                         SEQUENCE LISTING

<110>  Roche Diagnostics GmbH
       F. Hoffmann-La Roche AG
       Roche Diagnostics Operations Inc.
 
<120>  Agents, kits and methods for complement factor H-related protein 
       1 detection

<130>  R68468PC

<150>  EP 13 156 823.0
<151>  2013-02-26

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  1231
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1231)
<223>  human complement factor H (CFH) and isoform 2 (CFHL1)

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  V -> I

<220>
<221>  VARIANT
<222>  (78)..(78)
<223>  R -> G

<220>
<221>  VARIANT
<222>  (127)..(127)
<223>  R -> L

<220>
<221>  VARIANT
<222>  (224)..(224)
<223>  missing

<220>
<221>  VARIANT
<222>  (325)..(325)
<223>  C -> Y

<220>
<221>  VARIANT
<222>  (400)..(400)
<223>  Q -> K

<220>
<221>  VARIANT
<222>  (402)..(402)
<223>  Y -> H

<220>
<221>  VARIANT
<222>  (431)..(431)
<223>  C -> S

<220>
<221>  VARIANT
<222>  (446)..(449)
<223>  KTCS -> SFTL (in isoform 2, CFHL1)

<220>
<221>  VARIANT
<222>  (450)..(1231)
<223>  Missing in isoform 2 (CFHL1)

