                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum
       Ruprecht-Karls-Universitt Heidelberg
 
<120>  The signature of Wnt/-catenin signaling in Cancer

<130>  DK10065EP

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  1413
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1413)

<400>  1
atg ggg aaa ctt cac tcc aag ccg gcc gcc gtg tgc aag cgc agg gag         48
Met Gly Lys Leu His Ser Lys Pro Ala Ala Val Cys Lys Arg Arg Glu           
1               5                   10                  15                

agc ccg gaa ggt gac agc ttc gcc gtg agc gct gcc tgg gct cgg aag         96
Ser Pro Glu Gly Asp Ser Phe Ala Val Ser Ala Ala Trp Ala Arg Lys           
            20                  25                  30                    

ggc atc gag gag tgg atc ggg aga cag cgc tgc ccg ggc ggt gtc tcg        144
Gly Ile Glu Glu Trp Ile Gly Arg Gln Arg Cys Pro Gly Gly Val Ser           
        35                  40                  45                        

gga ccc cga cag ctg cgg ttg gcg ggc acc ata ggc cga agc acc cgg        192
Gly Pro Arg Gln Leu Arg Leu Ala Gly Thr Ile Gly Arg Ser Thr Arg           
    50                  55                  60                            

gag ctc gtg ggc gac gtg ttg aga gac acg ctc agc gag gaa gag gag        240
Glu Leu Val Gly Asp Val Leu Arg Asp Thr Leu Ser Glu Glu Glu Glu           
65                  70                  75                  80            

gac gac ttt cgg ctg gaa gtg gcc ctg cct cct gag aag act gac ggg        288
Asp Asp Phe Arg Leu Glu Val Ala Leu Pro Pro Glu Lys Thr Asp Gly           
                85                  90                  95                

ctg ggc agc gga gat gag aag aag atg gag aga gtg agc gaa ccc tgc        336
Leu Gly Ser Gly Asp Glu Lys Lys Met Glu Arg Val Ser Glu Pro Cys           
            100                 105                 110                   

cca ggc tcc aag aag cag ctg aag ttt gaa gag ctc cag tgc gac gtg        384
Pro Gly Ser Lys Lys Gln Leu Lys Phe Glu Glu Leu Gln Cys Asp Val           
        115                 120                 125                       

tcc atg gag gag gac agc cgg cag gag tgg acc ttc acc ctg tat gac        432
Ser Met Glu Glu Asp Ser Arg Gln Glu Trp Thr Phe Thr Leu Tyr Asp           
    130                 135                 140                           

ttt gac aac aac ggc aag gtc acc cga gag gac atc acc agc ttg ctg        480
Phe Asp Asn Asn Gly Lys Val Thr Arg Glu Asp Ile Thr Ser Leu Leu           
145                 150                 155                 160           

cac acc atc tat gag gtg gtg gac tcc tct gtc aac cac tcc cca aca        528
His Thr Ile Tyr Glu Val Val Asp Ser Ser Val Asn His Ser Pro Thr           
                165                 170                 175               

tcc agc aag atg ctg cgg gta aag ctc acc gtg gcc ccc gat ggc agc        576
Ser Ser Lys Met Leu Arg Val Lys Leu Thr Val Ala Pro Asp Gly Ser           
            180                 185                 190                   

cag agc aag agg agc gtc ctt gtc aat cag gct gac ctg cag agc gca        624
Gln Ser Lys Arg Ser Val Leu Val Asn Gln Ala Asp Leu Gln Ser Ala           
        195                 200                 205                       

agg ccc cga gca gag acc aag ccc act gag gac ctg cgg agc tgg gag        672
Arg Pro Arg Ala Glu Thr Lys Pro Thr Glu Asp Leu Arg Ser Trp Glu           
    210                 215                 220                           

aag aag cag cga gcc ccg ctc agg ttc cag ggt gac agc cgc ctg gag        720
Lys Lys Gln Arg Ala Pro Leu Arg Phe Gln Gly Asp Ser Arg Leu Glu           
225                 230                 235                 240           

cag tct ggc tgc tac cac cat tgc gta gat gag aac atc gag agg aga        768
Gln Ser Gly Cys Tyr His His Cys Val Asp Glu Asn Ile Glu Arg Arg           
                245                 250                 255               

aac cac tac tta gat ctc gcc ggg ata gaa aac tac acg tcc caa ttt        816
Asn His Tyr Leu Asp Leu Ala Gly Ile Glu Asn Tyr Thr Ser Gln Phe           
            260                 265                 270                   

ggg cct ggc tcc cct tcc gtg gcc cag aag tca gaa ctg ccc ccc cgc        864
Gly Pro Gly Ser Pro Ser Val Ala Gln Lys Ser Glu Leu Pro Pro Arg           
        275                 280                 285                       

acc tcc aat ccc act cga tct cgc tcc cat gag ccg gaa gcc atc cac        912
Thr Ser Asn Pro Thr Arg Ser Arg Ser His Glu Pro Glu Ala Ile His           
    290                 295                 300                           

atc cca cac cga aag ccc caa ggc gtg gac ccg gcc tcc ttc cac ttc        960
Ile Pro His Arg Lys Pro Gln Gly Val Asp Pro Ala Ser Phe His Phe           
305                 310                 315                 320           

ctt gac acc cca atc gcc aag gtc tca gag ctc cag caa cgg ctc cgg       1008
Leu Asp Thr Pro Ile Ala Lys Val Ser Glu Leu Gln Gln Arg Leu Arg           
                325                 330                 335               

ggc acc cag gac ggg agc aag cac ttt gtg agg tcc ccc aag gcc cag       1056
Gly Thr Gln Asp Gly Ser Lys His Phe Val Arg Ser Pro Lys Ala Gln           
            340                 345                 350                   

ggc aag agt gtg ggt gtg ggc cac gtg gcc aga ggg gca aga aac aag       1104
Gly Lys Ser Val Gly Val Gly His Val Ala Arg Gly Ala Arg Asn Lys           
        355                 360                 365                       

ccc cct ctg gga ccc gcc atc cct gcg gtg tcc ccc tcc gcc cac ctg       1152
Pro Pro Leu Gly Pro Ala Ile Pro Ala Val Ser Pro Ser Ala His Leu           
    370                 375                 380                           

gct gcc agc ccg gcc ctc ctc ccc tcc cta gcc ccc ctc ggg cac aag       1200
Ala Ala Ser Pro Ala Leu Leu Pro Ser Leu Ala Pro Leu Gly His Lys           
385                 390                 395                 400           

