val Val Arg Ser Ile 
                965                 970                 975     


Lys Leu Val Arg Gly Lys Gln Thr Gly Ile Pro Ile Arg Gly Gly Leu 
            980                 985                 990         


Ala Lys Asn Asp Ser Met Leu Arg  Val Asp Ile Phe Thr  Lys Ala Gly 
        995                 1000                 1005             


Lys Phe  His Leu Val Pro Val  Tyr Val His His Arg  Val Thr Gly 
    1010                 1015                 1020             


Leu Pro  Asn Arg Ala Ile Val  Ala Phe Lys Asp Glu  Asp Glu Trp 
    1025                 1030                 1035             


Thr Leu  Ile Asp Glu Ser Phe  Ala Phe Leu Phe Ser  Val Tyr Pro 
    1040                 1045                 1050             


Asn Asp  Tyr Val Lys Val Thr  Leu Lys Lys Glu Gln  Gln Ser Gly 
    1055                 1060                 1065             


Tyr Tyr  Ser Gly Ala Asp Arg  Ser Thr Gly Ala Met  Asn Leu Trp 
    1070                 1075                 1080             


Ala His  Asp Arg Ala Ala Ser  Val Gly Lys Asp Gly  Leu Ile Arg 
    1085                 1090                 1095             


Gly Ile  Gly Val Lys Thr Ala  Leu Ser Val Glu Lys  Phe Asn Val 
    1100                 1105                 1110             


Asp Val  Leu Gly Arg Ile Tyr  Leu Ala Pro Pro Glu  Thr Arg Ser 
    1115                 1120                 1125             


Gly Leu  Ala 
    1130     


<210>  28
<211>  1195
<212>  PRT
<213>  Elusimicrobium minutum

<400>  28

Met Gln Lys Asn Ile Asn Thr Lys Gln Asn His Ile Tyr Ile Lys Gln 
1               5                   10                  15      


Ala Gln Lys Ile Lys Glu Lys Leu Gly Asp Lys Pro Tyr Arg Ile Gly 
            20                  25                  30          


Leu Asp Leu Gly Val Gly Ser Ile Gly Phe Ala Ile Val Ser Met Glu 
        35                  40                  45              


Glu Asn Asp Gly Asn Val Leu Leu Pro Lys Glu Ile Ile Met Val Gly 
    50                  55                  60                  


Ser Arg Ile Phe Lys Ala Ser Ala Gly Ala Ala Asp Arg Lys Leu Ser 
65                  70                  75                  80  


Arg Gly Gln Arg Asn Asn His Arg His Thr Arg Glu Arg Met Arg Tyr 
                85                  90                  95      


Leu Trp Lys Val Leu Ala Glu Gln Lys Leu Ala Leu Pro Val Pro Ala 
            100                 105                 110         


Asp Leu Asp Arg Lys Glu Asn Ser Ser Glu Gly Glu Thr Ser Ala Lys 
        115                 120                 125             


Arg Phe Leu Gly Asp Val Leu Gln Lys Asp Ile Tyr Glu Leu Arg Val 
    130                 135                 140                 


Lys Ser Leu Asp Glu Arg Leu Ser Leu Gln Glu Leu Gly Tyr Val Leu 
145                 150                 155                 160 


Tyr His Ile Ala Gly His Arg Gly Ser Ser Ala Ile Arg Thr Phe Glu 
                165                 170                 175     


Asn Asp Ser Glu Glu Ala Gln Lys Glu Asn Thr Glu Asn Lys Lys Ile 
            180                 185                 190         


Ala Gly Asn Ile Lys Arg Leu Met Ala Lys Lys Asn Tyr Arg Thr Tyr 
        195                 200                 205             


Gly Glu Tyr Leu Tyr Lys Glu Phe Phe Glu Asn Lys Glu Lys His Lys 
    210                 215                 220                 


Arg Glu Lys Ile Ser Asn Ala Ala Asn Asn His Lys Phe Ser Pro Thr 
225                 230                 235                 240 


Arg Asp Leu Val Ile Lys Glu Ala Glu Ala Ile Leu Lys Lys Gln Ala 
                245                 250                 255     


Gly Lys Asp Gly Phe His Lys Glu Leu Thr Glu Glu Tyr Ile Glu Lys 
            260                 265                 270         


Leu Thr Lys Ala Ile Gly Tyr Glu Ser Glu Lys Leu Ile Pro Glu Ser 
        275                 280                 285             


Gly Phe Cys Pro Tyr Leu Lys Asp Glu Lys Arg Leu Pro Ala Ser His 
    290                 295                 300                 


Lys Leu Asn Glu Glu Arg Arg Leu Trp Glu Thr Leu Asn Asn Ala Arg 
305                 310                 315                 320 


Tyr Ser Asp Pro Ile Val Asp Ile Val Thr Gly Glu Ile Thr Gly Tyr 
                325                 330                 335     


Tyr Glu Lys Gln Phe Thr Lys Glu Gln Lys Gln Lys Leu Phe Asp Tyr 
            340                 345                 350         


Leu Leu Thr Gly Ser Glu Leu Thr Pro Ala Gln Thr Lys Lys Leu Leu 
        355                 360                 365             


Gly Leu Lys Asn Thr Asn Phe Glu Asp Ile Ile Leu Gln Gly Arg Asp 
    370                 375                 380                 


Lys Lys Ala Gln Lys Ile Lys Gly Tyr Lys Leu Ile Lys Leu Glu Ser 
385                 390                 395                 400 


Met Pro Phe Trp Ala Arg Leu Ser Glu Ala Gln Gln Asp Ser Phe Leu 
                405                 410                 415     


Tyr Asp Trp Asn Ser Cys Pro Asp Glu Lys Leu Leu Thr Glu Lys Leu 
            420                 425                 430         


Ser Asn Glu Tyr His Leu Thr Glu Glu Glu Ile Asp Asn Ala Phe Asn 
        435                 440                 445             


Glu Ile Val Leu Ser Ser Ser Tyr Ala Pro Leu Gly Lys Ser Ala Met 
    450                 455                 460                 


Leu Ile Ile Leu Glu Lys Ile Lys Asn Asp Leu Ser Tyr Thr Glu Ala 
465                 470                 475                 480 


Val Glu Glu Ala Leu Lys Glu Gly Lys Leu Thr Lys Glu Lys Gln Ala 
                485                 490                 495     


Ile Lys Asp Arg Leu Pro Tyr Tyr Gly Ala Val Leu Gln Glu Ser Thr 
            500                 505                 510         


Gln Lys Ile Ile Ala Lys Gly Phe Ser Pro Gln Phe Lys Asp Lys Gly 
        515                 520                 525             


Tyr Lys Thr Pro His Thr Asn Lys Tyr Glu Leu Glu Tyr Gly Arg Ile 
    530                 535                 540                 


Ala Asn Pro Val Val His Gln Thr Leu Asn Glu Leu Arg Lys Leu Val 
545                 550                 555                 560 


Asn Glu Ile Ile Asp Ile Leu Gly Lys Lys Pro Cys Glu Ile Gly Leu 
                565                 570                 575     


Glu Thr Ala Arg Glu Leu Lys Lys Ser Ala Glu Asp Arg Ser Lys Leu 
            580                 585                 590         


Ser Arg Glu Gln Asn Asp Asn Glu Ser Asn Arg Asn Arg Ile Tyr Glu 
        595                 600                 605             


Ile Tyr Ile Arg Pro Gln Gln Gln Val Ile Ile Thr Arg Arg Glu Asn 
    610                 615                 620                 


Pro Arg Asn Tyr Ile Leu Lys Phe Glu Leu Leu Glu Glu Gln Lys Ser 
625                 630                 635                 640 


Gln Cys Pro Phe Cys Gly Gly Gln Ile Ser Pro Asn Asp Ile Ile Asn 
                645                 650                 655     


Asn Gln Ala Asp Ile Glu His Leu Phe Pro Ile Ala Glu Ser Glu Asp 
            660                 665                 670         


Asn Gly Arg Asn Asn Leu Val Ile Ser His Ser Ala Cys Asn Ala Asp 
        675                 680                 685             


Lys Ala Lys Arg Ser Pro Trp Ala Ala Phe Ala Ser Ala Ala Lys Asp 
    690                 695                 700                 


Ser Lys Tyr Asp Tyr Asn Arg Ile Leu Ser Asn Val Lys Glu Asn Ile 
705                 710                 715                 720 


Pro His Lys Ala Trp Arg Phe Asn Gln Gly Ala Phe Glu Lys Phe Ile 
                725                 730                 735     


Glu Asn Lys Pro Met Ala Ala Arg Phe Lys Thr Asp Asn Ser Tyr Ile 
            740                 745                 750         


Ser Lys Val Ala His Lys Tyr Leu Ala Cys Leu Phe Glu Lys Pro Asn 
        755                 760                 765             


Ile Ile Cys Val Lys Gly Ser Leu Thr Ala Gln Leu Arg Met Ala Trp 
    770                 775                 780                 


Gly Leu Gln Gly Leu Met Ile Pro Phe Ala Lys Gln Leu Ile Thr Glu 
785                 790                 795                 800 


Lys Glu Ser Glu Ser Phe Asn Lys Asp Val Asn Ser Asn Lys Lys Ile 
                805                 810                 815     


Arg Leu Asp Asn Arg His His Ala Leu Asp Ala Ile Val Ile Ala Tyr 
            820                 825                 830         


Ala Ser Arg Gly Tyr Gly Asn Leu Leu Asn Lys Met Ala Gly Lys Asp 
        835                 840                 845             


Tyr Lys Ile Asn Tyr Ser Glu Arg Asn Trp Leu Ser Lys Ile Leu Leu 
    850                 855                 860                 


Pro Pro Asn Asn Ile Val Trp Glu Asn Ile Asp Ala Asp Leu Glu Ser 
865                 870                 875                 880 


Phe Glu Ser Ser Val Lys Thr Ala Leu Lys Asn Ala Phe Ile Ser Val 
                885                 890                 895     


Lys His Asp His Ser Asp Asn Gly Glu Leu Val Lys Gly Thr Met Tyr 
            900                 905                 910         


Lys Ile Phe Tyr Ser Glu Arg Gly Tyr Thr Leu Thr Thr Tyr Lys Lys 
        915                 920                 925             


Leu Ser Ala Leu Lys Leu Thr Asp Pro Gln Lys Lys Lys Thr Pro Lys 
    930                 935                 940                 


Asp Phe Leu Glu Thr Ala Leu Leu Lys Phe Lys Gly Arg Glu Ser Glu 
945                 950                 955                 960 


Met Lys Asn Glu Lys Ile Lys Ser Ala Ile Glu Asn Asn Lys Arg Leu 
                965                 970                 975     


Phe Asp Val Ile Gln Asp Asn Leu Glu Lys Ala Lys Lys Leu Leu Glu 
            980                 985                 990         


Glu Glu Asn Glu Lys Ser Lys Ala  Glu Gly Lys Lys Glu  Lys Asn Ile 
        995                 1000                 1005             


Asn Asp  Ala Ser Ile Tyr Gln  Lys Ala Ile Ser Leu  Ser Gly Asp 
    1010                 1015                 1020             


Lys Tyr  Val Gln Leu Ser Lys  Lys Glu Pro Gly Lys  Phe Phe Ala 
    1025                 1030                 1035             


Ile Ser  Lys Pro Thr Pro Thr  Thr Thr Gly Tyr Gly  Tyr Asp Thr 
    1040                 1045                 1050             


Gly Asp  Ser Leu Cys Val Asp  Leu Tyr Tyr Asp Asn  Lys Gly Lys 
    1055                 1060                 1065             


Leu Cys  Gly Glu Ile Ile Arg  Lys Ile Asp Ala Gln  Gln Lys Asn 
    1070                 1075                 1080             


Pro Leu  Lys Tyr Lys Glu Gln  Gly Phe Thr Leu Phe  Glu Arg Ile 
    1085                 1090                 1095             


Tyr Gly  Gly Asp Ile Leu Glu  Val Asp Phe Asp Ile  His Ser Asp 
    1100                 1105                 1110             


Lys Asn  Ser Phe Arg Asn Asn  Thr Gly Ser Ala Pro  Glu Asn Arg 
    1115                 1120                 1125             


Val Phe  Ile Lys Val Gly Thr  Phe Thr Glu Ile Thr  Asn Asn Asn 
    1130                 1135                 1140             


Ile Gln  Ile Trp Phe Gly Asn  Ile Ile Lys Ser Thr  Gly Gly Gln 
    1145                 1150                 1155             


Asp Asp  Ser Phe Thr Ile Asn  Ser Met Gln Gln Tyr  Asn Pro Arg 
    1160                 1165                 1170             


Lys Leu  Ile Leu Ser Ser Cys  Gly Phe Ile Lys Tyr  Arg Ser Pro 
    1175                 1180                 1185             


Ile Leu  Lys Asn Lys Glu Gly  
    1190                 1195 


<210>  29
<211>  1114
<212>  PRT
<213>  Eubacterium rectal

<400>  29

Met Asn Tyr Thr Glu Lys Glu Lys Leu Phe Met Lys Tyr Ile Leu Ala 
1               5                   10                  15      


Leu Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Ile Leu Asp Lys Glu 
            20                  25                  30          


Ser Glu Thr Val Ile Glu Ala Gly Ser Asn Ile Phe Pro Glu Ala Ser 
        35                  40                  45              


Ala Ala Asp Asn Gln Leu Arg Arg Asp Met Arg Gly Ala Lys Arg Asn 
    50                  55                  60                  


Asn Arg Arg Leu Lys Thr Arg Ile Asn Asp Phe Ile Lys Leu Trp Glu 
65                  70                  75                  80  


Asn Asn Asn Leu Ser Ile Pro Gln Phe Lys Ser Thr Glu Ile Val Gly 
                85                  90                  95      


Leu Lys Val Arg Ala Ile Thr Glu Glu Ile Thr Leu Asp Glu Leu Tyr 
            100                 105                 110         


Leu Ile Leu Tyr Ser Tyr Leu Lys His Arg Gly Ile Ser Tyr Leu Glu 
        115                 120                 125             


Asp Ala Leu Asp Asp Thr Val Ser Gly Ser Ser Ala Tyr Ala Asn Gly 
    130                 135                 140                 


Leu Lys Leu Asn Ala Lys Glu Leu Glu Thr His Tyr Pro Cys Glu Ile 
145                 150                 155                 160 


Gln Gln Glu Arg Leu Asn Thr Ile Gly Lys Tyr Arg Gly Gln Ser Gln 
                165                 170                 175     


Ile Ile Asn Glu Asn Gly Glu Val Leu Asp Leu Ser Asn Val Phe Thr 
            180                 185                 190         


Ile Gly Ala Tyr Arg Lys Glu Ile Gln Arg Val Phe Glu Ile Gln Lys 
        195                 200                 205             


Lys Tyr His Pro Glu Leu Thr Asp Glu Phe Cys Asp Gly Tyr Met Leu 
    210                 215                 220                 


Ile Phe Asn Arg Lys Arg Lys Tyr Tyr Glu Gly Pro Gly Asn Glu Lys 
225                 230                 235                 240 


Ser Arg Thr Asp Tyr Gly Arg Phe Thr Thr Lys Leu Asp Ala Asn Gly 
                245                 250                 255     


Asn Tyr Ile Thr Glu Asp Asn Ile Phe Glu Lys Leu Ile Gly Lys Cys 
            260                 265                 270         


Ser Val Tyr Pro Asp Glu Leu Arg Ala Ala Ala Ala Ser Tyr Thr Ala 
        275                 280                 285             


Gln Glu Tyr Asn Val Leu Asn Asp Leu Asn Asn Leu Thr Ile Asn Gly 
    290                 295                 300                 


Arg Lys Leu Glu Glu Asn Glu Lys His Glu Ile Val Glu Arg Ile Lys 
305                 310                 315                 320 


Ser Ser Asn Thr Ile Asn Met Arg Lys Ile Ile Ser Asp Cys Met Gly 
                325                 330                 335     


Glu Asn Ile Asp Asp Phe Ala Gly Ala Arg Ile Asp Lys Ser Gly Lys 
            340                 345                 350         


Glu Ile Phe His Lys Phe Glu Val Tyr Asn Lys Met Arg Lys Ala Leu 
        355                 360                 365             


Leu Glu Ile Gly Ile Asp Ile Ser Asn Tyr Ser Arg Glu Glu Leu Asp 
    370                 375                 380                 


Glu Ile Gly Tyr Ile Met Thr Ile Asn Thr Asp Lys Glu Ala Met Met 
385                 390                 395                 400 


Glu Ala Phe Gln Lys Ser Trp Ile Asp Leu Ser Asp Asp Val Lys Gln 
                405                 410                 415     


Cys Leu Ile Asn Met Arg Lys Thr Asn Gly Ala Leu Phe Asn Lys Trp 
            420                 425                 430         


Gln Ser Phe Ser Leu Lys Ile Met Asn Glu Leu Ile Pro Glu Met Tyr 
        435                 440                 445             


Ala Gln Pro Lys Glu Gln Met Thr Leu Leu Thr Glu Met Gly Val Thr 
    450                 455                 460                 


Lys Gly Thr Gln Glu Glu Phe Ala Gly Leu Lys Tyr Ile Pro Val Asp 
465                 470                 475                 480 


Val Val Ser Glu Asp Ile Phe Asn Pro Val Val Arg Arg Ser Val Arg 
                485                 490                 495     


Ile Ser Phe Lys Ile Leu Asn Ala Val Leu Lys Lys Tyr Lys Ala Leu 
            500                 505                 510         


Asp Thr Ile Val Ile Glu Met Pro Arg Asp Arg Asn Ser Glu Glu Gln 
        515                 520                 525             


Lys Lys Arg Ile Asn Asp Ser Gln Lys Leu Asn Glu Lys Glu Met Glu 
    530                 535                 540                 


Tyr Ile Glu Lys Lys Leu Ala Val Thr Tyr Gly Ile Lys Leu Ser Pro 
545                 550                 555                 560 


Ser Asp Phe Ser Ser Gln Lys Gln Leu Ser Leu Lys Leu Lys Leu Trp 
                565                 570                 575     


Asn Glu Gln Asp Gly Ile Cys Leu Tyr Ser Gly Lys Thr Ile Asp Pro 
            580                 585                 590         


Asn Asp Ile Ile Asn Asn Pro Gln Leu Phe Glu Ile Asp His Ile Ile 
        595                 600                 605             


Pro Arg Ser Ile Ser Phe Asp Asp Ala Arg Ser Asn Lys Val Leu Val 
    610                 615                 620                 


Tyr Arg Ser Glu Asn Gln Lys Lys Gly Asn Gln Thr Pro Tyr Tyr Tyr 
625                 630                 635                 640 


Leu Thr His Ser His Ser Glu Trp Ser Phe Glu Gln Tyr Lys Ala Thr 
                645                 650                 655     


Val Met Asn Leu Ser Lys Lys Lys Glu Tyr Ala Ile Ser Arg Lys Lys 
            660                 665                 670         


Ile Gln Asn Leu Leu Tyr Ser Glu Asp Ile Thr Lys Met Asp Val Leu 
        675                 680                 685             


Lys Gly Phe Ile Asn Arg Asn Ile Asn Asp Thr Ser Tyr Ala Ser Arg 
    690                 695                 700                 


Leu Val Leu Asn Thr Ile Gln Asn Phe Phe Met Ala Asn Glu Ala Asp 
705                 710                 715                 720 


Thr Lys Val Lys Val Ile Lys Gly Ser Tyr Thr His Gln Met Arg Cys 
                725                 730                 735     


Asn Leu Lys Leu Asp Lys Asn Arg Asp Glu Ser Tyr Ser His His Ala 
            740                 745                 750         


Val Asp Ala Met Leu Ile Gly Tyr Ser Glu Leu Gly Tyr Glu Ala Tyr 
        755                 760                 765             


His Lys Leu Gln Gly Glu Phe Ile Asp Phe Glu Thr Gly Glu Ile Leu 
    770                 775                 780                 


Arg Lys Asp Met Trp Asp Glu Asn Met Ser Asp Glu Val Tyr Ala Asp 
785                 790                 795                 800 


Tyr Leu Tyr Gly Lys Lys Trp Ala Asn Ile Arg Asn Glu Val Val Lys 
                805                 810                 815     


Ala Glu Lys Asn Val Lys Tyr Trp His Tyr Val Met Arg Lys Ser Asn 
            820                 825                 830         


Arg Gly Leu Cys Asn Gln Thr Ile Arg Gly Thr Arg Glu Tyr Asp Gly 
        835                 840                 845             


Lys Gln Tyr Lys Ile Asn Lys Leu Asp Ile Arg Thr Lys Glu Gly Ile 
    850                 855                 860                 


Lys Val Phe Ala Lys Leu Ala Phe Ser Lys Lys Asp Ser Asp Arg Glu 
865                 870                 875                 880 


Arg Leu Leu Val Tyr Leu Asn Asp Arg Arg Thr Phe Asp Asp Leu Cys 
                885                 890                 895     


Lys Ile Tyr Glu Asp Tyr Ser Asp Ala Ala Asn Pro Phe Val Gln Tyr 
            900                 905                 910         


Glu Lys Glu Thr Gly Asp Ile Ile Arg Lys Tyr Ser Lys Lys His Asn 
        915                 920                 925             


Gly Pro Arg Ile Asp Lys Leu Lys Tyr Lys Asp Gly Glu Val Gly Ala 
    930                 935                 940                 


Cys Ile Asp Ile Ser His Lys Tyr Gly Phe Glu Lys Gly Ser Lys Lys 
945                 950                 955                 960 


Val Ile Leu Glu Ser Leu Val Pro Tyr Arg Met Asp Val Tyr Tyr Lys 
                965                 970                 975     


Glu Glu Asn His Ser Tyr Tyr Leu Val Gly Val Lys Gln Ser Asp Ile 
            980                 985                 990         


Lys Phe Glu Lys Gly Arg Asn Val  Ile Asp Glu Glu Ala  Tyr Ala Arg 
        995                 1000                 1005             


Ile Leu  Val Asn Glu Lys Met  Ile Gln Pro Gly Gln  Ser Arg Ala 
    1010                 1015                 1020             


Asp Leu  Glu Asn Leu Gly Phe  Lys Phe Lys Leu Ser  Phe Tyr Lys 
    1025                 1030                 1035             


Asn Asp  Ile Ile Glu Tyr Glu  Lys Asp Gly Lys Ile  Tyr Thr Glu 
    1040                 1045                 1050             


Arg Leu  Val Ser Arg Thr Met  Pro Lys Gln Arg Asn  Tyr Ile Glu 
    1055                 1060                 1065             


Thr Lys  Pro Ile Asp Lys Ala  Lys Phe Glu Lys Gln  Asn Leu Val 
    1070                 1075                 1080             


Gly Leu  Gly Lys Thr Lys Phe  Ile Lys Lys Tyr Arg  Tyr Asp Ile 
    1085                 1090                 1095             


Leu Gly  Asn Lys Tyr Ser Cys  Ser Glu Glu Lys Phe  Thr Ser Phe 
    1100                 1105                 1110             


Cys 
    


<210>  30
<211>  1512
<212>  PRT
<213>  Fibrobacter succinogenes

<400>  30

Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Ala Asp Glu Ile Thr Arg Asp Asp Gly Ser Arg Tyr 
            20                  25                  30          


Leu Lys Pro Asn Gly Ile Ser Ala Ala Gly Ser Arg Ile Ile Pro Met 
        35                  40                  45              


Ser Ala Asp Ile Leu Gly Asp Phe Glu Lys Gly Asn Ser Ile Ser Gln 
    50                  55                  60                  


Thr Ala Glu Arg Thr Arg Met Arg Met Ala Arg Arg Leu His Glu Arg 
65                  70                  75                  80  


Ala Leu Leu Arg Arg Glu Arg Leu Leu Arg Val Leu Asn Leu Leu Asp 
                85                  90                  95      


Phe Leu Pro Lys His Phe Ala Asp Lys Ile Asp Arg Tyr Gly Lys Phe 
            100                 105                 110         


Thr Asp Asp Ser Glu Pro Lys Leu Ala Trp Arg Lys Asn Thr Glu Gly 
        115                 120                 125             


Lys Tyr Glu Phe Ile Phe Gln Asp Ala Phe Asn Glu Met Leu Ala Glu 
    130                 135                 140                 


Phe Lys Asp Lys Gln Pro Glu Ile Val Glu Glu Gly Lys Lys Ile Pro 
145                 150                 155                 160 


Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Glu Lys Ala 
                165                 170                 175     


Leu Ser Lys Glu Glu Leu Ser Trp Ile Leu Leu Gln Phe Asn Gln Lys 
            180                 185                 190         


Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Ile Pro Gln Asp 
        195                 200                 205             


Lys Lys Ile Glu Tyr Leu Ala Gln Lys Val Val Lys Val Glu Ala Thr 
    210                 215                 220                 


Asp Gln Lys Lys Gly Asp Asp Val Trp Tyr Asn Val Tyr Leu Glu Asn 
225                 230                 235                 240 


Gly Met Ile Tyr Arg Arg Thr Ser Lys Ala Pro Leu Asp Trp Glu Gly 
                245                 250                 255     


Lys Val Lys Glu Phe Ile Val Thr Thr Glu Val Glu Asn Asp Gly Glu 
            260                 265                 270         


Thr Pro Lys Lys Asp Lys Glu Gly Asn Ile Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Lys Glu Asp Asp Trp Thr Leu Leu Lys Lys Lys Thr Glu Ala Asp 
    290                 295                 300                 


Ile Glu Asn Ser His Lys Thr Val Gly Cys Tyr Ile Tyr Asp Ser Leu 
305                 310                 315                 320 


Leu Asn Asn Pro Lys Gln Lys Ile Ile Gly Lys Leu Val Arg Thr Val 
                325                 330                 335     


Glu Arg Lys Phe Tyr Lys Glu Glu Leu Thr Gln Ile Leu Lys Lys Gln 
            340                 345                 350         


Val Glu Leu Ile Pro Glu Leu Arg Asp Asp Asn Leu Tyr Lys Gln Cys 
        355                 360                 365             


Ile Glu Glu Leu Tyr Pro Ile Asn Glu Ala His Arg Asn Thr Ile Ala 
    370                 375                 380                 


Lys Thr Asp Phe Ala Asn Leu Phe Ile Asn Asp Ile Leu Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ser Gln Ile Asp Asn Cys Pro Tyr Glu 
                405                 410                 415     


Glu Arg Ile Phe Ile Asp Ser Lys Thr Gly Glu Lys Lys Lys Val Pro 
            420                 425                 430         


Val Lys Cys Ile Ala Lys Ser Asn Pro Leu Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Ile Gln Asn Leu Arg Ile Tyr Gln Arg Glu Lys Glu Ile 
    450                 455                 460                 


Asp Gly Lys Leu Leu Thr Asp Ile Asp Ile Thr Ser Glu Cys Leu Lys 
465                 470                 475                 480 


Ser Glu Glu Asp Tyr Val Arg Leu Phe Asp Trp Leu Asn Asp Arg Glu 
                485                 490                 495     


Thr Ile Glu Gln Glu Asp Leu Leu Lys His Leu Phe Asn Thr Lys Lys 
            500                 505                 510         


Ser Lys Asn Lys Glu Asn Pro Tyr Arg Trp Asn Tyr Val Glu Asp Lys 
        515                 520                 525             


Val Tyr Pro Cys Asn Glu Thr Arg Ala Thr Ile Leu Lys Gly Phe Ser 
    530                 535                 540                 


Lys Cys Gly Ile Asn Ala Ser Val Leu Ser Pro Glu Leu Glu Met Ala 
545                 550                 555                 560 


Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Lys Glu Ile Glu Thr 
                565                 570                 575     


Ala Leu Thr His Phe Ala Gln Lys Gln Gly Trp Asn Asp Asp Phe Ala 
            580                 585                 590         


Lys Val Phe Ser Lys Ala Lys Pro Phe Lys Lys Asp Tyr Gly Ser Tyr 
        595                 600                 605             


Ser Glu Lys Ala Ile Lys Lys Leu Leu Ser Leu Met Arg Met Gly Lys 
    610                 615                 620                 


Tyr Trp Asn Gln Asp Asn Ile Asp Lys Asn Thr Leu Asp Arg Ile Asp 
625                 630                 635                 640 


Lys Ile Ile Asn Gly Glu Tyr Asp Glu Lys Ile Ser Asn Arg Val Arg 
                645                 650                 655     


Asp Asn Ala Ile Asn Leu Lys Asp Ile Ser Asp Phe Arg Gly Leu Pro 
            660                 665                 670         


Val Trp Leu Ala Cys Tyr Ile Val Tyr Asp Arg His Ser Glu Ala Lys 
        675                 680                 685             


Asp Cys Thr Lys Trp Asn Ser Pro Glu Glu Ile Asp Ser Tyr Leu Lys 
    690                 695                 700                 


Lys Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val 
705                 710                 715                 720 


Thr Glu Thr Leu Arg Thr Val Arg Asp Ile Trp Ile Gln Glu Glu Gln 
                725                 730                 735     


Ile Asp Glu Ile His Leu Glu Leu Gly Arg Asp Leu Lys Asn Pro Ala 
            740                 745                 750         


Asp Lys Arg Lys Lys Met Ser Glu Asn Ile Leu Lys Asn Glu Asn Thr 
        755                 760                 765             


Asn Leu Arg Ile Lys Ala Met Leu Met Glu Phe Met Asn Pro Ser Met 
    770                 775                 780                 


Gly Ile Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln Asp Ile Leu 
785                 790                 795                 800 


Arg Ile Tyr Glu Glu Asn Ala Leu Asp Asn Leu Thr Lys Asp Asp Lys 
                805                 810                 815     


Asp Phe Asp Phe Ile Ser Lys Ile Ser Lys Gln Ala Gln Pro Ser Lys 
            820                 825                 830         


Thr Asp Ile Ile Arg Tyr Lys Cys Trp Leu Glu Gln Lys Tyr Arg Ser 
        835                 840                 845             


Pro Tyr Thr Gly Lys Thr Ile Ser Leu Ser Lys Leu Phe Thr Pro Ala 
    850                 855                 860                 


Tyr Glu Ile Glu His Val Ile Pro Gln Ser Leu Tyr Phe Asp Asp Ser 
865                 870                 875                 880 


Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Lys Leu Lys Asp 
                885                 890                 895     


Arg Gln Leu Gly Tyr Lys Phe Ile Ala Glu His His Gly Glu Lys Val 
            900                 905                 910         


Gln Leu Ser Gln Gly Glu Val Val Glu Ile Leu Ser Val Asp Ala Tyr 
        915                 920                 925             


Glu Lys Phe Val Lys Glu Asn Tyr Ala Asn Asn Arg Ile Lys Met Lys 
    930                 935                 940                 


Lys Leu Leu Met Glu Ser Ile Pro Asp Glu Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Gly Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Lys Ile Asp Asp Glu Asn Tyr Glu Pro Glu Ala Val 
            980                 985                 990         


Ser Lys Asn Leu Ile Ser Cys Asn  Gly Ala Ile Thr Asp  Arg Leu Lys 
        995                 1000                 1005             


Lys Asp  Trp Gly Met Asn Asp  Val Trp Asn Ser Ile  Ile Leu Pro 
    1010                 1015                 1020             


Arg Phe  Ile Arg Met Asn Gln  Ile Thr Gly Lys Asp  Cys Phe Thr 
    1025                 1030                 1035             


Thr Thr  Asn Ala Glu Gly His  Leu Ile Pro Gln Met  Pro Leu Glu 
    1040                 1045                 1050             


Leu Gln  Lys Gly Phe Asn Lys  Lys Arg Ile Asp His  Arg His His 
    1055                 1060                 1065             


Ala Met  Asp Ala Ile Val Ile  Ala Cys Thr Thr Arg  Asp His Val 
    1070                 1075                 1080             


Asn Leu  Leu Asn Asn Glu Ala  Ala His Ser Lys Phe  Asn Ala Thr 
    1085                 1090                 1095             


Arg Tyr  Gln Leu Gln Arg Lys  Leu Arg Arg Phe Glu  Lys Ala Val 
    1100                 1105                 1110             


Ile Asp  Gly Lys Glu Arg Glu  Val Ala Lys Glu Phe  Leu Lys Pro 
    1115                 1120                 1125             


Trp Asp  Ser Phe Ser Ser Asp  Ser Lys Asn Ile Leu  Glu Asn Ile 
    1130                 1135                 1140             


Ile Val  Ser Phe Lys Gln Asn  Gln Arg Val Ile Asn  Lys Thr Thr 
    1145                 1150                 1155             


