                               SEQUENCE LISTING

<110> NOVARTIS AG
      TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
 
<120> EFFECTIVE TARGETING OF PRIMARY HUMAN LEUKEMIA USING ANTI-CD123 
      CHIMERIC ANTIGEN RECEPTOR ENGINEERED T CELLS

<130> N2067-7001WO

<140>
<141>

<150> 61/865,856
<151> 2013-08-14

<150> 61/767,058
<151> 2013-02-20

<160> 136   

<170> PatentIn version 3.5

<210> 1
<211> 494
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn 
65                  70                  75                  80  


Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
            180                 185                 190         


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
        195                 200                 205             


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
    210                 215                 220                 


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ser Gly Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210> 2
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Ile 
        115                 120                 125             


Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met 
145                 150                 155                 160 


Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met Gly Trp 
                165                 170                 175     


Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly 
            180                 185                 190         


Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu His 
        195                 200                 205             


Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
    210                 215                 220                 


Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210> 3
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 4
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 5
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210> 6
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 7
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 8
<211> 1482
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acatcgtgct gacacagagc cctgcttccc tggccgtgtc cctgggacag      120

agagccacaa tcagctgcag ggccagcgag agcgtggaca actacggcaa caccttcatg      180

cactggtatc agcagaagcc cggccagccc cccaagctgc tgatctacag agccagcaac      240

ctggaaagcg gcatccccgc cagattttcc ggcagcggca gcagaaccga cttcaccctg      300

accatcaacc ccgtggaagc cgacgacgtg gccacctact actgccagca gagcaacgag      360

gaccccccca catttggagc cggcaccaag ctggaactga agggcggagg cggatctggc      420

ggcggaggat cttctggggg aggctctcag attcagctgg tgcagagcgg cccagagctg      480

aagaaacccg gcgagacagt gaagatctcc tgcaaggcct ccggctacat cttcaccaat      540

tacggcatga actgggtcaa gcaggcccct ggcaagagct tcaagtggat gggctggatc      600

aacacctaca ccggcgagag cacctacagc gccgacttca agggcagatt cgccttcagc      660

ctggaaacca gcgccagcac cgcctacctg cacatcaacg acctgaagaa cgaggacacc      720

gccacctatt tctgcgccag aagcggcggc tacgacccca tggattattg gggccagggc      780

accagcgtga ccgtgtcctc tgctagctcc ggaaccacga cgccagcgcc gcgaccacca      840

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      900

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg      960

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     1020

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1080

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1140

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac     1200

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1260

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1320

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1380

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1440

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                        1482


<210> 9
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 9
gacatcgtgc tgacacagag ccctgcttcc ctggccgtgt ccctgggaca gagagccaca       60

atcagctgca gggccagcga gagcgtggac aactacggca acaccttcat gcactggtat      120

cagcagaagc ccggccagcc ccccaagctg ctgatctaca gagccagcaa cctggaaagc      180

ggcatccccg ccagattttc cggcagcggc agcagaaccg acttcaccct gaccatcaac      240

cccgtggaag ccgacgacgt ggccacctac tactgccagc agagcaacga ggaccccccc      300

acatttggag ccggcaccaa gctggaactg aagggcggag gcggatctgg cggcggagga      360

tcttctgggg gaggctctca gattcagctg gtgcagagcg gcccagagct gaagaaaccc      420

ggcgagacag tgaagatctc ctgcaaggcc tccggctaca tcttcaccaa ttacggcatg      480

aactgggtca agcaggcccc tggcaagagc ttcaagtgga tgggctggat caacacctac      540

accggcgaga gcacctacag cgccgacttc aagggcagat tcgccttcag cctggaaacc      600

agcgccagca ccgcctacct gcacatcaac gacctgaaga acgaggacac cgccacctat      660

ttctgcgcca gaagcggcgg ctacgacccc atggattatt ggggccaggg caccagcgtg      720

accgtgtcct ct                                                          732


<210> 10
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

ccc                                                                     63


<210> 11
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210> 12
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210> 13
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 13
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210> 14
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 14
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210> 15
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Asn Tyr Gly Met Asn 
1               5   


<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
1               5                   


<210> 19
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
1               5                   10                  15  


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Gln Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210> 23
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Gly Tyr Ile Phe Thr Asn Tyr 
1               5           


<210> 25
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Asn Thr Tyr Thr Gly Glu 
1               5       


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
1               5                   


<210> 27
<211> 123
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 27
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210> 28
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe 
1               5                   10      


<210> 29
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Arg Ala Ser 
1           


<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Ser Asn Glu Asp Pro Pro 
1               5       


<210> 31
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210> 32
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210> 33
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Arg Val Thr Ile Thr Leu Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 34
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 
65                  70                  75                  80  


Ile Asn Ala Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Gly Gly Gly Gly Ser 
1               5   


<210> 36
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
145                 150                 155                 160 


Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser 
            180                 185                 190         


Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser 
        195                 200                 205             


Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 


<210> 37
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 37
gacatcgtgc tgacccaatc cccggacagc ctcgcagtct cactcggaga acgcgccact       60

atcaattgta gggcgtcgga gtccgtggac aattacggaa acaccttcat gcactggtac      120

caacaaaaac ctggtcagcc acctaagctg ctgatctacc gcgcctcgaa tctggaatca      180

ggagtgccgg acagattctc ggggtccggc tcccggacgg atttcacttt gaccatctcg      240

tcacttcaag ctgaggacgt cgcggtgtac tactgccagc agagcaacga agatccaccc      300

acgttcggac aaggcaccaa gctggagatt aaaggaggcg gaggctccgg tggaggagga      360

tcgggaggag gcggctccgg cggaggtgga tcgcagattc agctggtgca gtcgggttca      420

gaattgaaga aaccaggagc ctcggtgaag gtcagctgca aggcatcagg gtacatcttc      480

actaactacg gcatgaactg ggtgcgccag gctccgggac aggggctgga gtggatggga      540

tggatcaaca cttacaccgg ggagtcaact tactcggctg actttaaggg ccggtttgtg      600

ttctccctcg acactagcgt gagcaccgcc tatcttcaaa tcaacgccct caaggcggaa      660

gataccgccg tctactactg cgcaagatcc ggtgggtacg atccgatgga ttattgggga      720

cagggaacca ctgtcaccgt gagcagc                                          747


<210> 38
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 38
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgacatcg tgctgaccca atccccggac agcctcgcag tctcactcgg agaacgcgcc      120

actatcaatt gtagggcgtc ggagtccgtg gacaattacg gaaacacctt catgcactgg      180

taccaacaaa aacctggtca gccacctaag ctgctgatct accgcgcctc gaatctggaa      240

tcaggagtgc cggacagatt ctcggggtcc ggctcccgga cggatttcac tttgaccatc      300

tcgtcacttc aagctgagga cgtcgcggtg tactactgcc agcagagcaa cgaagatcca      360

cccacgttcg gacaaggcac caagctggag attaaaggag gcggaggctc cggtggagga      420

ggatcgggag gaggcggctc cggcggaggt ggatcgcaga ttcagctggt gcagtcgggt      480

tcagaattga agaaaccagg agcctcggtg aaggtcagct gcaaggcatc agggtacatc      540

ttcactaact acggcatgaa ctgggtgcgc caggctccgg gacaggggct ggagtggatg      600

ggatggatca acacttacac cggggagtca acttactcgg ctgactttaa gggccggttt      660

gtgttctccc tcgacactag cgtgagcacc gcctatcttc aaatcaacgc cctcaaggcg      720

gaagataccg ccgtctacta ctgcgcaaga tccggtgggt acgatccgat ggattattgg      780

ggacagggaa ccactgtcac cgtgagcagc ggctcgcacc accatcacca tcatcatcac      840

cac                                                                    843


<210> 39
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                165                 170                 175     


Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly 
        195                 200                 205             


Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu 
    210                 215                 220                 


Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ser 
            260                 265                 270         


His His His His His His His His His 
        275                 280     


<210> 40
<211> 1479
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 40
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgacatcg tgctgaccca atccccggac agcctcgcag tctcactcgg agaacgcgcc      120

actatcaatt gtagggcgtc ggagtccgtg gacaattacg gaaacacctt catgcactgg      180

taccaacaaa aacctggtca gccacctaag ctgctgatct accgcgcctc gaatctggaa      240

tcaggagtgc cggacagatt ctcggggtcc ggctcccgga cggatttcac tttgaccatc      300

tcgtcacttc aagctgagga cgtcgcggtg tactactgcc agcagagcaa cgaagatcca      360

cccacgttcg gacaaggcac caagctggag attaaaggag gcggaggctc cggtggagga      420

ggatcgggag gaggcggctc cggcggaggt ggatcgcaga ttcagctggt gcagtcgggt      480

tcagaattga agaaaccagg agcctcggtg aaggtcagct gcaaggcatc agggtacatc      540

ttcactaact acggcatgaa ctgggtgcgc caggctccgg gacaggggct ggagtggatg      600

ggatggatca acacttacac cggggagtca acttactcgg ctgactttaa gggccggttt      660

gtgttctccc tcgacactag cgtgagcacc gcctatcttc aaatcaacgc cctcaaggcg      720

gaagataccg ccgtctacta ctgcgcaaga tccggtgggt acgatccgat ggattattgg      780

ggacagggaa ccactgtcac cgtgagcagc accactaccc cagcaccgag gccacccacc      840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca      900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc      960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag     1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact     1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa     1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct acaagcaggg gcagaaccag     1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga     1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac     1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa     1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac     1440

acctatgacg ctcttcacat gcaggccctg ccgcctcgg                            1479


<210> 41
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                165                 170                 175     


Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly 
        195                 200                 205             


Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu 
    210                 215                 220                 


Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210> 42
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
145                 150                 155                 160 


Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
                165                 170                 175     


Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser 
            180                 185                 190         


Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu Asp Thr Ser Ala Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 