aag cac aag cac cga gcc aag gag agc cag cag ggc tgc cgg ggc ctg       1248
Lys His Lys His Arg Ala Lys Glu Ser Gln Gln Gly Cys Arg Gly Leu           
                405                 410                 415               

cag gca cca ctg gcc tca ggt ggc cct gtc ctg ggg cgg gag cac ctg       1296
Gln Ala Pro Leu Ala Ser Gly Gly Pro Val Leu Gly Arg Glu His Leu           
            420                 425                 430                   

cgg gag ctg ccc gcc ttg gtg gtg tat gag agc cag gcc ggg cag ccg       1344
Arg Glu Leu Pro Ala Leu Val Val Tyr Glu Ser Gln Ala Gly Gln Pro           
        435                 440                 445                       

gtc cag aga cat gag cac cac cac cac cat gaa cat cac cac cat tac       1392
Val Gln Arg His Glu His His His His His Glu His His His His Tyr           
    450                 455                 460                           

cac cac ttc tac cag aca tag                                           1413
His His Phe Tyr Gln Thr                                                   
465                 470                                                   


<210>  2
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Lys Leu His Ser Lys Pro Ala Ala Val Cys Lys Arg Arg Glu 
1               5                   10                  15      


Ser Pro Glu Gly Asp Ser Phe Ala Val Ser Ala Ala Trp Ala Arg Lys 
            20                  25                  30          


Gly Ile Glu Glu Trp Ile Gly Arg Gln Arg Cys Pro Gly Gly Val Ser 
        35                  40                  45              


Gly Pro Arg Gln Leu Arg Leu Ala Gly Thr Ile Gly Arg Ser Thr Arg 
    50                  55                  60                  


Glu Leu Val Gly Asp Val Leu Arg Asp Thr Leu Ser Glu Glu Glu Glu 
65                  70                  75                  80  


Asp Asp Phe Arg Leu Glu Val Ala Leu Pro Pro Glu Lys Thr Asp Gly 
                85                  90                  95      


Leu Gly Ser Gly Asp Glu Lys Lys Met Glu Arg Val Ser Glu Pro Cys 
            100                 105                 110         


Pro Gly Ser Lys Lys Gln Leu Lys Phe Glu Glu Leu Gln Cys Asp Val 
        115                 120                 125             


Ser Met Glu Glu Asp Ser Arg Gln Glu Trp Thr Phe Thr Leu Tyr Asp 
    130                 135                 140                 


Phe Asp Asn Asn Gly Lys Val Thr Arg Glu Asp Ile Thr Ser Leu Leu 
145                 150                 155                 160 


His Thr Ile Tyr Glu Val Val Asp Ser Ser Val Asn His Ser Pro Thr 
                165                 170                 175     


Ser Ser Lys Met Leu Arg Val Lys Leu Thr Val Ala Pro Asp Gly Ser 
            180                 185                 190         


Gln Ser Lys Arg Ser Val Leu Val Asn Gln Ala Asp Leu Gln Ser Ala 
        195                 200                 205             


Arg Pro Arg Ala Glu Thr Lys Pro Thr Glu Asp Leu Arg Ser Trp Glu 
    210                 215                 220                 


Lys Lys Gln Arg Ala Pro Leu Arg Phe Gln Gly Asp Ser Arg Leu Glu 
225                 230                 235                 240 


Gln Ser Gly Cys Tyr His His Cys Val Asp Glu Asn Ile Glu Arg Arg 
                245                 250                 255     


Asn His Tyr Leu Asp Leu Ala Gly Ile Glu Asn Tyr Thr Ser Gln Phe 
            260                 265                 270         


Gly Pro Gly Ser Pro Ser Val Ala Gln Lys Ser Glu Leu Pro Pro Arg 
        275                 280                 285             


Thr Ser Asn Pro Thr Arg Ser Arg Ser His Glu Pro Glu Ala Ile His 
    290                 295                 300                 


Ile Pro His Arg Lys Pro Gln Gly Val Asp Pro Ala Ser Phe His Phe 
305                 310                 315                 320 


Leu Asp Thr Pro Ile Ala Lys Val Ser Glu Leu Gln Gln Arg Leu Arg 
                325                 330                 335     


Gly Thr Gln Asp Gly Ser Lys His Phe Val Arg Ser Pro Lys Ala Gln 
            340                 345                 350         


Gly Lys Ser Val Gly Val Gly His Val Ala Arg Gly Ala Arg Asn Lys 
        355                 360                 365             


Pro Pro Leu Gly Pro Ala Ile Pro Ala Val Ser Pro Ser Ala His Leu 
    370                 375                 380                 


Ala Ala Ser Pro Ala Leu Leu Pro Ser Leu Ala Pro Leu Gly His Lys 
385                 390                 395                 400 


Lys His Lys His Arg Ala Lys Glu Ser Gln Gln Gly Cys Arg Gly Leu 
                405                 410                 415     


Gln Ala Pro Leu Ala Ser Gly Gly Pro Val Leu Gly Arg Glu His Leu 
            420                 425                 430         


Arg Glu Leu Pro Ala Leu Val Val Tyr Glu Ser Gln Ala Gly Gln Pro 
        435                 440                 445             


Val Gln Arg His Glu His His His His His Glu His His His His Tyr 
    450                 455                 460                 


His His Phe Tyr Gln Thr 
465                 470 


<210>  3
<211>  936
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(936)

<400>  3
atg ggc gtc ccc acg gcc ctg gag gcc ggc agc tgg cgc tgg gga tcc         48
Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser           
1               5                   10                  15                

ctg ctc ttc gct ctc ttc ctg gct gcg tcc cta ggt ccg gtg gca gcc         96
Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala           
            20                  25                  30                    

ttc aag gtc gcc acg ccg tat tcc ctg tat gtc tgt ccc gag ggg cag        144
Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln           
        35                  40                  45                        

aac gtc acc ctc acc tgc agg ctc ttg ggc cct gtg gac aaa ggg cac        192
Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His           
    50                  55                  60                            

gat gtg acc ttc tac aag acg tgg tac cgc agc tcg agg ggc gag gtg        240
Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val           
65                  70                  75                  80            

cag acc tgc tca gag cgc cgg ccc atc cgc aac ctc acg ttc cag gac        288
Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp           
                85                  90                  95                

ctt cac ctg cac cat gga ggc cac cag gct gcc aac acc agc cac gac        336
Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp           
            100                 105                 110                   

ctg gct cag cgc cac ggg ctg gag tcg gcc tcc gac cac cat ggc aac        384
Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn           
        115                 120                 125                       

