                         SEQUENCE LISTING

<110>  INNATE PHARMA
 
<120>  TREATMENT OF PERIPHERAL T CELL LYMPHOMA

<130>  KIR-4

<150>  US 61/766,798
<151>  2013-02-20

<150>  US 61/831,809
<151>  2013-06-06

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  434
<212>  PRT
<213>  homo sapiens

<400>  1

Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Arg Pro Ser Thr 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Ala Leu Gln Cys His Tyr Arg Arg 
            20                  25                  30          


Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ser His Val Pro 
        35                  40                  45              


Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe Ile Met Gly Pro Val 
    50                  55                  60                  


Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg Gly Ser Arg Pro His 
65                  70                  75                  80  


Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro Leu Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Arg Asp Gly Ile Ser Glu Asp Pro Ser 
    130                 135                 140                 


Arg Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser Arg Glu Gly Glu Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Arg Ala Val Pro Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp Ser Asn Ser Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys Arg His Leu His Val 
305                 310                 315                 320 


Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe Ile Leu Leu Leu Phe 
                325                 330                 335     


Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met 
            340                 345                 350         


Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn Arg Gln Asp Ser Asp 
        355                 360                 365             


Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Val 
    370                 375                 380                 


Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln Arg Pro Lys Thr Pro 
385                 390                 395                 400 


Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro Asn Ala Glu Pro Arg 
                405                 410                 415     


Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln Ser Gly Leu Glu Gly 
            420                 425                 430         


Val Phe 
        


<210>  2
<211>  455
<212>  PRT
<213>  homo sapiens

<400>  2

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  3
<211>  123
<212>  PRT
<213>  mus musculus

<400>  3

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Phe 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Asn Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asn Ser Asn His Tyr Val Ser Ser Phe Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  4
<211>  106
<212>  PRT
<213>  mus musculus

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Thr Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  5
<211>  119
<212>  PRT
<213>  mus musculus

<400>  5

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Gly Asn Phe Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  6
<211>  112
<212>  PRT
<213>  mus musculus

<400>  6

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Phe Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Ser Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Thr Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  5
<212>  PRT
<213>  mus musculus

<400>  7

Asn Phe Gly Met Asn 
1               5   


<210>  8
<211>  6
<212>  PRT
<213>  mus musculus

<400>  8

Gly Tyr Thr Phe Thr Asn 
1               5       


<210>  9
<211>  10
<212>  PRT
<213>  mus musculus

<400>  9

Gly Tyr Thr Phe Thr Asn Phe Gly Met Asn 
1               5                   10  


<210>  10
<211>  15
<212>  PRT
<213>  mus musculus

<400>  10

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
1               5                   10                  15  


<210>  11
<211>  8
<212>  PRT
<213>  mus musculus

<400>  11

Trp Ile Asn Thr Tyr Thr Gly Glu 
1               5               


<210>  12
<211>  10
<212>  PRT
<213>  mus musculus

<400>  12

Asn Gly Asn Phe Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  13
<211>  16
<212>  PRT
<213>  mus musculus

<400>  13

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  14
<211>  7
<212>  PRT
<213>  mus musculus

<400>  14

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  mus musculus

<400>  15

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  16
<211>  112
<212>  PRT
<213>  mus musculus

<400>  16

Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met 
            20                  25                  30          


Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp 
        35                  40                  45              


Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly 
    50                  55                  60                  


Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln 
65                  70                  75                  80  


Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala His 
                85                  90                  95      


Gly Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


<210>  17
<211>  107
<212>  PRT
<213>  mus musculus

<400>  17

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Val Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ile Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Asp Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu 
            100                 105         


<210>  18
<211>  5
<212>  PRT
<213>  mus musculus

<400>  18

Asn Tyr Gly Met Asn 
1               5   


<210>  19
<211>  6
<212>  PRT
<213>  mus musculus

<400>  19

Gly Tyr Thr Phe Thr Asn 
1               5       


<210>  20
<211>  10
<212>  PRT
<213>  mus musculus

<400>  20

Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  21
<211>  17
<212>  PRT
<213>  mus musculus

<400>  21

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  10
<212>  PRT
<213>  mus musculus

<400>  22

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
1               5                   10  


<210>  23
<211>  6
<212>  PRT
<213>  mus musculus

<400>  23

Gly Pro Trp Leu Ala Tyr 
1               5       


<210>  24
<211>  11
<212>  PRT
<213>  mus musculus

<400>  24

Lys Ala Ser Gln Asp Ile Asn Val Tyr Leu Ser 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  mus musculus