<210> 43
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 43
gatattgtcc tcactcaatc gccggactca ctggcggtgt ccctcggaga gagggcgacg       60

atcaattgcc gggcttccga atccgtcgat aactacggaa acacctttat gcactggtac      120

caacagaagc caggacagcc accaaagctg ttgatctacc gcgcttcaaa ccttgagtcg      180

ggtgtgccgg accgcttcag cggcagcggt tccagaaccg actttaccct caccatcagc      240

tcgctgcagg ccgaagatgt cgccgtctat tactgccaac agagcaacga agatccgcct      300

actttcggac aggggactaa actggaaatc aagggcggag gaggctcggg tggaggagga      360

tcgggaggag gcgggtccgg tggtggcgga tcgcaaatcc agctggtgca gtccggcgca      420

gaagtgaaga agccgggagc gtccgtgaaa gtgagctgca aggcctcagg gtacatcttc      480

accaattacg gcatgaattg ggtgcggcag gcacccggac agcgcctgga gtggatgggc      540

tggatcaaca cttacaccgg ggaaagcacg tactcggccg acttcaaagg acgggtgacc      600

attaccctgg atacctcggc ctcaaccgct tacatggagc tctcatcact tagatccgag      660

gacactgccg tctactactg tgcaaggagc ggaggctacg accctatgga ctattgggga      720

caaggcacta ctgtgactgt gtcgtcc                                          747


<210> 44
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 44
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgatattg tcctcactca atcgccggac tcactggcgg tgtccctcgg agagagggcg      120

acgatcaatt gccgggcttc cgaatccgtc gataactacg gaaacacctt tatgcactgg      180

taccaacaga agccaggaca gccaccaaag ctgttgatct accgcgcttc aaaccttgag      240

tcgggtgtgc cggaccgctt cagcggcagc ggttccagaa ccgactttac cctcaccatc      300

agctcgctgc aggccgaaga tgtcgccgtc tattactgcc aacagagcaa cgaagatccg      360

cctactttcg gacaggggac taaactggaa atcaagggcg gaggaggctc gggtggagga      420

ggatcgggag gaggcgggtc cggtggtggc ggatcgcaaa tccagctggt gcagtccggc      480

gcagaagtga agaagccggg agcgtccgtg aaagtgagct gcaaggcctc agggtacatc      540

ttcaccaatt acggcatgaa ttgggtgcgg caggcacccg gacagcgcct ggagtggatg      600

ggctggatca acacttacac cggggaaagc acgtactcgg ccgacttcaa aggacgggtg      660

accattaccc tggatacctc ggcctcaacc gcttacatgg agctctcatc acttagatcc      720

gaggacactg ccgtctacta ctgtgcaagg agcggaggct acgaccctat ggactattgg      780

ggacaaggca ctactgtgac tgtgtcgtcc ggctcgcacc accatcacca tcatcatcac      840

cac                                                                    843


<210> 45
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly 
145                 150                 155                 160 


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                165                 170                 175     


Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly 
        195                 200                 205             


Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu 
    210                 215                 220                 


Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ser 
            260                 265                 270         


His His His His His His His His His 
        275                 280     


<210> 46
<211> 1479
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 46
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgatattg tcctcactca atcgccggac tcactggcgg tgtccctcgg agagagggcg      120

acgatcaatt gccgggcttc cgaatccgtc gataactacg gaaacacctt tatgcactgg      180

taccaacaga agccaggaca gccaccaaag ctgttgatct accgcgcttc aaaccttgag      240

tcgggtgtgc cggaccgctt cagcggcagc ggttccagaa ccgactttac cctcaccatc      300

agctcgctgc aggccgaaga tgtcgccgtc tattactgcc aacagagcaa cgaagatccg      360

cctactttcg gacaggggac taaactggaa atcaagggcg gaggaggctc gggtggagga      420

ggatcgggag gaggcgggtc cggtggtggc ggatcgcaaa tccagctggt gcagtccggc      480

gcagaagtga agaagccggg agcgtccgtg aaagtgagct gcaaggcctc agggtacatc      540

ttcaccaatt acggcatgaa ttgggtgcgg caggcacccg gacagcgcct ggagtggatg      600

ggctggatca acacttacac cggggaaagc acgtactcgg ccgacttcaa aggacgggtg      660

accattaccc tggatacctc ggcctcaacc gcttacatgg agctctcatc acttagatcc      720

gaggacactg ccgtctacta ctgtgcaagg agcggaggct acgaccctat ggactattgg      780

ggacaaggca ctactgtgac tgtgtcgtcc accactaccc cagcaccgag gccacccacc      840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca      900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc      960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag     1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact     1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa     1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct acaagcaggg gcagaaccag     1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga     1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac     1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa     1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac     1440

acctatgacg ctcttcacat gcaggccctg ccgcctcgg                            1479


<210> 47
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly 
145                 150                 155                 160 


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                165                 170                 175     


Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly 
        195                 200                 205             


Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu 
    210                 215                 220                 


Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210> 48
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
145                 150                 155                 160 


Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser 
            180                 185                 190         


Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser 
        195                 200                 205             


Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 


<210> 49
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 49
gaaattgtgc tcacgcaatc acccgccact ctgtcgcttt ccccgggaga gcgggccacc       60

ctctcctgcc gcgcttcgga atcggtcgac aattacggaa atacttttat gcactggtac      120

caacagaagc cagggcaggc gccaaggctg ctgatctaca gagcctcgaa cctcgaaagc      180

ggcatccctg cgcggttcag cggtagcgga agccgcaccg atttcaccct gaccatctca      240

tcactggagc cggaggatgt ggcagtgtac tattgtcagc agtcgaacga ggacccgccg      300

actttcgggc agggaaccaa gctggaaatc aagggtggag gagggagcgg cggaggagga      360

tcgggaggag gaggcagcgg aggcggagga tcgcaaatcc aacttgtcca gtcgggctcc      420

gaactcaaaa agcctggcgc gtccgtgaag gtcagctgca aagcatcagg atacatcttc      480

actaactacg gtatgaattg ggtcagacag gctccgggtc agggtctgga gtggatggga      540

tggattaaca cctacactgg ggaatcgact tactccgcgg acttcaaagg gcggttcgtg      600

ttttcactgg acaccagcgt gtccaccgct tacttgcaaa tcaacgccct caaggccgag      660

gacaccgccg tgtactactg cgcacgctca ggcggatacg atccaatgga ctactgggga      720

cagggcacta cggtgactgt gtcctcc                                          747


<210> 50
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 50
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgaaattg tgctcacgca atcacccgcc actctgtcgc tttccccggg agagcgggcc      120

accctctcct gccgcgcttc ggaatcggtc gacaattacg gaaatacttt tatgcactgg      180

taccaacaga agccagggca ggcgccaagg ctgctgatct acagagcctc gaacctcgaa      240

agcggcatcc ctgcgcggtt cagcggtagc ggaagccgca ccgatttcac cctgaccatc      300

tcatcactgg agccggagga tgtggcagtg tactattgtc agcagtcgaa cgaggacccg      360

ccgactttcg ggcagggaac caagctggaa atcaagggtg gaggagggag cggcggagga      420

ggatcgggag gaggaggcag cggaggcgga ggatcgcaaa tccaacttgt ccagtcgggc      480

tccgaactca aaaagcctgg cgcgtccgtg aaggtcagct gcaaagcatc aggatacatc      540

ttcactaact acggtatgaa ttgggtcaga caggctccgg gtcagggtct ggagtggatg      600

ggatggatta acacctacac tggggaatcg acttactccg cggacttcaa agggcggttc      660

gtgttttcac tggacaccag cgtgtccacc gcttacttgc aaatcaacgc cctcaaggcc      720

gaggacaccg ccgtgtacta ctgcgcacgc tcaggcggat acgatccaat ggactactgg      780

ggacagggca ctacggtgac tgtgtcctcc ggctcgcacc accatcacca tcatcatcac      840

cac                                                                    843


<210> 51
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                165                 170                 175     


Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly 
        195                 200                 205             


Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu 
    210                 215                 220                 


Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ser 
            260                 265                 270         


His His His His His His His His His 
        275                 280     


<210> 52
<211> 1479
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 52
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgaaattg tgctcacgca atcacccgcc actctgtcgc tttccccggg agagcgggcc      120

accctctcct gccgcgcttc ggaatcggtc gacaattacg gaaatacttt tatgcactgg      180

taccaacaga agccagggca ggcgccaagg ctgctgatct acagagcctc gaacctcgaa      240

agcggcatcc ctgcgcggtt cagcggtagc ggaagccgca ccgatttcac cctgaccatc      300

tcatcactgg agccggagga tgtggcagtg tactattgtc agcagtcgaa cgaggacccg      360

ccgactttcg ggcagggaac caagctggaa atcaagggtg gaggagggag cggcggagga      420

ggatcgggag gaggaggcag cggaggcgga ggatcgcaaa tccaacttgt ccagtcgggc      480

tccgaactca aaaagcctgg cgcgtccgtg aaggtcagct gcaaagcatc aggatacatc      540

ttcactaact acggtatgaa ttgggtcaga caggctccgg gtcagggtct ggagtggatg      600

ggatggatta acacctacac tggggaatcg acttactccg cggacttcaa agggcggttc      660

gtgttttcac tggacaccag cgtgtccacc gcttacttgc aaatcaacgc cctcaaggcc      720

gaggacaccg ccgtgtacta ctgcgcacgc tcaggcggat acgatccaat ggactactgg      780

ggacagggca ctacggtgac tgtgtcctcc accactaccc cagcaccgag gccacccacc      840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca      900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc      960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag     1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact     1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa     1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct acaagcaggg gcagaaccag     1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga     1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac     1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa     1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac     1440

acctatgacg ctcttcacat gcaggccctg ccgcctcgg                            1479


<210> 53
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                165                 170                 175     


Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly 
        195                 200                 205             


Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu 
    210                 215                 220                 


Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210> 54
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
145                 150                 155                 160 


Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
                165                 170                 175     


Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser 
            180                 185                 190         


Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu Asp Thr Ser Ala Ser 
        195                 200                 205             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 