Asn Ala  Phe Leu His Phe Asp  Glu Asn Gly Lys Lys  Thr Phe Ile 
    1160                 1165                 1170             


Lys Gln  Gly Lys Gly Asp Ser  Trp Ala Ile Arg Lys  Ser Met His 
    1175                 1180                 1185             


Lys Asp  Thr Val Phe Gly Glu  Ile Asn Leu Arg Lys  Val Arg Ser 
    1190                 1195                 1200             


Val Ser  Leu Asn Glu Ala Ile  Lys Val Pro Glu Arg  Val Leu Asn 
    1205                 1210                 1215             


Lys Lys  Ile Lys Glu Lys Ile  Leu Glu Leu Lys Asn  Asn Lys Ile 
    1220                 1225                 1230             


Asp Ala  Lys Asn Ile Lys Lys  Tyr Ile Glu Glu Asn  His Thr Gly 
    1235                 1240                 1245             


Gly Tyr  Gly Ile Asp Ser Ser  Lys Ile Asp Val Phe  Tyr Phe Thr 
    1250                 1255                 1260             


Lys Glu  Thr Lys Glu Arg Phe  Phe Ala Thr Arg Lys  Thr Leu Asp 
    1265                 1270                 1275             


Thr Ser  Phe Asn Gln Ala Lys  Ile Lys Asp Ser Ile  Ala Asp Ser 
    1280                 1285                 1290             


Gly Ile  Gln Lys Ile Leu Leu  Ala His Leu Lys Ser  Lys Asn Gly 
    1295                 1300                 1305             


Asp Ala  Glu Gln Ala Phe Ser  Pro Asp Gly Ile Asp  Glu Met Asn 
    1310                 1315                 1320             


Lys Asn  Ile Val Glu Leu Asn  Asn Gly Lys Phe His  Gln Pro Ile 
    1325                 1330                 1335             


Leu Lys  Val Arg Val Tyr Glu  Lys Ala Asp Lys Phe  Ala Val Gly 
    1340                 1345                 1350             


Gln Lys  Gly Asn Lys Lys Val  Lys Phe Val Glu Ala  Ala Lys Gly 
    1355                 1360                 1365             


Thr Asn  Leu Phe Phe Ala Ile  Phe Glu Lys Asp Gly  Lys Arg Ser 
    1370                 1375                 1380             


Tyr Leu  Thr Ile Pro Leu Asn  Val Met Ile Asp Cys  Gln Lys Gln 
    1385                 1390                 1395             


Tyr Gly  Asn Gln Trp Lys Asn  Asn Ile Glu Ala Tyr  Leu Lys Glu 
    1400                 1405                 1410             


Lys Glu  Leu Val Glu Lys Asp  Val Lys Leu Gln Phe  Ile Leu Ser 
    1415                 1420                 1425             


Pro Asn  Asp Leu Val Tyr Leu  Pro Thr Glu Gly Ser  Ile Asp Lys 
    1430                 1435                 1440             


Lys Arg  Ile Tyr Lys Val Val  Ser Phe Thr Asn Asn  Arg Leu Tyr 
    1445                 1450                 1455             


Ala Ile  Pro Tyr Ala Ile Ala  Lys Ser Ile Val Asp  Lys Asn Glu 
    1460                 1465                 1470             


Phe Thr  Gln Leu Asn Lys Ile  Glu Phe Thr Asp Asn  Lys Glu Ser 
    1475                 1480                 1485             


Ile Lys  Asp Ala Cys Val Pro  Val Ile Ile Asp Arg  Leu Gly Asn 
    1490                 1495                 1500             


Val Ile  Glu Phe Asn Gly Lys  Arg Leu 
    1505                 1510         


<210>  31
<211>  1347
<212>  PRT
<213>  Finegoldia magna

<400>  31

Met Lys Ser Glu Lys Lys Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Phe Tyr Asn Ile Leu Arg Ala 
            20                  25                  30          


Lys Gly Lys Asp Leu Trp Gly Val Arg Leu Phe Glu Lys Ala Asp Thr 
        35                  40                  45              


Ala Ala Asn Thr Arg Ile Phe Arg Ser Gly Arg Arg Arg Asn Asp Arg 
    50                  55                  60                  


Lys Gly Met Arg Leu Gln Ile Leu Arg Glu Ile Phe Glu Asp Glu Ile 
65                  70                  75                  80  


Lys Lys Val Asp Lys Asp Phe Tyr Asp Arg Leu Asp Glu Ser Lys Phe 
                85                  90                  95      


Trp Ala Glu Asp Lys Lys Val Ser Gly Lys Tyr Ser Leu Phe Asn Asp 
            100                 105                 110         


Lys Asn Phe Ser Asp Lys Gln Tyr Phe Glu Lys Phe Pro Thr Ile Phe 
        115                 120                 125             


His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 
    130                 135                 140                 


Tyr Tyr Phe Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe 
145                 150                 155                 160 


Leu Ile Asp Gly Gln Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 
                165                 170                 175     


Glu Gln Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 
            180                 185                 190         


Glu Glu Leu Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 
        195                 200                 205             


Lys Arg Thr Asp Lys Lys Asn Asn Leu Lys Glu Leu Ile Lys Gly Gln 
    210                 215                 220                 


Asp Phe Asn Lys Gln Glu Gly Asn Ile Leu Asn Ser Ile Phe Glu Ser 
225                 230                 235                 240 


Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 
                245                 250                 255     


Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 
            260                 265                 270         


Gly Asp Ser Tyr Glu Glu Asn Leu Gln Tyr Phe Glu Glu Val Leu Gln 
        275                 280                 285             


Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Thr Tyr Asp Phe Leu 
    290                 295                 300                 


Ile Leu Gln Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 
                325                 330                 335     


Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gln Val Phe 
            340                 345                 350         


Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 
        355                 360                 365             


Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 
    370                 375                 380                 


Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gln Cys Asp Cys Glu 
385                 390                 395                 400 


Asp Glu Asp Val Lys Tyr Leu Leu Gly Lys Ile Glu Gln Glu Asn Phe 
                405                 410                 415     


Leu Leu Lys Gln Ile Ser Ser Ile Asn Ser Val Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Asn Tyr 
        435                 440                 445             


Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 
    450                 455                 460                 


Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 
465                 470                 475                 480 


Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 
                485                 490                 495     


Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 
            500                 505                 510         


Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gln Cys Thr Tyr 
        515                 520                 525             


Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn Gly Lys Pro 
545                 550                 555                 560 


Leu Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Val Arg Asn 
            580                 585                 590         


Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 
        595                 600                 605             


Ile Ala Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Glu 
    610                 615                 620                 


Asp Lys Phe Asp Val Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 
625                 630                 635                 640 


Ile His Thr Gly Asn Lys Lys Leu Leu Lys Lys Tyr Ile Glu Glu Thr 
                645                 650                 655     


Tyr Pro Asp Leu Ser Ser Ser Gln Ile Gln Lys Ile Ile Asn Leu Lys 
            660                 665                 670         


Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Lys 
        675                 680                 685             


Gly Thr Lys Lys Glu Thr Glu Lys Thr Asp Thr Val Ile Asn Phe Leu 
    690                 695                 700                 


Arg Asn Ser Ser Asp Asn Leu Met Gln Ile Ile Gly Ser Gln Asn Tyr 
705                 710                 715                 720 


Ser Phe Asn Glu Tyr Ile Asp Lys Leu Arg Lys Lys Tyr Ile Pro Gln 
                725                 730                 735     


Glu Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val 
            740                 745                 750         


Lys Lys Met Ile Trp Gln Val Ile Arg Val Thr Glu Glu Ile Thr Lys 
        755                 760                 765             


Val Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser 
    770                 775                 780                 


Glu Glu Glu Lys Lys Thr Thr Ile Ser Arg Lys Lys Leu Leu Asp Leu 
785                 790                 795                 800 


Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gln Tyr Glu Lys Leu 
                805                 810                 815     


Leu Thr Gly Leu Asn Lys Leu Asp Asp Ser Asp Leu Arg Ser Arg Lys 
            820                 825                 830         


Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Asp Met Tyr Thr Gly Glu 
        835                 840                 845             


Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys Asp 
    850                 855                 860                 


His Ile Ile Pro Gln Ser Met Lys Lys Asp Asp Ser Ile Ile Asn Asn 
865                 870                 875                 880 


Leu Val Leu Val Asn Lys Asn Ala Asn Gln Thr Thr Lys Gly Asn Ile 
                885                 890                 895     


Tyr Pro Val Pro Ser Ser Ile Arg Asn Asn Pro Lys Ile Tyr Asn Tyr 
            900                 905                 910         


Trp Lys Tyr Leu Met Glu Lys Glu Phe Ile Ser Lys Glu Lys Tyr Asn 
        915                 920                 925             


Arg Leu Ile Arg Asn Thr Pro Leu Thr Asn Glu Glu Leu Gly Gly Phe 
    930                 935                 940                 


Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr Lys Ala Ile Lys 
945                 950                 955                 960 


Glu Leu Phe Glu Lys Phe Tyr Gln Lys Ser Lys Ile Ile Pro Val Lys 
                965                 970                 975     


Ala Ser Leu Ala Ser Asp Leu Arg Lys Asp Met Asn Thr Leu Lys Ser 
            980                 985                 990         


Arg Glu Val Asn Asp Leu His His  Ala His Asp Ala Phe  Leu Asn Ile 
        995                 1000                 1005             


Val Ala  Gly Asp Val Trp Asn  Arg Glu Phe Thr Ser  Asn Pro Ile 
    1010                 1015                 1020             


Asn Tyr  Val Lys Glu Asn Arg  Glu Gly Asp Lys Val  Lys Tyr Ser 
    1025                 1030                 1035             


Leu Ser  Lys Asp Phe Thr Arg  Pro Arg Lys Ser Lys  Gly Lys Val 
    1040                 1045                 1050             


Ile Trp  Thr Pro Glu Lys Gly  Arg Lys Leu Ile Val  Asp Thr Leu 
    1055                 1060                 1065             


Asn Lys  Pro Ser Val Leu Ile  Ser Asn Glu Ser His  Val Lys Lys 
    1070                 1075                 1080             


Gly Glu  Leu Phe Asn Ala Thr  Ile Ala Gly Lys Lys  Asp Tyr Lys 
    1085                 1090                 1095             


Lys Gly  Lys Ile Tyr Leu Pro  Leu Lys Lys Asp Asp  Arg Leu Gln 
    1100                 1105                 1110             


Asp Val  Ser Lys Tyr Gly Gly  Tyr Lys Ala Ile Asn  Gly Ala Phe 
    1115                 1120                 1125             


Phe Phe  Leu Val Glu His Thr  Lys Ser Lys Lys Arg  Ile Arg Ser 
    1130                 1135                 1140             


Ile Glu  Leu Phe Pro Leu His  Leu Leu Ser Lys Phe  Tyr Glu Asp 
    1145                 1150                 1155             


Lys Asn  Thr Val Leu Asp Tyr  Ala Ile Asn Val Leu  Gln Leu Gln 
    1160                 1165                 1170             


Asp Pro  Lys Ile Ile Ile Asp  Lys Ile Asn Tyr Arg  Thr Glu Ile 
    1175                 1180                 1185             


Ile Ile  Asp Asn Phe Ser Tyr  Leu Ile Ser Thr Lys  Ser Asn Asp 
    1190                 1195                 1200             


Gly Ser  Ile Thr Val Lys Pro  Asn Glu Gln Met Tyr  Trp Arg Val 
    1205                 1210                 1215             


Asp Glu  Ile Ser Asn Leu Lys  Lys Ile Glu Asn Lys  Tyr Lys Lys 
    1220                 1225                 1230             


Asp Ala  Ile Leu Thr Glu Glu  Asp Arg Lys Ile Met  Glu Ser Tyr 
    1235                 1240                 1245             


Ile Asp  Lys Ile Tyr Gln Gln  Phe Lys Ala Gly Lys  Tyr Lys Asn 
    1250                 1255                 1260             


Arg Arg  Thr Thr Asp Thr Ile  Ile Glu Lys Tyr Glu  Ile Ile Asp 
    1265                 1270                 1275             


Leu Asp  Thr Leu Asp Asn Lys  Gln Leu Tyr Gln Leu  Leu Val Ala 
    1280                 1285                 1290             


Phe Ile  Ser Leu Ser Tyr Lys  Thr Ser Asn Asn Ala  Val Asp Phe 
    1295                 1300                 1305             


Thr Val  Ile Gly Leu Gly Thr  Glu Cys Gly Lys Pro  Arg Ile Thr 
    1310                 1315                 1320             


Asn Leu  Pro Asp Asn Thr Tyr  Leu Val Tyr Lys Ser  Ile Thr Gly 
    1325                 1330                 1335             


Ile Tyr  Glu Lys Arg Ile Arg  Ile Lys 
    1340                 1345         


<210>  32
<211>  1354
<212>  PRT
<213>  Flavobacterium psychrophilum

<400>  32

Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ile Asn Glu Ala Glu Asn Glu Ile Glu Val Ser Ser Ile Val 
            20                  25                  30          


Asn Thr Gly Val Arg Ile Val Pro Leu Thr Thr Asp Glu Glu Ser Asp 
        35                  40                  45              


Phe Lys Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Gly Leu Gln Arg Phe Lys Gln Arg Arg Glu Ala 
65                  70                  75                  80  


Leu Leu Glu Thr Phe Asn Arg Ile Lys Phe Ile Ala Thr Asp Phe Val 
                85                  90                  95      


Tyr Ala Glu Thr Gly Ala Ala Thr Thr Phe Ser Ser Tyr Gln Leu Arg 
            100                 105                 110         


Ala Lys Ser Ala Val Glu Ala Val Thr Lys Glu Glu Leu Val Lys Val 
        115                 120                 125             


Leu Leu Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Thr Ala Glu Glu Gly Asp Ala Ile Asp Gly Met Lys Ile Ala Lys 
145                 150                 155                 160 


Glu Ile Phe Glu Asn Asn Leu Thr Pro Gly Gln Trp Val Tyr Asn Ser 
                165                 170                 175     


Leu Ser Lys Gly Gly Lys Phe Ile Pro Asp Phe Tyr His Ser Asp Leu 
            180                 185                 190         


Gln Lys Glu Leu Glu Lys Ile Val Arg Phe Gln Asn Gln Phe His Ser 
        195                 200                 205             


Glu Gln Ile Asn Asp Lys Leu Leu Ala Asp Ile Gln Gly Lys Ser Arg 
    210                 215                 220                 


Thr Gln Thr Ser Gln His Phe Ser Lys Thr Leu Asn Ile Pro Leu Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Thr Arg Glu Glu Thr Lys Leu Gln His Tyr Gln Trp 
                245                 250                 255     


Arg Asn Glu Ala Leu Ala Asn Glu Leu Asp Met Lys Ile Leu Ala Phe 
            260                 265                 270         


Ile Ile Thr Glu Ile Asn Asn Gln Ile Asn Gln Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Gln Glu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Gln Tyr Lys Gln Leu Gln Glu Asn Val His Ala Lys 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Glu Thr Gln Ala Lys Phe His Ser Glu Leu Asn Glu Lys 
            340                 345                 350         


Leu Lys Ala Glu Ile Arg Asp Ile Thr Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Val Ser Phe Cys Glu Phe Glu Lys Gly His 
    370                 375                 380                 


Lys Ala Ile Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Arg Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Asn Val Val Val Lys Asn Glu Thr Thr Lys Glu Val 
                405                 410                 415     


Phe Glu Leu Ser Glu Glu Leu Lys Gln Leu Ile Ala Glu Glu Leu Gln 
            420                 425                 430         


Phe Lys Glu Ser Met Thr Asp Val Gln Met Leu Thr Phe Cys Glu Leu 
        435                 440                 445             


Lys Lys Gly Thr His Thr Val Asn Phe Lys Lys Ile Glu Gly Asn Arg 
    450                 455                 460                 


Thr Asn Thr Ser Ile Tyr Lys Ala Phe Glu Lys Ile Leu Glu Val Glu 
465                 470                 475                 480 


Gly Tyr Glu Ile Asp Phe Ser Lys Met Lys Pro Leu Glu Ile Lys Glu 
                485                 490                 495     


Thr Val Ala Pro Ile Phe Glu Thr Leu Asn Ile Asn Thr Val Ile Leu 
            500                 505                 510         


Asp Phe Asp Pro Thr Ile Gln Gly Asn Asp Phe Asp Lys Gln Pro Tyr 
        515                 520                 525             


Tyr Gln Leu Trp His Leu Leu Tyr Ser Ala Glu Asp Asp Asp Lys Leu 
    530                 535                 540                 


Lys Glu Thr Leu Lys Thr Lys Phe Gly Phe Lys Glu Asn His Leu Pro 
545                 550                 555                 560 


Phe Ile Leu Asn Ile Asn Leu Gln Ala Asp Tyr Gly Ser Leu Ser Ala 
                565                 570                 575     


Lys Ala Ile Lys Lys Ile Leu Pro His Leu Met Asp Gly His Ile Tyr 
            580                 585                 590         


Asp Lys Ala Cys Leu Met Val Gly Tyr Asn His Ser Ser Ser Leu Thr 
        595                 600                 605             


Thr Ala Gln Asn Asn Asp Arg Val Leu Lys Asp Thr Leu Glu Leu Leu 
    610                 615                 620                 


Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gln 
625                 630                 635                 640 


Met Ile Asn Val Ile Asn Ala Ile Met Lys Asp Pro Ala Met Gly Lys 
                645                 650                 655     


Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys Ala Asn Asn 
            660                 665                 670         


Glu Gln Arg Lys Lys Ala Thr Ser Asp Ile Asn Thr Ala Thr Thr Glu 
        675                 680                 685             


His Glu Arg Ile Arg Lys Leu Leu His Ser Glu Phe Asn Ile Pro Arg 
    690                 695                 700                 


Val Thr Arg Asn Asp Ile Ile Arg Tyr Lys Leu Trp Leu Glu Thr Gly 
705                 710                 715                 720 


Gly Ile Ser Leu Tyr Thr Gly Asn Pro Ile Lys Ala Ser Asp Leu Phe 
                725                 730                 735     


Ser Lys Asn Tyr Asp Ile Glu His Ile Ile Pro Lys Ser Arg Leu Phe 
            740                 745                 750         


Asp Asp Ser Phe Ser Asn Lys Thr Leu Cys Glu Arg Gln Leu Asn Ile 
        755                 760                 765             


Asp Lys Ser Asn Lys Thr Ala Tyr Ser Phe Leu Gln Glu Lys Leu Ser 
    770                 775                 780                 


Glu Asn Asp Phe Ala Ala Tyr Glu Asn Arg Val Lys Asp Leu Phe Lys 
785                 790                 795                 800 


Thr Gly Lys Ile Lys Ser Tyr Thr Lys Tyr Lys Lys Leu Leu Met Ala 
                805                 810                 815     


Asp Asn Glu Ile Pro Glu Gly Phe Ile Asp Arg Gln Leu Arg Glu Thr 
            820                 825                 830         


Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Leu Glu Val Ser Arg 
        835                 840                 845             


Asn Val Thr Ala Thr Ile Gly Ser Val Thr Asp Lys Leu Arg Gln Asp 
    850                 855                 860                 


Trp Glu Leu Val Asp Val Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp 
865                 870                 875                 880 


Lys Leu Gly Leu Thr His Ile Glu Glu Gly Lys Asn Gly Glu Arg Leu 
                885                 890                 895     


Ser Lys Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala 
            900                 905                 910         


Met Asp Ala Ile Thr Val Ala Phe Thr Lys Pro Ala Tyr Ile Gln Tyr 
        915                 920                 925             


Leu Asn Asn Leu Asn Ala Lys Thr Gln Gly Glu Asn Lys Ala Asn Ser 
    930                 935                 940                 


Ile Ile Gly Ile Glu Asn Lys His Leu Tyr Arg Asp Lys Asn Asn Lys 
945                 950                 955                 960 


Leu Arg Phe Ile Ser Pro Met Lys Asn Phe Arg Glu Glu Ala Lys Lys 
                965                 970                 975     


Gln Leu Glu Ser Ile Leu Ile Ser Tyr Lys Ala Lys Asn Lys Val Val 
            980                 985                 990         


Thr Lys Asn Lys Asn Thr Thr Lys  Lys Ser Gly Gly Thr  Asn Gln Lys 
        995                 1000                 1005             


Ile Gln  Leu Thr Pro Arg Gly  Arg Leu His Lys Glu  Thr Val Tyr 
    1010                 1015                 1020             


Gly Lys  Leu Gln Gln Tyr Ala  Thr Lys Glu Glu Lys  Val Asn Ala 
    1025                 1030                 1035             


Ser Phe  Thr Glu Asp Tyr Ile  Gln Lys Val Ala Lys  Lys Glu Tyr 
    1040                 1045                 1050             


Arg Glu  Ala Leu Leu Lys Arg  Leu Glu Glu Asn Asp  Asn Asp Pro 
    1055                 1060                 1065             


Lys Lys  Ala Phe Thr Gly Lys  Asn Ala Leu Asn Lys  Thr Pro Ile 
    1070                 1075                 1080             


Tyr Ile  Ser Leu Lys Asp Asn  Ile Ile Val Pro Glu  Lys Val Lys 
    1085                 1090                 1095             


Thr Val  Trp Leu Glu Thr Asp  Tyr Thr Ile Arg Lys  Asp Ile Thr 
    1100                 1105                 1110             


Pro Asp  Leu Lys Ile Asp Lys  Val Ile Asp Val Gly  Ile Lys Arg 
    1115                 1120                 1125             


Ile Leu  Gln Asn Arg Leu Asn  Glu Phe Asn Gly Asp  Pro Lys Lys 
    1130                 1135                 1140             


Ala Phe  Val Asn Leu Gly Glu  Ser Pro Ile Trp Leu  Asn Lys Glu 
    1145                 1150                 1155             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Ser Asn 
    1160                 1165                 1170             


Ala Gln  Ala Leu His Thr Lys  Lys Asp His Leu Gly  Asn Glu Ile 
    1175                 1180                 1185             


Leu Asp  Lys Asn Gly Asn Pro  Ile Pro Val Asp Phe  Ile Ser Thr 
    1190                 1195                 1200             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Glu  Lys Gly Asn 
    1205                 1210                 1215             


Leu Gln  Glu Glu Val Val Ser  Phe Tyr Asp Ala Val  Ile Arg Arg 
    1220                 1225                 1230             


Asn Leu  Gly Leu Ser Val Ile  Asn Lys Asn His Glu  Lys Gly Trp 
    1235                 1240                 1245             


Glu Phe  Leu Phe Ser Met Lys  Gln Asn Glu Phe Phe  Ile Phe Pro 
    1250                 1255                 1260             


Ser Asp  Gly Phe Asn Pro His  Glu Ile Asp Leu Leu  Asn Pro Asn 
    1265                 1270                 1275             


Asn Tyr  His Leu Ile Ser Pro  Asn Ile Phe Arg Val  Gln Lys Ile 
    1280                 1285                 1290             


Ser Thr  Lys Asn Tyr Met Phe  Asn His His Leu Glu  Thr Lys Ala 
    1295                 1300                 1305             


Val Asp  Gly Glu Met Leu Lys  Ser Lys Lys Glu Leu  Ser Lys Thr 
    1310                 1315                 1320             


Ser Tyr  His Phe Ile Gln Thr  Pro Thr Asn Leu Asn  Gly Ile Ile 
    1325                 1330                 1335             


Lys Val  Arg Ile Asn His Leu  Gly Lys Ile Val His  Leu Gly Glu 
    1340                 1345                 1350             


Tyr 
    


<210>  33
<211>  1377
<212>  PRT
<213>  Streptococcus agalactiae

<400>  33

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Cys Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Asp Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Lys Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Val Asp Asn Gly Lys Lys Ile Cys Lys Val Lys Ile Val 
945                 950                 955                 960 


Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Phe 
                965                 970                 975     


Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Lys Ala  Ile Leu Thr Lys Tyr  Pro Gln Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Met Tyr Arg Gln Lys  Lys Leu Ser 
    1010                 1015                 1020             


Lys Ile  Val His Glu Asp Lys  Glu Glu Lys Tyr Ser  Glu Ala Thr 
    1025                 1030                 1035             


Arg Lys  Met Phe Phe Tyr Ser  Asn Leu Met Asn Met  Phe Lys Arg 
    1040                 1045                 1050             


Val Val  Arg Leu Ala Asp Gly  Ser Ile Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Thr  Gly Arg Tyr Met Arg  Lys Thr Ala Trp Asp  Lys Lys Lys 
    1070                 1075                 1080             


His Phe  Ala Thr Val Arg Lys  Val Leu Ser Tyr Pro  Gln Asn Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Ala His Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Ile Val Ala Tyr Ser  Val Leu Val Val Ala  Asp Ile Lys 
    1145                 1150                 1155             


Lys Gly  Lys Ala Gln Lys Leu  Lys Thr Val Thr Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Arg Phe Glu Lys Asn  Pro Ser Ala 
    1175                 1180                 1185             


Phe Leu  Glu Ser Lys Gly Tyr  Leu Asn Ile Arg Asp  Asp Lys Leu 
    1190                 1195                 1200             


Met Ile  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Thr Gln Phe  Met Lys Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


Arg Tyr  Asn Glu Ser Lys Gly  Lys Pro Glu Glu Ile  Glu Lys Lys 
    1250                 1255                 1260             


Gln Glu  Phe Val Asn Gln His  Val Ser Tyr Phe Asp  Asp Ile Leu 
    1265                 1270                 1275             


Gln Leu  Ile Asn Asp Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Glu Lys Ile Asn Lys  Leu Tyr Gln Asp Asn  Lys Glu Asn 
    1295                 1300                 1305             


Ile Pro  Val Asp Glu Leu Ala  Asn Asn Ile Ile Asn  Leu Phe Thr 
    1310                 1315                 1320             


Phe Thr  Ser Leu Gly Ala Pro  Ala Ala Phe Lys Phe  Phe Asp Lys 
    1325                 1330                 1335             


Ile Val  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asn 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Gly Lys Leu Gly  Glu Asp 
    1370                 1375         


<210>  34
<211>  1050
<212>  PRT
<213>  Gluconacetobacter diazotrophicus

<400>  34

Met Gly Glu Asn Met Ile Asp Glu Ser Leu Thr Phe Gly Ile Asp Leu 
1               5                   10                  15      


Gly Ile Gly Ser Cys Gly Trp Ala Val Leu Arg Arg Pro Ser Ala Phe 
            20                  25                  30          


Gly Arg Lys Gly Val Ile Glu Gly Met Gly Ser Trp Cys Phe Asp Val 
        35                  40                  45              


Pro Glu Thr Ser Lys Glu Arg Thr Pro Thr Asn Gln Ile Arg Arg Ser 
    50                  55                  60                  


Asn Arg Leu Leu Arg Arg Val Ile Arg Arg Arg Arg Asn Arg Met Ala 
65                  70                  75                  80  


Ala Ile Arg Arg Leu Leu His Ala Ala Gly Leu Leu Pro Ser Thr Asp 
                85                  90                  95      


Ser Asp Ala Leu Lys Arg Pro Gly His Asp Pro Trp Glu Leu Arg Ala 
            100                 105                 110         


Arg Gly Leu Asp Lys Pro Leu Lys Pro Val Glu Phe Ala Val Val Leu 
        115                 120                 125             


Gly His Ile Ala Lys Arg Arg Gly Phe Lys Ser Ala Ala Lys Arg Lys 
    130                 135                 140                 


Ala Thr Asn Ile Ser Ser Asp Asp Lys Lys Met Leu Thr Ala Leu Glu 
145                 150                 155                 160 


Ala Thr Arg Glu Arg Leu Gly Arg Tyr Arg Thr Val Gly Glu Met Phe 
                165                 170                 175     


Ala Arg Asp Pro Asp Phe Ala Ser Arg Arg Arg Asn Arg Glu Gly Lys 
            180                 185                 190         


Tyr Asp Arg Thr Thr Ala Arg Asp Asp Leu Glu His Glu Val His Ala 
        195                 200                 205             


Leu Phe Ala Ala Gln Arg Arg Leu Gly Gln Gly Phe Ala Ser Pro Glu 
    210                 215                 220                 


Leu Glu Glu Ala Phe Thr Ala Ser Ala Phe His Gln Arg Pro Met Gln 
225                 230                 235                 240 


Asp Ser Glu Arg Leu Val Gly Phe Cys Pro Phe Glu Arg Thr Glu Lys 
                245                 250                 255     


Arg Ala Ala Lys Leu Thr Pro Ser Phe Glu Arg Phe Arg Leu Leu Ala 
            260                 265                 270         


Arg Leu Leu Asn Leu Arg Ile Thr Thr Pro Asp Gly Glu Arg Pro Leu 
        275                 280                 285             


Thr Val Asp Glu Ile Ala Leu Val Thr Arg Asp Leu Gly Lys Thr Ala 
    290                 295                 300                 


Lys Leu Ser Ile Lys Arg Val Arg Thr Leu Ile Gly Leu Glu Asp Asn 
305                 310                 315                 320 


Gln Arg Phe Thr Thr Ile Arg Pro Glu Asp Glu Asp Arg Asp Ile Val 
                325                 330                 335     


Ala Arg Thr Gly Gly Ala Met Thr Gly Thr Ala Thr Leu Arg Lys Ala 
            340                 345                 350         


Leu Gly Glu Ala Leu Trp Thr Asp Met Gln Glu Arg Pro Glu Gln Leu 
        355                 360                 365             


Asp Ala Ile Val Gln Val Leu Ser Phe Phe Glu Ala Asn Glu Thr Ile 
    370                 375                 380                 


Thr Glu Lys Leu Arg Glu Ile Gly Leu Thr Leu Ala Val Leu Asp Val 
385                 390                 395                 400 


Leu Leu Thr Ala Leu Asp Ala Gly Val Phe Ala Lys Phe Lys Gly Ala 
                405                 410                 415     


Ala His Ile Ser Thr Lys Ala Ala Arg Asn Leu Leu Pro His Leu Glu 
            420                 425                 430         


Gln Gly Arg Arg Tyr Asp Glu Ala Cys Thr Met Ala Gly Tyr Asp His 
        435                 440                 445             


Ala Ala Ser Arg Leu Ser His His Gly Gln Ile Val Ala Lys Thr Gln 
    450                 455                 460                 


Phe Asn Ala Leu Val Thr Glu Ile Gly Glu Ser Ile Ala Asn Pro Ile 
465                 470                 475                 480 


Ala Arg Lys Ala Leu Ile Glu Gly Leu Lys Gln Ile Trp Ala Met Arg 
                485                 490                 495     


Asn His Trp Gly Leu Pro Gly Ser Ile His Val Glu Leu Ala Arg Asp 
            500                 505                 510         


Val Gly Asn Ser Ile Glu Lys Arg Arg Glu Ile Glu Lys His Ile Glu 
        515                 520                 525             


Lys Asn Thr Ala Leu Arg Ala Arg Glu Arg Arg Glu Val His Asp Leu 
    530                 535                 540                 


Leu Asp Leu Glu Asp Val Asn Gly Asp Thr Leu Leu Arg Tyr Arg Leu 
545                 550                 555                 560 


Trp Lys Glu Gln Gly Gly Lys Cys Leu Tyr Thr Gly Lys Ala Ile His 
                565                 570                 575     


Ile Arg Gln Ile Ala Ala Thr Asp Asn Ser Val Gln Val Asp His Ile 
            580                 585                 590         


Leu Pro Trp Ser Arg Phe Gly Asp Asp Ser Phe Asn Asn Lys Thr Leu 
        595                 600                 605             


Cys Leu Ala Ser Ala Asn Gln Gln Lys Lys Arg Ser Thr Pro Tyr Glu 
    610                 615                 620                 


Trp Leu Ser Gly Gln Thr Gly Asp Ala Trp Asn Ala Phe Val Gln Arg 
625                 630                 635                 640 


Ile Glu Thr Asn Lys Glu Leu Arg Gly Phe Lys Lys Arg Asn Tyr Leu 
                645                 650                 655     


Leu Lys Asn Ala Lys Glu Ala Glu Glu Lys Phe Arg Ser Arg Asn Leu 
            660                 665                 670         


Asn Asp Thr Arg Tyr Ala Ala Arg Leu Phe Ala Glu Ala Val Lys Leu 
        675                 680                 685             


Leu Tyr Ala Phe Gly Glu Arg Gln Glu Lys Gly Gly Asn Arg Arg Val 
    690                 695                 700                 


Phe Thr Arg Pro Gly Ala Leu Thr Ala Ala Leu Arg Gln Ala Trp Gly 
705                 710                 715                 720 