<220>
<221>  VARIANT
<222>  (493)..(493)
<223>  T -> R

<220>
<221>  VARIANT
<222>  (536)..(536)
<223>  C -> R

<220>
<221>  VARIANT
<222>  (551)..(551)
<223>  I -> T

<220>
<221>  VARIANT
<222>  (567)..(567)
<223>  R -> G

<220>
<221>  VARIANT
<222>  (609)..(609)
<223>  V -> I

<220>
<221>  VARIANT
<222>  (630)..(630)
<223>  C -> W

<220>
<221>  VARIANT
<222>  (673)..(673)
<223>  C -> S

<220>
<221>  VARIANT
<222>  (673)..(673)
<223>  C -> Y

<220>
<221>  VARIANT
<222>  (850)..(850)
<223>  E -> K

<220>
<221>  VARIANT
<222>  (890)..(890)
<223>  S -> I

<220>
<221>  VARIANT
<222>  (893)..(893)
<223>  H -> R

<220>
<221>  VARIANT
<222>  (915)..(915)
<223>  C -> S

<220>
<221>  VARIANT
<222>  (936)..(936)
<223>  E -> D

<220>
<221>  VARIANT
<222>  (950)..(950)
<223>  Q -> H

<220>
<221>  VARIANT
<222>  (951)..(951)
<223>  Y -> H

<220>
<221>  VARIANT
<222>  (956)..(956)
<223>  T -> M

<220>
<221>  VARIANT
<222>  (959)..(959)
<223>  C -> Y

<220>
<221>  VARIANT
<222>  (978)..(978)
<223>  W -> C

<220>
<221>  VARIANT
<222>  (997)..(997)
<223>  N -> T

<220>
<221>  VARIANT
<222>  (1007)..(1007)
<223>  V -> I

<220>
<221>  VARIANT
<222>  (1007)..(1007)
<223>  V -> L

<220>
<221>  VARIANT
<222>  (1010)..(1010)
<223>  A -> T

<220>
<221>  VARIANT
<222>  (1017)..(1017)
<223>  T -> I

<220>
<221>  VARIANT
<222>  (1021)..(1021)
<223>  Y -> F

<220>
<221>  VARIANT
<222>  (1043)..(1043)
<223>  C -> R

<220>
<221>  VARIANT
<222>  (1050)..(1050)
<223>  N -> Y

<220>
<221>  VARIANT
<222>  (1059)..(1059)
<223>  I -> T

<220>
<221>  VARIANT
<222>  (1076)..(1076)
<223>  Q -> E

<220>
<221>  VARIANT
<222>  (1078)..(1078)
<223>  R -> S

<220>
<221>  VARIANT
<222>  (1119)..(1119)
<223>  D -> G

<220>
<221>  VARIANT
<222>  (1134)..(1134)
<223>  V -> G

<220>
<221>  VARIANT
<222>  (1142)..(1142)
<223>  Y -> D

<220>
<221>  VARIANT
<222>  (1143)..(1143)
<223>  Q -> E

<220>
<221>  VARIANT
<222>  (1157)..(1157)
<223>  W -> R

<220>
<221>  VARIANT
<222>  (1163)..(1163)
<223>  C -> W

<220>
<221>  VARIANT
<222>  (1169)..(1169)
<223>  I -> L

<220>
<221>  VARIANT
<222>  (1183)..(1183)
<223>  W -> C

<220>
<221>  VARIANT
<222>  (1183)..(1183)
<223>  W -> L

<220>
<221>  VARIANT
<222>  (1183)..(1183)
<223>  W -> R

<220>
<221>  VARIANT
<222>  (1184)..(1184)
<223>  T -> R

<220>
<221>  VARIANT
<222>  (1189)..(1189)
<223>  L -> R

<220>
<221>  VARIANT
<222>  (1191)..(1191)
<223>  S -> L

<220>
<221>  VARIANT
<222>  (1194)..(1194)
<223>  G -> D

<220>
<221>  VARIANT
<222>  (1197)..(1197)
<223>  V -> A

<220>
<221>  VARIANT
<222>  (1198)..(1198)
<223>  E -> A

<220>
<221>  VARIANT
<222>  (1199)..(1199)
<223>  F -> S

<220>
<221>  VARIANT
<222>  (1210)..(1210)
<223>  R -> C

<220>
<221>  VARIANT
<222>  (1215)..(1215)
<223>  R -> G

<220>
<221>  VARIANT
<222>  (1215)..(1215)
<223>  R -> Q

<220>
<221>  VARIANT
<222>  (1225)..(1231)
<223>  YPTCAKR -> FQS

<220>
<221>  VARIANT
<222>  (1226)..(1226)
<223>  P -> S

<400>  1

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  2
<211>  330
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(330)
<223>  human complement factor H related protein 1 (CFHR1)

<220>
<221>  VARIANT
<222>  (157)..(157)
<223>  H -> Y

<220>
<221>  VARIANT
<222>  (159)..(159)
<223>  L -> V

<220>
<221>  VARIANT
<222>  (175)..(175)
<223>  E -> Q

<220>
<221>  VARIANT
<222>  (296)..(296)
<223>  A -> V

<400>  2

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser 
145                 150                 155                 160 


Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys 
                165                 170                 175     


Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
            180                 185                 190         


Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
        195                 200                 205             


Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
    210                 215                 220                 


Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
225                 230                 235                 240 


Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
                245                 250                 255     


Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
            260                 265                 270         


Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
        275                 280                 285             


Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr 
    290                 295                 300                 


Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
305                 310                 315                 320 


Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                325                 330 


<210>  3
<211>  270
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(270)
<223>  human complement factor H related protein 2 (CFHR2)

<220>
<221>  VARIANT
<222>  (144)..(171)
<223>  ISAEKCGPPPPIDNGDITSFLLSVYAPG -> S (in isoform Short)

<400>  3

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile 
    130                 135                 140                 


Ser Ala Glu Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Ser Val Tyr Ala Pro Gly Ser Ser Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Asn Gln Ile Thr Cys 
            180                 185                 190         


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu Asp Pro Cys Val 
        195                 200                 205             


Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile Lys Leu Lys Trp Thr 
    210                 215                 220                 


Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp Ile Val Glu Phe Val 
225                 230                 235                 240 


Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His Ser Phe Arg Ala Met 
                245                 250                 255     


Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys Glu Glu Lys 
            260                 265                 270 


<210>  4
<211>  330
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(330)
<223>  human complement factor H related protein 3 (CFHR3)

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  H -> Y

<400>  4

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg 
    130                 135                 140                 


Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu 
145                 150                 155                 160 


Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys 
                165                 170                 175     


Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys 
            180                 185                 190         


Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Asn Ser Ser Glu 
        195                 200                 205             


Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Pro Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr Glu 
            260                 265                 270         


Glu Asn Met Asn Lys Asn Asn Ile Lys Leu Lys Gly Arg Ser Asp Arg 
        275                 280                 285             


Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys Leu 
    290                 295                 300                 


Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala Val Cys Arg 
305                 310                 315                 320 


Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330 


<210>  5
<211>  578
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(578)
<223>  human complement factor H related protein 4A (CFHR4A)

<400>  5

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu 
            100                 105                 110         


Thr Gln Tyr Asn Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Asn Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Pro Gln Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Asp Trp Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu 
            260                 265                 270         


Phe Pro Glu Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg 
        275                 280                 285             


Pro Tyr Phe Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp 
    290                 295                 300                 


Gln Asn Phe Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys 
305                 310                 315                 320 


Thr Gln Asp Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Cys Ser 
                325                 330                 335     


Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser 
            340                 345                 350         


Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr 
        355                 360                 365             


Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn 
    370                 375                 380                 


Gly Trp Ser Ala Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val 
385                 390                 395                 400 


Phe Glu Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His 
                405                 410                 415     


Asp Thr Leu Asp Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly 
            420                 425                 430         


Asn Thr Thr Gly Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe 
        435                 440                 445             


Pro Thr Cys Tyr Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile 
    450                 455                 460                 


Ser Asn Gly Asp Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln 
465                 470                 475                 480 


Ser Arg Val Glu Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser 
                485                 490                 495     


Asn Tyr Val Thr Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys 
            500                 505                 510         


Ile His Pro Cys Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile 
        515                 520                 525             


