                         SEQUENCE LISTING

<110>  Oxford BioTherpeutics
 
<120>  THERAPEUTIC AND DIAGNOSTIC TARGET

<130>  OB00069

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Glu Asn Glu Ala Ser Leu Pro Asn Thr Ser Leu Gln Gly Lys 
1               5                   10                  15      


Lys Met Ala Tyr Gln Lys Val His Ala Asp Gln Arg Ala Pro Gly His 
            20                  25                  30          


Ser Gln Tyr Leu Asp Asn Asp Asp Leu Gln Ala Thr Ala Leu Asp Leu 
        35                  40                  45              


Glu Trp Asp Met Glu Lys Glu Leu Glu Glu Ser Gly Phe Asp Gln Phe 
    50                  55                  60                  


Gln Leu Asp Gly Ala Glu Asn Gln Asn Leu Gly His Ser Glu Thr Ile 
65                  70                  75                  80  


Asp Leu Asn Leu Asp Ser Ile Gln Pro Ala Thr Ser Pro Lys Gly Arg 
                85                  90                  95      


Phe Gln Arg Leu Gln Glu Glu Ser Asp Tyr Ile Thr His Tyr Thr Arg 
            100                 105                 110         


Ser Ala Pro Lys Ser Asn Arg Cys Asn Phe Cys His Val Leu Lys Ile 
        115                 120                 125             


Leu Cys Thr Ala Thr Ile Leu Phe Ile Phe Gly Ile Leu Ile Gly Tyr 
    130                 135                 140                 


Tyr Val His Thr Asn Cys Pro Ser Asp Ala Pro Ser Ser Gly Thr Val 
145                 150                 155                 160 


Asp Pro Gln Leu Tyr Gln Glu Ile Leu Lys Thr Ile Gln Ala Glu Asp 
                165                 170                 175     


Ile Lys Lys Ser Phe Arg Asn Leu Val Gln Leu Tyr Lys Asn Glu Asp 
            180                 185                 190         


Asp Met Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser Leu Gly 
        195                 200                 205             


Leu Glu Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp Leu Pro 
    210                 215                 220                 


Gly Pro Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln Cys Phe 
225                 230                 235                 240 


His Pro Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp Ser Ser 
                245                 250                 255     


Gln Asp Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly Thr Leu 
            260                 265                 270         


Lys Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys 
        275                 280                 285             


Arg Ile Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu Leu Lys 
    290                 295                 300                 


Leu Gly Lys Leu Pro Leu Leu Tyr Lys Leu Ser Ser Leu Glu Lys Ala 
305                 310                 315                 320 


Gly Phe Gly Gly Val Leu Leu Tyr Ile Asp Pro Cys Asp Leu Pro Lys 
                325                 330                 335     


Thr Val Asn Pro Ser His Asp Thr Phe Met Val Ser Leu Asn Pro Gly 
            340                 345                 350         


Gly Asp Pro Ser Thr Pro Gly Tyr Pro Ser Val Asp Glu Ser Phe Arg 
        355                 360                 365             


Gln Ser Arg Ser Asn Leu Thr Ser Leu Leu Val Gln Pro Ile Ser Ala 
    370                 375                 380                 


Pro Leu Val Ala Lys Leu Ile Ser Ser Pro Lys Ala Arg Thr Lys Asn 
385                 390                 395                 400 


Glu Ala Cys Ser Ser Leu Glu Leu Pro Asn Asn Glu Ile Arg Val Val 
                405                 410                 415     


Ser Met Gln Val Gln Thr Val Thr Lys Leu Lys Thr Val Thr Asn Val 
            420                 425                 430         


Val Gly Phe Val Met Gly Leu Thr Ser Pro Asp Arg Tyr Ile Ile Val 
        435                 440                 445             


Gly Ser His His His Thr Ala His Ser Tyr Asn Gly Gln Glu Trp Ala 
    450                 455                 460                 


Ser Ser Thr Ala Ile Ile Thr Ala Phe Ile Arg Ala Leu Met Ser Lys 
465                 470                 475                 480 