Val Glu Ser Leu Lys Lys Gln Asp Gly Lys Arg Ile Asn Asp Asp Arg 
                725                 730                 735     


His His Ala Leu Asp Ala Leu Thr Val Ala Ala Val Asp Glu Ala Glu 
            740                 745                 750         


Ile Gln Arg Leu Thr Lys Ser Phe His Glu Trp Glu Gln Gln Gly Leu 
        755                 760                 765             


Gly Arg Pro Leu Arg Arg Val Glu Pro Pro Trp Glu Ser Phe Arg Ala 
    770                 775                 780                 


Asp Val Glu Ala Thr Tyr Pro Glu Val Phe Val Ala Arg Pro Glu Arg 
785                 790                 795                 800 


Arg Arg Ala Arg Gly Glu Gly His Ala Ala Thr Ile Arg Gln Val Lys 
                805                 810                 815     


Glu Arg Glu Cys Thr Pro Ile Val Phe Glu Arg Lys Ala Val Ser Ser 
            820                 825                 830         


Leu Lys Glu Ala Asp Leu Glu Arg Ile Lys Asp Gly Glu Arg Asn Glu 
        835                 840                 845             


Ala Ile Val Glu Ala Ile Arg Ser Trp Ile Ala Thr Gly Arg Pro Ala 
    850                 855                 860                 


Asp Ala Pro Pro Arg Ser Pro Arg Gly Asp Ile Ile Thr Lys Ile Arg 
865                 870                 875                 880 


Leu Ala Thr Thr Ile Lys Ala Ala Val Pro Val Arg Gly Gly Thr Ala 
                885                 890                 895     


Gly Arg Gly Glu Met Val Arg Ala Asp Val Phe Ser Lys Pro Asn Arg 
            900                 905                 910         


Arg Gly Lys Asp Glu Trp Tyr Leu Val Pro Val Tyr Pro His Gln Ile 
        915                 920                 925             


Met Asn Arg Lys Ala Trp Pro Lys Pro Pro Met Arg Ser Ile Val Ala 
    930                 935                 940                 


Asn Lys Asp Glu Asp Glu Trp Thr Glu Val Gly Pro Glu His Gln Phe 
945                 950                 955                 960 


Arg Phe Ser Leu Tyr Pro Arg Ser Asn Ile Glu Ile Ile Arg Pro Ser 
                965                 970                 975     


Gly Glu Val Ile Glu Gly Tyr Phe Val Gly Leu His Arg Asn Thr Gly 
            980                 985                 990         


Ala Leu Thr Ile Ser Ala His Asn  Asp Pro Lys Ser Ile  His Ser Gly 
        995                 1000                 1005             


Ile Gly  Thr Lys Thr Leu Leu  Ala Ile Ser Lys Tyr  Gln Val Asp 
    1010                 1015                 1020             


Arg Phe  Gly Arg Lys Ser Pro  Val Arg Lys Glu Val  Arg Thr Trp 
    1025                 1030                 1035             


His Gly  Glu Ala Cys Ile Ser  Pro Thr Pro Pro Gly  
    1040                 1045                 1050 


<210>  35
<211>  131
<212>  PRT
<213>  Helicobacter hepaticus

<400>  35

Met Arg Ile Leu Gly Phe Asp Ile Gly Ile Thr Ser Ile Gly Trp Ala 
1               5                   10                  15      


Tyr Val Glu Ser Asn Glu Leu Lys Asp Cys Gly Val Arg Ile Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Asn Gly Asp Ser Leu Ala Ala Pro Arg Arg 
        35                  40                  45              


Glu Ala Arg Gly Ala Arg Arg Arg Leu Ala Arg Arg Lys Ala Arg Leu 
    50                  55                  60                  


Asn Ala Ile Lys Arg Leu Leu Cys Lys Glu Phe Glu Leu Asn Leu Asn 
65                  70                  75                  80  


Asp Tyr Leu Ala Asn Asp Gly Glu Leu Pro Lys Ala Tyr Gln Thr Ser 
                85                  90                  95      


Lys Asp Thr Lys Ser Pro Tyr Glu Leu Tyr Thr Ala Phe His Trp Ile 
            100                 105                 110         


Ile Phe Ala Phe Cys Ser Ile Ala Ser Ser Leu Ser Asn Arg Gln Met 
        115                 120                 125             


Leu Pro Ile 
    130     


<210>  36
<211>  1361
<212>  PRT
<213>  Lactobacillus casei BL23

<400>  36

Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Gly Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Val Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 
545                 550                 555                 560 


Ser Ile Glu Gln Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Ser Val Thr Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly 
            580                 585                 590         


Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro 
    610                 615                 620                 


Asp Ala Ile Asp Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Lys Glu Ile Asn Trp Leu Asp Ser Gln Thr Ile Thr Lys Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Phe Leu Asn Gly 
        675                 680                 685             


Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gln Glu Leu Phe Leu Ser 
    690                 695                 700                 


Asn Asn Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys 
705                 710                 715                 720 


Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 
    770                 775                 780                 


Gly Lys Arg Thr Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala His Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Thr Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys 
                885                 890                 895     


Met Asn Ala Thr Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr 
        915                 920                 925             


Ala Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Val Ala Ala Gln Tyr Pro Glu Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Glu 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Phe Pro Asn 
        995                 1000                 1005             


Leu Gln  Ala Phe Phe Thr Tyr  Gly Lys Phe Lys Lys  Ala Asp Val 
    1010                 1015                 1020             


Lys Lys  Leu Arg Gly Phe Asn  Phe Ile Arg Asp Ile  Thr His Ala 
    1025                 1030                 1035             


Glu Asp  Lys Ile Val Val Lys  Asp Thr Gly Glu Val  Ile Trp Asp 
    1040                 1045                 1050             


Lys Lys  Arg Asp Val Asp Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val His Phe Glu Lys  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Val Tyr Gly  Ala Lys Asp Ser Lys  Glu Ala Gly 
    1085                 1090                 1095             


Gly Lys  Lys Gln Leu Ile Ser  Lys Lys Lys Gly Tyr  Pro Val Asp 
    1100                 1105                 1110             


Ile Tyr  Gly Gly Tyr Thr Gln  Glu Thr Gly Ser Tyr  Leu Ser Val 
    1115                 1120                 1125             


Val Arg  Leu Thr Lys Lys Ala  Met Tyr Ala Val Val  Lys Val Ser 
    1130                 1135                 1140             


Thr Arg  Asp Ala Ala Lys Leu  Ala Val Ala Lys Ser  Ile Ser Glu 
    1145                 1150                 1155             


Gln Lys  Glu Asn Glu Thr Leu  Asn Asp Ile Ile Asp  Glu Lys Leu 
    1160                 1165                 1170             


Ser Lys  Ile Ser Lys Asn Gly  Lys Ile Thr His Glu  Leu Phe Glu 
    1175                 1180                 1185             


Val Val  Leu Pro Arg Val Gly  Gln Lys Thr Leu Phe  Lys Asn Ser 
    1190                 1195                 1200             


Lys Tyr  Asn Leu Phe Leu Val  Asn Ser Asp Thr Tyr  Met His Asn 
    1205                 1210                 1215             


Tyr Gln  Glu Leu Trp Met Pro  Arg Glu Tyr Gln Lys  Met Trp Lys 
    1220                 1225                 1230             


Asp Ile  Ser Leu Ser Lys Tyr  Gly Asp Ala Gln Thr  Glu Asp Gln 
    1235                 1240                 1245             


Leu Asp  Gln Ile Phe Gly Phe  Ile Val Ser Gln Val  Asn Ser Tyr 
    1250                 1255                 1260             


Phe Asn  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asn Asp 
    1265                 1270                 1275             


Ala Ala  Asp Lys Phe Ala Thr  Leu Pro Met Arg Asp  Thr Asp Asp 
    1280                 1285                 1290             


Met Gln  Gly Lys Ile Ala Thr  Ile Gly Gln Leu Leu  Ile Gly Leu 
    1295                 1300                 1305             


Gln Ala  Asn Ala Ala Arg Ser  Asp Leu Arg Asn Leu  Asp Ile Lys 
    1310                 1315                 1320             


Thr Pro  Leu Gly Leu Leu Gln  Ile Pro Asn Gly Ile  Ser Leu Asp 
    1325                 1330                 1335             


Ser Asp  Thr Ser Val Val Tyr  Gln Ser Pro Thr Gly  Leu Leu Glu 
    1340                 1345                 1350             


Arg Glu  Val His Leu Ser Asp  Leu 
    1355                 1360     


<210>  37
<211>  1334
<212>  PRT
<213>  Listeria innocua

<400>  37

Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Glu Tyr 
        115                 120                 125             


His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu Lys Lys Leu 
        195                 200                 205             


Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys Val Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu Ala Leu Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Ala Tyr Ser 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr His Glu Glu 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys His 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Met 
    370                 375                 380                 


Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys Thr Ser Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu Asn Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Met 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Thr Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Asp Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Asp Thr Val Lys  Lys Val Met 
    1055                 1060                 1065             


Ser Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Thr  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Val  Ile Glu Tyr 
    1115                 1120                 1125             


Ala Lys  Gly Lys Asn Lys Leu  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Val Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Ala Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Glu Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Val Thr  Leu Leu His His Ala  Ala Asn Cys 
    1205                 1210                 1215             


Glu Val  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Ala Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Glu Ala  Asn Leu Asn Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Thr Thr  Ile Glu Arg Lys Arg  Tyr Asn Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210>  38
<211>  1149
<212>  PRT
<213>  Lactobacillus salivarius

<400>  38

Met Glu Arg Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly 
1               5                   10                  15      


Trp Ala Val Ile Gly Asp Asp Phe Lys Ile Lys Arg Lys Lys Gly Lys 
            20                  25                  30          


Asn Leu Ile Gly Val Arg Leu Phe Lys Glu Gly Asp Thr Ala Ala Glu 
        35                  40                  45              


Arg Arg Gly Phe Arg Thr Gln Arg Arg Arg Leu Asn Arg Arg Lys Trp 
    50                  55                  60                  


Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Met Ala Glu Val 
65                  70                  75                  80  


Asp Lys Tyr Phe Phe Ala Arg Leu Lys Glu Ser Asn Leu Ser Pro Lys 
                85                  90                  95      


Asp Ser Asn Lys Lys Tyr Leu Gly Ser Leu Leu Phe Pro Asp Ile Ser 
            100                 105                 110         


Asp Ser Asn Phe Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Arg 
        115                 120                 125             


Asp Leu Met Glu Lys Asp Lys Lys Phe Asp Leu Arg Glu Ile Tyr Leu 
    130                 135                 140                 


Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Glu Lys Val 
145                 150                 155                 160 


Pro Ala Lys Asn Tyr Lys Asn Ser Gly Ala Ser Ile Gly Phe Leu Leu 
                165                 170                 175     


Glu Glu Val Asn Asp Leu Tyr Gly Asn Ile Ile Gly Asn Glu Asp Val 
            180                 185                 190         


Ala Ile Leu Asp Asn Asp Lys Phe Glu Asp Val Glu Lys Ile Ile Leu 
        195                 200                 205             


Asn Asp Glu Ile Arg Asn Ile Asp Lys Gln Lys Asn Val Gly Arg Leu 
    210                 215                 220                 


Leu Val Lys Asp Lys Lys Glu Lys Asn Ile Val Thr Ala Phe Ser Lys 
225                 230                 235                 240 


Ala Ile Phe Gly Tyr Lys Phe Asn Leu Glu Asp Leu Leu Leu Ile Glu 
                245                 250                 255     


Ser Asp Glu Lys Asn Lys Leu Thr Phe Asn Asp Glu Asn Ile Asp Asp 
            260                 265                 270         


Ile Phe Asn Glu Leu Ser His Ser Leu Asn Asp Asn Gln Met Asp Leu 
        275                 280                 285             


Leu Thr Lys Thr Arg Glu Ile Tyr Phe Lys Phe Lys Leu Asn Met Ile 
    290                 295                 300                 


Val Pro Thr Gly Tyr Thr Ile Ser Glu Ser Met Ile Glu Lys Tyr Glu 
305                 310                 315                 320 


Met His Lys Ala His Leu Lys Met Tyr Lys Glu Phe Ile Asn Thr Leu 
                325                 330                 335     


Asn Ala Lys Asp Arg Lys Ile Leu Lys Asn Ala Tyr Ser Asp Tyr Ile 
            340                 345                 350         


Asn Asn Glu Lys Ala Lys Ala Ala Asn Ala Gln Glu Asn Phe Tyr Lys 
        355                 360                 365             


Thr Val Lys Lys Thr Ile Lys Glu Asn Asp Ser Asp Thr Ala Lys Lys 
    370                 375                 380                 


Ile Ile Gly Leu Ile Asp Glu Gly Asn Phe Met Pro Lys Gln Arg Thr 
385                 390                 395                 400 


Gly Glu Asn Gly Val Ile Pro His Gln Leu His Gln Ile Glu Leu Asp 
                405                 410                 415     


Arg Ile Ile Glu Asn Gln Ala Lys Tyr Tyr Pro Trp Leu Ala Glu Glu 
            420                 425                 430         


Asn Pro Val Glu Lys Asn Arg Lys Phe Ala Lys Tyr Lys Leu Asp Glu 
        435                 440                 445             


Leu Val Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Asp Lys 
    450                 455                 460                 


Thr Glu Ser Asn Lys Asn Glu Lys Glu Thr Lys Phe Ala Trp Met Val 
465                 470                 475                 480 


Arg Lys Ala Lys Gly Thr Ile Thr Pro Trp Asn Phe Glu Asn Leu Val 
                485                 490                 495     


Asp Arg Thr Glu Ser Ala Asn Arg Phe Ile Lys Arg Met Thr Ser Lys 
            500                 505                 510         


Asp Thr Tyr Ile Ile Gly Glu Asp Val Leu Pro Ala Ser Ser Leu Leu 
        515                 520                 525             


Tyr Glu Lys Tyr Lys Val Leu Asn Glu Leu Asn Asn Ile Lys Val Asn 
    530                 535                 540                 


Lys Lys Lys Leu Asp Val Glu Gln Lys Gln His Val Tyr Leu Asp Leu 
545                 550                 555                 560 


Phe Thr Thr Arg Lys Asn Val Thr Lys Asp Asp Leu Ala Thr Ser Leu 
                565                 570                 575     


Asn Cys Asp Val Glu Ser Ile Thr Gly Leu Thr Asp Asn Lys Lys Phe 
            580                 585                 590         


Asn Ser Ser Leu Ser Ser Tyr Ile Asp Leu Lys Ala Ile Leu Gly Asn 
        595                 600                 605             


Ile Val Asp Asp Tyr Ser Lys Asn Glu Asp Leu Glu Lys Ile Ile Glu 
    610                 615                 620                 


Tyr Ser Thr Ile Phe Glu Asp Gly Asn Ile Tyr Lys Glu Lys Leu Ser 
625                 630                 635                 640 


Glu Ile Ser Trp Leu Thr Asp Glu Gln Ile Glu Lys Leu Ser Asn Ile 
                645                 650                 655     


His Phe Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gln Ile 
            660                 665                 670         


Thr Asn Glu Asn Gly Glu Arg Ile Ile Asp Thr Leu Trp Asn Thr Ser 
        675                 680                 685             


Asn Asn Phe Ile Gln Val Ile Ser Asp Glu Ser Ile Gln Ala Lys Leu 
    690                 695                 700                 


Ala Glu Ile Asn Gly Glu Tyr Ala Asn Lys Tyr Asn Leu Glu Asp Ile 
705                 710                 715                 720 


Leu Asp Glu Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg Gln 
                725                 730                 735     


Val Met Lys Val Val Glu Asp Ile Glu Lys Ala Met Lys Cys Glu Pro 
            740                 745                 750         


Thr Ser Ile Ala Ile Glu Phe Thr Arg Glu Lys Arg Lys Ser Lys Leu 
        755                 760                 765             


Thr Asn Thr Arg Tyr Lys Lys Ile Ser Glu Thr Tyr Glu Lys Ile Thr 
    770                 775                 780                 


Asp Glu Leu Ile Ser Glu Tyr Glu Leu Gly Lys Leu Gln Ser Glu Leu 
785                 790                 795                 800 


Asp Ser Lys Val Asn Asn Met Arg Asp Arg Tyr Tyr Leu Tyr Phe Met 
                805                 810                 815     


Gln Leu Gly Arg Asp Met Tyr Thr Gly Glu Lys Met Asn Ile Asp Glu 
            820                 825                 830         


Leu His Gln Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Ile 
        835                 840                 845             


Lys Asp Asp Ser Leu Asn Asn Arg Val Leu Thr Ser Lys Ser Val Asn 
    850                 855                 860                 


Ile Lys Glu Lys Ser Asp Lys Thr Ala Ala Asp Leu Tyr Ala Ala Lys 
865                 870                 875                 880 


Met Gly Asp Phe Trp Arg Lys Leu Arg Lys Gln Gly Leu Met Thr Glu 
                885                 890                 895     


Gln Lys Tyr Lys Asn Leu Leu Thr Arg Thr Asp Ser Ile Asn Lys Tyr 
            900                 905                 910         


Thr Lys Gln Ser Phe Ile Lys Arg Gln Leu Val Glu Thr Ser Gln Val 
        915                 920                 925             


Val Lys Leu Ala Ala Asn Ile Leu Gln Asp Lys Tyr Arg Asn Thr Lys 
    930                 935                 940                 


Ile Ile Glu Ile Arg Ala Arg Leu Asn Ser Asp Leu Arg Lys Lys Tyr 
945                 950                 955                 960 


Glu Leu Ile Lys Asn Arg Glu Val Asn Asp Tyr His His Ala Ile Asp 
                965                 970                 975     


Gly Tyr Leu Thr Thr Phe Val Gly Gln Tyr Leu Tyr Lys Val Tyr Pro 
            980                 985                 990         


Lys Leu Arg Ser Tyr Phe Val Tyr  Asp Asp Phe Lys Lys  Leu Asp Ser 
        995                 1000                 1005             


Asn Tyr  Leu Lys His Met Asp  Lys Phe Asn Phe Ile  Trp Lys Leu 
    1010                 1015                 1020             


Glu Asp  Lys Lys Ala Glu Asp  Val Tyr Asp Lys Val  Asn Asp Glu 
    1025                 1030                 1035             


Phe Val  Leu Asn Val Pro Glu  Met Lys Glu Tyr Ile  Arg Lys Ile 
    1040                 1045                 1050             


Tyr Asn  Tyr Lys Tyr Met Leu  Val Ser Lys Glu Val  Thr Thr Lys 
    1055                 1060                 1065             


Asn Gly  Ala Phe Tyr Asp Gln  Thr Lys Tyr Asn Ala  Lys Thr Ile 
    1070                 1075                 1080             


Asn Leu  Ile Pro Ile Lys Lys  Asp Lys Pro Thr Asn  Ile Tyr Gly 
    1085                 1090                 1095             


Gly Tyr  Lys Gly Lys Val Ser  Ser Tyr Met Met Leu  Val Lys Ile 
    1100                 1105                 1110             


Gln Lys  Lys Lys Glu Val Ile  Tyr Lys Phe Val Gly  Val Pro Arg 
    1115                 1120                 1125             


Leu Trp  Thr Asp Glu Leu Asp  Arg Leu Ile Asp Thr  Asp Glu Lys 
    1130                 1135                 1140             


Lys Ala  Leu Leu Lys Lys 
    1145                 


<210>  39
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes MGAS6180

<400>  39

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asn Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Val Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  40
<211>  1368
<212>  PRT
<213>  Streptococcus

<400>  40

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Leu Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  41
<211>  1371
<212>  PRT
<213>  Streptococcus

<400>  41

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Ser  Asp 
    1370     


<210>  42
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes MGAS2096

<400>  42

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  43
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes MGAS9429

<400>  43

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Val Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  44
<211>  1236
<212>  PRT
<213>  Mycoplasma mobile

<400>  44

Met Tyr Phe Tyr Lys Asn Lys Glu Asn Lys Leu Asn Lys Lys Val Val 
1               5                   10                  15      


Leu Gly Leu Asp Leu Gly Ile Ala Ser Val Gly Trp Cys Leu Thr Asp 
            20                  25                  30          


Ile Ser Gln Lys Glu Asp Asn Lys Phe Pro Ile Ile Leu His Gly Val 
        35                  40                  45              


Arg Leu Phe Glu Thr Val Asp Asp Ser Asp Asp Lys Leu Leu Asn Glu 
    50                  55                  60                  


Thr Arg Arg Lys Lys Arg Gly Gln Arg Arg Arg Asn Arg Arg Leu Phe 
65                  70                  75                  80  


Thr Arg Lys Arg Asp Phe Ile Lys Tyr Leu Ile Asp Asn Asn Ile Ile 
                85                  90                  95      


Glu Leu Glu Phe Asp Lys Asn Pro Lys Ile Leu Val Arg Asn Phe Ile 
            100                 105                 110         


Glu Lys Tyr Ile Asn Pro Phe Ser Lys Asn Leu Glu Leu Lys Tyr Lys 
        115                 120                 125             


Ser Val Thr Asn Leu Pro Ile Gly Phe His Asn Leu Arg Lys Ala Ala 
    130                 135                 140                 


Ile Asn Glu Lys Tyr Lys Leu Asp Lys Ser Glu Leu Ile Val Leu Leu 
145                 150                 155                 160 


Tyr Phe Tyr Leu Ser Leu Arg Gly Ala Phe Phe Asp Asn Pro Glu Asp 
                165                 170                 175     


Thr Lys Ser Lys Glu Met Asn Lys Asn Glu Ile Glu Ile Phe Asp Lys 
            180                 185                 190         


Asn Glu Ser Ile Lys Asn Ala Glu Phe Pro Ile Asp Lys Ile Ile Glu 
        195                 200                 205             


Phe Tyr Lys Ile Ser Gly Lys Ile Arg Ser Thr Ile Asn Leu Lys Phe 
    210                 215                 220                 


Gly His Gln Asp Tyr Leu Lys Glu Ile Lys Gln Val Phe Glu Lys Gln 
225                 230                 235                 240 


Asn Ile Asp Phe Met Asn Tyr Glu Lys Phe Ala Met Glu Glu Lys Ser 
                245                 250                 255     


Phe Phe Ser Arg Ile Arg Asn Tyr Ser Glu Gly Pro Gly Asn Glu Lys 
            260                 265                 270         


Ser Phe Ser Lys Tyr Gly Leu Tyr Ala Asn Glu Asn Gly Asn Pro Glu 
        275                 280                 285             


Leu Ile Ile Asn Glu Lys Gly Gln Lys Ile Tyr Thr Lys Ile Phe Lys 
    290                 295                 300                 


Thr Leu Trp Glu Ser Lys Ile Gly Lys Cys Ser Tyr Asp Lys Lys Leu 
305                 310                 315                 320 


Tyr Arg Ala Pro Lys Asn Ser Phe Ser Ala Lys Val Phe Asp Ile Thr 
                325                 330                 335     


Asn Lys Leu Thr Asp Trp Lys His Lys Asn Glu Tyr Ile Ser Glu Arg 
            340                 345                 350         


Leu Lys Arg Lys Ile Leu Leu Ser Arg Phe Leu Asn Lys Asp Ser Lys 
        355                 360                 365             


Ser Ala Val Glu Lys Ile Leu Lys Glu Glu Asn Ile Lys Phe Glu Asn 
    370                 375                 380                 


Leu Ser Glu Ile Ala Tyr Asn Lys Asp Asp Asn Lys Ile Asn Leu Pro 
385                 390                 395                 400 


Ile Ile Asn Ala Tyr His Ser Leu Thr Thr Ile Phe Lys Lys His Leu 
                405                 410                 415     


Ile Asn Phe Glu Asn Tyr Leu Ile Ser Asn Glu Asn Asp Leu Ser Lys 
            420                 425                 430         


Leu Met Ser Phe Tyr Lys Gln Gln Ser Glu Lys Leu Phe Val Pro Asn 
        435                 440                 445             


Glu Lys Gly Ser Tyr Glu Ile Asn Gln Asn Asn Asn Val Leu His Ile 
    450                 455                 460                 


Phe Asp Ala Ile Ser Asn Ile Leu Asn Lys Phe Ser Thr Ile Gln Asp 
465                 470                 475                 480 


Arg Ile Arg Ile Leu Glu Gly Tyr Phe Glu Phe Ser Asn Leu Lys Lys 
                485                 490                 495     


Asp Val Lys Ser Ser Glu Ile Tyr Ser Glu Ile Ala Lys Leu Arg Glu 
            500                 505                 510         


Phe Ser Gly Thr Ser Ser Leu Ser Phe Gly Ala Tyr Tyr Lys Phe Ile 
        515                 520                 525             


Pro Asn Leu Ile Ser Glu Gly Ser Lys Asn Tyr Ser Thr Ile Ser Tyr 
    530                 535                 540                 


Glu Glu Lys Ala Leu Gln Asn Gln Lys Asn Asn Phe Ser His Ser Asn 
545                 550                 555                 560 


Leu Phe Glu Lys Thr Trp Val Glu Asp Leu Ile Ala Ser Pro Thr Val 
                565                 570                 575     


Lys Arg Ser Leu Arg Gln Thr Met Asn Leu Leu Lys Glu Ile Phe Lys 
            580                 585                 590         


Tyr Ser Glu Lys Asn Asn Leu Glu Ile Glu Lys Ile Val Val Glu Val 
        595                 600                 605             


Thr Arg Ser Ser Asn Asn Lys His Glu Arg Lys Lys Ile Glu Gly Ile 
    610                 615                 620                 


Asn Lys Tyr Arg Lys Glu Lys Tyr Glu Glu Leu Lys Lys Val Tyr Asp 
625                 630                 635                 640 


Leu Pro Asn Glu Asn Thr Thr Leu Leu Lys Lys Leu Trp Leu Leu Arg 
                645                 650                 655     


Gln Gln Gln Gly Tyr Asp Ala Tyr Ser Leu Arg Lys Ile Glu Ala Asn 
            660                 665                 670         


Asp Val Ile Asn Lys Pro Trp Asn Tyr Asp Ile Asp His Ile Val Pro 
        675                 680                 685             


Arg Ser Ile Ser Phe Asp Asp Ser Phe Ser Asn Leu Val Ile Val Asn 
    690                 695                 700                 


Lys Leu Asp Asn Ala Lys Lys Ser Asn Asp Leu Ser Ala Lys Gln Phe 
705                 710                 715                 720 


Ile Glu Lys Ile Tyr Gly Ile Glu Lys Leu Lys Glu Ala Lys Glu Asn 
                725                 730                 735     


Trp Gly Asn Trp Tyr Leu Arg Asn Ala Asn Gly Lys Ala Phe Asn Asp 
            740                 745                 750         


Lys Gly Lys Phe Ile Lys Leu Tyr Thr Ile Asp Asn Leu Asp Glu Phe 
        755                 760                 765             


Asp Asn Ser Asp Phe Ile Asn Arg Asn Leu Ser Asp Thr Ser Tyr Ile 
    770                 775                 780                 


Thr Asn Ala Leu Val Asn His Leu Thr Phe Ser Asn Ser Lys Tyr Lys 
785                 790                 795                 800 


Tyr Ser Val Val Ser Val Asn Gly Lys Gln Thr Ser Asn Leu Arg Asn 
                805                 810                 815     


Gln Ile Ala Phe Val Gly Ile Lys Asn Asn Lys Glu Thr Glu Arg Glu 
            820                 825                 830         


Trp Lys Arg Pro Glu Gly Phe Lys Ser Ile Asn Ser Asn Asp Phe Leu 
        835                 840                 845             


Ile Arg Glu Glu Gly Lys Asn Asp Val Lys Asp Asp Val Leu Ile Lys 
    850                 855                 860                 


Asp Arg Ser Phe Asn Gly His His Ala Glu Asp Ala Tyr Phe Ile Thr 
865                 870                 875                 880 


Ile Ile Ser Gln Tyr Phe Arg Ser Phe Lys Arg Ile Glu Arg Leu Asn 
                885                 890                 895     


Val Asn Tyr Arg Lys Glu Thr Arg Glu Leu Asp Asp Leu Glu Lys Asn 
            900                 905                 910         


Asn Ile Lys Phe Lys Glu Lys Ala Ser Phe Asp Asn Phe Leu Leu Ile 
        915                 920                 925             


Asn Ala Leu Asp Glu Leu Asn Glu Lys Leu Asn Gln Met Arg Phe Ser 
    930                 935                 940                 


Arg Met Val Ile Thr Lys Lys Asn Thr Gln Leu Phe Asn Glu Thr Leu 
945                 950                 955                 960 


Tyr Ser Gly Lys Tyr Asp Lys Gly Lys Asn Thr Ile Lys Lys Val Glu 
                965                 970                 975     


Lys Leu Asn Leu Leu Asp Asn Arg Thr Asp Lys Ile Lys Lys Ile Glu 
            980                 985                 990         


Glu Phe Phe Asp Glu Asp Lys Leu  Lys Glu Asn Glu Leu  Thr Lys Leu 
        995                 1000                 1005             


His Ile  Phe Asn His Asp Lys  Asn Leu Tyr Glu Thr  Leu Lys Ile 
    1010                 1015                 1020             


Ile Trp  Asn Glu Val Lys Ile  Glu Ile Lys Asn Lys  Asn Leu Asn 
    1025                 1030                 1035             


Glu Lys  Asn Tyr Phe Lys Tyr  Phe Val Asn Lys Lys  Leu Gln Glu 
    1040                 1045                 1050             


Gly Lys  Ile Ser Phe Asn Glu  Trp Val Pro Ile Leu  Asp Asn Asp 
    1055                 1060                 1065             


Phe Lys  Ile Ile Arg Lys Ile  Arg Tyr Ile Lys Phe  Ser Ser Glu 
    1070                 1075                 1080             


Glu Lys  Glu Thr Asp Glu Ile  Ile Phe Ser Gln Ser  Asn Phe Leu 
    1085                 1090                 1095             


Lys Ile  Asp Gln Arg Gln Asn  Phe Ser Phe His Asn  Thr Leu Tyr 
    1100                 1105                 1110             


Trp Val  Gln Ile Trp Val Tyr  Lys Asn Gln Lys Asp  Gln Tyr Cys 
    1115                 1120                 1125             


Phe Ile  Ser Ile Asp Ala Arg  Asn Ser Lys Phe Glu  Lys Asp Glu 
    1130                 1135                 1140             


Ile Lys  Ile Asn Tyr Glu Lys  Leu Lys Thr Gln Lys  Glu Lys Leu 
    1145                 1150                 1155             


Gln Ile  Ile Asn Glu Glu Pro  Ile Leu Lys Ile Asn  Lys Gly Asp 
    1160                 1165                 1170             


Leu Phe  Glu Asn Glu Glu Lys  Glu Leu Phe Tyr Ile  Val Gly Arg 
    1175                 1180                 1185             


Asp Glu  Lys Pro Gln Lys Leu  Glu Ile Lys Tyr Ile  Leu Gly Lys 
    1190                 1195                 1200             


Lys Ile  Lys Asp Gln Lys Gln  Ile Gln Lys Pro Val  Lys Lys Tyr 
    1205                 1210                 1215             


Phe Pro  Asn Trp Lys Lys Val  Asn Leu Thr Tyr Met  Gly Glu Ile 
    1220                 1225                 1230             


Phe Lys  Lys 
    1235     


<210>  45
<211>  1314
<212>  PRT
<213>  Mycoplasma synoviae

<400>  45

Met Leu Arg Leu Tyr Cys Ala Asn Asn Leu Val Leu Asn Asn Val Gln 
1               5                   10                  15      


Asn Leu Trp Lys Tyr Leu Leu Leu Leu Ile Phe Asp Lys Lys Ile Ile 
            20                  25                  30          


Phe Leu Phe Lys Ile Lys Val Ile Leu Ile Arg Arg Tyr Met Glu Asn 
        35                  40                  45              


Asn Asn Lys Glu Lys Ile Val Ile Gly Phe Asp Leu Gly Val Ala Ser 
    50                  55                  60                  


Val Gly Trp Ser Ile Val Asn Ala Glu Thr Lys Glu Val Ile Asp Leu 
65                  70                  75                  80  


Gly Val Arg Leu Phe Ser Glu Pro Glu Lys Ala Asp Tyr Arg Arg Ala 
                85                  90                  95      


Lys Arg Thr Thr Arg Arg Leu Leu Arg Arg Lys Lys Phe Lys Arg Glu 
            100                 105                 110         


Lys Phe His Lys Leu Ile Leu Lys Asn Ala Glu Ile Phe Gly Leu Gln 
        115                 120                 125             