Gln Leu Lys Gly Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp 
    530                 535                 540                 


Thr Ile Glu Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val 
545                 550                 555                 560 


Leu Ser Phe Gln Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg 
                565                 570                 575     


Cys Glu 
        


<210>  6
<211>  331
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(331)
<223>  human complement factor H related protein 4B (CFHR4B)

<220>
<221>  VARIANT
<222>  (306)..(306)
<223>  G -> E

<400>  6

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu 
            100                 105                 110         


Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr 
            260                 265                 270         


Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp 
        275                 280                 285             


Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys 
    290                 295                 300                 


Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys 
305                 310                 315                 320 


Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330     


<210>  7
<211>  569
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(569)
<223>  human complement factor H related protein 5 (CFHR5)

<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  P -> S

<220>
<221>  VARIANT
<222>  (216)..(216)
<223>  N -> S

<220>
<221>  VARIANT
<222>  (277)..(277)
<223>  Y -> N

<220>
<221>  VARIANT
<222>  (356)..(356)
<223>  R -> H

<220>
<221>  VARIANT
<222>  (379)..(379)
<223>  V -> L

<220>
<221>  VARIANT
<222>  (521)..(521)
<223>  L -> I

<220>
<221>  VARIANT
<222>  (529)..(529)
<223>  L -> R

<400>  7

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly Glu Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe 
            20                  25                  30          


Leu Tyr Asp Glu Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys 
    130                 135                 140                 


Gly Glu Cys His Val Pro Ile Leu Glu Ala Asn Val Asp Ala Gln Pro 
145                 150                 155                 160 


Lys Lys Glu Ser Tyr Lys Val Gly Asp Val Leu Lys Phe Ser Cys Arg 
                165                 170                 175     


Lys Asn Leu Ile Arg Val Gly Ser Asp Ser Val Gln Cys Tyr Gln Phe 
            180                 185                 190         


Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys 
        195                 200                 205             


Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys 
    210                 215                 220                 


Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn 
225                 230                 235                 240 


Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp 
                245                 250                 255     


Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile 
            260                 265                 270         


Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln 
        275                 280                 285             


His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile 
    290                 295                 300                 


Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro 
305                 310                 315                 320 


Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val 
                325                 330                 335     


Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn 
            340                 345                 350         


Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser 
        355                 360                 365             


Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys 
    370                 375                 380                 


Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn 
385                 390                 395                 400 


Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu 
                405                 410                 415     


Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys 
            420                 425                 430         


Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr 
        435                 440                 445             


Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro 
    450                 455                 460                 


Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser 
465                 470                 475                 480 


Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln 
                485                 490                 495     


Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu 
            500                 505                 510         


Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys 
        515                 520                 525             


Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro 
    530                 535                 540                 


His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu 
545                 550                 555                 560 


Gly Lys Phe Glu Tyr Pro Ile Cys Glu 
                565                 


<210>  8
<211>  158
<212>  PRT
<213>  Mus musculus

<400>  8

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ala 
    130                 135                 140                 


Ala Ala Gly Gly Gly Ser His His His His His His His His 
145                 150                 155             


<210>  9
<211>  330
<212>  PRT
<213>  Mus musculus

<400>  9

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser 
145                 150                 155                 160 


Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys 
                165                 170                 175     


Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
            180                 185                 190         


Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
        195                 200                 205             


Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
    210                 215                 220                 


Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
225                 230                 235                 240 


Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
                245                 250                 255     


Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
            260                 265                 270         


Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
        275                 280                 285             


Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr 
    290                 295                 300                 


Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
305                 310                 315                 320 


Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                325                 330 


<210>  10
<211>  304
<212>  PRT
<213>  Mus musculus

<400>  10

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile 
    130                 135                 140                 


Ser Ala Glu Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Ser Val Tyr Ala Pro Gly Ser Ser Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Asn Gln Ile Thr Cys 
            180                 185                 190         


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu Asp Pro Cys Val 
        195                 200                 205             


Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile Lys Leu Lys Trp Thr 
    210                 215                 220                 


Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp Ile Val Glu Phe Val 
225                 230                 235                 240 


Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His Ser Phe Arg Ala Met 
                245                 250                 255     


Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys Glu Glu Lys Ala Ala 
            260                 265                 270         


Ala Gly Gly Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile 
        275                 280                 285             


Glu Trp His Glu Gly Gly Gly Ser His His His His His His His His 
    290                 295                 300                 


<210>  11
<211>  364
<212>  PRT
<213>  Mus musculus

<400>  11

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg 
    130                 135                 140                 


Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu 
145                 150                 155                 160 


Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys 
                165                 170                 175     


Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys 
            180                 185                 190         


Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Asn Ser Ser Glu 
        195                 200                 205             


Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Pro Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr Glu 
            260                 265                 270         


Glu Asn Met Asn Lys Asn Asn Ile Lys Leu Lys Gly Arg Ser Asp Arg 
        275                 280                 285             


Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys Leu 
    290                 295                 300                 


Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala Val Cys Arg 
305                 310                 315                 320 


Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu Ala Ala Ala Gly Gly Gly 
                325                 330                 335     


Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
            340                 345                 350         


Gly Gly Gly Ser His His His His His His His His 
        355                 360                 


<210>  12
<211>  365
<212>  PRT
<213>  Mus musculus

<400>  12

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Leu Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu 
            100                 105                 110         


Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Glu Trp Ser Glu Pro Pro Gly Cys Ile His Pro Cys Ile Ile Thr 
            260                 265                 270         


Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp 
        275                 280                 285             


Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys 
    290                 295                 300                 


Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys 
305                 310                 315                 320 


Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu Ala Ala Ala Gly Gly 
                325                 330                 335     


Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
            340                 345                 350         


Glu Gly Gly Gly Ser His His His His His His His His 
        355                 360                 365 


<210>  13
<211>  603
<212>  PRT
<213>  Mus musculus

<400>  13

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly Glu Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe 
            20                  25                  30          


Leu Tyr Asp Glu Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys 
    130                 135                 140                 


Gly Glu Cys His Val Pro Ile Leu Glu Ala Asn Val Asp Ala Gln Pro 
145                 150                 155                 160 


Lys Lys Glu Ser Tyr Lys Val Gly Asp Val Leu Lys Phe Ser Cys Arg 
                165                 170                 175     


Lys Asn Leu Ile Arg Val Gly Ser Asp Ser Val Gln Cys Tyr Gln Phe 
            180                 185                 190         


Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys 
        195                 200                 205             


Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys 
    210                 215                 220                 


Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn 
225                 230                 235                 240 


Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp 
                245                 250                 255     


Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile 
            260                 265                 270         


Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln 
        275                 280                 285             


His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile 
    290                 295                 300                 


Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro 
305                 310                 315                 320 


Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val 
                325                 330                 335     


Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn 
            340                 345                 350         


Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser 
        355                 360                 365             


Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys 
    370                 375                 380                 


Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn 
385                 390                 395                 400 


Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu 
                405                 410                 415     


Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys 
            420                 425                 430         


Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr 
        435                 440                 445             


Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro 
    450                 455                 460                 


Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser 
465                 470                 475                 480 


Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln 
                485                 490                 495     


Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu 
            500                 505                 510         


Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys 
        515                 520                 525             


Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro 
    530                 535                 540                 


His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu 
545                 550                 555                 560 


Gly Lys Phe Glu Tyr Pro Ile Cys Glu Ala Ala Ala Gly Gly Gly Ser 
                565                 570                 575     


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly 
            580                 585                 590         


Gly Gly Ser His His His His His His His His 
        595                 600             


<210>  14
<211>  483
<212>  PRT
<213>  Mus musculus

<400>  14

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu Ala Ala Ala Gly Gly Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala 
    450                 455                 460                 


Gln Lys Ile Glu Trp His Glu Gly Gly Gly Ser His His His His His 
465                 470                 475                 480 


His His His 
            


<210>  15
<211>  772
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(772)
<223>  cDNA Heavy Chain<CFHR1>M-5.1.5

<400>  15
tttttttttt tttgctctga cagaggaggc cggtcctgga ttcgattccc agttcctcac       60

attcagtcag cactgaacac ggacccctca ccatgaactt cgggctcagc ttgattttcc      120

ttgccctcat tttaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggagact      180

tagtgaagcc tggagggtcc ctgaaactct cctgtgcagc ctctggattc actttcagta      240

gctatgacat gtcttgggtt cgccagactc cagacaagag gctggagtgg gtcgcaacca      300

ttagtagtgg tggtagtaac acctactatc cagacagtgt gaaggggcga ttcaccatct      360

ccagagacaa tgccaagaac accctgtacc tgcaaatgag cagtctgaag tctgaggaca      420

cagccatgta ttactgtgca agacaagggt attactacgg tagtagttac tatgctatgg      480

actactgggg tcaaggaacc tcagtcaccg tctcctcagc caaaacgaca cccccatctg      540

tctatccact ggcccctgga tctgctgccc aaactaactc catggtgacc ctgggatgcc      600

tggtcaaggg ctatttccct gagccagtga cagtgacctg gaactctgga tccctgtcca      660

gcggtgtgca caccttccca gctgtcctgc agtctgacct ctacactctg agcagctcag      720

tgactgtccc ctccagcacc tggcccagcg agaccgtcac ctgcaacgtt gc              772


<210>  16
<211>  227
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(227)
<223>  Heavy Chain <CFHR1>M-5.1.5

<400>  16

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Asn Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Gly Tyr Tyr Tyr Gly Ser Ser Tyr Tyr Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys 
    130                 135                 140                 


Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln 
145                 150                 155                 160 


Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser 
        195                 200                 205             


Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys 
    210                 215                 220                 


Asn Val Ala 
225         


<210>  17
<211>  712
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(712)
<223>  cDNA coding for Light Chain <CFHR1>M-5.1.5

<400>  17
ggaccaaaat tcaaagacaa aatggattct caagtgcaga ttttcagctt ccttctaatc       60

agtgccttag tcataatgtc cagaggacag attgttctca cccagtctcc agcaatcatg      120

tctgcatctc caggggagaa ggtcaccatg acctgcaggg ccagttcaag tgtaagttcc      180

agttacttgc actggtacca gcagaagcca ggatcttccc ccaaactctg gatttatatc      240

acatccagcc tggcttcagg agtcccagct cgcttcagtg gcagtgggtc tgggacctct      300

tactctctca caatcagcag tgtggaggct gaggatggtg ccacttatta ctgccagcag      360

tatcatagtt ccccgtatac gttcggatcg gggaccaagc tggaaataaa acgggctgat      420

gctgcaccaa ctgtatccat cttcccacca tccagtgagc agttaacatc tggaggtgcc      480

tcagtcgtgt gcttcttgaa caacttctac cccaaagaca tcaatgtcaa gtggaagatt      540

gatggcagtg aacgacaaaa tggcgtcctg aacagttgga ctgatcagga cagcaaagac      600

agcacctaca gcatgagcag caccctcacg ttgaccaagg acgagtatga acgacataac      660

agctatacct gtgaggccac tcacaagaca tcaacttcac ccattgtcaa ga              712


<210>  18
<211>  231
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(231)
<223>  Light Chain <CFHR1>M-5.1.5

<400>  18

Met Asp Ser Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Leu 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Ser Ser Pro Lys Leu Trp Ile Tyr Ile Thr Ser Ser Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Val Glu Ala Glu Asp Gly Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Tyr His Ser Ser Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser 
                165                 170                 175     


Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu 
        195                 200                 205             


Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser 
    210                 215                 220                 


Thr Ser Pro Ile Val Lys Xaa 
225                 230     


<210>  19
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  hCDR1 of 5.1.5

<400>  19

Gly Phe Thr Phe Ser Ser Tyr Asp 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  hCDR2 of 5.1.5

<400>  20

Ile Ser Ser Gly Gly Ser Asn Thr 
1               5               


<210>  21
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  hCDR3 of 5.1.5

<400>  21

Ala Arg Gln Gly Tyr Tyr Tyr Gly Ser Ser Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210>  22
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  LCDR1 of 5.1.5

<400>  22

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  LCDR3 of 5.1.5

<400>  23

Gln Gln Tyr His Ser Ser Pro Tyr Thr 
1               5                   


<210>  24
<211>  631
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(631)
<223>  cDNA of the heavy chain of Mab 4.1.3

<400>  24
gaccacgcgt atcgatgtcg actttttttt ttttttttnc atcgctctca ctggaggctg       60

atctctgaag ataaggaggt gtagcctaaa agatgagagt gctggttctt ttgtggctgt      120

tcacagcctt tcctggtatc ctgtctgatg tgcagcttca ggagtcggga cctggcctgg      180

tgaaaccttc tcagtctctg tccctcacct gcactgtcac tggctactca atcaccagtg      240

aatatgcctg gaactggatc cggcaatttc caggaaacaa actggagtgg atggcctaca      300

taaattccag tggtaaatct agctataatc catctctcaa aagtcgaatc tctgtcactc      360

gagacacatc caagaaccag ttcttcctgc aattgaattc tgtgactact gaggacacag      420

ccacatatta ctgtgcgaga gagggatatg gtaactaccc ggcctggttt gcttactggg      480

gccaagggac tctggtcact gtctctgcag ccaaaacaac agccccatcg gtctatccac      540

tggcccctgt gtgtggagat acaactggct cctcggtgac tctaggatgc ctggtcaagg      600

gttatttccc tgagccagtg accttgacct g                                     631


<210>  25
<211>  179
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(179)
<223>  heavy chain of Mab 4.1.3

<400>  25

Met Arg Val Leu Val Leu Leu Trp Leu Phe Thr Ala Phe Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Glu Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Ala Tyr Ile Asn Ser Ser Gly Lys Ser Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Val Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Gly Tyr Gly Asn Tyr Pro Ala Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
145                 150                 155                 160 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Leu Thr 
            


<210>  26
<211>  749
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(749)
<223>  cDNA sequence of the light chain of Mab 4.1.3