ttc tcc atc acc atg cgc aac ctg acc ctg ctg gat agc ggc ctc tac        432
Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr           
    130                 135                 140                           

tgc tgc ctg gtg gtg gag atc agg cac cac cac tcg gag cac agg gtc        480
Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val           
145                 150                 155                 160           

cat ggt gcc atg gag ctg cag gtg cag aca ggc aaa gat gca cca tcc        528
His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser           
                165                 170                 175               

aac tgt gtg gtg tac cca tcc tcc tcc cag gat agt gaa aac atc acg        576
Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr           
            180                 185                 190                   

gct gca gcc ctg gct acg ggt gcc tgc atc gta gga atc ctc tgc ctc        624
Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu           
        195                 200                 205                       

ccc ctc atc ctg ctc ctg gtc tac aag caa agg cag gca gcc tcc aac        672
Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn           
    210                 215                 220                           

cgc cgt gcc cag gag ctg gtg cgg atg gac agc aac att caa ggg att        720
Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile           
225                 230                 235                 240           

gaa aac ccc ggc ttt gaa gcc tca cca cct gcc cag ggg ata ccc gag        768
Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu           
                245                 250                 255               

gcc aaa gtc agg cac ccc ctg tcc tat gtg gcc cag cgg cag cct tct        816
Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser           
            260                 265                 270                   

gag tct ggg cgg cat ctg ctt tcg gag ccc agc acc ccc ctg tct cct        864
Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro           
        275                 280                 285                       

cca ggc ccc gga gac gtc ttc ttc cca tcc ctg gac cct gtc cct gac        912
Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp           
    290                 295                 300                           

tct cca aac ttt gag gtc atc tag                                        936
Ser Pro Asn Phe Glu Val Ile                                               
305                 310                                                   


<210>  4
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  5
<211>  345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(345)

<400>  5
atg gca ggc ttg gcc ctg cag cca ggc act gcc ctg ctg tgc tac tcc         48
Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser           
1               5                   10                  15                

tgc aaa gcc cag gtg agc aac gag gac tgc ctg cag gtg gag aac tgc         96
Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys           
            20                  25                  30                    

acc cag ctg ggg gag cag tgc tgg acc gcg cgc atc cgc gca gtt ggc        144
Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly           
        35                  40                  45                        

ctc ctg acc gtc atc agc aaa ggc tgc agc ttg aac tgc gtg gat gac        192
Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp           
    50                  55                  60                            

tca cag gac tac tac gtg ggc aag aag aac atc acg tgc tgt gac acc        240
Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr           
65                  70                  75                  80            

gac ttg tgc aac gcc agc ggg gcc cat gcc ctg cag ccg gct gct gcc        288
Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala           
                85                  90                  95                

atc ctt gcg ctg ctc cct gca ctc ggc ctg ctg ctc tgg gga ccc ggc        336
Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly           
            100                 105                 110                   

cag ctc tag                                                            345
Gln Leu                                                                   
                                                                          


<210>  6
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  7
<211>  1782
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1782)

<400>  7
atg gag cag cct gag gac atg gcg tcg ctg agc gag ttc gac tcc ttg         48
Met Glu Gln Pro Glu Asp Met Ala Ser Leu Ser Glu Phe Asp Ser Leu           
1               5                   10                  15                

gcg ggc agc atc ccg gcc acc aag gtg gag atc acc gtg tcc tgc agg         96
Ala Gly Ser Ile Pro Ala Thr Lys Val Glu Ile Thr Val Ser Cys Arg           
            20                  25                  30                    

aac ctc ctg gac aaa gac atg ttt tcc aag tcc gac cca ctg tgc gtc        144
Asn Leu Leu Asp Lys Asp Met Phe Ser Lys Ser Asp Pro Leu Cys Val           
        35                  40                  45                        

atg tat acc caa ggg atg gag aac aag cag tgg cgg gag ttt ggg cgc        192
Met Tyr Thr Gln Gly Met Glu Asn Lys Gln Trp Arg Glu Phe Gly Arg           
    50                  55                  60                            

acc gaa gtc atc gac aac acg ctc aat cct gac ttc gtg cgc aag ttc        240
Thr Glu Val Ile Asp Asn Thr Leu Asn Pro Asp Phe Val Arg Lys Phe           
65                  70                  75                  80            

att gtg gat tac ttt ttc gag gag aag cag aac ctc cgt ttt gat cta        288
Ile Val Asp Tyr Phe Phe Glu Glu Lys Gln Asn Leu Arg Phe Asp Leu           
                85                  90                  95                

tac gac gtt gac tct aag agt cct gat tta tcc aaa cac gat ttc ctg        336
Tyr Asp Val Asp Ser Lys Ser Pro Asp Leu Ser Lys His Asp Phe Leu           
            100                 105                 110                   

ggc cag gcc ttc tgc acc ctt gga gag att gtg ggg tcc cct ggg agc        384
Gly Gln Ala Phe Cys Thr Leu Gly Glu Ile Val Gly Ser Pro Gly Ser           
        115                 120                 125                       

cgc ctg gaa aag ccc ctc acg ata ggc gca ttc agc ctg aat tcc agg        432
Arg Leu Glu Lys Pro Leu Thr Ile Gly Ala Phe Ser Leu Asn Ser Arg           
    130                 135                 140                           

acg ggc aaa ccc atg cca gct gtg tcc aac ggt ggt gtc cca gga aag        480
Thr Gly Lys Pro Met Pro Ala Val Ser Asn Gly Gly Val Pro Gly Lys           
145                 150                 155                 160           

aaa tgt ggc acc atc atc ctg tcc gct gag gag ctc agc aac tgt agg        528
Lys Cys Gly Thr Ile Ile Leu Ser Ala Glu Glu Leu Ser Asn Cys Arg           
                165                 170                 175               

gat gtc gcc acc atg cag ttc tgt gcc aac aag ctg gac aag aaa gat        576
Asp Val Ala Thr Met Gln Phe Cys Ala Asn Lys Leu Asp Lys Lys Asp           
            180                 185                 190                   

ttc ttt ggg aaa tct gac ccc ttc ttg gta ttc tac aga agc aac gag        624
Phe Phe Gly Lys Ser Asp Pro Phe Leu Val Phe Tyr Arg Ser Asn Glu           
        195                 200                 205                       

gat gga acg ttc acc att tgc cac aag acc gag gtc atg aag aac acc        672
Asp Gly Thr Phe Thr Ile Cys His Lys Thr Glu Val Met Lys Asn Thr           
    210                 215                 220                           