<210> 55
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 55
gagatcgtct tgacgcaatc gccagccacc ctgtccctga gcccaggcga gcgcgccacc       60

ctcagctgtc gggcgagcga aagcgtggac aattacggaa acacctttat gcactggtac      120

caacagaaac cggggcaggc tccgcgcctc ctcatctacc gcgcatccaa tctggaatca      180

ggaatccccg cgaggttctc cggtagcgga tcgcggactg actttactct gaccatctcg      240

tcccttgaac cggaggatgt ggctgtgtat tactgccagc agtcaaacga ggaccctcca      300

actttcgggc agggaaccaa gctcgaaatc aagggcggtg gcggaagcgg aggaggagga      360

tcaggcggag gcggctcagg cggtggaggt tcacaaattc aactggtgca gtcgggagcg      420

gaggtcaaga agccgggagc ctcagtgaaa gtgagctgca aggcttcggg ttacattttc      480

actaattacg gcatgaactg ggtgaggcag gcccctggcc aacggttgga atggatggga      540

tggatcaaca cctacaccgg ggagtcgact tactccgcgg acttcaaggg gagagtcacg      600

atcaccctgg atacgtccgc aagcactgcc tacatggaac tgtcctccct gcgctcggaa      660

gataccgcag tctactactg cgccagatcg ggcggatatg acccgatgga ctactgggga      720

cagggaacta ctgtcaccgt gtcctcg                                          747


<210> 56
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 56
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgagatcg tcttgacgca atcgccagcc accctgtccc tgagcccagg cgagcgcgcc      120

accctcagct gtcgggcgag cgaaagcgtg gacaattacg gaaacacctt tatgcactgg      180

taccaacaga aaccggggca ggctccgcgc ctcctcatct accgcgcatc caatctggaa      240

tcaggaatcc ccgcgaggtt ctccggtagc ggatcgcgga ctgactttac tctgaccatc      300

tcgtcccttg aaccggagga tgtggctgtg tattactgcc agcagtcaaa cgaggaccct      360

ccaactttcg ggcagggaac caagctcgaa atcaagggcg gtggcggaag cggaggagga      420

ggatcaggcg gaggcggctc aggcggtgga ggttcacaaa ttcaactggt gcagtcggga      480

gcggaggtca agaagccggg agcctcagtg aaagtgagct gcaaggcttc gggttacatt      540

ttcactaatt acggcatgaa ctgggtgagg caggcccctg gccaacggtt ggaatggatg      600

ggatggatca acacctacac cggggagtcg acttactccg cggacttcaa ggggagagtc      660

acgatcaccc tggatacgtc cgcaagcact gcctacatgg aactgtcctc cctgcgctcg      720

gaagataccg cagtctacta ctgcgccaga tcgggcggat atgacccgat ggactactgg      780

ggacagggaa ctactgtcac cgtgtcctcg ggctcgcacc accatcacca tcatcatcac      840

cac                                                                    843


<210> 57
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly 
145                 150                 155                 160 


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                165                 170                 175     


Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly 
        195                 200                 205             


Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu 
    210                 215                 220                 


Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ser 
            260                 265                 270         


His His His His His His His His His 
        275                 280     


<210> 58
<211> 1479
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 58
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgagatcg tcttgacgca atcgccagcc accctgtccc tgagcccagg cgagcgcgcc      120

accctcagct gtcgggcgag cgaaagcgtg gacaattacg gaaacacctt tatgcactgg      180

taccaacaga aaccggggca ggctccgcgc ctcctcatct accgcgcatc caatctggaa      240

tcaggaatcc ccgcgaggtt ctccggtagc ggatcgcgga ctgactttac tctgaccatc      300

tcgtcccttg aaccggagga tgtggctgtg tattactgcc agcagtcaaa cgaggaccct      360

ccaactttcg ggcagggaac caagctcgaa atcaagggcg gtggcggaag cggaggagga      420

ggatcaggcg gaggcggctc aggcggtgga ggttcacaaa ttcaactggt gcagtcggga      480

gcggaggtca agaagccggg agcctcagtg aaagtgagct gcaaggcttc gggttacatt      540

ttcactaatt acggcatgaa ctgggtgagg caggcccctg gccaacggtt ggaatggatg      600

ggatggatca acacctacac cggggagtcg acttactccg cggacttcaa ggggagagtc      660

acgatcaccc tggatacgtc cgcaagcact gcctacatgg aactgtcctc cctgcgctcg      720

gaagataccg cagtctacta ctgcgccaga tcgggcggat atgacccgat ggactactgg      780

ggacagggaa ctactgtcac cgtgtcctcg accactaccc cagcaccgag gccacccacc      840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca      900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc      960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag     1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact     1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa     1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct acaagcaggg gcagaaccag     1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga     1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac     1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa     1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac     1440

acctatgacg ctcttcacat gcaggccctg ccgcctcgg                            1479


<210> 59
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 59
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly 
145                 150                 155                 160 


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                165                 170                 175     


Ser Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly 
        195                 200                 205             


Glu Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu 
    210                 215                 220                 


Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210> 60
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 60
Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ala Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn 
145                 150                 155                 160 


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
            180                 185                 190         


Ala Ser Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
    210                 215                 220                 


Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210> 61
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 61
cagatccagt tggtccagtc aggctccgaa ctgaaaaagc cgggtgcatc cgtcaaggtg       60

tcgtgcaaag cctccggtta cattttcacc aactacggca tgaactgggt ccgccaggcc      120

cctgggcagg gactcgaatg gatggggtgg atcaacactt acaccggaga gtcgacttac      180

tcggccgatt tcaagggacg gttcgtgttt tccctggaca cttcagtctc gaccgcatat      240

ctccaaatca acgcgcttaa ggcggaagat actgctgtct actactgcgc cagatcagga      300

ggttacgatc caatggacta ctggggacag ggcaccactg tgacggtgtc gtcgggagga      360

ggaggatcgg gcggaggcgg gtccggcggt ggagggagcg gaggaggcgg aagcgacatc      420

gtgctgaccc agtcgccaga tagcctggcg gtgtccttgg gtgagagggc taccatcaat      480

tgtcgcgcgt cagagtccgt ggacaattac gggaatacct tcatgcactg gtaccaacaa      540

aagcccggac aaccgccgaa gctgctgatc tacagagcaa gcaacctcga atcaggagtg      600

ccggaccgct ttagcgggtc aggaagccgg actgacttca ccctgactat ctcctcgctc      660

caggccgagg acgtggccgt gtattactgc cagcagagca acgaagatcc tccaacgttc      720

ggccaaggaa ccaaactgga gattaag                                          747


<210> 62
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 62
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccagatcc agttggtcca gtcaggctcc gaactgaaaa agccgggtgc atccgtcaag      120

gtgtcgtgca aagcctccgg ttacattttc accaactacg gcatgaactg ggtccgccag      180

gcccctgggc agggactcga atggatgggg tggatcaaca cttacaccgg agagtcgact      240

tactcggccg atttcaaggg acggttcgtg ttttccctgg acacttcagt ctcgaccgca      300

tatctccaaa tcaacgcgct taaggcggaa gatactgctg tctactactg cgccagatca      360

ggaggttacg atccaatgga ctactgggga cagggcacca ctgtgacggt gtcgtcggga      420

ggaggaggat cgggcggagg cgggtccggc ggtggaggga gcggaggagg cggaagcgac      480

atcgtgctga cccagtcgcc agatagcctg gcggtgtcct tgggtgagag ggctaccatc      540

aattgtcgcg cgtcagagtc cgtggacaat tacgggaata ccttcatgca ctggtaccaa      600

caaaagcccg gacaaccgcc gaagctgctg atctacagag caagcaacct cgaatcagga      660

gtgccggacc gctttagcgg gtcaggaagc cggactgact tcaccctgac tatctcctcg      720

ctccaggccg aggacgtggc cgtgtattac tgccagcaga gcaacgaaga tcctccaacg      780

ttcggccaag gaaccaaact ggagattaag ggctcgcacc accatcacca tcatcatcac      840

cac                                                                    843


<210> 63
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 63
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser 
                85                  90                  95      


Val Ser Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu 
                165                 170                 175     


Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
            180                 185                 190         


Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu 
                245                 250                 255     


Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser 
            260                 265                 270         


His His His His His His His His His 
        275                 280     


<210> 64
<211> 1479
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 64
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccagatcc agttggtcca gtcaggctcc gaactgaaaa agccgggtgc atccgtcaag      120

gtgtcgtgca aagcctccgg ttacattttc accaactacg gcatgaactg ggtccgccag      180

gcccctgggc agggactcga atggatgggg tggatcaaca cttacaccgg agagtcgact      240

tactcggccg atttcaaggg acggttcgtg ttttccctgg acacttcagt ctcgaccgca      300

tatctccaaa tcaacgcgct taaggcggaa gatactgctg tctactactg cgccagatca      360

ggaggttacg atccaatgga ctactgggga cagggcacca ctgtgacggt gtcgtcggga      420

ggaggaggat cgggcggagg cgggtccggc ggtggaggga gcggaggagg cggaagcgac      480

atcgtgctga cccagtcgcc agatagcctg gcggtgtcct tgggtgagag ggctaccatc      540

aattgtcgcg cgtcagagtc cgtggacaat tacgggaata ccttcatgca ctggtaccaa      600

caaaagcccg gacaaccgcc gaagctgctg atctacagag caagcaacct cgaatcagga      660

gtgccggacc gctttagcgg gtcaggaagc cggactgact tcaccctgac tatctcctcg      720

ctccaggccg aggacgtggc cgtgtattac tgccagcaga gcaacgaaga tcctccaacg      780

ttcggccaag gaaccaaact ggagattaag accactaccc cagcaccgag gccacccacc      840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca      900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc      960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag     1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact     1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa     1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct acaagcaggg gcagaaccag     1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga     1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac     1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa     1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac     1440

acctatgacg ctcttcacat gcaggccctg ccgcctcgg                            1479


<210> 65
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 65
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser 
                85                  90                  95      


Val Ser Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu 
                165                 170                 175     


Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
            180                 185                 190         


Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu 
                245                 250                 255     


Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210> 66
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 66
Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ala Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg 
            180                 185                 190         