Val Lys Arg Gly Trp Arg Pro Asp Arg Thr Ile Val Phe Cys Ser Trp 
                485                 490                 495     


Gly Gly Thr Ala Phe Gly Asn Ile Gly Ser Tyr Glu Trp Gly Glu Asp 
            500                 505                 510         


Phe Lys Lys Val Leu Gln Lys Asn Val Val Ala Tyr Ile Ser Leu His 
        515                 520                 525             


Ser Pro Ile Arg Gly Asn Ser Ser Leu Tyr Pro Val Ala Ser Pro Ser 
    530                 535                 540                 


Leu Gln Gln Leu Val Val Glu Lys Asn Asn Phe Asn Cys Thr Arg Arg 
545                 550                 555                 560 


Ala Gln Cys Pro Glu Thr Asn Ile Ser Ser Ile Gln Ile Gln Gly Asp 
                565                 570                 575     


Ala Asp Tyr Phe Ile Asn His Leu Gly Val Pro Ile Val Gln Phe Ala 
            580                 585                 590         


Tyr Glu Asp Ile Lys Thr Leu Glu Gly Pro Ser Phe Leu Ser Glu Ala 
        595                 600                 605             


Arg Phe Ser Thr Arg Ala Thr Lys Ile Glu Glu Met Asp Pro Ser Phe 
    610                 615                 620                 


Asn Leu His Glu Thr Ile Thr Lys Leu Ser Gly Glu Val Ile Leu Gln 
625                 630                 635                 640 


Ile Ala Asn Glu Pro Val Leu Pro Phe Asn Ala Leu Asp Ile Ala Leu 
                645                 650                 655     


Glu Val Gln Asn Asn Leu Lys Gly Asp Gln Pro Asn Thr His Gln Leu 
            660                 665                 670         


Leu Ala Met Ala Leu Arg Leu Arg Glu Ser Ala Glu Leu Phe Gln Ser 
        675                 680                 685             


Asp Glu Met Arg Pro Ala Asn Asp Pro Lys Glu Arg Ala Pro Ile Arg 
    690                 695                 700                 


Ile Arg Met Leu Asn Asp Ile Leu Gln Asp Met Glu Lys Ser Phe Leu 
705                 710                 715                 720 


Val Lys Gln Ala Pro Pro Gly Phe Tyr Arg Asn Ile Leu Tyr His Leu 
                725                 730                 735     


Asp Glu Lys Thr Ser Arg Phe Ser Ile Leu Ile Glu Ala Trp Glu His 
            740                 745                 750         


Cys Lys Pro Leu Ala Ser Asn Glu Thr Leu Gln Glu Ala Leu Ser Glu 
        755                 760                 765             


Val Leu Asn Ser Ile Asn Ser Ala Gln Val Tyr Phe Lys Ala Gly Leu 
    770                 775                 780                 


Asp Val Phe Lys Ser Val Leu Asp Gly Lys Asn 
785                 790                 795 


<210>  2
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Tyr Gln Lys Val His Ala Asp Gln Arg Ala Pro Gly His Ser 
1               5                   10                  15      


Gln Tyr Leu Asp Asn Asp Asp Leu Gln Ala Thr Ala Leu Asp Leu Glu 
            20                  25                  30          


Trp Asp Met Glu Lys Glu Leu Glu Glu Ser Gly Phe Asp Gln Phe Gln 
        35                  40                  45              


Leu Asp Gly Ala Glu Asn Gln Asn Leu Gly His Ser Glu Thr Ile Asp 
    50                  55                  60                  


Leu Asn Leu Asp Ser Ile Gln Pro Ala Thr Ser Pro Lys Gly Arg Phe 
65                  70                  75                  80  


Gln Arg Leu Gln Glu Glu Ser Asp Tyr Ile Thr His Tyr Thr Arg Ser 
                85                  90                  95      


Ala Pro Lys Ser Asn Arg Cys Asn Phe Cys His Val Leu Lys Ile Leu 
            100                 105                 110         


Cys Thr Ala Thr Ile Leu Phe Ile Phe Gly Ile Leu Ile Gly Tyr Tyr 
        115                 120                 125             