cta aat cca gtc tgg caa act ttc tcc att ccc gtg aga gcc ctc tgc        720
Leu Asn Pro Val Trp Gln Thr Phe Ser Ile Pro Val Arg Ala Leu Cys           
225                 230                 235                 240           

aac ggc gac tac gat cgg acc atc aag gtg gag gtg tac gac tgg gat        768
Asn Gly Asp Tyr Asp Arg Thr Ile Lys Val Glu Val Tyr Asp Trp Asp           
                245                 250                 255               

cgg gac ggc agc cat gac ttc att ggg gag ttc acc acc agt tac cgg        816
Arg Asp Gly Ser His Asp Phe Ile Gly Glu Phe Thr Thr Ser Tyr Arg           
            260                 265                 270                   

gag ctg gcc cgt ggg cag agc caa ttc aac atc tat gag gtg gta aac        864
Glu Leu Ala Arg Gly Gln Ser Gln Phe Asn Ile Tyr Glu Val Val Asn           
        275                 280                 285                       

ccg aaa aag aaa atg aag aaa aag aaa tac gtg aat tct ggc aca gtc        912
Pro Lys Lys Lys Met Lys Lys Lys Lys Tyr Val Asn Ser Gly Thr Val           
    290                 295                 300                           

acc ctg ctt tcc ttt gct gtg gag tca gag tgc acc ttc ctt gac tac        960
Thr Leu Leu Ser Phe Ala Val Glu Ser Glu Cys Thr Phe Leu Asp Tyr           
305                 310                 315                 320           

atc aaa gga ggg acc cag atc aac ttc act gtg gcc att gat ttc act       1008
Ile Lys Gly Gly Thr Gln Ile Asn Phe Thr Val Ala Ile Asp Phe Thr           
                325                 330                 335               

gcc tcc aat ggg aac ccc tca cag tcc aca tcc ctg cac tac atg agc       1056
Ala Ser Asn Gly Asn Pro Ser Gln Ser Thr Ser Leu His Tyr Met Ser           
            340                 345                 350                   

ccc tac cag ctg aac gcc tac gcg ctg gcg ctg act gcc gtc gga gag       1104
Pro Tyr Gln Leu Asn Ala Tyr Ala Leu Ala Leu Thr Ala Val Gly Glu           
        355                 360                 365                       

atc atc cag cac tac gac agt gac aag atg ttc cct gcc ctg ggc ttc       1152
Ile Ile Gln His Tyr Asp Ser Asp Lys Met Phe Pro Ala Leu Gly Phe           
    370                 375                 380                           

ggg gcc aag ctg ccc ccg gat ggc aga gtg tcc cac gag ttc cca ctg       1200
Gly Ala Lys Leu Pro Pro Asp Gly Arg Val Ser His Glu Phe Pro Leu           
385                 390                 395                 400           

aat ggc aac cag gag aac ccc tca tgc tgt ggc atc gac ggc atc ctg       1248
Asn Gly Asn Gln Glu Asn Pro Ser Cys Cys Gly Ile Asp Gly Ile Leu           
                405                 410                 415               

gag gcc tac cac cgc agc ctg cgc act gtg cag ctg tac ggc ccc acc       1296
Glu Ala Tyr His Arg Ser Leu Arg Thr Val Gln Leu Tyr Gly Pro Thr           
            420                 425                 430                   

aac ttt gcc ccc gtg gtc acc cac gtg gcc agg aat gca gcg gcc gtg       1344
Asn Phe Ala Pro Val Val Thr His Val Ala Arg Asn Ala Ala Ala Val           
        435                 440                 445                       

cag gat ggc tcc cag tac tcg gtg ctg ctc atc att act gat ggg gtc       1392
Gln Asp Gly Ser Gln Tyr Ser Val Leu Leu Ile Ile Thr Asp Gly Val           
    450                 455                 460                           

atc tcg gac atg gcg cag acc aag gag gcc att gtc aac gct gcc aag       1440
Ile Ser Asp Met Ala Gln Thr Lys Glu Ala Ile Val Asn Ala Ala Lys           
465                 470                 475                 480           

ctc ccc atg tcc atc att atc gtc ggc gtg ggc cag gca gag ttc gac       1488
Leu Pro Met Ser Ile Ile Ile Val Gly Val Gly Gln Ala Glu Phe Asp           
                485                 490                 495               

gcc atg gtg gag ctg gat ggc gac gac gtg cgg atc tcc tcc cgg ggg       1536
Ala Met Val Glu Leu Asp Gly Asp Asp Val Arg Ile Ser Ser Arg Gly           
            500                 505                 510                   

aag ctg gct gaa cgc gac atc gtc cag ttt gta ccc ttc cgg gac tac       1584
Lys Leu Ala Glu Arg Asp Ile Val Gln Phe Val Pro Phe Arg Asp Tyr           
        515                 520                 525                       

gtg gac cgc aca ggc aac cac gtg ctg agc atg gcc cgc ctg gcc cga       1632
Val Asp Arg Thr Gly Asn His Val Leu Ser Met Ala Arg Leu Ala Arg           
    530                 535                 540                           

gac gtg ctg gca gag atc cct gac caa ctg gtg tcc tac atg aag gca       1680
Asp Val Leu Ala Glu Ile Pro Asp Gln Leu Val Ser Tyr Met Lys Ala           
545                 550                 555                 560           

cag ggc att cgc ccg cgt ccc cca ccc gca gca cca acc cac tcg ccc       1728
Gln Gly Ile Arg Pro Arg Pro Pro Pro Ala Ala Pro Thr His Ser Pro           
                565                 570                 575               

tcg cag tcc cca gcc cgc acg ccc cct gcg tcc ccc ctg cac acg cac       1776
Ser Gln Ser Pro Ala Arg Thr Pro Pro Ala Ser Pro Leu His Thr His           
            580                 585                 590                   

atc tga                                                               1782
Ile                                                                       
                                                                          


<210>  8
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Gln Pro Glu Asp Met Ala Ser Leu Ser Glu Phe Asp Ser Leu 
1               5                   10                  15      


Ala Gly Ser Ile Pro Ala Thr Lys Val Glu Ile Thr Val Ser Cys Arg 
            20                  25                  30          


Asn Leu Leu Asp Lys Asp Met Phe Ser Lys Ser Asp Pro Leu Cys Val 
        35                  40                  45              


Met Tyr Thr Gln Gly Met Glu Asn Lys Gln Trp Arg Glu Phe Gly Arg 
    50                  55                  60                  


Thr Glu Val Ile Asp Asn Thr Leu Asn Pro Asp Phe Val Arg Lys Phe 
65                  70                  75                  80  