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210> 67
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 67
cagatccaac tggtgcaatc aggatcggag ctgaagaagc ctggggcttc agtgaaagtc       60

agctgcaaag cctccggtta catcttcacc aactacggca tgaactgggt gcgccaggcc      120

cctggacagg gactcgaatg gatggggtgg atcaacacct ataccgggga atccacgtac      180

tcagcagatt tcaagggacg cttcgtcttt tcgctggata cctccgtgtc cactgcgtac      240

ctccaaatca atgccctcaa agccgaagat actgcggtct actactgcgc acggagcgga      300

ggctacgacc cgatggacta ctggggacag ggaaccacgg tgaccgtgtc cagcggagga      360

ggcggatcgg gaggcggtgg ttcaggcggt ggaggcagcg gcggaggtgg aagcgaaatc      420

gtcttgactc agagcccagc gactttgtcc ctgtcgcccg gagagcgggc aactctgtca      480

tgccgcgctt cggaatcggt ggacaactat ggaaacacct ttatgcactg gtaccaacag      540

aagccgggac aagccccgag acttctgatc taccgggcct cgaatctcga aagcggcatc      600

ccggctagat tctcggggtc gggatcaagg accgacttca ctcttactat ttcctcactg      660

gagccagaag atgtggcggt gtactactgt cagcagtcca atgaggaccc gccaactttc      720

gggcagggca ccaagctgga gattaag                                          747


<210> 68
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 68
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccagatcc aactggtgca atcaggatcg gagctgaaga agcctggggc ttcagtgaaa      120

gtcagctgca aagcctccgg ttacatcttc accaactacg gcatgaactg ggtgcgccag      180

gcccctggac agggactcga atggatgggg tggatcaaca cctataccgg ggaatccacg      240

tactcagcag atttcaaggg acgcttcgtc ttttcgctgg atacctccgt gtccactgcg      300

tacctccaaa tcaatgccct caaagccgaa gatactgcgg tctactactg cgcacggagc      360

ggaggctacg acccgatgga ctactgggga cagggaacca cggtgaccgt gtccagcgga      420

ggaggcggat cgggaggcgg tggttcaggc ggtggaggca gcggcggagg tggaagcgaa      480

atcgtcttga ctcagagccc agcgactttg tccctgtcgc ccggagagcg ggcaactctg      540

tcatgccgcg cttcggaatc ggtggacaac tatggaaaca cctttatgca ctggtaccaa      600

cagaagccgg gacaagcccc gagacttctg atctaccggg cctcgaatct cgaaagcggc      660

atcccggcta gattctcggg gtcgggatca aggaccgact tcactcttac tatttcctca      720

ctggagccag aagatgtggc ggtgtactac tgtcagcagt ccaatgagga cccgccaact      780

ttcgggcagg gcaccaagct ggagattaag ggctcgcacc accatcacca tcatcatcac      840

cac                                                                    843


<210> 69
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 69
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser 
                85                  90                  95      


Val Ser Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
            180                 185                 190         


Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        195                 200                 205             


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu 
                245                 250                 255     


Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser 
            260                 265                 270         


His His His His His His His His His 
        275                 280     


<210> 70
<211> 1479
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 70
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccagatcc aactggtgca atcaggatcg gagctgaaga agcctggggc ttcagtgaaa      120

gtcagctgca aagcctccgg ttacatcttc accaactacg gcatgaactg ggtgcgccag      180

gcccctggac agggactcga atggatgggg tggatcaaca cctataccgg ggaatccacg      240

tactcagcag atttcaaggg acgcttcgtc ttttcgctgg atacctccgt gtccactgcg      300

tacctccaaa tcaatgccct caaagccgaa gatactgcgg tctactactg cgcacggagc      360

ggaggctacg acccgatgga ctactgggga cagggaacca cggtgaccgt gtccagcgga      420

ggaggcggat cgggaggcgg tggttcaggc ggtggaggca gcggcggagg tggaagcgaa      480

atcgtcttga ctcagagccc agcgactttg tccctgtcgc ccggagagcg ggcaactctg      540

tcatgccgcg cttcggaatc ggtggacaac tatggaaaca cctttatgca ctggtaccaa      600

cagaagccgg gacaagcccc gagacttctg atctaccggg cctcgaatct cgaaagcggc      660

atcccggcta gattctcggg gtcgggatca aggaccgact tcactcttac tatttcctca      720

ctggagccag aagatgtggc ggtgtactac tgtcagcagt ccaatgagga cccgccaact      780

ttcgggcagg gcaccaagct ggagattaag accactaccc cagcaccgag gccacccacc      840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca      900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc      960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag     1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact     1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa     1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct acaagcaggg gcagaaccag     1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga     1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac     1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa     1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac     1440

acctatgacg ctcttcacat gcaggccctg ccgcctcgg                            1479


<210> 71
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 71
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser 
                85                  90                  95      


Val Ser Thr Ala Tyr Leu Gln Ile Asn Ala Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
            180                 185                 190         


Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        195                 200                 205             


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu 
                245                 250                 255     


Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210> 72
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 72
Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Leu Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn 
145                 150                 155                 160 


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg 
            180                 185                 190         


Ala Ser Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
    210                 215                 220                 


Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210> 73
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 73
cagatccagc tggtgcagtc gggagctgaa gtgaaaaagc cgggagcatc ggtgaaggtg       60

tcatgcaaag ccagcggtta catcttcact aactacggta tgaactgggt gagacaagcg      120

cctggccaga gattggaatg gatgggatgg atcaatacct acaccgggga atcaacttac      180

agcgccgact tcaagggacg cgtgaccatc acgctggaca cctccgcgtc cactgcctac      240

atggagctct cgtcattgcg gagcgaggac accgccgtct actactgcgc acggtcagga      300

gggtacgatc cgatggacta ctggggacag ggcactaccg tcaccgtgag ctccggtgga      360

ggcggcagcg gcggtggcgg atcaggtgga ggaggatcag gaggaggagg gtccgatatc      420

gtgcttactc agtcacccga ttcgctggca gtctccctcg gagaacgcgc caccatcaat      480

tgtcgcgcgt ccgaatccgt cgacaactac ggcaacacct ttatgcactg gtaccaacag      540

aagcctggac aaccgccaaa actgctgatc taccgcgcta gcaacctcga atcgggcgtg      600

ccagataggt tctcgggctc ggggagccgg acggatttta ctctgactat ttcgtccctc      660

caagcagagg acgtcgccgt gtattactgc cagcaatcga atgaggaccc gccaactttc      720

ggacagggga ccaagctgga gattaag                                          747


<210> 74
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 74
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccagatcc agctggtgca gtcgggagct gaagtgaaaa agccgggagc atcggtgaag      120

gtgtcatgca aagccagcgg ttacatcttc actaactacg gtatgaactg ggtgagacaa      180

gcgcctggcc agagattgga atggatggga tggatcaata cctacaccgg ggaatcaact      240

tacagcgccg acttcaaggg acgcgtgacc atcacgctgg acacctccgc gtccactgcc      300

tacatggagc tctcgtcatt gcggagcgag gacaccgccg tctactactg cgcacggtca      360

ggagggtacg atccgatgga ctactgggga cagggcacta ccgtcaccgt gagctccggt      420

ggaggcggca gcggcggtgg cggatcaggt ggaggaggat caggaggagg agggtccgat      480

atcgtgctta ctcagtcacc cgattcgctg gcagtctccc tcggagaacg cgccaccatc      540

aattgtcgcg cgtccgaatc cgtcgacaac tacggcaaca cctttatgca ctggtaccaa      600

cagaagcctg gacaaccgcc aaaactgctg atctaccgcg ctagcaacct cgaatcgggc      660

gtgccagata ggttctcggg ctcggggagc cggacggatt ttactctgac tatttcgtcc      720

ctccaagcag aggacgtcgc cgtgtattac tgccagcaat cgaatgagga cccgccaact      780

ttcggacagg ggaccaagct ggagattaag ggctcgcacc accatcacca tcatcatcac      840

cac                                                                    843


<210> 75
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 75
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Arg Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu Asp Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu 
                165                 170                 175     


Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
            180                 185                 190         


Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu 
                245                 250                 255     


Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser 
            260                 265                 270         


His His His His His His His His His 
        275                 280     


<210> 76
<211> 1479
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 76
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccagatcc agctggtgca gtcgggagct gaagtgaaaa agccgggagc atcggtgaag      120

gtgtcatgca aagccagcgg ttacatcttc actaactacg gtatgaactg ggtgagacaa      180

gcgcctggcc agagattgga atggatggga tggatcaata cctacaccgg ggaatcaact      240

tacagcgccg acttcaaggg acgcgtgacc atcacgctgg acacctccgc gtccactgcc      300

tacatggagc tctcgtcatt gcggagcgag gacaccgccg tctactactg cgcacggtca      360

ggagggtacg atccgatgga ctactgggga cagggcacta ccgtcaccgt gagctccggt      420

ggaggcggca gcggcggtgg cggatcaggt ggaggaggat caggaggagg agggtccgat      480

atcgtgctta ctcagtcacc cgattcgctg gcagtctccc tcggagaacg cgccaccatc      540

aattgtcgcg cgtccgaatc cgtcgacaac tacggcaaca cctttatgca ctggtaccaa      600

cagaagcctg gacaaccgcc aaaactgctg atctaccgcg ctagcaacct cgaatcgggc      660

gtgccagata ggttctcggg ctcggggagc cggacggatt ttactctgac tatttcgtcc      720

ctccaagcag aggacgtcgc cgtgtattac tgccagcaat cgaatgagga cccgccaact      780

ttcggacagg ggaccaagct ggagattaag accactaccc cagcaccgag gccacccacc      840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca      900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc      960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag     1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact     1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa     1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct acaagcaggg gcagaaccag     1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga     1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac     1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa     1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac     1440

acctatgacg ctcttcacat gcaggccctg ccgcctcgg                            1479


<210> 77
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 77
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Arg Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu Asp Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu 
                165                 170                 175     


Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
            180                 185                 190         


Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu 
                245                 250                 255     


Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210> 78
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 78
Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Leu Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg 
            180                 185                 190         


Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210> 79
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 79
cagatccagc tggtgcaatc gggagctgaa gtgaagaagc ccggagcttc agtcaaagtc       60

agctgcaagg cgtcgggcta tatcttcacc aactacggga tgaactgggt gcggcaggcc      120

cctggacaaa gactggaatg gatgggatgg atcaacactt atactggcga gagcacgtac      180

tcagccgact ttaagggacg ggtgactatc accctcgata cctccgcctc cactgcgtac      240

atggaactct cgtccttgcg ctccgaggac actgccgtgt actactgcgc caggtcgggt      300

ggctacgatc cgatggatta ctggggtcaa ggaaccaccg tcactgtgtc gtccggcgga      360

ggcgggagcg gaggtggtgg ttcgggagga ggagggtcag gcggaggagg cagcgaaatc      420

gtgctgaccc aaagcccggc aactctgtca ctcagcccag gggagagggc aaccctgtca      480

tgtcgggcta gcgaatccgt ggacaattac ggaaacacgt ttatgcactg gtaccaacag      540

aaaccaggac aggcgcctag acttctcatc taccgcgcga gcaatttgga atccggcatc      600

ccagcccgct tctccgggtc ggggtcacgc accgatttca ctctgaccat ttcctccctg      660

gaacccgagg acgtggcagt ctactactgc cagcagtcga atgaggaccc gccgaccttc      720

ggacagggca ccaagctgga gattaag                                          747


<210> 80
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 80
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccagatcc agctggtgca atcgggagct gaagtgaaga agcccggagc ttcagtcaaa      120

gtcagctgca aggcgtcggg ctatatcttc accaactacg ggatgaactg ggtgcggcag      180

gcccctggac aaagactgga atggatggga tggatcaaca cttatactgg cgagagcacg      240

tactcagccg actttaaggg acgggtgact atcaccctcg atacctccgc ctccactgcg      300

tacatggaac tctcgtcctt gcgctccgag gacactgccg tgtactactg cgccaggtcg      360

ggtggctacg atccgatgga ttactggggt caaggaacca ccgtcactgt gtcgtccggc      420

ggaggcggga gcggaggtgg tggttcggga ggaggagggt caggcggagg aggcagcgaa      480

atcgtgctga cccaaagccc ggcaactctg tcactcagcc caggggagag ggcaaccctg      540

tcatgtcggg ctagcgaatc cgtggacaat tacggaaaca cgtttatgca ctggtaccaa      600

cagaaaccag gacaggcgcc tagacttctc atctaccgcg cgagcaattt ggaatccggc      660

atcccagccc gcttctccgg gtcggggtca cgcaccgatt tcactctgac catttcctcc      720

ctggaacccg aggacgtggc agtctactac tgccagcagt cgaatgagga cccgccgacc      780

ttcggacagg gcaccaagct ggagattaag ggctcgcacc accatcacca tcatcatcac      840

cac                                                                    843


<210> 81
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 81
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Arg Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu Asp Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
            180                 185                 190         


Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        195                 200                 205             


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu 
                245                 250                 255     


Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser 
            260                 265                 270         


His His His His His His His His His 
        275                 280     


<210> 82
<211> 1479
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 82
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccagatcc agctggtgca atcgggagct gaagtgaaga agcccggagc ttcagtcaaa      120

gtcagctgca aggcgtcggg ctatatcttc accaactacg ggatgaactg ggtgcggcag      180

gcccctggac aaagactgga atggatggga tggatcaaca cttatactgg cgagagcacg      240

tactcagccg actttaaggg acgggtgact atcaccctcg atacctccgc ctccactgcg      300

tacatggaac tctcgtcctt gcgctccgag gacactgccg tgtactactg cgccaggtcg      360

ggtggctacg atccgatgga ttactggggt caaggaacca ccgtcactgt gtcgtccggc      420

ggaggcggga gcggaggtgg tggttcggga ggaggagggt caggcggagg aggcagcgaa      480

atcgtgctga cccaaagccc ggcaactctg tcactcagcc caggggagag ggcaaccctg      540

tcatgtcggg ctagcgaatc cgtggacaat tacggaaaca cgtttatgca ctggtaccaa      600

cagaaaccag gacaggcgcc tagacttctc atctaccgcg cgagcaattt ggaatccggc      660

atcccagccc gcttctccgg gtcggggtca cgcaccgatt tcactctgac catttcctcc      720

ctggaacccg aggacgtggc agtctactac tgccagcagt cgaatgagga cccgccgacc      780

ttcggacagg gcaccaagct ggagattaag accactaccc cagcaccgag gccacccacc      840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca      900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc      960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag     1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact     1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa     1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct acaagcaggg gcagaaccag     1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga     1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac     1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa     1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac     1440

acctatgacg ctcttcacat gcaggccctg ccgcctcgg                            1479


<210> 83
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 83
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Arg Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Tyr Ser Ala Asp Phe Lys Gly Arg Val Thr Ile Thr Leu Asp Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly 
            180                 185                 190         


Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        195                 200                 205             


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn Glu 
                245                 250                 255     


Asp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210> 84
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 84
Ser Tyr Trp Met Asn 
1               5   


<210> 85
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 85
Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210> 86
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 86
Gly Asn Trp Asp Asp Tyr 
1               5       


<210> 87
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 87
Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala 
1               5                   10      


<210> 88
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 88
Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210> 89
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 89
Gln Gln His Asn Lys Tyr Pro Tyr Thr 
1               5                   


<210> 90
<211> 400
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(400) 
<223> /note="This sequence may encompass between 100 and 400 
      nucleotides"

<220>
<221> variation
<222> (101)..(400) 
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(400) 
<223> /note="Variant bases given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> misc_feature
<222> (1)..(400) 
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 90
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            400


<210> 91
<211> 2019
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 91
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cctggatccc aggtgcagct gcagcagcct ggcgctgaac tcgtgcggcc aggcgcttct      120

gtgaagctga gctgtaaagc cagcggctac accttcacca gctactggat gaactgggtc      180

aagcagcggc ccgaccaggg cctggagtgg atcggcagaa tcgaccccta cgacagcgag      240

acacactaca accagaagtt caaggacaag gccatcctga ccgtggacaa gagcagcagc      300

accgcctaca tgcagctgtc cagcctgacc agcgaggaca gcgccgtgta ctactgcgcc      360

aggggcaact gggacgacta ttggggccag ggcaccaccc tgacagtgtc tagcggaggc      420

ggaggatctg gcggcggagg aagttctggc ggaggctccg acgtgcagat cacccagagc      480

cctagctacc tggccgcctc tcctggcgag acaatcacca tcaactgccg ggccagcaag      540

agcatctcca aggacctggc ctggtatcag gaaaagcccg gcaagaccaa caagctgctg      600

atctacagcg gcagcaccct gcagagcggc atccccagca gattttccgg cagcggctcc      660

ggcaccgact tcaccctgac catcagctcc ctggaacccg aggactttgc catgtactat      720

tgccagcagc acaacaagta cccttacacc ttcggcggag gcaccaagct ggaaatcaag      780

gccagctccg gagagagcaa gtacggccct ccctgccccc cttgccctgc ccccgagttc      840

ctgggcggac ccagcgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc      900

cggacccccg aggtgacctg tgtggtggtg gacgtgtccc aggaggaccc cgaggtccag      960

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggag     1020

cagttcaata gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg     1080

aacggcaagg aatacaagtg taaggtgtcc aacaagggcc tgcccagcag catcgagaaa     1140

accatcagca aggccaaggg ccagcctcgg gagccccagg tgtacaccct gccccctagc     1200

caagaggaga tgaccaagaa ccaggtgtcc ctgacctgcc tggtgaaggg cttctacccc     1260

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     1320

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gccggctgac cgtggacaag     1380

agccggtggc aggagggcaa cgtctttagc tgctccgtga tgcacgaggc cctgcacaac     1440

cactacaccc agaagagcct gagcctgtcc ctgggcaaga tggatatcta catctgggcg     1500

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1560

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1620

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1680

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1740

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1800

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1860

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1920

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1980

acctacgacg cccttcacat gcaggccctg ccccctcgc                            2019


<210> 92
<211> 111
<212> PRT
<213> Mus musculus

<400> 92
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210> 93
<211> 118
<212> PRT
<213> Mus musculus

<400> 93
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210> 94
<211> 2003
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 94
ggcagcggag agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc       60

cctagagcca ccatggccct gcctgtgaca gccctgctgc tgcctctggc tctgctgctg      120

catgccgcta gacccggatc cgacatcgtg ctgacacaga gccctgcttc cctggccgtg      180

tccctgggac agagagccac aatcagctgc agggccagcg agagcgtgga caactacggc      240

aacaccttca tgcactggta tcagcagaag cccggccagc cccccaagct gctgatctac      300

agagccagca acctggaaag cggcatcccc gccagatttt ccggcagcgg cagcagaacc      360

gacttcaccc tgaccatcaa ccccgtggaa gccgacgacg tggccaccta ctactgccag      420

cagagcaacg aggacccccc cacatttgga gccggcacca agctggaact gaagggcgga      480

ggcggatctg gcggcggagg atcttctggg ggaggctctc agattcagct ggtgcagagc      540

ggcccagagc tgaagaaacc cggcgagaca gtgaagatct cctgcaaggc ctccggctac      600

atcttcacca attacggcat gaactgggtc aagcaggccc ctggcaagag cttcaagtgg      660

atgggctgga tcaacaccta caccggcgag agcacctaca gcgccgactt caagggcaga      720

ttcgccttca gcctggaaac cagcgccagc accgcctacc tgcacatcaa cgacctgaag      780

aacgaggaca ccgccaccta tttctgcgcc agaagcggcg gctacgaccc catggattat      840

tggggccagg gcaccagcgt gaccgtgtcc tctgctagct ccggaaccac gacgccagcg      900

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      960

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat     1020

atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     1080

accctttact gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1140

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1200

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1260

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1320

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1380

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1440

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1500

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaagtc     1560

gacagctcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc ctaagtccaa     1620

ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc taataaaaaa     1680

catttatttt cattgctgcg tcgagagctc gctttcttgc tgtccaattt ctattaaagg     1740

ttcctttgtt ccctaagtcc aactactaaa ctgggggata ttatgaaggg ccttgagcat     1800

ctggattctg cctaataaaa aacatttatt ttcattgctg cctcgacgaa ttcaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaaa aaa                                             2003


<210> 95
<211> 494
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 95
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn 
65                  70                  75                  80  


Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
            180                 185                 190         


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
        195                 200                 205             


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
    210                 215                 220                 