Ser Arg Asn Glu Ile Leu Asn Val Tyr Lys Asp Gln Ser Ser Lys Tyr 
    130                 135                 140                 


Arg Asn Ile Leu Lys Leu Lys Ile Asn Ala Leu Lys Glu Glu Ile Lys 
145                 150                 155                 160 


Pro Ser Glu Leu Val Trp Ile Leu Arg Asp Tyr Leu Gln Asn Arg Gly 
                165                 170                 175     


Tyr Phe Tyr Lys Asn Glu Lys Leu Thr Asp Glu Phe Val Ser Asn Ser 
            180                 185                 190         


Phe Pro Ser Lys Lys Leu His Glu His Tyr Glu Lys Tyr Gly Phe Phe 
        195                 200                 205             


Arg Gly Ser Val Lys Leu Asp Asn Lys Leu Asp Asn Lys Lys Asp Lys 
    210                 215                 220                 


Ala Lys Glu Lys Asp Glu Glu Glu Glu Ser Asp Ala Lys Lys Glu Ser 
225                 230                 235                 240 


Glu Glu Leu Ile Phe Ser Asn Lys Gln Trp Ile Asn Glu Ile Val Lys 
                245                 250                 255     


Val Phe Glu Asn Gln Ser Tyr Leu Thr Glu Ser Phe Lys Glu Glu Tyr 
            260                 265                 270         


Leu Lys Leu Phe Asn Tyr Val Arg Pro Phe Asn Lys Gly Pro Gly Ser 
        275                 280                 285             


Lys Asn Ser Arg Thr Ala Tyr Gly Val Phe Ser Thr Asp Ile Asp Pro 
    290                 295                 300                 


Glu Thr Asn Lys Phe Lys Asp Tyr Ser Asn Ile Trp Asp Lys Thr Ile 
305                 310                 315                 320 


Gly Lys Cys Ser Leu Phe Glu Glu Glu Ile Arg Ala Pro Lys Asn Leu 
                325                 330                 335     


Pro Ser Ala Leu Ile Phe Asn Leu Gln Asn Glu Ile Cys Thr Ile Lys 
            340                 345                 350         


Asn Glu Phe Thr Glu Phe Lys Asn Trp Trp Leu Asn Ala Glu Gln Lys 
        355                 360                 365             


Ser Glu Ile Leu Lys Phe Val Phe Thr Glu Leu Phe Asn Trp Lys Asp 
    370                 375                 380                 


Lys Lys Tyr Ser Asp Lys Lys Phe Asn Lys Asn Leu Gln Asp Lys Ile 
385                 390                 395                 400 


Lys Lys Tyr Leu Leu Asn Phe Ala Leu Glu Asn Phe Asn Leu Asn Glu 
                405                 410                 415     


Glu Ile Leu Lys Asn Arg Asp Leu Glu Asn Asp Thr Val Leu Gly Leu 
            420                 425                 430         


Lys Gly Val Lys Tyr Tyr Glu Lys Ser Asn Ala Thr Ala Asp Ala Ala 
        435                 440                 445             


Leu Glu Phe Ser Ser Leu Lys Pro Leu Tyr Val Phe Ile Lys Phe Leu 
    450                 455                 460                 


Lys Glu Lys Lys Leu Asp Leu Asn Tyr Leu Leu Gly Leu Glu Asn Thr 
465                 470                 475                 480 


Glu Ile Leu Tyr Phe Leu Asp Ser Ile Tyr Leu Ala Ile Ser Tyr Ser 
                485                 490                 495     


Ser Asp Leu Lys Glu Arg Asn Glu Trp Phe Lys Lys Leu Leu Lys Glu 
            500                 505                 510         


Leu Tyr Pro Lys Ile Lys Asn Asn Asn Leu Glu Ile Ile Glu Asn Val 
        515                 520                 525             


Glu Asp Ile Phe Glu Ile Thr Asp Gln Glu Lys Phe Glu Ser Phe Ser 
    530                 535                 540                 


Lys Thr His Ser Leu Ser Arg Glu Ala Phe Asn His Ile Ile Pro Leu 
545                 550                 555                 560 


Leu Leu Ser Asn Asn Glu Gly Lys Asn Tyr Glu Ser Leu Lys His Ser 
                565                 570                 575     


Asn Glu Glu Leu Lys Lys Arg Thr Glu Lys Ala Glu Leu Lys Ala Gln 
            580                 585                 590         


Gln Asn Gln Lys Tyr Leu Lys Asp Asn Phe Leu Lys Glu Ala Leu Val 
        595                 600                 605             


Pro Leu Ser Val Lys Thr Ser Val Leu Gln Ala Ile Lys Ile Phe Asn 
    610                 615                 620                 


Gln Ile Ile Lys Asn Phe Gly Lys Lys Tyr Glu Ile Ser Gln Val Val 
625                 630                 635                 640 


Ile Glu Met Ala Arg Glu Leu Thr Lys Pro Asn Leu Glu Lys Leu Leu 
                645                 650                 655     


Asn Asn Ala Thr Asn Ser Asn Ile Lys Ile Leu Lys Glu Lys Leu Asp 
            660                 665                 670         


Gln Thr Glu Lys Phe Asp Asp Phe Thr Lys Lys Lys Phe Ile Asp Lys 
        675                 680                 685             


Ile Glu Asn Ser Val Val Phe Arg Asn Lys Leu Phe Leu Trp Phe Glu 
    690                 695                 700                 


Gln Asp Arg Lys Asp Pro Tyr Thr Gln Leu Asp Ile Lys Ile Asn Glu 
705                 710                 715                 720 


Ile Glu Asp Glu Thr Glu Ile Asp His Val Ile Pro Tyr Ser Lys Ser 
                725                 730                 735     


Ala Asp Asp Ser Trp Phe Asn Lys Leu Leu Val Lys Lys Ser Thr Asn 
            740                 745                 750         


Gln Leu Lys Lys Asn Lys Thr Val Trp Glu Tyr Tyr Gln Asn Glu Ser 
        755                 760                 765             


Asp Pro Glu Ala Lys Trp Asn Lys Phe Val Ala Trp Ala Lys Arg Ile 
    770                 775                 780                 


Tyr Leu Val Gln Lys Ser Asp Lys Glu Ser Lys Asp Asn Ser Glu Lys 
785                 790                 795                 800 


Asn Ser Ile Phe Lys Asn Lys Lys Pro Asn Leu Lys Phe Lys Asn Ile 
                805                 810                 815     


Thr Lys Lys Leu Phe Asp Pro Tyr Lys Asp Leu Gly Phe Leu Ala Arg 
            820                 825                 830         


Asn Leu Asn Asp Thr Arg Tyr Ala Thr Lys Val Phe Arg Asp Gln Leu 
        835                 840                 845             


Asn Asn Tyr Ser Lys His His Ser Lys Asp Asp Glu Asn Lys Leu Phe 
    850                 855                 860                 


Lys Val Val Cys Met Asn Gly Ser Ile Thr Ser Phe Leu Arg Lys Ser 
865                 870                 875                 880 


Met Trp Arg Lys Asn Glu Glu Gln Val Tyr Arg Phe Asn Phe Trp Lys 
                885                 890                 895     


Lys Asp Arg Asp Gln Phe Phe His His Ala Val Asp Ala Ser Ile Ile 
            900                 905                 910         


Ala Ile Phe Ser Leu Leu Thr Lys Thr Leu Tyr Asn Lys Leu Arg Val 
        915                 920                 925             


Tyr Glu Ser Tyr Asp Val Gln Arg Arg Glu Asp Gly Val Tyr Leu Ile 
    930                 935                 940                 


Asn Lys Glu Thr Gly Glu Val Lys Lys Ala Asp Lys Asp Tyr Trp Lys 
945                 950                 955                 960 


Asp Gln His Asn Phe Leu Lys Ile Arg Glu Asn Ala Ile Glu Ile Lys 
                965                 970                 975     


Asn Val Leu Asn Asn Val Asp Phe Gln Asn Gln Val Arg Tyr Ser Arg 
            980                 985                 990         


Lys Ala Asn Thr Lys Leu Asn Thr  Gln Leu Phe Asn Glu  Thr Leu Tyr 
        995                 1000                 1005             


Gly Val  Lys Glu Phe Glu Asn  Asn Phe Tyr Lys Leu  Glu Lys Val 
    1010                 1015                 1020             


Asn Leu  Phe Ser Arg Lys Asp  Leu Arg Lys Phe Ile  Leu Glu Asp 
    1025                 1030                 1035             


Leu Asn  Glu Glu Ser Glu Lys  Asn Lys Lys Asn Glu  Asn Gly Ser 
    1040                 1045                 1050             


Arg Lys  Arg Ile Leu Thr Glu  Lys Tyr Ile Val Asp  Glu Ile Leu 
    1055                 1060                 1065             


Gln Ile  Leu Glu Asn Glu Glu  Phe Lys Asp Ser Lys  Ser Asp Ile 
    1070                 1075                 1080             


Asn Ala  Leu Asn Lys Tyr Met  Asp Ser Leu Pro Ser  Lys Phe Ser 
    1085                 1090                 1095             


Glu Phe  Phe Ser Gln Asp Phe  Ile Asn Lys Cys Lys  Lys Glu Asn 
    1100                 1105                 1110             


Ser Leu  Ile Leu Thr Phe Asp  Ala Ile Lys His Asn  Asp Pro Lys 
    1115                 1120                 1125             


Lys Val  Ile Lys Ile Lys Asn  Leu Lys Phe Phe Arg  Glu Asp Ala 
    1130                 1135                 1140             


Thr Leu  Lys Asn Lys Gln Ala  Val His Lys Asp Ser  Lys Asn Gln 
    1145                 1150                 1155             


Ile Lys  Ser Phe Tyr Glu Ser  Tyr Lys Cys Val Gly  Phe Ile Trp 
    1160                 1165                 1170             


Leu Lys  Asn Lys Asn Asp Leu  Glu Glu Ser Ile Phe  Val Pro Ile 
    1175                 1180                 1185             


Asn Ser  Arg Val Ile His Phe  Gly Asp Lys Asp Lys  Asp Ile Phe 
    1190                 1195                 1200             


Asp Phe  Asp Ser Tyr Asn Lys  Glu Lys Leu Leu Asn  Glu Ile Asn 
    1205                 1210                 1215             


Leu Lys  Arg Pro Glu Asn Lys  Lys Phe Asn Ser Ile  Asn Glu Ile 
    1220                 1225                 1230             


Glu Phe  Val Lys Phe Val Lys  Pro Gly Ala Leu Leu  Leu Asn Phe 
    1235                 1240                 1245             


Glu Asn  Gln Gln Ile Tyr Tyr  Ile Ser Thr Leu Glu  Ser Ser Ser 
    1250                 1255                 1260             


Leu Arg  Ala Lys Ile Lys Leu  Leu Asn Lys Met Asp  Lys Gly Lys 
    1265                 1270                 1275             


Ala Val  Ser Met Lys Lys Ile  Thr Asn Pro Asp Glu  Tyr Lys Ile 
    1280                 1285                 1290             


Ile Glu  His Val Asn Pro Leu  Gly Ile Asn Leu Asn  Trp Thr Lys 
    1295                 1300                 1305             


Lys Leu  Glu Asn Asn Asn 
    1310                 


<210>  46
<211>  641
<212>  PRT
<213>  Nitrobacter hamburgensis

<400>  46

Met His Lys Arg Asn Ser Arg Ser Tyr Arg Leu Gly Leu Asp Leu Gly 
1               5                   10                  15      


Ser Asn Ser Leu Gly Trp Phe Val Thr His Leu Glu Lys Arg Gly Asp 
            20                  25                  30          


Arg Tyr Glu Pro Val Ala Leu Asp Pro Gly Gly Val Arg Ile Phe Pro 
        35                  40                  45              


Asp Gly Arg Asp Pro Gln Ser Gly Met Ser Asn Ala Val Asp Arg Arg 
    50                  55                  60                  


Met Ala Arg Gly Ala Arg Lys Arg Arg Asp Arg Phe Val Asp Pro Tyr 
65                  70                  75                  80  


Ala Leu Arg Lys Ala Ala Leu Thr Asn Ala Leu Pro Ala His Arg Val 
                85                  90                  95      


Gly Arg Ala Ile Phe His Leu Asn Gln Arg Arg Gly Phe Gln Ser Asn 
            100                 105                 110         


Arg Lys Thr Asp Arg Lys Gln Ser Glu Asp Gly Ala Ile Lys Gln Ala 
        115                 120                 125             


Ala Ser Lys Leu Lys Ala Arg Met His Glu Glu Ala Ala Pro Thr Leu 
    130                 135                 140                 


Gly Ala Phe Phe Ala Asp Met His Leu Arg Lys Ser Tyr Asp Asp Gln 
145                 150                 155                 160 


Gln Thr Ala Ile Arg Ala Glu Leu Val Arg Leu Gly Lys Asp His Leu 
                165                 170                 175     


Thr Gly Asn Ala Arg Lys Lys Val Trp Ala Lys Val Arg Lys Arg Leu 
            180                 185                 190         


Phe Gly Asp Glu Val Leu Arg Pro Lys Asp Thr Ser Asp Gly Ala Arg 
        195                 200                 205             


Ala Arg Ala Thr Thr Thr Gly Thr Lys Ala Ser Tyr Asp Phe Tyr Pro 
    210                 215                 220                 


Thr Arg Ala Met Leu Leu Asp Glu Phe Asn Ala Ile Trp Ala Ala Gln 
225                 230                 235                 240 


Arg Glu His His Leu Ala Met Thr Asp Glu Ala Lys Ala Glu Ile Glu 
                245                 250                 255     


His Ile Ile Phe Tyr His Arg Pro Leu Lys Pro Ala Ile Val Gly Lys 
            260                 265                 270         


Cys Thr Leu Asp Pro Ala Thr Arg Pro Phe Lys Glu Asp Pro Glu Gly 
        275                 280                 285             


Tyr Arg Ala Pro Trp Ser His Pro Leu Ala Gln Arg Phe Arg Ile Leu 
    290                 295                 300                 


Ser Glu Ala Arg Asn Leu Glu Ile Arg Glu Thr Gly Lys Thr Ser Arg 
305                 310                 315                 320 


Arg Leu Thr Lys Asp Gln Ser Asp Leu Val Val Ala Ala Leu Leu Ala 
                325                 330                 335     


Asn Arg Glu Val Lys Phe Asp Lys Leu Arg Thr Leu Leu Lys Leu Pro 
            340                 345                 350         


Ala Glu Ala Arg Phe Asn Leu Glu Ser Asp Arg Arg Ser Thr Ala Thr 
        355                 360                 365             


Arg Pro Pro His Gly Cys Arg Thr Arg Arg Ala Ser Ile Arg Arg Gly 
    370                 375                 380                 


Ala Gly Phe Leu Arg Asn Gly Arg Ser Arg Ser Ser Pro Asp Trp Lys 
385                 390                 395                 400 


Lys Pro Lys Thr Lys Thr Asn Cys Ser His Gly Ser Lys Trp Asn Ala 
                405                 410                 415     


His Leu Thr Ala Gln Arg Pro Arg Ala Ser Pro Ile Arg Arg Cys Arg 
            420                 425                 430         


Thr Ala Ile Ala Gly Ser Ala Cys Ala Gln Ser Lys Arg Ser Cys Arg 
        435                 440                 445             


Ser Cys Arg Thr Ser Ser Met Arg Met Ala Leu Arg Ala Pro Ala Ile 
    450                 455                 460                 


Thr Ser Trp Pro Ser Val Pro Ala Thr Thr Ile Pro Val Asp Thr Phe 
465                 470                 475                 480 


Gln Gln Gly Gly Asn Ala Phe Gly Arg Ile Leu Ser Val Val Thr Ile 
                485                 490                 495     


Glu Leu Phe Ala Ile Thr Asp Arg Val Asp Pro Val Gln Glu Gln Asp 
            500                 505                 510         


Ala Arg Cys Phe Ala Leu Arg Ile Ala Glu Cys Arg Ser Asp Gly Leu 
        515                 520                 525             


Gln His Phe Ala Glu Val Ser Leu Gly Leu Pro Pro Arg Asn Ala Ala 
    530                 535                 540                 


Gln Asp Gln Arg His Ser Ala Gly Leu Cys Gln Ser Ser Cys Val Gly 
545                 550                 555                 560 


Arg Phe Val Pro Gly Thr Pro Cys Arg Arg Thr Pro Arg Ser Thr Ser 
                565                 570                 575     


Leu His Gly Lys Glu Pro Ser Ala His Ala Phe Gly Ser Thr Ala Arg 
            580                 585                 590         


Ser Arg Pro Gln Leu Pro Ala Ser Pro Arg Pro Cys Met Ser Phe Arg 
        595                 600                 605             


Asp Gly Thr Ser Ser Ser Pro Ala Arg Met Pro Glu Thr Leu Asp Arg 
    610                 615                 620                 


Cys Ala Ile Ser Arg Ser Asn Arg Ser Ser Val Cys Arg Ala Glu Arg 
625                 630                 635                 640 


Leu 
    


<210>  47
<211>  1166
<212>  PRT
<213>  Nitrobacter hamburgensis

<400>  47

Met His Val Glu Ile Asp Phe Pro His Phe Ser Arg Gly Asp Ser His 
1               5                   10                  15      


Leu Ala Met Asn Lys Asn Glu Ile Leu Arg Gly Ser Ser Val Leu Tyr 
            20                  25                  30          


Arg Leu Gly Leu Asp Leu Gly Ser Asn Ser Leu Gly Trp Phe Val Thr 
        35                  40                  45              


His Leu Glu Lys Arg Gly Asp Arg His Glu Pro Val Ala Leu Gly Pro 
    50                  55                  60                  


Gly Gly Val Arg Ile Phe Pro Asp Gly Arg Asp Pro Gln Ser Gly Thr 
65                  70                  75                  80  


Ser Asn Ala Val Asp Arg Arg Met Ala Arg Gly Ala Arg Lys Arg Arg 
                85                  90                  95      


Asp Arg Phe Val Glu Arg Arg Lys Glu Leu Ile Ala Ala Leu Ile Lys 
            100                 105                 110         


Tyr Asn Leu Leu Pro Asp Asp Ala Arg Glu Arg Arg Ala Leu Glu Val 
        115                 120                 125             


Leu Asp Pro Tyr Ala Leu Arg Lys Thr Ala Leu Thr Asp Thr Leu Pro 
    130                 135                 140                 


Ala His His Val Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg Gly 
145                 150                 155                 160 


Phe Gln Ser Asn Arg Lys Thr Asp Ser Lys Gln Ser Glu Asp Gly Ala 
                165                 170                 175     


Ile Lys Gln Ala Ala Ser Arg Leu Ala Thr Asp Lys Gly Asn Glu Thr 
            180                 185                 190         


Leu Gly Val Phe Phe Ala Asp Met His Leu Arg Lys Ser Tyr Glu Asp 
        195                 200                 205             


Arg Gln Thr Ala Ile Arg Ala Glu Leu Val Arg Leu Gly Lys Asp His 
    210                 215                 220                 


Leu Thr Gly Asn Ala Arg Lys Lys Ile Trp Ala Lys Val Arg Lys Arg 
225                 230                 235                 240 


Leu Phe Gly Asp Glu Val Leu Pro Arg Ala Asp Ala Pro His Gly Val 
                245                 250                 255     


Arg Ala Arg Ala Thr Ile Thr Gly Thr Lys Ala Ser Tyr Asp Tyr Tyr 
            260                 265                 270         


Pro Thr Arg Asp Met Leu Arg Asp Glu Phe Asn Ala Ile Trp Ala Gly 
        275                 280                 285             


Gln Ser Ala His His Ala Thr Ile Thr Asp Glu Ala Arg Thr Glu Ile 
    290                 295                 300                 


Glu His Ile Ile Phe Tyr Gln Arg Pro Leu Lys Pro Ala Ile Val Gly 
305                 310                 315                 320 


Lys Cys Thr Leu Asp Pro Ala Thr Arg Pro Phe Lys Glu Asp Pro Glu 
                325                 330                 335     


Gly Tyr Arg Ala Pro Trp Ser His Pro Leu Ala Gln Arg Phe Arg Ile 
            340                 345                 350         


Leu Ser Glu Ala Arg Asn Leu Glu Ile Arg Asp Thr Gly Lys Gly Ser 
        355                 360                 365             


Arg Arg Leu Thr Lys Glu Gln Ser Asp Leu Val Val Ala Ala Leu Leu 
    370                 375                 380                 


Ala Asn Arg Glu Val Lys Phe Asp Lys Leu Arg Thr Leu Leu Lys Leu 
385                 390                 395                 400 


Pro Ala Glu Ala Arg Phe Asn Leu Glu Ser Asp Arg Arg Ala Ala Leu 
                405                 410                 415     


Asp Gly Asp Gln Thr Ala Ala Arg Leu Ser Asp Lys Lys Gly Phe Asn 
            420                 425                 430         


Lys Ala Trp Arg Gly Phe Pro Pro Glu Arg Gln Ile Ala Ile Val Ala 
        435                 440                 445             


Arg Leu Glu Glu Thr Glu Asp Glu Asn Glu Leu Ile Ala Trp Leu Glu 
    450                 455                 460                 


Lys Glu Cys Ala Leu Asp Gly Ala Ala Ala Ala Arg Val Ala Asn Thr 
465                 470                 475                 480 


Thr Leu Pro Asp Gly His Cys Arg Leu Gly Leu Arg Ala Ile Lys Lys 
                485                 490                 495     


Ile Val Pro Ile Met Gln Asp Gly Leu Asp Glu Asp Gly Val Ala Gly 
            500                 505                 510         


Ala Gly Tyr His Ile Ala Ala Lys Arg Ala Gly Tyr Asp His Ala Lys 
        515                 520                 525             


Leu Pro Thr Gly Glu Gln Leu Gly Arg Leu Pro Tyr Tyr Gly Gln Trp 
    530                 535                 540                 


Leu Gln Asp Ala Val Val Gly Ser Gly Asp Ala Arg Asp Gln Lys Glu 
545                 550                 555                 560 


Lys Gln Tyr Gly Gln Phe Pro Asn Pro Thr Val His Ile Gly Leu Gly 
                565                 570                 575     


Gln Leu Arg Arg Val Val Asn Asp Leu Ile Asp Lys Tyr Gly Pro Pro 
            580                 585                 590         


Thr Glu Ile Ser Ile Glu Phe Thr Arg Ala Leu Lys Leu Ser Glu Gln 
        595                 600                 605             


Gln Lys Ala Glu Arg Gln Arg Glu Gln Arg Arg Asn Gln Asp Lys Asn 
    610                 615                 620                 


Lys Ala Arg Ala Glu Glu Leu Ala Lys Phe Gly Arg Pro Ala Asn Pro 
625                 630                 635                 640 


Arg Asn Leu Leu Lys Met Arg Leu Trp Glu Glu Leu Ala His Asp Pro 
                645                 650                 655     


Leu Asp Arg Lys Cys Val Tyr Thr Gly Glu Gln Ile Ser Ile Glu Arg 
            660                 665                 670         


Leu Leu Ser Asp Glu Val Asp Ile Asp His Ile Leu Pro Val Ala Met 
        675                 680                 685             


Thr Leu Asp Asp Ser Pro Ala Asn Lys Ile Ile Cys Met Arg Tyr Ala 
    690                 695                 700                 


Asn Arg His Lys Arg Lys Gln Thr Pro Ser Glu Ala Phe Gly Ser Ser 
705                 710                 715                 720 


Pro Thr Leu Gln Gly His Arg Tyr Asn Trp Asp Asp Ile Ala Ala Arg 
                725                 730                 735     


Ala Thr Gly Leu Pro Arg Asn Lys Arg Trp Arg Phe Asp Ala Asn Ala 
            740                 745                 750         


Arg Glu Glu Phe Asp Lys Arg Gly Gly Phe Leu Ala Arg Gln Leu Asn 
        755                 760                 765             


Glu Thr Gly Trp Leu Ala Arg Leu Ala Lys Gln Tyr Leu Gly Ala Val 
    770                 775                 780                 


Thr Asp Pro Asn Gln Ile Trp Val Val Pro Gly Arg Leu Thr Ser Met 
785                 790                 795                 800 


Leu Arg Gly Lys Trp Gly Leu Asn Gly Leu Leu Pro Ser Asp Asn Tyr 
                805                 810                 815     


Ala Gly Val Gln Asp Lys Ala Glu Glu Phe Leu Ala Ser Thr Asp Asp 
            820                 825                 830         


Met Glu Phe Ser Gly Val Lys Asn Arg Ala Asp His Arg His His Ala 
        835                 840                 845             


Ile Asp Gly Leu Val Thr Ala Leu Thr Asp Arg Ser Leu Leu Trp Lys 
    850                 855                 860                 


Met Ala Asn Ala Tyr Asp Glu Glu His Glu Lys Phe Val Ile Glu Pro 
865                 870                 875                 880 


Pro Trp Pro Thr Met Arg Asp Asp Leu Lys Ala Ala Leu Glu Lys Met 
                885                 890                 895     


Val Val Ser His Lys Pro Asp His Gly Ile Glu Gly Lys Leu His Glu 
            900                 905                 910         


Asp Ser Ala Tyr Gly Phe Val Lys Pro Leu Asp Ala Thr Gly Leu Lys 
        915                 920                 925             


Glu Glu Glu Ala Gly Asn Leu Val Tyr Arg Lys Ala Ile Glu Ser Leu 
    930                 935                 940                 


Asn Glu Asn Glu Val Asp Arg Ile Arg Asp Ile Gln Leu Arg Thr Ile 
945                 950                 955                 960 


Val Arg Asp His Val Asn Val Glu Lys Thr Lys Gly Val Ala Leu Ala 
                965                 970                 975     


Asp Ala Leu Arg Gln Leu Gln Ala Pro Ser Asp Asp Tyr Pro Gln Phe 
            980                 985                 990         


Lys His Gly Leu Arg His Val Arg  Ile Leu Lys Lys Glu  Lys Gly Asp 
        995                 1000                 1005             


Tyr Leu  Val Pro Ile Ala Asn  Arg Ala Ser Gly Val  Ala Tyr Lys 
    1010                 1015                 1020             


Ala Tyr  Ser Ala Gly Glu Asn  Phe Cys Val Glu Val  Phe Glu Thr 
    1025                 1030                 1035             


Ala Gly  Gly Lys Trp Asp Gly  Glu Ala Val Arg Arg  Phe Asp Ala 
    1040                 1045                 1050             


Asn Lys  Lys Asn Ala Gly Pro  Lys Ile Ala His Ala  Pro Gln Trp 
    1055                 1060                 1065             


Arg Asp  Ala Asn Glu Gly Ala  Lys Leu Val Met Arg  Ile His Lys 
    1070                 1075                 1080             


Gly Asp  Leu Ile Arg Leu Asp  His Glu Gly Arg Ala  Arg Ile Met 
    1085                 1090                 1095             


Val Val  His Arg Leu Asp Ala  Ala Ala Gly Arg Phe  Lys Leu Ala 
    1100                 1105                 1110             


Asp His  Asn Glu Thr Gly Asn  Leu Asp Lys Arg His  Ala Thr Asn 
    1115                 1120                 1125             


Asn Asp  Ile Asp Pro Phe Arg  Trp Leu Met Ala Ser  Tyr Asn Thr 
    1130                 1135                 1140             


Leu Lys  Lys Leu Ala Ala Val  Pro Val Arg Val Asp  Glu Leu Gly 
    1145                 1150                 1155             


Arg Val  Trp Arg Val Met Pro  Asn 
    1160                 1165     


<210>  48
<211>  1082
<212>  PRT
<213>  Neisseria meningitidis Z2491

<400>  48

Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  49
<211>  1082
<212>  PRT
<213>  Neisseria meningitidis

<400>  49

Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Val Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  50
<211>  1037
<212>  PRT
<213>  Parvibaculum lavamentivorans

<400>  50

Met Glu Arg Ile Phe Gly Phe Asp Ile Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ser Val Ile Asp Tyr Ser Ser Thr Gln Ser Ala Gly Asn Ile Gln Arg 
            20                  25                  30          


Leu Gly Val Arg Ile Phe Pro Glu Ala Arg Asp Pro Asp Gly Thr Pro 
        35                  40                  45              


Leu Asn Gln Gln Arg Arg Gln Lys Arg Met Met Arg Arg Gln Leu Arg 
    50                  55                  60                  


Arg Arg Arg Ile Arg Arg Lys Ala Leu Asn Glu Thr Leu His Glu Ala 
65                  70                  75                  80  


Gly Phe Leu Pro Ala Tyr Gly Ser Ala Asp Trp Pro Val Val Met Ala 
                85                  90                  95      


Asp Glu Pro Tyr Glu Leu Arg Arg Arg Gly Leu Glu Glu Gly Leu Ser 
            100                 105                 110         


Ala Tyr Glu Phe Gly Arg Ala Ile Tyr His Leu Ala Gln His Arg His 
        115                 120                 125             


Phe Lys Gly Arg Glu Leu Glu Glu Ser Asp Thr Pro Asp Pro Asp Val 
    130                 135                 140                 


Asp Asp Glu Lys Glu Ala Ala Asn Glu Arg Ala Ala Thr Leu Lys Ala 
145                 150                 155                 160 


Leu Lys Asn Glu Gln Thr Thr Leu Gly Ala Trp Leu Ala Arg Arg Pro 
                165                 170                 175     


Pro Ser Asp Arg Lys Arg Gly Ile His Ala His Arg Asn Val Val Ala 
            180                 185                 190         


Glu Glu Phe Glu Arg Leu Trp Glu Val Gln Ser Lys Phe His Pro Ala 
        195                 200                 205             


Leu Lys Ser Glu Glu Met Arg Ala Arg Ile Ser Asp Thr Ile Phe Ala 
    210                 215                 220                 


Gln Arg Pro Val Phe Trp Arg Lys Asn Thr Leu Gly Glu Cys Arg Phe 
225                 230                 235                 240 


Met Pro Gly Glu Pro Leu Cys Pro Lys Gly Ser Trp Leu Ser Gln Gln 
                245                 250                 255     


Arg Arg Met Leu Glu Lys Leu Asn Asn Leu Ala Ile Ala Gly Gly Asn 
            260                 265                 270         


Ala Arg Pro Leu Asp Ala Glu Glu Arg Asp Ala Ile Leu Ser Lys Leu 
        275                 280                 285             


Gln Gln Gln Ala Ser Met Ser Trp Pro Gly Val Arg Ser Ala Leu Lys 
    290                 295                 300                 


Ala Leu Tyr Lys Gln Arg Gly Glu Pro Gly Ala Glu Lys Ser Leu Lys 
305                 310                 315                 320 


Phe Asn Leu Glu Leu Gly Gly Glu Ser Lys Leu Leu Gly Asn Ala Leu 
                325                 330                 335     


Glu Ala Lys Leu Ala Asp Met Phe Gly Pro Asp Trp Pro Ala His Pro 
            340                 345                 350         


Arg Lys Gln Glu Ile Arg His Ala Val His Glu Arg Leu Trp Ala Ala 
        355                 360                 365             


Asp Tyr Gly Glu Thr Pro Asp Lys Lys Arg Val Ile Ile Leu Ser Glu 
    370                 375                 380                 


Lys Asp Arg Lys Ala His Arg Glu Ala Ala Ala Asn Ser Phe Val Ala 
385                 390                 395                 400 


Asp Phe Gly Ile Thr Gly Glu Gln Ala Ala Gln Leu Gln Ala Leu Lys 
                405                 410                 415     


Leu Pro Thr Gly Trp Glu Pro Tyr Ser Ile Pro Ala Leu Asn Leu Phe 
            420                 425                 430         


Leu Ala Glu Leu Glu Lys Gly Glu Arg Phe Gly Ala Leu Val Asn Gly 
        435                 440                 445             


Pro Asp Trp Glu Gly Trp Arg Arg Thr Asn Phe Pro His Arg Asn Gln 
    450                 455                 460                 


Pro Thr Gly Glu Ile Leu Asp Lys Leu Pro Ser Pro Ala Ser Lys Glu 
465                 470                 475                 480 


Glu Arg Glu Arg Ile Ser Gln Leu Arg Asn Pro Thr Val Val Arg Thr 
                485                 490                 495     


Gln Asn Glu Leu Arg Lys Val Val Asn Asn Leu Ile Gly Leu Tyr Gly 
            500                 505                 510         


Lys Pro Asp Arg Ile Arg Ile Glu Val Gly Arg Asp Val Gly Lys Ser 
        515                 520                 525             