Ile Val Asp Tyr Phe Phe Glu Glu Lys Gln Asn Leu Arg Phe Asp Leu 
                85                  90                  95      


Tyr Asp Val Asp Ser Lys Ser Pro Asp Leu Ser Lys His Asp Phe Leu 
            100                 105                 110         


Gly Gln Ala Phe Cys Thr Leu Gly Glu Ile Val Gly Ser Pro Gly Ser 
        115                 120                 125             


Arg Leu Glu Lys Pro Leu Thr Ile Gly Ala Phe Ser Leu Asn Ser Arg 
    130                 135                 140                 


Thr Gly Lys Pro Met Pro Ala Val Ser Asn Gly Gly Val Pro Gly Lys 
145                 150                 155                 160 


Lys Cys Gly Thr Ile Ile Leu Ser Ala Glu Glu Leu Ser Asn Cys Arg 
                165                 170                 175     


Asp Val Ala Thr Met Gln Phe Cys Ala Asn Lys Leu Asp Lys Lys Asp 
            180                 185                 190         


Phe Phe Gly Lys Ser Asp Pro Phe Leu Val Phe Tyr Arg Ser Asn Glu 
        195                 200                 205             


Asp Gly Thr Phe Thr Ile Cys His Lys Thr Glu Val Met Lys Asn Thr 
    210                 215                 220                 


Leu Asn Pro Val Trp Gln Thr Phe Ser Ile Pro Val Arg Ala Leu Cys 
225                 230                 235                 240 


Asn Gly Asp Tyr Asp Arg Thr Ile Lys Val Glu Val Tyr Asp Trp Asp 
                245                 250                 255     


Arg Asp Gly Ser His Asp Phe Ile Gly Glu Phe Thr Thr Ser Tyr Arg 
            260                 265                 270         


Glu Leu Ala Arg Gly Gln Ser Gln Phe Asn Ile Tyr Glu Val Val Asn 
        275                 280                 285             


Pro Lys Lys Lys Met Lys Lys Lys Lys Tyr Val Asn Ser Gly Thr Val 
    290                 295                 300                 


Thr Leu Leu Ser Phe Ala Val Glu Ser Glu Cys Thr Phe Leu Asp Tyr 
305                 310                 315                 320 


Ile Lys Gly Gly Thr Gln Ile Asn Phe Thr Val Ala Ile Asp Phe Thr 
                325                 330                 335     


Ala Ser Asn Gly Asn Pro Ser Gln Ser Thr Ser Leu His Tyr Met Ser 
            340                 345                 350         


Pro Tyr Gln Leu Asn Ala Tyr Ala Leu Ala Leu Thr Ala Val Gly Glu 
        355                 360                 365             


Ile Ile Gln His Tyr Asp Ser Asp Lys Met Phe Pro Ala Leu Gly Phe 
    370                 375                 380                 


Gly Ala Lys Leu Pro Pro Asp Gly Arg Val Ser His Glu Phe Pro Leu 
385                 390                 395                 400 


Asn Gly Asn Gln Glu Asn Pro Ser Cys Cys Gly Ile Asp Gly Ile Leu 
                405                 410                 415     


Glu Ala Tyr His Arg Ser Leu Arg Thr Val Gln Leu Tyr Gly Pro Thr 
            420                 425                 430         


Asn Phe Ala Pro Val Val Thr His Val Ala Arg Asn Ala Ala Ala Val 
        435                 440                 445             


Gln Asp Gly Ser Gln Tyr Ser Val Leu Leu Ile Ile Thr Asp Gly Val 
    450                 455                 460                 


Ile Ser Asp Met Ala Gln Thr Lys Glu Ala Ile Val Asn Ala Ala Lys 
465                 470                 475                 480 


Leu Pro Met Ser Ile Ile Ile Val Gly Val Gly Gln Ala Glu Phe Asp 
                485                 490                 495     


Ala Met Val Glu Leu Asp Gly Asp Asp Val Arg Ile Ser Ser Arg Gly 
            500                 505                 510         


Lys Leu Ala Glu Arg Asp Ile Val Gln Phe Val Pro Phe Arg Asp Tyr 
        515                 520                 525             


Val Asp Arg Thr Gly Asn His Val Leu Ser Met Ala Arg Leu Ala Arg 
    530                 535                 540                 


Asp Val Leu Ala Glu Ile Pro Asp Gln Leu Val Ser Tyr Met Lys Ala 
545                 550                 555                 560 


Gln Gly Ile Arg Pro Arg Pro Pro Pro Ala Ala Pro Thr His Ser Pro 
                565                 570                 575     


Ser Gln Ser Pro Ala Arg Thr Pro Pro Ala Ser Pro Leu His Thr His 
            580                 585                 590         


Ile 
    


<210>  9
<211>  1005
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1005)

<400>  9
atg gca gcg gcc gcc agc ccc gcg ttc ctt cta cgc ctc ccg ctt ctg         48
Met Ala Ala Ala Ala Ser Pro Ala Phe Leu Leu Arg Leu Pro Leu Leu           
1               5                   10                  15                

ctc ctg ctg tcc agc tgg tgc agg acc ggg ctg gcc gac cct cac tct         96
Leu Leu Leu Ser Ser Trp Cys Arg Thr Gly Leu Ala Asp Pro His Ser           
            20                  25                  30                    

ctt tgc tat gac atc acc gtc atc cct aag ttc aga cct gga cca cgg        144
Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg           
        35                  40                  45                        

tgg tgt gcg gtt caa ggc cag gtg gat gaa aag act ttt ctt cac tat        192
Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr           
    50                  55                  60                            

gac tgt ggc agc aag aca gtc aca ccc gtc agt ccc ctg ggg aag aaa        240
Asp Cys Gly Ser Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys           
65                  70                  75                  80            

cta aat gtc aca acg gcc tgg aaa gca cag aac cca gta ctg aga gag        288
Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu           
                85                  90                  95                

gtg gtg gac ata ctt aca gag caa ctg ctt gac att cag ctg gag aat        336
Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu Asn           
            100                 105                 110                   

tac ata ccc aag gaa ccc ctc acc ctg cag gcc agg atg tct tgt gag        384
Tyr Ile Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu           
        115                 120                 125                       

cag aaa gcc gaa gga cac ggc agt gga tct tgg cag ctc agt ttc gat        432
Gln Lys Ala Glu Gly His Gly Ser Gly Ser Trp Gln Leu Ser Phe Asp           
    130                 135                 140                           

gga cag atc ttc ctc ctc ttt gac tca gaa aac aga atg tgg aca acg        480
Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Asn Arg Met Trp Thr Thr           
145                 150                 155                 160           