Val His Thr Asn Cys Pro Ser Asp Ala Pro Ser Ser Gly Thr Val Asp 
    130                 135                 140                 


Pro Gln Leu Tyr Gln Glu Ile Leu Lys Thr Ile Gln Ala Glu Asp Ile 
145                 150                 155                 160 


Lys Lys Ser Phe Arg Asn Leu Val Gln Leu Tyr Lys Asn Glu Asp Asp 
                165                 170                 175     


Met Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser Leu Gly Leu 
            180                 185                 190         


Glu Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp Leu Pro Gly 
        195                 200                 205             


Pro Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln Cys Phe His 
    210                 215                 220                 


Pro Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp Ser Ser Gln 
225                 230                 235                 240 


Asp Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly Thr Leu Lys 
                245                 250                 255     


Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys Arg 
            260                 265                 270         


Ile Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu Leu Lys Leu 
        275                 280                 285             


Gly Lys Leu Pro Leu Leu Tyr Lys Val Gly Pro Val Asn Val Ile Gln 
    290                 295                 300                 


Trp Phe Gly Gln Tyr Phe Ala Leu Phe Cys Trp Asn Tyr Met Leu Leu 
305                 310                 315                 320 


<210>  3
<211>  4912
<212>  DNA
<213>  Homo sapiens

<400>  3
acagtagaaa gtcagaaggt cacaaagctt gcagggtaag tgacacaact tgaaactgct       60