<400>  26
gaccacgagc acgcgtgtcg actttttttt ttttttttgt awttgaagtc aagactcagc       60

ctggacatga tgtcctctgc tcagttcctt ggtctcctgt tgctctgttt tcaaggtacc      120

agatgtgata tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga      180

gtcaccatca gttgcagtgc aagtcaggac attaacaatt atttaaactg gtatcagcag      240

aaaccagatg gaactgttaa actcctgatt tattacactt caaatttaca ctcaggagtc      300

ccatcaaggt tcagtggcag tgggtctggg acagattatt ctctcaccat cagcaacctg      360

gaacctgaag atattgccac ttacttttgt cagcagtata gtaagcttcc tcggacgttc      420

ggtggaggca ccaagctgga aatcaaacgg gctgatgctg caccaactgt atccatcttc      480

ccaccatcca gtgagcagtt aacatctgga ggtgcctcag tcgtgtgctt cttgaacaac      540

ttctacccca aagacatcaa tgtcaagtgg aagattgatg gcagtgaacg acaaaatggc      600

gtcctgaaca gttggactga tcaggacagc aaagacagca cctacagcat gagcagcacc      660

ctcacgttga ccaaggacga gtatgaacga cataacagct atacctgtga ggccactcac      720

aagacatcaa ctttcaccca ttgtcaaga                                        749


<210>  27
<211>  227
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(227)
<223>  Light chain of Mab 4.1.3

<400>  27

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Lys Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Phe Thr 
    210                 215                 220                 


His Cys Gln 
225         


<210>  28
<211>  599
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(599)
<223>  cDNA sequence of the heavy chain of Mab 4.2.53

<400>  28
gaccacgcgt atcgatgtcg actttttttt ttttttttat ctcctcacta gagcccccat       60

cagagcatgg ctgtcctggt gctgttcctc tgcctggttg catttccaag ctgtgtcctg      120

tcccaggtgc agttgaagga gtcaggacct ggcctggtgg cgccctcaca gagcctgtcc      180

atcacttgca ctgtctctgg gttttcatta accagttatg gtgtacactg ggttcgccag      240

cctccaggaa agggtctgga gtggctggga gtaatatggg ctggtggaaa tacagattat      300

atttcggctc tcatgtccag actgagcatc agcaaagaca actccaagag ccaagttttc      360

ttaaaaataa acagactgca aactgatgac acagccgtgt actactgtgc cagagatcat      420

tatgatggtt actacatgga gtactggggt caaggaacct cagtcaccgt ctccccagcc      480

aaaacgacac ccccatctgt ctatccactg gcccctggat ctgctgccca aactaactcc      540

atggtgaccc tgggatgcct ggtcaagggc tatttccctg agccagtgac agtgacctg       599


<210>  29
<211>  177
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(177)
<223>  heavy chain of Mab 4.2.53

<400>  29

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Asn Thr Asp Tyr Ile Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Ile Asn Arg Leu Gln Thr Asp Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp His Tyr Asp Gly Tyr Tyr Met Glu Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Pro Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Thr 
    


<210>  30
<211>  748
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(748)
<223>  cDNA sequence of the light chain of Mab 4.2.53

<400>  30
gaccacgcgt atcgatgtcg actttttttt ttttttttag tcattcttgg tcaggagacg       60

ttgtagaaat gagaccgtct attcagttcc tggggctctt gttgttctgg cttcatggtg      120

ttcagtgtga catccagatg acacagtctc catcctcact gtctgcatct ctgggaggca      180

aagtcaccat cacttgcaag gcaagccagg acattaacaa atatttagct tggtaccaac      240

acaagcctgg aaaaggtcct agactgctca tacattacac atttacatta cagccaggca      300

tcccatcaag gttcagtgga ggtgggtctg ggagagatta ttccttcaac atcaacaacc      360

tggagcctga ggatattgca acttattatt gtctgcagta tgataatctg tatacgttcg      420

ggggggggac caagctggaa ataaaacggg ctgatgctgc accaactgta tccatcttcc      480

caccatccag tgagcagtta acatctggag gtgcctcagt cgtgtgcttc ttgaacaact      540

tctaccccaa agacatcaat gtcaagtgga agattgatgg cagtgaacga caaaatggcg      600

tcctgaacag ttggactgat caggacagca aagacagcac ctacagcatg agcagcaccc      660

tcacgttgac caaggacgag tatgaacgac ataacagcta tacctgtgag gccactcaca      720

agacatcaac tttcacccat tgtcaaga                                         748


<210>  31
<211>  226
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(226)
<223>  Light chain of Mab 4.2.53

<400>  31

Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Lys Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Tyr Thr Phe Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Gly Gly Ser Gly Arg Asp Tyr Ser Phe Asn Ile Asn 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Phe Thr His 
    210                 215                 220                 


Cys Gln 
225     


<210>  32
<211>  649
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(649)
<223>  cDNA sequence of the heavy chain of Mab 4.2.74