gtt cat cct gga gcc aga aag atg aaa gaa aag tgg gag aat gac aag        528
Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys           
                165                 170                 175               

gat atg acc atg tcc ttc cat tac atc tca atg gga gac tgc aca gga        576
Asp Met Thr Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Thr Gly           
            180                 185                 190                   

tgg ctt gag gac ttc ttg atg ggc atg gac agc acc ctg gag cca agt        624
Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser           
        195                 200                 205                       

gca gga gca cca ccc acc atg tcc tca ggc aca gcc caa ccc agg gcc        672
Ala Gly Ala Pro Pro Thr Met Ser Ser Gly Thr Ala Gln Pro Arg Ala           
    210                 215                 220                           

acg gcc acc acc ctc atc ctt tgc tgc ctc ctc atc atg tgt ctc ctc        720
Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Met Cys Leu Leu           
225                 230                 235                 240           

ata tgc tcc agg cac agt ctg acc caa agc cat ggc cac cac cct cag        768
Ile Cys Ser Arg His Ser Leu Thr Gln Ser His Gly His His Pro Gln           
                245                 250                 255               

tcc ctg cag cct cct cct cat cct ccc ctg ctt cat cct acc tgg ctg        816
Ser Leu Gln Pro Pro Pro His Pro Pro Leu Leu His Pro Thr Trp Leu           
            260                 265                 270                   

ctg aga aga gtc ctt tgg agt gac agc tac caa ata gcg aag cgc ccc        864
Leu Arg Arg Val Leu Trp Ser Asp Ser Tyr Gln Ile Ala Lys Arg Pro           
        275                 280                 285                       

ttg tct ggt gga cac gtg act cgc gtg act tta cct atc att gga gac        912
Leu Ser Gly Gly His Val Thr Arg Val Thr Leu Pro Ile Ile Gly Asp           
    290                 295                 300                           

gac tca cac tcc tta ccc tgc cct ctt gcc ttg tat aca ata aat aac        960
Asp Ser His Ser Leu Pro Cys Pro Leu Ala Leu Tyr Thr Ile Asn Asn           
305                 310                 315                 320           

ggc gca gcc agg tat tcg gag cca cta cag gtc tcc ata tct tga           1005
Gly Ala Ala Arg Tyr Ser Glu Pro Leu Gln Val Ser Ile Ser                   
                325                 330                                   


<210>  10
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ala Ala Ala Ser Pro Ala Phe Leu Leu Arg Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Ser Trp Cys Arg Thr Gly Leu Ala Asp Pro His Ser 
            20                  25                  30          


Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg 
        35                  40                  45              


Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Gly Ser Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys 
65                  70                  75                  80  


Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu 
                85                  90                  95      


Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu Asn 
            100                 105                 110         


Tyr Ile Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


Gln Lys Ala Glu Gly His Gly Ser Gly Ser Trp Gln Leu Ser Phe Asp 
    130                 135                 140                 


Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Asn Arg Met Trp Thr Thr 
145                 150                 155                 160 


Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys 
                165                 170                 175     


Asp Met Thr Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Thr Gly 
            180                 185                 190         


Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser 
        195                 200                 205             


Ala Gly Ala Pro Pro Thr Met Ser Ser Gly Thr Ala Gln Pro Arg Ala 
    210                 215                 220                 


Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Met Cys Leu Leu 
225                 230                 235                 240 


Ile Cys Ser Arg His Ser Leu Thr Gln Ser His Gly His His Pro Gln 
                245                 250                 255     


Ser Leu Gln Pro Pro Pro His Pro Pro Leu Leu His Pro Thr Trp Leu 
            260                 265                 270         


Leu Arg Arg Val Leu Trp Ser Asp Ser Tyr Gln Ile Ala Lys Arg Pro 
        275                 280                 285             


Leu Ser Gly Gly His Val Thr Arg Val Thr Leu Pro Ile Ile Gly Asp 
    290                 295                 300                 


Asp Ser His Ser Leu Pro Cys Pro Leu Ala Leu Tyr Thr Ile Asn Asn 
305                 310                 315                 320 


Gly Ala Ala Arg Tyr Ser Glu Pro Leu Gln Val Ser Ile Ser 
                325                 330                 


<210>  11
<211>  939
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(939)

<400>  11
atg gtt gga ctg aag cct tca gac gtg cct ccc acc atg gct gtg aag         48
Met Val Gly Leu Lys Pro Ser Asp Val Pro Pro Thr Met Ala Val Lys           
1               5                   10                  15                

ttc ctg ggg gca ggc aca gca gcc tgt ttt gct gac ctc gtt acc ttt         96
Phe Leu Gly Ala Gly Thr Ala Ala Cys Phe Ala Asp Leu Val Thr Phe           
            20                  25                  30                    

cca ctg gac aca gcc aag gtc cgc ctg cag atc cag ggg gag aac cag        144
Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Ile Gln Gly Glu Asn Gln           
        35                  40                  45                        

gcg gtc cag acg gcc cgg ctc gtg cag tac cgt ggc gtg ctg ggc acc        192
Ala Val Gln Thr Ala Arg Leu Val Gln Tyr Arg Gly Val Leu Gly Thr           
    50                  55                  60                            

atc ctg acc atg gtg cgg act gag ggt ccc tgc agc ccc tac aat ggg        240
Ile Leu Thr Met Val Arg Thr Glu Gly Pro Cys Ser Pro Tyr Asn Gly           
65                  70                  75                  80            

ctg gtg gcc ggc ctg cag cgc cag atg agc ttc gcc tcc atc cgc atc        288
Leu Val Ala Gly Leu Gln Arg Gln Met Ser Phe Ala Ser Ile Arg Ile           
                85                  90                  95                

ggc ctc tat gac tcc gtc aag cag gtg tac acc ccc aaa ggc gcg gac        336
Gly Leu Tyr Asp Ser Val Lys Gln Val Tyr Thr Pro Lys Gly Ala Asp           
            100                 105                 110                   

aac tcc agc ctc act acc cgg att ttg gcc ggc tgc acc aca gga gcc        384
Asn Ser Ser Leu Thr Thr Arg Ile Leu Ala Gly Cys Thr Thr Gly Ala           
        115                 120                 125                       

atg gcg gtg acc tgt gcc cag ccc aca gat gtg gtg aag gtc cga ttt        432
Met Ala Val Thr Cys Ala Gln Pro Thr Asp Val Val Lys Val Arg Phe           
    130                 135                 140                           