tggccctctt taaaaagaaa taataaaatg ggagagaatg aagcaagttt acctaacacg      120

tctttgcaag gtaaaaagat ggcctatcag aaggtccatg cagatcaaag agctccagga      180

cactcacagt acttagacaa tgatgacctt caagccactg cccttgactt agagtgggac      240

atggagaagg aactagagga gtctggtttt gaccaattcc agctagacgg tgctgagaat      300

cagaacctag ggcattcaga gactatagac ctcaatcttg attccattca accagcaact      360

tcacccaaag gaaggttcca gagacttcaa gaagaatctg actacattac ccattataca      420

cgatctgcac caaagagcaa tcgctgcaac ttttgccacg tcttaaaaat actttgcaca      480

gccaccattt tatttatttt tgggattttg ataggttatt atgtacatac aaattgccct      540

tcagatgctc catcttcagg aacagttgat cctcagttat atcaagagat tctcaagaca      600

atccaggcag aagatattaa gaagtctttc agaaatttgg tacaactata taaaaatgaa      660

gatgacatgg aaatttcaaa gaagattaag actcagtgga cctctttggg cctagaagat      720

gtacagtttg taaattactc tgtgctgctt gatctgccag gcccttctcc cagcactgtg      780

actctgagca gcagtggtca atgctttcat cctaatggcc agccttgcag tgaagaagcc      840

agaaaagata gcagccaaga cctgctctat tcatatgcag cctattctgc caaaggaact      900

ctcaaggctg aagtcatcga tgtgagttat ggaatggcag atgatttaaa aaggattagg      960

aaaataaaaa acgtaacaaa tcagatcgca ctcctgaaat taggaaaatt gccactgctt     1020

tataagcttt cctcattgga aaaggctgga tttggaggtg ttcttctgta tatcgatcct     1080

tgtgatttgc caaagactgt gaatcctagc catgatacct tcatggtgtc actgaatcca     1140

ggaggagacc cttctacgcc tggttaccca agtgtcgatg aaagttttag acaaagccga     1200

tcaaacctca cctctctatt agtgcagccc atctctgcac ccctcgttgc aaaactgatc     1260

tcttcgccaa aagctagaac caaaaatgaa gcgtgtagct ctctagagct tccaaataat     1320

gaaataagag tcgtcagcat gcaagttcag acagtcacaa aattgaaaac agttactaat     1380

gttgttggat ttgtaatggg cttgacatct ccagaccggt atatcatagt tggcagccat     1440

catcacactg cacacagtta taatggacaa gaatgggcca gtagtactgc aataatcaca     1500

gcgtttatcc gtgccttgat gtcaaaagtt aagagagggt ggagaccaga ccgaactatt     1560

gttttctgtt cttggggagg aacagctttt ggcaatattg gctcatatga atggggagag     1620

gatttcaaga aggttcttca gaaaaatgtt gtggcttata ttagcctcca cagtcccata     1680

agggggaact ctagtctgta tcctgtagca tcaccatctc ttcagcaact ggtagtagag     1740

aaaaataatt tcaactgtac cagaagagcc cagtgcccag aaaccaatat cagttctata     1800

cagatacaag gtgatgctga ttatttcatc aaccatcttg gagttcccat cgtgcagttt     1860

gcttacgagg acatcaaaac attagagggt ccaagttttc tctccgaggc ccgtttttct     1920

acacgagcaa caaaaattga agaaatggat ccctctttca accttcatga aaccattact     1980

aagctctcag gagaagtgat tttgcaaatt gccaacgaac ctgttctgcc ctttaatgca     2040

cttgatatag ctttagaagt tcaaaacaac cttaaaggtg atcaacccaa cactcatcaa     2100

ctgttagcca tggcgttacg cctgcgggag agtgctgaac tttttcagtc tgatgagatg     2160

cgacctgcta atgatcccaa ggagagagca cccatccgca tccggatgct gaatgacatt     2220

ctccaagaca tggagaaaag ctttctggta aagcaggcac caccaggttt ttatagaaac     2280

atcctctacc accttgatga aaagacaagc cggttttcaa tacttataga ggcttgggaa     2340

cactgcaaac cccttgcatc aaatgagacc cttcaagaag ccctgtcaga ggtgttgaac     2400

agcattaatt cagctcaggt ttacttcaaa gcaggacttg atgtgttcaa gagtgtcttg     2460

gatgggaaga attgagaaaa ctctgagcat ttttaaaagt ttgtttacaa ttccacaagc     2520