<400>  25

Arg Ala Ile Arg Leu Val Asp 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  mus musculus

<400>  26

Leu Gln Tyr Asp Glu Leu Pro Tyr Thr 
1               5                   


<210>  27
<211>  455
<212>  PRT
<213>  homo sapiens

<400>  27

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  28
<211>  455
<212>  PRT
<213>  homo sapiens

<400>  28

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser His Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  29
<211>  428
<212>  PRT
<213>  homo sapiens

<400>  29

Lys Pro Phe Leu Ser Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly 
1               5                   10                  15      


His Val Ala Leu Gln Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met 
            20                  25                  30          


Leu Tyr Lys Glu Asp Arg Ser His Val Pro Ile Phe His Gly Arg Ile 
        35                  40                  45              


Phe Gln Glu Ser Phe Ile Met Gly Pro Val Thr Pro Ala His Ala Gly 
    50                  55                  60                  


Thr Tyr Arg Cys Arg Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser 
65                  70                  75                  80  


Thr Pro Ser Asn Pro Leu Val Ile Met Val Thr Gly Asn His Arg Lys 
                85                  90                  95      


Pro Ser Leu Leu Ala His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr 
            100                 105                 110         


Val Ile Leu Gln Cys Trp Ser Asp Val Met Phe Glu His Phe Phe Leu 
        115                 120                 125             


His Arg Glu Gly Ile Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile 
    130                 135                 140                 


His Asp Gly Val Ser Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro 
145                 150                 155                 160 


Val Leu Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro 
                165                 170                 175     


Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly 
            180                 185                 190         


Leu Tyr Glu Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln 
        195                 200                 205             


Ala Gly Glu Asn Val Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp 
    210                 215                 220                 


Ile Tyr His Leu Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg 
225                 230                 235                 240 


Ala Val Pro Lys Val Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly 
                245                 250                 255     


Pro Ala Thr His Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala 
            260                 265                 270         


Leu Pro Cys Val Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val 
        275                 280                 285             


Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser 
    290                 295                 300                 


Lys Ser Gly Ile Cys Arg His Leu His Val Leu Ile Gly Thr Ser Val 
305                 310                 315                 320 


Val Ile Phe Leu Phe Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp 
                325                 330                 335     


Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly 
            340                 345                 350         


Asp Arg Thr Val Asn Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu 
        355                 360                 365             


Val Met Tyr Ala Gln Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile 
    370                 375                 380                 


Ser Arg Pro Ser Gln Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val 
385                 390                 395                 400 


Tyr Thr Glu Leu Pro Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys 
                405                 410                 415     


Pro Arg Ala Pro Gln Ser Gly Leu Glu Gly Val Phe 
            420                 425             


<210>  30
<211>  455
<212>  PRT
<213>  homo sapiens

<400>  30

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Gln Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Thr Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Pro Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  31
<211>  455
<212>  PRT
<213>  homo sapiens

<400>  31

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe His Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  32
<211>  117
<212>  PRT
<213>  mus musculus

<400>  32

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Val Gln Lys Thr Pro Gly Lys Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Ser His Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Thr Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Glu Gly Val Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser 
        115         


<210>  33
<211>  107
<212>  PRT
<213>  mus musculus

<400>  33

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Ser Phe Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  34
<211>  6
<212>  PRT
<213>  mus musculus

<400>  34

Gly Tyr Thr Phe Thr Thr 
1               5       


<210>  35
<211>  5
<212>  PRT
<213>  mus musculus

<400>  35

Thr Ala Gly Met Gln 
1               5   


<210>  36
<211>  10
<212>  PRT
<213>  mus musculus

<400>  36

Gly Tyr Thr Phe Thr Thr Ala Gly Met Gln 
1               5                   10  


<210>  37
<211>  16
<212>  PRT
<213>  mus musculus

<400>  37

Trp Ile Asn Ser His Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe Lys 
1               5                   10                  15      


<210>  38
<211>  9
<212>  PRT
<213>  mus musculus

<400>  38

Trp Ile Asn Ser His Ser Gly Val Pro 
1               5                   


<210>  39
<211>  10
<212>  PRT
<213>  mus musculus

<400>  39

Gly Gly Asp Glu Gly Val Met Asp Tyr Trp 
1               5                   10  


<210>  40
<211>  11
<212>  PRT
<213>  mus musculus

<400>  40

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  41
<211>  7
<212>  PRT
<213>  mus musculus

<400>  41

Trp Thr Ser Thr Arg His Thr 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  mus musculus

<400>  42

Gln Gln His Tyr Ser Thr Pro Trp Thr 
1               5                   