<400>  32
gaccacgcgt atcgatgtcg actttttttt ttttttttwg ctctgacaga ggagccaagc       60

cctggattcc caggtcctca cattcagtga tcagcactga acacagacca ctcaccatgg      120

actccaggct caatttagtt ttccttgtcc ttattttaaa aggtgtccag tgtgatgtgc      180

ggctggtgga gtctggggga ggcttagtgc agcctggagg gtcccggaaa ctctcctgtg      240

cagcctctgg attcactttc agtagctttg gaatgcactg ggttcgtcag gctccagaga      300

aggggctgga gtgggtcgca tacattagta gtggcagtag taccatctac tatgcagaca      360

cagtgaaggg ccgattcacc atctccagag acaatcccaa gaacaccctg ttcctgcaaa      420

tgaccagtct aaggtctgag gacacggcca tgtattactg tgcaagatgg ggtaactcgt      480

atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctcagcc aaaacgacac      540

ccccatctgt ctatccactg gcccctggat ctgctgccca aactaactcc atggtgaccc      600

tgggatgcct ggtcaagggc tatttccctg agccagtgac agtgacctg                  649


<210>  33
<211>  177
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(177)
<223>  heavy chain of Mab 4.2.74

<400>  33

Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly Asn Ser Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Thr 
    


<210>  34
<211>  744
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(744)
<223>  cDNA sequence of the light chain of Mab 4.2.74

<400>  34
tttttttttt ttttttctac atctgaaagg caggtggagc aagatggaat cacagactca       60

ggtcctcatg tccctgctgt tctgggtatc tggtacctgt ggggacattg tgatgacaca      120

gtctccatcc tccctgactg tgacagcagg agagaaggtc actatgagct gcaagtccag      180

tcagagtctg ctaaacagag gaaatcaaaa gaactatttg acctggtacc agcagaaacc      240

agggcagcct cctaaactgt tgatttactg ggcatccact agggaatctg gggtccctga      300

tcgcttcaca ggcagtggat ctggaacaga tttcactctc accatcagca gtgtgctggc      360

tgaagacctg gcagtttatt actgtcagat tgcttatagt tctccattca cgttcggctc      420

ggggacaaag ttggaaatta aacgggctga tgctgcacca actgtatcca tcttcccacc      480

atccagtgag cagttaacat ctggaggtgc ctcagtcgtg tgcttcttga acaacttcta      540

ccccaaagac atcaatgtca agtggaagat tgatggcagt gaacgacaaa atggcgtcct      600

gaacagttgg actgatcagg acagcaaaga cagcacctac agcatgagca gcaccctcac      660

gttgaccaag gacgagtatg aacgacataa cagctatacc tgtgaggcca ctcacaagac      720

atcaactttc acccattgtc aaga                                             744


<210>  35
<211>  233
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(233)
<223>  light chain of Mab 4.2.74

<400>  35

Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr 
            20                  25                  30          


Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Arg Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Leu Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Ile Ala Tyr Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Phe Thr His Cys Gln 
225                 230             


<210>  36
<211>  653
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(653)
<223>  cDNA sequence of the heavy chain of Mab 5.3.23

<400>  36
gaccacgcgt atcgatgtcg actttttttt ttttttttwg acagacgcac aaccctggac       60

tcccaagtct ttctcttcag tgacaaacac agacatagaa cattcaccat gtacttggga      120

ctgaacagtg taatcatagt ctttctctta aaaggtgtcc agagtgaagt gaagcttgag      180

gagtctggag gaggcttggt gcaacctgga ggatccatga aactctcttg tgatggttct      240

ggattcactt ttagtgatgc ctggatgggc tgggtccgcc agtcaccaga gaaggggctt      300

gaatgggttt ctgaaattag aaacagagct aataatcatg agacacatta tgctgagtct      360

gtgaaaggga ggttcaccat ctcaagagat gattccaaaa gtagagtgta cttgcaaatg      420

aacagtttaa gagctgaaga cactggcatt tattactgta acgggcggta ttatgattcc      480

tactggttcc tcgatgtctg gggcgcaggg accacggtca ccgtctcctc agccaaaacg      540

acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg      600

accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac ctg             653


<210>  37
<211>  181
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(181)
<223>  heavy chain of Mab 5.3.23

<400>  37

Met Tyr Leu Gly Leu Asn Ser Val Ile Ile Val Phe Leu Leu Lys Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Asp Gly Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Gly Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Glu Ile Arg Asn Arg Ala Asn Asn His Glu Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Arg Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Asn Gly Arg Tyr Tyr Asp Ser Tyr Trp Phe Leu 
        115                 120                 125             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
145                 150                 155                 160 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Thr 
            180     


<210>  38
<211>  729
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(729)
<223>  cDNA sequence of the light chain of Mab 5.3.23