aaaagctcta atttaaccag attttctgac attgaaggct tattttcccc aatggctttt     2580

tgacaagtat aaagctatta ttacattgta ttttttaaat gtaaatatag aaagaacatt     2640

ttgcacattt aatatttttc ttatatctac atttctgaat atgtaaagca agttattgaa     2700

ataggactta agaattacct attaaaaaga aatctgatat ataaaaatat gtactatttt     2760

aaggaaaaat ttccaagaag ttctggacta tctttgttcc tatggggagg gcatatagga     2820

acacagttta ttctctctga tagagctatt aatgacttag tttctgtaaa agaaatggag     2880

agttgatatg gttcagatta acttcactat taagtgttca atatgaagaa ttcaagtatt     2940

ctgactgagt gattggttga cctaaaccac tttgaatgtt tctattttat gaaatgaagt     3000

ttctcttctt aacacaacta gatgtagtaa tacactggtt atgaaattgt atttttttaa     3060

gtattaatga aaaaagagcc ataagcattc caggagaaaa tctcaaggga gctacataga     3120

gcaatttaaa tgcaaatttt tttcctaaca acttacaagg tgactagctt tgaaacccct     3180

aatttgcctc agttgatttt ctaagaattt caggagtgat gtatgtctta agagggagaa     3240

aaaaatattt cttattactt tttctcttgt ttctgttgga aacactgaag cagggactct     3300

aaaatgaaag catctcacat tggttttctt tcttgtatct tttctgaaac tccttgctgt     3360

aaggcagctt tctcagagta ctatatattt tcaacagtaa agtagcagag tttctctttg     3420

aaacccaaaa tgtcttctaa agaatcaaat ttctatttct gcctctgaca aaaagaactt     3480

actatgaaag aaatagttgt tttatcaata aaagcccctt aatattatga agaaactttt     3540

catatttttt cttctttatc cttaattgtg actaagatgg aaatctagaa aatattcatg     3600

cttctaagtt tctgcagtgt tactgtaaga gagtgtctcg tctacacttc agttcttctc     3660

tcatgtggaa aactaagctt tttatattga cattgccatt gaatagctct agcaactatt     3720

attattcccc caaaccctaa aattctacct attaggtgtc aggttaaagt tctaatttat     3780

ctttagaaat ttatgtgaaa aatggttttc ctatactgga taaagcaatt ccccttagga     3840

aacatagcct cagagtattt catataaatt ttctctatct aattcaaaca tatctcccca     3900

tgatacaccg ccagagtgac attgcagaca gtctgtgtat gtttaaattt tcacttttta     3960

tggatgagca taaacctagt cttagtttaa aggcaaacta aagttgaggg gaaataatta     4020

atcaatactg attaattgat ttataaggtt caacactgtc taccctaaat aatttttata     4080

tgctcaaggc aaagcaggga atagaggcaa ttagctagat aattcaagca gaaatccatt     4140

ttcatcgaaa ttgcctgtgt gcacatattt ttagatgaaa aatgaaacta ccttacaata     4200

ttattttttt aaccaatgta tttgtttgca aacatttgcc atgttgaaga gtgtgtatag     4260

gaaaggtcta gaaataaata ggcttgtgca tacctaggca ttcatgctct ttcttcctct     4320

tcagagatca tcagaaaaga ggtgggaata cacaagcagg tgcatgtaag cccaaaagct     4380

agaaagcctt atatttaacc aaaggttgat gtgttcattc cagttattca cttacagatg     4440

aaactaaaac aaataaaggc aagctattat cagtttggta gttcattatt ttagaacaaa     4500

tttctaaatt aatttattcc cataacctac aatagcactg agaacagaaa acatgtttct     4560

tcttcatttt gtttaaagat tgcgtaccta ggtaagtcac actgtataga taaaaacctt     4620

cttctgtatt cctcacctct aaattatatg ttatttgcta tttgaaaact gtagttaact     4680

atggtttttt attagtctat taaaagatac gtggagatat taaattatac ctaaagcaga     4740

cgtccaacaa attctgtaca tgctgcttta catctttgca acaaacctct taactagcag     4800

cattatttct atagtgtgat tacctgaggg tgcctccaaa tgtatatcat ttcactcccc     4860

tcccctcccc acccccaata gattcaaata aataaaatcc tgagcaaatt aa             4912


<210>  4
<211>  1580
<212>  DNA
<213>  Homo sapiens

<400>  4
ggcccggcag ccgtaccgca gacgagcccg cgcccgcgcc gctcaggaaa tgagcattga       60