Lys Arg Glu Arg Glu Glu Ile Gln Ser Gly Ile Arg Arg Asn Glu Lys 
    530                 535                 540                 


Gln Arg Lys Lys Ala Thr Glu Asp Leu Ile Lys Asn Gly Ile Ala Asn 
545                 550                 555                 560 


Pro Ser Arg Asp Asp Val Glu Lys Trp Ile Leu Trp Lys Glu Gly Gln 
                565                 570                 575     


Glu Arg Cys Pro Tyr Thr Gly Asp Gln Ile Gly Phe Asn Ala Leu Phe 
            580                 585                 590         


Arg Glu Gly Arg Tyr Glu Val Glu His Ile Trp Pro Arg Ser Arg Ser 
        595                 600                 605             


Phe Asp Asn Ser Pro Arg Asn Lys Thr Leu Cys Arg Lys Asp Val Asn 
    610                 615                 620                 


Ile Glu Lys Gly Asn Arg Met Pro Phe Glu Ala Phe Gly His Asp Glu 
625                 630                 635                 640 


Asp Arg Trp Ser Ala Ile Gln Ile Arg Leu Gln Gly Met Val Ser Ala 
                645                 650                 655     


Lys Gly Gly Thr Gly Met Ser Pro Gly Lys Val Lys Arg Phe Leu Ala 
            660                 665                 670         


Lys Thr Met Pro Glu Asp Phe Ala Ala Arg Gln Leu Asn Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ala Lys Gln Ile Leu Ala Gln Leu Lys Arg Leu Trp Pro Asp 
    690                 695                 700                 


Met Gly Pro Glu Ala Pro Val Lys Val Glu Ala Val Thr Gly Gln Val 
705                 710                 715                 720 


Thr Ala Gln Leu Arg Lys Leu Trp Thr Leu Asn Asn Ile Leu Ala Asp 
                725                 730                 735     


Asp Gly Glu Lys Thr Arg Ala Asp His Arg His His Ala Ile Asp Ala 
            740                 745                 750         


Leu Thr Val Ala Cys Thr His Pro Gly Met Thr Asn Lys Leu Ser Arg 
        755                 760                 765             


Tyr Trp Gln Leu Arg Asp Asp Pro Arg Ala Glu Lys Pro Ala Leu Thr 
    770                 775                 780                 


Pro Pro Trp Asp Thr Ile Arg Ala Asp Ala Glu Lys Ala Val Ser Glu 
785                 790                 795                 800 


Ile Val Val Ser His Arg Val Arg Lys Lys Val Ser Gly Pro Leu His 
                805                 810                 815     


Lys Glu Thr Thr Tyr Gly Asp Thr Gly Thr Asp Ile Lys Thr Lys Ser 
            820                 825                 830         


Gly Thr Tyr Arg Gln Phe Val Thr Arg Lys Lys Ile Glu Ser Leu Ser 
        835                 840                 845             


Lys Gly Glu Leu Asp Glu Ile Arg Asp Pro Arg Ile Lys Glu Ile Val 
    850                 855                 860                 


Ala Ala His Val Ala Gly Arg Gly Gly Asp Pro Lys Lys Ala Phe Pro 
865                 870                 875                 880 


Pro Tyr Pro Cys Val Ser Pro Gly Gly Pro Glu Ile Arg Lys Val Arg 
                885                 890                 895     


Leu Thr Ser Lys Gln Gln Leu Asn Leu Met Ala Gln Thr Gly Asn Gly 
            900                 905                 910         


Tyr Ala Asp Leu Gly Ser Asn His His Ile Ala Ile Tyr Arg Leu Pro 
        915                 920                 925             


Asp Gly Lys Ala Asp Phe Glu Ile Val Ser Leu Phe Asp Ala Ser Arg 
    930                 935                 940                 


Arg Leu Ala Gln Arg Asn Pro Ile Val Gln Arg Thr Arg Ala Asp Gly 
945                 950                 955                 960 


Ala Ser Phe Val Met Ser Leu Ala Ala Gly Glu Ala Ile Met Ile Pro 
                965                 970                 975     


Glu Gly Ser Lys Lys Gly Ile Trp Ile Val Gln Gly Val Trp Ala Ser 
            980                 985                 990         


Gly Gln Val Val Leu Glu Arg Asp  Thr Asp Ala Asp His  Ser Thr Thr 
        995                 1000                 1005             


Thr Arg  Pro Met Pro Asn Pro  Ile Leu Lys Asp Asp  Ala Lys Lys 
    1010                 1015                 1020             


Val Ser  Ile Asp Pro Ile Gly  Arg Val Arg Pro Ser  Asn Asp 
    1025                 1030                 1035         


<210>  51
<211>  1056
<212>  PRT
<213>  Pasteurella multocida

<400>  51

Met Gln Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 
            20                  25                  30          


Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Thr Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Leu Ala Lys 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Ile Asp Leu Glu Lys 
                85                  90                  95      


Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 
            100                 105                 110         


Arg Leu Ser Ala Ile Glu Trp Gly Ala Val Leu Leu His Leu Ile Lys 
        115                 120                 125             


His Arg Gly Tyr Leu Ser Lys Arg Lys Asn Glu Ser Gln Thr Asn Asn 
    130                 135                 140                 


Lys Glu Leu Gly Ala Leu Leu Ser Gly Val Ala Gln Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Ser Asp Asp Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr 
            180                 185                 190         


His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 
        195                 200                 205             


Ala Gln Gln His Gln Phe Gly Asn Pro His Cys Lys Glu His Ile Gln 
    210                 215                 220                 


Gln Tyr Met Thr Glu Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 
                245                 250                 255     


Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 
            260                 265                 270         


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 
        275                 280                 285             


Leu Asn Glu Glu Glu Arg Gln Leu Leu Ile Asn His Pro Tyr Glu Lys 
    290                 295                 300                 


Ser Lys Leu Thr Tyr Ala Gln Val Arg Lys Leu Leu Gly Leu Ser Glu 
305                 310                 315                 320 


Gln Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Asn Ala Glu Ser 
                325                 330                 335     


Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 
            340                 345                 350         


Glu Asn Gln Gly Leu Lys Asp Thr Trp Gln Asp Leu Ala Lys Lys Pro 
        355                 360                 365             


Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Gln Gln Tyr Leu Thr Asn Lys Val Pro Asn Ser Val Ile 
385                 390                 395                 400 


Asn Ala Leu Leu Val Ser Leu Asn Phe Asp Lys Phe Ile Glu Leu Ser 
                405                 410                 415     


Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Lys Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys Arg Glu Ile Tyr Gly His His Tyr Gly Glu Ala 
        435                 440                 445             


Asn Gln Lys Thr Ser Gln Leu Leu Pro Ala Ile Pro Ala Gln Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Ala Ile Ile Arg Gln Tyr Gly Ser Pro Ala Arg Val His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gln 
            500                 505                 510         


Lys Gln Gln Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gln Lys 
        515                 520                 525             


Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 
    530                 535                 540                 


Ile Leu Lys Phe Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Gln Thr Pro Tyr Glu Trp Leu Gln Gly Lys Ile Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gln Cys Ser Ala Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Leu Leu Thr Gln Val Ile Asp Asp Asn Lys Phe Ile Asp 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 
            660                 665                 670         


Ile Gln Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 
        675                 680                 685             


Thr Pro Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 
    690                 695                 700                 


Ile Lys Ala Arg Glu Asn Asn Asn Arg His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Val Val Ala Cys Ala Thr Pro Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 
            740                 745                 750         


Met Val Asp Gln Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 
        755                 760                 765             


Pro Trp Ala Tyr Phe Arg Gln Glu Val Asn Ile Arg Val Phe Asp Asn 
    770                 775                 780                 


His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gln Ala 
785                 790                 795                 800 


Asn His Gln Phe Val Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 
                805                 810                 815     


Lys Met Ser Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 
            820                 825                 830         


Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gln Leu Lys 
        835                 840                 845             


Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 
    850                 855                 860                 


Tyr Ala Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gln Asp Pro Ala 
865                 870                 875                 880 


Lys Ala Phe Ala Thr Pro Phe Tyr Lys Gln Gly Gly Gln Gln Val Lys 
                885                 890                 895     


Ala Ile Arg Val Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Glu 
            900                 905                 910         


Asn Asn Gly Val Ala Asp Asn Ala Ser Ile Val Arg Thr Asp Val Phe 
        915                 920                 925             


Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp Gln Val 
    930                 935                 940                 


Ala Lys Gly Ile Leu Pro Asn Lys Ala Ile Val Ala His Lys Asn Glu 
945                 950                 955                 960 


Asp Glu Trp Glu Glu Met Asp Glu Gly Ala Lys Phe Lys Phe Ser Leu 
                965                 970                 975     


Phe Pro Asn Asp Leu Val Glu Leu Lys Thr Lys Lys Glu Tyr Phe Phe 
            980                 985                 990         


Gly Tyr Tyr Ile Gly Leu Asp Arg  Ala Thr Gly Asn Ile  Ser Leu Lys 
        995                 1000                 1005             


Glu His  Asp Gly Glu Ile Ser  Lys Gly Lys Asp Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Val Lys Leu Ala Leu  Ser Phe Glu Lys Tyr  Gln Val Asp 
    1025                 1030                 1035             


Glu Leu  Gly Lys Asn Arg Gln  Ile Cys Arg Pro Gln  Gln Arg Gln 
    1040                 1045                 1050             


Pro Val  Arg 
    1055     


<210>  52
<211>  1066
<212>  PRT
<213>  Rhodopseudomonas palustris BisB18

<400>  52

Met Ser Glu Arg Val Val Arg Arg Ile Leu Gly Ile Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Cys Gly Trp Gly Val Val Asp Ile Ser Gly Ala Gly Gly Gly 
            20                  25                  30          


Ile Ile Ala Thr Gly Val Arg Cys Phe Asp Ala Pro Leu Ile Asp Lys 
        35                  40                  45              


Thr Gly Glu Pro Lys Ser Ala Thr Arg Arg Thr Ala Arg Gly Gln Arg 
    50                  55                  60                  


Arg Ile Val Arg Arg Arg Arg Gln Arg Met Asn Gly Val Arg Arg Leu 
65                  70                  75                  80  


Leu Cys Glu Phe Gly Leu Leu Pro Asp Pro Arg Pro Asp Ala Leu Asn 
                85                  90                  95      


Gln Ala Met Arg Arg Ile Ser Thr Ala Ser Ala Ala Ala Gln Val Thr 
            100                 105                 110         


Pro Trp Thr Leu Arg Ala Ala Ala His Gln Arg Leu Leu Ser Asn Glu 
        115                 120                 125             


Glu Leu Ala Val Val Leu Gly His Ile Ala Arg His Arg Gly Phe Arg 
    130                 135                 140                 


Ser Asn Ala Lys Asn Glu Ala Gly Ala Asn Ala Ala Asp Glu Thr Ser 
145                 150                 155                 160 


Lys Met Lys Lys Ala Met Glu Ala Thr Arg Glu Gly Leu Ala Lys Tyr 
                165                 170                 175     


His Ala Phe Gly Asp Met Ile Ala Asn Asp Pro Lys Phe Ala Asn Arg 
            180                 185                 190         


Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 
        195                 200                 205             


Leu Glu Asp Glu Val Arg Ala Ile Leu Arg Ala Gln Leu Arg Phe Gly 
    210                 215                 220                 


Ser Ala Ala Ala Thr Glu Thr Leu Ala Gln Thr Phe Ala Asp Val Ala 
225                 230                 235                 240 


Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Asp Arg Val Gly Asp Cys 
                245                 250                 255     


Pro Phe Glu Pro Gly Gln Lys Arg Ala Ala Arg Arg Ala Pro Ser Phe 
            260                 265                 270         


Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Ala Val 
        275                 280                 285             


Gly Arg Ser Pro Glu Arg Arg Leu Thr Ala Glu Glu Ile Ala Leu Ala 
    290                 295                 300                 


Ala Lys Gly Phe Gly Glu Thr Lys Lys Thr Ile Thr Phe Lys Ser Leu 
305                 310                 315                 320 


Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Ile Gly 
                325                 330                 335     


Lys Asp Lys Glu Ala Ser Leu Asp Val Val Ala Arg Thr Gly Gly Ala 
            340                 345                 350         


Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 
        355                 360                 365             


Arg Ser Leu Ser Arg Thr Pro Glu Thr Leu Asp Arg Ile Ala Glu Ile 
    370                 375                 380                 


Leu Ser Phe Arg Glu Asp Ile Thr Ser Ile Arg Asn Gly Leu Glu Asp 
385                 390                 395                 400 


Leu Gly Leu Asp Ser Leu Val Val Glu Ala Leu Met Gln Ala Ala Ala 
                405                 410                 415     


Asn Gly Asp Phe Lys Glu Phe Thr Arg Ala Gly His Ile Ser Ala Arg 
            420                 425                 430         


Ala Ala Arg Asn Ile Ile Pro Gly Leu Arg Glu Gly Leu Val Tyr Ser 
        435                 440                 445             


Glu Ala Cys Ala Arg Val Gly Tyr Asp His Ala Ala Arg Leu Ser Val 
    450                 455                 460                 


Pro Leu Asp Gln Val Gly Ser Pro Val Thr Arg Lys Ala Leu Ser Glu 
465                 470                 475                 480 


Ala Leu Lys Gln Val Arg Ala Val Ala Arg Glu Tyr Gly Pro Ile Asp 
                485                 490                 495     


Tyr Phe His Ile Glu Leu Ala Arg Ser Val Gly Lys Ser Ala Glu Glu 
            500                 505                 510         


Arg Lys Gln Leu Thr Asp Gly Ile Glu Ala Arg Asn Val Glu Lys Ala 
        515                 520                 525             


Lys Arg Arg Lys Gln Ala Glu Glu His Leu Gly Arg Ala Pro Ser Asp 
    530                 535                 540                 


Asp Glu Leu Leu Arg Tyr Glu Leu Ala Lys Glu Gln Asn Phe Lys Cys 
545                 550                 555                 560 


Ile Tyr Ser Gly Asp Ala Ile Asp Pro Ala Gly Val Ala Ala Asn Asp 
                565                 570                 575     


Thr Arg Tyr Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
            580                 585                 590         


Asp Ser Tyr Leu Asn Lys Thr Leu Cys Thr Ala Arg Ser Asn Gln Asn 
        595                 600                 605             


Lys Arg Gly Arg Thr Pro Phe Glu Trp Phe Glu Ala Asp Lys Thr Asp 
    610                 615                 620                 


Val Glu Trp Met Glu Tyr Val Ala Arg Val Glu Asn Leu Gln Glu Val 
625                 630                 635                 640 


Lys Gly Arg Lys Lys Arg Asn Tyr Ser Ile Lys Asp Ala Ala Ala Ile 
                645                 650                 655     


Glu Asp Lys Phe Lys Ala Arg Asn Leu Thr Asp Thr Gln Trp Ala Thr 
            660                 665                 670         


Arg Leu Leu Ala Asp Glu Leu Ser Arg Met Phe Pro Pro Arg Glu Cys 
        675                 680                 685             


Glu Arg Ala Ile Cys Gly Arg Ala Asp Gly Gly Asn Asp Gly Leu Thr 
    690                 695                 700                 


Ile Val Glu Glu Arg Arg Val Phe Thr Arg Pro Gly Ala Ile Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Arg Ala Trp Gly Leu Glu Gly Leu Lys Lys Gln Asp Gly 
                725                 730                 735     


Lys Arg Val Glu Asp Asp Arg His His Ala Val Asp Ala Leu Val Leu 
            740                 745                 750         


Ala Ala Thr Thr Glu Ser Leu Leu Gln Arg Leu Thr Val Glu Val Gln 
        755                 760                 765             


Arg Arg Glu Arg Glu Gly Arg Pro Asp Asp Ile Phe His Cys Ala Glu 
    770                 775                 780                 


Pro Trp Arg Gly Phe Arg Ala Asp Val Arg Arg Thr Val Tyr Gly Ser 
785                 790                 795                 800 


Glu Thr Met Pro Gly Ile Phe Val Ser Arg Ala Glu Arg Arg Arg Ala 
                805                 810                 815     


Arg Gly Lys Ala His Asp Ala Thr Ile Lys Gln Ile Arg Glu Ile Glu 
            820                 825                 830         


Gly Glu Arg Leu Val Phe Glu Arg Lys Pro Val Glu Lys Leu Thr Asp 
        835                 840                 845             


Lys Asp Leu Glu Lys Ile Pro Ile Pro Lys Pro Tyr Gly Gln Val Ser 
    850                 855                 860                 


Asp Pro Lys Arg Leu Arg Asp Glu Leu Val Glu Ser Leu Arg Ala Trp 
865                 870                 875                 880 


Ile Ala Ala Gly Lys Pro Lys Asp Arg Pro Pro Leu Ser Pro Lys Gly 
                885                 890                 895     


Asp Val Ile Arg Lys Val Arg Ile Gln Thr Asn Asp Lys Val Ser Val 
            900                 905                 910         


Glu Ile Asn Gly Gly Thr Val Asp Arg Gly Asp Met Ala Arg Val Asp 
        915                 920                 925             


Val Phe Arg Lys Lys Asn Lys Lys Ala Val Trp Glu Tyr Tyr Val Val 
    930                 935                 940                 


Pro Ile Tyr Pro His Gln Ile Val Ala Leu Asn Asp Pro Pro Asp Arg 
945                 950                 955                 960 


Ala Val Ile Ala Tyr Ala Glu Asp Lys Asp Trp Lys Glu Ile Asp Ser 
                965                 970                 975     


Ser Tyr Glu Phe Leu Trp Ser Leu Phe Gly Leu Ser Tyr Val Glu Ile 
            980                 985                 990         


Ser Lys Ala Asn Gly Glu Cys Ile  Asp Gly Tyr Phe Arg  Gly Leu His 
        995                 1000                 1005             


Arg Gly  Thr Gly Ala Ala Ser  Val Cys Lys His Ile  Ser Leu Gly 
    1010                 1015                 1020             


Lys Asp  Ala Thr Val Ser Gly  Ile Gly Leu Lys Thr  Leu Ala Ser 
    1025                 1030                 1035             


Phe Lys  Lys Phe Thr Ile Asp  Arg Leu Gly Arg Lys  Phe Glu Ile 
    1040                 1045                 1050             


Pro Arg  Glu Val Arg Thr Trp  Arg Gly Glu Ala Cys  Thr 
    1055                 1060                 1065     


<210>  53
<211>  1064
<212>  PRT
<213>  Rhodopseudomonas palustris BisB5

<400>  53

Met Ser Glu Cys Val Thr Arg Arg Ile Leu Gly Ile Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Cys Gly Trp Gly Val Ile Glu Val Gly Glu Ala Ser Gly Ser 
            20                  25                  30          


Ile Ile Ala Ser Gly Val Arg Cys Phe Asp Ala Pro Leu Ile Asp Lys 
        35                  40                  45              


Thr Gly Glu Pro Lys Ser Ala Thr Arg Arg Thr Ala Arg Gly Gln Arg 
    50                  55                  60                  


Arg Ile Ile Arg Arg Arg Arg Gln Arg Met Asn Ala Val Arg Arg Leu 
65                  70                  75                  80  


Leu Ala Glu Phe Gly Val Leu Thr Gly Arg Ser Pro Asp Ala Leu His 
                85                  90                  95      


Gln Ala Leu Leu Arg Leu Ser Gln Ser Val Ala Gly Ser Gln Val Thr 
            100                 105                 110         


Pro Trp Thr Leu Arg Ala Ala Ala His Glu Arg Lys Leu Thr Asn Asp 
        115                 120                 125             


Glu Leu Ala Val Val Leu Gly His Ile Ala Arg His Arg Gly Phe Arg 
    130                 135                 140                 


Ser Asn Ser Lys Asn Asp Gly Gly Ala Asn Ala Ala Asp Glu Thr Ser 
145                 150                 155                 160 


Lys Met Lys Lys Ala Met Glu Thr Thr Arg Glu Gly Leu Ala Arg Tyr 
                165                 170                 175     


His Ser Phe Gly Ala Met Ile Ala Ser Asp Pro Lys Phe Ala Asp Arg 
            180                 185                 190         


Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 
        195                 200                 205             


Leu Glu Asp Glu Val Arg Thr Ile Phe Arg Ser Gln Thr Arg Phe Gly 
    210                 215                 220                 


Ser Leu Val Ala Ser Glu Lys Leu Ser Gln Ala Phe Ala Asp Ala Ala 
225                 230                 235                 240 


Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Asp Met Val Gly Ser Cys 
                245                 250                 255     


Pro Phe Glu Pro Gly Gln Lys Arg Thr Ala Arg Arg Ala Pro Ser Phe 
            260                 265                 270         


Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Thr Val 
        275                 280                 285             


Gly Arg Ala Pro Glu Arg Arg Leu Thr Pro Asp Glu Ile Ala Leu Ala 
    290                 295                 300                 


Ala Lys Gly Phe Gly Glu Thr Lys Lys Ser Ile Thr Phe Lys Ser Leu 
305                 310                 315                 320 


Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Val Ala 
                325                 330                 335     


Lys Glu Lys Glu Ser Thr Leu Asp Val Ala Ala Arg Thr Gly Gly Ala 
            340                 345                 350         


Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 
        355                 360                 365             


Arg Ser Leu Ser Arg Met Pro Glu Lys Leu Asp Arg Ile Ala Glu Ile 
    370                 375                 380                 


Leu Ser Phe Arg Glu Asp Met Lys Ala Ile Arg Asn Gly Leu Glu Glu 
385                 390                 395                 400 


Val Gly Leu Asp Gly Leu Val Val Asp Ala Leu Met Gln Ala Thr Ala 
                405                 410                 415     


Asn Gly Asp Phe Lys Asp Phe Thr Arg Ala Ala His Ile Ser Ala Leu 
            420                 425                 430         


Ala Ala Arg Asn Ile Ile Pro Gly Leu Arg Glu Gly Leu Val Tyr Ser 
        435                 440                 445             


Asp Ala Cys Thr Arg Val Gly Tyr Asp His Ala Ala Arg Pro Ala Val 
    450                 455                 460                 


Pro Leu Ser Gln Ile Gly Ser Pro Val Thr Arg Lys Ala Leu Ser Glu 
465                 470                 475                 480 


Ala Leu Lys Gln Val Arg Ala Val Ala Arg Glu Tyr Gly Pro Ile Asp 
                485                 490                 495     


Tyr Phe His Ile Glu Leu Ala Arg Ser Ile Gly Lys Ser Ala Glu Glu 
            500                 505                 510         


Arg Lys Lys Leu Thr Asp Gly Ile Glu Ala Arg Asn Val Glu Lys Glu 
        515                 520                 525             


Lys Arg Arg Lys Glu Ala Ala Glu His Leu Gly Arg Ala Pro Ser Asp 
    530                 535                 540                 


Asp Glu Leu Leu Arg Tyr Glu Leu Ala Lys Glu Gln Asn Phe Lys Cys 
545                 550                 555                 560 


Ile Tyr Ser Gly Asp Pro Ile Asp Pro Ala Gly Ile Ser Ala Asn Asp 
                565                 570                 575     


Thr Arg Tyr Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
            580                 585                 590         


Asp Ser Tyr Val Asn Lys Thr Leu Cys Thr Ala Arg Ser Asn Gln Asn 
        595                 600                 605             


Lys Arg Gly Arg Thr Pro Phe Glu Trp Phe Asp Ala Asp Lys Thr Glu 
    610                 615                 620                 


Ala Glu Trp Met Glu Tyr Ser Ala Arg Val Glu Asp Leu Lys Glu Val 
625                 630                 635                 640 


Lys Gly Arg Lys Lys Arg Asn Tyr Ser Ile Lys Asp Ala Ala Ser Val 
                645                 650                 655     


Glu Asp Lys Phe Lys Ala Arg Asn Leu Thr Asp Thr Gln Trp Ala Thr 
            660                 665                 670         


Arg Leu Leu Ala Asp Glu Leu Lys Arg Met Phe Pro Pro Arg Glu Cys 
        675                 680                 685             


Glu Arg Val Val Thr Val Arg Ala Asp Gly Gly Asn Asp Gly Leu Ser 
    690                 695                 700                 


Ile Val Glu Glu Arg Arg Val Phe Thr Arg Pro Gly Ala Ile Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Arg Ala Trp Gly Leu Glu Gly Leu Lys Lys Gln Asp Gly 
                725                 730                 735     


Lys Arg Val Glu Asp Asp Arg His His Ala Val Asp Ala Leu Val Leu 
            740                 745                 750         


Ala Ala Thr Thr Glu Ser Leu Leu Asn Arg Leu Thr Val Glu Val Gln 
        755                 760                 765             


Gln Arg Glu Arg Glu Gly Arg Gln Asp Asp Ile Phe His Cys Ser Gln 
    770                 775                 780                 


Pro Trp Pro Gly Phe Arg Val Asp Val Gln Arg Thr Val Tyr Gly Ser 
785                 790                 795                 800 


Glu Thr Met Pro Gly Ile Phe Val Ser Arg Ala Glu Arg Arg Arg Ala 
                805                 810                 815     


Arg Gly Lys Ala His Asp Ala Thr Val Lys Gln Ile Arg Asp Ile Asp 
            820                 825                 830         


Gly Glu Arg Ile Val Phe Glu Arg Lys Pro Ile Glu Lys Leu Thr Asp 
        835                 840                 845             


Lys Asp Leu Glu Arg Ile Pro Val Pro Glu Pro Tyr Gly Lys Ala Ala 
    850                 855                 860                 


Asp Pro Lys Lys Leu Arg Asp Glu Leu Val Glu Asn Leu Arg Ala Trp 
865                 870                 875                 880 


Ile Ala Ala Gly Lys Pro Lys Asp Lys Pro Pro Arg Ser Pro Lys Gly 
                885                 890                 895     


Asp Ile Ile Arg Lys Val Arg Ile Glu Thr Lys Asp Lys Val Ala Val 
            900                 905                 910         


Glu Ile Asn Gly Gly Thr Val Asp Arg Gly Asp Met Ala Arg Val Asp 
        915                 920                 925             


Val Phe Arg Lys Lys Asn Lys Lys Gly Val Trp Glu Phe Tyr Val Ile 
    930                 935                 940                 


Pro Ile Tyr Pro His Gln Ile Val Ala Ser Ala Leu Pro Pro Asn Arg 
945                 950                 955                 960 


Ala Val Ile Ala Tyr Lys Ala Glu Ser Glu Trp Thr Ala Ile Asp Gly 
                965                 970                 975     


Cys Phe Glu Phe Ala Trp Ser Leu Asn Pro Met Ser Tyr Leu Glu Leu 
            980                 985                 990         


Val Lys Ser Asn Gly Glu Leu Ile  Glu Gly Tyr Phe Arg  Ser Met Asp 
        995                 1000                 1005             


Arg Thr  Thr Gly Ala Ile Asn  Leu Ser Pro Met Ser  Thr Asn Ser 
    1010                 1015                 1020             


Glu Thr  Ile Arg Ser Ile Gly  Val Lys Thr Leu Ser  Ser Phe Arg 
    1025                 1030                 1035             


Lys Phe  Thr Val Asp Arg Leu  Gly Arg Lys Phe Glu  Ile Pro Arg 
    1040                 1045                 1050             


Glu Val  Arg Thr Trp Arg Gly  Glu Ala Cys Thr 
    1055                 1060                 


<210>  54
<211>  1173
<212>  PRT
<213>  Rhodospirillum rubrum

<400>  54

Met Arg Pro Ile Glu Pro Trp Ile Leu Gly Leu Asp Ile Gly Thr Asp 
1               5                   10                  15      


Ser Leu Gly Trp Ala Val Phe Ser Cys Glu Glu Lys Gly Pro Pro Thr 
            20                  25                  30          


Ala Lys Glu Leu Leu Gly Gly Gly Val Arg Leu Phe Asp Ser Gly Arg 
        35                  40                  45              


Asp Ala Lys Asp His Thr Ser Arg Gln Ala Glu Arg Gly Ala Phe Arg 
    50                  55                  60                  


Arg Ala Arg Arg Gln Thr Arg Thr Trp Pro Trp Arg Arg Asp Arg Leu 
65                  70                  75                  80  


Ile Ala Leu Phe Gln Ala Ala Gly Leu Thr Pro Pro Ala Ala Glu Thr 
                85                  90                  95      


Arg Gln Ile Ala Leu Ala Leu Arg Arg Glu Ala Val Ser Arg Pro Leu 
            100                 105                 110         


Ala Pro Asp Ala Leu Trp Ala Ala Leu Leu His Leu Ala His His Arg 
        115                 120                 125             


Gly Phe Arg Ser Asn Arg Ile Asp Lys Arg Glu Arg Ala Ala Ala Lys 
    130                 135                 140                 


Ala Leu Ala Lys Ala Lys Pro Ala Lys Ala Thr Ala Lys Ala Thr Ala 
145                 150                 155                 160 


Pro Ala Lys Glu Ala Asp Asp Glu Ala Gly Phe Trp Glu Gly Ala Glu 
                165                 170                 175     


Ala Ala Leu Arg Gln Arg Met Ala Ala Ser Gly Ala Pro Thr Val Gly 
            180                 185                 190         


Ala Leu Leu Ala Asp Asp Leu Asp Arg Gly Gln Pro Val Arg Met Arg 
        195                 200                 205             


Tyr Asn Gln Ser Asp Arg Asp Gly Val Val Ala Pro Thr Arg Ala Leu 
    210                 215                 220                 


Ile Ala Glu Glu Leu Ala Glu Ile Val Ala Arg Gln Ser Ser Ala Tyr 
225                 230                 235                 240 


Pro Gly Leu Asp Trp Pro Ala Val Thr Arg Leu Val Leu Asp Gln Arg 
                245                 250                 255     


Pro Leu Arg Ser Lys Gly Ala Gly Pro Cys Ala Phe Leu Pro Gly Glu 
            260                 265                 270         


Asp Arg Ala Leu Arg Ala Leu Pro Thr Val Gln Asp Phe Ile Ile Arg 
        275                 280                 285             


Gln Thr Leu Ala Asn Leu Arg Leu Pro Ser Thr Ser Ala Asp Glu Pro 
    290                 295                 300                 


Arg Pro Leu Thr Asp Glu Glu His Ala Lys Ala Leu Ala Leu Leu Ser 
305                 310                 315                 320 


Thr Ala Arg Phe Val Glu Trp Pro Ala Leu Arg Arg Ala Leu Gly Leu 
                325                 330                 335     


Lys Arg Gly Val Lys Phe Thr Ala Glu Thr Glu Arg Asn Gly Ala Lys 
            340                 345                 350         


Gln Ala Ala Arg Gly Thr Ala Gly Asn Leu Thr Glu Ala Ile Leu Ala 
        355                 360                 365             


Pro Leu Ile Pro Gly Trp Ser Gly Trp Asp Leu Asp Arg Lys Asp Arg 
    370                 375                 380                 


Val Phe Ser Asp Leu Trp Ala Ala Arg Gln Asp Arg Ser Ala Leu Leu 
385                 390                 395                 400 


Ala Leu Ile Gly Asp Pro Arg Gly Pro Thr Arg Val Thr Glu Asp Glu 
                405                 410                 415     


Thr Ala Glu Ala Val Ala Asp Ala Ile Gln Ile Val Leu Pro Thr Gly 
            420                 425                 430         


Arg Ala Ser Leu Ser Ala Lys Ala Ala Arg Ala Ile Ala Gln Ala Met 
        435                 440                 445             


Ala Pro Gly Ile Gly Tyr Asp Glu Ala Val Thr Leu Ala Leu Gly Leu 
    450                 455                 460                 


His His Ser His Arg Pro Arg Gln Glu Arg Leu Ala Arg Leu Pro Tyr 
465                 470                 475                 480 


Tyr Ala Ala Ala Leu Pro Asp Val Gly Leu Asp Gly Asp Pro Val Gly 
                485                 490                 495     


Pro Pro Pro Ala Glu Asp Asp Gly Ala Ala Ala Glu Ala Tyr Tyr Gly 
            500                 505                 510         


Arg Ile Gly Asn Ile Ser Val His Ile Ala Leu Asn Glu Thr Arg Lys 
        515                 520                 525             


Ile Val Asn Ala Leu Leu His Arg His Gly Pro Ile Leu Arg Leu Val 
    530                 535                 540                 


Met Val Glu Thr Thr Arg Glu Leu Lys Ala Gly Ala Asp Glu Arg Lys 
545                 550                 555                 560 