cag gcc agc ata cac ctc ggg cca tcc agg agc gac aga aaa tac agc        480
Gln Ala Ser Ile His Leu Gly Pro Ser Arg Ser Asp Arg Lys Tyr Ser           
145                 150                 155                 160           

ggg act atg gac gcc tac aga acc atc gcc agg gag gaa gga gtc agg        528
Gly Thr Met Asp Ala Tyr Arg Thr Ile Ala Arg Glu Glu Gly Val Arg           
                165                 170                 175               

ggc ctg tgg aaa gga act ttg ccc aac atc atg agg aat gct atc gtc        576
Gly Leu Trp Lys Gly Thr Leu Pro Asn Ile Met Arg Asn Ala Ile Val           
            180                 185                 190                   

aac tgt gct gag gtg gtg acc tac gac atc ctc aag gag aag ctg ctg        624
Asn Cys Ala Glu Val Val Thr Tyr Asp Ile Leu Lys Glu Lys Leu Leu           
        195                 200                 205                       

gac tac cac ctg ctc act gac aac ttc ccc tgc cac ttt gtc tct gcc        672
Asp Tyr His Leu Leu Thr Asp Asn Phe Pro Cys His Phe Val Ser Ala           
    210                 215                 220                           

ttt gga gcc ggc ttc tgt gcc aca gtg gtg gcc tcc ccg gtg gac gtg        720
Phe Gly Ala Gly Phe Cys Ala Thr Val Val Ala Ser Pro Val Asp Val           
225                 230                 235                 240           

gtg aag acc cgg tat atg aac tca cct cca ggc cag tac ttc agc ccc        768
Val Lys Thr Arg Tyr Met Asn Ser Pro Pro Gly Gln Tyr Phe Ser Pro           
                245                 250                 255               

ctc gac tgt atg ata aag atg gtg gcc cag gag ggc ccc aca gcc ttc        816
Leu Asp Cys Met Ile Lys Met Val Ala Gln Glu Gly Pro Thr Ala Phe           
            260                 265                 270                   

tac aag gga ttt aca ccc tcc ttt ttg cgt ttg gga tcc tgg aac gtg        864
Tyr Lys Gly Phe Thr Pro Ser Phe Leu Arg Leu Gly Ser Trp Asn Val           
        275                 280                 285                       

gtg atg ttc gta acc tat gag cag ctg aaa cgg gcc ctg atg aaa gtc        912
Val Met Phe Val Thr Tyr Glu Gln Leu Lys Arg Ala Leu Met Lys Val           
    290                 295                 300                           

cag atg tta cgg gaa tca ccg ttt tga                                    939
Gln Met Leu Arg Glu Ser Pro Phe                                           
305                 310                                                   


<210>  12
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Gly Leu Lys Pro Ser Asp Val Pro Pro Thr Met Ala Val Lys 
1               5                   10                  15      


Phe Leu Gly Ala Gly Thr Ala Ala Cys Phe Ala Asp Leu Val Thr Phe 
            20                  25                  30          


Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Ile Gln Gly Glu Asn Gln 
        35                  40                  45              


Ala Val Gln Thr Ala Arg Leu Val Gln Tyr Arg Gly Val Leu Gly Thr 
    50                  55                  60                  


Ile Leu Thr Met Val Arg Thr Glu Gly Pro Cys Ser Pro Tyr Asn Gly 
65                  70                  75                  80  


Leu Val Ala Gly Leu Gln Arg Gln Met Ser Phe Ala Ser Ile Arg Ile 
                85                  90                  95      


Gly Leu Tyr Asp Ser Val Lys Gln Val Tyr Thr Pro Lys Gly Ala Asp 
            100                 105                 110         


Asn Ser Ser Leu Thr Thr Arg Ile Leu Ala Gly Cys Thr Thr Gly Ala 
        115                 120                 125             


Met Ala Val Thr Cys Ala Gln Pro Thr Asp Val Val Lys Val Arg Phe 
    130                 135                 140                 


Gln Ala Ser Ile His Leu Gly Pro Ser Arg Ser Asp Arg Lys Tyr Ser 
145                 150                 155                 160 


Gly Thr Met Asp Ala Tyr Arg Thr Ile Ala Arg Glu Glu Gly Val Arg 
                165                 170                 175     


Gly Leu Trp Lys Gly Thr Leu Pro Asn Ile Met Arg Asn Ala Ile Val 
            180                 185                 190         


Asn Cys Ala Glu Val Val Thr Tyr Asp Ile Leu Lys Glu Lys Leu Leu 
        195                 200                 205             


Asp Tyr His Leu Leu Thr Asp Asn Phe Pro Cys His Phe Val Ser Ala 
    210                 215                 220                 


Phe Gly Ala Gly Phe Cys Ala Thr Val Val Ala Ser Pro Val Asp Val 
225                 230                 235                 240 


Val Lys Thr Arg Tyr Met Asn Ser Pro Pro Gly Gln Tyr Phe Ser Pro 
                245                 250                 255     


Leu Asp Cys Met Ile Lys Met Val Ala Gln Glu Gly Pro Thr Ala Phe 
            260                 265                 270         


Tyr Lys Gly Phe Thr Pro Ser Phe Leu Arg Leu Gly Ser Trp Asn Val 
        275                 280                 285             


Val Met Phe Val Thr Tyr Glu Gln Leu Lys Arg Ala Leu Met Lys Val 
    290                 295                 300                 


Gln Met Leu Arg Glu Ser Pro Phe 
305                 310         


<210>  13
<211>  828
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(828)

<400>  13
atg gtt gga ctg aag cct tca gac gtg cct ccc acc atg gct gtg aag         48
Met Val Gly Leu Lys Pro Ser Asp Val Pro Pro Thr Met Ala Val Lys           
1               5                   10                  15                

ttc ctg ggg gca ggc aca gca gcc tgt ttt gct gac ctc gtt acc ttt         96
Phe Leu Gly Ala Gly Thr Ala Ala Cys Phe Ala Asp Leu Val Thr Phe           
            20                  25                  30                    

cca ctg gac aca gcc aag gtc cgc ctg cag atc cag ggg gag aac cag        144
Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Ile Gln Gly Glu Asn Gln           
        35                  40                  45                        

gcg gtc cag acg gcc cgg ctc gtg cag tac cgt ggc gtg ctg ggc acc        192
Ala Val Gln Thr Ala Arg Leu Val Gln Tyr Arg Gly Val Leu Gly Thr           
    50                  55                  60                            

atc ctg acc atg gtg cgg act gag ggt ccc tgc agc ccc tac aat ggg        240
Ile Leu Thr Met Val Arg Thr Glu Gly Pro Cys Ser Pro Tyr Asn Gly           
65                  70                  75                  80            