ctattaggca cctggatgaa gactgggtcc agattgtcag tctcctgtaa cctgcagaag      120

ccctccagtt gcactaggaa cattcaattg aagtaaaaag atggcctatc agaaggtcca      180

tgcagatcaa agagctccag gacactcaca gtacttagac aatgatgacc ttcaagccac      240

tgcccttgac ttagagtggg acatggagaa ggaactagag gagtctggtt ttgaccaatt      300

ccagctagac ggtgctgaga atcagaacct agggcattca gagactatag acctcaatct      360

tgattccatt caaccagcaa cttcacccaa aggaaggttc cagagacttc aagaagaatc      420

tgactacatt acccattata cacgatctgc accaaagagc aatcgctgca acttttgcca      480

cgtcttaaaa atactttgca cagccaccat tttatttatt tttgggattt tgataggtta      540

ttatgtacat acaaattgcc cttcagatgc tccatcttca ggaacagttg atcctcagtt      600

atatcaagag attctcaaga caatccaggc agaagatatt aagaagtctt tcagaaattt      660

ggtacaacta tataaaaatg aagatgacat ggaaatttca aagaagatta agactcagtg      720

gacctctttg ggcctagaag atgtacagtt tgtaaattac tctgtgctgc ttgatctgcc      780

aggcccttct cccagcactg tgactctgag cagcagtggt caatgctttc atcctaatgg      840

ccagccttgc agtgaagaag ccagaaaaga tagcagccaa gacctgctct attcatatgc      900

agcctattct gccaaaggaa ctctcaaggc tgaagtcatc gatgtgagtt atggaatggc      960

agatgattta aaaaggatta ggaaaataaa aaacgtaaca aatcagatcg cactcctgaa     1020

attaggaaaa ttgccactgc tttataaggt tggtccagtg aatgttattc agtggtttgg     1080

tcaatatttt gccttgtttt gttggaatta tatgcttttg tgagtgtgga gtgtgtgtgt     1140

gcatataggt gtgtgagaga gagaagggga gaggaagaaa gagaggcaga gagtgtcaca     1200

gaaagatggc ttttccacat tagaacattt taatttaaga tatttaagaa caatatattt     1260

atgcccttat ttctttagag agaaaatacc ttaagtcagg taacactgag tttgtgggac     1320

cttaataaaa ttggcatact cttcataatg gtacctatct ggaatagtaa aaaatgagaa     1380

ccaccctgtg ttcatcttat gacatatgtg aaacttctaa tctattatca aatggactaa     1440

ttatcatgtt ctctatgtta gacaagtatc tagatgattt acacccttta gtgattattt     1500

tgtcaactat acaactacag ttactaactg tgatcaggat tttaattaaa atataattgc     1560

taagagtaaa aaaaaaaaaa                                                 1580


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys 
1               5                   10                  15  


<210>  6
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys Arg 
1               5                   10                  15      


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Gly Phe Gly Gly Val Leu Leu Tyr Ile Asp Pro Cys Asp Leu Pro 
1               5                   10                  15      


Lys 
    


<210>  8
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Glu Glu Met Asp Pro Ser Phe Asn Leu His Glu Thr Ile Thr Lys 
1               5                   10                  15      


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Gln Glu Glu Ser Asp Tyr Ile Thr His Tyr Thr Arg 
1               5                   10              


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Asn Asp Ile Leu Gln Asp Met Glu Lys 
1               5                   10      


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Asn Glu Ala Cys Ser Ser Leu Glu Leu Pro Asn Asn Glu Ile Arg 
1               5                   10                  15  


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Asn Ile Leu Tyr His Leu Asp Glu Lys 
1               5                   


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Asn Leu Val Gln Leu Tyr Lys 
1               5           


<210>  14
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Asn Leu Thr Ser Leu Leu Val Gln Pro Ile Ser Ala Pro Leu Val 
1               5                   10                  15      


Ala Lys 
        


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  15

Thr Ile Gln Ala Glu Asp Ile Lys 
1               5               


<210>  16
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr Lys Asn Glu Ala Cys Ser Ser Leu Glu Leu Pro Asn Asn Glu Ile 
1               5                   10                  15      


Arg 
    


<210>  17
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Leu Glu Gly Pro Ser Phe Leu Ser Glu Ala Arg 
1               5                   10          


<210>  18
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Val Ser Met Gln Val Gln Thr Val Thr Lys 
1               5                   10      


<210>  19
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Tyr Tyr Val His Thr Asn Cys Pro Ser Asp Ala Pro Ser Ser Gly 
1               5                   10                  15      


Thr Val Asp Pro Gln Leu Tyr Gln Glu Ile Leu Lys Thr Ile Gln Ala 
            20                  25                  30          


Glu Asp Ile Lys Lys Ser Phe Arg Asn Leu Val Gln Leu Tyr Lys Asn 
        35                  40                  45              


Glu Asp Asp Met Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser 
    50                  55                  60                  


Leu Gly Leu Glu Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp 
65                  70                  75                  80  


Leu Pro Gly Pro Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln 
                85                  90                  95      


Cys Phe His Pro Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp 
            100                 105                 110         


Ser Ser Gln Asp Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly 
        115                 120                 125             


Thr Leu Lys Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp 
    130                 135                 140                 


Leu Lys Arg Ile Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu 
145                 150                 155                 160 


Leu Lys Leu Gly Lys Leu Pro Leu Leu Tyr Lys Leu Ser Ser Leu Glu 
                165                 170                 175     


Lys Ala Gly Phe Gly Gly Val Leu Leu Tyr Ile Asp Pro Cys Asp Leu 
            180                 185                 190         


Pro Lys Thr Val Asn Pro Ser His Asp Thr Phe Met Val Ser Leu Asn 
        195                 200                 205             