Arg Met Ile Ala Glu Gln Ala Glu Arg Glu Arg Glu Asn Ala Glu Ile 
                565                 570                 575     


Asp Val Glu Leu Arg Lys Ser Asp Arg Trp Met Ala Asn Ala Arg Glu 
            580                 585                 590         


Arg Arg Gln Arg Val Arg Leu Ala Arg Arg Gln Asn Asn Leu Cys Pro 
        595                 600                 605             


Tyr Thr Ser Thr Pro Ile Gly His Ala Asp Leu Leu Gly Asp Ala Tyr 
    610                 615                 620                 


Asp Ile Asp His Val Ile Pro Leu Ala Arg Gly Gly Arg Asp Ser Leu 
625                 630                 635                 640 


Asp Asn Met Val Leu Cys Gln Ser Asp Ala Asn Lys Thr Lys Gly Asp 
                645                 650                 655     


Lys Thr Pro Trp Glu Ala Phe His Asp Lys Pro Gly Trp Ile Ala Gln 
            660                 665                 670         


Arg Asp Asp Phe Leu Ala Arg Leu Asp Pro Gln Thr Ala Lys Ala Leu 
        675                 680                 685             


Ala Trp Arg Phe Ala Asp Asp Ala Gly Glu Arg Val Ala Arg Lys Ser 
    690                 695                 700                 


Ala Glu Asp Glu Asp Gln Gly Phe Leu Pro Arg Gln Leu Thr Asp Thr 
705                 710                 715                 720 


Gly Tyr Ile Ala Arg Val Ala Leu Arg Tyr Leu Ser Leu Val Thr Asn 
                725                 730                 735     


Glu Pro Asn Ala Val Val Ala Thr Asn Gly Arg Leu Thr Gly Leu Leu 
            740                 745                 750         


Arg Leu Ala Trp Asp Ile Thr Pro Gly Pro Ala Pro Arg Asp Leu Leu 
        755                 760                 765             


Pro Thr Pro Arg Asp Ala Leu Arg Asp Asp Thr Ala Ala Arg Arg Phe 
    770                 775                 780                 


Leu Asp Gly Leu Thr Pro Pro Pro Leu Ala Lys Ala Val Glu Gly Ala 
785                 790                 795                 800 


Val Gln Ala Arg Leu Ala Ala Leu Gly Arg Ser Arg Val Ala Asp Ala 
                805                 810                 815     


Gly Leu Ala Asp Ala Leu Gly Leu Thr Leu Ala Ser Leu Gly Gly Gly 
            820                 825                 830         


Gly Lys Asn Arg Ala Asp His Arg His His Phe Ile Asp Ala Ala Met 
        835                 840                 845             


Ile Ala Val Thr Thr Arg Gly Leu Ile Asn Gln Ile Asn Gln Ala Ser 
    850                 855                 860                 


Gly Ala Gly Arg Ile Leu Asp Leu Arg Lys Trp Pro Arg Thr Asn Phe 
865                 870                 875                 880 


Glu Pro Pro Tyr Pro Thr Phe Arg Ala Glu Val Met Lys Gln Trp Asp 
                885                 890                 895     


His Ile His Pro Ser Ile Arg Pro Ala His Arg Asp Gly Gly Ser Leu 
            900                 905                 910         


His Ala Ala Thr Val Phe Gly Val Arg Asn Arg Pro Asp Ala Arg Val 
        915                 920                 925             


Leu Val Gln Arg Lys Pro Val Glu Lys Leu Phe Leu Asp Ala Asn Ala 
    930                 935                 940                 


Lys Pro Leu Pro Ala Asp Lys Ile Ala Glu Ile Ile Asp Gly Phe Ala 
945                 950                 955                 960 


Ser Pro Arg Met Ala Lys Arg Phe Lys Ala Leu Leu Ala Arg Tyr Gln 
                965                 970                 975     


Ala Ala His Pro Glu Val Pro Pro Ala Leu Ala Ala Leu Ala Val Ala 
            980                 985                 990         


Arg Asp Pro Ala Phe Gly Pro Arg  Gly Met Thr Ala Asn  Thr Val Ile 
        995                 1000                 1005             


Ala Gly  Arg Ser Asp Gly Asp  Gly Glu Asp Ala Gly  Leu Ile Thr 
    1010                 1015                 1020             


Pro Phe  Arg Ala Asn Pro Lys  Ala Ala Val Arg Thr  Met Gly Asn 
    1025                 1030                 1035             


Ala Val  Tyr Glu Val Trp Glu  Ile Gln Val Lys Gly  Arg Pro Arg 
    1040                 1045                 1050             


Trp Thr  His Arg Val Leu Thr  Arg Phe Asp Arg Thr  Gln Pro Ala 
    1055                 1060                 1065             


Pro Pro  Pro Pro Pro Glu Asn  Ala Arg Leu Val Met  Arg Leu Arg 
    1070                 1075                 1080             


Arg Gly  Asp Leu Val Tyr Trp  Pro Leu Glu Ser Gly  Asp Arg Leu 
    1085                 1090                 1095             


Phe Leu  Val Lys Lys Met Ala  Val Asp Gly Arg Leu  Ala Leu Trp 
    1100                 1105                 1110             


Pro Ala  Arg Leu Ala Thr Gly  Lys Ala Thr Ala Leu  Tyr Ala Gln 
    1115                 1120                 1125             


Leu Ser  Cys Pro Asn Ile Asn  Leu Asn Gly Asp Gln  Gly Tyr Cys 
    1130                 1135                 1140             


Val Gln  Ser Ala Glu Gly Ile  Arg Lys Glu Lys Ile  Arg Thr Thr 
    1145                 1150                 1155             


Ser Cys  Thr Ala Leu Gly Arg  Leu Arg Leu Ser Lys  Lys Ala Thr 
    1160                 1165                 1170             


<210>  55
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae 2603V/R

<400>  55

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  56
<211>  1370
<212>  PRT
<213>  Streptococcus agalactiae A909

<400>  56

Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210>  57
<211>  1259
<212>  PRT
<213>  Streptobacillus moniliformis

<400>  57

Met Lys Tyr Ile Leu Gly Leu Asp Leu Gly Val Ala Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Thr Glu Ile Asn Glu Lys Gly Glu Pro Val Gly Leu Ile Asp 
            20                  25                  30          


Ala Asn Ser Val Ile Phe Lys Pro Leu Asp Asn Asp Lys Gly Lys Leu 
        35                  40                  45              


Tyr Asn Val Glu Arg Arg Asp Lys Arg Gly Ser Arg Arg Ile Leu Arg 
    50                  55                  60                  


Arg Lys Lys His Arg Val Glu Arg Thr Lys Met Leu Leu Val Asn Ser 
65                  70                  75                  80  


Ser Phe Leu Thr Asn Glu Glu Ile Asp Asn Leu Tyr Val Gly Lys Leu 
                85                  90                  95      


Asp Asn Ile Tyr Glu Val Arg Leu Lys Gly Leu Lys Glu Gln Leu Ser 
            100                 105                 110         


Lys Asn Glu Ile Ala Arg Leu Met Ile Tyr Tyr Cys Lys Asn Arg Gly 
        115                 120                 125             


Phe Lys Ser Asn Arg Lys Thr Glu Asp Leu Glu Ile Leu Lys Ser Leu 
    130                 135                 140                 


Gly Glu Lys Ile Ser Glu Lys Asp Ser Asp Glu Lys Lys Leu Lys Pro 
145                 150                 155                 160 


Ile Ile Ala Lys Asn Thr Glu Leu Ile Glu Ser Lys Gly Leu Thr Pro 
                165                 170                 175     


Ile Glu Val Ile Tyr Met Ile Arg Glu Asn Asp Asn Ser Ile Leu Gly 
            180                 185                 190         


Phe Lys Asn Lys Glu Gly Asn Tyr Lys Phe Gly Phe Lys Arg Asn Gln 
        195                 200                 205             


Val Ile Asp Glu Val Arg Lys Ile Leu Gly Thr Gln Gln Ile Leu Ser 
    210                 215                 220                 


Lys Glu Ile Val Asp Glu Tyr Ile Asp Ile Leu Ser Ser Gln Arg Asp 
225                 230                 235                 240 


Phe Ser Asp Gly Pro Gly Gly Asp Ser Lys Tyr Lys Ile Asp Tyr Thr 
                245                 250                 255     


Lys Leu Ala Gly Lys Cys Lys Tyr Thr Gly Glu Val Arg Ala Val Lys 
            260                 265                 270         


Ser Ala Pro Ser Tyr Glu Ile Phe Thr Met Leu Gln Lys Leu Asn Asp 
        275                 280                 285             


Ile Arg Tyr Val Lys Phe Thr Ser Glu Asp Lys Ile Glu Lys Lys Lys 
    290                 295                 300                 


Leu Ser Lys Glu Val Ile His Lys Leu Tyr Asp Leu Val Val Glu Lys 
305                 310                 315                 320 


Asn Lys Thr Leu Thr Tyr Asp Leu Ile Glu Lys Ser Ile Asp Glu Glu 
                325                 330                 335     


Asn Ile Lys Leu Leu Asn Ile Pro Lys Leu Ser Lys Ser Lys Tyr Val 
            340                 345                 350         


Glu Leu Arg Lys Ser Tyr Phe Lys Glu Arg Asn Asp Asn Glu Asn Leu 
        355                 360                 365             


Thr Glu Glu Glu Ile Asn Ala Phe Asn Glu Lys Leu Asn Asn Glu Arg 
    370                 375                 380                 


Met Lys Gln Glu Leu Ile Arg Asn Asn Leu Lys Ala Tyr Lys Glu Leu 
385                 390                 395                 400 


Lys Ser Lys Phe Lys Lys Asn Asn Ile Asp Glu Asn Arg Ile Lys Glu 
                405                 410                 415     


Leu Gly Gly Ile Tyr Phe Leu Asp Leu Val Ala Glu Leu Leu Thr Tyr 
            420                 425                 430         


Ser Lys Thr Asp Glu Lys Leu Glu Tyr Phe Val Glu Asn Val Glu Arg 
        435                 440                 445             


Tyr Ser Leu Phe Lys Glu Gln Arg Asp Ile Val Glu Ile Ile Lys Thr 
    450                 455                 460                 


Phe Pro Asn Tyr Thr Lys Asn Gly Asn Leu Ser Leu Ser Leu Val Arg 
465                 470                 475                 480 


Glu Leu Asn Lys Leu Leu Met Glu Gly His Asp Tyr Glu Ser Ser Leu 
                485                 490                 495     


Ser Ser Leu Asn Tyr Tyr Ile Asp Thr Asp Val Asp Trp Glu Lys Phe 
            500                 505                 510         


Pro Thr Ile Ser Glu Ile Glu Asp Ser Leu Ser Thr Lys Ile Thr Asn 
        515                 520                 525             


Pro Asn Val Lys His Ile Leu Val Ile Leu Arg Lys Leu Tyr Asn Thr 
    530                 535                 540                 


Leu Leu Phe Lys Tyr Gly Arg Pro Glu Lys Val His Leu Glu Leu Ser 
545                 550                 555                 560 


Arg Asp Phe Ser Asn Asp Phe Ser Thr Arg Asn Lys Ile Gln Lys Glu 
                565                 570                 575     


Gln Leu Glu Asn Lys Val Arg Arg Glu Val Ala Ala Phe Glu Met Tyr 
            580                 585                 590         


Gly Ala Asn Lys Asp Ile Val Ala Gly Lys Asp Arg Leu Ser Asn Asp 
        595                 600                 605             


Asp Phe Val Arg Ile Lys Leu Trp Glu Glu Gln Asn Lys Val Cys Met 
    610                 615                 620                 


Tyr Ser Gly Arg Thr Ile Glu Lys Tyr Gln Leu Thr Ser Ala Glu Val 
625                 630                 635                 640 


Gln Ile Asp His Ile Leu Pro Tyr Ser Lys Ser Phe Asp Asn Ser Tyr 
                645                 650                 655     


Ser Asn Lys Val Leu Val Phe Ser Asn Glu Asn Gln Asp Lys Lys Glu 
            660                 665                 670         


Arg Thr Pro Tyr Gln Trp Leu Lys Gly Thr Glu Lys Trp Asn Glu Phe 
        675                 680                 685             


Lys Gln Arg Val Arg Leu Asn Leu Asn Ile Ser Asn Lys Lys Lys Glu 
    690                 695                 700                 


Asn Leu Leu Phe Glu Asp Glu Val Val Asn Asn Glu Phe Leu Glu Arg 
705                 710                 715                 720 


Glu Leu His Ala Thr Ser Tyr Ser Ser Arg Leu Ala Leu Asn Ile Phe 
                725                 730                 735     


Gln Arg Leu Ile Pro Val Ser Asp Glu Asp Lys Tyr Asp Glu His Gly 
            740                 745                 750         


Asn Glu Lys Val Lys Tyr Leu Tyr Asn Arg Asn Val Ile Ala Phe Gln 
        755                 760                 765             


Gly Lys Met Thr Ser Met Leu Arg Asn Leu Tyr Ser Leu Asn Lys Tyr 
    770                 775                 780                 


Thr His Ser Phe Glu Ser Asp Thr Leu Asp Ile Asp Asn Lys Ala Phe 
785                 790                 795                 800 


Ile Leu Lys Glu Phe Glu Ile Asn Lys Asp Asn Leu Lys Met Thr Ala 
                805                 810                 815     


Tyr Asn Val Asn Thr Gly Leu Glu Ile Thr Ser Glu Thr Lys Val Glu 
            820                 825                 830         


Lys Asn Lys Ser Gly Glu Phe Lys Thr Ile Lys Asp Glu Leu Leu Lys 
        835                 840                 845             


Lys Glu Leu Asp Lys Lys Glu Asn Leu Ile Glu Ile Ser Asp Tyr Phe 
    850                 855                 860                 


Lys Asp Lys Val Leu Phe Asp Leu Lys Ile Val Asp Phe Glu Glu Ile 
865                 870                 875                 880 


Asp Thr Val Glu Pro Glu Ile Ile Ser Ile Leu Tyr Lys Met Ile Thr 
                885                 890                 895     


Ala Leu Lys Glu Glu Val Tyr Ser Lys Asn Arg Glu Asn His Leu His 
            900                 905                 910         


His Ser Leu Asp Ala Phe Leu Leu Thr Ile Met Asn Arg Ser Met Gln 
        915                 920                 925             


Met Lys Leu Ile Lys Tyr Asn Gln Leu Ile Ser Val Leu Lys Asn Lys 
    930                 935                 940                 


Glu Ile Glu Ile Phe Asn Glu Glu Lys Gly Glu Tyr Ile Asp Ser Lys 
945                 950                 955                 960 


Glu Phe Ala Glu Glu Leu Gln Lys Gln Lys Ile Ile Asp Ile Asp Gly 
                965                 970                 975     


Asn Glu Arg Gly Ile Lys Phe Asn Val Asn Gly Lys Thr His Arg Leu 
            980                 985                 990         


Asn Leu Val Lys Pro Tyr Glu Asn  Phe Leu Asp Asp Ile  Lys Asn Lys 
        995                 1000                 1005             


Ile Phe  Asp Lys Arg Glu Asn  Asn Lys Leu Pro Tyr  His Val Val 
    1010                 1015                 1020             


Lys Ser  Lys Val Ser Gly Ala  Leu His Ala Glu Thr  Ile Leu Gly 
    1025                 1030                 1035             


Glu Ser  Lys Gly Glu Ile Thr  Lys Arg Ile Ser Val  Phe Asp Ile 
    1040                 1045                 1050             


Asn Tyr  Lys Asn Leu Gly Lys  Ile Phe Asp Lys Asp  Gly Ser Gln 
    1055                 1060                 1065             


Lys Glu  Ile Tyr Glu Thr Leu  Val Lys Trp Leu Glu  Ala Lys Ser 
    1070                 1075                 1080             


Lys Asp  Tyr Pro Lys Leu Lys  Asn Gly Asn Ile Ile  Lys Lys Val 
    1085                 1090                 1095             


Lys Ile  Val Asp Gly Asn Lys  Asp Lys Leu Ile Lys  Leu Gly Asn 
    1100                 1105                 1110             


Lys Arg  Tyr Val Glu Met Gly  Arg Thr Thr Val Lys  Ile Leu Val 
    1115                 1120                 1125             


Leu Lys  Lys Glu Ala Glu Glu  Gly Leu Lys Phe Ala  Ser Ile Gly 
    1130                 1135                 1140             


Arg Tyr  Lys Tyr Asn Leu Leu  Lys Ser Glu Lys Asp  Val Asn Ile 
    1145                 1150                 1155             


Ser Ile  Trp Lys Asp Ala Ile  His Phe Cys Lys Val  Arg Tyr Asn 
    1160                 1165                 1170             


Lys Leu  Lys Glu Asn Gly Tyr  Arg Leu Ile His Glu  Leu Ile Pro 
    1175                 1180                 1185             


Gly Glu  Thr Ile Glu Leu Glu  Leu Asn Lys Gly Asn  Ile Ser Lys 
    1190                 1195                 1200             


Cys Leu  Val Val Gly Phe Ser  Gly Gly Lys Ile Glu  Ile Ser Ser 
    1205                 1210                 1215             


Val Ile  Gly Asp Ala Leu Asp  Leu Ile Asn Asp Lys  Ile Ser Thr 
    1220                 1225                 1230             


Arg Ile  Lys Glu Arg Tyr Tyr  Ile Thr Val Ser Thr  Ile Lys Ser 
    1235                 1240                 1245             


Ile Lys  Lys Ile Asn Lys Asn  Ile Leu Gly Asp 
    1250                 1255                 


<210>  58
<211>  1344
<212>  PRT
<213>  Streptococcus mutans

<400>  58

Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp Leu 
    450                 455                 460                 


Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu Ile 
465                 470                 475                 480 


Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr Asn 
                485                 490                 495     


Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys Gln 
    530                 535                 540                 


Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys Asp 
545                 550                 555                 560 


Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile Val 
                565                 570                 575     


Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser Tyr 
            580                 585                 590         


Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr Ser 
625                 630                 635                 640 


Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg Asn 
            660                 665                 670         


Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Asn 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe 
    690                 695                 700                 


Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn Leu 
705                 710                 715                 720 


Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Phe 
        755                 760                 765             


Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu Thr 
    770                 775                 780                 


Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys Ser 
865                 870                 875                 880 


Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp Glu 
    930                 935                 940                 


Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 
            980                 985                 990         


Gly Lys Ala Leu Leu Gly Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Pro His Phe  His Gly His Lys Glu  Asn Lys Ala 
    1010                 1015                 1020             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1025                 1030                 1035             


Lys Asp  Asp Val Arg Thr Asp  Lys Asn Gly Glu Ile  Ile Trp Lys 
    1040                 1045                 1050             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Lys Val Leu  Ser Tyr Pro 
    1055                 1060                 1065             


Gln Val  Asn Ile Val Lys Lys  Val Glu Glu Gln Thr  Gly Gly Phe 
    1070                 1075                 1080             


Ser Lys  Glu Ser Ile Leu Pro  Lys Gly Asn Ser Asp  Lys Leu Ile 
    1085                 1090                 1095             


Pro Arg  Lys Thr Lys Lys Phe  Tyr Trp Asp Thr Lys  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser Ile Leu  Val Ile Ala 
    1115                 1120                 1125             


Asp Ile  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Thr  Val Lys Ala 
    1130                 1135                 1140             


Leu Val  Gly Val Thr Ile Met  Glu Lys Met Thr Phe  Glu Arg Asp 
    1145                 1150                 1155             


Pro Val  Ala Phe Leu Glu Arg  Lys Gly Tyr Arg Asn  Val Gln Glu 
    1160                 1165                 1170             


Glu Asn  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Lys Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Leu Leu  Ala Ser Ala Arg Glu  Leu Gln Lys 
    1190                 1195                 1200             


Gly Asn  Glu Ile Val Leu Pro  Asn His Leu Gly Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Asn Ile His Lys  Val Asp Glu Pro Lys  His Leu Asp 
    1220                 1225                 1230             


Tyr Val  Asp Lys His Lys Asp  Glu Phe Lys Glu Leu  Leu Asp Val 
    1235                 1240                 1245             


Val Ser  Asn Phe Ser Lys Lys  Tyr Thr Leu Ala Glu  Gly Asn Leu 
    1250                 1255                 1260             


Glu Lys  Ile Lys Glu Leu Tyr  Ala Gln Asn Asn Gly  Glu Asp Leu 
    1265                 1270                 1275             


Lys Glu  Leu Ala Ser Ser Phe  Ile Asn Leu Leu Thr  Phe Thr Ala 
    1280                 1285                 1290             


Ile Gly  Ala Pro Ala Thr Phe  Lys Phe Phe Asp Lys  Asn Ile Asp 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Thr  Thr Glu Ile Leu Asn  Ala Thr Leu 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1325                 1330                 1335             


Asn Lys  Leu Gly Gly Asp 
    1340                 


<210>  59
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes SSI1

<400>  59

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  60
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes NZ131

<400>  60

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Ile Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Leu Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Thr Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Ile Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Val Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Val Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Cys Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  61
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes M1GAS

<400>  61

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  62
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes MGAS5005

<400>  62

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  63
<211>  1121
<212>  PRT
<213>  Streptococcus thermophilus LMD9

<400>  63

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210>  64
<211>  1388
<212>  PRT
<213>  Streptococcus thermophilus LMD9

<400>  64

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Thr Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210>  65
<211>  1128
<212>  PRT
<213>  Streptococcus thermophilus Z1066

<400>  65

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Arg Leu Arg Leu Gln Ile Lys 
    450                 455                 460                 


Gln Asn Ile Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Leu Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Val Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Thr Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Ala His Lys Ile Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Glu Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr 
    850                 855                 860                 


Asp Ala Phe Met Lys Ile Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met 
865                 870                 875                 880 


Tyr Arg His Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Pro Ile Leu 
                885                 890                 895     


Glu Asn Tyr Pro Asn Lys Gln Met Asn Glu Lys Gly Lys Glu Val Pro 
            900                 905                 910         


Cys Asn Pro Phe Leu Lys Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys 
        915                 920                 925             


Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr 
    930                 935                 940                 


Asp Ser Lys Leu Leu Gly Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser 
945                 950                 955                 960 


Lys Asn Lys Val Val Leu Gln Ser Leu Lys Pro Trp Arg Thr Asp Val 
                965                 970                 975     


Tyr Phe Asn Lys Ala Thr Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr 
            980                 985                 990         


Ala Asp Leu Gln Phe Glu Lys Gly  Thr Gly Thr Tyr Lys  Ile Ser Gln 
        995                 1000                 1005             


Glu Lys  Tyr Asn Asp Ile Lys  Lys Lys Glu Gly Val  Asp Ser Asp 
    1010                 1015                 1020             


Ser Glu  Phe Lys Phe Thr Leu  Tyr Lys Asn Asp Leu  Leu Leu Val 
    1025                 1030                 1035             


Lys Asp  Thr Glu Thr Lys Glu  Gln Gln Leu Phe Arg  Phe Leu Ser 
    1040                 1045                 1050             


Arg Thr  Leu Pro Lys Gln Lys  His Tyr Val Glu Leu  Lys Pro Tyr 
    1055                 1060                 1065             


Asp Lys  Gln Lys Phe Glu Gly  Gly Glu Ala Leu Ile  Lys Val Leu 
    1070                 1075                 1080             


Gly Asn  Val Ala Asn Gly Gly  Gln Cys Ile Lys Gly  Leu Ala Lys 
    1085                 1090                 1095             


Ser Asn  Ile Ser Ile Tyr Lys  Val Arg Thr Asp Val  Leu Gly Asn 
    1100                 1105                 1110             


Gln His  Ile Ile Lys Asn Glu  Gly Asp Lys Pro Lys  Leu Asp Phe 
    1115                 1120                 1125             


<210>  66
<211>  1122
<212>  PRT
<213>  Streptococcus thermophilus 18311

<400>  66

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Ser Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Asn Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Val Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


His Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Glu Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Glu Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Leu Gly 
    930                 935                 940                 


Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser Lys Asn Lys Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Asn Thr 
                965                 970                 975     


Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu 
            980                 985                 990         


Lys Lys Thr Gly Thr Tyr Lys Ile  Ser Gln Glu Lys Tyr  Asn Gly Ile 
        995                 1000                 1005             


Met Lys  Glu Glu Gly Val Asp  Ser Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Leu  Leu Val Lys Asp Thr  Glu Thr Lys 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg Thr Met  Pro Asn Val 
    1040                 1045                 1050             


Lys Tyr  Tyr Val Glu Leu Lys  Pro Tyr Ser Lys Asp  Lys Phe Glu 
    1055                 1060                 1065             


Lys Asn  Glu Ser Leu Ile Glu  Ile Leu Gly Ser Ala  Asp Lys Ser 
    1070                 1075                 1080             


Gly Arg  Cys Ile Lys Gly Leu  Gly Lys Ser Asn Ile  Ser Ile Tyr 
    1085                 1090                 1095             


Lys Val  Arg Thr Asp Val Leu  Gly Asn Gln His Ile  Ile Lys Asn 
    1100                 1105                 1110             


Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120         


<210>  67
<211>  1395
<212>  PRT
<213>  Treponema denticola

<400>  67

Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Thr Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Ala Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Ile Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Phe Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Ala Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Asp Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Thr Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Ala Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Val  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Phe Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Asn Asp  Ser Phe Leu Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asn  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Ser Glu Ile Arg  Ser Gln Arg Glu Lys  Ile Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Trp Lys Lys Thr  Lys Asn Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Tyr Ser  Gly Val Ala Lys Ile  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210>  68
<211>  1032
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: TGRD_056 (Csn1-like 
       CRISPR-associated protein) of Uncultered bacterium TG1RsD17"

<400>  68

Met Leu Tyr His Ile Ala Asn His Arg Gly Thr Asp Ser Val Arg Ser 
1               5                   10                  15      


Phe Leu Glu Tyr Asp Asp Asp Lys Ile Lys Glu Asn Thr Leu Thr Ala 
            20                  25                  30          


Lys Ile Ala Lys Glu Thr Lys Lys Val Ile Asp Ala Lys Lys Tyr Arg 
        35                  40                  45              


Thr Phe Gly Glu Tyr Leu Tyr Lys Gly Lys Ile Glu Lys Phe Gln Gln 
    50                  55                  60                  


Asn Ile Arg Lys Lys Val Ser Asn Arg Lys Thr Pro Ala Asn Lys Asn 
65                  70                  75                  80  


Lys Glu Phe Ala Val Thr Arg Asp Val Ile Ile Lys Glu Thr Glu Lys 
                85                  90                  95      


Ile Leu Ala Ser Gln Lys Gln Tyr Tyr Thr Tyr Ile Leu Thr Asp Glu 
            100                 105                 110         


Tyr Ile Lys Lys Ile Lys Asp Ala Ile Ser Tyr Gln Thr Glu Lys Leu 
        115                 120                 125             


Ile Pro Glu Ser Gly Tyr Cys Pro Tyr Phe Lys Asp Glu Lys Arg Leu 
    130                 135                 140                 


Pro Arg Ser His Lys Leu Asn Glu Tyr Arg Arg Met Tyr Glu Ala Leu 
145                 150                 155                 160 


Asn Asn Ala Lys Tyr Phe Asp Pro Val Leu Asp Glu Asn Thr Gly Glu 
                165                 170                 175     


Ile Leu Ser Tyr Gln Glu Lys Glu Phe Ser Arg Glu Glu Lys Lys Ile 
            180                 185                 190         


Leu Phe Asp Glu Val Leu Leu Lys Gly Met Glu Leu Thr Glu Ser Gly 
        195                 200                 205             


Ala Lys Lys Leu Leu Tyr His Leu Pro Asp Gly Cys Glu Val Gln Leu 
    210                 215                 220                 


Gln Gly Arg Asp Lys Thr Thr Gln Lys Ile Lys Gly Tyr Ala Leu Val 
225                 230                 235                 240 


Asp Leu Glu Ala Ser Pro Phe Trp Leu Arg Leu Ser Gln Gln Gln Gln 
                245                 250                 255     


Asp Glu Phe Leu Tyr Asp Trp Asn Ser Leu Pro Leu Glu Lys Leu Lys 
            260                 265                 270         


Pro Lys Leu Thr Asn Tyr Tyr Ser Leu Thr Glu Ser Glu Val Asp Glu 
        275                 280                 285             


Thr Phe Gln Glu Ile Lys Leu Pro Ser Asn Tyr Ala Ser Val Gly Lys 
    290                 295                 300                 


Lys Ala Met Glu Ile Leu Leu Thr Tyr Ile Lys Asp Gly Cys Ser Tyr 
305                 310                 315                 320 


Thr Glu Ala Leu Glu Lys Ala Val Ser Glu Gly Lys Leu Lys Val Asp 
                325                 330                 335     


Lys Gln Thr Met Ile Tyr Asp Ser Leu Pro Tyr Tyr Gly Lys Ile Leu 
            340                 345                 350         


Lys Glu Ser Thr Gln Lys Leu Ile Gly Lys Ala Phe Ser Lys Gln Phe 
        355                 360                 365             


Ala Asp Arg Asn Tyr Lys Glu Pro Asp Thr Asn Lys Asn Glu Arg Glu 
    370                 375                 380                 


Phe Gly Lys Ile Ala Asn Pro Val Val His Gln Thr Leu Asn Glu Leu 
385                 390                 395                 400 


Arg Lys Leu Ile Asn Glu Ile Ile Thr Val Phe Gly Lys Lys Pro Leu 
                405                 410                 415     


Glu Ile Gly Leu Glu Thr Thr Arg Glu Leu Lys Lys Ser Lys Lys Asn 
            420                 425                 430         


Arg Glu Tyr Leu Ser Lys Gln Gln Asn Lys Asn Glu Tyr Ala Arg Asn 
        435                 440                 445             


Arg Ile Tyr Lys Glu Tyr Ile Glu Pro His Leu Ser Gln Ile Lys Ser 
    450                 455                 460                 


Arg Gln Glu Asn Pro Ser Lys Tyr Ile Ser Lys Phe Glu Leu Leu Glu 
465                 470                 475                 480 


Glu Gln Asn Phe Ile Cys Pro Phe Cys Ser Glu Lys Ile Thr Pro Asp 
                485                 490                 495     


Asp Ile Ile Asn Ser Lys Val Asp Val Glu His Ile Phe Pro Ile Glu 
            500                 505                 510         


Glu Ser Glu Asp Ile Thr Lys Asn Asn Leu Val Ile Ala His Asn Glu 
        515                 520                 525             


Cys Asn Ala Asp Lys Gly Lys Lys Ser Pro Phe Asp Ala Phe Gly Asp 
    530                 535                 540                 


Lys Thr Ser Gly Lys Tyr Arg Trp Asn Cys Ile Leu His Asn Ala Gln 
545                 550                 555                 560 


Lys Asn Leu Pro His Lys Val Trp Arg Phe Tyr Gln Gly Ser Leu Glu 
                565                 570                 575     


Lys Phe Leu Glu Asn Lys Pro Met Ser Arg Arg Phe Gly Thr Asp Asn 
            580                 585                 590         


Ser Tyr Ile Ser Lys Ile Ala Ala Arg Tyr Leu Ala Cys Leu Phe Asn 
        595                 600                 605             


Asp Pro Tyr His Ser Glu Ile Phe Cys Ile Lys Ser Ser Leu Ile Ala 
    610                 615                 620                 


Gln Leu Arg Ile Ala Trp Asp Leu Asn Ser Ile Met Val Pro Leu Val 
625                 630                 635                 640 


Lys Asn Ile Leu Ser Glu Lys Glu Leu Glu Glu Phe Lys Ile Ser Lys 
                645                 650                 655     


Asn Lys Lys Ile Arg Ile Asp Asn Arg His His Ala Leu Asp Ala Ile 
            660                 665                 670         


Val Ile Ala Tyr Ala Asn Arg Gly Tyr His Asn Phe Leu Asn Arg Ile 
        675                 680                 685             


His Ala Lys Glu Tyr Lys Ile Asn Tyr Arg Glu Lys Ser Trp Leu Ser 
    690                 695                 700                 


Lys Ile Leu Leu Pro Pro Leu Asn Arg Asp Leu Glu Asp Phe Lys Ile 
705                 710                 715                 720 


Ser Val Lys Asp Ser Ile Glu Lys Ala Asn Val Ser Ile Lys His Asp 
                725                 730                 735     


His Asn Thr Asn Gly Ser Leu Val Lys Ala Thr Ala Tyr Lys Val Tyr 
            740                 745                 750         


Tyr Ser Gly Ala Gly Glu Tyr Ile Ile Thr Thr Ser Lys Asn Val Glu 
        755                 760                 765             