<400>  38
tttttttttt tttttttttg aaatacatca ggcaggcaaa ggcatcaaga tgaagtcaca       60

gacccaggtc ttcatatttc tactgctctg tgtgtctggt actcatggga atattgtgat      120

gacccagact cccaaattcc tgcctgtgtc agtaggagac agggttacca tgacctgcaa      180

ggccagtcag agtgtgggtt ataatgtggc ctggttccaa cagaagccag gacagtctcc      240

taaactgctg atatactatg catccaatcg ctacactgga gtccctgatc gcttcactgg      300

cagtggaggt gggacagatt tcactttcac catcagcagt gtgcaggttg aagacctggc      360

agtttatttc tgtcagcagc attatatctc tccaacgttc ggatcgggga ccaagcttga      420

aataaaacgg gctgatgctg caccaactgt atccatcttc ccaccatcca gtgagcagtt      480

aacatctgga ggtgcctcag tcgtgtgctt cttgaacaac ttctacccca aagacatcaa      540

tgtcaagtgg aagattgatg gcagtgaacg acaaaatggc gtcctgaaca gttggactga      600

tcaggacagc aaagacagca cctacagcat gagcagcacc ctcacgttga ccaaggacga      660

gtatgaacga cataacagct atacctgtga ggccactcac aagacatcaa ctttcaccca      720

ttgtcaaga                                                              729


<210>  39
<211>  226
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  light chain of Mab 5.3.23

<400>  39

Met Lys Ser Gln Thr Gln Val Phe Ile Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      


Gly Thr His Gly Asn Ile Val Met Thr Gln Thr Pro Lys Phe Leu Pro 
            20                  25                  30          


Val Ser Val Gly Asp Arg Val Thr Met Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Tyr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Gly Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Val Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Tyr 
            100                 105                 110         


Ile Ser Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Phe Thr His 
    210                 215                 220                 


Cys Gln 
225     


<210>  40
<211>  616
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(616)
<223>  cDNA sequence of the heavy chain of Mab L20/3

<400>  40
gaccacgcgt atcgatgtcg actttttttt ttttttttwa catatgtcca atgtcctctc       60

cacaggcact gaacacactg actctaacca tgggatggag ctggatcttt ctcttcttcc      120

tgtcaggaac tgcaggtgtc ctctctgagg tcctgctgca acagtctgga cctgaactag      180

tgaagcctgg ggcttcagtg aagataccct gcaaggcctc tggatacaca ttcactgact      240

acaacatgga ctgggtgaag cagagccatg gaaagagcct tgaatggatt ggagacatta      300

atcctaacaa tggttttact atctacaacc agaagttcaa gggcaaggcc acattgactg      360

tagacaagtc ctccagcaca gcctacatgg agctccgcag cctgacatct gaggacactg      420

caatctatta ctgtgcaatc aactgggact ggtttgctta ctggggccaa gggactctgg      480

tcactgtctc tgcagccaaa acgacacccc catctgtcta tccactggcc cctggatctg      540

ctgcccaaac taactccatg gtgaccctgg gatgcctggt caagggctat ttccctgagc      600

cagtgacagt gacctg                                                      616


<210>  41
<211>  175
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(175)
<223>  heavy chain of Mab L20/3

<400>  41

Met Gly Trp Ser Trp Ile Phe Leu Phe Phe Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Leu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Asn Pro Asn Asn Gly Phe Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Ile Asn Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175 


<210>  42
<211>  778
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(778)
<223>  cDNA sequence of the light chain of Mab L20/3

<400>  42
gaccacgcgt agcgatgtcg actttttttt ttttttttac tgatcagtct cctcaggctg       60

tctcctcagg ttgcctcctc aaaatgaagt tgcctgttag gctgttggtg ctgatgttct      120

ggattcctgc ttccagcagt gatgttttga tgacccaaac tccactctcc ctgcctgtca      180

gtcttggaga tcaagcctcc atctcttgca gatctagtca gagcattgta cataataatg      240

gaaacaccta tttagaatgg tacctgctga aaccaggcca gtctccaaag ctcctgatct      300

acaaagtttc caaccgattt tctggggtcc cagacaggtt cagtggcagt ggatcaggga      360

cagatttcac actcaagatc agcagagtgg aggctgagga tctgggagtt tattactgct      420

ttcaaggttc acatgttccg tacacgttcg gaggggggac caagctggaa ataaaacggg      480

ctgatgctgc accaactgta tccatcttcc caccatccag tgagcagtta acatctggag      540

gtgcctcagt cgtgtgcttc ttgaacaact tctaccccaa agacatcaat gtcaagtgga      600

agattgatgg cagtgaacga caaaatggcg tcctgaacag ttggactgat caggacagca      660

aagacagcac ctacagcatg agcagcaccc tcacgttgac caaggacgag tatgaacgac      720

ataacagcta tacctgtgag gccactcaca agacatcaac tttcacccat tgtcaaga        778


<210>  43
<211>  231
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(231)
<223>  light chain of Mab L20/3

<400>  43

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val His Asn Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Leu Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Phe Thr His Cys Gln 
225                 230     