Pro Gly Gly Asp Pro Ser Thr Pro Gly Tyr Pro Ser Val Asp Glu Ser 
    210                 215                 220                 


Phe Arg Gln Ser Arg Ser Asn Leu Thr Ser Leu Leu Val Gln Pro Ile 
225                 230                 235                 240 


Ser Ala Pro Leu Val Ala Lys Leu Ile Ser Ser Pro Lys Ala Arg Thr 
                245                 250                 255     


Lys Asn Glu Ala Cys Ser Ser Leu Glu Leu Pro Asn Asn Glu Ile Arg 
            260                 265                 270         


Val Val Ser Met Gln Val Gln Thr Val Thr Lys Leu Lys Thr Val Thr 
        275                 280                 285             


Asn Val Val Gly Phe Val Met Gly Leu Thr Ser Pro Asp Arg Tyr Ile 
    290                 295                 300                 


Ile Val Gly Ser His His His Thr Ala His Ser Tyr Asn Gly Gln Glu 
305                 310                 315                 320 


Trp Ala Ser Ser Thr Ala Ile Ile Thr Ala Phe Ile Arg Ala Leu Met 
                325                 330                 335     


Ser Lys Val Lys Arg Gly Trp Arg Pro Asp Arg Thr Ile Val Phe Cys 
            340                 345                 350         


Ser Trp Gly Gly Thr Ala Phe Gly Asn Ile Gly Ser Tyr Glu Trp Gly 
        355                 360                 365             


Glu Asp Phe Lys Lys Val Leu Gln Lys Asn Val Val Ala Tyr Ile Ser 
    370                 375                 380                 


Leu His Ser Pro Ile Arg Gly Asn Ser Ser Leu Tyr Pro Val Ala Ser 
385                 390                 395                 400 


Pro Ser Leu Gln Gln Leu Val Val Glu Lys Asn Asn Phe Asn Cys Thr 
                405                 410                 415     


Arg Arg Ala Gln Cys Pro Glu Thr Asn Ile Ser Ser Ile Gln Ile Gln 
            420                 425                 430         


Gly Asp Ala Asp Tyr Phe Ile Asn His Leu Gly Val Pro Ile Val Gln 
        435                 440                 445             


Phe Ala Tyr Glu Asp Ile Lys Thr Leu Glu Gly Pro Ser Phe Leu Ser 
    450                 455                 460                 


Glu Ala Arg Phe Ser Thr Arg Ala Thr Lys Ile Glu Glu Met Asp Pro 
465                 470                 475                 480 


Ser Phe Asn Leu His Glu Thr Ile Thr Lys Leu Ser Gly Glu Val Ile 
                485                 490                 495     


Leu Gln Ile Ala Asn Glu Pro Val Leu Pro Phe Asn Ala Leu Asp Ile 
            500                 505                 510         


Ala Leu Glu Val Gln Asn Asn Leu Lys Gly Asp Gln Pro Asn Thr His 
        515                 520                 525             


Gln Leu Leu Ala Met Ala Leu Arg Leu Arg Glu Ser Ala Glu Leu Phe 
    530                 535                 540                 


Gln Ser Asp Glu Met Arg Pro Ala Asn Asp Pro Lys Glu Arg Ala Pro 
545                 550                 555                 560 


Ile Arg Ile Arg Met Leu Asn Asp Ile Leu Gln Asp Met Glu Lys Ser 
                565                 570                 575     


Phe Leu Val Lys Gln Ala Pro Pro Gly Phe Tyr Arg Asn Ile Leu Tyr 
            580                 585                 590         


His Leu Asp Glu Lys Thr Ser Arg Phe Ser Ile Leu Ile Glu Ala Trp 
        595                 600                 605             


Glu His Cys Lys Pro Leu Ala Ser Asn Glu Thr Leu Gln Glu Ala Leu 
    610                 615                 620                 


Ser Glu Val Leu Asn Ser Ile Asn Ser Ala Gln Val Tyr Phe Lys Ala 
625                 630                 635                 640 


Gly Leu Asp Val Phe Lys Ser Val Leu Asp Gly Lys Asn 
                645                 650             