Glu Ile Ser Phe Lys Glu Lys Glu Asp Pro Lys Asp Thr Leu Tyr Arg 
    770                 775                 780                 


Ala Leu Cys Lys Phe Glu Cys Arg Asp Ile Asp Ile Lys Asp Glu Lys 
785                 790                 795                 800 


Leu Ile Lys Lys Leu Lys Tyr Asn Ser Thr Leu Tyr Lys Lys Val Gln 
                805                 810                 815     


Asn Asn Leu Ser Lys Ala Lys Gln Glu Leu Glu Gln Asp Asn Lys Lys 
            820                 825                 830         


Thr Glu Glu Glu Gly Lys Lys Ser Gln Lys Ile Thr Glu Val Arg Ile 
        835                 840                 845             


Tyr Lys Lys Ala Cys Ser Leu Val Lys Gly Gln Tyr Ile Gln Cys Gly 
    850                 855                 860                 


Ser Arg Leu Lys Asp Lys Phe Phe Ala Val Lys Glu Pro Thr Glu Ile 
865                 870                 875                 880 


Lys Thr Gly Leu Gly Tyr Asp Thr Gly Asp Asn Leu Phe Leu Asp Leu 
                885                 890                 895     


Tyr Tyr Asp Lys Thr Gly Lys Leu Cys Gly Glu Ile Ile Arg Lys Val 
            900                 905                 910         


Asn Phe Asn Arg Asn Lys Pro Asn Tyr Gln Lys Glu Gly Tyr Thr Leu 
        915                 920                 925             


Phe Glu Arg Ile Tyr Gln Ser Asp Ile Leu Glu Val Asp Thr Ser Glu 
    930                 935                 940                 


Asp Arg Ile Ser Leu Lys Asn Lys Thr Gly Ser Ala Pro Ser Asp Arg 
945                 950                 955                 960 


Thr Phe Ile Lys Val Asn Thr Phe Thr Glu Val Asn Ala Tyr Phe Asp 
                965                 970                 975     


Gly Lys Arg Asp Lys Ile Gln Ile Phe Phe Gly Asn Leu Leu Lys Ser 
            980                 985                 990         


Ser Phe Lys Asn Asp Ser Phe Phe  Ile Ser Ser Met Gln  Lys Tyr Asn 
        995                 1000                 1005             


Val Arg  Lys Val Ile Leu Thr  Ser Leu Gly Ile Ile  Lys Tyr Arg 
    1010                 1015                 1020             


Ser Gln  Ile Leu Lys Asn Lys  Glu Val 
    1025                 1030         


<210>  69
<211>  1032
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: TGRD_222 
       (CRISPR-associated protein Csn1) of Uncultered bacterium 
       TG1RsD17"

<400>  69

Met Lys Lys Arg Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Trp Ala Leu Val Glu Phe Asp Asp Glu Phe Gln Asp Asn Lys Lys Lys 
            20                  25                  30          


Gly Thr Ile Ile Lys Ser Gly Val Arg Ile Phe Thr Arg Ala Glu Thr 
        35                  40                  45              


Pro Lys Glu Arg Glu Ser Leu Ala Lys Pro Arg Arg Glu Ala Arg Ser 
    50                  55                  60                  


Gln Arg Arg Arg Ile Arg Arg Arg Val Glu Arg Leu Asn Ser Ile Arg 
65                  70                  75                  80  


Glu Leu Phe Val Lys Asn Gly Val Val Glu Glu Trp Ser Val Ser Lys 
                85                  90                  95      


Lys Asn Pro Asn Asn Ile Tyr Ile Thr Leu Asn Gln Ile Lys Thr Pro 
            100                 105                 110         


Trp Gln Leu Arg Met Glu Ser Leu Asp Arg Lys Leu Thr Asn Glu Gln 
        115                 120                 125             


Phe Ala Val Val Leu Thr His Leu Ala Lys His Arg Gly Tyr Lys Ser 
    130                 135                 140                 


Leu Arg Lys Asp Asp Lys Ala Gly Lys Val Leu Glu Ala Ile Ser Gln 
145                 150                 155                 160 


Asn Lys Lys Arg Leu Asn Asp Ser Asp Tyr Arg Thr Leu Gly Glu Met 
                165                 170                 175     


Phe Cys Lys Asn Glu Ser Tyr Lys Glu His Lys Arg Asn Lys Gly Gly 
            180                 185                 190         


Glu Tyr Ile Asn Ser Val Ala Arg Glu Leu Ile Glu Glu Glu Val Glu 
        195                 200                 205             


Lys Ile Phe Val Lys Gln Arg Glu Lys Gly Asn Asn Phe Ala Asp Val 
    210                 215                 220                 


Asn Thr Glu Arg Glu Tyr Leu Lys Ile Ala Phe Ser Gln Lys Pro Ala 
225                 230                 235                 240 


Gly Ser Ile Ser Lys Met Val Gly Phe Cys Thr Phe Glu Asn Gly Glu 
                245                 250                 255     


Lys Arg Ala Pro Arg Asp Ser Tyr Ser Ala Glu Leu Phe Lys Val Leu 
            260                 265                 270         


Cys Thr Ile Asn Asn Thr Thr Phe Thr Asp Met Lys Thr Gly Glu Ile 
        275                 280                 285             


Arg Ser Phe Ser Lys Glu Glu Ile Gly Lys Thr Leu Glu Thr Val Lys 
    290                 295                 300                 


Asn Val Lys Asp Val Lys Tyr Ala Lys Ile Arg Lys Asp Leu Gly Leu 
305                 310                 315                 320 


Glu Asp Ser Val Lys Phe Ser Gly Val Asp Tyr Arg Glu Asn Ala Lys 
                325                 330                 335     


Ser Lys Gly Glu Gly Glu Ile Phe Val Ser Met Lys Thr Tyr His Glu 
            340                 345                 350         


Ile Lys Ser Lys Ile Glu Lys Leu Ser Lys Glu Lys Trp Asp Asn Leu 
        355                 360                 365             


Lys Gly Asn Thr Glu Leu Leu Asp Ser Ile Val Asn Ile Ile Ala Asn 
    370                 375                 380                 


Leu Lys Asp Asp Glu Ser Ile Lys Lys Glu Phe Gln Lys Leu Lys Ile 
385                 390                 395                 400 


Asp Glu Asp Ile Ile Asp Val Leu Leu Asn Phe Glu Phe Lys Lys Phe 
                405                 410                 415     


Ile Asn Leu Ser Phe Lys Ala Leu Arg Lys Ile Ile Pro Phe Gln Phe 
            420                 425                 430         


Gln Gly Gln Lys Tyr Ile Thr Ala Ser Thr Ser Ala Gly Tyr Ser Leu 
        435                 440                 445             


Lys Gln Glu Gly Ile Lys Asn Lys Leu Val Pro Pro Ala Lys Glu Asn 
    450                 455                 460                 


Ile Asn Val Ala Val Val Ala Arg Ala Phe Ala Gln Thr Arg Lys Val 
465                 470                 475                 480 


Ile Asn Ala Val Ile Arg Lys Tyr Gly Gln Phe Asp Gln Ile Asn Ile 
                485                 490                 495     


Glu Leu Ala Thr Glu Leu Lys Asn Ser Lys Phe Asp Arg Ser Lys Ile 
            500                 505                 510         


Glu Glu Gly Gln Lys Lys Phe Gln Ser Gln Lys Asp Lys Ile Phe Lys 
        515                 520                 525             


Glu Val Gln Glu Leu Arg Gly Gly Met Thr Pro Ser Ser Ser Leu Leu 
    530                 535                 540                 


Leu Lys Tyr Arg Leu Trp Arg Glu Gln Asp Glu Arg Cys Val Tyr Ser 
545                 550                 555                 560 


Gly Arg Lys Ile Ser Phe Glu Asp Leu Leu Asp Thr Gly Phe Leu Asp 
                565                 570                 575     


Ile Asp His Ile Ile Pro Tyr Ser Lys Ser Met Asp Asp Ser Phe Asn 
            580                 585                 590         


Asn Lys Val Leu Cys Leu Ala Glu Glu Asn Arg Asn Lys Lys Asn Asp 
        595                 600                 605             


Ile Pro Phe Asn Tyr Tyr Gln Arg Ile Asp Arg Asp Trp Asn Leu Leu 
    610                 615                 620                 


Ile Ser Ile Ile Thr Ser Met Lys Asn Met Lys Ile Ala Lys Lys Ser 
625                 630                 635                 640 


Arg Leu Leu Lys Gln Glu Leu Ser Asp Ile Glu Gly Phe Ile Glu Arg 
                645                 650                 655     


Asn Ile Asn Asp Thr Arg Tyr Ala Thr Arg Tyr Ile Lys Asp Phe Leu 
            660                 665                 670         


Glu Asn Asn Leu Glu Phe Lys Glu Asn Glu Phe Ile Lys Val Lys Val 
        675                 680                 685             


Gln Ala Arg Ser Gly Gly Leu Thr Ser Val Leu Ser Tyr Asn Trp Gly 
    690                 695                 700                 


Met Ser Lys Asp Arg Glu Glu Ser Tyr Phe His His Ala Lys Asp Ala 
705                 710                 715                 720 


Ile Ile Val Ala Cys Ser Thr Gln Gly Met Val Gln Tyr Ile Ser Lys 
                725                 730                 735     


Ile Ser Gln Gln Tyr Glu Asn Asp Lys Asp Lys Met Lys Lys Ile Lys 
            740                 745                 750         


Asp Lys Thr Glu Asn Cys Ile Pro Lys Pro Trp Asp Ser Phe Arg Ala 
        755                 760                 765             


Asp Val Glu Glu Ser Ile Glu Gly Ile Phe Val Ser Phe Ala Pro Arg 
    770                 775                 780                 


His Lys Val Thr Gly Ser Ala His Lys Glu Thr Ile Tyr Ser Lys Lys 
785                 790                 795                 800 


His Leu Glu Lys Glu Arg Tyr Val Thr Val Lys Lys Ser Leu Asp Lys 
                805                 810                 815     


Ile Lys Leu Ser Asp Leu Glu Asn Ile Pro Cys Asn Glu Asn Cys Gly 
            820                 825                 830         


Ile Ile Arg Val Leu Lys Glu Arg Leu Glu Lys Phe Lys Asn Asp Ser 
        835                 840                 845             


Leu Lys Ala Phe Ala Asp Pro Val His Met Pro Thr Lys Cys Pro Asn 
    850                 855                 860                 


Lys Lys Gly Pro Val Ile Arg Ser Val Lys Ile Lys Glu Ser Asn Lys 
865                 870                 875                 880 


Thr Gly Ile Glu Val Arg Lys Gly Leu Ala Glu Arg Gly Glu Met Val 
                885                 890                 895     


Arg Val Asp Val Phe Ile Lys Asp Lys Lys Tyr Tyr Leu Val Pro Ile 
            900                 905                 910         


Tyr Val Ser Asp Phe Lys Asn Lys Asp Leu Pro Asn Lys Ala Ile Ala 
        915                 920                 925             


Ala Leu Lys Leu Glu Asn Glu Trp Ile Met Ile Asp Lys Thr Tyr Ser 
    930                 935                 940                 


Phe Lys Phe Ser Leu Phe Lys Asp Asp Leu Ile Lys Ile Lys Lys Lys 
945                 950                 955                 960 


Lys Glu Glu Ile Phe Gly Tyr Phe Gly Gly Val His Arg Ser Thr Gly 
                965                 970                 975     


Thr Ile Lys Ile Lys Ser Arg His Lys Pro Lys Glu Ile Asp Glu Gly 
            980                 985                 990         


Ile Gly Ser Arg Cys Leu Leu Asp  Phe Arg Lys Phe Gln  Val Asp Val 
        995                 1000                 1005             


Leu Gly  Asn Tyr Thr Glu Val  Lys His Glu Lys Arg  Met Pro Ala 
    1010                 1015                 1020             


Tyr Ile  Thr Arg Lys Asp Lys  Lys His 
    1025                 1030         


<210>  70
<211>  1067
<212>  PRT
<213>  Verminephrobacter eiseniae

<400>  70

Met Asn Lys Ala Val Ala Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr 
1               5                   10                  15      


Ser Leu Gly Trp Ala Ile Phe Arg Leu Asn Glu Ala Arg Glu Pro Thr 
            20                  25                  30          


Ala Ile Ile Arg Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Ala 
        35                  40                  45              


Asn Ser Glu Pro Leu Ala Val His Arg Arg Val Ala Arg Ala Met Arg 
    50                  55                  60                  


Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Lys Arg Met His Asp Gln 
65                  70                  75                  80  


Leu Val Gln His Gly Phe Phe Pro Ala Glu Val Ala Glu Arg Lys Glu 
                85                  90                  95      


Leu Glu Arg Leu Asn Pro Tyr Gln Leu Arg Ala Lys Gly Leu His Glu 
            100                 105                 110         


Ala Leu Thr Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gln 
        115                 120                 125             


Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Lys Asp Asn Asp 
    130                 135                 140                 


Ser Gly Ala Leu Lys Gln Ala Ile Ser Glu Leu Arg Lys Arg Ile Gln 
145                 150                 155                 160 


Asp Ser Asp Cys Ala Thr Ala Gly Glu Trp Phe Trp Lys Glu Arg Met 
                165                 170                 175     


Gln Gln Lys Pro Glu Gly Val Arg Gly Gln Trp Val Arg Ala Arg Tyr 
            180                 185                 190         


Arg Lys Thr Pro Ser Thr Thr Asp Glu Gly Lys Lys Arg Ile Gly Tyr 
        195                 200                 205             


Asp Leu Tyr Val Asp Arg Ala Met Val Glu Gln Glu Phe Asp Ala Leu 
    210                 215                 220                 


Trp Ala Ala Gln Ala Ala Leu Gln Pro Gly Leu Phe Thr Glu Ala Ala 
225                 230                 235                 240 


Arg Ala Glu Leu Lys Asp Thr Leu Leu Tyr Gln Arg Asp Leu Arg Pro 
                245                 250                 255     


Val Lys Pro Gly Arg Cys Thr Leu Leu Pro Ala Glu Glu Arg Ala Pro 
            260                 265                 270         


Leu Ala Leu Pro Ser Thr Gln Arg Phe Arg Ile Leu Gln Glu Val Asn 
        275                 280                 285             


Asn Leu Arg Leu Leu Asp Glu Ala Leu Arg Glu Val Pro Leu Asn Leu 
    290                 295                 300                 


Ala Gln Arg Asp Ala Val Val Ser Ala Leu Glu Gly Lys Lys Glu Leu 
305                 310                 315                 320 


Ser Phe Ala Ala Ile Arg Lys Leu Leu Thr Leu Ser Gly Lys Phe Asn 
                325                 330                 335     


Leu Glu Asp Glu Lys Arg Ala Glu Leu Lys Gly Asn Ala Thr Ser Val 
            340                 345                 350         


Ile Leu Ala Arg Lys Asp Leu Phe Gly Asp Ala Trp Ala Gly Phe Asp 
        355                 360                 365             


Ala Ala Val Gln Asp Glu Ile Val Trp Arg Leu Val Ser Gln Glu Ser 
    370                 375                 380                 


Glu Gly Ala Leu Ile Ala Trp Leu Gln Gln His Thr Gly Val Asp Gly 
385                 390                 395                 400 


Val Cys Ala Glu Ala Ile Val Asn Thr Arg Leu Pro Asp Gly Tyr Gly 
                405                 410                 415     


Arg Leu Ser Arg Lys Ala Leu Glu Arg Ile Val Pro Ala Leu Gln Arg 
            420                 425                 430         


Glu Val Cys Thr Tyr Asp Lys Ala Val Gln Ala Ala Gly Phe Ala His 
        435                 440                 445             


His Ser Asp Leu Gly Phe Asp Phe Asp Tyr Ala Glu Asp Glu Val Gln 
    450                 455                 460                 


Gln Val Gly Glu His Thr Ile Ala Ser Thr Gly Glu Val Gln Ala Gln 
465                 470                 475                 480 


Tyr Ala Phe Lys Gln Leu Pro Tyr Tyr Gly Lys Ala Leu Gln Arg His 
                485                 490                 495     


Val Ala Phe Gly Ser Gly Asp Ala Lys Asp His Glu Glu Lys Cys Tyr 
            500                 505                 510         


Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu Asn Gln Val Arg 
        515                 520                 525             


Thr Val Val Asn Ala Leu Ile Arg Arg Tyr Gly His Pro Thr Glu Val 
    530                 535                 540                 


Val Val Glu Leu Ala Arg Asp Leu Lys Gln Ser Arg Glu Gln Lys Gln 
545                 550                 555                 560 


Gln Thr Gln Arg Glu Gln Ala Asp Asn Gln Lys Arg Asn Glu Asp Ile 
                565                 570                 575     


Arg Lys Arg Ile Ala Pro Ile Leu Glu Thr Ser Pro Glu Arg Val Arg 
            580                 585                 590         


Asp Arg Asp Ile Lys Lys Trp Ile Leu Trp Glu Glu Leu Asn Lys Lys 
        595                 600                 605             


Asp Ile Ala Asp Arg His Cys Pro Tyr Ser Gly Glu Arg Ile Ser Ala 
    610                 615                 620                 


Thr Met Leu Leu Ser Glu Ala Val Glu Ile Glu His Ile Leu Pro Phe 
625                 630                 635                 640 


Ser Arg Thr Leu Asp Asp Ser Leu Asn Asn Arg Thr Val Ala Met Arg 
                645                 650                 655     


Arg Ala Asn Arg Ile Lys Gly Asp Arg Thr Pro Trp Glu Ala Arg Ala 
            660                 665                 670         


Asp Phe Glu Ala Gln Gly Trp Arg Tyr Glu Ala Ile Leu Gln Arg Ala 
        675                 680                 685             


Glu Gly Met Pro Pro Arg Lys Arg Tyr Arg Phe Ala Glu Asp Gly Tyr 
    690                 695                 700                 


Gln Arg Trp Leu Gly Lys Asp Arg Asn Phe Leu Ala Arg Ala Leu Asn 
705                 710                 715                 720 


Asp Thr Ser Tyr Leu Ser Arg Leu Ala Ala Asn Tyr Leu Arg Leu Val 
                725                 730                 735     


Cys Pro Gln Gly Val Arg Val Ile Pro Gly Gln Met Thr Asp Lys Leu 
            740                 745                 750         


Arg Gly Lys Phe Gly Leu Asn Ser Val Leu Gly Leu Asp Gly Lys Lys 
        755                 760                 765             


Asn Arg Asn Asp His Arg His His Ala Val Asp Ala Cys Val Ile Gly 
    770                 775                 780                 


Val Thr Asp Gln Gly Leu Met Gln Arg Phe Ala Asn Ala Ser Lys Gln 
785                 790                 795                 800 


Ala Arg Glu Asn Gly Leu Thr Arg Leu Val Gln Asp Met Leu Leu Pro 
                805                 810                 815     


Trp Trp Pro Ser Tyr Tyr Asp His Val Glu Arg Ala Val Arg Ile Arg 
            820                 825                 830         


Val Ser His Arg Pro Asp His Gly Phe Glu Gly Ala Met Met Lys Gly 
        835                 840                 845             


Thr Ala His Gly Ile Arg Glu Asp Gly Ile Arg Glu Asp Gly Arg Ile 
    850                 855                 860                 


Lys Gln Arg Pro Lys Ala Lys Gly Ser Ala Asp His Lys Thr Ile Thr 
865                 870                 875                 880 


Leu Ile Pro Ile Asp Glu Pro Arg Gln Leu Ala Arg His Gly Val Asp 
                885                 890                 895     


Ala Glu Gly Lys Pro Leu Pro Tyr Lys Gly Tyr Ala Ser Gly Ser Asn 
            900                 905                 910         


Tyr Cys Ile Glu Ile Thr Lys Asn Gly Lys Gly Lys Trp Glu Gly Gln 
        915                 920                 925             


Val Ile Ser Thr Phe Asp Ala Tyr Arg Ile Lys Ala Ala Ala Asp Ala 
    930                 935                 940                 


Ala Ala Arg Ala Gly Gln Val Ile Ser Thr Val Glu Ala Asp Ser Ile 
945                 950                 955                 960 


Val Arg Lys Ser Gly Trp Glu Arg Leu Arg Gly Ala Gln Ser Gln Asn 
                965                 970                 975     


Gly Gln Pro Leu Val Met Arg Leu Val Ile Gly Asp Ser Val Arg Met 
            980                 985                 990         


Glu Val Asp Gly Arg Asp Glu Val  Met Arg Val Val Lys  Met Ser Gly 
        995                 1000                 1005             


Lys Glu  Met Val Phe Ala Pro  Val Arg Glu Ala Asn  Val Asp Lys 
    1010                 1015                 1020             


Arg Asn  Asn Met Pro Asp Glu  Gln Asp Pro Phe Thr  Tyr Thr Tyr 
    1025                 1030                 1035             


Lys Arg  Ala Asp Gln Leu Arg  Lys Ala Lys Ala Arg  Gln Val Thr 
    1040                 1045                 1050             


Ile Ser  Pro Ile Gly Glu Leu  Arg Asp Pro Gly Phe  Lys Gly 
    1055                 1060                 1065         


<210>  71
<211>  1059
<212>  PRT
<213>  Wolinella succinogenes

<400>  71

Met Ile Glu Arg Ile Leu Gly Val Asp Leu Gly Ile Ser Ser Leu Gly 
1               5                   10                  15      


Trp Ala Ile Val Glu Tyr Asp Lys Asp Asp Glu Ala Ala Asn Arg Ile 
            20                  25                  30          


Ile Asp Cys Gly Val Arg Leu Phe Thr Ala Ala Glu Thr Pro Lys Lys 
        35                  40                  45              


Lys Glu Ser Pro Asn Lys Ala Arg Arg Glu Ala Arg Gly Ile Arg Arg 
    50                  55                  60                  


Val Leu Asn Arg Arg Arg Val Arg Met Asn Met Ile Lys Lys Leu Phe 
65                  70                  75                  80  


Leu Arg Ala Gly Leu Ile Gln Asp Val Asp Leu Asp Gly Glu Gly Gly 
                85                  90                  95      


Met Phe Tyr Ser Lys Ala Asn Arg Ala Asp Val Trp Glu Leu Arg His 
            100                 105                 110         


Asp Gly Leu Tyr Arg Leu Leu Lys Gly Asp Glu Leu Ala Arg Val Leu 
        115                 120                 125             


Ile His Ile Ala Lys His Arg Gly Tyr Lys Phe Ile Gly Asp Asp Glu 
    130                 135                 140                 


Ala Asp Glu Glu Ser Gly Lys Val Lys Lys Ala Gly Val Val Leu Arg 
145                 150                 155                 160 


Gln Asn Phe Glu Ala Ala Gly Cys Arg Thr Val Gly Glu Trp Leu Trp 
                165                 170                 175     


Arg Glu Arg Gly Ala Asn Gly Lys Lys Arg Asn Lys His Gly Asp Tyr 
            180                 185                 190         


Glu Ile Ser Ile His Arg Asp Leu Leu Val Glu Glu Val Glu Ala Ile 
        195                 200                 205             


Phe Val Ala Gln Gln Glu Met Arg Ser Thr Ile Ala Thr Asp Ala Leu 
    210                 215                 220                 


Lys Ala Ala Tyr Arg Glu Ile Ala Phe Phe Val Arg Pro Met Gln Arg 
225                 230                 235                 240 


Ile Glu Lys Met Val Gly His Cys Thr Tyr Phe Pro Glu Glu Arg Arg 
                245                 250                 255     


Ala Pro Lys Ser Ala Pro Thr Ala Glu Lys Phe Ile Ala Ile Ser Lys 
            260                 265                 270         


Phe Phe Ser Thr Val Ile Ile Asp Asn Glu Gly Trp Glu Gln Lys Ile 
        275                 280                 285             


Ile Glu Arg Lys Thr Leu Glu Glu Leu Leu Asp Phe Ala Val Ser Arg 
    290                 295                 300                 


Glu Lys Val Glu Phe Arg His Leu Arg Lys Phe Leu Asp Leu Ser Asp 
305                 310                 315                 320 


Asn Glu Ile Phe Lys Gly Leu His Tyr Lys Gly Lys Pro Lys Thr Ala 
                325                 330                 335     


Lys Lys Arg Glu Ala Thr Leu Phe Asp Pro Asn Glu Pro Thr Glu Leu 
            340                 345                 350         


Glu Phe Asp Lys Val Glu Ala Glu Lys Lys Ala Trp Ile Ser Leu Arg 
        355                 360                 365             


Gly Ala Ala Lys Leu Arg Glu Ala Leu Gly Asn Glu Phe Tyr Gly Arg 
    370                 375                 380                 


Phe Val Ala Leu Gly Lys His Ala Asp Glu Ala Thr Lys Ile Leu Thr 
385                 390                 395                 400 


Tyr Tyr Lys Asp Glu Gly Gln Lys Arg Arg Glu Leu Thr Lys Leu Pro 
                405                 410                 415     


Leu Glu Ala Glu Met Val Glu Arg Leu Val Lys Ile Gly Phe Ser Asp 
            420                 425                 430         


Phe Leu Lys Leu Ser Leu Lys Ala Ile Arg Asp Ile Leu Pro Ala Met 
        435                 440                 445             


Glu Ser Gly Ala Arg Tyr Asp Glu Ala Val Leu Met Leu Gly Val Pro 
    450                 455                 460                 


His Lys Glu Lys Ser Ala Ile Leu Pro Pro Leu Asn Lys Thr Asp Ile 
465                 470                 475                 480 


Asp Ile Leu Asn Pro Thr Val Ile Arg Ala Phe Ala Gln Phe Arg Lys 
                485                 490                 495     


Val Ala Asn Ala Leu Val Arg Lys Tyr Gly Ala Phe Asp Arg Val His 
            500                 505                 510         


Phe Glu Leu Ala Arg Glu Ile Asn Thr Lys Gly Glu Ile Glu Asp Ile 
        515                 520                 525             


Lys Glu Ser Gln Arg Lys Asn Glu Lys Glu Arg Lys Glu Ala Ala Asp 
    530                 535                 540                 


Trp Ile Ala Glu Thr Ser Phe Gln Val Pro Leu Thr Arg Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Arg Leu Tyr Ile Gln Gln Asp Gly Arg Cys Ala Tyr Thr 
                565                 570                 575     


Gly Asp Val Ile Glu Leu Glu Arg Leu Phe Asp Glu Gly Tyr Cys Glu 
            580                 585                 590         


Ile Asp His Ile Leu Pro Arg Ser Arg Ser Ala Asp Asp Ser Phe Ala 
        595                 600                 605             


Asn Lys Val Leu Cys Leu Ala Arg Ala Asn Gln Gln Lys Thr Asp Arg 
    610                 615                 620                 


Thr Pro Tyr Glu Trp Phe Gly His Asp Ala Ala Arg Trp Asn Ala Phe 
625                 630                 635                 640 


Glu Thr Arg Thr Ser Ala Pro Ser Asn Arg Val Arg Thr Gly Lys Gly 
                645                 650                 655     


Lys Ile Asp Arg Leu Leu Lys Lys Asn Phe Asp Glu Asn Ser Glu Met 
            660                 665                 670         


Ala Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Met Ala Arg Ala 
        675                 680                 685             


Ile Lys Thr Tyr Cys Glu Gln Tyr Trp Val Phe Lys Asn Ser His Thr 
    690                 695                 700                 


Lys Ala Pro Val Gln Val Arg Ser Gly Lys Leu Thr Ser Val Leu Arg 
705                 710                 715                 720 


Tyr Gln Trp Gly Leu Glu Ser Lys Asp Arg Glu Ser His Thr His His 
                725                 730                 735     


Ala Val Asp Ala Ile Ile Ile Ala Phe Ser Thr Gln Gly Met Val Gln 
            740                 745                 750         


Lys Leu Ser Glu Tyr Tyr Arg Phe Lys Glu Thr His Arg Glu Lys Glu 
        755                 760                 765             


Arg Pro Lys Leu Ala Val Pro Leu Ala Asn Phe Arg Asp Ala Val Glu 
    770                 775                 780                 


Glu Ala Thr Arg Ile Glu Asn Thr Glu Thr Val Lys Glu Gly Val Glu 
785                 790                 795                 800 


Val Lys Arg Leu Leu Ile Ser Arg Pro Pro Arg Ala Arg Val Thr Gly 
                805                 810                 815     


Gln Ala His Glu Gln Thr Ala Lys Pro Tyr Pro Arg Ile Lys Gln Val 
            820                 825                 830         


Lys Asn Lys Lys Lys Trp Arg Leu Ala Pro Ile Asp Glu Glu Lys Phe 
        835                 840                 845             


Glu Ser Phe Lys Ala Asp Arg Val Ala Ser Ala Asn Gln Lys Asn Phe 
    850                 855                 860                 


Tyr Glu Thr Ser Thr Ile Pro Arg Val Asp Val Tyr His Lys Lys Gly 
865                 870                 875                 880 


Lys Phe His Leu Val Pro Ile Tyr Leu His Glu Met Val Leu Asn Glu 
                885                 890                 895     


Leu Pro Asn Leu Ser Leu Gly Thr Asn Pro Glu Ala Met Asp Glu Asn 
            900                 905                 910         


Phe Phe Lys Phe Ser Ile Phe Lys Asp Asp Leu Ile Ser Ile Gln Thr 
        915                 920                 925             


Gln Gly Thr Pro Lys Lys Pro Ala Lys Ile Ile Met Gly Tyr Phe Lys 
    930                 935                 940                 


Asn Met His Gly Ala Asn Met Val Leu Ser Ser Ile Asn Asn Ser Pro 
945                 950                 955                 960 


Cys Glu Gly Phe Thr Cys Thr Pro Val Ser Met Asp Lys Lys His Lys 
                965                 970                 975     


Asp Lys Cys Lys Leu Cys Pro Glu Glu Asn Arg Ile Ala Gly Arg Cys 
            980                 985                 990         


Leu Gln Gly Phe Leu Asp Tyr Trp  Ser Gln Glu Gly Leu  Arg Pro Pro 
        995                 1000                 1005             


Arg Lys  Glu Phe Glu Cys Asp  Gln Gly Val Lys Phe  Ala Leu Asp 
    1010                 1015                 1020             


Val Lys  Lys Tyr Gln Ile Asp  Pro Leu Gly Tyr Tyr  Tyr Glu Val 
    1025                 1030                 1035             


Lys Gln  Glu Lys Arg Leu Gly  Thr Ile Pro Gln Met  Arg Ser Ala 
    1040                 1045                 1050             


Lys Lys  Leu Val Lys Lys 
    1055                 


<210>  72
<211>  1368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 1"

<400>  72

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  73
<211>  1187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 2"

<400>  73

Met Leu Ser Arg Gln Leu Leu Gly Ala Ser His Leu Ala Arg Pro Val 
1               5                   10                  15      


Ser Tyr Ser Tyr Asn Val Gln Asp Asn Asp Val His Cys Ser Tyr Gly 
            20                  25                  30          


Glu Arg Cys Phe Met Arg Gly Lys Arg Tyr Arg Ile Gly Ile Asp Val 
        35                  40                  45              


Gly Leu Asn Ser Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn 
    50                  55                  60                  


Ser Pro Val Arg Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly 
65                  70                  75                  80  


Val Asp Pro Gln Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser 
                85                  90                  95      


Gly Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg 
            100                 105                 110         


Leu His Lys Leu Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile 
        115                 120                 125             


Glu Pro Glu Ser Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala 
    130                 135                 140                 


Glu Leu Ala Thr Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser 
145                 150                 155                 160 


Ile Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn 
                165                 170                 175     


Pro Tyr Arg Gln Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys 
            180                 185                 190         


Gln Tyr Gly Glu Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala 
        195                 200                 205             


Thr Ala Ala Glu Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met 
    210                 215                 220                 


Leu Asp Ala Gly Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly 
225                 230                 235                 240 


Ser Lys Lys Pro Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln 
                245                 250                 255     


Glu Asp Asn Ala Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val 
            260                 265                 270         


Pro Ala Asp Glu Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val 
        275                 280                 285             


Ser Pro Lys Gly Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala 
    290                 295                 300                 


Pro Glu Gln Ala Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr 
305                 310                 315                 320 


Arg Ile Ala Asn Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala 
                325                 330                 335     


Glu Leu Arg Lys Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln 
            340                 345                 350         


Leu Val Ser Pro Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp 
        355                 360                 365             


Phe Leu Gly Phe Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr 
    370                 375                 380                 


Glu Asp Gly Glu Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser 
385                 390                 395                 400 