ctg gtg gcc ggc ctg cag cgc cag atg agc ttc gcc tcc atc cgc atc        288
Leu Val Ala Gly Leu Gln Arg Gln Met Ser Phe Ala Ser Ile Arg Ile           
                85                  90                  95                

ggc ctc tat gac tcc gtc aag cag gtg tac acc ccc aaa ggc gcg gac        336
Gly Leu Tyr Asp Ser Val Lys Gln Val Tyr Thr Pro Lys Gly Ala Asp           
            100                 105                 110                   

aac tcc agc ctc act acc cgg att ttg gcc ggc tgc acc aca gga gcc        384
Asn Ser Ser Leu Thr Thr Arg Ile Leu Ala Gly Cys Thr Thr Gly Ala           
        115                 120                 125                       

atg gcg gtg acc tgt gcc cag ccc aca gat gtg gtg aag gtc cga ttt        432
Met Ala Val Thr Cys Ala Gln Pro Thr Asp Val Val Lys Val Arg Phe           
    130                 135                 140                           

cag gcc agc ata cac ctc ggg cca tcc agg agc gac aga aaa tac agc        480
Gln Ala Ser Ile His Leu Gly Pro Ser Arg Ser Asp Arg Lys Tyr Ser           
145                 150                 155                 160           

ggg act atg gac gcc tac aga acc atc gcc agg gag gaa gga gtc agg        528
Gly Thr Met Asp Ala Tyr Arg Thr Ile Ala Arg Glu Glu Gly Val Arg           
                165                 170                 175               

ggc ctg tgg aaa gga act ttg ccc aac atc atg agg aat gct atc gtc        576
Gly Leu Trp Lys Gly Thr Leu Pro Asn Ile Met Arg Asn Ala Ile Val           
            180                 185                 190                   

aac tgt gct gag gtg gtg acc tac gac atc ctc aag gag aag ctg ctg        624
Asn Cys Ala Glu Val Val Thr Tyr Asp Ile Leu Lys Glu Lys Leu Leu           
        195                 200                 205                       

gac tac cac ctg ctc act gac aac ttc ccc tgc cac ttt gtc tct gcc        672
Asp Tyr His Leu Leu Thr Asp Asn Phe Pro Cys His Phe Val Ser Ala           
    210                 215                 220                           

ttt gga gcc ggc ttc tgt gcc aca gtg gtg gcc tcc ccg gtg gac gtg        720
Phe Gly Ala Gly Phe Cys Ala Thr Val Val Ala Ser Pro Val Asp Val           
225                 230                 235                 240           

gtg aag acc cgg tat atg aac tca cct cca ggc cag tac ttc agc ccc        768
Val Lys Thr Arg Tyr Met Asn Ser Pro Pro Gly Gln Tyr Phe Ser Pro           
                245                 250                 255               

ctc gac tgt atg ata aag atg gtg gcc cag gag ggc ccc aca gcc ttc        816
Leu Asp Cys Met Ile Lys Met Val Ala Gln Glu Gly Pro Thr Ala Phe           
            260                 265                 270                   

tac aag ggg tga                                                        828
Tyr Lys Gly                                                               
        275                                                               


<210>  14
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Gly Leu Lys Pro Ser Asp Val Pro Pro Thr Met Ala Val Lys 
1               5                   10                  15      


Phe Leu Gly Ala Gly Thr Ala Ala Cys Phe Ala Asp Leu Val Thr Phe 
            20                  25                  30          


Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Ile Gln Gly Glu Asn Gln 
        35                  40                  45              


Ala Val Gln Thr Ala Arg Leu Val Gln Tyr Arg Gly Val Leu Gly Thr 
    50                  55                  60                  


Ile Leu Thr Met Val Arg Thr Glu Gly Pro Cys Ser Pro Tyr Asn Gly 
65                  70                  75                  80  


Leu Val Ala Gly Leu Gln Arg Gln Met Ser Phe Ala Ser Ile Arg Ile 
                85                  90                  95      


Gly Leu Tyr Asp Ser Val Lys Gln Val Tyr Thr Pro Lys Gly Ala Asp 
            100                 105                 110         


Asn Ser Ser Leu Thr Thr Arg Ile Leu Ala Gly Cys Thr Thr Gly Ala 
        115                 120                 125             


Met Ala Val Thr Cys Ala Gln Pro Thr Asp Val Val Lys Val Arg Phe 
    130                 135                 140                 


Gln Ala Ser Ile His Leu Gly Pro Ser Arg Ser Asp Arg Lys Tyr Ser 
145                 150                 155                 160 


Gly Thr Met Asp Ala Tyr Arg Thr Ile Ala Arg Glu Glu Gly Val Arg 
                165                 170                 175     


Gly Leu Trp Lys Gly Thr Leu Pro Asn Ile Met Arg Asn Ala Ile Val 
            180                 185                 190         


Asn Cys Ala Glu Val Val Thr Tyr Asp Ile Leu Lys Glu Lys Leu Leu 
        195                 200                 205             


Asp Tyr His Leu Leu Thr Asp Asn Phe Pro Cys His Phe Val Ser Ala 
    210                 215                 220                 


Phe Gly Ala Gly Phe Cys Ala Thr Val Val Ala Ser Pro Val Asp Val 
225                 230                 235                 240 


Val Lys Thr Arg Tyr Met Asn Ser Pro Pro Gly Gln Tyr Phe Ser Pro 
                245                 250                 255     


Leu Asp Cys Met Ile Lys Met Val Ala Gln Glu Gly Pro Thr Ala Phe 
            260                 265                 270         


Tyr Lys Gly 
        275 


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UBC forward primer

<400>  15
ggcaaagatc caagataagg aa                                                22


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UBC reverse primer

<400>  16
ggaccaagtg cagagtggac                                                   20


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH forward primer

<400>  17
agccacatcg ctcagacac                                                    19


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH reverse primer

<400>  18
gcccaatacg accaaatcc                                                    19


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB forward primer

<400>  19
attggcaatg agcggttc                                                     18


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB reverse primer

<400>  20
tgaaggtagt ttcgtggatg c                                                 21


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M forward primer

<400>  21
ttctggcctg gaggctatc                                                    19


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M reverse primer

<400>  22
tcaggaaatt tgactttcca ttc                                               23


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  18s forward primer

<400>  23
ggagagggag cctgagaaac                                                   20


<210>  24
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  18s reverse primer

<400>  24
tcgggagtgg gtaatttgc                                                    19