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ser Gly Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210> 96
<211> 2019
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 96
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cctggatccc aggtgcagct gcagcagcct ggcgctgaac tcgtgcggcc aggcgcttct      120

gtgaagctga gctgtaaagc cagcggctac accttcacca gctactggat gaactgggtc      180

aagcagcggc ccgaccaggg cctggagtgg atcggcagaa tcgaccccta cgacagcgag      240

acacactaca accagaagtt caaggacaag gccatcctga ccgtggacaa gagcagcagc      300

accgcctaca tgcagctgtc cagcctgacc agcgaggaca gcgccgtgta ctactgcgcc      360

aggggcaact gggacgacta ttggggccag ggcaccaccc tgacagtgtc tagcggaggc      420

ggaggatctg gcggcggagg aagttctggc ggaggctccg acgtgcagat cacccagagc      480

cctagctacc tggccgcctc tcctggcgag acaatcacca tcaactgccg ggccagcaag      540

agcatctcca aggacctggc ctggtatcag gaaaagcccg gcaagaccaa caagctgctg      600

atctacagcg gcagcaccct gcagagcggc atccccagca gattttccgg cagcggctcc      660

ggcaccgact tcaccctgac catcagctcc ctggaacccg aggactttgc catgtactat      720

tgccagcagc acaacaagta cccttacacc ttcggcggag gcaccaagct ggaaatcaag      780

gccagctccg gagagagcaa gtacggccct ccctgccccc cttgccctgc ccccgagttc      840

ctgggcggac ccagcgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc      900

cggacccccg aggtgacctg tgtggtggtg gacgtgtccc aggaggaccc cgaggtccag      960

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggag     1020

cagttcaata gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg     1080

aacggcaagg aatacaagtg taaggtgtcc aacaagggcc tgcccagcag catcgagaaa     1140

accatcagca aggccaaggg ccagcctcgg gagccccagg tgtacaccct gccccctagc     1200

caagaggaga tgaccaagaa ccaggtgtcc ctgacctgcc tggtgaaggg cttctacccc     1260

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     1320

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gccggctgac cgtggacaag     1380

agccggtggc aggagggcaa cgtctttagc tgctccgtga tgcacgaggc cctgcacaac     1440

cactacaccc agaagagcct gagcctgtcc ctgggcaaga tggatatcta catctgggcg     1500

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1560

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1620

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1680

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1740

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1800

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1860

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1920

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1980

acctacgacg cccttcacat gcaggccctg ccccctcgc                            2019


<210> 97
<211> 673
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 97
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
            20                  25                  30          


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
    50                  55                  60                  


Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu 
65                  70                  75                  80  


Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp 
                85                  90                  95      


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ser Gly Gly Gly Ser Asp Val Gln Ile Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys 
                165                 170                 175     


Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys 
            180                 185                 190         


Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln 
        195                 200                 205             


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Ala Ser Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Asp Ile 
                485                 490                 495     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            500                 505                 510         


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        515                 520                 525             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    530                 535                 540                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
545                 550                 555                 560 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                565                 570                 575     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            580                 585                 590         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        595                 600                 605             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    610                 615                 620                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
625                 630                 635                 640 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                645                 650                 655     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            660                 665                 670         


Arg 
    


<210> 98
<211> 112
<212> PRT
<213> Homo sapiens

<400> 98
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 99
<211> 336
<212> DNA
<213> Homo sapiens

<400> 99
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210> 100
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 100
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser 
            20                  25                  30          


Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala 
        35                  40                  45              


Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly 
    50                  55                  60                  


Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly 
65                  70                  75                  80  


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln 
            100                 105                 110         


Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly 
145                 150                 155                 160 


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
                165                 170                 175     


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                245                 250                 255     


Thr Val Ser Ser Ala Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210> 101
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 101
Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys 
145                 150                 155                 160 


Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
                165                 170                 175     


Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn Trp Asp 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235         


<210> 102
<211> 1461
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 102
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cccggatccg acgtgcagat cacacagagc cctagctacc tggccgccag ccctggcgag      120

acaatcacca tcaactgccg ggccagcaag agcatcagca aggacctggc ctggtatcag      180

gaaaagcccg gcaagaccaa caagctgctg atctacagcg gcagcaccct gcagagcggc      240

atccccagca gattttccgg cagcggctcc ggcaccgact tcaccctgac aatcagcagc      300

ctggaacccg aggacttcgc catgtactac tgccagcagc acaacaagta cccctacacc      360

ttcggcggag gcaccaagct ggaaatcaag ggcggaggcg gatctggcgg cggaggaagt      420

tctggcggag gatctcaggt gcagctgcag cagccaggcg ctgaactcgt gcggcctggc      480

gcttctgtga agctgagctg taaagccagc ggctacacct ttaccagcta ctggatgaac      540

tgggtcaagc agcggcccga ccagggcctg gagtggatcg gcagaatcga cccctacgac      600

agcgagacac actacaacca gaagttcaag gacaaggcca tcctgaccgt ggacaagagc      660

agctccaccg cctacatgca gctgtccagc ctgaccagcg aggacagcgc cgtgtactat      720

tgcgccaggg gcaactggga cgactactgg ggccagggca caaccctgac agtgtcctct      780

gctagctccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210> 103
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 103
gacgtgcaga tcacacagag ccctagctac ctggccgcca gccctggcga gacaatcacc       60

atcaactgcc gggccagcaa gagcatcagc aaggacctgg cctggtatca ggaaaagccc      120

ggcaagacca acaagctgct gatctacagc ggcagcaccc tgcagagcgg catccccagc      180

agattttccg gcagcggctc cggcaccgac ttcaccctga caatcagcag cctggaaccc      240

gaggacttcg ccatgtacta ctgccagcag cacaacaagt acccctacac cttcggcgga      300

ggcaccaagc tggaaatcaa gggcggaggc ggatctggcg gcggaggaag ttctggcgga      360

ggatctcagg tgcagctgca gcagccaggc gctgaactcg tgcggcctgg cgcttctgtg      420

aagctgagct gtaaagccag cggctacacc tttaccagct actggatgaa ctgggtcaag      480

cagcggcccg accagggcct ggagtggatc ggcagaatcg acccctacga cagcgagaca      540

cactacaacc agaagttcaa ggacaaggcc atcctgaccg tggacaagag cagctccacc      600

gcctacatgc agctgtccag cctgaccagc gaggacagcg ccgtgtacta ttgcgccagg      660

ggcaactggg acgactactg gggccagggc acaaccctga cagtgtcctc t               711


<210> 104
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 104
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210> 105
<211> 690
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 105
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggaccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag      120

gtgacctgtg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt caactggtac      180

gtggacggcg tggaggtgca caacgccaag accaagcccc gggaggagca gttcaatagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      300

tacaagtgta aggtgtccaa caagggcctg cccagcagca tcgagaaaac catcagcaag      360

gccaagggcc agcctcggga gccccaggtg tacaccctgc cccctagcca agaggagatg      420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      540

gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag      600

gagggcaacg tctttagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgtccct gggcaagatg                                       690


<210> 106
<211> 2684
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 106
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccactgagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgtgcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtgagctagc tctagagcca     1200

ccatggccct gcctgtgaca gccctgctgc tgcctctggc tctgctgctg catgccgcta     1260

gacccggatc cgacatcgtg ctgacacaga gccctgcttc cctggccgtg tccctgggac     1320

agagagccac aatcagctgc agggccagcg agagcgtgga caactacggc aacaccttca     1380

tgcactggta tcagcagaag cccggccagc cccccaagct gctgatctac agagccagca     1440

acctggaaag cggcatcccc gccagatttt ccggcagcgg cagcagaacc gacttcaccc     1500

tgaccatcaa ccccgtggaa gccgacgacg tggccaccta ctactgccag cagagcaacg     1560

aggacccccc cacatttgga gccggcacca agctggaact gaagggcgga ggcggatctg     1620

gcggcggagg atcttctggg ggaggctctc agattcagct ggtgcagagc ggcccagagc     1680

tgaagaaacc cggcgagaca gtgaagatct cctgcaaggc ctccggctac atcttcacca     1740

attacggcat gaactgggtc aagcaggccc ctggcaagag cttcaagtgg atgggctgga     1800

tcaacaccta caccggcgag agcacctaca gcgccgactt caagggcaga ttcgccttca     1860

gcctggaaac cagcgccagc accgcctacc tgcacatcaa cgacctgaag aacgaggaca     1920

ccgccaccta tttctgcgcc agaagcggcg gctacgaccc catggattat tggggccagg     1980

gcaccagcgt gaccgtgtcc tctgctagct ccggaaccac gacgccagcg ccgcgaccac     2040

caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc     2100

cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat atctacatct     2160

gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc accctttact     2220

gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg agaccagtac     2280

aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa gaaggaggat     2340

gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag cagggccaga     2400

accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga     2460

gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc     2520

tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag     2580

gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca     2640

aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc                      2684


<210> 107
<211> 494
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 107
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn 
65                  70                  75                  80  


Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
            180                 185                 190         


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
        195                 200                 205             


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
    210                 215                 220                 


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ser Gly Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210> 108
<211> 1482
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 108
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acatcgtgct gacacagagc cctgcttccc tggccgtgtc cctgggacag      120

agagccacaa tcagctgcag ggccagcgag agcgtggaca actacggcaa caccttcatg      180

cactggtatc agcagaagcc cggccagccc cccaagctgc tgatctacag agccagcaac      240

ctggaaagcg gcatccccgc cagattttcc ggcagcggca gcagaaccga cttcaccctg      300

accatcaacc ccgtggaagc cgacgacgtg gccacctact actgccagca gagcaacgag      360

gaccccccca catttggagc cggcaccaag ctggaactga agggcggagg cggatctggc      420

ggcggaggat cttctggggg aggctctcag attcagctgg tgcagagcgg cccagagctg      480

aagaaacccg gcgagacagt gaagatctcc tgcaaggcct ccggctacat cttcaccaat      540

tacggcatga actgggtcaa gcaggcccct ggcaagagct tcaagtggat gggctggatc      600

aacacctaca ccggcgagag cacctacagc gccgacttca agggcagatt cgccttcagc      660

ctggaaacca gcgccagcac cgcctacctg cacatcaacg acctgaagaa cgaggacacc      720

gccacctatt tctgcgccag aagcggcggc tacgacccca tggattattg gggccagggc      780

accagcgtga ccgtgtcctc tgctagctcc ggaaccacga cgccagcgcc gcgaccacca      840

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      900

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg      960

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     1020

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1080

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1140

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac     1200

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1260

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1320

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1380

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1440

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                        1482


<210> 109
<211> 680
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 109
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn 
65                  70                  75                  80  


Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
            180                 185                 190         


Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr 
        195                 200                 205             


Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
    210                 215                 220                 


Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ser Gly Glu 
            260                 265                 270         


