                         SEQUENCE LISTING

<110>  RSEM, Limited Partnership
       Sapieha, Przemyslaw
 
<120>  INHIBITION OF SEMA3A IN THE PREVENTION AND TREATMENT OF OCULAR 
       HYPERPERMEABILITY

<130>  12810_496

<140>  N/A
<141>  2014-02-21

<150>  US 61/767,419
<151>  2013-02-21

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  771
<212>  PRT
<213>  homosapiens

<400>  1

Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      


Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     


Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     


Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         


Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His Asp Asn His His 
                565                 570                 575     


Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser 
            580                 585                 590         


Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp 
        595                 600                 605             


Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp 
    610                 615                 620                 


Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln 
625                 630                 635                 640 


Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe 
                645                 650                 655     


Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His 
            660                 665                 670         


Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr 
        675                 680                 685             


Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg 
    690                 695                 700                 


Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu 
705                 710                 715                 720 


Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg 
                725                 730                 735     


Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu 
            740                 745                 750         


Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro 
        755                 760                 765             


Arg Ser Val 
    770     


<210>  2
<211>  609
<212>  PRT
<213>  homosapiens

<400>  2

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Gly Thr Thr Val Leu 
            580                 585                 590         


Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ile 
        595                 600                 605             


Lys 
    


<210>  3
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  3
aaatccttga tattaaccag g                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  4
tttcccgtaa atatcacacc g                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  5
ttgaaactac tttaagaacg g                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  6
aaattagcac attctttcag g                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  7
aaattgccaa tataccaagg c                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  8
aatgagctgc atgaagtctc g                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  9
aaattggcac attctttcag g                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  10
ttcattagga atacatcctg c                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  11
ttatttatag gaaacactgg g                                                 21


<210>  12
<211>  923
<212>  PRT
<213>  human

<400>  12

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  13
<211>  280
<212>  PRT
<213>  human

<400>  13

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly 
        275                 280 


<210>  14
<211>  923
<212>  PRT
<213>  mus musculus

<400>  14

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Thr Leu Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Val Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Lys Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Ser Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Leu Gly Val Phe Ser Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Val Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Ala Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Thr Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Thr 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Ser Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Pro Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Ile Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Ser His Ala Gln Leu Arg 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Ser Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Val Val Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Thr Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Thr Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Pro Gln Ser Asn Tyr Ser Glu Ala 
        915                 920             


<210>  15
<211>  922
<212>  PRT
<213>  rattus norvegicus

<400>  15

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Thr Leu Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Phe Arg Ser Asp Lys Cys Gly Gly Thr Ile Lys 
            20                  25                  30          


Ile Glu Asn Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Glu Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Ile Asp Gly Glu Asn Glu Gly 
                85                  90                  95      


Gly Arg Leu Trp Gly Lys Phe Cys Gly Lys Ile Ala Pro Ser Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Ala Pro Thr Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Ile Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Gln Asp Ser Asn Pro Pro Gly Gly Val Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Glu Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Ile Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Gly Thr Asn Trp Ser Val Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Arg Val Asp Ile Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Leu Lys Glu Gly Asn Lys Ala Ile Ile Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Phe Gly Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Ser Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ala Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Thr Gly Trp Ala Leu Pro Pro Ser Pro His Pro Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Val Asp Leu Gly Asp Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Val Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Ala Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Ala Phe Thr Pro Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Ser Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Val Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Pro Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Ile Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Ser His Ala Gln Leu Arg 
            660                 665                 670         


Trp Arg Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Ser Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu His Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Val Val Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Pro Gln Glu Asp Cys Ala Lys Pro Thr Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Thr Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Glu Gly Lys Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn 
        835                 840                 845             


Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser 
    850                 855                 860                 


Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr Cys 
865                 870                 875                 880 


Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu Glu 
                885                 890                 895     


Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp Lys 
            900                 905                 910         


Leu Asn Pro Gln Ser Asn Tyr Ser Glu Ala 
        915                 920         


