                         SEQUENCE LISTING

<110>  Fundaci Hospital Universitari Vall d'Hebron- Institut de 
       Recerca
 
<120>  Peptides for use in the topical treatment of retinal 
       neurodegenerative disesases, in particular in early stages of 
       diabetic retinopathy and other retinal diseases in which 
       neurodegeneration plays an essential role.

<130>  P2588PC00

<150>  EP13382063
<151>  2013-03-01

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  N-terminal region of a peptide able to interact with the mammal 
       glucagon-like peptide-1 receptor


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is an amino acid selected from alanine and glycine

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is an amino acid selected from valine and leucine

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  X is an amino acid selected from serine and lysine

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  X is an amino acid selected from tyrosine and glutamine

<400>  1

His Xaa Glu Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa 
1               5                   10              


<210>  2
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  3
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Liraglutide; analogue of glucagon like peptide-1 (7-37) (GLP-1 
       (7-37)).


<220>
<221>  LIPID
<222>  (20)..(20)
<223>  Lysine residue (K, Lys) comprises the lipophilic substituent N 
       epsilon-(gamma-glutamyl(N-alfa-hexadecanoyl)) attached by an 
       amide link to the amino group of the lysine side chain

<400>  3

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  4
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Exenatide; glucagon-like peptide-1 agonist; synthetic version of 
       hormone exendine-4 found in the saliva of the Gila monster.


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  X is a serine residue in which the -COOH terminal has been 
       replaced by a -NH2 group

<400>  4

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  5
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  5

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 
1               5                   10              


<210>  6
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  6
gggtctctgg ctacataagg acaac                                             25


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  7
aaggatggct gaagcgatga c                                                 21


<210>  8
<211>  44
<212>  PRT
<213>  Artificial

<220>
<223>  Lixisenatide; glucagon-like peptide-1 agonist; derived from 
       exenatide


<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  X is a lysine residue in which the -COOH terminal has been 
       replaced by a -NH2 group

<400>  8

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Xaa 
        35                  40                  