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Leu Gly Lys Met Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            500                 505                 510         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
        515                 520                 525             


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    530                 535                 540                 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
545                 550                 555                 560 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                565                 570                 575     


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            580                 585                 590         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        595                 600                 605             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    610                 615                 620                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
625                 630                 635                 640 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                645                 650                 655     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            660                 665                 670         


His Met Gln Ala Leu Pro Pro Arg 
        675                 680 


<210> 110
<211> 2040
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 110
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acatcgtgct gacacagagc cctgcttccc tggccgtgtc cctgggacag      120

agagccacaa tcagctgcag ggccagcgag agcgtggaca actacggcaa caccttcatg      180

cactggtatc agcagaagcc cggccagccc cccaagctgc tgatctacag agccagcaac      240

ctggaaagcg gcatccccgc cagattttcc ggcagcggca gcagaaccga cttcaccctg      300

accatcaacc ccgtggaagc cgacgacgtg gccacctact actgccagca gagcaacgag      360

gaccccccca catttggagc cggcaccaag ctggaactga agggcggagg cggatctggc      420

ggcggaggat cttctggggg aggctctcag attcagctgg tgcagagcgg cccagagctg      480

aagaaacccg gcgagacagt gaagatctcc tgcaaggcct ccggctacat cttcaccaat      540

tacggcatga actgggtcaa gcaggcccct ggcaagagct tcaagtggat gggctggatc      600

aacacctaca ccggcgagag cacctacagc gccgacttca agggcagatt cgccttcagc      660

ctggaaacca gcgccagcac cgcctacctg cacatcaacg acctgaagaa cgaggacacc      720

gccacctatt tctgcgccag aagcggcggc tacgacccca tggattattg gggccagggc      780

accagcgtga ccgtgtcctc tgctagctcc ggagagagca agtacggccc tccctgcccc      840

ccttgccctg cccccgagtt cctgggcgga cccagcgtgt tcctgttccc ccccaagccc      900

aaggacaccc tgatgatcag ccggaccccc gaggtgacct gtgtggtggt ggacgtgtcc      960

caggaggacc ccgaggtcca gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc     1020

aagaccaagc cccgggagga gcagttcaat agcacctacc gggtggtgtc cgtgctgacc     1080

gtgctgcacc aggactggct gaacggcaag gaatacaagt gtaaggtgtc caacaagggc     1140

ctgcccagca gcatcgagaa aaccatcagc aaggccaagg gccagcctcg ggagccccag     1200

gtgtacaccc tgccccctag ccaagaggag atgaccaaga accaggtgtc cctgacctgc     1260

ctggtgaagg gcttctaccc cagcgacatc gccgtggagt gggagagcaa cggccagccc     1320

gagaacaact acaagaccac cccccctgtg ctggacagcg acggcagctt cttcctgtac     1380

agccggctga ccgtggacaa gagccggtgg caggagggca acgtctttag ctgctccgtg     1440

atgcacgagg ccctgcacaa ccactacacc cagaagagcc tgagcctgtc cctgggcaag     1500

atggatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg     1560

gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca     1620

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1680

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg     1740

tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1800

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     1860

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     1920

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     1980

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     2040


<210> 111
<211> 494
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 111
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro 
            20                  25                  30          


Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro 
    50                  55                  60                  


Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu 
65                  70                  75                  80  


Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu 
                85                  90                  95      


Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu 
            100                 105                 110         


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe 
            180                 185                 190         


Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala 
225                 230                 235                 240 


Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Ser Gly Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210> 112
<211> 1482
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 112
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccc agatccagct ggtgcagtct ggccccgagc tgaagaaacc cggcgagaca      120

gtgaagatca gctgcaaggc cagcggctac atcttcacca actacggcat gaactgggtc      180

aagcaggccc ctggcaagag cttcaagtgg atgggctgga tcaacaccta caccggcgag      240

agcacctaca gcgccgactt caagggcaga ttcgccttca gcctggaaac cagcgccagc      300

accgcctacc tgcacatcaa cgacctgaag aacgaggaca ccgccaccta cttttgcgcc      360

agaagcggcg gctacgaccc catggattat tggggccagg gcaccagcgt gaccgtgtct      420

agcggaggcg gaggatctgg cggaggggga tcttctggcg gcggaagcga tatcgtgctg      480

acccagtctc ctgccagcct ggccgtgtct ctgggacaga gagccacaat cagctgccgg      540

gcctctgaga gcgtggacaa ttacggcaac accttcatgc actggtatca gcagaagccc      600

ggccagcccc ccaagctgct gatctacaga gccagcaacc tggaaagcgg catccccgcc      660

agattttccg gcagcggcag cagaaccgac ttcaccctga ccatcaaccc cgtggaagcc      720

gacgacgtgg ccacctatta ctgccagcag agcaacgagg acccccctac ctttggagcc      780

ggcaccaagc tggaactgaa ggctagctcc ggaaccacga cgccagcgcc gcgaccacca      840

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      900

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg      960

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     1020

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1080

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1140

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac     1200

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1260

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1320

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1380

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1440

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                        1482


<210> 113
<211> 680
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 113
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro 
            20                  25                  30          


Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro 
    50                  55                  60                  


Gly Lys Ser Phe Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu 
65                  70                  75                  80  


Ser Thr Tyr Ser Ala Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu 
                85                  90                  95      


Thr Ser Ala Ser Thr Ala Tyr Leu His Ile Asn Asp Leu Lys Asn Glu 
            100                 105                 110         


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Gly Gly Tyr Asp Pro Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Asn Thr Phe 
            180                 185                 190         


Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala 
225                 230                 235                 240 


Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Pro 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Ser Gly Glu 
            260                 265                 270         


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Leu Gly Lys Met Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            500                 505                 510         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
        515                 520                 525             


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    530                 535                 540                 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
545                 550                 555                 560 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                565                 570                 575     


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            580                 585                 590         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        595                 600                 605             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    610                 615                 620                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
625                 630                 635                 640 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                645                 650                 655     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            660                 665                 670         


His Met Gln Ala Leu Pro Pro Arg 
        675                 680 


<210> 114
<211> 2040
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 114
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccc agatccagct ggtgcagtct ggccccgagc tgaagaaacc cggcgagaca      120

gtgaagatca gctgcaaggc cagcggctac atcttcacca actacggcat gaactgggtc      180

aagcaggccc ctggcaagag cttcaagtgg atgggctgga tcaacaccta caccggcgag      240

agcacctaca gcgccgactt caagggcaga ttcgccttca gcctggaaac cagcgccagc      300

accgcctacc tgcacatcaa cgacctgaag aacgaggaca ccgccaccta cttttgcgcc      360

agaagcggcg gctacgaccc catggattat tggggccagg gcaccagcgt gaccgtgtct      420

agcggaggcg gaggatctgg cggaggggga tcttctggcg gcggaagcga tatcgtgctg      480

acccagtctc ctgccagcct ggccgtgtct ctgggacaga gagccacaat cagctgccgg      540

gcctctgaga gcgtggacaa ttacggcaac accttcatgc actggtatca gcagaagccc      600

ggccagcccc ccaagctgct gatctacaga gccagcaacc tggaaagcgg catccccgcc      660

agattttccg gcagcggcag cagaaccgac ttcaccctga ccatcaaccc cgtggaagcc      720

gacgacgtgg ccacctatta ctgccagcag agcaacgagg acccccctac ctttggagcc      780

ggcaccaagc tggaactgaa ggctagctcc ggagagagca agtacggccc tccctgcccc      840

ccttgccctg cccccgagtt cctgggcgga cccagcgtgt tcctgttccc ccccaagccc      900

aaggacaccc tgatgatcag ccggaccccc gaggtgacct gtgtggtggt ggacgtgtcc      960

caggaggacc ccgaggtcca gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc     1020

aagaccaagc cccgggagga gcagttcaat agcacctacc gggtggtgtc cgtgctgacc     1080

gtgctgcacc aggactggct gaacggcaag gaatacaagt gtaaggtgtc caacaagggc     1140

ctgcccagca gcatcgagaa aaccatcagc aaggccaagg gccagcctcg ggagccccag     1200

gtgtacaccc tgccccctag ccaagaggag atgaccaaga accaggtgtc cctgacctgc     1260

ctggtgaagg gcttctaccc cagcgacatc gccgtggagt gggagagcaa cggccagccc     1320

gagaacaact acaagaccac cccccctgtg ctggacagcg acggcagctt cttcctgtac     1380

agccggctga ccgtggacaa gagccggtgg caggagggca acgtctttag ctgctccgtg     1440

atgcacgagg ccctgcacaa ccactacacc cagaagagcc tgagcctgtc cctgggcaag     1500

atggatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg     1560

gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca     1620

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1680

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg     1740

tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1800

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     1860

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     1920

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     1980

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     2040


<210> 115
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 115
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser 
            20                  25                  30          


Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala 
        35                  40                  45              


Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly 
    50                  55                  60                  


Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly 
65                  70                  75                  80  


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln 
            100                 105                 110         


Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly 
145                 150                 155                 160 


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
                165                 170                 175     


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                245                 250                 255     


Thr Val Ser Ser Ala Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210> 116
<211> 1461
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 116
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cccggatccg acgtgcagat cacacagagc cctagctacc tggccgccag ccctggcgag      120

acaatcacca tcaactgccg ggccagcaag agcatcagca aggacctggc ctggtatcag      180

gaaaagcccg gcaagaccaa caagctgctg atctacagcg gcagcaccct gcagagcggc      240

atccccagca gattttccgg cagcggctcc ggcaccgact tcaccctgac aatcagcagc      300

ctggaacccg aggacttcgc catgtactac tgccagcagc acaacaagta cccctacacc      360

ttcggcggag gcaccaagct ggaaatcaag ggcggaggcg gatctggcgg cggaggaagt      420

tctggcggag gatctcaggt gcagctgcag cagccaggcg ctgaactcgt gcggcctggc      480

gcttctgtga agctgagctg taaagccagc ggctacacct ttaccagcta ctggatgaac      540

tgggtcaagc agcggcccga ccagggcctg gagtggatcg gcagaatcga cccctacgac      600

agcgagacac actacaacca gaagttcaag gacaaggcca tcctgaccgt ggacaagagc      660

agctccaccg cctacatgca gctgtccagc ctgaccagcg aggacagcgc cgtgtactat      720

tgcgccaggg gcaactggga cgactactgg ggccagggca caaccctgac agtgtcctct      780

gctagctccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210> 117
<211> 673
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 117
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser 
            20                  25                  30          


Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala 
        35                  40                  45              


Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly 
    50                  55                  60                  


Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly 
65                  70                  75                  80  


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln 
            100                 105                 110         


Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly 
145                 150                 155                 160 


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
                165                 170                 175     


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                245                 250                 255     


Thr Val Ser Ser Ala Ser Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Asp Ile 
                485                 490                 495     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            500                 505                 510         


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        515                 520                 525             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    530                 535                 540                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
545                 550                 555                 560 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                565                 570                 575     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            580                 585                 590         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        595                 600                 605             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    610                 615                 620                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
625                 630                 635                 640 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                645                 650                 655     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            660                 665                 670         


Arg 
    


<210> 118
<211> 2019
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 118
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cccggatccg acgtgcagat cacacagagc cctagctacc tggccgccag ccctggcgag      120

acaatcacca tcaactgccg ggccagcaag agcatcagca aggacctggc ctggtatcag      180

gaaaagcccg gcaagaccaa caagctgctg atctacagcg gcagcaccct gcagagcggc      240

atccccagca gattttccgg cagcggctcc ggcaccgact tcaccctgac aatcagcagc      300

ctggaacccg aggacttcgc catgtactac tgccagcagc acaacaagta cccctacacc      360

ttcggcggag gcaccaagct ggaaatcaag ggcggaggcg gatctggcgg cggaggaagt      420

tctggcggag gatctcaggt gcagctgcag cagccaggcg ctgaactcgt gcggcctggc      480

gcttctgtga agctgagctg taaagccagc ggctacacct ttaccagcta ctggatgaac      540

tgggtcaagc agcggcccga ccagggcctg gagtggatcg gcagaatcga cccctacgac      600

agcgagacac actacaacca gaagttcaag gacaaggcca tcctgaccgt ggacaagagc      660

agctccaccg cctacatgca gctgtccagc ctgaccagcg aggacagcgc cgtgtactat      720

tgcgccaggg gcaactggga cgactactgg ggccagggca caaccctgac agtgtcctct      780

gctagctccg gagagagcaa gtacggccct ccctgccccc cttgccctgc ccccgagttc      840

ctgggcggac ccagcgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc      900

cggacccccg aggtgacctg tgtggtggtg gacgtgtccc aggaggaccc cgaggtccag      960

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggag     1020

cagttcaata gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg     1080

aacggcaagg aatacaagtg taaggtgtcc aacaagggcc tgcccagcag catcgagaaa     1140

accatcagca aggccaaggg ccagcctcgg gagccccagg tgtacaccct gccccctagc     1200

caagaggaga tgaccaagaa ccaggtgtcc ctgacctgcc tggtgaaggg cttctacccc     1260

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     1320

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gccggctgac cgtggacaag     1380

agccggtggc aggagggcaa cgtctttagc tgctccgtga tgcacgaggc cctgcacaac     1440

cactacaccc agaagagcct gagcctgtcc ctgggcaaga tggatatcta catctgggcg     1500

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1560

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1620

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1680

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1740

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1800

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1860

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1920

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1980

acctacgacg cccttcacat gcaggccctg ccccctcgc                            2019


<210> 119
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 119
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
            20                  25                  30          


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
    50                  55                  60                  


Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu 
65                  70                  75                  80  


Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp 
                85                  90                  95      


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ser Gly Gly Gly Ser Asp Val Gln Ile Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys 
                165                 170                 175     


Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys 
            180                 185                 190         


Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln 
        195                 200                 205             


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Ala Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210> 120
<211> 1461
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 120
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cctggatccc aggtgcagct gcagcagcct ggcgctgaac tcgtgcggcc aggcgcttct      120

gtgaagctga gctgtaaagc cagcggctac accttcacca gctactggat gaactgggtc      180

aagcagcggc ccgaccaggg cctggagtgg atcggcagaa tcgaccccta cgacagcgag      240

acacactaca accagaagtt caaggacaag gccatcctga ccgtggacaa gagcagcagc      300

accgcctaca tgcagctgtc cagcctgacc agcgaggaca gcgccgtgta ctactgcgcc      360

aggggcaact gggacgacta ttggggccag ggcaccaccc tgacagtgtc tagcggaggc      420

ggaggatctg gcggcggagg aagttctggc ggaggctccg acgtgcagat cacccagagc      480

cctagctacc tggccgcctc tcctggcgag acaatcacca tcaactgccg ggccagcaag      540

agcatctcca aggacctggc ctggtatcag gaaaagcccg gcaagaccaa caagctgctg      600

atctacagcg gcagcaccct gcagagcggc atccccagca gattttccgg cagcggctcc      660

ggcaccgact tcaccctgac catcagctcc ctggaacccg aggactttgc catgtactat      720

tgccagcagc acaacaagta cccttacacc ttcggcggag gcaccaagct ggaaatcaag      780

gccagctccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210> 121
<211> 673
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 121
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
            20                  25                  30          


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
    50                  55                  60                  


Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu 
65                  70                  75                  80  


Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp 
                85                  90                  95      


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ser Gly Gly Gly Ser Asp Val Gln Ile Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys 
                165                 170                 175     


Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys 
            180                 185                 190         


Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln 
        195                 200                 205             


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Ala Ser Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Asp Ile 
                485                 490                 495     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            500                 505                 510         


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        515                 520                 525             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    530                 535                 540                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
545                 550                 555                 560 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                565                 570                 575     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            580                 585                 590         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        595                 600                 605             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    610                 615                 620                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
625                 630                 635                 640 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                645                 650                 655     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            660                 665                 670         


Arg 
    


<210> 122
<211> 282
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 122
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210> 123
<211> 847
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 123
aggtggcccg aaagtcccaa ggcccaggca tctagtgttc ctactgcaca gccccaggca       60

gaaggcagcc tagccaaagc tactactgca cctgccacta cgcgcaatac tggccgtggc      120

ggggaggaga agaaaaagga gaaagagaaa gaagaacagg aagagaggga gaccaagacc      180

cctgaatgtc catcccatac ccagccgctg ggcgtctatc tcttgactcc cgcagtacag      240

gacttgtggc ttagagataa ggccaccttt acatgtttcg tcgtgggctc tgacctgaag      300

gatgcccatt tgacttggga ggttgccgga aaggtaccca cagggggggt tgaggaaggg      360

ttgctggagc gccattccaa tggctctcag agccagcact caagactcac ccttccgaga      420

tccctgtgga acgccgggac ctctgtcaca tgtactctaa atcatcctag cctgccccca      480

cagcgtctga tggcccttag agagccagcc gcccaggcac cagttaagct tagcctgaat      540

ctgctcgcca gtagtgatcc cccagaggcc gccagctggc tcttatgcga agtgtccggc      600

tttagcccgc ccaacatctt gctcatgtgg ctggaggacc agcgagaagt gaacaccagc      660

ggcttcgctc cagcccggcc cccaccccag ccgggttcta ccacattctg ggcctggagt      720

gtcttaaggg tcccagcacc acctagcccc cagccagcca catacacctg tgttgtgtcc      780

catgaagata gcaggaccct gctaaatgct tctaggagtc tggaggtttc ctacgtgact      840

gaccatt                                                                847


<210> 124
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 124
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 125
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 125
ggtggcggag gttctggagg tggaggttcc                                        30


<210> 126
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> misc_feature
<222> (1)..(30) 
<223> /note="This sequence may encompass 1, 2, 3, 4, 5, or 6
      'Gly Gly Gly Gly Ser' repeating units"

<220>
<221> VARIANT
<222> (6)..(30) 
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(30) 
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> misc_feature
<222> (1)..(30) 
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 126
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 127
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 127
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                       150


<210> 128
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 128
His His His His His His 
1               5       


<210> 129
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 129
Gly Gly Gly Ser 
1               


<210> 130
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 130
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 131
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 131
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 132
<211> 5000
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(5000) 
<223> /note="This sequence may encompass between 50 and 5,000 
      nucleotides"

<220>
<221> variation
<222> (51)..(5000) 
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(5000) 
<223> /note="Variant bases given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> misc_feature
<222> (1)..(5000) 
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 132
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2460

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2520

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2580

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2700

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2760

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2820

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3060

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3600

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4980

aaaaaaaaaa aaaaaaaaaa                                                 5000


<210> 133
<211> 2000
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(2000) 
<223> /note="This sequence may encompass between 50 and 2,000 
      nucleotides"

<220>
<221> variation
<222> (51)..(2000) 
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(2000) 
<223> /note="Variant bases given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 133
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaaa                                                 2000


<210> 134
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 134
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt tttttttttt tttttttttt                            100


<210> 135
<211> 5000
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(5000) 
<223> /note="This sequence may encompass between 50 and 5,000 
      nucleotides"

<220>
<221> variation
<222> (51)..(5000) 
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(5000) 
<223> /note="Variant bases given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 135
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      120

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      180

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      240

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      300

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      360

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      420

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      480

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      540

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      600

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      660

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      720

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      780

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      840

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      900

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      960

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1020

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1080

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1140

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1200

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1260

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1320

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1380

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1440

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1500

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1560

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1620

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1680

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1740

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1800

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1860

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1920

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     1980

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2040

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2100

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2160

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2220

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2280

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2340

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2400

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2460

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2520

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2580

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2640

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2700

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2760

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2820

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2880

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     2940

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3000

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3060

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3120

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3180

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3240

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3300

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3360

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3420

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3480

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3540

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3600

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3660

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3720

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3780

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3840

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3900

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     3960

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4020

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4080

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4140

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4200

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4260

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4320

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4380

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4440

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4500

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4560

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4620

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4680

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4740

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4800

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4860

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4920

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     4980

tttttttttt tttttttttt                                                 5000


<210> 136
<211> 5000
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(5000) 
<223> /note="This sequence may encompass between 100 and 5,000 
      nucleotides"

<220>
<221> variation
<222> (101)..(5000) 
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(5000) 
<223> /note="Variant bases given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 136
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      600

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2460

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2520

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2580

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2700

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2760

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2820

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3060

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3600

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4980

aaaaaaaaaa aaaaaaaaaa                                                 5000