Val Gln Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val 
                405                 410                 415     


Ala Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg 
            420                 425                 430         


Leu Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala 
        435                 440                 445             


Tyr Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu 
    450                 455                 460                 


Thr Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser 
465                 470                 475                 480 


Val Glu Thr Leu Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp 
                485                 490                 495     


Asp Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp 
            500                 505                 510         


Arg Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val 
        515                 520                 525             


Asp Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln 
    530                 535                 540                 


Arg Trp Gly Asn Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser 
545                 550                 555                 560 


Phe Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys 
                565                 570                 575     


Asn Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu 
            580                 585                 590         


Arg Ala Asp Glu Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg 
        595                 600                 605             


Leu Glu Ala Ile Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg 
    610                 615                 620                 


Thr Ile Thr Phe Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys 
625                 630                 635                 640 


Gly Val Gly Ser Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala 
                645                 650                 655     


Glu Cys Asn Arg Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg 
            660                 665                 670         


Ser Glu Asp Ala Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys 
        675                 680                 685             


Arg Val Thr Met Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu 
    690                 695                 700                 


Val Lys Ala Phe Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu 
705                 710                 715                 720 


Asp Asp Ala Ala Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met 
                725                 730                 735     


Ala Asp Glu Leu His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln 
            740                 745                 750         


Tyr Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys 
        755                 760                 765             


Thr Thr Val Ser Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg 
    770                 775                 780                 


Ala Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys 
785                 790                 795                 800 


Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala 
                805                 810                 815     


Met Met Asn Thr Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu 
            820                 825                 830         


Arg Glu Ser Gln Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp 
        835                 840                 845             


Lys Glu Tyr Pro Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu 
    850                 855                 860                 


Trp Leu Asp Asn Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu 
865                 870                 875                 880 


Asp Asn Asp Arg Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly 
                885                 890                 895     


Asn Ser Ile Ala His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro 
            900                 905                 910         


Leu Gly Ser Ala Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro 
        915                 920                 925             


Ala Leu Trp Cys Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu 
    930                 935                 940                 


Gly Leu Pro Glu Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg 
945                 950                 955                 960 


Tyr Ser Ala Asp Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln 
                965                 970                 975     


Ile Ala Val Gln Glu Gly Ser Ala Asp Ile Gly Ser Ala Ile His His 
            980                 985                 990         


Ala Arg Val Tyr Arg Cys Trp Lys  Thr Asn Ala Lys Gly  Val Arg Lys 
        995                 1000                 1005             


Tyr Phe  Tyr Gly Met Ile Arg  Val Phe Gln Thr Asp  Leu Leu Arg 
    1010                 1015                 1020             


Ala Cys  His Asp Asp Leu Phe  Thr Val Pro Leu Pro  Pro Gln Ser 
    1025                 1030                 1035             


Ile Ser  Met Arg Tyr Gly Glu  Pro Arg Val Val Gln  Ala Leu Gln 
    1040                 1045                 1050             


Ser Gly  Asn Ala Gln Tyr Leu  Gly Ser Leu Val Val  Gly Asp Glu 
    1055                 1060                 1065             


Ile Glu  Met Asp Phe Ser Ser  Leu Asp Val Asp Gly  Gln Ile Gly 
    1070                 1075                 1080             


Glu Tyr  Leu Gln Phe Phe Ser  Gln Phe Ser Gly Gly  Asn Leu Ala 
    1085                 1090                 1095             


Trp Lys  His Trp Val Val Asp  Gly Phe Phe Asn Gln  Thr Gln Leu 
    1100                 1105                 1110             


Arg Ile  Arg Pro Arg Tyr Leu  Ala Ala Glu Gly Leu  Ala Lys Ala 
    1115                 1120                 1125             


Phe Ser  Asp Asp Val Val Pro  Asp Gly Val Gln Lys  Ile Val Thr 
    1130                 1135                 1140             


Lys Gln  Gly Trp Leu Pro Pro  Val Asn Thr Ala Ser  Lys Thr Ala 
    1145                 1150                 1155             


Val Arg  Ile Val Arg Arg Asn  Ala Phe Gly Glu Pro  Arg Leu Ser 
    1160                 1165                 1170             


Ser Ala  His His Met Pro Cys  Ser Trp Gln Trp Arg  His Glu 
    1175                 1180                 1185         


<210>  74
<211>  1274
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 3"

<400>  74

Met Asn Ile Asn Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr 
1               5                   10                  15      


Ile Gly Leu Asp Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp 
            20                  25                  30          


Asn Glu Thr Asn Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln 
        35                  40                  45              


Ala Lys Thr Ala Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu 
    50                  55                  60                  


Ile Arg Arg Arg Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp 
65                  70                  75                  80  


Lys Tyr Asn Ser Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn 
                85                  90                  95      


Asn Tyr Gln Glu Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys 
            100                 105                 110         


Leu Glu Ala Leu Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile 
        115                 120                 125             


Leu His Asp Tyr Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg 
    130                 135                 140                 


Asp Phe Asn Val Tyr Pro Thr Glu Glu Leu Ala Asn Tyr Phe Asp Glu 
145                 150                 155                 160 


Phe Gly Tyr Tyr Lys Gly Ile Ile Asp Ser Lys Asn Asp Asp Asp Asp 
                165                 170                 175     


Lys Leu Glu Glu Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gln His Trp 
            180                 185                 190         


Leu Glu Glu Val Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu 
        195                 200                 205             


Lys Phe Lys Glu Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr 
    210                 215                 220                 


Ser Glu Gly Pro Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr 
225                 230                 235                 240 


His Leu Asp Glu Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile 
                245                 250                 255     


Trp Asp Lys Thr Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg 
            260                 265                 270         


Ala Pro Lys Asn Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu 
        275                 280                 285             


Leu Ser Thr Ile Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile 
    290                 295                 300                 


Asn Gln Glu Phe Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu 
305                 310                 315                 320 


Ile Lys Thr Asn Ser Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys 
                325                 330                 335     


Leu Arg Glu Glu Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys 
            340                 345                 350         


Asp Val Glu Ser Glu Glu Lys Leu Glu Lys Asp Asp His Lys Trp Lys 
        355                 360                 365             


Leu Lys Gly Leu Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp 
    370                 375                 380                 


Leu Ser Ser Leu Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys 
385                 390                 395                 400 


Leu Asp Phe Leu Leu Glu Asp Gln Tyr Thr Pro Leu Asp Lys Ile Asn 
                405                 410                 415     


Phe Leu Gln Ser Leu Tyr Val Tyr Leu Gly Lys His Leu Arg Tyr Ser 
            420                 425                 430         


Asn Arg Val Asp Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Ser Arg 
        435                 440                 445             


Leu Phe Glu Arg Val Leu Gln Glu Gln Lys Asp Gly Leu Phe Lys Leu 
    450                 455                 460                 


Phe Glu Gln Thr Asp Lys Asp Asp Glu Lys Ile Leu Thr Gln Thr His 
465                 470                 475                 480 


Ser Leu Ser Thr Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn 
                485                 490                 495     


Leu Asp Asn Asp Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn 
            500                 505                 510         


Phe Glu Ala Ile Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys 
        515                 520                 525             


Thr Asn Asn Asn Leu Ser Leu Lys Gln Asp Lys Arg Tyr Leu Asp Asp 
    530                 535                 540                 


Gln Phe Ile Asn Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu 
545                 550                 555                 560 


Arg Glu Ala Thr Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu 
                565                 570                 575     


Glu Tyr Asp Val Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser 
            580                 585                 590         


Glu Glu Lys Glu Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys 
        595                 600                 605             


Lys Asn Gly Asp Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ala 
    610                 615                 620                 


Glu Asp Lys Ile Glu Glu Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys 
625                 630                 635                 640 


Val Leu Leu Trp Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Gln Lys 
                645                 650                 655     


Glu Ile Ala Phe Asp Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile 
            660                 665                 670         


Asp His Ile Ile Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn 
        675                 680                 685             


Lys Leu Leu Val Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr 
    690                 695                 700                 


Pro Tyr Glu Phe Ile Asn Ser Gly Lys Ala Glu Ile Thr Trp Glu Val 
705                 710                 715                 720 


Tyr Glu Ala Tyr Cys His Lys Phe Lys Asn Gly Asp Ser Ser Leu Leu 
                725                 730                 735     


Asp Ser Thr Gln Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp 
            740                 745                 750         


Thr Ser Ser Lys Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp 
        755                 760                 765             


Thr Arg Tyr Ala Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala 
    770                 775                 780                 


Asn Asn His Leu Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile 
785                 790                 795                 800 


Asn Gly Gly Val Thr Ser Phe Leu Arg Lys Asn Phe Asp Pro Lys Ser 
                805                 810                 815     


Trp Tyr Ala Lys Lys Asp Arg Asp Lys Asn Ile His His Ala Val Asp 
            820                 825                 830         


Ala Ser Ile Ile Ser Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn 
        835                 840                 845             


Gln Leu Thr Lys Phe Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly 
    850                 855                 860                 


Ser Trp Lys Lys Ile Asp Pro Lys Thr Gly Val Val Ser Glu Val Thr 
865                 870                 875                 880 


Asp Glu Asn Trp Lys Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile 
                885                 890                 895     


Ala Lys Val Ile Asp Lys Tyr Ile Gln Asp Ser Asn Ile Glu Arg Lys 
            900                 905                 910         


Ala Arg Tyr Ser Arg Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe 
        915                 920                 925             


Asn Asp Thr Val Tyr Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile 
    930                 935                 940                 


Lys Arg Lys Asn Leu Lys Thr Leu Asp Ile His Glu Ser Ala Glu Glu 
945                 950                 955                 960 


Asn Lys Asn Ser Lys Val Lys Lys Gln Phe Val Tyr Arg Lys Leu Val 
                965                 970                 975     


Asn Val Ser Leu Leu Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu 
            980                 985                 990         


Lys Glu Asp Ile Leu Met Tyr Arg  Ala Asn Pro Trp Val  Ile Asn Leu 
        995                 1000                 1005             


Ala Glu  Gln Ile Phe Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys 
    1010                 1015                 1020             


Ser Gln  Asn Val Phe Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu 
    1025                 1030                 1035             


Phe Pro  Glu Lys Phe Ser Glu  Ala Phe Val Lys Ser  Met Ile Arg 
    1040                 1045                 1050             


Asn Lys  Thr Ala Ile Ile Tyr  Asn Val Glu Lys Asp  Val Val His 
    1055                 1060                 1065             


Arg Ile  Lys Arg Leu Lys Ile  Leu Ser Ser Glu Leu  Lys Glu Asn 
    1070                 1075                 1080             


Lys Trp  Ser Asn Val Ile Ile  Arg Ser Lys Asn Glu  Ser Gly Thr 
    1085                 1090                 1095             


Lys Leu  Ser Tyr Gln Asp Thr  Ile Asn Ser Ile Ala  Leu Met Ile 
    1100                 1105                 1110             


Met Arg  Ser Ile Asp Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val 
    1115                 1120                 1125             


Pro Leu  Asn Thr Leu Asn Leu  His Leu Gly Asp Gln  Asp Phe Asp 
    1130                 1135                 1140             


Leu His  Asn Ile Asp Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys 
    1145                 1150                 1155             


Tyr Leu  Lys Ala Asn Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg 
    1160                 1165                 1170             


Val Leu  Thr Ser Gly Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys 
    1175                 1180                 1185             


Leu Met  Tyr Ile Ser Ser Phe  Gln Asn Leu Asn Asp  Leu Ile Glu 
    1190                 1195                 1200             


Ile Lys  Asn Leu Ile Glu Thr  Glu Tyr Lys Glu Asn  Val Asp Ser 
    1205                 1210                 1215             


Asp Pro  Lys Lys Lys Lys Lys  Ala Ser Gln Ile Leu  Arg Ser Leu 
    1220                 1225                 1230             


Ser Val  Ile Leu Asn Asp Tyr  Ile Leu Leu Asp Ala  Lys Tyr Asn 
    1235                 1240                 1245             


Phe Asp  Ile Leu Gly Leu Ser  Lys Asn Lys Ile Asp  Glu Ile Leu 
    1250                 1255                 1260             


Asn Ser  Lys Leu Asp Leu Asp  Lys Ile Ala Lys 
    1265                 1270                 


<210>  75
<211>  984
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 4"

<400>  75

Met Ala Lys Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Ile Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ile Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Leu Tyr Thr Lys Asp Asp Leu 
        275                 280                 285             


Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu Thr Tyr Lys 
    290                 295                 300                 


Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu Phe Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Asn Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu Phe Ile 
                325                 330                 335     


Lys Ala Leu Gly Glu His Ser Leu Ser Gln Asp Asp Leu Asn Glu Ile 
            340                 345                 350         


Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu Lys Lys Ala 
        355                 360                 365             


Leu Ala Lys Tyr Asp Leu Asn Glu Asn Gln Ile Asp Asn Leu Ser Lys 
    370                 375                 380                 


Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Leu Lys Leu 
385                 390                 395                 400 


Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu Ala Cys Asn 
                405                 410                 415     


Glu Leu Thr Leu Lys Val Ala Ile Asn Glu Asp Lys Lys Asp Phe Leu 
            420                 425                 430         


Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr Asn Pro Val 
        435                 440                 445             


Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu 
    450                 455                 460                 


Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Ala Arg Glu 
465                 470                 475                 480 


Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys Glu Gln Asn 
                485                 490                 495     


Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu Lys Leu 
            500                 505                 510         


Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu Phe Lys 
        515                 520                 525             


Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile Lys Leu Ser 
    530                 535                 540                 


Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile Tyr Pro Tyr 
545                 550                 555                 560 


Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu Val Phe Thr 
                565                 570                 575     


Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu Ala Phe Gly 
            580                 585                 590         


Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala Lys Asn Leu 
        595                 600                 605             


Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr Lys Asp Lys 
    610                 615                 620                 


Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile 
625                 630                 635                 640 


Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp Phe Leu Pro 
                645                 650                 655     


Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln Lys Gly Ser 
            660                 665                 670         


Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Ala Leu Arg 
        675                 680                 685             


His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu His His 
    690                 695                 700                 


Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser Ile Val Lys 
705                 710                 715                 720 


Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Thr Ala Glu Leu 
                725                 730                 735     


Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys Arg Lys Phe 
            740                 745                 750         


Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp Lys Ile Asp 
        755                 760                 765             


Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala Leu 
    770                 775                 780                 


His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln Ser Tyr Gly 
785                 790                 795                 800 


Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg Lys 
                805                 810                 815     


Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val Asp Ile 
            820                 825                 830         


Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr Thr 
        835                 840                 845             


Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala Arg Ser 
    850                 855                 860                 


Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn Tyr Glu 
865                 870                 875                 880 


Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gln Thr Lys 
                885                 890                 895     


Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe Thr Ser Ser 
            900                 905                 910         


Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu Thr Leu 
        915                 920                 925             


Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys Glu Val 
    930                 935                 940                 


Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe Glu Lys Tyr 
945                 950                 955                 960 


Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe Arg Gln Arg 
                965                 970                 975     


Glu Glu Phe Lys Asn Glu Leu Arg 
            980                 


<210>  76
<211>  1082
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 5"

<400>  76

Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Thr Thr 
    290                 295                 300                 


Leu Ile Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Glu Leu Asp Asn Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Asp Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Thr Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  77
<211>  984
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 6"

<400>  77

Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Ile Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Leu Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Thr Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Val Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210>  78
<211>  1136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 7"

<400>  78

Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asp Thr Gly Lys Ile Ile His Ala Ser Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Ser 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Asn Arg Arg Lys Lys His Arg Ser Val 
    50                  55                  60                  


Arg Leu Gln Asp Leu Phe Glu Gly Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Met Asn Leu Asn Pro Tyr Gln Leu Arg Val Gln Gly Met 
                85                  90                  95      


Glu Asn Gln Leu Thr Asn Glu Glu Leu Phe Val Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asn Gly Glu 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Ser Lys Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Ile Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Thr Glu Glu Tyr Arg Ala Ser Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Leu Ile 
    290                 295                 300                 


Ile Glu Tyr Ala Lys Ser Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gln Ile Arg Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Lys Val Glu Glu Leu Pro 
        355                 360                 365             


Arg Lys Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Ser Lys Leu Lys Asp Ile Phe 
385                 390                 395                 400 


Asn Arg Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Ile Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Arg Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys Tyr Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Asn Ile Phe His Gly His Lys Glu 
545                 550                 555                 560 


Leu Thr Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Asn Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Ser Lys Leu Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ser His 
    690                 695                 700                 


Gln Leu Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Ile Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys His Ser Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Glu Thr Gly Glu Ile Val Ser Leu Ser Asp Glu Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


Arg Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr Lys Thr Pro Ser Lys Thr 
    850                 855                 860                 


Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Lys Thr Asp Lys Ser Gln Phe 
865                 870                 875                 880 


Leu Met Tyr Gln Lys Asp Arg Lys Thr Trp Asp Glu Val Ile Glu Lys 
                885                 890                 895     


Ile Ile Glu Gln Tyr Arg Pro Phe Lys Glu Tyr Asp Lys Asn Gly Lys 
            900                 905                 910         


Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg Ile Gly Asn Gly Pro 
        915                 920                 925             


Ile Arg Lys Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu 
    930                 935                 940                 


Lys Tyr Tyr Asp Ile Leu Leu Gly Lys His Lys Asn Ile Thr Pro Asp 
945                 950                 955                 960 


Gly Ser Arg Asn Thr Val Ala Leu Leu Ser Leu Asn Pro Trp Arg Thr 
                965                 970                 975     


Asp Val Tyr Tyr Asn Ser Glu Thr Lys Lys Tyr Glu Phe Leu Gly Leu 
            980                 985                 990         


Lys Tyr Ala Asp Leu Cys Phe Glu  Glu Gly Gly Ala Tyr  Gly Ile Ser 
        995                 1000                 1005             


Glu Val  Lys Tyr Lys Lys Ile  Arg Glu Lys Glu Gly  Ile Gly Lys 
    1010                 1015                 1020             


Asn Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu 
    1025                 1030                 1035             


Ile Lys  Asp Thr Glu Thr Asn  Cys Gln Gln Phe Phe  Arg Phe Trp 
    1040                 1045                 1050             


Ser Arg  Thr Gly Lys Asp Asn  Pro Lys Ser Phe Glu  Lys His Lys 
    1055                 1060                 1065             


Ile Glu  Leu Lys Pro Tyr Glu  Lys Ala Lys Phe Glu  Lys Gly Glu 
    1070                 1075                 1080             


Glu Leu  Lys Val Leu Gly Lys  Val Pro Pro Ser Ser  Asn Gln Phe 
    1085                 1090                 1095             


Gln Lys  Asn Met Gln Ile Glu  Asn Leu Ser Ile Tyr  Lys Val Lys 
    1100                 1105                 1110             


Thr Asp  Ile Leu Gly Asn Lys  His Phe Ile Lys Lys  Glu Gly Asp 
    1115                 1120                 1125             


Glu Pro  Lys Leu Lys Phe Lys  Lys 
    1130                 1135     


<210>  79
<211>  1371
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 8"

<400>  79

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Ile Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Thr Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Met Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210>  80
<211>  1348
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 9"

<400>  80

Met Lys Lys Pro Tyr Thr Ile Ala Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Val Val Val Thr Asp Asp Tyr Arg Val Pro Thr Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Glu Arg Lys Thr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asp Thr Ala Glu Gly Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Lys Glu Ile Phe Thr Glu Glu Met Ala Lys Val Asp Asp Gly 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Asp Ser Phe Tyr Val Leu Glu Asp Lys Glu 
            100                 105                 110         


Gly Asn Lys His Pro Ile Phe Ala Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Lys Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Val Asp 
    130                 135                 140                 


Asn Pro Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Val Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Thr Leu Ser Ser 
                165                 170                 175     


Lys Asn Asn Asn Leu Gln Lys Ser Phe Asp His Leu Val Asp Thr Tyr 
            180                 185                 190         


Asn Leu Leu Phe Glu Glu Gln Arg Leu Leu Thr Glu Gly Ile Asn Ala 
        195                 200                 205             


Lys Glu Leu Leu Ser Ala Ala Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ser Leu Ile Pro Gly Gln Lys Lys Thr Gly Ile Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ala Asn Phe 
                245                 250                 255     


Gly Leu Ser Lys Asp Val Lys Leu Gln Leu Ala Lys Asp Thr Tyr Ala 
            260                 265                 270         


Asp Asp Leu Asp Ser Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Thr Glu Ser Asp Glu Ile Thr Arg Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Arg Glu His His Lys Asp Leu Val Thr Leu Lys 
                325                 330                 335     


Thr Leu Ile Lys Asp Gln Leu Pro Glu Lys Tyr Gln Glu Ile Phe Leu 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Gln Val Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Leu Lys Pro Ile Leu Ala Arg Leu Asp 
    370                 375                 380                 


Gly Ser Glu Pro Leu Leu Leu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Glu Glu Leu His Ala Ile Leu Arg Arg Gln Glu Val Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Lys Lys Ile Glu Ser Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly His Ser Arg Phe Ala Trp 
    450                 455                 460                 


Val Lys Arg Lys Phe Asp Gly Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Ile Val Asp Glu Glu Ala Ser Ala Gln Ile Phe Ile Glu Lys Met Thr 
                485                 490                 495     


Lys Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Ala Thr Glu Gly Met Thr Arg Pro Gln Phe Leu Ser Ala Asp Gln 
    530                 535                 540                 


Lys Gln Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asn Tyr Phe Lys Lys Ile Glu Cys Trp Asp 
                565                 570                 575     


Ser Val Glu Ile Thr Gly Val Glu Asp Ser Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Gln Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Pro Asp Asn Gln Lys Ile Ile Glu Asp Ile Ile Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Lys Met Ile Ser Lys Arg Leu Asp Gln Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Lys Val Val Leu Asn Lys Leu Glu Arg His His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gly Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Ser Glu Leu Ser Phe 
    690                 695                 700                 


Ile Asp Glu Ile Ala Lys Ala Gln Val Ile Gly Lys Thr Glu Tyr Ser 
705                 710                 715                 720 


Lys Asp Leu Val Gly Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Ser Gln Thr Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Leu Pro Gln Gln Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Gln Gly Ile Lys Asn Ala Arg Gln Arg Met Arg Lys Leu Glu 
    770                 775                 780                 


Glu Thr Ala Lys Lys Leu Gly Ser Asn Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Asp Asn Ser Gln Leu Gln Asn Asp Lys Arg Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Tyr Leu 
            820                 825                 830         


Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys Asn 
        835                 840                 845             


Asn Ser Ile Asp Asn Lys Val Leu Thr Ser Gln Gly Ala Asn Arg Gly 
    850                 855                 860                 


Lys Leu Asp Asn Val Pro Ser Glu Ala Ile Val Arg Lys Met Lys Gly 
865                 870                 875                 880 


Tyr Trp Gln Ser Leu Leu Arg Ala Gly Ala Ile Ser Lys Gln Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Gln Val Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Thr Glu Phe Asp Asp 
    930                 935                 940                 


His Asn Lys Arg Ile Arg Lys Val His Ile Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Glu Phe Gly Leu Tyr Lys Ile Arg Asp 
                965                 970                 975     


Ile Asn His Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Ala Lys Ala Ile Leu Gly Lys Tyr  Pro Gln Leu Ala Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Phe Lys Glu  Arg Gln Lys 
    1010                 1015                 1020             


Ala Thr  Gln Lys Met Leu Phe  Tyr Ser Asn Ile Leu  Lys Phe Phe 
    1025                 1030                 1035             


Lys Asp  Gln Glu Ser Leu His  Val Asn Ser Asp Gly  Glu Glu Ile 
    1040                 1045                 1050             


Trp Asn  Ala Asn Lys His Leu  Pro Ile Ile Lys Asn  Val Leu Ser 
    1055                 1060                 1065             


Ile Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1070                 1075                 1080             


Gly Phe  Tyr Lys Glu Ser Ile  Leu Ser Lys Gly Asn  Ser Asp Lys 
    1085                 1090                 1095             


Leu Ile  Pro Arg Lys Asn Asn  Trp Asp Thr Arg Lys  Tyr Gly Gly 
    1100                 1105                 1110             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Ile Ala Lys 
    1115                 1120                 1125             


Met Glu  Lys Gly Lys Ala Lys  Val Leu Lys Pro Val  Lys Glu Met 
    1130                 1135                 1140             


Val Gly  Ile Thr Ile Met Glu  Arg Thr Ala Phe Glu  Glu Asn Pro 
    1145                 1150                 1155             


Val Val  Phe Leu Glu Ala Arg  Gly Tyr Arg Glu Ile  Gln Glu His 
    1160                 1165                 1170             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1190                 1195                 1200             


Asn Glu  Leu Phe Leu Pro Val  Asp Tyr Met Thr Phe  Leu Tyr Leu 
    1205                 1210                 1215             


Ala Ala  His Tyr His Glu Leu  Thr Gly Ser Ser Glu  Asp Val Leu 
    1220                 1225                 1230             


Arg Lys  Lys Tyr Phe Val Asp  Arg His Leu His Tyr  Phe Asp Asp 
    1235                 1240                 1245             


Ile Ile  Gln Met Ile Asn Asp  Phe Ala Glu Arg His  Ile Leu Ala 
    1250                 1255                 1260             


Ser Ser  Asn Leu Glu Lys Ile  Asn His Thr Tyr His  Asn Asn Ser 
    1265                 1270                 1275             


Asp Leu  Pro Val Asn Glu Arg  Ala Glu Asn Ile Ile  Asn Val Phe 
    1280                 1285                 1290             


Thr Phe  Val Ala Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1295                 1300                 1305             


Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1310                 1315                 1320             


Asn Ala  Thr Leu Ile His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr 
    1325                 1330                 1335             


Arg Ile  Asp Leu Ser Gln Leu  Gly Glu Asn 
    1340                 1345             


<210>  81
<211>  1363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 10"

<400>  81

Met Thr Lys Leu Asn Gln Pro Tyr Gly Ile Gly Leu Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Val Val Asp Ala Asn Ser His Leu Leu Arg 
            20                  25                  30          


Leu Lys Gly Glu Thr Ala Ile Gly Ala Arg Leu Phe Arg Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Gly Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Thr Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Ala Pro His 
65                  70                  75                  80  


Ile Thr Lys Ile Asp Pro Asp Phe Phe Leu Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Asp Arg Phe Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Glu Asp Tyr Pro Ser Met Tyr 
        115                 120                 125             


His Leu Arg Leu His Leu Met Thr His Thr His Lys Ala Asp Pro Arg 
    130                 135                 140                 


Glu Ile Phe Leu Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 
                165                 170                 175     


Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 
        195                 200                 205             


Lys Leu Leu Asp Glu Gln Ala Thr Pro Ser Asp Thr Gln Lys Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 
225                 230                 235                 240 


Arg Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 
                245                 250                 255     


Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 
            260                 265                 270         


Ser Asn Trp Gln Phe Ser Met Gly Gln Leu Asp Asp Lys Trp Ser Asn 
        275                 280                 285             


Ile Glu Thr Ser Met Thr Asp Gln Gly Thr Glu Ile Phe Glu Gln Ile 
    290                 295                 300                 


Gln Glu Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Met Ser Leu Ser Gln Ala Lys Val Ala Asp Tyr Gly Gln His Lys Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 
            340                 345                 350         


Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gln Leu Leu Asn Arg 
385                 390                 395                 400 


Met Gly Gln Ala Asn Phe Met Leu Lys Gln Arg Thr Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Ile Gln Leu Gln Gln Arg Glu Leu Asp Gln Ile Ile Ala 
            420                 425                 430         


Asn Gln Ser Lys Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Ala His Arg Trp Lys Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


His Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Pro Lys Gln Gln Ala 
465                 470                 475                 480 


Glu Ser Gly Glu Asn Val Phe Ala Trp Met Val Arg Lys Asp Pro Ser 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Lys Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Ile Asn Asn Glu Cys Leu 
545                 550                 555                 560 


Gly Thr Asp Gln Lys Gln Arg Leu Ile Arg Glu Val Phe Glu Arg His 
                565                 570                 575     


Ser Ser Val Thr Ile Lys Gln Val Ala Asp Asn Leu Val Ala His Gly 
            580                 585                 590         


Asp Phe Ala Arg Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr His Gln Leu Lys Glu Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Thr Lys Leu Leu Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Thr Trp Ser Thr Val Phe Glu Asp His Thr Ile Phe Glu Thr Lys Leu 
                645                 650                 655     


Ala Glu Ile Glu Trp Leu Asp Pro Lys Lys Ile Asn Glu Leu Ser Gly 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Leu Leu Asp Gly 
        675                 680                 685             


Leu Lys Leu Gly Asn Gly His Thr Val Ile Gln Glu Leu Met Leu Ser 
    690                 695                 700                 


Asn His Asn Leu Met Gln Ile Leu Ala Asp Glu Thr Leu Lys Glu Thr 
705                 710                 715                 720 


Met Thr Glu Leu Asn Gln Asp Lys Leu Lys Thr Asp Asp Ile Glu Asp 
                725                 730                 735     


Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Phe Ile Glu Thr Ala Asp Gly Thr Gly Thr Ala 
    770                 775                 780                 


Gly Lys Arg Thr Gln Ser Arg Gln Lys Gln Ile Gln Thr Val Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala Gln Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser His Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Asn Ala Thr Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Asn Val Phe Ala Ser Thr Leu Phe Ala Gly Lys 
                885                 890                 895     


Met Lys Ala Thr Trp Arg Lys Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Met Leu Arg Pro Asp Glu Ile Asp Lys Phe 
        915                 920                 925             


Ala Lys Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Ala Ala Ala Gln Tyr Pro Asn Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Asp 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Tyr Pro Lys 
        995                 1000                 1005             


Leu Ala  Pro Phe Phe Thr Tyr  Gly Glu Phe Ala Lys  Val Asp Val 
    1010                 1015                 1020             


Lys Lys  Phe Arg Glu Phe Asn  Phe Ile Gly Ala Leu  Thr His Ala 
    1025                 1030                 1035             


Lys Lys  Asn Ile Ile Ala Lys  Asp Thr Gly Glu Ile  Val Trp Asp 
    1040                 1045                 1050             


Lys Glu  Arg Asp Ile Arg Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Tyr Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Ile Tyr Ala  Ala Lys Asp Ser Lys  Glu Arg Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Gln Gly Tyr  Pro Thr Gln 
    1100                 1105                 1110             


Val Tyr  Gly Gly Tyr Thr Gln  Glu Ser Gly Ser Tyr  Asn Ala Leu 
    1115                 1120                 1125             


Val Arg  Val Ala Glu Ala Asp  Thr Thr Ala Tyr Gln  Val Ile Lys 
    1130                 1135                 1140             


Ile Ser  Ala Gln Asn Ala Ser  Lys Ile Ala Ser Ala  Asn Leu Lys 
    1145                 1150                 1155             


Ser Arg  Glu Lys Gly Lys Gln  Leu Leu Asn Glu Ile  Val Val Lys 
    1160                 1165                 1170             


Gln Leu  Ala Lys Arg Arg Lys  Asn Trp Lys Pro Ser  Ala Asn Ser 
    1175                 1180                 1185             


Phe Lys  Ile Val Ile Pro Arg  Phe Gly Met Gly Thr  Leu Phe Gln 
    1190                 1195                 1200             


Asn Ala  Lys Tyr Gly Leu Phe  Met Val Asn Ser Asp  Thr Tyr Tyr 
    1205                 1210                 1215             


Arg Asn  Tyr Gln Glu Leu Trp  Leu Ser Arg Glu Asn  Gln Lys Leu 
    1220                 1225                 1230             


Leu Lys  Lys Leu Phe Ser Ile  Lys Tyr Glu Lys Thr  Gln Met Asn 
    1235                 1240                 1245             


His Asp  Ala Leu Gln Val Tyr  Lys Ala Ile Ile Asp  Gln Val Glu 
    1250                 1255                 1260             


Lys Phe  Phe Lys Leu Tyr Asp  Ile Asn Gln Phe Arg  Ala Lys Leu 
    1265                 1270                 1275             


Ser Asp  Ala Ile Glu Arg Phe  Glu Lys Leu Pro Ile  Asn Thr Asp 
    1280                 1285                 1290             


Gly Asn  Lys Ile Gly Lys Thr  Glu Thr Leu Arg Gln  Ile Leu Ile 
    1295                 1300                 1305             


Gly Leu  Gln Ala Asn Gly Thr  Arg Ser Asn Val Lys  Asn Leu Gly 
    1310                 1315                 1320             


Ile Lys  Thr Asp Leu Gly Leu  Leu Gln Val Gly Ser  Gly Ile Lys 
    1325                 1330                 1335             


Leu Asp  Lys Asp Thr Gln Ile  Val Tyr Gln Ser Pro  Ser Gly Leu 
    1340                 1345                 1350             


Phe Lys  Arg Arg Ile Pro Leu  Ala Asp Leu 
    1355                 1360             


